CN108175026A - A kind of Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development and preparation method thereof - Google Patents
A kind of Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development and preparation method thereof Download PDFInfo
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- CN108175026A CN108175026A CN201810200141.6A CN201810200141A CN108175026A CN 108175026 A CN108175026 A CN 108175026A CN 201810200141 A CN201810200141 A CN 201810200141A CN 108175026 A CN108175026 A CN 108175026A
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- seed oil
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- silybum marianum
- solid beverage
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Classifications
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- A—HUMAN NECESSITIES
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- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
Silybum Marianum Gaertn Seed Oil solid beverage of a kind of brain tonic and intelligence development and preparation method thereof, it belongs to food processing field.The present invention mainly by milk thistle, walnut kernel, Hericium erinaceus, American Ginseng, jujube, matrimony vine, blueberry is done, VC, VE are made, parts by weight be respectively 150~200 parts milk thistle, 20~50 parts of walnut kernel, 100~150 parts of Hericium erinaceus, 20~50 parts of American Ginseng, 100~150 parts of jujube, 50~100 parts of matrimony vine, 50~80 parts of blueberry do, 0.5~5 part of VC, 0.5~5 part of VE.The compound Silybum Marianum Gaertn Seed Oil of the present invention is rich in oleic acid, linoleic acid, leukotrienes etc., the yield 28.1% of compound Silybum Marianum Gaertn Seed Oil, purity 94.4%.The present invention can adjust human immunological competence, and tranquilizing the mind qi-restoratives is capable of effective delaying human body caducity, prevent the nervous system degenerative disease that early stage Alzheimer disease etc. carries out sexual development.
Description
Technical field
The invention belongs to food processing fields；More particularly to a kind of Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development and its preparation
Method.
Background technology
With the rapid development of modern society, people is not only needed to have strong physique, it is also necessary to have good intelligence.Intelligence
Power mainly includes the elements such as learning ability, memory capability, adaptability, creativity, thinking ability, the mutual shadow of these elements
It rings, intelligence is the combined reaction of these abilities.But with advancing age, the constitution of people declines, mental retard, hypophrenia,
The performance of aging can become increasingly conspicuous.In especially living now, although many people surfaces appear to energetic, flu is all
Seldom, aging silently, central nervous system go wrong the blood vessel but in body, are mainly shown as that gradual memory hinders
Hinder, cognition dysfunction, the neuropsychic symptoms such as personality change and aphasis, seriously affect social, occupation and vital function.
In, the elderly to slow down aging, other than strengthening physical training, the adjusting being careful in one's diet is very important.
Invention content
Silybum Marianum Gaertn Seed Oil solid beverage it is an object of the present invention to provide a kind of brain tonic and intelligence development and preparation method thereof.
The invention is realized by the following technical scheme：
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development, includes the following steps：
Step 1, the milk thistle for weighing 150~200 parts respectively according to parts by weight, 20~50 parts of walnut kernel, 100~
150 parts of Hericium erinaceus, 20~50 parts of American Ginseng, 100~150 parts of jujube, 50~100 parts of matrimony vine, 50~80 parts of indigo plant
The certain kind of berries is done, 0.5~5 part of VC, 0.5~5 part of VE；
Step 2 after the load weighted milk thistle of step 1, walnut kernel cleaning, drying, is placed in micronizer and carries out powder
Broken, the granularity of mixture is 50~100 mesh after crushing, and the mixture after crushing carries out supercritical CO2Extraction, is passed through third again later
Ketone is entrainer, and acetone intake is the 0.5~0.8% of mixture quality, and the mixed gas after extraction flows into separating still and carries out
Separation, rectifying obtain compound Silybum Marianum Gaertn Seed Oil, collect remaining mixture after extraction, for use；
Step 3, by the load weighted Hericium erinaceus of step 1, after American Ginseng is respectively washed, dries, be placed in micronizer into
Row crushes, sieving, adds in ethanol solution soak extraction to the mix powder, after then residue air-dries, adds
Absolute ethyl alcohol carries out 2 ultrasonic wave extractions, merges extracting solution, the first extracting solution is obtained after ultrafiltration, for use；
Step 4, by the load weighted jujube of step 1, matrimony vine, blueberry it is dry be respectively placed in micronizer crush, 40
2~3h, sieving are dried at~60 DEG C, the granularity of mix powder is 30~60 mesh after sieving, after mixing, it is mixed to obtain first
Object is closed, for use；
Step 5, the ethanol solution that 3~5 times of quality are added in into the mixture after step 2 extraction, after stirring evenly
Microwave Extraction is carried out, it is 50~60 DEG C, 0.2~0.5h of Microwave Extraction time that solution temperature is controlled during Microwave Extraction, microwave
0.5~1.5h of mixture standing, extraction fluid, the absolute ethyl alcohol for adding in 3~5 times of quality again into mixture are molten after extraction
Liquid, 0.2~0.5h of Microwave Extraction, merges extracting solution twice again, obtains the second extracting solution, for use；
Step 6 mixes the second extracting solution made from the first extracting solution made from step 3 and step 5, crosses 200~300 mesh
After sieve, 20~30min of nitrogen is first passed through, is evaporated under reduced pressure later, recycle ethyl alcohol, obtained concentrated extract is freeze-dried, obtained
To freeze-dried mixed powder, for use；
Step 7, the compound Silybum Marianum Gaertn Seed Oil made from addition step 2 into the first mixture that step 4 obtains, stir evenly
Afterwards, stand 4~6h, then low temperature drying, crush after, add in step 6 obtain freeze-dried mixed powder, step 1 weigh VC, VE,
It is uniformly mixed, non-slurry pelletizing, vacuum packaging, the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development is made.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention, supercritical CO in step 22
20~25Mpa of extracting pressure of extraction, 38~40 DEG C of extraction temperature, CO20.45~0.5kg/h of mass flow, extraction time 0.5
~2h.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention is mixed after being sieved in step 3
The granularity for closing object powder is 100~200 mesh, is extracted as adding in the nothing of 8~10 times of quality for the first time to the mix powder
The extracting method of hydrous ethanol solution for stand 22 after stirring evenly at 20~25 DEG C~for 24 hours, second of extraction and third time carry
It is taken as adding in the ethanol solution of 4~6 times of quality again into mixture, 1~2h is extracted under conditions of ultrasonic oscillation,
Ultrasonic frequency 30KHz, the extracting solution of merging carry out ultrafiltration by the hollow cellulose film that molecular weight is 10,000, obtain first and carry
Liquid is taken, for use.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention, Microwave Extraction in step 5
Power is 500~1500W.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention is evaporated under reduced pressure in step 6
Pressure be -100~-85kPa, vacuum distillation temperature be 30~35 DEG C, the time is 20~60min, be freeze-dried in step 6
Condition be at -20 DEG C pre-freeze 2h, be placed in vacuum freeze drier, be evacuated to 10~100Pa, cold hydrazine temperature -35
~-40 DEG C, 2~12h of cooling time.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention, non-slurry pelletizing in step 7
30~40kg/cm of process setting non-slurry pelletizing oil pressure2, 6~8Hz of feeding, pelletize 8~10Hz, dry particl grain size 0.8 obtained
~1.0mm, 0.5~1.0mm of length.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention, the brain tonic and intelligence development
Silybum Marianum Gaertn Seed Oil solid beverage mainly by milk thistle, walnut kernel, Hericium erinaceus, American Ginseng, jujube, matrimony vine, blueberry is done, VC, VE are made,
Its parts by weight be respectively 150~200 parts milk thistle, 20~50 parts of walnut kernel, 100~150 parts of Hericium erinaceus, 20~50
Part American Ginseng, 100~150 parts of jujube, 50~100 parts of matrimony vine, 50~80 parts of blueberry do, 0.5~5 part of VC, 0.5
~5 parts of VE.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention, the brain tonic and intelligence development
The parts by weight of milk thistle are 150 parts in Silybum Marianum Gaertn Seed Oil solid beverage, the parts by weight of walnut kernel are 20 parts, the weight of Hericium erinaceus
Number is 100 parts, the parts by weight of American Ginseng are 20 parts, the parts by weight of jujube are 100 parts, the parts by weight of matrimony vine are 50
The parts by weight that part, blueberry are done are 50 parts, the parts by weight of VC are 0.5 part, the parts by weight of VE are 0.5 part.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention, the brain tonic and intelligence development
The parts by weight of milk thistle are 200 parts in Silybum Marianum Gaertn Seed Oil solid beverage, the parts by weight of walnut kernel are 50 parts, the weight of Hericium erinaceus
Number is 150 parts, the parts by weight of American Ginseng are 50 parts, the parts by weight of jujube are 150 parts, the parts by weight of matrimony vine are 100
The parts by weight that part, blueberry are done are 80 parts, the parts by weight of VC are 2 parts, the parts by weight of VE are 2 parts.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention, the brain tonic and intelligence development
The parts by weight of milk thistle are 170 parts in Silybum Marianum Gaertn Seed Oil solid beverage, the parts by weight of walnut kernel are 30 parts, the weight of Hericium erinaceus
Number is 120 parts, the parts by weight of American Ginseng are 30 parts, the parts by weight of jujube are 120 parts, the parts by weight of matrimony vine are 80
The parts by weight that part, blueberry are done are 60 parts, the parts by weight of VC are 1 part, the parts by weight of VE are 1 part.
