CN104739977A - Maca health wine/tablet with function of strengthening primordial qi - Google Patents

Abstract

The invention provides a maca health wine/tablet with a function of strengthening primordial qi, and belongs to high-grade healthcare wine. The maca health wine/tablet is particularly prepared from Tibet plateau natural non-pollution high-quality medicine-food dual-purpose wild plant all-grass of Chinese brake, wild fleckedflesh polypore, wild root of silverweed cinquefoil, hemarthria altissima, maca, root of setose abelmoschus, sea cucumber, earthworm, puncturevine caltrop fruit, common macrocarpium fruit, fennel fruit, hawthorn fruit, highland barley wine and the like. The maca health wine/tablet has the effects of nourishing the kidney and strengthening the essence, reinforcing qi and nourishing blood, nourishing liver and improving eyesight, strengthening the spleen and stomach and the like, and also has the functions of preventing fatigue, enhancing sexual function, preventing erectile dysfunction, treating diseases of prostate, improving immunity, resisting oxidation and aging, prolonging life and resisting tumors. A manufacturing process of the maca health wine/tablet comprises the steps of mixing and crushing raw materials, performing twice water leaching and extracting, performing once highland barley wine (60 degrees) leaching and extracting, mixing water extract and wine extract, stirring, precipitating, filtering, filling, covering, detecting and packing.

Description

Lepidinm meyenii Walp health preserving tonic wine (sheet)

One, technical field: the invention belongs to high-end health-care white spirit or sheet, especially with raw materials such as the natural pollution-free high-quality medicine-food two-purpose wild plant Lycium ruthenicum Murr. in Qinghai-Tibet Platean, wild yellow mushroom, wild Radix potentillae anserinae, penis et testis bovis of Bos grunniens grass, Lepidinm meyenii Walp, Abelmoschus esculentus, Stichopus japonicus, Pheretima, Fructus Tribuli, Fructus Corni, Fructus Foeniculi, Fructus Crataegi, barley wines, the health promoting wine that modern advanced technologies processes is adopted.

Two, background technology: the health promoting wine that the present invention makes for raw material with wild Lycium ruthenicum Murr., wild yellow mushroom, wild Radix potentillae anserinae, Lepidinm meyenii Walp, Abelmoschus esculentus, penis et testis bovis of Bos grunniens grass, Stichopus japonicus, Pheretima, Fructus Tribuli, Fructus Corni, Fructus Foeniculi, Fructus Crataegi, barley wine.This product has the effects such as the kidney invigorating and essence nourishing, benefiting QI and nourishing blood, nourishing liver for improving eyesight, invigorating the spleen and regulating the stomach.Be adapted to resisting fatigue, sexual function improving, prevent and treat sexual impotence, the effect such as prostatosis, raising immunity, antioxidation, defying age, life lengthening, antitumor.Also this product does not occur in the market, and this product of innovation research and development can be and provides a kind of high-end new product to middle-aged and elderly people.This product is natural quality medicine food dual purpose plant, purity is high, good absorbing, biological activity are strong, without any side effects, good taste, mouthfeel are soft, Be very effective, is the superior good merchantable brand of drinks.

Three, summary of the invention: along with the fast development of China's economy, national income and living standard improve constantly, and the expection of human longevity extends, and the health care consciousness of people strengthens day by day, especially more strong with good health and a long life to quality of life.

Four, composition of raw materials: wild Lycium ruthenicum Murr. 5-10 kilogram, wild yellow mushroom 12-22 kilogram, wild Radix potentillae anserinae 10-20 kilogram, penis et testis bovis of Bos grunniens grass 10-15 kilogram, Lepidinm meyenii Walp 15-20 kilogram, Abelmoschus esculentus 7-16 kilogram, Stichopus japonicus 6-12 kilogram, Pheretima 8-16 kilogram, Fructus Tribuli 9-18 kilogram, Fructus Corni 10-15 kilogram, Fructus Foeniculi 1-6 kilogram, Fructus Crataegi 11-20 kilogram, barley wine 1000L be raw material.

Five, technical scheme:

(1), Lycium ruthenicum Murr.: (Lyciam barbarnm extraat), Lycium ruthenicum Murr. grows at Qinghai-Tibet green ecological environment, pure natural treasure medicine food dual purpose plant Lycium ruthenicum Murr. dry fruit.Lycium ruthenicum Murr. is a kind of high-end tonic of ecosystem of rare preciousness.Lycium ruthenicum Murr. is matrimony vine of solanaceae plant mature fruit.Property is put down, sweet in the mouth.Return liver, kidney channel.There is effect of nourishing the liver and kidney, replenishing vital essence to improve eyesight, lung moistening.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, raising vision, blurred vision are not clear.Modern medicine study is thought, Lycium ruthenicum Murr. has enhancing immunity, resisting fatigue, blood pressure lowering, blood fat reducing, blood sugar lowering, the liver protecting, beauty treatment and eliminating spot, fat-reducing, defying age, the function such as anticancer.

Chemical composition: Lycium ruthenicum Murr. is containing trace element such as multivitamin and manganese, chromium, zinc, copper, magnesium, calcium, germanium, cobalt such as polysaccharide, aminoacid, betanin, carotene, vitamin B, vitamin C, nicotinic acid.And also have abundant natural procyanidins, wherein procyanidin content is the several times of blue berry content, is the wild plant finding that procyanidin content is the highest up to now.

