CN106376933A - Brain-invigorating antioxidant health product and applications thereof - Google Patents
Brain-invigorating antioxidant health product and applications thereof Download PDFInfo
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- CN106376933A CN106376933A CN201610770493.6A CN201610770493A CN106376933A CN 106376933 A CN106376933 A CN 106376933A CN 201610770493 A CN201610770493 A CN 201610770493A CN 106376933 A CN106376933 A CN 106376933A
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- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 26
- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 26
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- 241000928579 Malania oleifera Species 0.000 claims abstract description 49
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- 238000002360 preparation method Methods 0.000 claims abstract description 6
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- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 3
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- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
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- 230000000877 morphologic effect Effects 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B1/00—Production of fats or fatty oils from raw materials
- C11B1/10—Production of fats or fatty oils from raw materials by extracting
- C11B1/106—Production of fats or fatty oils from raw materials by extracting using ultra-sounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A brain-invigorating antioxidant health product is composed of the following components in percentage by weight: 60 to 75% of malania oleifera oil, 10 to 20% of peony seed oil, 1 to 5% of natural VE with a purity of 80%, and 5 to 15% of DHA algae oil. The invention also discloses applications of the brain-invigorating antioxidant health product in the preparation of health product for preventing Alzheimer's disease or brain function degradation, acetylcholin esterase inhibitor, and functional food. The peony seed oil is prepared from Shangri-La Yunnan peony and paeonia ostii. The health product has dual health functions of malania oleifera oil and peony seed oil, can improve the activity of cranial nerves and prevent encephalasthenia, can also treat cardiovascular diseases and autoimmune diseases, and can be used as blood nutrient, vitamin F, or plant DHA. The health product has an important health value for people who need the nutrient and health functions.
Description
Technical field
The invention belongs to technical field of health care food is and in particular to a kind of antioxidant functional food and its application.
Background technology
Malania oleifera also known as hedgehog hydnum fruit, mountain paulownia fruit etc., are that Olacaceae Herba Kalimeridis wood belongs to unique Relict Plant, are Chinese the eastern regions of the Yunnan Province
South and the distinctive rareness species in the western karst in osmanthus ground mountain region, are Chinese Second Class Key Protected Plant, it is distributed in the wide of southeastern Yunnan
The Limestone Mountain Areas of the 500-1640m such as south, Funing and West Guangxi, are the important afforestation in karst seeds, are to pass again
The edible oil plant of system, has huge Ecosystem Service and high economic worth.The Malania Oleifera Oil extracting from malania oleifera contains
There is 40%～60% tetracosa carbon -15- olefin(e) acid, be a kind of long-chain monounsaturated fatty acid, because it is from shark brain, cattle earliest
Separate in brain and gain the name, tetracosa carbon -15- olefin(e) acid is brain development, the required nutrient maintaining, to raising cranial nerve
Enliven, prevent cerebral neurastheria from playing a very important role；Cardiovascular and human autoimmune's shortage property disease are also had fairly good
Curative effect.
P. delavayi pattern is gorgeous, and having rare yellow flower in Tree Peony Cultivars is genetic resourceses, is Cultivated tree peonies choosing
Educate the important parental source that yellow flower is new varieties.P. delavayi pattern variation type enriches, and except yellow, (or petal base portion has purple
Speckle) outward, also green, yellow green, orange, pink colour, aubergine, black purple etc., larger black purple in plant part petal base portion
Allochromatic colour fringing, green color stripe etc. in speckle, edge, are the important germ plasm resource cultivating Flower New Variety kind.Additionally, its root bark also has
Have important medical value, its cold in nature, sour-acrid taste, root bark be used for clearing away heat and cooling blood, control haematemesis, hematuria, dysentery, dysmenorrhea etc., also by
Medicinal as Cortex Moutan, central nervous system can be suppressed, have expansion coronary vasodilator, blood pressure lowering, the antibacterial, function such as antiinflammatory, anticoagulation, be
Extract the important source material of different kind organism active substance, there is exploitation prospect.In recent years research display peony seed oil has pole
High nutritive value, is the fabulous raw material that high-grade edible oil and health product produce.In March, 2011 ratifies Paeonia suffruticosa through health ministry
Seed oil, as new resource food, enters edible oil ranks, causes great attention.Through experimental tests Paeonia suffruticosa seed oil content reaches
20%, wherein unsaturated fatty acid content is up to 85%, and-linolenic acid content reaches 35%, is 140 times of olive oil.Alpha-linolenic acid
It is to constitute human body brain cell and histiocytic important component, being that human body is indispensable itself can not synthesize and irreplaceable
Polyunsaturated fatty acid, has the title of " hemotrophic nutrition element ", " vitaminF " and " plant NAOHUANGJIN " again.Therefore, peony seed oil is for I
Excellent edible oil resource in the new food resource of state.