A kind of milk thistle of the preparation method brain tonic and intelligence development of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention
Oily solid beverage, walnut nutritious value is very high, is known as " long live ", " Longevity ".Walnut contains abundant vitamin B and E,
Cell senescence can be prevented, brain tonic, enhancing memory and anti-aging can be divided.Walnut is also widely used in treatment neurasthenia, high blood
The illnesss such as pressure, coronary heart disease, pulmonary emphysema, stomachache, beneficial to the health of people.
A kind of milk thistle of the preparation method brain tonic and intelligence development of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention
Oily solid beverage, the hericium erinaceum polysaccharide after Hericium erinaceus extraction is most important active material in Hericium erinaceus, its active part is
The glucan that the main chain of β-(1-3) glucosides key connection and the branch of β (1-6) glucosides key connection are formed, to small white mouse sarcoma 180 and
Ehrlich ascites cancer has apparent inhibiting effect；Erinacine is the another kind of active ingredient of Hericium erinaceus.It can promote nerve growth factor
(NGF：N aixs cylinders can be extended, N cells survivals are maintained, adjust the generation of nerve cell and to the renewable hair of aged animal nerve cell
The effect of waving) synthesis, activity is much stronger than adrenaline, and main ingredient is Hericium erinaceus rhzomorph A.B.C.E.F, erinacine
Available for treatment intelelectual deterioration, neurasthenia and autonomic nerve decline, especially there is good effect to ALZheimev types and dementia
Fruit.Hericium erinaceum polysaccharide can also nourishing qi and blood, righting reinforcing is 93% to the healing effective percentage of gastric and duodenal ulcer.
A kind of milk thistle of the preparation method brain tonic and intelligence development of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention
Oily solid beverage, the Radix Panacis Quinquefolii polysaccharide after American Ginseng extraction mainly have galacturonic acid, galactolipin, glucose, arabinose, wood
Sugar, sandlwood saccharide residue etc..Radix Panacis Quinquefolii polysaccharide can be reduced blood glucose, activation tissue, be promoted with excitor nerve, dispelling fatigue, activation pancreas islet
Into it is newborn, improve it is immune, inhibit tumour, strengthen cardiac muscle, to anti anoxia, protection skin, slow down aging.Available for coronary heart disease, more
The treatment of diseases and the auxiliary treatments of tumour such as term syndrome, stealthy diabetes, neurasthenia, anaemia.
A kind of milk thistle of the preparation method brain tonic and intelligence development of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention
Oily solid beverage, jujube vitamin content is very high, there is the good reputation of " natural complex ball ", has nourishment for vitality, the work(enriched blood
Effect.Jujube warm-natured, returns spleen stomach sweet in flavor has tonifying middle-Jiao and Qi, nourishing blood and tranquilization, the function of mitigating pharmacological property；And modern pharmacology is then
It was found that contain protein, carbohydrate, organic acid, vitamin A, vitamin C, lot of trace calcium and amino acid etc. abundant for jujube
Nutrition.
A kind of milk thistle of the preparation method brain tonic and intelligence development of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention
Oily solid beverage, matrimony vine, which has, promotes immune, anti-aging, antitumor, removing free radical, antifatigue, radioresistance, liver protection, reproduction
The effects that function and protecting and improvement.
Advantageous effect：
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention, step 2 is using overcritical
CO2Compound Silybum Marianum Gaertn Seed Oil is extracted, reaction is to carry out at normal temperatures, effectively prevents heat-sensitive ingredients and chemically unstable ingredient
Oxidation and decomposition, the big property of the high density having in the supercritical state using carbon dioxide, low viscosity, diffusion coefficient,
The compound oil of milk thistle and walnut is extracted, due to the milk thistle facilitation to mix similar with walnut, improves milk thistle and core
Solubility of the active ingredient in supercritical carbon dioxide fluid in peach, so as to make the plurality of active ingredients quilt of milk thistle and walnut
It fully extracts, improves the extraction efficiency of Silybum Marianum Gaertn Seed Oil, shorten the operation cycle, 0.5~2h of extraction time, and also it is compound
The nutritive value higher of Silybum Marianum Gaertn Seed Oil, rich in oleic acid, linoleic acid, leukotrienes etc., the yield 28.1% of compound Silybum Marianum Gaertn Seed Oil, purity
94.4%.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention is made step 3 in step 6
It is evaporated under reduced pressure again after second extracting solution mixing made from the first extracting solution and step 5 obtained, is freeze-dried, obtains freeze-dried mixed
Powder is lyophilized again after extracting solution is mixed so that powder diameter is more equal after Hericium erinaceus, American ginseng extract are mixed with silymarin
It is even.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention, compound fine grinding in step 7
After Ji oil is fully infiltrated into the first mixture, then with freeze-dried mixed powder, VC, VE mixing granulation, freeze-dried mixed powder, VC, VE are coated on
The first mixture surface that compound Silybum Marianum Gaertn Seed Oil is fully infiltrated into so that the suction of the Silybum Marianum Gaertn Seed Oil solid beverage of the brain tonic and intelligence development of preparation
Receipts process is divided into three phases, absorbs the nutriment of freeze-dried mixed powder, VC, VE first, is then absorbing the first mixture
The nutritional ingredient of the compound Silybum Marianum Gaertn Seed Oil of slow release during nutriment, extends the soak time of Silybum Marianum Gaertn Seed Oil and fills
The gradually absorption process of each nutriment has been waved in distribution.
