CN111543632A - Composition for resisting anoxia, resisting fatigue and assisting in improving memory - Google Patents

Composition for resisting anoxia, resisting fatigue and assisting in improving memory Download PDF

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CN111543632A
CN111543632A CN202010292619.XA CN202010292619A CN111543632A CN 111543632 A CN111543632 A CN 111543632A CN 202010292619 A CN202010292619 A CN 202010292619A CN 111543632 A CN111543632 A CN 111543632A
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composition
parts
mice
resisting
fatigue
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李晓莉
张恒
黄进
刘磊
张少杰
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Army Service Academy of PLA
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Army Service Academy of PLA
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
    • A21D13/00—Finished or partly finished bakery products
    • A21D13/80—Pastry not otherwise provided for elsewhere, e.g. cakes, biscuits or cookies
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/14—Organic oxygen compounds
    • A21D2/18—Carbohydrates
    • A21D2/181—Sugars or sugar alcohols
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/36—Vegetable material
    • A—HUMAN NECESSITIES
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    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/60—Sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

The invention provides a composition for resisting anoxia, resisting fatigue and assisting in improving memory, which comprises the following components: 3-6 parts of highland barley beta-glucan by mass; 5-10 parts by mass of hawthorn total flavonoids; 2-4 parts of potentilla anserine polysaccharide. The composition provided by the invention has the effects of resisting anoxia, resisting fatigue and assisting in improving memory.

Description

Composition for resisting anoxia, resisting fatigue and assisting in improving memory
Technical Field
The invention belongs to the technical field of health care products, and particularly relates to a composition for resisting anoxia, resisting fatigue and assisting in improving memory.
Background
More and more residents need to go to the anoxic areas of western highlands to conduct various economic trade activities. The altitude reaction caused by the oxygen-poor environment of the plateau brings great threat to life, work and health of people going to the plateau, and causes the function reduction, physical ability reduction and memory impairment of the cardiovascular system. In daily life, hypoxia may be caused to tissues, health may be impaired, and physical fatigue may be caused due to respiratory diseases, strenuous exercise, high-intensity mental work, work in a plateau hypoxic region, and the like.
At present, health care products for relieving fatigue, improving memory and the like are poor in economy, safety and various forms. Some may also have side effects. Therefore, there is a lack of a good health product for improving anoxia endurance, relieving physical fatigue and assisting in improving memory.
Disclosure of Invention
The invention aims to provide a composition for resisting anoxia, resisting fatigue and assisting in improving memory, which can improve anoxia tolerance, relieve physical fatigue and assist in improving memory.
In a first aspect, the present invention provides a composition for resisting anoxia, resisting fatigue, and assisting to improve memory, comprising:
3-6 parts of highland barley beta-glucan
5-10 parts by mass of hawthorn total flavonoids
2-4 parts of potentilla anserine polysaccharide.
In an optional embodiment, the highland barley beta-glucan is 4.5 parts by mass, the hawthorn total flavonoids are 6-9 parts by mass, and the potentilla anserina polysaccharides are 2.5-3.5 parts by mass.
In a second aspect, the present invention provides a health product capsule, wherein the active ingredient of the health product capsule is the composition described in any one of the above embodiments.
In an optional embodiment, each capsule contains 2-5 g of effective components.
In a third aspect, the embodiment of the present invention provides a tablet for health products, wherein the active ingredient of the tablet is the composition described in any one of the above embodiments.
In a fourth aspect, embodiments of the present invention provide a use of a composition according to any one of the above embodiments in the diet.
In alternative embodiments, the diet includes solid foods and liquid beverages.
In an alternative embodiment, the composition is added directly to the diet.
The composition disclosed by the invention can improve anoxia tolerance, relieve physical fatigue and assist in improving memory. In the composition, the components adopt pure natural food raw material extracts, so that the composition has no side effect of any Chinese and western medicines, and is safe and healthy. The composition of the embodiment of the application can be added into daily food or independently prepared into food for eating, and the utilization form is rich. The raw materials are economical, the market sources are wide, and the health-care food is suitable for being eaten for a long time to improve the health level and is economical and practical.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.
