CN110075267A - A kind of formula and preparation method of nourishing and protecting liver and sobering-up toxin-eliminating - Google Patents
A kind of formula and preparation method of nourishing and protecting liver and sobering-up toxin-eliminating Download PDFInfo
- Publication number
- CN110075267A CN110075267A CN201910252560.9A CN201910252560A CN110075267A CN 110075267 A CN110075267 A CN 110075267A CN 201910252560 A CN201910252560 A CN 201910252560A CN 110075267 A CN110075267 A CN 110075267A
- Authority
- CN
- China
- Prior art keywords
- powder
- extract
- nourishing
- sobering
- toxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses the formulas and preparation method of a kind of nourishing and protecting liver and sobering-up toxin-eliminating, including following raw material: taking water as a solvent, volume ratio number meter by weight, corn oligopeptide powder 50-150g/L, glycine betaine (natural extract) 5-10g/L, Guangdong Cordyceps militaris fruiting body powder 1-2g/L, ginseng extract powder 1-2g/L, kudzu root extract powder 1-10g/L, medlar powder 1-10g/L, hoveniae semoveniae semen powder 1-10g/L, eucommia Bark male flower powder 1-2g/L, turmeric 0.1-0.5g/L.The present invention selects the plant extract of integration of drinking and medicinal herbs to form, and prescription proportion science does not add any artificial synthesis group point, safe without toxic side effect, and there is nourishing and protecting liver, sobering-up toxin-eliminating, repair liver cell, the effect of boosting metabolism, removing free radical, improve immunity of organisms.
Description
Technical field
The present invention relates to food technology field, in particular to formula and the preparation side of a kind of nourishing and protecting liver and sobering-up toxin-eliminating
Method.
Background technique
With being constantly progressive for human society, the continuous improvement of living standard, the continuous quickening of rhythm of life, study, work
Work and life bring multiple pressure, the worsening of environment, worse and worse, people are busy with various dinner parties to air quality,
It often stays up late, smoke, drinking, lacking that movement, breathing pernicious gas, psychological pressure be big and the reasons such as diet is unreasonable, holding very much
Human body dysfunction of liver is easily led to, damage brought to human health, it is serious or even bring hepatopathy.More and more people start to infuse
Weight liver protecting, traditional liver protecting mode is by taking nourishing and protecting liver class drug, although however nourishing and protecting liver class drug
Have a certain effect to liver protecting, but consume higher, take nourishing and protecting liver class drug for a long time, human body can generate to drug according to
Lai Xing, the resistance of liver function and self-control also can be gradually reduced or even lose with repair ability, meanwhile, drug is taken for a long time
It is be easy to cause the stimulation to liver stomach function regulating, residual pharmacological property can even damage human health.Therefore, it is badly in need of developing a kind of safe protect liver
Food can achieve the purpose that liver protecting by dietetic regulation, and adjusting and improvement human body liver function that can be incremental mention
High resistance of human body and self-control and repair ability protect human health to realize liver protecting.
Summary of the invention
In view of the deficiencies of the prior art, the purpose of the present invention is to provide the formula of a kind of nourishing and protecting liver and sobering-up toxin-eliminating,
With nourishing and protecting liver, sobering-up toxin-eliminating, liver cell is repaired, is boosted metabolism, removed free radical, improve the function of immunity of organisms
Effect.
In order to achieve the above object, the technical solution of the present invention is as follows:
A kind of formula of nourishing and protecting liver and sobering-up toxin-eliminating, including following raw material: it takes water as a solvent, by weight volume ratio number
Meter, corn oligopeptide powder 50-150g/L, glycine betaine (natural extract) 5-10g/L, Guangdong Cordyceps militaris fruiting body powder 1-2g/L, people
Join extract powder 1-2g/L, kudzu root extract powder 1-10g/L, medlar powder 1-10g/L, hoveniae semoveniae semen powder 1-10g/L, eucommia Bark male flower powder
1-2g/L, turmeric 0.1-0.5g/L.