Brain tonic and intelligence development prepared by a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention
Silybum Marianum Gaertn Seed Oil solid beverage, wherein milk thistle oil colours pale yellow transparent, odorless, tasteless is nontoxic, containing a large amount of linoleic acid, in Silybum Marianum Gaertn Seed Oil
Equally containing a large amount of silymarins, milk thistle herb is clearing heat and detoxicating, liver protection, cholagogic, brain tonic.
A kind of milk thistle of the preparation method brain tonic and intelligence development of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention
Oily solid beverage, blueberry can effectively reduce cholesterol, and atherosclerosis promotes cardiovascular health；There is enhancing heart work(
Energy, pre- anti-cancer and cardiopathic effect can prevent cranial nerve aging, enhancing mental；Eyesight can be strengthened, it is tired to mitigate eyeball
Labor.
A kind of milk thistle of the preparation method brain tonic and intelligence development of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development of the present invention
Oily solid beverage, the improvement rate for taking the symptom of brains muddiness in latter 7 days reach 88%, improve within 15 days the symptom of headache, insomnia
Reach 87.2%, 82.5% can be reached by improving within 15 days forgetful symptom, and the symptom for improving anxiety can reach within 15 days
Brains muddiness symptom can all be improved after 90.1%, 30 days, headache, insomnia improvement rate reach 98.9%, and forgetful improvement rate reaches
To 98.8%, anxiety improvement rate reaches 100%, illustrates that the Silybum Marianum Gaertn Seed Oil solid beverage of present embodiment brain tonic and intelligence development being capable of brain tonic
Intelligence development, adjusts human immunological competence, tranquilizing the mind qi-restoratives, can effective delaying human body caducity, prevention early stage Alzheimer disease etc. into
The nervous system degenerative disease of row sexual development.
Specific embodiment
Specific embodiment one：
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development, includes the following steps：
Step 1, the milk thistle for weighing 150~200 parts respectively according to parts by weight, 20~50 parts of walnut kernel, 100~
150 parts of Hericium erinaceus, 20~50 parts of American Ginseng, 100~150 parts of jujube, 50~100 parts of matrimony vine, 50~80 parts of indigo plant
The certain kind of berries is done, 0.5~5 part of VC, 0.5~5 part of VE；
Step 2 after the load weighted milk thistle of step 1, walnut kernel cleaning, drying, is placed in micronizer and carries out powder
Broken, the granularity of mixture is 50 mesh after crushing, and the mixture after crushing carries out supercritical CO2Extraction, being passed through acetone again later is
Entrainer, acetone intake are the 0.5% of mixture quality, and the mixed gas after extraction flows into separating still and detached, rectifying
Compound Silybum Marianum Gaertn Seed Oil is obtained, collects remaining mixture after extraction, for use；
Step 3, by the load weighted Hericium erinaceus of step 1, after American Ginseng is respectively washed, dries, be placed in micronizer into
Row crushes, sieving, adds in ethanol solution soak extraction to the mix powder, after then residue air-dries, adds
Absolute ethyl alcohol carries out 2 ultrasonic wave extractions, merges extracting solution, the first extracting solution is obtained after ultrafiltration, for use；
Step 4, by the load weighted jujube of step 1, matrimony vine, blueberry it is dry be respectively placed in micronizer crush, 40
3h, sieving are dried at DEG C, the granularity of mix powder is 30 mesh after sieving, after mixing, obtains the first mixture, for use；
Step 5, the ethanol solution that 3 times of quality are added in into the mixture after step 2 extraction, carry out after stirring evenly
Microwave Extraction, it is 50 DEG C, Microwave Extraction time 0.2h that Microwave Extraction controls solution temperature in the process, and mixture is quiet after Microwave Extraction
.5h is set to 0, extraction fluid adds in the ethanol solution of 3 times of quality into mixture again, and Microwave Extraction 0.2h, is closed again
And extracting solution twice, the second extracting solution is obtained, for use；
Step 6 mixes the second extracting solution made from the first extracting solution made from step 3 and step 5, after crossing 200 mesh sieve,
Nitrogen 20min is first passed through, is evaporated under reduced pressure later, recycles ethyl alcohol, obtained concentrated extract is freeze-dried, obtained freeze-dried mixed
Powder, for use；
Step 7, the compound Silybum Marianum Gaertn Seed Oil made from addition step 2 into the first mixture that step 4 obtains, stir evenly
Afterwards, stand 4h, then low temperature drying, crush after, add in step 6 obtain freeze-dried mixed powder, step 1 weigh VC, VE, mixing
Uniformly, non-slurry pelletizing, vacuum packaging, the Silybum Marianum Gaertn Seed Oil solid beverage of obtained brain tonic and intelligence development.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment surpasses in step 2 and faces
Boundary CO2The extracting pressure 20Mpa of extraction, 38 DEG C of extraction temperature, CO2Mass flow 0.45kg/h, extraction time 0.5h.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment is sieved in step 3
The granularity of mix powder is 100 mesh afterwards, is extracted as adding in the absolute ethyl alcohol of 8 times of quality for the first time to the mix powder
To stand 22h at 20 DEG C after stirring evenly, second of extraction and third time are extracted as into mixture the extracting method of solution
The ethanol solution of 4 times of quality is added in again, 1h, ultrasonic frequency 30KHz are extracted under conditions of ultrasonic oscillation, is merged
Extracting solution by molecular weight be 10,000 hollow cellulose film carry out ultrafiltration, obtain the first extracting solution, for use.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment, microwave in step 5
Extraction power is 500W.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment is depressurized in step 6
The pressure of distillation is -100kPa, the temperature of vacuum distillation is 30 DEG C, time 20min, in step 6 freeze-drying condition be -
Pre-freeze 2h at 20 DEG C, be placed in vacuum freeze drier, be evacuated to 10Pa, -35 DEG C of cold hydrazine temperature, cooling time 4h.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment, dry method in step 7
Granulation process setting non-slurry pelletizing oil pressure 30kg/cm2, feeding 6Hz, pelletize 8Hz, dry particl grain size 0.8mm obtained, length
1.0mm。
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment, step 2 is using super
Critical CO2Compound Silybum Marianum Gaertn Seed Oil is extracted, reaction is to carry out at normal temperatures, effectively prevents heat-sensitive ingredients and chemically unstable
The oxidation and decomposition of ingredient, the big property of the high density having in the supercritical state using carbon dioxide, low viscosity, diffusion coefficient
Matter extracts the compound oil of milk thistle and walnut, due to the milk thistle facilitation to mix similar with walnut, improve milk thistle and
Solubility of the active ingredient in supercritical carbon dioxide fluid in walnut, so as to make the plurality of active ingredients of milk thistle and walnut
It is fully extracted out, improves the extraction efficiency of Silybum Marianum Gaertn Seed Oil, shorten the operation cycle, extraction time 0.5h, and also it is compound
The nutritive value higher of Silybum Marianum Gaertn Seed Oil, rich in oleic acid, linoleic acid, leukotrienes etc., the yield 26.1% of compound Silybum Marianum Gaertn Seed Oil, purity
91.3%.
