CN108159973A - A kind of reagent chamber structure - Google Patents
A kind of reagent chamber structure Download PDFInfo
- Publication number
- CN108159973A CN108159973A CN201810017153.5A CN201810017153A CN108159973A CN 108159973 A CN108159973 A CN 108159973A CN 201810017153 A CN201810017153 A CN 201810017153A CN 108159973 A CN108159973 A CN 108159973A
- Authority
- CN
- China
- Prior art keywords
- turntable
- reagent
- chamber structure
- bottom plate
- shaking mechanism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/20—Mixing the contents of independent containers, e.g. test tubes
- B01F31/201—Holders therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/20—Mixing the contents of independent containers, e.g. test tubes
- B01F31/23—Mixing the contents of independent containers, e.g. test tubes by pivoting the containers about an axis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/70—Drives therefor, e.g. crank mechanisms
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/90—Heating or cooling systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention relates to a kind of reagent chamber structure, including:Reagent disc ontology and driving equipment, the driving equipment are used to that the shaft of reagent disc ontology to be driven to rotate;The reagent disc ontology includes:Bottom plate, disk cover, turntable, uniform shaking mechanism, the turntable, uniform shaking mechanism may be contained in the cavity between bottom plate and disk cover, the uniform shaking mechanism is set on bottom plate, the turntable is set to above uniform shaking mechanism, the driving equipment drives shaft rotation and then turntable follows rotation, and the turntable is equipped with the loading hole for placing reagent bottle and magnetic bead bottle, and the magnetic bead bottle is movably installed in loading hole, the turntable rotation, the uniform shaking mechanism synchronous drive magnetic bead bottle rotation.Reagent chamber structure provided by the invention realizes magnetic bead and shakes up, effectively save complete machine arrangement space conducive to the miniaturization of equipment, and passes through refrigeration radiating component, so that constant temperature is at 28 degrees Celsius in reagent disc, and then improves the accuracy and stability of testing result.
Description
Technical field
The present invention relates to medical instruments field more particularly to a kind of it can realize that magnetic bead shakes up and small agent bin knot
Structure.
Background technology
Chemiluminescence immune assay (chemiluminescence immunoassay, CLIA), being will be with high sensitivity
Chemical luminescent detecting technology be combined with the immune response of high specific, for various antigens, haptens, antibody, hormone,
The detection and analysis technology of enzyme, aliphatic acid, vitamin and drug etc..It is generally necessary to specific biological raw material is coated on magnetic bead,
Then luminescent solution is being added in, luminous intensity is collected to carry out quantitative analysis to detectable substance.
To ensure the activity of reagent and the stability of testing result, reagent and magnetic bead needs are protected under stationary temperature environment
It deposits and uses.Magnetic bead stands easily form precipitation for a long time, the easy concentration consistency of magnetic bead is influenced, so as to influence testing result
Accuracy and stability.To sum up, chemiluminescence equipment is required to realize the agent bin that refrigerated constant temperature and magnetic bead shake up.
Invention content
The technical solution adopted by the present invention to solve the technical problems is:A kind of reagent chamber structure, including:Reagent disc ontology
And driving equipment, the driving equipment are used to drive the intrinsic shaft rotation of reagent disc;
The reagent disc ontology includes:Bottom plate, disk cover, turntable, uniform shaking mechanism, the turntable, uniform shaking mechanism may be contained within
In cavity between bottom plate and disk cover, the uniform shaking mechanism is set on bottom plate, and the turntable is set to above uniform shaking mechanism, institute
State that driving equipment drives shaft rotation and then turntable follows rotation, the turntable is equipped with for placing reagent bottle and magnetic bead bottle
Loading hole, the magnetic bead bottle are movably installed in loading hole, and the turntable rotation, the uniform shaking mechanism synchronous drive magnetic bead bottle turns
It is dynamic.
It is further improved as the uniform shaking mechanism includes fixed gear, shakes up gear and shake up shaft, the fixed gear
It is fixedly installed on bottom plate, the magnetic bead bottle is connected by shaking up shaft with shaking up gear, described to shake up gear and fixed tooth
Wheel is mutually ratcheting.