Pharmacological action: 1, enhancing immunity: mouse gavaging water extract or intramuscular injection alcohol extract all significantly can strengthen the phagocytic activity of its reticuloendothelial system to india ink.Water extract or lycium barbarum polysaccharide all can promote lysozyme activity in Phagocytosis By The Peritoneal Macrophages In Mice and serum.Give normal or Aged Mice gavages or abdomen note lycium barbarum polysaccharide, can significantly strengthen peritoneal macrophage c ₃the acceptor number of b and Fc and vigor, can make Aged Mice suppressor T lymphocyte regulate antibody function to return to the level of adult mice.Lycium ruthenicum Murr. polysaccharide sterling has more significant effect of immune response than crude product, every immune indexes (comprise the serum hemolysin of the immune organ quality of nonspecific immunity, macrophage phagocytic effect, specific humoral immunity, moving back hair style allergy, lymhocyte transformation rate, E red rose pigment etc. in specific cellular immunity) all has significant difference.

2, the liver protecting, anti-fatty liver: Lycium ruthenicum Murr. extract has certain effect to the liver protecting and anti-fatty liver tool.Modern medicine study finds, containing a kind of effective ingredient-betanin in Lycium ruthenicum Murr., it is very effective to treatment hepatic disease.Experiment shows, betanin has suppression fat to deposit in hepatocyte, promotes the effect of liver cell regeneration.In addition, the middle betanin of Lycium ruthenicum Murr. can prevent excess fat storage in liver, has the effect of anti-fatty liver, it is reported, feeds water extract or betanin feedstuff to ccl for a long time through rat ₄the hepatic injury caused has protective effect, obviously can reduce the change of lipid in transaminase and liver, can suppress lipidosis and promotion hepatocyte new life in liver, have significant protective effect to hepatic lipid peroxidation damage.

3, promote hemopoietic, Lycium ruthenicum Murr. extract can make burst forming unit erythroid（BFU E） and colony-forming unit-erythroid in normal mouse bone marrow rise; Mouse spleen T lymphocytic emiocytosis colony stimulating factor can be promoted, improve mouse colony stimulating activity level; In cultivating in vitro and being not, Lycium ruthenicum Murr. extract can strengthen the colony stimulating activity of colony stimulating factor.Also can promote the propagation of Bone Marrow Hematopoietic Stem Cells of Mice, obviously increase bone marrow monosystem cell quantity, promote that CFU-GM breaks up to grain system.

4, antiinflammatory antiallergic: histamine can cause skin allergy and redness, procyanidin is a kind of natural antihistaminic, has excellent antiphlogistic effects, can prevent the effect of inflammation after skin allergy and Exposure to Sunlight.

5, delay reproductive system aging: according to domestic, an achievement in research shows, Lycium ruthenicum Murr., can to the reproductive system generation effect be damaged by effect " hypothalamic-pituitary-gonadal " axis.Experimental result shows, Lycium ruthenicum Murr. promotes pituitary sex gland hormones by gonadotropin effect, to " hypothalamic-pituitary-gonadal " axis, produces multilamellar regulating action.Promote that During spermatogenesis is unimpeded to grow with Testicular Germ Cell.

6, improvement function: Lycium ruthenicum Murr. has invigorating the liver and kidney, promoting generation of vital essence and blood, supporing yang function, be that insufficiency of kidney-YANG or deficiency of the kidney yin all have certain effect, Lycium ruthenicum Murr. extract also has the effect of short gonad function, and blood testis cave level significantly raises, to sexual hypofunction, sexual impotence has important effect.

(2) Radix potentillae anserinae (Potentilla anserinal), has another name called Herba Herminii, life-prolonging time grass.For the tuber of Qinghai-Tibet Rosaceae Potentilla wild plant, being called " tall and erect Lao Sha monk " in Tibetan language, is that finish doctor commonly uses medical herbs.Cool in nature, sweet in the mouth.There is the effects such as benefiting vital QI and blood, strengthening the spleen and nourishing the stomach, promoting the production of body fluid to quench thirst.Be applicable to nourishing kidney-yin, after being ill anemia, malnutrition, insufficiency of the spleen diarrhoea, cough-relieving profit expectorant, haematemesis, dysentery etc.Modern pharmacological research shows, Radix potentillae anserinae has myocardium, the antibacterial and fatigue-resisting function of enhancing immunity, antioxidation, defying age, antiinflammatory, protection, has higher medical treatment and nutritive value.

Chemical composition: starch-containing, protein, 18 seed amino acids (wherein containing 8 seed amino acids of needed by human), fatty acid, choline, betanin, polysaccharide, flavone compound, organic acid, dietary fiber, multivitamin and mineral matter and other components.

Pharmacological action: 1, antioxidation: research shows, potentilla anserina extract can improve damage mice serum superoxide dismutase vigor, reduces MDA level, alleviates free radical and piles up the membrane lipid peroxidatio damage caused.Therefore, Radix potentillae anserinae has very strong antioxidation, and this effect is relevant with the effect of its free radical resisting.