The summary of various implementations or examples of the technology described in this application is not a comprehensive disclosure of the full scope or all features of the disclosed technology.
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FIG. 1 is a graph of mean distance between the runout of hypoxic mice in different groups of gavage cycles.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below with reference to the embodiments of the present application. It should be apparent that the described embodiments are only some of the embodiments of the present application, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the described embodiments of the application without any inventive step, are within the scope of protection of the application.
Unless defined otherwise, technical or scientific terms used herein shall have the ordinary meaning as understood by one of ordinary skill in the art to which this application belongs. The use of "first," "second," and the like in this application does not denote any order, quantity, or importance, but rather the terms first, second, and the like are used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that the element or item listed before the word covers the element or item listed after the word and its equivalents, but does not exclude other elements or items. The terms "connected" or "coupled" and the like are not restricted to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "upper", "lower", "left", "right", and the like are used merely to indicate relative positional relationships, and when the absolute position of the object being described is changed, the relative positional relationships may also be changed accordingly.
Detailed descriptions of known functions and known components are omitted in the present application in order to keep the following description of the embodiments of the present application clear and concise.
The embodiment of the application provides a composition for resisting anoxia, resisting fatigue and assisting in improving memory, which comprises:
3-6 parts of highland barley beta-glucan
5-10 parts by mass of hawthorn total flavonoids
2-4 parts of potentilla anserine polysaccharide.
The composition provided by the embodiment of the application can improve anoxia tolerance, relieve physical fatigue and assist in improving memory. In the composition of the embodiment, the components are all natural food raw material extracts, so that the composition is free from any side effect of Chinese and western medicines, safe and healthy. The raw materials are economical in price, the market sources are wide, and the health-care food is suitable for being eaten for a long time to improve the health level, and is economical and practical.
In some embodiments, the compositions of the embodiments of the present application comprise the following effective components in parts by mass: 4.5 parts of highland barley beta-glucan, 6-9 parts of hawthorn total flavonoids and 2.5-3.5 parts of potentilla anserina polysaccharides. In an exemplary embodiment, the mass parts of the effective components are as follows: 4.5 parts of highland barley beta-glucan, 7-8 parts of hawthorn total flavonoids and 2.5-3.5 parts of potentilla anserina polysaccharides. For example, the mass parts of the effective components in the composition are as follows: 4.5 parts of highland barley beta-glucan, 7.5 parts of hawthorn total flavonoids and 3 parts of potentilla anserina polysaccharide.
The components of the compositions of the examples of this application are mixed together.
The present embodiments also provide a use of the composition of any of the above embodiments in a diet.
The diet of the embodiments of the present application includes solid foods and liquid beverages. In an exemplary embodiment, the solid food may include pastries. Liquid beverages may include tea beverages, fruit juice beverages, carbonated beverages, and the like.
The compositions of the embodiments of the present application can be added to the daily diet for administration. Can also be independently prepared into food for eating or prepared into drink for drinking, and has rich utilization forms.
The composition of the embodiment of the application mainly comprises dietary fibers and flavonoids, and the addition of the composition does not easily influence the properties of food and can improve the taste and shelf life of the food. The composition of the embodiments of the present application is very simple to add to daily food or to prepare into food alone for eating. For example, when added to daily foods, it may be added directly. When the extract is separately prepared into food, it can be directly mixed with raw materials. Does not affect the preparation of food.
In an exemplary embodiment, the composition of the embodiments of the present application may be mixed into a meal for direct consumption at the time of eating. The compositions of the examples herein can also be added directly to drinking water for drinking.
In exemplary embodiments, the composition of the embodiments of the present application can be added to any existing food or beverage as a raw material without changing the formulation and preparation process of other raw materials.