Paeonia suffruticosa does not only have high ornamental value, also considerable medical value.Moutan root bark is used as medicine, and name is said " red
Skin ", Cortex Moutan has and purifies the blood, and the function of promoting blood circulation to remove blood stasis is clinically mainly used in clearing away liver-fire and cool the blood dissipate blood stasis (antiinflammatory, blood pressure lowering).Male
Red seed oil has very high nutritive value, by the toxicological assessment of health ministry, Ministry of Public Health 2011 the 9th
Number bulletin approval peony seed oil as new resource food, be that the edible exploitation of peony seed oil provides Fundamentals of Law.Peony seed oil
It is with peony seeds benevolence as raw material, make through techniques such as squeezing, decolouring, deodorizes, containing substantial amounts of linolenic acid, linoleic acid and oil
The unsaturated fatty acids such as acid.In numerous unsaturated fatty acids, linolenic acid is a kind of polyunsaturated fatty acid of ω -3 series,
It is also a kind of essential fatty acid that human body can not itself synthesize. Oleic acid is then referred to as " safe fats acid ", is effectively reduced gallbladder solid
Deposition on blood vessel for the alcohol, has the effects such as prevention of arterial hardening, particularly important to the health of cardiovascular and cerebrovascular vessel. and linoleic acid is a kind of
ω -6 series polyunsaturated fatty acid, has the suppression synthesis of cholesterol in human body, antioxidation, anticancer, prevention diabetes etc. to make
With.Therefore Paeonia suffruticosa not only has high ornamental value, and its oil resource value and medical value have also obtained widely
Develop and use.Low serious plus pest and disease damage yet with P. delavayi seed-setting rate, so P. delavayi is planted in its natural state
Sub- emergence rate is extremely low, and sexual propagation is difficult.And Seedling Populations rare numbers under natural conditions, human activity interference is as artificially in addition
The reasons such as excavation, tourism development, reclamation of wasteland arable land make its habitat constantly be nibbled, and habitat is seriously damaged, and germ plasm resource is anxious
Reduce sharply few.Therefore study in the urgent need to the protection to P. delavayi wild resource with Application way.P. delavayi is as one
Wild stockss, have and have stronger adaptability to ecological environment, have Morphological Diversity and genetic diversity, asexual multiplication ability
By force, the advantages of efficiency high, it is that the exploitation of P. delavayi provide practical basis.
At present, there are no the diligent valence value of Related Drug, the report of oil resource value of P. delavayi in prior art, more do not have
Have and reasonably develop and useedd, also Malania Oleifera Oil and peony seed oil composition are not had the health care food of collaborative health-care effect
The report of product formula.
Content of the invention
It is an object of the invention to provide a kind of antioxidant functional food is by Malania Oleifera Oil, peony seed oil, purity 80% day
So VE and purity 40%DHA algae oil are formed, and have the synergism of antioxidation and anti-cardiovascular disease.
In order to realize the above-mentioned purpose of the present invention, the invention provides following technical scheme：
Brain-strengthening antioxidant health-care product, by weight percentage this health product are made up of following components：
Malania Oleifera Oil 60%-75%, peony seed oil 10-20%, purity 80% natural VE 1%-5%, purity 40%DHA
Algae oil 5%-15%.
According to described brain-strengthening antioxidant health-care product, wherein Malania Oleifera Oil be 70%-75%, peony seed oil be 20-30%,
Purity 80% natural VE be 1%-3%,.
According to described brain-strengthening antioxidant health-care product, wherein Malania Oleifera Oil be 71.1%, peony seed oil be 17%, purity
80% natural VE is 1.9%, purity 40%DHA algae oil is 10%.
The preparation method of brain-strengthening antioxidant health-care product, the Malania Oleifera Oil in described anti-health product is to be prepared by following methods
And obtain：Take malania oleifera kernel, pulverize, cross 20-40 mesh sieve, high temperature steaming 20-30 minute, by liquid ratio 1:3-5V:V, g:ML adds
Enter edible ethanol, ultrasonic assistant extracts 30-40min, ultrasonic power 120-150W, and ultrasonic temperature is 30-40 DEG C, ultrasonic carry
Take 2-3 time, sucking filtration, merging filtrate, in 40-50 DEG C of concentrating under reduced pressure, remove solvent and obtain Malania Oleifera Oil.