2, enhancing immunity: research shows that Radix potentillae anserinae has good protective effect to biological organs and cell.Research display, Radix potentillae anserinae water and ethanol extract have the effect that remarkable antioxidation cortisone induced mice thymic weight reduces, to the phagocytic function of immunity function low mice reticuloendothelial cell, there is obvious activation, simultaneously also can anti-caused by cyclophosphamide delayed hypersensitivity suppress, show that Radix potentillae anserinae has potentiation to the nonspecific immunity of body and cellular immune function.

3, enrich blood: Radix potentillae anserinae is obvious as its blood tonification effect of traditional Tibetan medicine.Modern pharmacological research confirms, Radix potentillae anserinae can improve the erythrocyte number in mouse blood, improves content of hemoglobin, has good blood tonification effect.Its mechanism of action may be promote marrow hemopoietic stem cells reproduction speed, and then promotes erythroneocytosis synthetic hemoglobin.

4, defying age: Radix potentillae anserinae anti-aging effects is realized by antioxidation and effect of scavenging radical.Free radical can cause protein oxidation, the multiple damage such as DNA mutation, lipid oxidation, and by regulating cell death inducing, the apoptosis process that Radix potentillae anserinae can suppress ROS to induce, so have significant anti-aging effects.

5, temper deficient syndrome is prevented and treated: research confirms, Radix potentillae anserinae has preventive and therapeutic effect to temper deficient syndrome.Result shows, Radix potentillae anserinae has facilitation to mouse cell immunity, has good protective effect to the atrophy of temper deficient syndrome mouse immune organ spleen.

(3), Lepidinm meyenii Walp (Maca), be Cruciferae Lepidium plateau herbaceous plant dry root.Be a kind of plateau plant growing mountain area, Peru Andean height above sea level 3500-4000 rice in South America, be rich in multiple natural nutrient substance, be indispensable nutrient substance during Peruvian lives, be called as Andean Radix Ginseng.China in 2002 Ministry of Public Health official approval enters China.In recent years, start in Qinghai-Tibet height above sea level more than 3000 meters region successful introduction, cultivated area expands year by year.Lepidinm meyenii Walp the kidney invigorating gas, YIN nourishing and YANG strengthening, replenishing essence of enriching blood.Research finds; Lepidinm meyenii Walp is rich in high unit nutrient; there is strengthening by means of tonics effect to human body, organism metabolism, renitency, resisting fatigue can be promoted, raising energy, strengthen men and women sexual function, improve fertility and galactopoiesis; and menoxenia, infertility, protection ovary can be prevented and treated, improve climacteric syndrome, breast enlargement, spot-eliminating beauty treatment, improving water flood, slow down aging; strengthen brain vigor; and strengthen fast the characteristic of physical ability, the effect such as anticancer, well received in the international market

Chemical analysis: Lepidinm meyenii Walp contains protein, fatty acid, aminoacid, saccharide, plant polyphenol, alkaloid, sterol, saponin, several mineral materials and Lepidinm meyenii Walp alkene and the composition such as macamide, glucosinolate.

Pharmacological action: 1, improve men and women's sexual function: the sixties that acts on that Lepidinm meyenii Walp can improve men and women's sexual function is just found, and zoopery shows, by being fed mice with Lepidinm meyenii Walp, finds that the ability of catching of flutterring of mice improves.People is had to carry out separation and Extraction to Lepidinm meyenii Walp subsequently, research finds, the Lepidinm meyenii Walp alkene that Lepidinm meyenii Walp contains and macamide, the materials such as sterol, find that the sexual function of female mice is significantly improved after feeding mice, male Mus erectile ability also improves a lot, experiment is inferred, the material strengthening male and female Mus sexual function is Lepidinm meyenii Walp alkene and macamide, and glucosinolate and isothiocyanic acid joint ester also improvement function is had a certain impact, and the report recently studied proves further, Lepidinm meyenii Walp is the sexuality that all can improve female, male mice in short-term or long-term nursing mice.According to another report, Lepidinm meyenii Walp is hormonal electromotor, can raising property neural excitation degree rapidly, makes that the hyperemia of spongy body, cell is expanded, hypersexuality, and increase sperm and vigor, alleviate depression and anxiety, regain one's strength of body.

2, fertility is improved: according to external, Lepidinm meyenii Walp can improve the fertility of mammal and Fish.As added the Lepidinm meyenii Walp of 6-10% in the feedstuff of guinea pig, find that the rate of teeming improves 36-45%, piglet birth weight improves 40-73%.It may be improve the quantity of the quantity of animal mature follicle corpusculum, sperm mobility and sperm that Lepidinm meyenii Walp improves its mechanism of effect of fertility, and therefore, the compositions such as the alkaloid contained in Lepidinm meyenii Walp, arginine and fructose are relevant.Alkaloid in Lepidinm meyenii Walp can the reproductive system of stimulating animal, feeding mice with alkaloid can make the follicle corpusculum of female adult be multiplied, the quantity that male Mus sperm produces increases, and arginine also has obvious effect to raising fertility, because arginine is the Main Ingredients and Appearance of sperm, and the mobility of sperm can be improved, the fructose in Lepidinm meyenii Walp can provide energy to play a role for sperm.

3, resisting fatigue: the administration of Lepidinm meyenii Walp different approaches, all can strengthen the mobility of necton under different water temperature, prolongation swimming time, has antifatigue effect, also can obvious prolong rats weight loading pressure swimming time.