The daily dose of the composition of the present embodiment may be 10g to 20 g.
The amount of the combination of the embodiments of the present application added to a food or beverage can be determined according to the amount of the food or beverage generally consumed by a person. The food or drink may be generally consumed in an amount of 10g to 20g of the composition of the examples of the present application. For example, a 330ml canned beverage may contain 10g to 20g of the composition of the examples of the present application. The bottled beverage of 500ml may contain 10g to 20g of the composition of the examples of the present application. The bread of 100g may contain 10g to 20g of the composition of the examples of the present application. Of course, the amount of the composition of the examples of the present application added to the diet is not limited thereto.
The embodiment of the application provides a health-care product capsule, and the effective component of the health-care product capsule is the composition in any embodiment.
The composition of the examples of the present application can be directly filled into capsule shells. The composition of the embodiment of the application is prepared into capsules, and is convenient to carry and take. The dosage of the medicine taken each time can be mastered more accurately. The capsules may be of different sizes, e.g. 5 g/capsule, 2.5 g/capsule etc.
The embodiment of the application provides a health product tablet, and the effective component of the health product tablet is the composition in any embodiment.
The composition of the embodiment of the application is prepared into tablets together with other auxiliary materials, and is convenient to carry and take. The dosage of the medicine taken each time can be mastered more accurately. The tablets may be of different sizes. The tablet can be chewed, swallowed or dissolved in water for drinking.
The raw materials adopted by the combination in the embodiment of the application can be all edible raw materials sold in the market. For example, the compositions of the various examples of the present application were formulated using the raw materials from the sources shown in table 1 below.
Table 1 description of the composition Components
Figure BDA0002450807220000051
The purity of the raw materials of the effective components is not 100 percent, so the raw materials are converted into the amount of the effective components to be prepared according to the proportion during preparation.
Example 1
A composition for resisting anoxia, relieving fatigue, and improving memory comprises: 3 parts of highland barley beta-glucan, 5 parts of hawthorn total flavonoids and 2 parts of potentilla anserine polysaccharide.
Example 2
A composition for resisting anoxia, relieving fatigue, and improving memory comprises: 6 parts of highland barley beta-glucan, 10 parts of hawthorn total flavonoids and 2 parts of potentilla anserine polysaccharide.
Example 3
A composition for resisting anoxia, relieving fatigue, and improving memory comprises: 3 parts of highland barley beta-glucan, 5 parts of hawthorn total flavonoids and 4 parts of potentilla anserine polysaccharide.
Example 4
A composition for resisting anoxia, relieving fatigue, and improving memory comprises: 5 parts of highland barley beta-glucan, 7 parts of potentilla anserine polysaccharide and 3 parts of hawthorn total flavonoids.
Example 5-example 8
The compositions of examples 1-4 were separately filled into capsules.
Examples 9 to 12
The compositions of examples 1-4 were each tableted.
The effects of the compositions of the present application are illustrated below by the relevant experiments.
1. Experiment of effective time for eating
Experiments prove that: experiment of mouse runner fatigue tester in different gavage periods
The experimental method comprises the following steps: male SPF grade Balb/C mice were used for 6, 8, 9 weeks, and were grouped 7 days after acclimation as follows: 10 mice with the weight of 18-20G and the age of 6 weeks are arranged into G30 groups, and the stomach is perfused for 30 days; 10 mice with the weight of 19-21 g and the age of 8 weeks are set as 615 groups, and the mice are gavaged for 15 days; 10 mice with the weight of 20-22G and the age of 9 weeks are arranged into G7 groups and are subjected to intragastric administration for 7 days. Gavage formulations were performed according to the composition of example 1 of the present application, with the specific groupings and administration as shown in table 2.