Preferably, including following raw material: taking water as a solvent, by weight volume ratio number meter, corn oligopeptide powder 50g/L, sweet tea
Dish alkali (natural extract) 5g/L, Guangdong Cordyceps militaris fruiting body powder 1g/L, ginseng extract powder 1g/L, kudzu root extract powder 1g/L, Chinese holly
Matrimony vine powder 1g/L, hoveniae semoveniae semen powder 1g/L, eucommia Bark male flower powder 1g/L, turmeric 0.1g/L.
Preferably, including following raw material: taking water as a solvent, by weight volume ratio number meter, corn oligopeptide powder 150g/L, sweet tea
Dish alkali (natural extract) 10g/L, Guangdong Cordyceps militaris fruiting body powder 2g/L, ginseng extract powder 2g/L, kudzu root extract powder 10g/L,
Medlar powder 10g/L, hoveniae semoveniae semen powder 10g/L, eucommia Bark male flower powder 2g/L, turmeric 0.5g/L.
Preferably, the eucommia Bark male flower extract the preparation method comprises the following steps: eucommia Bark male flower fresh flower is taken to be rinsed well with clear water after,
It dries, is then that distilled water, the ultrasonic extraction 30- under the ultrasonic frequency of 200-300W is added in 1:10-15 by solid-liquid ratio
60min, filtering, takes filtrate to be concentrated through rotary evaporation, then spray-dried to get eucommia Bark male flower extract.
Preferably, the Guangdong Cordyceps militaris fruiting body extract the preparation method comprises the following steps: Guangdong Cordyceps militaris fruiting body is crushed, mistake
20-60 mesh is added 75% ethanol solution refluxing extraction 1-3h by solid-liquid ratio 1:2-8, extracting solution is centrifuged, filter, in collection
Clear liquid；Then supernatant is concentrated through reduced vacuum, recycling ethyl alcohol is crushed into powder using freeze-drying to get Guangdong Cordyceps militaris
Fruiting body extract.
Preferably, the maize oligopeptide the preparation method comprises the following steps: being that 1:5-15 mixes corn protein powder and water by solid-liquid ratio
It closes uniformly, adjusts pH to 8-10, be heated to 55-75 DEG C and insulated and stirred 25-50min, be cooled to room temperature, then carry out centrifugation point
From continuing to employ slag charge；Slag charge and water are mixed evenly for 1:2-5 by solid-liquid ratio, first digested with alkali protease, high temperature goes out
Enzymolysis liquid is centrifugated by enzyme, continues to employ clear liquid；Neutral protease enzymolysis is added, enzymolysis liquid is centrifugated by high temperature enzyme deactivation,
Continue to employ clear liquid；Clear liquid is filtered through active carbon, removes high molecular weight protein, then through centrifugation exchange semi-permeable membrane filtering, be concentrated, freezing is dry
It is dry, it is crushed into powder to get maize oligopeptide.
Preferably, it is 5.5-7.5%, enzyme dosage 5-7%, temperature that the alkali protease enzymatic hydrolysis condition, which is concentration of substrate,
It is 60-70 DEG C, pH 8-9, enzymolysis time 1.5-2.5h.
Preferably, it is 5.5-7.5%, enzyme dosage 5-7%, temperature that the neutral protease enzymolysis condition, which is concentration of substrate,
It is 60-70 DEG C, pH 7-8, enzymolysis time 3-4h.
Inventive formulation can be prepared into commonly edible dosage form, for example, powder according to the conventional formulation technologies of this field
Agent, liquid, paste etc..
The groups such as excipient, preservative, sweetener can also be added when edible dosage form is made in inventive formulation as needed
Point, sweetener can be used fructose syrup, honey, rye essence, L-arabinose and mix.
Inventive formulation is preferably prepared to liquid.
The present invention also provides the preparation methods of a kind of nourishing and protecting liver and the formula of sobering-up toxin-eliminating: it takes water as a solvent, it will be beautiful
The oligomeric Gly-His-Lys of rice, Guangdong Cordyceps militaris fruiting body powder, ginseng (artificial growth) extract powder, kudzu root extract powder, medlar powder, hoveniae semoveniae semen
Powder, eucommia Bark male flower powder, turmeric are sufficiently mixed uniformly, and auxiliary material, pack is added.