(4) Abelmoschus esculentus, belongs to Malvaceae plant Abelmoschus esculentus annual herb plant, has very high nutritive value and medical function.Research shows, Abelmoschus esculentus has kidney tonifying tonify deficiency, sexual function improving, prevents and treats sexual impotence, resisting fatigue, regains one's strength, endocrine regulation, prevention and cure of cardiovascular disease, chronic gastritis, reduction cholesterol, looks improving and the skin nourishing, defying age, toxin expelling, fat-reducing, the effect such as prophylaxis of cancer and myopia.

Chemical composition: containing rich in protein, free amino acid, flavone, VitAVitE, vitamin C, carotene, vitamin B group, Yi Jitie, calcium, zinc, potassium, phosphorus and trace element, also containing the stickiness liquid material formed with the material such as pectin and polysaccharide.

Pharmacological action: 1, sexual function improving: the stickiness liquid material that Abelmoschus esculentus contains is called LM compound (a kind of material of similar natural hormone) by scientist, this material is made up of water-soluble fibre pectin, galactan and Radix Acaciae senegalis etc., these stickies mass-energy effective stimuluss male nervus centralis, accelerate blood circulation and the circulation of tip capillary blood, especially male genitals's blood circulation, improves sexual function.In addition, Abelmoschus esculentus also has preventive and therapeutic effect to prostatitis.

2, resisting fatigue, anoxia enduring: Radix Ginseng and Abelmoschus esculentus anti-fatigue effect contrast experiment, comprises endurance and anoxia enduring experiment, the impact of blood lactase acid level after resist cold heat-resisting and strenuous exercise.Experimental result shows, and Abelmoschus esculentus is similar with Radix Ginseng Endurence, and many one times of anoxia enduring Abelmoschus esculentus amount ratio Radix Ginseng, effect be same, show that Abelmoschus esculentus has significant resisting fatigue and resisting oxygen lack.

(5) Stichopus japonicus (Sea eueumber) is the entirety of Stichopodidae animal Stichopus japonicus.Warm in nature, sweet in the mouth, salty.There is effect of kidney-tonifying sperm-generating, blood enriching and dryness moistening, nourishing the five internal organs.Cure mainly deficiency of the kidney, impotence and seminal emission, frequency of micturition, the general power of the soreness of waist, cloudy anemia damage, emaciated physique, hectic fever coughed, spit blood, quench one's thirst, constipation etc.Modern medicine research shows, enhancing immunity, looks improving and the skin nourishing, resisting fatigue, enhancing development, slow down aging, blood pressure lowering, blood fat reducing, prevent and treat anemia, diabetes, postoperative health are recovered, the effect such as anticancer.

Chemical composition: containing Stichopus japonicus mucopolysaccharide, collagen protein, selenka, holothurin, glucosamine, the compositions such as protein, multivitamin and trace element.

Pharmacological action: 1, flaccidity is treated in the kidney invigorating: research shows, Stichopus japonicus has the effect of good the kidney invigorating, tonifying YANG, treatment flaccidity.Ancient medical book " saying age " is said: " Stichopus japonicus likeness in form man sun, can the kidney invigorating Xing Yang ", and " Bencao Congxin " adds Stichopus japonicus " Gan Xianwen, the kidney invigorating and essence nourishing, tonifying YANG treat flaccidity ", and " occupying diet spectrum with breath " Stichopus japonicus " nourishing YIN and supplementing blood, strong sun are moisturized ".Effect of cloudy, the invigorating kidney-YANG of " cause sexual impotence, premature ejaculation very important reason to be due to Liver and kidney YIN-fluid being insufficient, kidney yang declines and causes, and the effect that flaccidity is controlled in Stichopus japonicus tonifying YANG is it " liver and kidney tonifying is thought from Chinese medicine.The zinc, acidic polysaccharose, the holothurin isoreactivity composition that contain of Stichopus japonicus according to another report, has the effect improving erection function.

2, enhancing immunity: Stichopus japonicus mucopolysaccharide lumbar injection is to normal mouse, the mice of the immunocompromised that lotus tumor (MA-73) mice and cyclophosphamide cause all can make its Cellular immunity suppression recovering state, and phagocytic function and delayed hypersensitive reaction (DHR) improve.The weight of immune organ spleen, thymus can be strengthened to Mouse oral holothurian oral liquid preparation, and the activity of mouse red blood cell superoxide dismutase (SOD) can be improved.

3, resisting fatigue, anoxia enduring: Stichopus japonicus decoct can significantly improve the heat-resisting ability of mice to mouse stomach, increases the swimming time of mice, improves the time-to-live of mice under sealing anaerobic condition.

4, ability of learning and memory is improved: train mouse stomach with sea cucumber extract to through diving tower, then lumbar injection hyoscyamine 6mg/kg, cause memory deficits in mice, result of study finds, mouse wrong occurs obviously to extend incubation period, errors number also obviously reduces, and therefore, Stichopus japonicus tool increases significantly the effect of learning memory.