Specific embodiment two：
It is prepared by a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to specific embodiment one
Brain tonic and intelligence development Silybum Marianum Gaertn Seed Oil solid beverage, the Silybum Marianum Gaertn Seed Oil solid beverage of the brain tonic and intelligence development is mainly by milk thistle, core
Peach kernel, Hericium erinaceus, American Ginseng, jujube, matrimony vine, blueberry are done, VC, VE are made, the Silybum Marianum Gaertn Seed Oil solid-state drink of the brain tonic and intelligence development
The parts by weight of milk thistle are 150 parts in material, the parts by weight of walnut kernel are 20 parts, the parts by weight of Hericium erinaceus are 100 parts, west
The weight that the parts by weight of American ginseng are 20 parts, the parts by weight of jujube are 100 parts, the parts by weight of matrimony vine are 50 parts, blueberry is done
Number is 50 parts, the parts by weight of VC are 0.5 part, the parts by weight of VE are 0.5 part.
Brain tonic benefit prepared by a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment
The Silybum Marianum Gaertn Seed Oil solid beverage of intelligence, male Fisher344 rats 40,20-24 monthly ages, weight 450-500g, by Fudan University
Laboratory Animal Science portion provides, and according to general international standard and method, selects Elderly people rat from aged mouse, every group 10
Only, blank group, model group, control group, present embodiment group are randomly divided into.Each group animal first measures gastric infusion by regulation, often
It is primary, and blank group, model group give normal saline gavage, and control group gives Aricept 0.525mg/kg, this embodiment party
Formula group gives the Silybum Marianum Gaertn Seed Oil solid beverage of the brain tonic and intelligence development of 100mg/kg.Completely after a week, except blank group, remaining each group left side side
The A β of 5 μ l state of aggregations of intracerebroventricular25-35Gavage is further continued for, continuous two weeks, carries out Morris water mazes in intracerebroventricular injection latter week
Behavior test, during labyrinth, 1h is administered before training.
Morris water maze Behavior tests, platform are set to labyrinth Northeast Quadrant center, and horizontal plane is higher than platform
1.5cm, water temperature are maintained at 19-20 DEG C, and rat continuously trains 4d, 2 times a day, sets longest swimming time as 120s, and record is big
The time required to mouse finds platform, platform is removed within the 5th day, records the swimming path of rat in 2min, analyzing rat is in platform quadrant
Swimming path length accounts for the percentage of total path length, and data acquisition and processing (DAP) monitors processing system automatically by Morris labyrinths image
System is completed, and test result is as shown in table 1：
1 water maze test comparison result table of table
Note：Present embodiment P compared with blank group, model group, control group<0.05
It can be, it is evident that the rat of model group injects the A β of state of aggregation by table 125-35Afterwards, in the experiment of the 1-4 days
Escape latency is considerably longer than normal group, and difference is significant；Control group is respectively less than model group with present embodiment group incubation period,
Incubation period with significant difference, and present embodiment group is significantly less than control group, present embodiment compared with the control group
Time compared with blank group in the incubation period of group is slightly less than or substantially quite, the 5th day, more normal group of model group was swum through platform quadrant
Path length account for the percentage of total path length and significantly reduce, difference is significant, control group, present embodiment group percentage
Than significantly increasing, difference is statistically significant.Pass through Morris water maze Behavior tests, it was demonstrated that one described in present embodiment
The Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development prepared by the preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of kind brain tonic and intelligence development is to rat
Inject the A β of state of aggregation25-35Recent learning memory obstacle caused by afterwards has and significantly improves.
Specific embodiment three：
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development, includes the following steps：
Step 1, the milk thistle for weighing 150~200 parts respectively according to parts by weight, 20~50 parts of walnut kernel, 100~
150 parts of Hericium erinaceus, 20~50 parts of American Ginseng, 100~150 parts of jujube, 50~100 parts of matrimony vine, 50~80 parts of indigo plant
The certain kind of berries is done, 0.5~5 part of VC, 0.5~5 part of VE；
Step 2 after the load weighted milk thistle of step 1, walnut kernel cleaning, drying, is placed in micronizer and carries out powder
Broken, the granularity of mixture is 100 mesh after crushing, and the mixture after crushing carries out supercritical CO2Extraction, being passed through acetone again later is
Entrainer, acetone intake are the 0.8% of mixture quality, and the mixed gas after extraction flows into separating still and detached, rectifying
Compound Silybum Marianum Gaertn Seed Oil is obtained, collects remaining mixture after extraction, for use；
Step 3, by the load weighted Hericium erinaceus of step 1, after American Ginseng is respectively washed, dries, be placed in micronizer into
Row crushes, sieving, adds in ethanol solution soak extraction to the mix powder, after then residue air-dries, adds
Absolute ethyl alcohol carries out 2 ultrasonic wave extractions, merges extracting solution, the first extracting solution is obtained after ultrafiltration, for use；
Step 4, by the load weighted jujube of step 1, matrimony vine, blueberry it is dry be respectively placed in micronizer crush, 60
2h, sieving are dried at DEG C, the granularity of mix powder is 60 mesh after sieving, after mixing, obtains the first mixture, for use；
Step 5, the ethanol solution that 5 times of quality are added in into the mixture after step 2 extraction, carry out after stirring evenly
Microwave Extraction, it is 60 DEG C, Microwave Extraction time 0.5h that Microwave Extraction controls solution temperature in the process, and mixture is quiet after Microwave Extraction
1.5h is put, extraction fluid adds in the ethanol solution of 5 times of quality into mixture again, and Microwave Extraction 0.5h, is closed again
And extracting solution twice, the second extracting solution is obtained, for use；
Step 6 mixes the second extracting solution made from the first extracting solution made from step 3 and step 5, after crossing 300 mesh sieve,
Nitrogen 30min is first passed through, is evaporated under reduced pressure later, recycles ethyl alcohol, obtained concentrated extract is freeze-dried, obtained freeze-dried mixed
Powder, for use；
Step 7, the compound Silybum Marianum Gaertn Seed Oil made from addition step 2 into the first mixture that step 4 obtains, stir evenly
Afterwards, stand 6h, then low temperature drying, crush after, add in step 6 obtain freeze-dried mixed powder, step 1 weigh VC, VE, mixing
Uniformly, non-slurry pelletizing, vacuum packaging, the Silybum Marianum Gaertn Seed Oil solid beverage of obtained brain tonic and intelligence development.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment surpasses in step 2 and faces
Boundary CO2The extracting pressure 25Mpa of extraction, 40 DEG C of extraction temperature, CO2Mass flow 0.5kg/h, extraction time 2h.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment is sieved in step 3
The granularity of mix powder is 200 mesh afterwards, is extracted as adding in the anhydrous second of 10 times of quality for the first time to the mix powder
To be stood at 25 DEG C for 24 hours after stirring evenly, second of extraction and third time are extracted as to mixture the extracting method of alcoholic solution
In add in the ethanol solutions of 6 times of quality again, 2h, ultrasonic frequency 30KHz are extracted under conditions of ultrasonic oscillation, is closed
And extracting solution by molecular weight be 10,000 hollow cellulose film carry out ultrafiltration, obtain the first extracting solution, for use.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment, microwave in step 5
Extraction power is 1500W.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment is depressurized in step 6
The pressure of distillation is -85kPa, the temperature of vacuum distillation is 35 DEG C, time 60min, in step 6 freeze-drying condition be -
Pre-freeze 2h at 20 DEG C, be placed in vacuum freeze drier, be evacuated to 100Pa, -40 DEG C of cold hydrazine temperature, cooling time 6h.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment, dry method in step 7
Granulation process setting non-slurry pelletizing oil pressure 40kg/cm2, feeding 8Hz, pelletize 10Hz, dry particl grain size 1.0mm obtained, long
Spend 1.0mm.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment, step 2 is using super
Critical CO2Compound Silybum Marianum Gaertn Seed Oil is extracted, reaction is to carry out at normal temperatures, effectively prevents heat-sensitive ingredients and chemically unstable
The oxidation and decomposition of ingredient, the big property of the high density having in the supercritical state using carbon dioxide, low viscosity, diffusion coefficient
Matter extracts the compound oil of milk thistle and walnut, due to the milk thistle facilitation to mix similar with walnut, improve milk thistle and
Solubility of the active ingredient in supercritical carbon dioxide fluid in walnut, so as to make the plurality of active ingredients of milk thistle and walnut
It is fully extracted out, improves the extraction efficiency of Silybum Marianum Gaertn Seed Oil, shorten operation cycle, extraction time 0.5~2h, Er Qiefu
The nutritive value higher of Silybum Marianum Gaertn Seed Oil is closed, rich in oleic acid, linoleic acid, leukotrienes etc., the yield 27.9% of compound Silybum Marianum Gaertn Seed Oil is pure
Degree 93.7%.