It is further improved as the bottom plate is arranged with refrigeration radiating component.
It is further improved as the refrigeration radiating component is semiconductor refrigerating equipment.
It is further improved as the semiconductor refrigerating equipment includes Peltier briquetting, cooling piece and radiator, the Paar
Note briquetting, cooling piece, radiator are sequentially connected, and are connect at the top of the Peltier briquetting with bottom plate.
It is further improved to be enclosed with heat insulating block outside the Peltier briquetting, the cooling piece outer rim is enclosed with heat preservation
Cotton.
It is further improved as the semiconductor refrigerating equipment bottom is provided with radiator fan.
It is further improved as the reagent disc body exterior is enclosed with side insulating sponge.
It is further improved as the turntable is disposed with three circle loading hole from inside to outside.
The beneficial effects of the invention are as follows:
Reagent and magnetic bead loading are integrated in a reagent disc, are rotated in turntable by reagent chamber structure provided by the invention
While (revolution), magnetic bead bottle also rotates therewith (rotation), and without other driving equipment, it is achieved thereby that magnetic bead shakes
It is even, meanwhile, can the miniaturization of equipment be conducive to effectively save complete machine arrangement space.Also, by refrigeration radiating component, make
In reagent disc constant temperature at 2-8 degrees Celsius, and then improve the accuracy and stability of testing result.
Description of the drawings
The present invention is further described with reference to the accompanying drawings and examples.
Fig. 1 is the agent bin constructional appearance schematic diagram of the present invention;
Fig. 2 is the agent bin structure diagram of the present invention;
Fig. 3 is the turntable structure schematic diagram of reagent chamber structure of the present invention;
Fig. 4 is the refrigeration radiating component facade schematic diagram of reagent chamber structure of the present invention;
Fig. 5 is the refrigeration radiating component structure diagram of reagent chamber structure of the present invention;
Fig. 6 is the uniform shaking mechanism structure diagram of reagent chamber structure of the present invention;
Reference sign in figure:
100- reagent disc ontologies, 1- disk covers, 2- turntables, 3- driving equipments, 4- bottom plates, 5- sides heat-preservation cotton, 6- rocking evenly machines
Structure, 7- refrigeration radiating components, 8- shafts, 9- reagent bottles, 10- reagent bottles, M bottles of 11- magnetic beads, 12- Peltier briquettings, 13- heat preservations
Block, 14- heat-preservation cottons, 15- radiators, 16- radiator fans, 17- shake up shaft, and 18- shakes up gear, and 19- fixes gear, 20- systems
Cold, 21- fixed frames, 22- loading hole.
Specific embodiment
In conjunction with the accompanying drawings, the present invention is further explained in detail.These attached drawings are simplified schematic diagram, only with
Illustration illustrates the basic structure of the present invention, therefore it only shows composition related to the present invention.
In the description of invention, it is to be understood that term " " center ", " longitudinal direction ", " transverse direction ", " length ", " width ",
" thickness ", " on ", " under ", "front", "rear", "left", "right", " vertical ", " level ", " top ", " bottom " " interior ", " outer ", " up time
The orientation or position relationship of the instructions such as needle ", " counterclockwise " are based on orientation shown in the drawings or position relationship, are for only for ease of
Description rather than instruction or the device for implying meaning or element are invented and simplified in description must have specific orientation, with specific
Azimuth configuration and operation, therefore it is not intended that limitation to invention.
In addition, term " first ", " second " are only used for description purpose, and it is not intended that instruction or hint relative importance
Or the implicit quantity for indicating indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Implicitly include one or more this feature.In the description of invention, " multiple " are meant that two or more, remove
It is non-separately to have clearly specific limit.
In invention unless specifically defined or limited otherwise, the arts such as term " installation ", " connected ", " connection ", " fixation "
Language should be interpreted broadly, for example, it may be being fixedly connected or being detachably connected or be integrally connected;Can be machinery
Connection or electrical connection;It can be directly connected, can also be indirectly connected by intermediary, can be two elements
Internal connection.For the ordinary skill in the art, it can understand above-mentioned term in invention as the case may be
Concrete meaning.