5, tonify deficiency, postoperative rehabilitation effect: Stichopus japonicus has strengthening the body resistance, improve the effect of immunologic function, build up resistance, patient is at sick, that intra-operative consumption is a large amount of nutrient substance, and now body requirement supplements the nutritional labeling of various urgent need.And Stichopus japonicus contains the nutritional labelings such as abundant arginine, arginine is the important source material of synthesized human collagen protein, has specially good effect to the reparation after body injury.Have experiment to prove, eat appropriate Stichopus japonicus every day, patient can be made to shift to an earlier date comprehensive rehabilitation in about 20 days, and therefore, postoperative patient, puerpera, fracture traumatic patient beche-de-mer can stop blooding, enrich blood, rebuild one's physical constitution, and obviously can shorten rehabilitation duration.

6, defying age: holothurian oral liquid obviously can extend the life-span of fruit bat, has anti-aging effects.In addition, Stichopus japonicus also has the effects such as anticoagulant, antiviral, radioprotective, analgesia, antifungal, antitumor, reduction cholesterol, antioxidation, looks improving and the skin nourishing.

(6) Pheretima (Pheretima), has another name called Lumbricus.For the dry body of Ju Yin section animal Pheretima aspergillum, popular Pheretimatschiliensis etc.Cold in nature, salty in the mouth.Return liver, spleen, urinary bladder channel.Have invigorating the spleen and replenishing QI, support kidney spermatogenesis, body weakness, Deficiency and coldness of spleen and stomach, night sweat due to weak body physique, heat clearing away is relieving convulsion, dredging collateral, relieving asthma, effect of diuresis.For sexual impotence, unconsciousness due to high fever, arthralgia, numb limbs and tense tendons, hemiplegia, lung-heat cough with asthma, oliguria edema, hypertension etc.Modern medicine study shows, Pheretima has the effect such as blood pressure lowering, blood fat reducing.

Chemical composition: containing protein, free amino acid, nucleoside, fatty acid, lumbricin, solution thermokalite, xanthine, spleen purine, guanine, multivitamin and mineral and trace element.

Pharmacological action: 1, immunity moderation power: the effect that Pheretima preserved material has obvious Promote immunity cells--macrophages to activate, concentration acts on comparatively remarkable when 5-10%.Prompting Pheretima has dual regulation to macrophage.

2, antipathogen: LUMBRICUS decoct has inhibitory action to alpha streptococcus, Pheretima alcohol extract and ligroin extraction to Bacillus tuberculosis, popularity parotitis, pertussis, herpes zoster disease have good therapeutic effect.

3, arrhythmia: the rabbit arrhythmia that rat intravenous injection earthworm decoction can resist barium chloride and ouabain healthy hair also has obvious antagonism.

4, thrombolytic, anticoagulant: Pheretima extract can obviously suppress solidifying Fibrinogen to react, promotes fibrinolysis activity.There are significant anticoagulant, thrombolytic effect.

5, diuresis: Pheretima immersion mouse mainline, significant diuresis.

In addition, Pheretima also have calmness, convulsion, relieving asthma, antiulcer, analgesia, reducing swelling and alleviating pain, the effect such as anticancer.

(7), Fructus Tribuli (Puncturevine), this product is the fruit of zygophyllaceae plant Fructus Tribuli.Property flat, bitter in the mouth, pungent, there is suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, the antipruritic function of improving eyesight.For dizzy, distending pain in the chest and hypochondrium of having a headache, breast closes mastalgia, conjunctival congestion, rubella Pruritus etc.

Chemical composition: the sweet class of steroidal soap, flavonoid, alkaloid, peroxidase and volatilization wet goods composition.

Pharmacological action: 1, resist myocardial ischemia: the thick Saponin formulations of Fructus Tribuli stem and leaf can strengthen cat and rabbit heart contractility, decreased heart rate expands strong arteria coronaria and peripheral blood vessel, has obvious function of resisting myocardial ischemia.

2, slow down aging: this effect may be relevant with adrenal cortex, makes its function exempt from exhaustion, is one of strong effect of prolonging life of this product.Research confirms, to injected in mice galactose 2mg/kg35 days, (loses weight with the subacute aging model forming carbohydrate metabolism disturbance, spleen and atrophy of thymus gland), take Fructus Tribuli total saponins, mouse spleen, thymus and body weight can be made obviously to increase, and can life span of drosophila melanogaster be extended.

3, improve blood circulation: total saponins of tribulus energy coronary artery dilating, decreased heart rate, improve coronary circulation, prevent cardiac muscle, ischemia, reduce the effects such as myocardial infarct size.Separately have report, puncture vine total saponin can improve the hemorheological property of cerebrovascular patient, and optionally can increase the blood supply at cerebral ischemia position.

4, sexual function improving: Fructus Tribuli preparation can increase libido by obvious stimulation spermiogenesis tail to male rat is oral.Give female rats then can promote to oestrus, improve reproductivity.Research shows, Fructus Tribuli excites sexual desires by improving testosterone concentration in blood.According to another report, Fructus Tribuli preparation has the effect of promotion sex gland hormones.Fructus Tribuli total saponins can promote mice sexual organ development, and water decoction can make rat testicle sertoli cytoactive raise.External own tribulus terrestris extraction develops the medicine of sexual function improving.

5, anti-myocardial ischemia: Fructus Tribuli total saponins can prevent creatine kinase activity in anoxia flush phase coronary outflow from raising, and improves myocardial cell membrane stability, reduces Hypoxic and enters cell Ca ²⁺amount, reduces membrane damage, thus protecting myocardial cell.