Specific embodiment four：
It is prepared by a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to specific embodiment one
Brain tonic and intelligence development Silybum Marianum Gaertn Seed Oil solid beverage, the Silybum Marianum Gaertn Seed Oil solid beverage of the brain tonic and intelligence development is mainly by milk thistle, core
Peach kernel, Hericium erinaceus, American Ginseng, jujube, matrimony vine, blueberry are done, VC, VE are made, the parts by weight of the milk thistle are 200 parts,
The parts by weight of walnut kernel are 50 parts, the parts by weight of Hericium erinaceus are 150 parts, the parts by weight of American Ginseng are 50 parts, jujube
The parts by weight that parts by weight are 150 parts, the parts by weight of matrimony vine are 100 parts, blueberry is done are 80 parts, the parts by weight of VC are 2
Part, the parts by weight of VE be 2 parts.
Brain tonic benefit prepared by a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment
The Silybum Marianum Gaertn Seed Oil solid beverage of intelligence, male Fisher344 rats 40,20-24 monthly ages, weight 450-500g, by Fudan University
Laboratory Animal Science portion provides, and according to general international standard and method, selects Elderly people rat from aged mouse, every group 10
Only, blank group, model group, control group, present embodiment group are randomly divided into.Each group animal first measures gastric infusion by regulation, often
It is primary, and blank group, model group give normal saline gavage, and control group gives Aricept 0.525mg/kg, this embodiment party
Formula group gives the Silybum Marianum Gaertn Seed Oil solid beverage of the brain tonic and intelligence development of 100mg/kg.Completely after a week, except blank group, remaining each group left side side
The A β of 5 μ l state of aggregations of intracerebroventricular25-35Gavage is further continued for, continuous 4 weeks, carries out acetylcholinesterase in intracerebroventricular injection latter week
(AChE, BChE), butyrylcholine esterase are tested.Because cholinergic nerve of centrum system is related with learning and memory, acetylcholine
Synthesis, acetylcholine transferase activity decline it is closely related with dementia severity, by the activity for detecting cholinesterase
To prove improvement of the drug to cholinergic nerve function.
Brain tonic benefit prepared by a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment
The Silybum Marianum Gaertn Seed Oil solid beverage of intelligence carries out AChe tests, BChE, and experimental animal continuous gavage is after 4 weeks, fasting, taboo drink before blood sampling
Then 12h is anaesthetized, abdominal aortic blood 4ml, and 3000r/min centrifugation 10min take serum, AChE tests are by serum physiology
Brine 1：9 dilutions, BchE are tested serum physiological saline 1：19 dilutions.Every milliliter of serum sample is kept the temperature 6min at 37 DEG C,
1 μm of ol matrix is operated as 1 live body unit U, sample in strict accordance with reagent disc specification in hydrolysis reaction system, 412nm,
0.5cm optical paths, the OD values of distilled water zeroing each pipe of colorimetric estimation, calculate according to formula：Test result is as shown in table 2：
2 serum cholinesterase activity contrast table of table
Note：Present embodiment P compared with blank group, model group, control group<0.05
It can be seen that more normal group of model group, serum AChE, BChE vigor increase from table 2, compared with model group, control
The activity of AChE, BChE significantly reduce in the rat blood serum of group and present embodiment group, the especially AChE of present embodiment group,
The activity of BChE significantly reduces, and illustrates a kind of preparation side of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment
The Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development prepared by method can inhibit the activity of AChE, BChE in serum, inhibit hydrolysis nerve
The hydrolysis of transmitter acetylcholine, so as to improve patient's learning and remembering ability, brain tonic and intelligence development.
Specific embodiment five：
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development, includes the following steps：
Step 1, the milk thistle for weighing 150~200 parts respectively according to parts by weight, 20~50 parts of walnut kernel, 100~
150 parts of Hericium erinaceus, 20~50 parts of American Ginseng, 100~150 parts of jujube, 50~100 parts of matrimony vine, 50~80 parts of indigo plant
The certain kind of berries is done, 0.5~5 part of VC, 0.5~5 part of VE；
Step 2 after the load weighted milk thistle of step 1, walnut kernel cleaning, drying, is placed in micronizer and carries out powder
Broken, the granularity of mixture is 80 mesh after crushing, and the mixture after crushing carries out supercritical CO2Extraction, being passed through acetone again later is
Entrainer, acetone intake are the 0.6% of mixture quality, and the mixed gas after extraction flows into separating still and detached, rectifying
Compound Silybum Marianum Gaertn Seed Oil is obtained, collects remaining mixture after extraction, for use；
Step 3, by the load weighted Hericium erinaceus of step 1, after American Ginseng is respectively washed, dries, be placed in micronizer into
Row crushes, sieving, adds in ethanol solution soak extraction to the mix powder, after then residue air-dries, adds
Absolute ethyl alcohol carries out 2 ultrasonic wave extractions, merges extracting solution, the first extracting solution is obtained after ultrafiltration, for use；
Step 4, by the load weighted jujube of step 1, matrimony vine, blueberry it is dry be respectively placed in micronizer crush, 60
2h, sieving are dried at DEG C, the granularity of mix powder is 50 mesh after sieving, after mixing, obtains the first mixture, for use；
Step 5, the ethanol solution that 4 times of quality are added in into the mixture after step 2 extraction, carry out after stirring evenly
Microwave Extraction, it is 60 DEG C, Microwave Extraction time 0.3h that Microwave Extraction controls solution temperature in the process, and mixture is quiet after Microwave Extraction
1h is put, extraction fluid adds in the ethanol solution of 4 times of quality into mixture again, and Microwave Extraction 0.5h, merges again
Extracting solution twice obtains the second extracting solution, for use；
Step 6 mixes the second extracting solution made from the first extracting solution made from step 3 and step 5, after crossing 300 mesh sieve,
Nitrogen 30min is first passed through, is evaporated under reduced pressure later, recycles ethyl alcohol, obtained concentrated extract is freeze-dried, obtained freeze-dried mixed
Powder, for use；
Step 7, the compound Silybum Marianum Gaertn Seed Oil made from addition step 2 into the first mixture that step 4 obtains, stir evenly
Afterwards, stand 5h, then low temperature drying, crush after, add in step 6 obtain freeze-dried mixed powder, step 1 weigh VC, VE, mixing
Uniformly, non-slurry pelletizing, vacuum packaging, the Silybum Marianum Gaertn Seed Oil solid beverage of obtained brain tonic and intelligence development.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment surpasses in step 2 and faces
Boundary CO2The extracting pressure 25Mpa of extraction, 40 DEG C of extraction temperature, CO2Mass flow 0.5kg/h, extraction time 1h.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment is sieved in step 3
The granularity of mix powder is 200 mesh afterwards, is extracted as adding in the anhydrous second of 10 times of quality for the first time to the mix powder
To be stood at 25 DEG C for 24 hours after stirring evenly, second of extraction and third time are extracted as to mixture the extracting method of alcoholic solution
In add in the ethanol solutions of 6 times of quality again, 2h, ultrasonic frequency 30KHz are extracted under conditions of ultrasonic oscillation, is closed
And extracting solution by molecular weight be 10,000 hollow cellulose film carry out ultrafiltration, obtain the first extracting solution, for use.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment, microwave in step 5
Extraction power is 1000W.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment is depressurized in step 6
The pressure of distillation is -85kPa, the temperature of vacuum distillation is 35 DEG C, time 60min, in step 6 freeze-drying condition be -
Pre-freeze 2h at 20 DEG C, be placed in vacuum freeze drier, be evacuated to 100Pa, -40 DEG C of cold hydrazine temperature, cooling time
12h。
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment, dry method in step 7
Granulation process setting non-slurry pelletizing oil pressure 40kg/cm2, feeding 8Hz, pelletize 10Hz, dry particl grain size 0.8mm obtained, long
Spend 0.5mm.
