CN107125532A - A kind of polygonatum Solomon's seal effervescence granular - Google Patents
A kind of polygonatum Solomon's seal effervescence granular Download PDFInfo
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- CN107125532A CN107125532A CN201710381528.1A CN201710381528A CN107125532A CN 107125532 A CN107125532 A CN 107125532A CN 201710381528 A CN201710381528 A CN 201710381528A CN 107125532 A CN107125532 A CN 107125532A
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- China
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- parts
- seal
- raw material
- effervescence granular
- auxiliary material
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- 241000756042 Polygonatum Species 0.000 title claims abstract description 35
- 239000002994 raw material Substances 0.000 claims abstract description 42
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 32
- 239000000463 material Substances 0.000 claims abstract description 28
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 21
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 21
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000001630 malic acid Substances 0.000 claims abstract description 21
- 235000011090 malic acid Nutrition 0.000 claims abstract description 21
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims abstract description 20
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 20
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims abstract description 20
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims abstract description 20
- 239000008101 lactose Substances 0.000 claims abstract description 20
- 244000276331 Citrus maxima Species 0.000 claims abstract description 18
- 235000001759 Citrus maxima Nutrition 0.000 claims abstract description 18
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 18
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- 239000008273 gelatin Substances 0.000 claims abstract description 18
- 235000019322 gelatine Nutrition 0.000 claims abstract description 18
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- 244000126002 Ziziphus vulgaris Species 0.000 claims abstract description 8
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
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- 238000000605 extraction Methods 0.000 claims description 10
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 4
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- 229910052708 sodium Inorganic materials 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims description 2
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- 230000001835 salubrious effect Effects 0.000 abstract description 4
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract description 2
- 238000003860 storage Methods 0.000 abstract description 2
- 230000002929 anti-fatigue Effects 0.000 description 17
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- 238000002474 experimental method Methods 0.000 description 7
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 235000013339 cereals Nutrition 0.000 description 4
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- 239000003963 antioxidant agent Substances 0.000 description 3
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- 238000002386 leaching Methods 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 238000010926 purge Methods 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- 241001251949 Xanthium sibiricum Species 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
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- 238000005516 engineering process Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
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- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
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- 235000002906 tartaric acid Nutrition 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241001061264 Astragalus Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010010144 Completed suicide Diseases 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
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- 229910052742 iron Inorganic materials 0.000 description 1
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- 230000004089 microcirculation Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
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- 230000007170 pathology Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A kind of polygonatum Solomon's seal effervescence granular, it is prepared from by following raw material and auxiliary material, raw material：Sealwort, radix polygonati officinalis, the Radix Astragali, donkey-hide gelatin, Chinese yam, Poria cocos, shaddock grunt, jujube, matrimony vine part, white fungus, asparagus；Auxiliary material：Sodium acid carbonate, malic acid, lactose, hydroxypropyl cellulose, sodium chloride, maltodextrin.Compared with prior art, formula is simple, reasonable by the present invention, and taste is sweet, salubrious tasty, the convenient storage of product and carrying, it is prevented from caking, it is instant fast, it is on probation by user, can in a short time rapid recovery fatigue, recover complexion, mitigate DOMS, effect is obvious, simultaneously also have nourishing yin to moisten dryness, promote the production of body fluid to quench thirst, yin-nourishing green blood, improve immunity, the effects such as soothing nerves and assisting sleep is slept.
Description
Technical field
The present invention relates to a kind of food processing technology field, and in particular to a kind of polygonatum Solomon's seal effervescence granular.
Background technology
With the development of society, the work rhythm of people is accelerated, life stress constantly increases, and causes people's life easy
Fatigue, so that, the body of many people is in sub-health state.And the sense of fatigue of modern is frequently not single factors causes
, but comprehensive fatigue caused by many reasons such as pathology, physiology, psychology.Think in traditional Chinese medicine, fatigue is by psychology
Fluctuations and member are risen caused by the dual reason of consume.Fatigue increasingly affects the normal work and study of people and body is strong
Health, for fatigue-relieving, occurs in that many antifatigue products on the market, and anti-fatigue beverage is exactly a wherein important class.
At present, more than anti-fatigue beverage based on liquid beverage, and antifatigue effervescence granular is in initial stage, and existing
Most of easy deliquescence caking of antifatigue effervescence granular, dissolution velocity are slow, in antifatigue aspect effect of all You nothing substantial,
All can not be simultaneously to carrying out tired alleviation in terms of the spleen of people, liver, kidney, the heart.Therefore, need to be to conventional formulation and preparation method
It is improved.