The preparation method of described brain-strengthening antioxidant health-care product, the peony seed oil in described anti-health product is by following sides
Method is prepared：Take P. delavayi seed screen after naturally drying in the shade, shell, being dried, pulverize after cross 60 mesh sieves obtain P. delavayi seed powder,
Carry out supercritical carbon dioxide extraction, extraction conditionss are：Extraction time 60min, 40 DEG C of temperature, pressure 45MPa, CO2 flow
20kg/h；Or take P. delavayi seed powder to carry out cold pressing, 30 DEG C of cold pressing temperature, cold pressing pressure 60MPa, cold pressing time 2h；Or take Yunnan male
Red seed powder carries out surname extraction, and Extraction solvent is petroleum ether, screen size 60 mesh, 70 DEG C of Extracting temperature, and solid-to-liquid ratio is 1:30.
Described brain-strengthening antioxidant health-care product is in the health product preparing anti-senile dementia disease or anti-cerebral functional deterioration disease
Application.
Application in preparing acetylcholinesteraseinhibitors inhibitors for the described brain-strengthening antioxidant health-care product.
Application in preparing functional food for the described brain-strengthening antioxidant health-care product.
According to described brain-strengthening antioxidant health-care product, it is male that Shangri-la Yunnan taken from by the raw material of wherein said peony seed oil
Red.
According to described brain-strengthening antioxidant health-care product, P. delavayi taken from by the raw material of wherein said peony seed oil and Paeonia ostii is male
Red.
Patent and document report with regard to Malania Oleifera Oil are as follows.Invention disclosed patent " a kind of supercritical CO in 20142Liquid
The method that body extracts Malania Oleifera Oil " adopts supercritical extraction Malania Oleifera Oil, but the method high cost, equipment investment are high, uncomfortable
For industrial mass production, and Malania Oleifera Oil viscosity is larger, and many at normal temperatures exist in solid form, therefore, shooting flow
Body abstraction technique is difficult to by Malania Oleifera Oil extraction completely.In addition, also on " Malania Oleifera Oil preparation biodiesel ", " malania oleifera
The Patents report of fruit pulp extraction quintessence oil ", but the patent of health product is prepared with regard to Malania Oleifera Oil and P. delavayi oil compatibility
Have no report.
Compared with prior art, the present invention possesses following excellent benefit：The health product of the present invention have Malania Oleifera Oil and male
Red seed oil double health effect, both can be to improving enlivening, preventing cerebral neurastheria from playing a very important role of cranial nerve, Bulbus Allii
It is rich in nervonic acid, nervonic acid is the unique specific drug treating senile dementia at present in fruit oil.And Malania Oleifera Oil is as the present invention
Main component, in malania oleifera, neural acid content is 25%, is significantly larger than the plant that other contain nervonic acid composition, therefore this
Bright main feature is enriched in nervonic acid, for hypomnesis, does not have enough sleep, and often stays up late, subhealth state that operating pressure is big
Crowd has good relieving mental strain and helping sleep, the effect of memory reinforcing；Middle-aged and elderly people for hypomnesis, cell senescence can improve
Memory, the generation of prevention senile dementia.Additionally since the another one main component P. delavayi oil of the present invention, mainly it is rich in
Linoleic acid plus linolenic acid, energy vessel softening, lacking property disease to cardiovascular and human autoimmune also has goodish curative effect, also
Can be used as the nutrition health-care functions of " hemotrophic nutrition element ", " vitaminF " and " plant NAOHUANGJIN ".To need simultaneously supplement above-mentioned battalion
Support and the crowd of health care has important health value.
The present invention adopts ultrasonic assistant from Malania oleifera to oily extraction, with food grade ethanol for extracting solvent to Bulbus Allii
Fruit seed kernel oil is extracted, and can extract the oils and fatss in Malania oleifera to greatest extent, this extraction process compared with traditional method,
There are oils and fatss and improve extraction efficiency, shorten extraction time it is not necessary to main equipment can complete the extraction of oil, the method sets simultaneously
Standby and reagent input cost is low, simple to operate, onestep extraction, no waste liquor contamination, and residual residue is alternatively arranged as extracting protein, many
The raw material of sugar, is the optimum extracting method comparing the extraction Malania Oleifera Oil confirming after multiple methods at present.
The present invention prepares peony seed oil with P. delavayi Fruit pod and kind skin for raw material, turns waste into wealth, and is that the synthesis of P. delavayi is closed
Reason develops provides Technical Reference, has important protection of resources to the Reasonable Protection of P. delavayi and the utilization of resources of P. delavayi
With environmental conservation meaning.