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment, step 2 is using super
Critical CO2Compound Silybum Marianum Gaertn Seed Oil is extracted, reaction is to carry out at normal temperatures, effectively prevents heat-sensitive ingredients and chemically unstable
The oxidation and decomposition of ingredient, the big property of the high density having in the supercritical state using carbon dioxide, low viscosity, diffusion coefficient
Matter extracts the compound oil of milk thistle and walnut, due to the milk thistle facilitation to mix similar with walnut, improve milk thistle and
Solubility of the active ingredient in supercritical carbon dioxide fluid in walnut, so as to make the plurality of active ingredients of milk thistle and walnut
It is fully extracted out, improves the extraction efficiency of Silybum Marianum Gaertn Seed Oil, shorten operation cycle, extraction time 0.5~2h, Er Qiefu
The nutritive value higher of Silybum Marianum Gaertn Seed Oil is closed, rich in oleic acid, linoleic acid, leukotrienes etc., the yield 28.1% of compound Silybum Marianum Gaertn Seed Oil is pure
Degree 94.4%.
Specific embodiment six：
It is prepared by a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to specific embodiment five
Brain tonic and intelligence development Silybum Marianum Gaertn Seed Oil solid beverage, the Silybum Marianum Gaertn Seed Oil solid beverage of the brain tonic and intelligence development is mainly by milk thistle, core
Peach kernel, Hericium erinaceus, American Ginseng, jujube, matrimony vine, blueberry are done, VC, VE are made, the parts by weight of the milk thistle are 170 parts,
The parts by weight of walnut kernel are 30 parts, the parts by weight of Hericium erinaceus are 120 parts, the parts by weight of American Ginseng are 30 parts, jujube
The parts by weight that parts by weight are 120 parts, the parts by weight of matrimony vine are 80 parts, blueberry is done are 60 parts, the parts by weight of VC are 1
Part, the parts by weight of VE be 1 part.
It is prepared by a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to specific embodiment five
Brain tonic and intelligence development Silybum Marianum Gaertn Seed Oil solid beverage, 100 volunteers are taken, and 100 volunteer's ages are 40-70 year
Between, average age 54.7 years old, 40 men, 60 Mies take 15g daily, and state recording is carried out before taking, take 7 days, 15
My god, carry out state recording after 30 days, Record Comparison is as shown in table 3：
Table 3 takes Contrast on effect table (people)
, it can be seen that taking the volunteer of the oxidation resistant Silybum Marianum Gaertn Seed Oil solid beverage of present embodiment radiation protection from table 3,
The improvement rate of the symptom of brains muddiness reaches 88% in 7 days, improves within 15 days headache, the symptom of insomnia reaches 87.2%, 15 days
82.5% can be reached by improving forgetful symptom, can be whole after the symptom for improving anxiety can reach 90.1%, 30 days within 15 days
Improve brains muddiness symptom, headache, insomnia improvement rate reach 98.9%, and forgetful improvement rate reaches 98.8%, and anxiety improvement rate reaches
To 100%, illustrate present embodiment brain tonic and intelligence development Silybum Marianum Gaertn Seed Oil solid beverage can brain tonic and intelligence development, adjust human immunity energy
Power, tranquilizing the mind qi-restoratives, the nervous system for being capable of the progress sexual development such as effective delaying human body caducity, prevention early stage Alzheimer disease are moved back
Row disease.
Specific embodiment seven：
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development, includes the following steps：
Step 1, the milk thistle for weighing 150~200 parts respectively according to parts by weight, 20~50 parts of walnut kernel, 100~
150 parts of Hericium erinaceus, 20~50 parts of American Ginseng, 100~150 parts of jujube, 50~100 parts of matrimony vine, 50~80 parts of indigo plant
The certain kind of berries is done, 0.5~5 part of VC, 0.5~5 part of VE；
Step 2 after the load weighted milk thistle of step 1, walnut kernel cleaning, drying, is placed in micronizer and carries out powder
Broken, the granularity of mixture is 50~100 mesh after crushing, and the mixture after crushing carries out supercritical CO2Extraction, is passed through third again later
Ketone is entrainer, and acetone intake is the 0.5~0.8% of mixture quality, and the mixed gas after extraction flows into separating still and carries out
Separation, rectifying obtain compound Silybum Marianum Gaertn Seed Oil, collect remaining mixture after extraction, for use；
Step 3, by the load weighted Hericium erinaceus of step 1, after American Ginseng is respectively washed, dries, be placed in micronizer into
Row crushes, sieving, adds in ethanol solution soak extraction to the mix powder, after then residue air-dries, adds
Absolute ethyl alcohol carries out 2 ultrasonic wave extractions, merges extracting solution, the first extracting solution is obtained after ultrafiltration, for use；
Step 4, by the load weighted jujube of step 1, matrimony vine, blueberry it is dry be respectively placed in micronizer crush, 40
2~3h, sieving are dried at~60 DEG C, the granularity of mix powder is 30~60 mesh after sieving, after mixing, it is mixed to obtain first
Object is closed, for use；
Step 5, the ethanol solution that 3~5 times of quality are added in into the mixture after step 2 extraction, after stirring evenly
Microwave Extraction is carried out, it is 50~60 DEG C, 0.2~0.5h of Microwave Extraction time that solution temperature is controlled during Microwave Extraction, microwave
0.5~1.5h of mixture standing, extraction fluid, the absolute ethyl alcohol for adding in 3~5 times of quality again into mixture are molten after extraction
Liquid, 0.2~0.5h of Microwave Extraction, merges extracting solution twice again, obtains the second extracting solution, for use；
Step 6 mixes the second extracting solution made from the first extracting solution made from step 3 and step 5, crosses 200~300 mesh
After sieve, 20~30min of nitrogen is first passed through, is evaporated under reduced pressure later, recycle ethyl alcohol, obtained concentrated extract is freeze-dried, obtained
To freeze-dried mixed powder, for use；
Step 7, the compound Silybum Marianum Gaertn Seed Oil made from addition step 2 into the first mixture that step 4 obtains, stir evenly
Afterwards, stand 4~6h, then low temperature drying, crush after, add in step 6 obtain freeze-dried mixed powder, step 1 weigh VC, VE,
It is uniformly mixed, non-slurry pelletizing, vacuum packaging, the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development is made.
