CN112957447A - Traditional Chinese medicine composition for treating adenomyosis and preparation method and application of Chinese herbal medicine superfine powder capsule preparation - Google Patents

Traditional Chinese medicine composition for treating adenomyosis and preparation method and application of Chinese herbal medicine superfine powder capsule preparation Download PDF

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CN112957447A
CN112957447A CN202110405709.XA CN202110405709A CN112957447A CN 112957447 A CN112957447 A CN 112957447A CN 202110405709 A CN202110405709 A CN 202110405709A CN 112957447 A CN112957447 A CN 112957447A
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traditional chinese
chinese medicine
medicine composition
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肖雁冰
任晓燕
席雯
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Abstract

The invention belongs to the technical field of traditional Chinese medicine pharmacy, and particularly relates to a traditional Chinese medicine composition for treating adenomyosis, and a preparation method and application of a Chinese herbal medicine superfine powder capsule preparation. The traditional Chinese medicine composition provided by the invention comprises astragalus mongholicus, codonopsis pilosula, Chinese yam, caulis spatholobi, salvia miltiorrhiza, angelica sinensis, scorpio, ground beeltle, rhizoma sparganii, curcuma zedoary, houttuynia cordata, patrinia, rhizoma smilacis glabrae, semen euryales, radix sophorae flavescentis, bighead atractylodes rhizome, rhizoma corydalis, fructus toosendan, baked ginger and cinnamon. The traditional Chinese medicine composition disclosed by the invention has the effects of tonifying qi and activating blood, reducing phlegm and removing blood stasis, warming channels and dispelling cold, clearing damp and heat, and eliminating dryness and stopping leukorrhagia, has a good clinical effect on patients with adenomyosis, can effectively improve the leukorrhagia condition, is low in cost, good in curative effect, time-saving and labor-saving, convenient to use, free of toxic and side effects, free of addition and subtraction according to symptoms, remarkable in economic and social benefits, and worthy of further popularization clinically.

Description

Traditional Chinese medicine composition for treating adenomyosis and preparation method and application of Chinese herbal medicine superfine powder capsule preparation
Technical Field
The invention belongs to the technical field of traditional Chinese medicine pharmacy, and particularly relates to a traditional Chinese medicine composition for treating adenomyosis, and a preparation method and application of a Chinese herbal medicine superfine powder capsule preparation for treating adenomyosis.
Background
Adenomyosis (adenomyyosis) refers to the fact that endometrial glands and interstitium exist in an myometrium, and the incidence rate of adenomyosis (adenomyomyosis) is 10% -47% of women with compensatory hypertrophy and hyperplasia of cells of peripheral muscularis (women's obstetrics (8 th edition), Xiuyang, Lexu Wen Shu, people's health publisher, 2013: 275). Its main clinical manifestations include increased menstruation volume, prolonged menstrual period, and gradually aggravated dysmenorrhea and infertility. Adenomyosis is a common and frequently encountered gynecological disease, seriously affects physical and mental health and life quality of patients, and is concerned by the industry. Patients with adenomyosis almost all have symptoms such as increased menstruation volume, menostaxis, dysmenorrheal and the like, and the current treatment modes can be divided into two types: one is to retain the conservative treatment of the uterus, including drug treatment, physical treatment and conservative operative treatment (focal resection); the second is the treatment of unreserved uterus, i.e. hysterectomy.