Brief description
Fig. 1 is P. delavayi seed oil gas chromatogram total ion current figure；
Fig. 2 is the time effect curve figure that DPPH free radical removed by P. delavayi seed oil；
Fig. 3 removes the dose effect curve figure of DPPH free radical for peony seed oil.
Specific embodiment：
Below in conjunction with the accompanying drawings, further illustrate the essentiality content of the present invention with embodiments of the invention, but not with
This is limiting present disclosure.
Embodiment 1：
Malania Oleifera Oil 700g, P. delavayi oil 295g, vitamin e1 0g mix homogeneously, it is heated to 40 DEG C, constant temperature preserves, adopt
Pressed film method prepares soft capsule, soft capsule 2000, every 250mg is obtained altogether, wherein neural acid content is 43.75mg/ grain.
Wherein Malania Oleifera Oil is prepared by following methods：Take malania oleifera kernel, pulverize, cross 20-40 mesh sieve, high temperature steaming
20-30 minute, by liquid ratio 1:3-5V:V, g:ML adds edible ethanol, and ultrasonic assistant extracts 30-40min, ultrasonic power
120-150W, ultrasonic temperature is 30-40 DEG C, supersound extraction 2-3 time, sucking filtration, merging filtrate, in 40-50 DEG C of concentrating under reduced pressure, removes
Solvent obtains Malania Oleifera Oil.
Peony seed oil is prepared by following methods：Take P. delavayi seed screen after naturally drying in the shade, shell, being dried, powder
Cross 60 mesh sieves after broken and obtain P. delavayi seed powder, carry out supercritical carbon dioxide extraction, extraction conditionss are：Extraction time 60min, temperature
40 DEG C, pressure 45MPa, CO2Flow 20kg/h；
Or, take P. delavayi seed, 30 DEG C of cold pressing temperature, cold pressing pressure 60MPa, cold pressing time 2h.
Embodiment 2：
Malania Oleifera Oil 300g, P. delavayi oil 200g, add Lactose, Microcrystalline Cellulose, starch, hydroxypropyl cellulose etc. auxiliary
Material, prepares wet granular, crosses No. 9 sieves, 30min, granulate is dried, loads in No. 0 capsule shells, make after being repeatedly dried in 60 DEG C of baking ovens
1000, every 500mg, wherein neural acid content is 35.12%.
Malania Oleifera Oil, peony seed oil are obtained by embodiment 1 methods described.
Embodiment 3：
The Malania Oleifera Oil being extracted for investigating the present invention further resists the curative effect of senile dementia, and the present invention is according to choline
Theory can be damaged, measure the anti-acetylcholinesterase activity of different anti senile dementia drugs and Malania Oleifera Oil of the present invention.By body
Outer mensure medicine the suppression ratio of acetylcholinesterase is proved its have functions that the cerebral functional deterioration disease such as anti-senile dementia with
Effect (being shown in Table 1).The present invention develops extraction natural plant Malania Oleifera Oil as one kind safely and efficiently function from malania oleifera
Property food, supplement human brain necessary to functional materials be one of inevitable choice of mankind nowadays brain health.
Table 1 Malania Oleifera Oil, Radix Polygalae total saponins, the suppression ratio to acetylcholinesterase for the huperzine A
| Sample ID | Extracting method | Concentration | AchE suppression ratio (%) |
| Malania Oleifera Oil | Ultrasonic extraction | 1mg mL-1 | 88.62±0.23 |
| Radix Polygalae | Water extraction total saponins | 1mg mL-1 | 72.75±1.13 |
| Huperzine A | Street drug | 1mg mL-1 | 93.45±2.08 |
Embodiment 4：
For investigating clinical efficacy and the safety of the present invention further, select 30 curative effects to functional food of the present invention
Carry out clinical observation.The formula therapeutic effect standard of the embodiment of the present invention 1 and 2：Cure：No forgetful, memory recovers normal.Good
Turn：Forgetful obvious mitigation.Do not heal：Forgetful be not improved, memory is no clearly better.Through treatment 30, cure 24, take a turn for the better
4, not more 2, total effective rate 93%.There is no any side effect and untoward reaction.