6, immunity is improved: Fructus Tribuli can strengthen the resistivity of mice self to ring phosphorus gland amine toxicity, and plays protection effect.

7, blood fat reducing, arteriosclerosis: water decoction exempts to take 60 days to experimental mouse hyperlipemia, can prevent cholesterolemia from raising and lipidosis, and the perfusion of Fructus Tribuli total saponins 100-240mg/kg mice also has effect for reducing blood fat.

8, resisting fatigue: total saponins of tribulus can make experimental animal have high temperature resistant, low temperature resistant, the antifatigue effect such as anoxia enduring, enhancing swimming time.

In addition, Fructus Tribuli also has blood sugar lowering, control diabetes complications, the effects such as skin whitening.

(8) Fructus Foeniculi (Fructus Foeniculi) is the dry mature fruit of umbellifer Fructus Foeniculi.Warm in nature, acrid in the mouth.Return liver,kidney,spleen, stomach warp.Kidney-replenishing, dispersing cold for relieving pain, regulating qi-flowing for harmonizing stomach, the kidney warming is had to warm up effect of liver.For colic of cold type stomachache, the flat pendant of testis, dysmenorrhea, lower abdomen pain, lack of appetite and vomiting, edema of scrotum, hydrocele of testis, to swell and ache.Modern medicine study shows, Fructus Foeniculi has enhancing immunity, fatigue-resisting function.

Chemical composition: Fructus Foeniculi is containing volatile oil, sterol, triterpene, coumarin, several amino acids, choline, acetylcholine etc.

Pharmacological action: 1, antibacterial: volatile oil is to tubercule bacillus, staphylococcus aureus inhibitory action.

2, promote liver regeneration: can make partially hepatectomized rat after Fructus Foeniculi treats 10 days, Fructus Foeniculi can make it organize regeneration degree to increase, liver WEIGHT RATIO Comparative group increases.

3, facilitating digestion: Fructus Foeniculi decoct energy isolated rabbit intestinal shrinks and promotes in the enterokinesia of body rabbit, has excitation to intestinal tube.Fructus Foeniculi gavages and can recover pentobarbital and weaken rabbit gastrointestinal motility function.

4, sex hormone function: Fructus Foeniculi acetone extractum can make the protein in testis, deferent duct reduce, can make the protein in seminal vesicle, prostate increase; To female rats, there is intravaginal keratinization and sexual cycle facilitation, and can make that mammary gland, fallopian tube, endometrium, myometrium weight increase, its effective ingredient is dimerization anethole.

In addition, Fructus Foeniculi also has the effects such as antiulcer, function of gallbladder promoting, suppression maincenter, analgesia, eliminating phlegm and relieving asthma, the anti-fibrinolytic of anticoagulant, antitumor.

(9), Fructus Crataegi (hawthorn), have another name called Fructus Pyri Pashiae fruit.For the fruit of rosaceous plant Fructus Crataegi or Crataegi cuneatae, slightly warm in nature, sour in the mouth, sweet.Return spleen, stomach, Liver Channel.There is promoting digestion and removing stagnation, promoting blood circulation to remove blood stasis., gastral cavilty distension stagnant for interior food stagnation, blood stasis amenorrhea, hyperlipidemia etc.Modern pharmacological research is thought, has blood fat reducing, blood pressure lowering, fat-reducing, blood sugar lowering, helps digest, anoxia enduring, protection gastric mucosa, regulating intestinal canal flora, relieving constipation, improves the effect such as growth promoter, antioxidation.

Chemical composition: Fructus Crataegi is containing organic acid and flavone compound, protein, aminoacid, multivitamin and mineral etc.

Pharmacological action: 1, blood fat reducing: Fructus Crataegi has the effect reducing blood cholesterol and content of triglyceride, and compositions different in Fructus Crataegi all has significant effect for reducing blood fat to various model.Fructus Crataegi extract can make HC concentration in patients with coronary heart disease blood plasma reduce gradually, and meanwhile, blood plasma TC, TG concentration significantly declines.Hawthorn extract gavages and the lipidosis on atherosclerosis rabbits cholesterolemia and organ can be made to reduce.Haw thorn granule is oral to rabbit, can reduce experimental hyperlipidemia and serum cholesterol and beta lipoprotein, has therapeutic effect to Arteries of Rabbits sclerosis.Experiment is separately had to show, pure Chinese medicinal preparation repercussive sheet based on Fructus Crataegi can make experimental cholesterol-fed rabbits serum total cholesterol and low density lipoprotein, LDL-C obviously decline, and to hyperlipidemia rats serum total cholesterol, triglyceride, the reducing effect of low density lipoprotein, LDL-C and APOB content is more obvious, and can reduce adipohepatic degree caused by high lipid diet and liver weight coefficient simultaneously.Fructus Crataegi water decoction, can the activity of enhance hepatocyte microsome and small intestinal mucosa homogenate Biosynthesis of cholesterol speed limit to Cavia porcellus gavage.It is reported, have a lot of year by Fructus Crataegi treatment hyperlipidemia and coronary heart disease abroad.Studies in China confirms, uvaol preparation, extractum have preventive and therapeutic effect to laboratory animal atherosclerosis, hypertension, hyperlipidemia.