The medicines for treating adenomyosis are various, such as mifepristone, danazol, gestrinone, GnRH-a, dydrogesterone, dienogest and the like, and the treatment has the problems of large curative effect difference, obvious side effect, high cost, relapse after stopping medicine and the like (Yang J-H, Ho H-N, Yang Y-S.Current diagnostic and treatment strategies for adenomyosis, expert Rev.Obstet.Gynecol,2006,1(1): 111-. The physical therapy mainly comprises High Intensity Focused Ultrasound (HIFU), but has the problems of expensive equipment, non-universal applicability, incomplete treatment, easy recurrence and the like (Dong X, Yang Z.high-intensity focused ultrasound association of the problem of the expensive equipment, non-universal applicability, incomplete treatment, easy recurrence and the like (Current Optin Gynecol 2010,22: 326; Min Zhou, Jin-Yun Chen, Liang-Dan Tang, Wen-Zhi Chen, Zhi-Biao wave. ultrasonic-output-identified High-intensity focused ultrasound association for the problem of the present clinical experience of the patient, 35900). Conservative operations include Uterine artery interventional embolization (UAE), hysteroscopic endometrial ablation (TCRE), and Uterine focal ablation (RUL). These conservative treatment regimens all have the problems of a small range of indications, incomplete treatment, susceptibility to recurrence, etc. (Gupta, J.K, Sinha, A., Lumsden, et al. A. department of labor acute infection for systemic material filtration. Cochrane Database of Systematic reviews.2006, (1) CD 005073; Valhsht A, study JW, Carcardiac 32 "fibrous infection: A technical Not great Signal compatibility". British Journal of Obstecs & Gynecology.2000,107(9): 1166-1170; WaCJ, Yen CF, Lele CL, et al. Laroscosystem research tissue evaluation, 296; clinical application of biomedical devices, 300. J. application of Yu et al., Lanchonghuan et al., Japan and Yu et al. 300. Yu Hua et al. application of Yu Hua et al., Japan, 300. Biotechnology and Yu Yang et al. Biotechnology of labor acute research & gt, AH.. 356-1170. WacFangyuan, WacCF, Lene CL, and Yu et al. Lang. Massach et al. application of Yu et al. No. 300. Yu et al. Through long-term exploration and practice, the applicant invents three schemes of 'Manyule (IUS)' based on 'indexing thought' and 'Shore agate technology (MUFU)' for treating medium and severe adenomyosis and other treatment method losers (Xiaoyan Bing, Zhao Jing, Li Qinghan, and the like, 'major muscular wall resection-uterine reconstruction' for treating medium and severe adenomyosis-operative and safety discussion, follow the academy of medicine, 2012,35(4):302- "305), and obtains good effects. However, the ingredient of manyuele (IUS) is levonorgestrel, absolute and related contraindications exist in clinical application, and the manyuele (IUS) is not suitable for all patients and is expensive; MURU, although effective, is a traumatic treatment and usually requires a method to prevent postoperative recurrence.
In the field of traditional Chinese medicine, adenomyosis of diseases such as dysmenorrheal, menorrhagia, menostaxis and infertility; it is considered that the onset of this disease is related to the internal resistance of blood stasis, while the formation of clinical symptoms is related to the pathogenic factors such as congealing cold, qi stagnation and phlegm-dampness. In the aspect of treatment, blood circulation is mainly promoted and blood stasis is mainly removed, and the mutual consideration is given to the reasons of blood stasis formation and the degree of weakness, so that the body resistance is strengthened and pathogenic factors are eliminated, and the syndrome differentiation is as follows: the four symptoms of qi stagnation and blood stasis, phlegm coagulation and blood stasis, cold coagulation and blood stasis and qi and blood deficiency are treated according to the four symptoms. The curative effect varies from person to person, and the curative effect is greatly changed, and the individual principle is followed, and the special patent medicine is lacked, so that the application of the medicine in clinic is limited, so that no special Chinese patent medicine for treating adenomyosis exists so far, and the application of the traditional Chinese medicine in adenomyosis is greatly hindered.
