JP5601747B2 - Composition for internal use for fatigue prevention and preparation for internal use for fatigue prevention - Google Patents

Description

  The present invention relates to a composition for internal use for fatigue prevention, which contains black garlic produced by fermenting raw garlic and ginseng as active ingredients and exhibits fatigue prevention effects. The present invention also relates to a preparation for internal use for preventing fatigue comprising the composition for internal use for preventing fatigue.

  Fatigue is related to a decrease in sustained motor ability based on the lack of ATP as a biochemical component, muscle pain due to accumulation of lactic acid, etc., which is based on physical muscle cell damage or exhaustion, and means mental stress It is said to be an abstract word that combines fatigue feelings.

  As anti-fatigue agents (fatigue preventive agents), there have been nourishing tonic foods or beverages containing garlic, vitamins, caffeine, royal jelly, etc., but garlic has a unique stimulating odor for allicin, which is an active ingredient. Therefore, it is difficult to use it as it is.

  Therefore, Patent Document 1 discloses that raw garlic is fermented with brown rice fermentation enzyme to reduce the garlic odor during and after eating.

  As a method for strengthening the active ingredient of garlic, raw garlic is stored in a temperature range of 30 ° C. to 75 ° C. for a predetermined period and then taken back to room temperature, and cycloaliin and / or S-allyl cysteine having a thrombus preventing effect is added. Patent Document 2 discloses a processed garlic which is accumulated at a high concentration and has enhanced physiological activity, and a method for producing the same.

  In addition, fermented black garlic in which raw garlic is aged within a temperature range of 55 ° C to 80 ° C and a humidity range of 70% to 95% as garlic that does not generate a garlic odor during exhalation after feeding and has excellent physiological activity, and its production A method is disclosed in US Pat.

  On the other hand, ginseng (ginseng) has also been prized as a herbal medicine with nourishing and tonic effects since ancient times, but in recent years it has also been used for health foods. For example, Patent Document 4 discloses a health drink containing a ginseng medicinal ingredient and a high sugar content plum solution extracted from plum and sugar.

In addition, by reacting ginseng extract with a microorganism or enzyme having cellulose hydrolyzing activity and / or starch hydrolyzing activity, the physiologically active ingredient is retained as it is, and it is refreshing without adding a sweetener. A sweet ginseng saccharified sweet food and a method for producing the same are disclosed in Patent Document 5.
JP 2004-121113 A JP 2005-278635 A JP 2006-149325 A JP-A-6-277014 Japanese Patent Laid-Open No. 10-14523

  As described above, both garlic and ginseng have been used as foods having nourishing and tonic effects, but it has been difficult to say that the fatigue prevention effect on humans can be fully realized. Moreover, it was the same when garlic or ginseng was used in combination with other foods or herbal medicines having nourishing tonic effects.

  An object of the present invention is to provide a composition for internal use for fatigue prevention in which the nourishing tonic effect of garlic and ginseng is synergistically increased, and a preparation for internal use for fatigue prevention containing the composition.

  As a result of diligent research, the inventors of the present invention show that, when black garlic produced by fermenting raw garlic and ginseng are used in combination, the nourishing tonic effect (fatigue prevention effect) is exhibited synergistically. As a result, the present invention has been completed.

Specifically, the present invention
A powder of black garlic produced by fermenting raw garlic, related to fatigue prophylactic in dosage composition containing a ginseng as an active ingredient.

Although there are health foods and pharmaceuticals containing garlic or ginseng, the composition for internal use for fatigue prevention of the present invention is a combination of black garlic powder produced by fermenting raw garlic and ginseng, It has a high fatigue prevention effect (nourishing tonic effect) that is not found in the combination of garlic and ginseng.

Black garlic, have preferably be raw garlic is black garlic produced by self-fermentation. This is because when used in combination with ginseng, a higher fatigue prevention effect is recognized than other types of black garlic.

Rei Ko carrots is not preferable to be a dry extract. In addition, an excipient may be added to black garlic powder and ginseng as appropriate, or a liquid may be prepared with an appropriate solvent.

In the composition for internal use for preventing fatigue according to the present invention, the blending ratio of black garlic powder and ginseng can be 20% by weight as long as the effect of the present invention is not impaired. 1 to 1: 2 and it is not preferable.

In the composition for internal use for preventing fatigue according to the present invention, the blending ratio of black garlic powder and ginseng is more preferably 15: 1 to 1: 1 by weight. When the weight ratio of ginseng is 1/15 or more of black garlic powder , the synergistic fatigue prevention effect (nourishing tonic effect) of both is more prominent. Further, when the weight ratio of black garlic powder is higher than that of ginseng, a more synergistic fatigue prevention effect (nourishing tonic effect) is exhibited. In this case, since ginseng is very expensive, there is also an advantage that the manufacturing cost of the composition can be suppressed.