Maize oligopeptide: maize oligopeptide is using corn protein powder as raw material, is sized mixing, protease hydrolyzed, separation, mistake
The relative molecular weight that the techniques such as filter, concentrate drying produce, can be without stomach in the small molecule oligopeptide of 200-1000Da
It digests and is directly absorbed, due healthcare function can be played in human body.Maize oligopeptide has Soboring-up liver-protecting, enhancing immune
The functions such as power, anti-hypertension, antifatigue promote the toxicity of body immunity while relieving alcohol.
Eucommia Bark male flower: eucommia Bark male flower is the flower that Cortex Eucommiae Xiong Shu is opened.Eucommia Bark male flower nutrition rich in and active constituent,
Middle amino acid content is up to 22% or more, zinc also rich in, iron, manganese, copper, selenium and other trace elements, nutriture value with higher
Value.Simultaneously containing liver protection, blood pressure lowering, anti-inflammatory and prevention and treatment blood circulation disorder disease lignanoids, iridoids, phenylpropyl alcohol
Plain class, flavones and other terpenoids etc., the anti-oxidant of high level, aging ingredient vitamin C and vitamin E.
Raisin Tree Seed: it is mild-natured, it is sweet in flavor.Return stomach meridian.Have effects that quench the thirst relieving restlessness, clearing away damp-heat, relieving alcoholism.Pharmacological research table
Bright, Raisin Tree Seed is able to suppress maincenter, decompression, and anti peroxidation of lipid enhances synthetic physical ability.
Fructus lycii: it is mild-natured, it is sweet in flavor.Return liver warp, kidney channel.Has effects that nourishing liver and kidney, benefiting shrewd head.Pharmacological research shows
Fructus lycii enhance immune function, anti-aging, antitumor, reducing blood lipid, liver protection, promote hematopoiesis function, anti-genetic damage, it is hypoglycemic,
Blood pressure lowering inhibits the quasi- choline effect such as heart and excited enteron aisle, enhances the hypoxia-bearing capability of mouse and extend its swimming time.
Pueraria lobata: it is cool in nature, it is sweet in flavor, pungent.Converge to the spleen channel, stomach meridian.Have effects that expelling pathogenic factors from muscles and skin bring down a fever, promote the production of body fluid, promoting eruption, Shengyang Zhixie.
It is quenched one's thirst with cure the wound cold, warm headache Xiang Qiang, dysphoria with smothery sensation, diarrhea, dysentery, ecchymosis are impermeable, hypertension, angina pectoris, deafness etc..Pharmacology is real
It tests and shows that pueraria lobata has the effect of p- receptor blocking pharmacon, be the basis of Cardiovascular；With apparent refrigeration function；It is shrinkable
Or diastole smooth muscle；Also there is expansion of coronary artery and the cerebrovascular, increase coronary blood flow and cerebral blood flow (CBF), reduce
Myocardial oxygen consumption, increase oxygen supply, reduce blood pressure, it is hypoglycemic and release intestinal tube spasm the effects of.
Guangdong Cordyceps militaris: Guangdong Cordyceps militaris fruiting body contains the effective components such as adenosine, cordycepin, cordycepic acid, Thick many candies and thick egg
The nutritional ingredients such as white, ash content, vitamin, hydrolysis amino acid, microelement, have nourishing the lung and the kidney, protect liver, it is anti-oxidant, anti-aging,
Antibacterial, improves the effects of body immunity at anti-inflammatory, calm, blood pressure lowering.