Disclosure of Invention
In view of the above, the present invention aims to provide a traditional Chinese medicine composition for treating adenomyosis, a preparation method of a Chinese herbal medicine superfine powder capsule preparation for treating adenomyosis, and applications of the Chinese herbal medicine superfine powder capsule preparation. The traditional Chinese medicine composition provided by the invention is safe in components and reasonable in formula, and the production cost is reduced; convenient use and no toxic or side effect; does not need syndrome differentiation treatment and addition and subtraction according to symptoms, and has universality; can effectively improve the leucorrhea condition, has good treatment effect on the patient with the uterine gland myopathy, and has no recurrence phenomenon.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a traditional Chinese medicine composition for treating adenomyosis, which comprises the following components in parts by mass: 5-15 parts of astragalus membranaceus, 1-8 parts of codonopsis pilosula, 2-8 parts of Chinese yam, 5-15 parts of caulis spatholobi, 5-15 parts of salvia miltiorrhiza, 2-8 parts of angelica sinensis, 1-7 parts of scorpio, 1-7 parts of ground beeltle, 2-5 parts of rhizoma sparganii, 2-5 parts of curcuma zedoary, 5-15 parts of houttuynia cordata, 5-15 parts of patrinia scabiosaefolia, 2-10 parts of rhizoma smilacis glabrae, 2-8 parts of gorgon fruit, 2-8 parts of radix sophorae flavescentis, 2-5 parts of bighead atractylodes rhizome, 2-8 parts of rhizoma corydalis, 2-5 parts of szechwan chinaberry fruit.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by mass: 10 parts of astragalus, 3 parts of codonopsis pilosula, 3 parts of Chinese yam, 10 parts of caulis spatholobi, 10 parts of salvia miltiorrhiza, 3 parts of angelica, 2 parts of scorpion, 2 parts of ground beeltle, 3 parts of rhizoma sparganii, 3 parts of curcuma zedoary, 10 parts of houttuynia cordata, 10 parts of herba patriniae, 4 parts of rhizoma smilacis glabrae, 3 parts of gordon euryale seed, 3 parts of radix sophorae flavescentis, 3 parts of bighead atractylodes rhizome, 3 parts of rhizoma corydalis, 3 parts of szechwan chinaberry fruit, 2 parts.
Preferably, the dosage form of the traditional Chinese medicine composition comprises Chinese herbal medicine superfine powder capsule preparations, granules, tablets, powder and decoction.
The invention also provides a preparation method of the Chinese medicinal composition Chinese herbal medicine superfine powder capsule preparation, which comprises the following steps:
providing powder of the components in the traditional Chinese medicine composition;
carrying out superfine grinding on the powder to obtain superfine powder;
and (3) encapsulating the superfine powder to obtain the Chinese herbal medicine superfine powder capsule preparation.
Preferably, the capsule is filled into capsules according to 0.1g to 0.5g per capsule.
Preferably, the particle size of the superfine powder is less than or equal to 10 mu m.
The invention also provides application of the traditional Chinese medicine composition or the preparation prepared by the preparation method in preparing a medicine for treating adenomyosis.
The invention provides a traditional Chinese medicine composition for treating adenomyosis, which comprises astragalus, codonopsis pilosula, Chinese yam, caulis spatholobi, salvia miltiorrhiza, angelica, scorpion, ground beeltle, rhizoma sparganii, curcuma zedoary, houttuynia cordata, patrinia, rhizoma smilacis glabrae, semen euryales, sophora flavescens, bighead atractylodes rhizome, rhizoma corydalis, szechwan chinaberry fruit, baked ginger and cinnamon. In the traditional Chinese medicine composition provided by the invention, the astragalus, the codonopsis pilosula and the Chinese yam inhibit the activity of platelet calmodulin and phosphodiesterase, so that the cAMP content in platelets is increased, the platelet aggregation resisting effect can be effectively exerted, the organism immune function is improved, the organism cellular immune response capability is enhanced, the constitution is strengthened by strengthening the body resistance, and the astragalus, the codonopsis pilosula and the Chinese yam are used as monarch drugs together; the caulis spatholobi, the salvia miltiorrhiza and the angelica sinensis inhibit platelet aggregation induced by ADP and collagen, prolong the time of blood viscosity and prothrombin, play an anti-inflammatory role, accelerate tissue repair, nourish blood and activate blood circulation, and are used as ministerial drugs; scorpio, Eupolyphaga Seu Steleophaga, rhizoma Sparganii and Curcumae rhizoma can enhance the immunity principle of tumor cells, induce or promote immunological rejection reaction of organism to tumor, inhibit the growth of CA cell, make Cervix CA tissue necrosis, drop, break blood and remove blood stasis, soften hard masses and eliminate abdominal mass, and be used as adjuvant drugs; herba houttuyniae, herba patriniae, rhizoma smilacis glabrae, semen euryales, radix sophorae flavescentis and rhizoma atractylodis macrocephalae are used as guiding drugs for inhibiting formaldehyde foot swelling of experimental animals, inhibiting serous fluid exudation, promoting tissue regeneration and wound healing, and having the effects of clearing away damp-heat, stopping leukorrhagia, eliminating dampness, dissolving turbidity and relieving pain; and adding cinnamon and baked ginger for warming channel and dispelling cold, and corydalis tuber and szechwan chinaberry fruit for flowing liver and regulating qi, regulating qi activity and harmonizing the medicaments for jointly playing the functions of promoting blood circulation and removing blood stasis. The traditional Chinese medicine composition provided by the invention has safe components, scientific and reasonable compatibility and no toxic or side effect; the traditional Chinese medicine composition does not need to be treated according to syndrome differentiation and added or reduced according to symptoms, and is generally applicable; can effectively improve the leucorrhea condition, has good treatment effect on the patient with the uterine gland myopathy, does not relapse, and improves the life quality of the patient.