TABLE 2 Experimental groups and mouse doses
Figure BDA0002450807220000061
Note: the administration volume is 0.25ml/10g, n is 10
After the gavage period is finished, a runner fatigue meter experiment is carried out in a 12% oxygen concentration low-oxygen chamber, and the exhaustion time, distance and electric shock times of each group of mice are recorded. The parameters of the runner fatigue tester are as follows: the rotating speed is 18.0r/min, the difficulty coefficient is 1, the current is 1.5mA, and the electric shock tolerance time is 3.0 s. Exhaustion setting: the electric shock rest time is 30s, and the patient can rest for 6 times within 10 min. The patient is fasted for 12 hours before last gastric lavage without water supply, the blank constant oxygen group is in normal environment, and the blank anoxic group and the formula group are placed in a low-pressure oxygen chamber. And (3) after the mice are subjected to last gastric lavage for 1 hour, putting the mice into a runner fatigue instrument until the runner stops when the mice are exhausted.
And (4) experimental conclusion: the mean values of the running power exhaustion distances of the groups of mice in the wheel fatigue machine are counted after the experiment, and are shown in figure 1.
The running data of each group of mice is analyzed by single-factor variance, and the exhausted running distance of the mice is obviously reduced by P (0.044) to 0.05 compared with G15 and G30 according to G7; g15 did not differ significantly from G30 by P0.886 > 0.05. It is believed that after 15 days of gavage, the composition began to significantly improve the anti-fatigue and anti-hypoxia abilities of the mice. The effective time for eating of the composition of the embodiment of the application is more than 15 days.
2. Improving anoxia tolerance.
Experiments prove that: normal pressure closed hypoxia experiment and acute cerebral ischemic hypoxia experiment.
The experimental method comprises the following steps: after the SPF-grade Balb/C male mice with the weight of 18-22 g and the age of 6-8 weeks are used and fed for 7 days adaptively, the mice are randomly grouped according to the weight, 10 mice in each group are grouped as shown in the table 3. The gavage scheme is converted into animal dose according to the dose listed in examples 1-4, the blank control group is subjected to gavage by normal saline according to the weight and the administration volume, a normal pressure closed hypoxia experiment and an acute cerebral ischemic hypoxia experiment are carried out after the last gavage for 15 days after the gavage, and the experimental method is according to the technical specification for health food inspection and evaluation (2003 edition).
TABLE 3 Experimental groups and mouse dosing
Figure BDA0002450807220000062
Figure BDA0002450807220000071
Note: the administration volume is 0.25ml/10g, n is 10
And (4) experimental conclusion: compared with the blank control group, the survival time of the normbaric occlusion hypoxia experiment of the mice in the example 1-4 dose groups is improved to different degrees and is significantly different (the P of the example 1 dose group is 0.047, the P of the example 2 dose group is 0.036, the P of the example 3 dose group is 0.027, and the P of the example 4 dose group is 0.006). Compared with the blank control group, the acute cerebral ischemic hypoxia experiment wheeze time of the mice of the example 1-4 dose groups is improved to different degrees and is obviously different (the P of the example 1 dose group is 0.041, the P of the example 2 dose group is 0.050, the P of the example 3 dose group is 0.031, and the P of the example 4 dose group is 0.016). Compared with the blank control group, the weight change and the food intake of each group after gastric lavage for 15 days have no statistical difference, and the composition is proved to have no influence on the normal development and health of the mice.
3. And physical fatigue is relieved.
Experiments prove that: and (3) carrying out a mouse runner fatigue instrument experiment.
The experimental method comprises the following steps: after the SPF-grade Balb/C male mice with the weight of 18-22 g and the age of 6-8 weeks are used and fed for 7 days adaptively, the mice are randomly grouped according to the weight, 10 mice are in each group, and the grouping and the gavage scheme are the same as the table 3. After 15 days of gastric lavage, the mice are put into a low oxygen chamber with 10 percent oxygen concentration in advance for 12 hours, the water is not cut off after food is stopped, and the rotating wheel fatigue instrument experiment of the mice is carried out after 1 hour of last gastric lavage. The setting and data recording of the runner fatigue instrument are the same as those of experiment 1, and sampling is carried out after the experiment is finished to detect myoglycogen, serum lactic acid and serum urea nitrogen in skeletal muscle of the mouse, and malondialdehyde, superoxide dismutase and glutathione peroxidase in liver tissues.