Ginseng: warm-natured, sweet in flavor, slight bitter.Thoughts of returning home warp, lung channel, the spleen channel, kidney channel.With reinforce vital energy, veins takes off admittedly, tonifying spleen
Beneficial lung, promoting production of body fluid and inducing sedation of the mind effect.With control it is physically weak to be taken off, dyspnea with shortness of breath, spontaneous perspiration limb cold, tired mind, deficiency of food are vomited and diarrhoea, the deficiency of vital energy breathes heavily
Or chronic cough, body fluid deficiency it is thirsty, quench one's thirst, insomnia and dreamful sleep, palpitation with fear amnesia, impotence, frequent micturition, all qi-blood-body fluid deficiencies disease.Pharmacology is real
The physiological function for showing that ginseng adjusts central nervous system is tested, body's immunity, heart tonifying, Hemorrhagic shock, protection and stimulation are improved
The hematopoiesis function of marrow increases cortex hormone of aadrenaline secretion, adjusts blood glucose level, significantly inhibit the absorption of cholesterol, resists swollen
Tumor delays senescence, reinforces the adaptability of body, extract can be obviously promoted the synthesis of rat organ's nucleic acid and protein.
Turmeric: it is warm-natured, it is bitter, pungent.Converge to the spleen channel, Liver Channel.With breaking blood and promoting the circulation of qi, inducing meastruation to relieve menalgia effect.Pharmacological research table
Bright, turmeric has liver protection, cholagogue, antibacterial, anti-inflammatory, antitumor, anti-AIDS, antifertility, reducing blood lipid, resisting pathogenic microbes and disease-resistant
Protozoon accelerates the effects of wound healing, anti-mutation.There is protective effect to digestive system；Increase heart coronary artery blood flow；Anticoagulation
With inhibition platelet aggregation.
Glycine betaine: glycine betaine can be extracted from the root of natural plants, stem, leaf and fruit, have antitumor, blood pressure lowering, be resisted
Peptic ulcer and gastrointestinal dysfunction treat liver diseases, play the role of nourishing and protecting liver.
Compared with prior art, the invention has the following beneficial effects:
(1) present invention selects the plant extract of integration of drinking and medicinal herbs to form, and prescription proportion science does not add any artificial synthesis group
Point, safe without toxic side effect, and there is nourishing and protecting liver, sobering-up toxin-eliminating, liver cell is repaired, is boosted metabolism, free radical is removed,
The effect of improving immunity of organisms.
(2) the maize oligopeptide Soboring-up liver-protecting in inventive formulation, the functions such as strengthen immunity, anti-hypertension, antifatigue,
Promote the toxicity of body immunity while relieving alcohol；Raisin Tree Seed and pueraria lobata reduce blood pressure, are hypoglycemic, improving lipid-metabolism, prevent
The only function of artery sclerosis, further Soboring-up liver-protecting；Eucommia Bark male flower and matrimony vine oxidation resistant delay senescence, promote blood circulation,
Further liver protecting；Guangdong Cordyceps militaris and ginseng qi-tonifying, tranquilizing the mind, improve the immunity of the human body；Turmeric liver protection, antibacterial, resists cholagogue
It is scorching；Glycine betaine nourishing and protecting liver.The present invention each substance synergistic effect, promoted while playing the function for removing toxic substances of itself sobering up and its
The function of detoxification of sobering up of the substance of interaction, and then promote the effect sobered up.Body immunity is promoted while sobering up, and is promoted
Entering fat fat metabolism promotes intestines peristalsis, enhances human immunity.
(3) present invention forms sweetener using fructose syrup, honey, rye essence, L-arabinose, and not only heat is low, sweet tea
Taste is pure, will not saprodontia, and there is certain liver protection function；Wherein, honey can improve the ingredient of blood, promote heart and brain
With blood vessel function, while there are maintenance effects to liver, liver cell regeneration can be promoted, there is certain inhibition to imitate the formation of fatty liver
Fruit；L-arabinose can inhibit body fat to accumulate, thus can be used for preventing and treating the diseases such as obesity, hypertension, hyperlipidemia.
Specific embodiment
Specific embodiments of the present invention will be further explained below.It should be noted that for these implementations
The explanation of mode is used to help understand the present invention, but and does not constitute a limitation of the invention.In addition, invention described below
Technical characteristic involved in each embodiment can be combined with each other as long as they do not conflict with each other.