Meanwhile, the Chinese herbal medicine ultrafine powder capsule preparation has the advantages of simple preparation method, convenient use, low cost and contribution to reducing the dosage, is an innovation for treating adenomyosis by traditional Chinese medicines, and has remarkable economic and social benefits. The embodiment shows that the traditional Chinese medicine composition provided by the invention has the advantages of good curative effect on the adenomyosis, time and labor saving and no relapse.
Detailed Description
The invention provides a traditional Chinese medicine composition for treating adenomyosis, which comprises the following components in parts by mass: 5-15 parts of astragalus membranaceus, 1-8 parts of codonopsis pilosula, 2-8 parts of Chinese yam, 5-15 parts of caulis spatholobi, 5-15 parts of salvia miltiorrhiza, 2-8 parts of angelica sinensis, 1-7 parts of scorpio, 1-7 parts of ground beeltle, 2-5 parts of rhizoma sparganii, 2-5 parts of curcuma zedoary, 5-15 parts of houttuynia cordata, 5-15 parts of patrinia scabiosaefolia, 2-10 parts of rhizoma smilacis glabrae, 2-8 parts of gorgon fruit, 2-8 parts of radix sophorae flavescentis, 2-5 parts of bighead atractylodes rhizome, 2-8 parts of rhizoma corydalis, 2-5 parts of szechwan chinaberry fruit.
The traditional Chinese medicine composition for treating adenomyosis comprises, by mass, 5-15 parts of astragalus membranaceus, preferably 8-12 parts of astragalus membranaceus, and further preferably 10 parts of astragalus membranaceus.
Based on the mass parts of the astragalus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 1-8 parts of codonopsis pilosula, preferably 2-5 parts of codonopsis pilosula, and further preferably 3 parts of codonopsis pilosula.
Based on the mass parts of the astragalus membranaceus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 2-8 parts of Chinese yam, and preferably 3 parts of Chinese yam.
In the invention, the astragalus, the codonopsis pilosula and the Chinese yam are used as monarch drugs, and the healthy energy is strengthened.
Based on the mass parts of the astragalus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 5-15 parts of caulis spatholobi, preferably 8-12 parts of caulis spatholobi, and more preferably 10 parts of caulis spatholobi.
The traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 5-15 parts of salvia miltiorrhiza, preferably 8-12 parts of radix astragali, and more preferably 10 parts of radix astragali by mass.
Based on the mass parts of the astragalus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 2-8 parts of angelica, preferably 3 parts.
In the invention, the caulis spatholobi, the salvia miltiorrhiza bunge and the angelica sinensis are used as ministerial drugs for nourishing blood and activating blood.
Based on the mass parts of the astragalus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 1-7 parts of scorpion, preferably 2-5 parts, and further preferably 2 parts.
Based on the mass parts of the astragalus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 1-7 parts of ground beetle, and preferably 2 parts of ground beetle.
The traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 2-5 parts of rhizoma sparganii, preferably 2-5 parts of radix astragali, and more preferably 2 parts of radix astragali.
Based on the mass parts of the astragalus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 2-10 parts of curcuma zedoary, preferably 3-7 parts of curcuma zedoary, and further preferably 3 parts of curcuma zedoary.
In the invention, the scorpion, the ground beeltle, the rhizoma sparganii and the curcuma zedoary are used as adjuvant drugs for breaking blood and dispelling stasis, softening hardness and eliminating mass.
The traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 5-15 parts of houttuynia cordata, preferably 8-12 parts of houttuynia cordata, and further preferably 10 parts of astragalus membranaceus by mass.
Based on the mass parts of the astragalus membranaceus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 5-15 parts of patrinia, preferably 8-12 parts of patrinia, and more preferably 10 parts of patrinia.