Embodiment 5：
The confection of suitable middle-aged and elderly people is prepared into for main component with Malania Oleifera Oil and peony seed oil：
Brain-strengthening Sugar Sphere：Malania Oleifera Oil 1-10% and peony seed oil 1-10%, citric acid 0.1 1.0%, vegetable oil 0.1
1.0%, white sugar 20 40%, maltose syrup is supplemented to 100%.Maltose is heated, melts, addition white sugar, vegetable oil,
Adjust acidity and mouthfeel with citric acid, finally with the nervonic acid of vegetable oil dissolving, pour mould into, cooling, obtain final product.
Embodiment 6：
Inventive formulation antioxidation activity in vitro is tested：
By inventive formulation compositionss (Malania Oleifera Oil 60%-75%, peony seed oil 10-20%, purity 80% natural VE
1%-5%, purity 40%DHA algae oil 5%-15%), Malania Oleifera Oil respectively with DPPH (final concentration of 100 μM) hybrid reaction, if
Fixed 3 repeating holes, arrange the not blank of drug containing and Trolox positive control simultaneously, 30 DEG C, 1h, and microplate reader measures OD
Value, Detection wavelength is 515nm.It is calculated antioxygen rate.
Table 10 antioxidation activity in vitro result of the present invention
Claims (10)
1. brain-strengthening antioxidant health-care product, by weight percentage this health product are made up of following components：
Malania Oleifera Oil 60%-75%, peony seed oil 10-20%, purity 80% natural VE 1%-5%, purity 40%DHA algae oil
5%-15%.
2., according to the brain-strengthening antioxidant health-care product described in claim 1, wherein Malania Oleifera Oil is that 70%-75%, peony seed oil are
15-20%, purity 80% natural VE are 1%-3%, purity 40%DHA algae oil is 5%-10%.
3., according to the brain-strengthening antioxidant health-care product described in claim 1 or 2, wherein Malania Oleifera Oil is that 71.1%, peony seed oil is
17%th, purity 80% natural VE be 1.9%, purity 40%DHA algae oil be 10%.
4. the preparation method of the brain-strengthening antioxidant health-care product described in claim 1 is it is characterised in that in described anti-health food
Malania Oleifera Oil be to be prepared by following methods：Take malania oleifera kernel, pulverize, cross 20-40 mesh sieve, high temperature steaming 20-30 divides
Clock, by liquid ratio 1:3-5V:V, g:ML adds edible ethanol, and ultrasonic assistant extracts 30-40min, ultrasonic power 120-
150W, ultrasonic temperature is 30-40 DEG C, supersound extraction 2-3 time, sucking filtration, merging filtrate, in 40-50 DEG C of concentrating under reduced pressure, removes solvent
Obtain Malania Oleifera Oil.
5. the preparation method of the brain-strengthening antioxidant health-care product described in claim 1 is it is characterised in that in described anti-health food
Peony seed oil be to be prepared by following methods：After taking P. delavayi seed screen after naturally drying in the shade, shell, being dried, pulverizing
Cross 60 mesh sieves and obtain P. delavayi seed powder, carry out supercritical carbon dioxide extraction, extraction conditionss are：Extraction time 60min, temperature 40
DEG C, pressure 45MPa, CO2 flow 20kg/h；Or take P. delavayi seed powder to carry out cold pressing, and 30 DEG C of cold pressing temperature, cold pressing pressure 60MPa,
Cold pressing time 2h；Or taking P. delavayi seed powder to carry out surname extraction, Extraction solvent is petroleum ether, screen size 60 mesh, Extracting temperature
70 DEG C, solid-to-liquid ratio is 1:30.
6. the brain-strengthening antioxidant health-care product described in claim 1 or 2 or 3 is preparing anti-senile dementia disease or anti-cerebral functional deterioration disease
Health product in application.
7. application in preparing acetylcholinesteraseinhibitors inhibitors for the brain-strengthening antioxidant health-care product described in claim 1 or 2 or 3.
8. application in preparing functional food for the brain-strengthening antioxidant health-care product described in claim 1 or 2 or 3.
9. according to the brain-strengthening antioxidant health-care product described in claim 1 or 2 or 3 it is characterised in that described peony seed oil former
Shangri-la P. delavayi taken from by material.
10. according to the brain-strengthening antioxidant health-care product described in claim 1 or 2 or 3 it is characterised in that described peony seed oil former
Material takes from P. delavayi and Paeonia ostii Paeonia suffruticosa.
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Inventor after: Chen Qiu Inventor after: Liu Xiangyi Inventor after: Shi Rui Inventor before: Yang Yuming Inventor before: Wang Juan Inventor before: Liu Xiangyi Inventor before: Shi Rui Inventor before: Chen Qiu |
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Application publication date: 20170208 |