Embodiment 1
A kind of formula of nourishing and protecting liver and sobering-up toxin-eliminating, including following raw material: it takes water as a solvent, by weight volume ratio number
Meter, corn oligopeptide powder 100g/L, Guangdong Cordyceps militaris fruiting body powder 1.5g/L, ginseng (artificial growth) extract powder 1.5g/L, pueraria lobata
Extract powder 5g/L, medlar powder 5g/L, hoveniae semoveniae semen powder 5g/L, eucommia Bark male flower powder 1.5g/L, turmeric 0.3g/L；Preparation method is
Said components are sufficiently mixed uniformly pack.
Above-mentioned eucommia Bark male flower extract the preparation method comprises the following steps: eucommia Bark male flower fresh flower is taken to be rinsed well with clear water after, dry, so
It is afterwards that distilled water, the ultrasonic extraction 45min under the ultrasonic frequency of 250W is added in 1:12 by solid-liquid ratio, filtering takes filtrate through revolving
Turn to be concentrated by evaporation, it is then spray-dried to get eucommia Bark male flower extract.
Above-mentioned Guangdong Cordyceps militaris fruiting body extract the preparation method comprises the following steps: Guangdong Cordyceps militaris fruiting body is crushed, cross 40 meshes, press
75% ethanol solution refluxing extraction 2h is added in solid-liquid ratio 1:5, and extracting solution is centrifuged, and filters, and collects supernatant；Then by supernatant
It is concentrated through reduced vacuum, recycling ethyl alcohol is crushed into powder using freeze-drying to get Guangdong Cordyceps militaris fruiting body extract.
Above-mentioned maize oligopeptide the preparation method comprises the following steps: be that corn protein powder is uniformly mixed by 1:10 with water by solid-liquid ratio, tune
Whole pH to 9 is heated to 65 DEG C and insulated and stirred 40min, is cooled to room temperature, then be centrifuged, continues to employ slag charge；By solid-liquid ratio
Slag charge and water are mixed evenly for 1:4, first digested with alkali protease, enzymolysis liquid is centrifugated, continues to employ by high temperature enzyme deactivation
Clear liquid；Neutral protease enzymolysis is added, enzymolysis liquid is centrifugated, continues to employ clear liquid by high temperature enzyme deactivation；By clear liquid through active carbon mistake
Filter removes high molecular weight protein, then through centrifugation exchange semi-permeable membrane filtering, is concentrated, freeze-drying is crushed into powder oligomeric to get corn
Peptide.
Embodiment 2
A kind of formula of nourishing and protecting liver and sobering-up toxin-eliminating, including following raw material: it takes water as a solvent, by weight volume ratio number
Meter, corn oligopeptide powder 50g/L, glycine betaine (natural extract) 5g/L, Guangdong Cordyceps militaris fruiting body powder 1g/L, ginseng extract powder
1g/L, kudzu root extract powder 1g/L, medlar powder 1g/L, hoveniae semoveniae semen powder 1g/L, eucommia Bark male flower powder 1g/L, turmeric 0.1g/L；System
Preparation Method is that said components are sufficiently mixed uniformly pack.
Above-mentioned eucommia Bark male flower extract the preparation method comprises the following steps: eucommia Bark male flower fresh flower is taken to be rinsed well with clear water after, dry, so
It is afterwards that distilled water, the ultrasonic extraction 30min under the ultrasonic frequency of 200W is added in 1:10 by solid-liquid ratio, filtering takes filtrate through revolving
Turn to be concentrated by evaporation, it is then spray-dried to get eucommia Bark male flower extract.
Above-mentioned Guangdong Cordyceps militaris fruiting body extract the preparation method comprises the following steps: Guangdong Cordyceps militaris fruiting body is crushed, cross 20 meshes, press
75% ethanol solution refluxing extraction 1h is added in solid-liquid ratio 1:2, and extracting solution is centrifuged, and filters, and collects supernatant；Then by supernatant
It is concentrated through reduced vacuum, recycling ethyl alcohol is crushed into powder using freeze-drying to get Guangdong Cordyceps militaris fruiting body extract.