Based on the mass parts of the astragalus membranaceus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 2-10 parts of rhizoma smilacis glabrae, preferably 3-7 parts of rhizoma smilacis glabrae, and further preferably 4 parts of rhizoma smilacis glabrae.
Based on the mass parts of the astragalus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 2-8 parts of gordon euryale seeds, and preferably 3 parts.
Based on the mass parts of the astragalus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 2-8 parts of radix sophorae flavescentis, and preferably 3 parts of radix sophorae flavescentis.
Based on the mass parts of the astragalus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 2-5 parts of bighead atractylodes rhizome, and preferably 3 parts.
In the invention, the cordate houttuynia, the patrinia, the glabrous greenbrier rhizome, the gordon euryale seed, the lightyellow sophora root and the bighead atractylodes rhizome are used as guiding drugs, and have the effects of clearing away damp-heat, stopping leukorrhagia, eliminating dampness, eliminating turbid pathogen and relieving pain.
Based on the mass parts of the astragalus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 2-8 parts of corydalis tuber, and preferably 3 parts of corydalis tuber.
Based on the mass parts of the astragalus membranaceus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 2-5 parts of szechwan chinaberry fruit, and preferably 3 parts.
Based on the mass parts of the astragalus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 1-3 parts of baked ginger, and preferably 2 parts.
Based on the mass parts of the astragalus membranaceus, the traditional Chinese medicine composition for treating adenomyosis provided by the invention comprises 1-3 parts of cinnamon, and preferably 2 parts of cinnamon.
In the invention, the cinnamon and the baked ginger have the effects of warming channels and dispelling cold, the corydalis tuber and the szechwan chinaberry fruit have the effects of regulating the flow of liver and qi and regulating qi activity, and the cinnamon, the baked ginger, the corydalis tuber and the szechwan chinaberry fruit regulate the effects of activating blood and dissolving stasis together with the other medicines.
In the invention, the components of the traditional Chinese medicine composition for treating adenomyosis are preferably 10 parts of caulis spatholobi, 10 parts of astragalus membranaceus, 10 parts of houttuynia cordata, 10 parts of patrinia, 10 parts of salvia miltiorrhiza, 4 parts of rhizoma smilacis glabrae, 3 parts of codonopsis pilosula, 3 parts of Chinese yam, 3 parts of angelica sinensis, 3 parts of semen euryales, 3 parts of radix sophorae flavescentis, 2 parts of scorpio, 2 parts of ground beetle, 3 parts of rhizoma corydalis, 3 parts of rhizoma sparganii, 3 parts of curcuma zedoary, 3 parts of bighead atractylodes rhizome, 3 parts of szechwan chinaberry fruit, 2. The traditional Chinese medicine composition has safe components and reasonable formula, does not need syndrome differentiation treatment and addition and subtraction according to symptoms, and is generally applicable; can effectively improve the leucorrhea condition, has good treatment effect on the patient with the uterine gland myopathy, does not relapse, and improves the life quality of the patient.
In the invention, the dosage form of the traditional Chinese medicine composition preferably comprises at least one of Chinese herbal medicine superfine powder capsule preparation, granules, tablets, powder and decoction, and most preferably Chinese herbal medicine superfine powder capsule preparation; the Chinese herbal medicine superfine powder capsule preparation has fixed formula and dosage form, is convenient to use and does not need to be modified according to the disease.
The invention also provides a preparation method of the Chinese herbal medicine superfine powder capsule preparation for treating adenomyosis based on the technical scheme, which comprises the following steps:
providing powder of the components in the traditional Chinese medicine composition;
carrying out superfine grinding on the powder to obtain superfine powder;
and (3) encapsulating the superfine powder to obtain the Chinese herbal medicine superfine powder capsule preparation.
In the present invention, the preparation of the powder preferably includes: the Chinese medicinal raw materials are subjected to ultraviolet disinfection, drying and crushing in sequence to obtain powder. In the invention, the ultraviolet disinfection uses a medical ultraviolet disinfection box, and medicines are put into the box and irradiated for 24 hours. The invention adopts specific conditions of ultraviolet disinfection, drying and crushing, can completely release effective substances in cells and fully exert the drug effect.