2, blood pressure lowering: the flavone hydrolysate in Fructus Crataegi, triterpenic acid, respectively with vein, abdominal cavity and duodenum by way of administration, the blood pressure of anesthetized cat can be reduced.Fructus Crataegi total extract or Fructus Crataegi total saponins all can cause mice, rabbit and cat blood pressure drops.Experiment also proves, Fructus Crataegi and Herba Visci, Folium et Ramulus Clerodendri Trichotomi are share, and its hypotensive activity strengthens, extended durations of action.The mechanism of action of Fructus Crataegi blood pressure lowering is different because composition is different, and mainly Fructus Crataegi total flavones expansion peripheral blood vessel is main.

3, Weight-reducing and lipid-lowering: Fructus Crataegi can strengthen digestive enzyme secretion in stomach, facilitating digestion, contained lipase can promote steatolysis, and the multiple organic acid such as Crataegolic acid can improve proteinase activity, can promote that fat food digests, effectively eliminate the effect of superabundant fats in body.The function of Fructus Crataegi spleen invigorating in addition, clearing stomach, eliminate indigestion removing food stagnancy has fat-reducing, controls the effect of body weight.

4, heart tonifying: Fructus Crataegi extract can strengthen the in vitro and contractility of Bufo siccus, and the persistent period is longer.Triterpenes components stops jumping to the weak toad heart caused by naturally tired and chloral hydrate the effect that allaying tiredness or recovery beat.

5, arrhythmia: hawthorn extract to rabbit because the arrhythmia that pituitrin causes has certain inhibitory action.Fructus Crataegi flavone and saponin promote its restitution to rabbit because arrhythmia that aconitine causes also has.Triterpene acids in Fructus Crataegi can increase coronary vasodilator flow, and can improve the susceptible of cardiac muscle to cardiac glycoside, increases heart output, weakens myocardium irritability and conductivity, have anti-ventricular fibrillation, atrial fibrillation and paroxysmal arrhythmia.

6, coronary artery dilator: hawthorn extract, Fructus Crataegi flavone and saponin all have the effect of dilating coronary blood vessel, can increase coronary artery blood flow, but does not reduce myocardial oxygen consumption and coefficient of oxygen utilization.

7, increase coronary flow: Antilipemic haw granule has dilating coronary blood vessel to rabbit, dog, increase the effect of blood flow volume.Use radioactivity ⁸⁶rubidium measurement proves, Fructus Crataegi flavone hydrolyzate all can increase mice's myocardial nutritional blood flow, and wherein hydrolyzate effect is the strongest, this effect may with Fructus Crataegi dilating coronary blood vessel, improve coronary circulation relevant.

8, resist myocardial ischemia: Fructus Crataegi extract has prevention or alleviates the guinea pig myocardium ischemia or downright bad effect that isoproterenol causes, and the rabbit cause pituitrin or Acute Myocardial Ischemia in Rats also have significantly prevention and antagonism.

9, alleviating vascular spasm: hawthorn extract and hydrolyzate cause isolated vessel ring spasm to have mitigation to potassium chloride, and its remission rate is close with persantin.

10, antiplatelet aggregation: be derivant by adenosine triphosphate, observe hawthorn dry wine in vitro to the inhibitory action of rat platelet aggregation, result shows, hawthorn dry wine has certain anticoagulant effect in vitro.

11, protect the liver: Fructus Crataegi can reduce the content of SD rat tissue malonaldehyde, TC, TG caused by high fat beverage, remove the triacylglycerol piled up in liver, reduce fatty acid toxic effect on liver cells.Glutamate pyruvate transaminase, glutamic oxaloacetic transaminase, GOT index are reduced, the effect reach blood fat reducing, protecting the liver.Flavone compound has significant protective effect to the hepatic injury that many reasons causes.Further research, hawthorn extract has protective effect to the depolymerization of free yl induction hyaluronic acid, and can obviously suppress chronic alcoholism model mice liver adenosine deaminase active, shows that Fructus Crataegi has the effect of liver function protecting.

12, enhancing immunity: Fructus Crataegi all has the content of rabbit anteserum lysozyme, blood vessel coagulation antibody titre, painstaking effort lymphocyte E rosette forming rate and lymhocyte transformation rate and increases effect significantly.Display Fructus Crataegi all has facilitation to humoral immunization and cellular immunization.

13, resisting fatigue and anoxia enduring: Fructus Crataegi has antifatigue effect.Lactic acid in body can be reduced; Reduce serum urea nitrogen, promote that glycogen deposit improves hepatic glycogen content, and can the significant prolongation body hypoxia-bearing time, improve hypoxia ability, can extend the time-to-live of mice under anoxia under environment, Fructus Crataegi also has significant and anoxia functions., thus there is resisting fatigue and resisting oxygen lack.

14, antibacterial: Fructus Crataegi water decoction has stronger inhibitory action to staphylococcus aureus, anthrax, dysentery bacterium, escherichia coli.

In sum, this product has the effects such as the kidney invigorating and essence nourishing, benefiting QI and nourishing blood, nourishing liver for improving eyesight, invigorating the spleen and regulating the stomach.Be adapted to resisting fatigue, sexual function improving, prevent and treat sexual impotence, the effect such as prostatosis, raising immunity, antioxidation, defying age, life lengthening, antitumor.