And (4) experimental conclusion: compared with the blank control group, the mice in the example 1-4 dose groups have different degrees of elevation of the exhausted running distance and have significant differences (the P of the example 1 dose group is 0.041, the P of the example 2 dose group is 0.037, the P of the example 3 dose group is 0.024, and the P of the example 4 dose group is 0.042). The composition provided by the embodiment of the application is proved to be effective in relieving physical fatigue of hypoxic mice. The content of glycogen in skeletal muscle of mice in dose groups of examples 1 to 4 is obviously higher than that of mice in a blank control group, and the content of serum urea nitrogen is obviously lower than that of mice in the blank control group, so that the doses of the examples can improve the glycogen storage of the body, improve the oxygen supply and energy supply level of the body and reduce the oxidative decomposition of protein and amino acid in the body. In examples 1-4, the malondialdehyde content in the liver tissue of the mice in the dose groups is very significantly lower than that in the blank control group, and the activities of superoxide dismutase and glutathione peroxidase are very significantly higher than that in the blank control group, which indicates that the composition disclosed by the embodiment of the application has good antioxidation, can effectively inhibit the peroxidation of body lipid, improve the activity of the antioxidase and reduce the tissue peroxidation damage caused by hypoxia.
There were no significant differences in weight variation and feed intake changes for each group during this experiment, demonstrating that the compositions of the examples of the present application did not affect normal development and health.
4. Can assist in improving memory.
Experiments prove that: and (4) identifying a new object.
The experimental method comprises the following steps: after the SPF-grade Balb/C male mice with the weight of 18-22 g and the age of 6-8 weeks are used and fed for 7 days adaptively, the mice are randomly grouped according to the weight, 10 mice are in each group, and the grouping and the gavage scheme are the same as the table 3. The gavage protocol was converted to animal dose according to the doses listed in examples 1-4, the blank control group was gavaged with physiological saline according to body weight and administration volume, and the mice were placed in a 10% oxygen concentration hypoxic chamber 24 hours before gavage 15 days, and were taken without food and water. The new object identification experiment was then carried out as follows.
A black shading film was used to perform shading treatment using an acryl box having a length of about 40cm per side. Exactly the same 4cm diameter cylindrical objects (A)2 and 4cm side square objects (B)1 were prepared.
Starting Panlab smart3.0.0.3 behavioral recognition software and camera equipment of Harvard Apparatus company, putting the mouse into a new object recognition box for placing the same object A for the first time after the last gastric lavage for 1h, putting the two objects at the left and right ends of the box body close to the same side wall, keeping a distance of 10cm from the nearest box wall, putting the mouse into the box body in a position back to the object and at the same distance as far as possible from the two objects, and taking out the mouse after 10 min. After the taken mice rest for 1h, one object (A) is changed into an object (B), the mice familiar with the object (A) are placed into the recognition box again in the same way, and the software automatically recognizes and records the effective exploration time when the mice enter the range of 1cm between the two objects. The software sets three-point identification of a tip, a neck and a tail root to position the mouse, when the three-point connecting line direction of the mouse points to the object and the mouth is opposite to the object, the mouse is contacted with or the tip of the mouth enters the range of 1cm of the object and smells, namely the mouse is considered to be effectively explored (the mouse is not opposite to the object, the mouse turns the head or climbs the object and is not considered to be effectively explored) by the system for 3min and then is taken out. The whole experiment process is completed in a low-oxygen chamber, the action of a mouse is prevented from being interfered by sound in the experiment process, after each mouse completes an experiment identification experiment once and leaves an identification box, the inside of the box is wiped by 75% ethanol, and the action of the next animal is prevented from being interfered by odor. And recording the total search distance, the search time of the old object and the search time of the new object of the mouse so as to evaluate the memory state of the mouse.