Above-mentioned maize oligopeptide the preparation method comprises the following steps: be that corn protein powder is uniformly mixed by 1:5 with water by solid-liquid ratio, adjustment
PH to 8 is heated to 55 DEG C and insulated and stirred 25min, is cooled to room temperature, then be centrifuged, continues to employ slag charge；It is by solid-liquid ratio
Slag charge and water are mixed evenly 1:2, are first digested with alkali protease, and enzymolysis liquid is centrifugated by high temperature enzyme deactivation, continue to employ clear
Liquid；Neutral protease enzymolysis is added, enzymolysis liquid is centrifugated, continues to employ clear liquid by high temperature enzyme deactivation；By clear liquid through active carbon mistake
Filter removes high molecular weight protein, then through centrifugation exchange semi-permeable membrane filtering, is concentrated, freeze-drying is crushed into powder oligomeric to get corn
Peptide.
Embodiment 3
A kind of formula of nourishing and protecting liver and sobering-up toxin-eliminating, including following raw material: it takes water as a solvent, by weight volume ratio number
Meter, corn oligopeptide powder 150g/L, glycine betaine (natural extract) 10g/L, Guangdong Cordyceps militaris fruiting body powder 2g/L, ginseng extract powder
2g/L, kudzu root extract powder 10g/L, medlar powder 10g/L, hoveniae semoveniae semen powder 10g/L, eucommia Bark male flower powder 2g/L, turmeric 0.5g/L；
Preparation method is that said components are sufficiently mixed uniformly pack.
Above-mentioned eucommia Bark male flower extract the preparation method comprises the following steps: eucommia Bark male flower fresh flower is taken to be rinsed well with clear water after, dry, so
It is afterwards that distilled water, the ultrasonic extraction 60min under the ultrasonic frequency of 300W is added in 1:15 by solid-liquid ratio, filtering takes filtrate through revolving
Turn to be concentrated by evaporation, it is then spray-dried to get eucommia Bark male flower extract.
Above-mentioned Guangdong Cordyceps militaris fruiting body extract the preparation method comprises the following steps: Guangdong Cordyceps militaris fruiting body is crushed, cross 60 meshes, press
75% ethanol solution refluxing extraction 3h is added in solid-liquid ratio 1:8, and extracting solution is centrifuged, and filters, and collects supernatant；Then by supernatant
It is concentrated through reduced vacuum, recycling ethyl alcohol is crushed into powder using freeze-drying to get Guangdong Cordyceps militaris fruiting body extract.
Above-mentioned maize oligopeptide the preparation method comprises the following steps: be that corn protein powder is uniformly mixed by 1:15 with water by solid-liquid ratio, tune
Whole pH to 10 is heated to 75 DEG C and insulated and stirred 50min, is cooled to room temperature, then be centrifuged, continues to employ slag charge；By feed liquid
Than slag charge and water are mixed evenly for 1:5, first digested with alkali protease, enzymolysis liquid is centrifugated, stays by high temperature enzyme deactivation
Use clear liquid；Neutral protease enzymolysis is added, enzymolysis liquid is centrifugated, continues to employ clear liquid by high temperature enzyme deactivation；By clear liquid through active carbon
Filtering removes high molecular weight protein, then through centrifugation exchange semi-permeable membrane filtering, is concentrated, freeze-drying is crushed into powder low to get corn
Poly- peptide.
Above the embodiments of the present invention are described in detail, but the present invention is not limited to described embodiments.It is right
For those skilled in the art, in the case where not departing from the principle of the invention and spirit, these embodiments are carried out more
Kind change, modification, replacement and modification, still fall within protection scope of the present invention.
Claims (9)
1. the formula of a kind of nourishing and protecting liver and sobering-up toxin-eliminating, it is characterised in that: including following raw material: taking water as a solvent, by weight
Volume ratio number meter, corn oligopeptide powder 50-150g/L, glycine betaine (natural extract) 5-10g/L, Guangdong Cordyceps militaris fruiting body powder 1-
2g/L, ginseng extract powder 1-2g/L, kudzu root extract powder 1-10g/L, medlar powder 1-10g/L, hoveniae semoveniae semen powder 1-10g/L, Du
Secondary male pollen 1-2g/L, turmeric 0.1-0.5g/L.