Six, processing technology: 1, co-grinding: be first 40 object coarse fodders by the raw material co-grinding in formula.

2, raw water extracts: the raw material of co-grinding is divided into two equal portions, a copy of it add in the water of 1: 5-10 soak within 1-2 hour, boil lixiviate 1-3 hour after filter to get filtrate one, filter to get filtrate two after second time lixiviate raw material filtering residue adds 1: 4-8 flooding 1-2 hour, twice filtrate is mixed into water logging extracting solution.

3, raw wine lixiviate: all the other a raw materials are added lixiviate 7-15 days in 1: 8-16 Semen avenae nudae Chinese liquor (50-60 DEG C), every day shakes 1-3 time, filters to obtain steeping in wine extract.

4, water, the mixing of steeping in wine extract, stirring: the water extract obtained by first two operation and the mixing of steeping in wine extracting solution, stir.

5, precipitate: the raw material lixiviate stirred is got clarification in liquid precipitate 48-140 hour.

6, filter: the raw material leaching extracting solution after precipitation is sent into filter, filters.

7, filling and capping: the raw material leaching extracting solution after filtering is sent into filling machine, and fill is in bottle, and capping.

8, test package: by the wine after fill, be up to the standards, be packaged as finished product.

Raw material co-grinding operation is the process in order to extract the whole active component of raw material.Water and wine two kinds of extraction process lixiviate operations are in order to more effective lixiviate goes out the process of whole effective active composition in raw material.Mix and blend operation is by the obtained water logging extracting solution of front operation and the mixing of steeping in wine extracting solution, the process stirred.Precipitation operation is the process in order to improve product transparency and quality.Filter progress is the process in order to the float in filter stock leaching extracting solution and impurity.Filling and capping operation is that the raw material leaching extracting solution after filtering is sent into filling machine, in fill bottle and the process of capping.Test package operation is by the obtained semi-finished product of front operation, is up to the standards, is packaged as the process of finished product.

Seven, quality standard

1, physical and chemical index:

Wild Lycium ruthenicum Murr.	g/1000ml	12
			Wild yellow mushroom	g/1000ml	9
Wild Radix potentillae anserinae	g/1000ml	12
			Penis et testis bovis of Bos grunniens grass	g/1000ml	10
Lepidinm meyenii Walp	g/1000ml	15
			Abelmoschus esculentus	g/1000ml	10
Stichopus japonicus	g/1000ml	10
			Pheretima	g/1000ml	9
Fructus Tribuli	g/1000ml	7
			Fructus Corni	g/1000ml	8
Fructus Foeniculi	g/1000ml	3
			Fructus Crataegi	g/1000ml	15
Wine degree	％	30-38℃

2, instructions of taking: twice daily, each 20-50ml

Five, crowd is not suitable for: children and youth

Eight, embodiment: get wild Lycium ruthenicum Murr. 5-10 kilogram, wild yellow mushroom 12-22 kilogram, wild Radix potentillae anserinae 10-20 kilogram, penis et testis bovis of Bos grunniens grass 10-15 kilogram, Lepidinm meyenii Walp 15-20 kilogram, Abelmoschus esculentus 7-16 kilogram, Stichopus japonicus 6-12 kilogram, Pheretima 8-16 kilogram, Fructus Tribuli 9-18 kilogram, Fructus Corni 10-15 kilogram, Fructus Foeniculi 1-6 kilogram, Fructus Crataegi 11-20 kilogram, barley wine 500-1000L is raw material, pass through above raw material co-grinding, be divided into two equal portions, with the Chinese liquor lixiviate of water and 60 degree, first time water logging is extracted, a raw material is wherein added the water soaking of 1: 10 after 2 hours, boil lixiviate and get 2 hours, filter to get filtrate one, second time water logging is extracted water boil lixiviate that raw material filtering residue adds 1: 6 and is got and filter to get filtrate two in 1.5 hours, twice water logging extracting solution is mixed into aqueous extract, 60 degree of barley wine lixiviates are got, and another part of raw material is added 1: 10 barley wine lixiviate 15 days, every day shakes twice, be filtered into steeping in wine extracting solution, water logging extracting solution and steeping in wine extracting solution mixing and stirring, precipitate filtration in 120 hours, sends into also capping in filling machine fill bottle, be up to the standards, be packaged as finished product.

Claims (2)

1. Lepidinm meyenii Walp health preserving tonic wine (sheet) processing technology is it is characterized by: wild Lycium ruthenicum Murr. 5-10 kilogram, wild yellow mushroom 12-22 kilogram, wild Radix potentillae anserinae 10-20 kilogram, penis et testis bovis of Bos grunniens grass 10-15 kilogram, Lepidinm meyenii Walp 15-20 kilogram, Abelmoschus esculentus 7-16 kilogram, Stichopus japonicus 6-12 kilogram, Pheretima 8-16 kilogram, Fructus Tribuli 9-18 kilogram, Fructus Corni 10-15 kilogram, Fructus Foeniculi 1-6 kilogram, Fructus Crataegi 11-20 kilogram, barley wine 500-1000L be raw material.

2. processing technology: pass through above raw material co-grinding, twice water logging is extracted, once white barley wine (60 DEG C) lixiviate is got, water logging extracting solution and the mixing of steeping in wine extracting solution, stirs, precipitates, filters, filling and capping, test package become formal product.