Rodents have an innate curiosity about novelty, mice tend to have more search and contact for novelty objects, and mice have good memory of previously contacted objects (a), do not tend to search for old objects, and tend to search for new objects (B). Evaluation was performed using object recognition ratio (DR), and the larger the coefficient value, the better the memory of the mouse. The time of the old object (A) explored by the mice collected by Smart software is marked as TAThe time for searching for the new object (B) is denoted as TBThe object recognition coefficient is expressed as DR, and the calculation is disclosed as:
DR＝(TB-TA)/(TB+TA) The DR value is in the range of [ -1 to 1 [)]。
The total distance explored was also examined for mice.
After the experiment is finished, the brain tissue of the mouse is taken to detect malondialdehyde, superoxide dismutase and glutathione peroxidase, and the expression quantity of Bc1-2, Bax and Caspase-3 is detected by an Elisa method.
And (4) experimental conclusion: compared with the blank control group mice, the object recognition coefficients of the mice in the example 1-4 dose groups are improved to different degrees, and the differences are obvious (the P of the example 1 dose group is 0.046, the P of the example 2 dose group is 0.031, the P of the example 3 dose group is 0.040, and the P of the example 4 dose group is 0.033). The compositions of the dose groups of examples 1-4 are shown to help improve memory in hypoxic mice. In a mechanism, the composition of the embodiment can obviously reduce the content of malondialdehyde in brain tissues, improve the activities of antioxidase such as superoxide dismutase and glutathione peroxidase, obviously reduce the expression levels of cell apoptosis key factors Bax and Caspase-3, improve the expression levels of Bc1-2 to different degrees, inhibit the start of the apoptosis program of brain cells, and play a role in preventing the brain tissues from being unbalanced in free radical metabolism and over-oxidized damage caused by oxygen deficiency, thereby playing a role in assisting in improving memory.
There were no significant differences in weight variation and feed intake changes for each group during this experiment, again demonstrating that the compositions of the present application did not affect normal development and health.
The above description is intended to be illustrative and not restrictive. For example, the above-described examples (or one or more versions thereof) may be used in combination with each other, and it is contemplated that the embodiments may be combined with each other in various combinations or permutations. The scope of the application should be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled.

Claims (8)

1. A composition for resisting anoxia, relieving fatigue, and improving memory comprises:
3-6 parts of highland barley beta-glucan
5-10 parts by mass of hawthorn total flavonoids
2-4 parts of potentilla anserine polysaccharide.
2. The composition as claimed in claim 1, wherein the amount of said highland barley β -glucan is 4.5 parts by mass, the amount of said hawthorn total flavonoids is 6-9 parts by mass, and the amount of said potentilla anserina polysaccharides is 2.5-3.5 parts by mass.
3. A nutraceutical capsule comprising as an active ingredient the composition of claim 1 or 2.
4. A health product capsule according to claim 3, wherein the effective component of each capsule is 2-5 g.
5. A tablet for health care products comprising the composition according to claim 1 or 2 as an active ingredient.
6. Use of a composition according to claim 1 or 2 in the diet.
7. The use of claim 6, wherein the diet comprises solid foods and liquid beverages.
8. The use according to claim 6, wherein the composition is added directly to the diet.
CN202010292619.XA 2020-04-14 2020-04-14 Composition for resisting anoxia, resisting fatigue and assisting in improving memory Pending CN111543632A (en)

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CN115997833A (en) * 2022-12-01 2023-04-25 中国人民解放军陆军勤务学院 Female freeze-dried functional tea suitable for plain plateau settlement environment and preparation method thereof
CN117859917A (en) * 2023-12-29 2024-04-12 北京联合大学 Preparation with memory improving capability and preparation method thereof

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CN117859917A (en) * 2023-12-29 2024-04-12 北京联合大学 Preparation with memory improving capability and preparation method thereof

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