After the powder is obtained, the powder is subjected to superfine grinding to obtain superfine powder. In the present invention, the particle size of the ultrafine powder is preferably 10 μm or less. The powder obtained by the superfine grinding treatment has good solubility, dispersibility, adsorbability and chemical reaction activity, simultaneously improves the homogenization degree of each effective component, and improves the texture of the capsule preparation; the dissolution rate of the traditional Chinese medicine can be improved, so that the bioavailability of the medicine is improved, and the biological activity is retained to the maximum extent; and the release and absorption of effective components in the medicinal materials in vivo can be greatly improved, the drug effect of the Chinese medicinal preparation is improved, the dosage is reduced, the raw materials are saved, the efficiency is improved, and the cost is reduced.
After the superfine powder is obtained, the Chinese herbal medicine superfine powder capsule preparation is obtained by encapsulating the superfine powder. In the present invention, the capsule is preferably encapsulated at 0.1g to 0.5g per capsule, and more preferably at 0.3g per capsule.
The preparation method is simple, convenient to use and low in cost, has the advantage of being beneficial to reducing the dosage of the medicine, is an innovation for treating adenomyosis by traditional Chinese medicines, and has remarkable economic and social benefits. In addition, the invention adopts a specific Chinese medicine superfine grinding technology in the preparation process of the capsule preparation, thereby obviously reducing the dosage of the medicine, obviously reducing the dosage of the medicine and reducing the cost; the treatment effect is improved; the gastrointestinal reaction is obviously reduced, the preparation process is more advanced, and the method is favorable for industrial development.
The invention also provides the application of the traditional Chinese medicine composition in the technical scheme in preparing the medicine for treating adenomyosis; the dosage form of the traditional Chinese medicine composition is preferably a Chinese herbal medicine superfine powder capsule preparation, and the taking method of the Chinese herbal medicine superfine powder capsule preparation is preferably as follows: 3 times daily, 3 granules each time, orally taking, 1 month as a course of treatment, and stopping administration during menstrual period; preferably, 1-3 courses of treatment are used. During administration, no wine, strong tea, uncooked cold, and greasy diet are forbidden.
In order to further illustrate the present invention, the following examples are provided to describe the Chinese medicinal composition for treating adenomyosis, the preparation method and the application thereof in detail, but they should not be construed as limiting the scope of the present invention.
Example 1
Preparing the following materials in parts by mass: 10 parts of caulis spatholobi, 10 parts of astragalus membranaceus, 10 parts of houttuynia cordata, 10 parts of patrinia, 10 parts of salvia miltiorrhiza, 4 parts of rhizoma smilacis glabrae, 3 parts of codonopsis pilosula, 3 parts of Chinese yam, 3 parts of angelica sinensis, 3 parts of gordon euryale seed, 3 parts of radix sophorae flavescentis, 2 parts of scorpion, 2 parts of ground beetle, 3 parts of rhizoma corydalis, 3 parts of rhizoma sparganii, 3 parts of curcuma zedoary, 3 parts of bighead atractylodes rhizome, 3 parts of szechwan chinaberry fruit.
Specifically, 10g of caulis spatholobi, 10g of astragalus membranaceus, 10g of houttuynia cordata, 10g of patrinia, 10g of salvia miltiorrhiza, 4g of rhizoma smilacis glabrae, 3g of codonopsis pilosula, 3g of Chinese yam, 3g of angelica sinensis, 3g of gordon euryale seed, 3g of sophora flavescens, 2g of scorpion, 2g of ground beetle, 3g of rhizoma corydalis, 3g of rhizoma sparganii, 3g of curcuma zedoary, 3g of bighead atractylodes rhizome, 3g of szechwan chinaberry fruit, 2g of.
The composition for treating adenomyosis is prepared into a Chinese herbal medicine superfine powder capsule preparation, and the method comprises the following steps:
sterilizing caulis Spatholobi, radix astragali, herba Houttuyniae, herba Patriniae, Saviae Miltiorrhizae radix, rhizoma Smilacis Glabrae, radix Codonopsis, rhizoma Dioscoreae, radix Angelicae sinensis, semen euryales, radix Sophorae Flavescentis, Scorpio, Eupolyphaga Seu Steleophaga, rhizoma corydalis, rhizoma Sparganii, Curcumae rhizoma, Atractylodis rhizoma, fructus Toosendan, rhizoma Zingiberis Preparata and cortex Cinnamomi with ultraviolet, oven drying, and pulverizing into coarse powder to obtain powder;
carrying out traditional Chinese medicine superfine grinding on the powder by utilizing a traditional Chinese medicine superfine grinding technology to obtain superfine powder with the particle size of less than or equal to 10 microns;
and (3) filling the superfine powder into capsules according to 0.3 g/granule to obtain the Chinese herbal medicine superfine powder capsule preparation.