The content of the invention
The purpose of the present invention is that provides a kind of polygonatum Solomon's seal effervescence granular to solve the deficiencies in the prior art.
The purpose of the present invention is realized with following technical proposals：
A kind of polygonatum Solomon's seal effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：47-53 parts of sealwort, 97-103 parts of radix polygonati officinalis, 57-63 parts of the Radix Astragali, 27-33 parts of donkey-hide gelatin, 27-33 parts of Chinese yam, Fu
17-23 parts of Siberian cocklebur, 7-13 parts of shaddock grunt, 7-13 parts of jujube, 17-23 parts of matrimony vine, 12-18 parts of white fungus, 6-8 parts of asparagus；
Auxiliary material：40-50 parts of sodium acid carbonate, 40-50 parts of malic acid, 280-300 parts of lactose, 10-12 parts of hydroxypropyl cellulose,
8-12 parts of sodium chloride, 4-6 parts of maltodextrin.
It is preferred that, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：50 parts of sealwort, 100 parts of radix polygonati officinalis, 60 parts of the Radix Astragali, 30 parts of donkey-hide gelatin, 30 parts of Chinese yam, 20 parts of Poria cocos, shaddock grunt 10
Part, 10 parts of jujube, 20 parts of matrimony vine, 15 parts of white fungus, 7 parts of asparagus；
Auxiliary material：45 parts of sodium acid carbonate, 45 parts of malic acid, 290 parts of lactose, 11 parts of hydroxypropyl cellulose, 10 parts of sodium chloride, wheat
5 parts of bud dextrin.
The preparation method of polygonatum Solomon's seal effervescence granular as described above, comprises the following steps：
(1) prepared by raw material extraction stiff paste：Above-mentioned raw materials are taken to add water extraction, filtering takes filtrate to be concentrated into relative density to be
1.35-1.45 medicinal extract, it is standby；
(2) preparation of acid particles：Take whole malic acid, the 45-55% of whole lactose hydroxypropyl cellulose quality, whole
The 45-55% of sodium chloride quality, the 45-55% of whole maltodextrins are well mixed, and the 45-55% of medicinal extract total amount are added, with water
For wetting agent, softwood is made, then using wet granulation, is dried under the conditions of 30-40 DEG C；
(3) preparation of alkali grain：Take whole saleratus, step (2) remaining maltodextrin, PVP, Steviosin and leaching
Cream, using water as wetting agent, is made softwood, then using wet granulation, is dried under the conditions of 30-40 DEG C.
Step (1), which is concretely comprised the following steps, takes above-mentioned raw materials plus 5-10 times of quality water to boil extraction 3-4h, and filtering takes residue to repeat
Extraction, is then filtered, and merges filtrate twice, is concentrated into the medicinal extract that relative density is 1.35-1.45.
The present invention is raw materials used and auxiliary material pharmacological properties are：
Sealwort：Also known as celestial being's surplus grain, sweet, slightly warm in nature, there is a good tonifying lung, hypoglycemic, boosting qi and nourishing yin, invigorating the spleen, moistening lung,
Kidney-nourishing, antifatigue, anti-oxidant, delaying human body caducity, the effect of strengthen immunity.
Radix polygonati officinalis：It is sweet, mild-natured.Return lung, stomach；Nourishing Yin and moistening lung, nourishing the stomach to improve the production of body fluid；Cough caused by dryness, chatters and coughs；Pyreticosis yin-fluid consumes the pharynx of wound
It is dry thirsty；Heat Diabetes；Deficiency of Yin diseases caused by external factors；Have a dizzy spell.
The Radix Astragali：With tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, blood-nourishing of promoting the production of body fluid, the stagnant logical numbness of row, effect of detoxification apocenosis；
The main active of the Radix Astragali has astragalus polyose, saponin(e and flavonoids, and it has anti-oxidant, antifatigue, strengthen immunity, disease-resistant
Malicious, antitumor, bidirectional modulation blood glucose and anti-aging etc. are acted on.
Donkey-hide gelatin：Excellent tonic product, enriching yin of enriching blood, moisturizes, hemostasis, for blood deficiency chlorosis, dizziness palpitaition, dysphoria and insomnia, the dryness of the lung
Cough.