2. the formula of nourishing and protecting liver according to claim 1 and sobering-up toxin-eliminating, it is characterised in that: including following raw material: with
Water is solvent, by weight volume ratio number meter, corn oligopeptide powder 50g/L, glycine betaine (natural extract) 5g/L, Guangdong Cordyceps militaris
Entity powder 1g/L, ginseng extract powder 1g/L, kudzu root extract powder 1g/L, medlar powder 1g/L, hoveniae semoveniae semen powder 1g/L, eucommia Bark male flower
Powder 1g/L, turmeric 0.1g/L.
3. the formula of nourishing and protecting liver according to claim 2 and sobering-up toxin-eliminating, it is characterised in that: including following raw material: with
Water is solvent, by weight volume ratio number meter, corn oligopeptide powder 150g/L, glycine betaine (natural extract) 10g/L, Guangdong Cordyceps militaris
Fructification powder 2g/L, ginseng extract powder 2g/L, kudzu root extract powder 10g/L, medlar powder 10g/L, hoveniae semoveniae semen powder 10g/L, Du
Secondary male pollen 2g/L, turmeric 0.5g/L.
4. the formula of nourishing and protecting liver according to claim 1-3 and sobering-up toxin-eliminating, it is characterised in that: the Cortex Eucommiae
Male flower extract the preparation method comprises the following steps: eucommia Bark male flower fresh flower is taken to be rinsed well with clear water after, dry, then by solid-liquid ratio be 1:
Distilled water, the ultrasonic extraction 30-60min under the ultrasonic frequency of 200-300W is added in 10-15, and filtering takes filtrate to steam through rotation
Hair concentration, it is then spray-dried to get eucommia Bark male flower extract.
5. the formula of nourishing and protecting liver according to claim 1-3 and sobering-up toxin-eliminating, it is characterised in that: the Guangdong
Cordyceps militaris sporocarp extract the preparation method comprises the following steps: Guangdong Cordyceps militaris fruiting body is crushed, cross 20-60 mesh, add by solid-liquid ratio 1:2-8
Enter 75% ethanol solution refluxing extraction 1-3h, extracting solution is centrifuged, filter, collects supernatant；Then supernatant is true through depressurizing
Sky concentration, recycling ethyl alcohol are crushed into powder using freeze-drying to get Guangdong Cordyceps militaris fruiting body extract.
6. the formula of nourishing and protecting liver according to claim 1-3 and sobering-up toxin-eliminating, it is characterised in that: the corn
Oligopeptide the preparation method comprises the following steps: be that corn protein powder is uniformly mixed by 1:5-15 with water by solid-liquid ratio, adjust pH to 8-10, heat
To 55-75 DEG C and insulated and stirred 25-50min, it is cooled to room temperature, then be centrifuged, continues to employ slag charge；It is 1:2- by solid-liquid ratio
5 slag charge and water are mixed evenly, and are first digested with alkali protease, and enzymolysis liquid is centrifugated by high temperature enzyme deactivation, continue to employ clear
Liquid；Neutral protease enzymolysis is added, enzymolysis liquid is centrifugated, continues to employ clear liquid by high temperature enzyme deactivation；By clear liquid through active carbon mistake
Filter removes high molecular weight protein, then through centrifugation exchange semi-permeable membrane filtering, is concentrated, freeze-drying is crushed into powder oligomeric to get corn
Peptide.