Fatigue prophylactic in dose composition of the present invention, it is not preferable oral dose per day is less than 0.3 mg / kg body weight or higher 400 mg / body weight kg. The maximum allowable intake of black garlic is considered to be about 15 g / day for healthy individuals, and the maximum allowable intake for ginseng is considered to be about 5 g / day. That is, the combined amount is 20 g / day, and assuming that the weight of a healthy person is 50 kg, 400 mg / kg body weight.

  Further, by eating the composition for internal use for preventing fatigue of the present invention of about 15 mg or more per day, the fatigue preventive effect (nutrition tonic effect) referred to in the present invention starts to appear more prominently. Assuming that the weight of a healthy person is 50 kg, it is 0.3 mg / kg body weight.

  Therefore, the daily oral dose of the composition for internal use for preventing fatigue according to the present invention is preferably 0.3 mg / kg to 400 mg / kg of body weight. In consideration of the efficacy and safety when taking for a long time, and the cost of ginseng, the daily oral dose is more preferably 6.6 mg / kg to 140 mg / kg of body weight.

  The composition for internal use of the present invention can be used as a functional food, and can also be used as a quasi-drug, a component of food and drink, a food additive, and the like. In addition, liquid drinks, such as a functional drink, are also contained in the composition for internal use of this invention.

The present invention also provides:
About the claim 1 to fatigue prophylactic in dosing formulations containing a combination according fatigue prophylactic in taking the composition in any one of 5.

Dosage forms fatigue prophylactic in taking formulations of the present invention include capsules, tablets, powders, granules, it is not preferable is pills or drinks. In addition, additives such as a solvent, an excipient, a disintegrant, and a lubricant may be used as appropriate.

  Examples of internal preparations for preventing fatigue according to the present invention include functional foods, health foods, general foods (juices, confectionery, processed foods, etc.), dietary supplements (nutrition drinks, etc.), etc. It is preferable to use food or medicine.

  The composition for internal use for preventing fatigue and the preparation for internal use for preventing fatigue according to the present invention have an anti-fatigue effect (nourished tonic effect) for humans, which cannot be exhibited by conventional garlic or ginseng, and therefore an anti-fatigue effect for humans You can fully experience (nourishing tonic effect).

  Embodiments of the present invention will be described below. The present invention is not limited to the following.

(Adjustment of white garlic powder)
The scale of commercially available garlic (raw garlic) was dried in a temperature range of 40 ° C. to 65 ° C. by a dryer (ST-15AS manufactured by Kuroda Kogyo Co., Ltd.) to obtain dried garlic having a moisture content of 4%. The dried garlic was pulverized by a coarse pulverizer (MKCM-3, manufactured by Masuko Sangyo), and further made into a fine powder of 100 mesh pass by a high-speed pulverizer (3M-7-40 manufactured by Masuko Sangyo). This fine powder is called white garlic powder.

(Adjustment of black garlic powder)
Black garlic (manufactured by Sanken Research Institute, black garlic) obtained by fermenting commercially available garlic (raw garlic) with brown rice-derived enzyme. The black garlic scale pieces were dried and pulverized in the same manner as described above to obtain a fine powder. This fine powder is called black garlic powder S.

  Moreover, fermented black garlic (manufactured by Nissin Honey, fermented black garlic powder) produced by self-fermenting commercially available garlic (raw garlic) was pulverized in the same manner as described above to obtain a fine powder. This fine powder is called black garlic powder A.

(Preliminary examination)
In order to confirm the fatigue prevention effect (nutrition tonic effect) of garlic, the above white garlic powder and black garlic powder were orally administered to rats, and the fatigue prevention effect (nutrition tonic effect) was compared.

  First, Wister male rats (4 weeks old, body weight 165 to 183 g) were divided into 3 groups of 10 animals so that the average body weight was equal in each group. Then, white garlic powder or black garlic powder S was forcibly fed using a gastric sonde at a fixed time every day (5 g / kg of body weight per day for each group). These were not fed to the control group. All groups were fed with normal feed MF (Oriental Yeast) and fed freely with water.

  Every other day from the start of feeding, the time it takes to ride one rat on the rotor of rat exercise tester (DXP-2, manufactured by the Chinese Institute of Medical Science, DXP-2) before forced feeding, and then drop from the rotor Was measured. The result is shown in FIG.

  Compared with the control group, it was confirmed that the group fed with white garlic powder and black garlic powder S significantly prolonged exercise duration and had a fatigue prevention effect (nutrition tonic effect). In general, black garlic is said to have higher nutritional value than white garlic, but from this experiment, there was no difference in fatigue prevention effect (nourishing tonic effect) between white garlic powder and black garlic powder. .