Chinese yam：Can invigorating the spleen qi-restoratives, grow essence and reinforce the kidney, control all damages of Xu hundred, treat general debility, can yang-tonifying with strong internal organs work(
Can, and energy tonifying yin is with material base of supplementing nutrition.
Poria cocos：Clearing damp and promoting diuresis, strengthening the spleen and reducing phlegm, antitoxic heart-soothing and sedative, internal heat anticance, reduction blood glucose and hydrochloric acid in gastric juice.
Matrimony vine：With auxiliary reducing blood lipid, anti-oxidant, enriching yin and nourishing kidney support courage improving eyesight, alleviate physical fatigue, improve microcirculation,
The effects such as strengthen immunity.
Shaddock grunt：With beautifying face and moistering lotion, regulating qi-flowing for eliminating phlegm, moistening lung gut purge, eliminating phlegm is quenched the thirst, happy color of making light of one's life by commiting suicide, hypoglycemic, reducing blood lipid
Deng effect.
Jujube：Containing sugar, vitamin C, also containing abundant protein, fat, phosphorus, calcium, iron, potassium, sodium, magnesium, chlorine, iodine, Buddhist nun
Gram multivitamin such as acid and vitamin A, B1.The sweet and refreshing delicate fragrance of taste, and with higher nutritive value, it is considered as good
Invigorant, with invigorating heart moistening lung, closes spleen stomach invigorating, nourishing generate fluid, the function of blood-enriching face-nourishing.
White fungus：With tonifying spleen appetizing, QI invigorating gut purge, sleeping stomach invigorating, cerebrum tonifying, replenishing the vital essence and removing heat moisturizes, the effect of nti-freckle.
Asparagus：Containing substantial amounts of flavones, saponin(e and aspartic acid, lysine, for it is antifatigue, prevent hypertension, artery
The diseases such as hardening, heart disease, hepatitis, hepatic sclerosis, ephritis, oedema, cystitis, alleviate pressure, improve memory while also having
Function.
In above-mentioned raw materials and auxiliary material, using sealwort, radix polygonati officinalis as major ingredient, can invigorating the spleen, nourishing Yin and moistening lung it is antifatigue, donkey-hide gelatin, matrimony vine,
Jujube can strengthen the effect filled blood, and Chinese yam spleen-strengtheningporridge qi-restoratives is grown essence and reinforced the kidney, shaddock grunt moistening lung gut purge, white fungus tonifying spleen appetizing, asparagus
Strengthen anti-fatigue effect, the medicine of above-mentioned help eat it is more after can cause the addition Radix Astragali, Poria cocos in feeling of fullness gasteremphraxis, therefore formula
Can the sharp gas of dampness elimination, reduce adverse reaction, it is eaten for a long time.Donkey-hide gelatin, jujube, matrimony vine, shaddock grunt in raw material carry sweet tea
Taste, can neutralize the bad mouthfeel that other raw bands come.Meanwhile, the bubble synthesized using sodium acid carbonate as alkali source and by acid source of malic acid
Rise after particle is dissolved in water, produce substantial amounts of carbon dioxide, can play contain in obvious flavored action, Chinese yam water body liquid compared with
Many lymphatic temperaments, the easy moisture absorption caking of storage time length, experiment is found by adding filler lactose and hydroxypropyl cellulose, dividing
Powder maltodextrin can prevent from bonding, and cook disintegrant using sodium acid carbonate and malic acid, can be dissolved rapidly after adding water, without residual
Stay.
Compared with prior art, formula is simple, reasonable by the present invention, and taste is sweet, salubrious tasty, and product is conveniently stored and taken
Band, it is prevented from caking, it is instant fast, it is on probation by user, can rapid recovery fatigue in a short time, recover complexion, mitigate muscle
Ache, effect substantially, while also have nourishing yin to moisten dryness, promote the production of body fluid to quench thirst, yin-nourishing green blood, improve immunity, soothing nerves and assisting sleep sleep etc. work(
Effect.