Example 2
The preparation method comprises the steps of preparing materials and preparing according to the mode of example 1, wherein the differences are that specifically, 10g of caulis spatholobi, 10g of astragalus membranaceus, 10g of houttuynia cordata, 10g of herba patriniae, 10g of salvia miltiorrhiza, 6g of rhizoma smilacis glabrae, 5g of codonopsis pilosula, 5g of Chinese yam, 5g of angelica sinensis, 5g of semen euryales, 5g of radix sophorae flavescentis, 3g of scorpio, 3g of ground beeltle, 5g of rhizoma corydalis, 3g of rhizoma sparganii, 3g of curcuma zedoary, 3g of bighead atractylodes rhizome.
Example 3
The preparation method comprises the steps of preparing materials and preparing according to the mode of example 1, wherein the differences are that specifically, 15g of caulis spatholobi, 15g of astragalus membranaceus, 15g of houttuynia cordata, 15g of herba patriniae, 15g of salvia miltiorrhiza, 10g of rhizoma smilacis glabrae, 8g of codonopsis pilosula, 8g of Chinese yam, 8g of angelica sinensis, 8g of semen euryales, 8g of radix sophorae flavescentis, 7g of scorpio, 7g of ground beeltle, 8g of rhizoma corydalis, 5g of rhizoma sparganii, 5g of curcuma zedoary, 5g of bighead atractylodes rhizome.
Example 4
The preparation method comprises the steps of preparing materials and preparing according to the mode of example 1, wherein the differences are that specifically, 10g of caulis spatholobi, 10g of astragalus membranaceus, 10g of houttuynia cordata, 10g of herba patriniae, 10g of salvia miltiorrhiza, 7g of rhizoma smilacis glabrae, 5g of codonopsis pilosula, 5g of Chinese yam, 5g of angelica sinensis, 5g of semen euryales, 5g of radix sophorae flavescentis, 5g of scorpio, 5g of ground beeltle, 6g of rhizoma corydalis, 3g of rhizoma sparganii, 3g of rhizoma zedoariae, 3g of rhizoma atractylodis macrocephal.
Comparative example 1
The materials were prepared and prepared as in example 1, except that no white atractylodes rhizome and no gorgon euryale seed were included.
Application example 1
The two Chinese herbal medicine ultra-fine powder capsule preparations prepared in the example 1 and the comparative example 1 are adopted for treatment verification.
1. Treatment regimens
Clinical control trials were used: the Chinese herbal medicine superfine powder capsule preparation prepared in the embodiment 1 of the invention is taken orally 3 times a day and 3 granules each time, and the dosage can be adjusted according to the pain degree of a patient. The Chinese herbal medicine superfine powder capsule preparation prepared in the comparative example 1 of the invention is taken orally 3 times a day and 3 granules each time in a control group, two groups of cases are taken according to a treatment method in the treatment period, and the curative effect evaluation is carried out after continuous taking for 3 months (except menstrual period).
2. Observation index
(1) Degree of dysmenorrhea: before treatment and 3 months after treatment, pain scoring is carried out, and the score is 0-10.
(2) And (3) quantitative scoring: before treatment and 3 months after treatment, the menstruation volume was estimated to be 5, 4,3, 2, 1 and 0 points "many, medium, few and none", respectively.
(3) CA125 (serum ovarian cancer associated antigen) level: CA125 levels, CA125 normal values were measured before and 3 months after treatment: 0 to 35U/ml.
(4) Uterine volume: before and 3 months after treatment, calculating the volume of the uterus according to an approximate ellipse formula V ═ pi/6 × a × b × c, wherein a, b and c are respectively the major diameter, the transverse diameter and the thickness diameter of the uterus measured by ultrasound (or magnetic resonance), and V is the volume.
3. Statistical treatment
The results of the clinical effects of 94 patients with mild and moderate adenomyosis in the treatment group before treatment and after 3 treatment courses are shown in table 1.