(Adjustment of internal capsule for fatigue prevention)
The following five types of capsule preparations were manufactured, and the fatigue prevention effect (nourishing tonic effect) on humans was compared and examined.

[Comparative Example 1]
Ginseng dry extract (Indena, carrot licorice extract) 3.3% by weight as active ingredients, Thiamine sulfate 0.1% by weight, safflower salad oil 82.6%, glycerin fatty acid ester 6% by weight, beeswax 6% by weight and soybean lecithin A solution containing 2% by weight was prepared. 300 mg of the solution was filled into soft capsules coated with gelatin, glycerin and phytic acid to give a capsule preparation of Comparative Example 1.

[Comparative Example 2]
White garlic powder as active ingredient 33.4% by weight and ginseng dried extract (manufactured by Indena, carrot ginseng extract) 3.3% by weight, thiamin sulfate 0.1% by weight, safflower salad oil 49.2%, glycerin fatty acid ester 6% by weight, A solution containing 6% by weight of beeswax and 2% by weight of soybean lecithin was prepared. As in Comparative Example 1, 300 mg of the solution was filled into soft capsules to obtain a capsule preparation of Comparative Example 2.

[Example 1]
A capsule preparation was produced in the same manner as in Comparative Example 2 except that black garlic powder S was used instead of white garlic powder.

[Example 2]
A capsule preparation was produced in the same manner as in Comparative Example 2 except that black garlic powder A was used instead of white garlic powder.

[Control example]
A solution containing 0.1% by weight thiamine sulfate, 85.9% safflower salad oil, 6% by weight glycerin fatty acid ester, 6% by weight beeswax and 2% by weight soy lecithin was prepared. As in the comparative example, this solution was filled into soft capsules to obtain a capsule preparation of a control example.

(Monitoring test)
Healthy men were divided into 5 groups as a monitor, and the above 5 kinds of capsule preparations were taken orally for 3 days, 3 tablets per group. And, in a normal life, compared to the usual, “fatigue prevention effect (nourishing tonic effect)” 2 days after the start of drinking was evaluated in five levels (clear, some, some, not so much, no) . For each stage, there was a clear: 10 points, there was: 7.5 points, there was a little: 5 points, not so much: 2.5 points, not: 0 points, and the average value was calculated. The results are shown in Table 1. In addition, Comparative Example 1 and Comparative Example 2 are evaluated by a monitor of 5 persons, and the others are evaluated by 4 persons.

  First, the capsule preparation of the control example does not originally contain a component having a fatigue prevention effect (nutrition tonic effect), but half of the monitors that exhibited a placebo effect.

  Next, the capsule formulation of Comparative Example 1 containing ginseng extract as a component having a fatigue prevention effect (nutrition tonic effect) had a lower average value than the control example. In addition, the capsule preparation of Comparative Example 2 containing white garlic powder and ginseng extract had a higher average value than the control example and Comparative Example 1, but did not reach 5 points out of 10 points.

  In contrast, the capsule preparations of Example 1 and Example 2 containing black garlic S or black garlic A and ginseng extract have an average value of more than 5 points, and have a stronger fatigue prevention effect (nutrition tonic) Effect) was confirmed. In particular, in the capsule preparation of Example 2, all four monitors felt a fatigue prevention effect (nourishing tonic effect).

  In a preliminary test, there was no difference in fatigue prevention effect (nourishing tonic effect) between white garlic powder and black garlic powder. However, the internal preparation for fatigue prevention of the present invention contains black garlic and ginseng. By combining, it was confirmed that white garlic, ginseng and excellent anti-fatigue effect (nourishing tonic effect) not found in these combinations.

  The composition for internal use for preventing fatigue and the preparation for internal use for preventing fatigue of the present invention are useful in the field of health foods or pharmaceuticals.

It is a graph showing the experimental result of preliminary examination.

Claims (7)

A composition for internal use for preventing fatigue, comprising black garlic powder produced by fermenting raw garlic and ginseng as active ingredients.   The composition for internal use for fatigue prevention according to claim 1, wherein the black garlic is black garlic produced by self-fermenting raw garlic. Fatigue prevention in dose composition according to claim 1 or 2 Rei Ko ginseng is dried extract. The composition for internal use for fatigue prevention according to any one of claims 1 to 3, wherein a blending ratio between the powder of black garlic and ginseng is 20: 1 to 1: 2.   The composition for internal use for fatigue prevention according to any one of claims 1 to 4, wherein an oral dose per day is 0.3 mg / kg to 400 mg / kg of body weight.   A preparation for internal use for preventing fatigue, comprising the composition for preventing fatigue according to any one of claims 1 to 5.   The internal preparation for fatigue prevention according to claim 6, wherein the dosage form is a capsule, tablet, powder, granule, pill or drink.

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