Embodiment
Embodiment 1
A kind of polygonatum Solomon's seal effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：47-53 parts of sealwort, 97-103 parts of radix polygonati officinalis, 57-63 parts of the Radix Astragali, 27-33 parts of donkey-hide gelatin, 27-33 parts of Chinese yam, Fu
17-23 parts of Siberian cocklebur, 7-13 parts of shaddock grunt, 7-13 parts of jujube, 17-23 parts of matrimony vine, 12-18 parts of white fungus, 6-8 parts of asparagus；
Auxiliary material：40-50 parts of sodium acid carbonate, 40-50 parts of malic acid, 280-300 parts of lactose, 10-12 parts of hydroxypropyl cellulose,
8-12 parts of sodium chloride, 4-6 parts of maltodextrin.
The preparation method of above-mentioned polygonatum Solomon's seal effervescence granular, comprises the following steps：
(1) above-mentioned raw materials plus 5-10 times of quality water is taken to boil extraction 3-4h, filtering takes residue to repeat extraction, then filtered,
Merge filtrate twice, be concentrated into the medicinal extract that relative density is 1.35-1.45, it is standby；
(2) preparation of acid particles：Take whole malic acid, the 45-55% of whole lactose hydroxypropyl cellulose quality, whole
The 45-55% of sodium chloride quality, the 45-55% of whole maltodextrins are well mixed, and the 45-55% of medicinal extract total amount are added, with water
For wetting agent, softwood is made, then using wet granulation, is dried under the conditions of 30-40 DEG C；
(3) preparation of alkali grain：Take whole saleratus, step (2) remaining maltodextrin, PVP, Steviosin and leaching
Cream, using water as wetting agent, is made softwood, then using wet granulation, is dried under the conditions of 30-40 DEG C.
Embodiment 2
A kind of polygonatum Solomon's seal effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：50 parts of sealwort, 100 parts of radix polygonati officinalis, 60 parts of the Radix Astragali, 30 parts of donkey-hide gelatin, 30 parts of Chinese yam, 20 parts of Poria cocos, shaddock grunt 10
Part, 10 parts of jujube, 20 parts of matrimony vine, 15 parts of white fungus, 7 parts of asparagus；
Auxiliary material：45 parts of sodium acid carbonate, 45 parts of malic acid, 290 parts of lactose, 11 parts of hydroxypropyl cellulose, 10 parts of sodium chloride, wheat
5 parts of bud dextrin.
The preparation method of above-mentioned polygonatum Solomon's seal effervescence granular, comprises the following steps：
(1) above-mentioned raw materials plus 8 times of quality water are taken to boil extraction 3.5h, filtering takes residue to repeat extraction, then filtered, closes
And filtrate twice, the medicinal extract that relative density is 1.40 is concentrated into, it is standby；
(2) preparation of acid particles：Take whole malic acid, the 50% of whole lactose hydroxypropyl cellulose quality, whole chlorine
Change the 50% of sodium quality, the 50% of whole maltodextrins to be well mixed, add the 50% of medicinal extract total amount, using water as wetting agent, system
Into softwood, then using wet granulation, dried under the conditions of 35 DEG C；
(3) preparation of alkali grain：Take whole saleratus, step (2) remaining maltodextrin, PVP, Steviosin and leaching
Cream, using water as wetting agent, is made softwood, then using wet granulation, is dried under the conditions of 35 DEG C.
The polygonatum Solomon's seal effervescence granular taste obtained using said ratio and method is sweet, salubrious tasty, and product is convenient to be stored up
Deposit and carry, it is prevented from caking, it is instant fast, it is on probation by user, can rapid recovery fatigue in a short time, recover complexion, subtract
Light DOMS, effect substantially, while also have nourishing yin to moisten dryness, promote the production of body fluid to quench thirst, yin-nourishing green blood, improve immunity, soothing nerves and assisting sleep
The effects such as dormancy.
Embodiment 3
A kind of polygonatum Solomon's seal effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：49 parts of sealwort, 102 parts of radix polygonati officinalis, 58 parts of the Radix Astragali, 28 parts of donkey-hide gelatin, 30 parts of Chinese yam, 20 parts of Poria cocos, shaddock grunt 10
Part, 10 parts of jujube, 20 parts of matrimony vine, 15 parts of white fungus, 7 parts of asparagus；
Auxiliary material：42 parts of sodium acid carbonate, 48 parts of malic acid, 295 parts of lactose, 11 parts of hydroxypropyl cellulose, 10 parts of sodium chloride, wheat
5 parts of bud dextrin.