7. the formula of nourishing and protecting liver according to claim 6 and sobering-up toxin-eliminating, it is characterised in that: the alkali protease enzyme
Solution condition is that concentration of substrate is 5.5-7.5%, and enzyme dosage 5-7%, temperature is 60-70 DEG C, pH 8-9, and enzymolysis time is
1.5-2.5h。
8. the formula of nourishing and protecting liver according to claim 6 and sobering-up toxin-eliminating, it is characterised in that: the neutral proteinase enzyme
Solution condition is that concentration of substrate is 5.5-7.5%, and enzyme dosage 5-7%, temperature is 60-70 DEG C, pH 7-8, enzymolysis time 3-
4h。
9. a kind of preparation method of the formula of nourishing and protecting liver according to claim 1-8 and sobering-up toxin-eliminating, special
Sign is: taking water as a solvent, corn oligopeptide powder, Guangdong Cordyceps militaris fruiting body powder, ginseng (artificial growth) extract powder, pueraria lobata are mentioned
Object powder, medlar powder, hoveniae semoveniae semen powder, eucommia Bark male flower powder, turmeric is taken to be sufficiently mixed uniformly pack.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910252560.9A CN110075267A (en) | 2019-03-29 | 2019-03-29 | A kind of formula and preparation method of nourishing and protecting liver and sobering-up toxin-eliminating |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910252560.9A CN110075267A (en) | 2019-03-29 | 2019-03-29 | A kind of formula and preparation method of nourishing and protecting liver and sobering-up toxin-eliminating |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110075267A true CN110075267A (en) | 2019-08-02 |
Family
ID=67413989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910252560.9A Withdrawn CN110075267A (en) | 2019-03-29 | 2019-03-29 | A kind of formula and preparation method of nourishing and protecting liver and sobering-up toxin-eliminating |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110075267A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112471376A (en) * | 2020-11-02 | 2021-03-12 | 辽宁康汇医学临床研究有限公司 | Solid beverage for preventing and treating alcoholic fatty liver and preparation method thereof |
-
2019
- 2019-03-29 CN CN201910252560.9A patent/CN110075267A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112471376A (en) * | 2020-11-02 | 2021-03-12 | 辽宁康汇医学临床研究有限公司 | Solid beverage for preventing and treating alcoholic fatty liver and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106722963A (en) | A kind of vegetarian diet meal | |
| CN101904390B (en) | Liver-nourishing tea and preparation method thereof | |
| CN101558872B (en) | Brain strengthening drink and method for preparing soy protein powder | |
| CN101603010A (en) | A kind of fast cultivation method for Taisui | |
| CN103602551B (en) | Compound traditional Chinese medicinal herbal fermented health-care liquor for promoting digestion and strengthening stomach and production method thereof | |
| CN106174474A (en) | A kind of it is applicable to the special dietary seafood that Patients with Cardiovascular/Cerebrovascular Diseases is edible | |
| CN106107397A (en) | A kind of Andrias davidianus Blanchard protein peptide powder solid beverage formula and preparation method thereof | |
| CN107136375A (en) | A kind of polygonatum Solomon's seal solid beverage | |
| CN102366133A (en) | Nutritional healthy beverage and preparation method thereof | |
| CN110075266A (en) | One breeding kidney reinforces the kidney the formula to fill blood and preparation method | |
| CN102511876B (en) | Hawthorn red jujube thick syrup and production process thereof | |
| CN102652575A (en) | Golden-silk jujube health-care drink and producing method thereof | |
| CN100574786C (en) | A kind of production technology of tortoise preparation | |
| CN110075267A (en) | A kind of formula and preparation method of nourishing and protecting liver and sobering-up toxin-eliminating | |
| CN106689390A (en) | Nine-seed milk and making method thereof | |
| CN105154304A (en) | Black garlic vinegar and preparing method thereof | |
| CN108690775B (en) | Production method of health-preserving and health-care white spirit, health-preserving and health-care white spirit and use method thereof | |
| CN102511882A (en) | Red jujube thick syrup beneficial for improving growth and development | |
| CN110679935A (en) | Burdock and ginseng essence cream and preparation method thereof | |
| CN107095254A (en) | A kind of flavoring with nutrition health-care functions | |
| CN111184194A (en) | Giant salamander peptide dried konjac and production method thereof | |
| KR20210041387A (en) | A natural tea removing the effect of hangover contained the extract material in arrowroot blossoms and Plantago ovata | |
| CN109717437A (en) | One kind is relieved the effect of alcohol compound honey paste and preparation method thereof | |
| CN110250411A (en) | A kind of Saussurea involucrata culture health nutrient meal | |
| CN108783443A (en) | A kind of tablet and preparation method thereof for internal organs conditioning |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190802 |