TABLE 1 therapeutic effect of the Chinese herbal medicine superfine powder capsule formulation of the present invention (n ═ 94)
Figure BDA0003022232960000091
From the above, the traditional Chinese medicine composition for treating adenomyosis provided by the invention has the outstanding characteristics of clinical practicability, and has a good clinical effect on treating adenomyosis.
The invention also compares the leucorrhea before and after the treatment of 94 patients with light and moderate adenomyosis, and the result shows that the patients taking the Chinese herbal medicine superfine powder capsule preparation prepared in the embodiment 1 of the invention feel the leucorrhea obviously reduced after taking the medicine, while the patients taking the Chinese herbal medicine superfine powder capsule preparation prepared in the comparative example 1 do not improve the leucorrhea. The invention can effectively improve the leukorrhagia condition of patients with the patient with the uterine myoglandular disease, and is worthy of further popularization in clinic.
In conclusion, the traditional Chinese medicine provided by the invention has the advantages of abundant raw materials, simple preparation method, scientific and reasonable component compatibility, effects of tonifying qi and activating blood, reducing phlegm and removing blood stasis, warming channels and dispelling cold, clearing damp and heat, and dissolving dryness and stopping leukorrhagia, has good clinical effect on patients with adenomyosis, can effectively improve the leucorrhea condition, is low in cost, good in curative effect, time-saving and labor-saving, does not have a recurrence phenomenon after treatment, has remarkable economic and social benefits, and is worthy of further popularization clinically.
Although the present invention has been described with reference to the preferred embodiments, it should be understood that various changes and modifications can be made therein by those skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.

Claims (7)

1. The traditional Chinese medicine composition for treating adenomyosis is characterized by comprising the following components in parts by mass: 5-15 parts of astragalus membranaceus, 1-8 parts of codonopsis pilosula, 2-8 parts of Chinese yam, 5-15 parts of caulis spatholobi, 5-15 parts of salvia miltiorrhiza, 2-8 parts of angelica sinensis, 1-7 parts of scorpio, 1-7 parts of ground beeltle, 2-5 parts of rhizoma sparganii, 2-5 parts of curcuma zedoary, 5-15 parts of houttuynia cordata, 5-15 parts of patrinia scabiosaefolia, 2-10 parts of rhizoma smilacis glabrae, 2-8 parts of gorgon fruit, 2-8 parts of radix sophorae flavescentis, 2-5 parts of bighead atractylodes rhizome, 2-8 parts of rhizoma corydalis, 2-5 parts of szechwan chinaberry fruit.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following components in parts by mass: 10 parts of astragalus, 3 parts of codonopsis pilosula, 3 parts of Chinese yam, 10 parts of caulis spatholobi, 10 parts of salvia miltiorrhiza, 3 parts of angelica, 2 parts of scorpion, 2 parts of ground beeltle, 3 parts of rhizoma sparganii, 3 parts of curcuma zedoary, 10 parts of houttuynia cordata, 10 parts of herba patriniae, 4 parts of rhizoma smilacis glabrae, 3 parts of gordon euryale seed, 3 parts of radix sophorae flavescentis, 3 parts of bighead atractylodes rhizome, 3 parts of rhizoma corydalis, 3 parts of szechwan chinaberry fruit, 2 parts.
3. The composition as claimed in claim 1 or 2, wherein the dosage form of the composition comprises Chinese herbal medicine superfine powder capsule, granule, tablet, powder and decoction.
4. A preparation method of a Chinese herbal medicine superfine powder capsule preparation for treating adenomyosis is characterized by comprising the following steps:
providing powders of the components of the Chinese medicinal composition of claim 1 or 2;
carrying out superfine grinding on the powder to obtain superfine powder;
and (3) encapsulating the superfine powder to obtain the Chinese herbal medicine superfine powder capsule preparation.
5. The method according to claim 4, wherein the capsule is encapsulated at 0.1 to 0.5 g/capsule.
6. The method according to claim 4, wherein the ultrafine powder has a particle size of 10 μm or less.
7. Use of the Chinese medicinal composition of any one of claims 1 to 3 or the preparation obtained by the preparation method of any one of claims 4 to 6 in the preparation of a medicament for treating adenomyosis.
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* Cited by examiner, † Cited by third party
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