The polygonatum Solomon's seal effervescence granular taste obtained using said ratio and method is sweet, salubrious tasty, and product is convenient to be stored up
Deposit and carry, it is prevented from caking, it is instant fast, it is on probation by user, being capable of fatigue-relieving, recovery complexion, mitigation DOMS, effect
Substantially, at the same also have nourishing yin to moisten dryness, promote the production of body fluid to quench thirst, yin-nourishing green blood, improve immunity, the effects such as soothing nerves and assisting sleep is slept.
Comparative example 1
A kind of polygonatum Solomon's seal effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：50 parts of sealwort, 100 parts of radix polygonati officinalis, 60 parts of the Radix Astragali, 30 parts of donkey-hide gelatin, 30 parts of Chinese yam, 20 parts of Poria cocos, shaddock grunt 10
Part, 10 parts of jujube, 20 parts of matrimony vine, 15 parts of white fungus, 7 parts of asparagus；
Auxiliary material：45 parts of sodium carbonate, 45 parts of malic acid, 290 parts of lactose, 11 parts of hydroxypropyl cellulose, 10 parts of sodium chloride, malt
5 parts of dextrin.
Preparation method be the same as Example 2.This example compared with Example 2, sodium acid carbonate is changed and replaces with sodium carbonate, by pre- reality
Issue after examination and approval now, although the polygonatum Solomon's seal effervescence granular obtained using said ratio and method is with antifatigue effect, dissolving
Speed is slower.
Comparative example 2
A kind of polygonatum Solomon's seal effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：50 parts of sealwort, 100 parts of radix polygonati officinalis, 60 parts of the Radix Astragali, 30 parts of donkey-hide gelatin, 30 parts of Chinese yam, 20 parts of Poria cocos, shaddock grunt 10
Part, 10 parts of jujube, 20 parts of matrimony vine, 15 parts of white fungus, 7 parts of asparagus；
Auxiliary material：45 parts of sodium acid carbonate, 45 parts of tartaric acid, 290 parts of lactose, 11 parts of hydroxypropyl cellulose, 10 parts of sodium chloride, wheat
5 parts of bud dextrin.
Preparation method be the same as Example 2.Malic acid compared with Example 2, is replaced with tartaric acid by this example, is sent out by preliminary experiment
It is existing, although the polygonatum Solomon's seal effervescence granular obtained using said ratio and method is with antifatigue effect, easy deliquescence knot
Block, dissolution velocity is slow.
Comparative example 3
A kind of polygonatum Solomon's seal effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：50 parts of sealwort, 100 parts of radix polygonati officinalis, 60 parts of the Radix Astragali, 30 parts of donkey-hide gelatin, 30 parts of Chinese yam, 20 parts of Poria cocos, shaddock grunt 10
Part, 10 parts of jujube, 20 parts of matrimony vine, 15 parts of white fungus, 7 parts of asparagus；
Auxiliary material：45 parts of sodium acid carbonate, 45 parts of malic acid, PVP290 parts, 11 parts of hydroxypropyl cellulose, 10 parts of sodium chloride, wheat
5 parts of bud dextrin.
Preparation method be the same as Example 2.Lactose compared with Example 2, is replaced with PVP by this example, is found by preliminary experiment, is adopted
Although the polygonatum Solomon's seal effervescence granular obtained with said ratio and method is with antifatigue effect, easy deliquescence caking.
Comparative example 4
A kind of polygonatum Solomon's seal effervescence granular, it is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：50 parts of sealwort, 100 parts of radix polygonati officinalis, 60 parts of the Radix Astragali, 30 parts of donkey-hide gelatin, 30 parts of Chinese yam, 20 parts of Poria cocos, shaddock grunt 10
Part, 10 parts of jujube, 20 parts of matrimony vine, 15 parts of white fungus, 7 parts of asparagus；
Auxiliary material：45 parts of sodium acid carbonate, 45 parts of malic acid, 290 parts of lactose, 11 parts of hydroxypropyl cellulose, 10 parts of sodium acetate, wheat
5 parts of bud dextrin.
Preparation method be the same as Example 2.Sodium chloride compared with Example 2, is replaced with sodium acetate by this example, is sent out by preliminary experiment
It is existing, although the polygonatum Solomon's seal effervescence granular obtained using said ratio and method is with antifatigue effect, dissolution velocity
And dissolving is incomplete slowly,.