Specific embodiment eight：
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to specific embodiment seven, step
Supercritical CO in 2220~25Mpa of extracting pressure of extraction, 38~40 DEG C of extraction temperature, CO20.45~0.5kg/h of mass flow,
0.5~2h of extraction time.
Specific embodiment nine：
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to specific embodiment seven, step
The granularity of mix powder is 100~200 mesh after being sieved in 3, is extracted as adding in 8~10 to the mix powder for the first time
The extracting method of the ethanol solution of times quality for stand 22 after stirring evenly at 20~25 DEG C~for 24 hours, extract for second
It is extracted as adding in the ethanol solution of 4~6 times of quality for the third time again into mixture, under conditions of ultrasonic oscillation
1~2h, ultrasonic frequency 30KHz are extracted, the extracting solution of merging carries out ultrafiltration by the hollow cellulose film that molecular weight is 10,000,
The first extracting solution is obtained, for use.
Specific embodiment ten：
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to specific embodiment seven, step
Microwave Extraction power is 500~1500W in 5.
Specific embodiment 11：
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to specific embodiment seven, step
The pressure being evaporated under reduced pressure in 6 is -100~-85kPa, the temperature of vacuum distillation is 30~35 DEG C, the time is 20~60min, step
In 6 be freeze-dried condition be at -20 DEG C pre-freeze 2h, be placed in vacuum freeze drier, be evacuated to 10~100Pa,
- 35~-40 DEG C of cold hydrazine temperature, 2~12h of cooling time.
Specific embodiment 12：
A kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to specific embodiment seven, step
30~40kg/cm of dry granulation setting non-slurry pelletizing oil pressure in 72, 6~8Hz of feeding, pelletize 8~10Hz, obtained dry
0.8~1.0mm of grain diameter, 0.5~1.0mm of length.
Specific embodiment 13：
It is prepared by a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to specific embodiment seven
Brain tonic and intelligence development Silybum Marianum Gaertn Seed Oil solid beverage, the Silybum Marianum Gaertn Seed Oil solid beverage of the brain tonic and intelligence development is mainly by milk thistle, core
Peach kernel, Hericium erinaceus, American Ginseng, jujube, matrimony vine, blueberry are done, VC, VE are made, and parts by weight are respectively 150~200 parts of water
Fly Ji, 20~50 parts of walnut kernel, 100~150 parts of Hericium erinaceus, 20~50 parts of American Ginseng, 100~150 parts of jujube, 50
~100 parts of matrimony vine, 50~80 parts of blueberry are done, 0.5~5 part of VC, 0.5~5 part of VE.
Take a kind of the strong of the preparation method preparation of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in present embodiment
The Silybum Marianum Gaertn Seed Oil solid beverage of brain intelligence development, the improvement rate of the symptom of brains muddiness reaches 88% in 7 days, improves within 15 days headache, loses
The symptom of dormancy reaches 87.2%, and 82.5% can be reached by improving within 15 days forgetful symptom, and the symptom for improving anxiety can within 15 days
Brains muddiness symptom can all be improved after reaching 90.1%, 30 days, headache, insomnia improvement rate reach 98.9%, forgetful improvement
Rate reaches 98.8%, and anxiety improvement rate reaches 100%, illustrates that the Silybum Marianum Gaertn Seed Oil solid beverage of present embodiment brain tonic and intelligence development can
Brain tonic and intelligence development, adjust human immunological competence, tranquilizing the mind qi-restoratives, can effective delaying human body caducity, prevent early stage Alzheimer disease
Deng the nervous system degenerative disease for carrying out sexual development.
Claims (10)
1. a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development, it is characterised in that：Include the following steps：
Step 1, the milk thistle for weighing 150~200 parts respectively according to parts by weight, 20~50 parts of walnut kernel, 100~150 parts
Hericium erinaceus, 20~50 parts of American Ginseng, 100~150 parts of jujube, 50~100 parts of matrimony vine, 50~80 parts of blueberry do,
0.5~5 part of VC, 0.5~5 part of VE；
Step 2 after the load weighted milk thistle of step 1, walnut kernel cleaning, drying, is placed in micronizer and crushes, powder
The granularity of mixture is 50~100 mesh after broken, and the mixture after crushing carries out supercritical CO2Extraction, being passed through acetone again later is
Entrainer, acetone intake are the 0.5~0.8% of mixture quality, and the mixed gas after extraction flows into separating still and detached,
Rectifying obtains compound Silybum Marianum Gaertn Seed Oil, collects remaining mixture after extraction, for use；
Step 3, by the load weighted Hericium erinaceus of step 1, after American Ginseng is respectively washed, dries, be placed in micronizer and carry out powder
Broken, sieving adds in ethanol solution soak extraction to the mix powder, after then residue air-dries, adds anhydrous
Ethyl alcohol carries out 2 ultrasonic wave extractions, merges extracting solution, the first extracting solution is obtained after ultrafiltration, for use；
Step 4, by the load weighted jujube of step 1, matrimony vine, blueberry it is dry be respectively placed in micronizer crush, 40~60
2~3h, sieving are dried at DEG C, the granularity of mix powder is 30~60 mesh after sieving, after mixing, obtains the first mixing
Object, for use；
Step 5, the ethanol solution that 3~5 times of quality are added in into the mixture after step 2 extraction, carry out after stirring evenly
Microwave Extraction, it is 50~60 DEG C, 0.2~0.5h of Microwave Extraction time that Microwave Extraction controls solution temperature in the process, Microwave Extraction
0.5~1.5h of mixture standing, extraction fluid afterwards add in the ethanol solution of 3~5 times of quality into mixture again,
0.2~0.5h of Microwave Extraction again merges extracting solution twice, obtains the second extracting solution, for use；
Step 6 mixes the second extracting solution made from the first extracting solution made from step 3 and step 5, crosses 200~300 mesh sieve
Afterwards, 20~30min of nitrogen is first passed through, is evaporated under reduced pressure later, recycles ethyl alcohol, obtained concentrated extract is freeze-dried, obtained
Freeze-dried mixed powder, for use；
Step 7 adds in compound Silybum Marianum Gaertn Seed Oil made from step 2 into the first mixture that step 4 obtains, quiet after stirring evenly
Put 4~6h, then low temperature drying, crush after, add in VC, VE that the freeze-dried mixed powder, step 1 that step 6 obtains weigh, mixing is equal
It is even, non-slurry pelletizing, vacuum packaging, the Silybum Marianum Gaertn Seed Oil solid beverage of obtained brain tonic and intelligence development.