Dissolve comparative test：
The polygonatum Solomon's seal effervescence granular (No. 1 group) that is obtained respectively to the proportioning according to embodiment 2, according to comparative example 1
The obtained polygonatum Solomon's seal effervescence granular (No. 2 groups) of proportioning, the polygonatum Solomon's seal effervescence granular obtained according to the proportioning of comparative example 2
(No. 3 groups), the polygonatum Solomon's seal effervescence granular obtained according to the proportioning of comparative example 3 (No. 4 groups), the proportioning institute according to comparative example 4
The water that the polygonatum Solomon's seal effervescence granular (No. 5 groups) of acquisition adds equivalent is dissolved, and is whether there is before five groups of effervescence granular dissolvings of observation
Whether particle has residual after caking and dissolving, and records the dissolving time limit.
Result of the test such as table 1：
Table 1
Power exhausts control experiment
Test method：Divide six groups, every group of 10 mouse, using administration by gavage, daily with 0.6g/kg dosages to every by mouse
Group mouse gavages the drink (No. 1 group) after antifatigue effervescence granular is instant on the market, obtained according to the proportioning of embodiment 2 respectively
Polygonatum Solomon's seal effervescence granular it is instant after drink (No. 2 groups) control group give equivalent distilled water.1 time/d, continuous 21d.
Motion model control group starts to carry out mouse adaptability swimming instruction with experimental group 15d after to mouse stomach
Practice, swimming time is incremented by 5min to the 20th days, the standard that power exhausts judgement is born a heavy burden by mouse weight 5% daily by 15min/d
Swimming does not float to the mouse 10s that sinks under water, and righting reflex can not be carried out after pulling out.Swimming time：Last is filled to mouse
Take after 30min, use load mode in lead of the mass of rat-tail bar system one for mouse weight 5%, mouse is placed in 33cm trip
In swimming case, by the temperature control in swimming trunk at 28 DEG C or so.Force mouse to swim to power to exhaust, namely the 10s that sinks under water is not floated
Rise, record the swimming time of mouse.
The swimming time of table 2
| Group | Average time min |
| Control group | 8.5±0.6 |
| 1 group of experimental group | 12.5±2.7* |
| 2 groups of experimental group | 14.3±1.9** |
Note：Compared with control group*P ＜ 0.05,**P ＜ 0.01；
Note：Above-mentioned experiment is on the basis of multiple screening test, for the checking test of technical solution of the present invention.
Experiment conclusion：Above-mentioned result of the test shows, the formula for the polygonatum Solomon's seal effervescence granular that the embodiment of the present invention 2 is provided
(experimental group 2) mice burden swimming time is most long, illustrates the antifatigue effect of polygonatum Solomon's seal effervescence granular that the embodiment of the present invention 2 is provided
It is really best.
The formula that the polygonatum Solomon's seal effervescence granular of 4-24 of embodiment of the present invention offers is raw materials used is shown in Table 3-5, auxiliary material used
Formula be shown in Table 6-8, the other the same as in Example 2.
Table 3
| Raw material | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 |
| Sealwort | 52 | 51 | 53 | 47 | 49 | 48 | 50 |
| Radix polygonati officinalis | 100 | 97 | 100 | 98 | 101 | 99 | 102 |
| The Radix Astragali | 59 | 61 | 60 | 63 | 61 | 60 | 57 |
| Donkey-hide gelatin | 30 | 28 | 27 | 31 | 28 | 32 | 29 |
| Chinese yam | 28 | 32 | 29 | 33 | 30 | 30 | 27 |
| Poria cocos | 20 | 22 | 17 | 23 | 18 | 17 | 22 |
| Shaddock grunt | 9 | 13 | 10 | 11 | 10 | 7 | 12 |
| Jujube | 10 | 8 | 7 | 11 | 8 | 12 | 9 |
| The fruit of Chinese wolfberry | 21 | 17 | 22 | 18 | 23 | 19 | 17 |
| White fungus | 16 | 12 | 13 | 17 | 14 | 18 | 15 |
| Asparagus powder | 8 | 7 | 6.5 | 7.5 | 6 | 7 | 8 |
Table 4
| Raw material | Embodiment 11 | Embodiment 12 | Embodiment 13 | Embodiment 14 | Embodiment 15 | Embodiment 16 | Embodiment 17 |
| Sealwort | 49 | 48 | 50 | 47 | 51 | 53 | 52 |
| Radix polygonati officinalis | 100 | 103 | 101 | 97 | 102 | 98 | 103 |
| The Radix Astragali | 62 | 59 | 63 | 60 | 57 | 61 | 58 |
| Donkey-hide gelatin | 33 | 30 | 27 | 31 | 29 | 32 | 30 |
| Chinese yam | 31 | 28 | 32 | 29 | 33 | 30 | 27 |
| Poria cocos | 20 | 23 | 17 | 21 | 17 | 18 | 18 |
| Shaddock grunt | 8 | 13 | 9 | 7 | 10 | 8 | 11 |
| Jujube | 13 | 10 | 7 | 11 | 9 | 12 | 10 |
| The fruit of Chinese wolfberry | 20 | 18 | 21 | 19 | 22 | 20 | 23 |
| White fungus | 12 | 16 | 13 | 17 | 14 | 18 | 15 |
| Asparagus powder | 6.5 | 7.5 | 6 | 7 | 8 | 6.5 | 7.5 |
Table 5
| Raw material | Embodiment 18 | Embodiment 19 | Embodiment 20 | Embodiment 21 | Embodiment 22 | Embodiment 23 | Embodiment 24 |
| Sealwort | 47 | 53 | 52 | 47 | 51 | 48 | 50 |
| Radix polygonati officinalis | 99 | 97 | 103 | 98 | 102 | 99 | 101 |
| The Radix Astragali | 62 | 59 | 63 | 60 | 57 | 61 | 58 |
| Donkey-hide gelatin | 33 | 31 | 27 | 32 | 28 | 33 | 29 |
| Chinese yam | 31 | 28 | 32 | 29 | 33 | 30 | 27 |
| Poria cocos | 22 | 22 | 17 | 23 | 18 | 20 | 19 |
| Shaddock grunt | 9 | 12 | 10 | 13 | 11 | 7 | 12 |
| Jujube | 13 | 11 | 7 | 12 | 8 | 13 | 9 |
| The fruit of Chinese wolfberry | 21 | 17 | 22 | 18 | 20 | 19 | 23 |
| White fungus | 12 | 16 | 13 | 15 | 14 | 18 | 15 |
| Asparagus powder | 6 | 7 | 8 | 6.5 | 7 | 6 | 7.5 |
Table 6
| Raw material | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | Embodiment 9 | Embodiment 10 |
| Sodium acid carbonate | 44 | 45 | 46 | 44 | 48 | 46 | 40 |
| Malic acid | 40 | 46 | 50 | 40 | 45 | 42 | 40 |
| Lactose | 295 | 280 | 290 | 285 | 300 | 290 | 280 |
| Hydroxypropyl cellulose | 10.5 | 11.5 | 11 | 10 | 11.5 | 10.5 | 12 |
| Sodium chloride | 12 | 8 | 10 | 9 | 10 | 8 | 10 |
| Maltodextrin | 4 | 5.5 | 4.5 | 4 | 5 | 4.5 | 5.5 |
Table 7
| Raw material | Embodiment 11 | Embodiment 12 | Embodiment 13 | Embodiment 14 | Embodiment 15 | Embodiment 16 | Embodiment 17 |
| Sodium acid carbonate | 50 | 42 | 48 | 44 | 46 | 46 | 44 |
| Malic acid | 44 | 42 | 46 | 44 | 48 | 46 | 50 |
| Lactose | 295 | 285 | 300 | 285 | 280 | 290 | 285 |
| Hydroxypropyl cellulose | 11 | 10 | 11.5 | 10.5 | 12 | 10 | 11 |
| Sodium chloride | 9 | 11 | 10 | 12 | 11 | 8 | 12 |
| Maltodextrin | 5 | 6 | 5.5 | 4 | 6 | 4.5 | 4 |
Table 8
| Raw material | Embodiment 18 | Embodiment 19 | Embodiment 20 | Embodiment 21 | Embodiment 22 | Embodiment 23 | Embodiment 24 |
| Sodium acid carbonate | 48 | 42 | 50 | 40 | 45 | 42 | 40 |
| Malic acid | 48 | 42 | 45 | 44 | 48 | 46 | 50 |
| Lactose | 300 | 290 | 280 | 295 | 285 | 300 | 290 |
| Hydroxypropyl cellulose | 10.5 | 11.5 | 11 | 12 | 11.5 | 10.5 | 12 |
| Sodium chloride | 8 | 10 | 9 | 11 | 10 | 9 | 11 |
| Maltodextrin | 5 | 4.5 | 5.5 | 5 | 6 | 5.5 | 4.5 |
Claims (4)
1. a kind of polygonatum Solomon's seal effervescence granular, it is characterised in that：It is prepared from by the raw material and auxiliary material of following parts by weight：
Raw material：47-53 parts of sealwort, 97-103 parts of radix polygonati officinalis, 57-63 parts of the Radix Astragali, 27-33 parts of donkey-hide gelatin, 27-33 parts of Chinese yam, Poria cocos 17-
23 parts, 7-13 parts of shaddock grunt, 7-13 parts of jujube, 17-23 parts of matrimony vine, 12-18 parts of white fungus, 6-8 parts of asparagus；
Auxiliary material：40-50 parts of sodium acid carbonate, 40-50 parts of malic acid, 280-300 parts of lactose, 10-12 parts of hydroxypropyl cellulose, chlorination
8-12 parts of sodium, 4-6 parts of maltodextrin.