2. a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to claim 1, it is characterised in that：
Supercritical CO in step 2220~25Mpa of extracting pressure of extraction, 38~40 DEG C of extraction temperature, CO2Mass flow 0.45~
0.5kg/h, 0.5~2h of extraction time.
3. a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to claim 1, it is characterised in that：
The granularity of mix powder is 100~200 mesh after being sieved in step 3, is extracted as adding in 8 to the mix powder for the first time
The extracting method of the ethanol solution of~10 times of quality for stand 22 after stirring evenly at 20~25 DEG C~for 24 hours, second
Extraction and third time are extracted as adding in the ethanol solution of 4~6 times of quality again into mixture, in the item of ultrasonic oscillation
1~2h, ultrasonic frequency 30KHz are extracted under part, the extracting solution of merging is surpassed by the hollow cellulose film that molecular weight is 10,000
Filter, obtains the first extracting solution, for use.
4. a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to claim 1, it is characterised in that：
Microwave Extraction power is 500~1500W in step 5.
5. a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to claim 1, it is characterised in that：
The pressure being evaporated under reduced pressure in step 6 is -100~-85kPa, the temperature of vacuum distillation is 30~35 DEG C, the time is 20~60min,
It is the pre-freeze 2h at -20 DEG C that condition is freeze-dried in step 6, be placed in vacuum freeze drier, be evacuated to 10~
100Pa, -35~-40 DEG C of cold hydrazine temperature, 2~12h of cooling time.
6. a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to claim 1, it is characterised in that：
30~40kg/cm of dry granulation setting non-slurry pelletizing oil pressure in step 72, 6~8Hz of feeding, pelletize 8~10Hz, is made
Dry particl 0.8~1.0mm of grain size, 0.5~1.0mm of length.
7. prepared by a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development described in a kind of one of claim 1-6
The Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development, it is characterised in that：The Silybum Marianum Gaertn Seed Oil solid beverage of the brain tonic and intelligence development mainly by
Milk thistle, walnut kernel, Hericium erinaceus, American Ginseng, jujube, matrimony vine, blueberry are done, VC, VE are made, and parts by weight are respectively 150~
200 parts of milk thistle, 20~50 parts of walnut kernel, 100~150 parts of Hericium erinaceus, 20~50 parts of American Ginseng, 100~150 parts
Jujube, 50~100 parts of matrimony vine, 50~80 parts of blueberry do, 0.5~5 part of VC, 0.5~5 part of VE.
8. brain tonic benefit prepared by a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to claim 7
The Silybum Marianum Gaertn Seed Oil solid beverage of intelligence, it is characterised in that：The weight of milk thistle in the Silybum Marianum Gaertn Seed Oil solid beverage of the brain tonic and intelligence development
Amount number is 150 parts, the parts by weight of walnut kernel are 20 parts, the parts by weight of Hericium erinaceus are 100 parts, the parts by weight of American Ginseng
The parts by weight that parts by weight for 20 parts, jujube are 100 parts, the parts by weight of matrimony vine are 50 parts, blueberry is done are 50 parts, VC
Parts by weight are 0.5 part, the parts by weight of VE are 0.5 part.
9. brain tonic benefit prepared by a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to claim 7
The Silybum Marianum Gaertn Seed Oil solid beverage of intelligence, it is characterised in that：The weight of milk thistle in the Silybum Marianum Gaertn Seed Oil solid beverage of the brain tonic and intelligence development
Amount number is 200 parts, the parts by weight of walnut kernel are 50 parts, the parts by weight of Hericium erinaceus are 150 parts, the parts by weight of American Ginseng
The parts by weight that parts by weight for 50 parts, jujube are 150 parts, the parts by weight of matrimony vine are 100 parts, blueberry is done are 80 parts, VC
Parts by weight be 2 parts, the parts by weight of VE are 2 parts.
10. brain tonic prepared by a kind of preparation method of the Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development according to claim 7
The Silybum Marianum Gaertn Seed Oil solid beverage of intelligence development, it is characterised in that：Milk thistle in the Silybum Marianum Gaertn Seed Oil solid beverage of the brain tonic and intelligence development
Parts by weight are 170 parts, the parts by weight of walnut kernel are 30 parts, the parts by weight of Hericium erinaceus are 120 parts, the parts by weight of American Ginseng
Number is 30 parts, the parts by weight of jujube are 120 parts, the parts by weight that the parts by weight of matrimony vine are 80 parts, blueberry is done are 60 parts, VC
Parts by weight be 1 part, the parts by weight of VE are 1 part.
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| CN201810200141.6A CN108175026A (en) | 2018-03-12 | 2018-03-12 | A kind of Silybum Marianum Gaertn Seed Oil solid beverage of brain tonic and intelligence development and preparation method thereof |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1463970A (en) * | 2002-06-12 | 2003-12-31 | 中国科学院山西煤炭化学研究所 | Process for preparing silymarin |
| CN101759687A (en) * | 2009-10-20 | 2010-06-30 | 苏州派腾生物医药科技有限公司 | Method for preparing Silymarin |
| CN102499411A (en) * | 2011-11-03 | 2012-06-20 | 南昌大学 | Liver nourishing/protecting beverage and preparation method thereof |
| CN104432329A (en) * | 2014-12-12 | 2015-03-25 | 上海塞翁福农业发展有限公司 | Hericium erinaceus-red jujube-Chinese wolfberry beverage and preparation method thereof |
| CN104651037A (en) * | 2014-01-17 | 2015-05-27 | 吴长军 | Method for extracting oil and protein in silybum marianum kernels by subcritical fluid |
| CN106108009A (en) * | 2016-06-24 | 2016-11-16 | 周口师范学院 | Herba Cirsii extracting solution, health product containing Herba Cirsii active component and preparation method thereof |
| CN107412085A (en) * | 2017-03-30 | 2017-12-01 | 广东神石生物科技有限公司 | A kind of dendrobium candidum toothpaste and preparation method thereof |
-
2018
- 2018-03-12 CN CN201810200141.6A patent/CN108175026A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1463970A (en) * | 2002-06-12 | 2003-12-31 | 中国科学院山西煤炭化学研究所 | Process for preparing silymarin |
| CN101759687A (en) * | 2009-10-20 | 2010-06-30 | 苏州派腾生物医药科技有限公司 | Method for preparing Silymarin |
| CN102499411A (en) * | 2011-11-03 | 2012-06-20 | 南昌大学 | Liver nourishing/protecting beverage and preparation method thereof |
| CN104651037A (en) * | 2014-01-17 | 2015-05-27 | 吴长军 | Method for extracting oil and protein in silybum marianum kernels by subcritical fluid |
| CN104432329A (en) * | 2014-12-12 | 2015-03-25 | 上海塞翁福农业发展有限公司 | Hericium erinaceus-red jujube-Chinese wolfberry beverage and preparation method thereof |
| CN106108009A (en) * | 2016-06-24 | 2016-11-16 | 周口师范学院 | Herba Cirsii extracting solution, health product containing Herba Cirsii active component and preparation method thereof |
| CN107412085A (en) * | 2017-03-30 | 2017-12-01 | 广东神石生物科技有限公司 | A kind of dendrobium candidum toothpaste and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 国家食品药品监督管理局，广东省食品药品监督管理局编: "《企业食品安全管理》", 30 June 2008, 中国医药科技出版社 * |
| 曾剑锋等: "水飞蓟素临床应用的研究进展 ", 《医学综述》 * |
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Application publication date: 20180619 |