2. polygonatum Solomon's seal effervescence granular as claimed in claim 1, it is characterised in that：It is by the raw material of following parts by weight and auxiliary
Material is prepared from：
Raw material：It is 50 parts of sealwort, 100 parts of radix polygonati officinalis, 60 parts of the Radix Astragali, 30 parts of donkey-hide gelatin, 30 parts of Chinese yam, 20 parts of Poria cocos, 10 parts of shaddock grunt, big
10 parts of jujube, 20 parts of matrimony vine, 15 parts of white fungus, 7 parts of asparagus；
Auxiliary material：45 parts of sodium acid carbonate, 45 parts of malic acid, 290 parts of lactose, 11 parts of hydroxypropyl cellulose, 10 parts of sodium chloride, malt paste
5 parts of essence.
3. the preparation method of the polygonatum Solomon's seal effervescence granular as described in claim any one of 1-2, it is characterised in that including following
Step：
（1）It is prepared by raw material extraction stiff paste：Above-mentioned raw materials are taken to add water extraction, filtering takes filtrate to be concentrated into relative density for 1.35-
1.45 medicinal extract, it is standby；
（2）The preparation of acid particles：Take whole malic acid, the 45-55% of whole lactose hydroxypropyl cellulose quality, whole chlorinations
The 45-55% of sodium quality, the 45-55% of whole maltodextrins are well mixed, and add the 45-55% of medicinal extract total amount, using water as wetting
Agent, is made softwood, then using wet granulation, is dried under the conditions of 30-40 DEG C；
（3）The preparation of alkali grain：Take whole saleratus, step（2）Remaining maltodextrin, PVP, Steviosin and medicinal extract,
Using water as wetting agent, softwood is made, then using wet granulation, is dried under the conditions of 30-40 DEG C.
4. the preparation method of polygonatum Solomon's seal effervescence granular as claimed in claim 3, it is characterised in that step（1）Concretely comprise the following steps
Above-mentioned raw materials plus 5-10 times of quality water is taken to boil extraction 3-4h, filtering takes residue to repeat extraction, then filtered, and merging is filtered twice
Liquid, is concentrated into the medicinal extract that relative density is 1.35-1.45.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109221867A (en) * | 2018-10-08 | 2019-01-18 | 康学春 | A kind of rhizoma polygonati corn stigma Radix Astragali solid beverage and preparation method thereof |
| CN111150053A (en) * | 2019-10-31 | 2020-05-15 | 成都青衣美人科技有限公司 | Freeze-dried polygonatum sibiricum, polygonatum odoratum and tremella soup and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102293292A (en) * | 2011-07-03 | 2011-12-28 | 乌苏市盛维生物工程有限公司 | Health tea with functions of yin nourishing and blood nourishing, and processing method thereof |
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| CN102293292A (en) * | 2011-07-03 | 2011-12-28 | 乌苏市盛维生物工程有限公司 | Health tea with functions of yin nourishing and blood nourishing, and processing method thereof |
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| CN109221867A (en) * | 2018-10-08 | 2019-01-18 | 康学春 | A kind of rhizoma polygonati corn stigma Radix Astragali solid beverage and preparation method thereof |
| CN111150053A (en) * | 2019-10-31 | 2020-05-15 | 成都青衣美人科技有限公司 | Freeze-dried polygonatum sibiricum, polygonatum odoratum and tremella soup and preparation method thereof |
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