As shown in Figs. 1-3, the present invention provides a kind of reagent chamber structure, including:Reagent disc ontology 100 and driving equipment 3,
The output shaft of the driving equipment 3 is connect by synchronous belt with the shaft 8 of reagent disc ontology 100, is rotated with driver, this implementation
In example, driving equipment 3 is motor;
The reagent disc ontology 100 includes:Bottom plate 4, disk cover 1, turntable 2, uniform shaking mechanism 6, the turntable 2, uniform shaking mechanism 6
It is mounted in the cavity between bottom plate 4 and disk cover 1, disk cover 1 keeps the temperature for reagent disc body interior, and the uniform shaking mechanism 6 is pacified
Loaded on bottom plate 4, the turntable 2 is set to 6 top of uniform shaking mechanism, and the drive of driving equipment 3 shaft 8 rotates and then turntable 2
Rotation is followed, the turntable 2 is equipped with the loading hole 22 for placing reagent bottle 9, reagent bottle 10 and magnetic bead bottle 11, the magnetic bead
Bottle 11 is movably installed in loading hole 22, and the turntable 2 rotates, and the 6 synchronous drive magnetic bead bottle 11 of uniform shaking mechanism rotates.This knot
When structure works, driving equipment 3 drives shaft 8 to rotate, and then turntable 2 rotates therewith, meanwhile, uniform shaking mechanism 6 drives magnetic bead bottle 11
Rotation rotation into without being individually for uniform shaking mechanism setting driving equipment, just realizes the rotation of magnetic bead bottle 11;Meanwhile this knot
It is in structure that reagent bottle and magnetic bead bottle is integrally disposed in a turntable, effective several months right integral layout spaces so that agent bin
Structure integral miniaturization.
As shown in fig. 6, it is further improved as the uniform shaking mechanism 6 turns including fixing gear 19, shaking up gear 18 and shake up
Axis 17, the fixed gear 19 are fixedly installed on bottom plate 4, and the magnetic bead bottle 11 is by shaking up shaft 17 with shaking up 18 phase of gear
Connection, and the shaft 17 that shakes up is fixed by the fixed frame 21 of 2 bottom of turntable, it is described to shake up gear 18 and fixed 19 phase of gear
It is ratcheting.In this structure, fixed gear 19 does not rotate, to be fixed on bottom plate 4 when turntable 2 rotates, due to shaking up gear 18
It is ratcheting with fixed gear 19, it shakes up gear 18 and just rotates therewith, and then magnetic bead bottle 11 rotates, realize magnetic bead in magnetic bead bottle 11 and shake
It is even.
As shown in Figure 4,5, it is further improved as the bottom plate 4 is arranged with refrigeration radiating component 7.The refrigeration radiating group
Part 7 can be multiple in 4 times installations of bottom plate, improve 4 radiating efficiency of bottom plate, and then reduce this body temperature of reagent disc.
It is further improved as the refrigeration radiating component 7 is semiconductor refrigerating equipment.Since refrigeration radiating component 7 uses
The equipment of semiconductor refrigerating technology, effectively reduces entire agent bin and refrigeration radiating component the space occupied, further reduces
The occupied space of this structure.
It is further improved as the semiconductor refrigerating equipment includes Peltier briquetting 12, cooling piece 20 and radiator 15, institute
It states Peltier briquetting 12, cooling piece 20, radiator 15 to be sequentially connected, 20 cold end of cooling piece is connect with Peltier briquetting 12, refrigeration
20 hot junction of piece is connect with radiator 15, and 12 top of Peltier briquetting is connect with bottom plate 4.Radiator 15 is reached for multiple cooling fins
Into radiator.By this radiating subassembly, can the temperature in reagent disc ontology 100 be fast and effeciently down to 2-8 DEG C.
It is further improved to be enclosed with heat insulating block 13,20 outer rim of the cooling piece package outside the Peltier briquetting 12
There is heat-preservation cotton 14.Peltier briquetting 12, cooling piece 20 are isolated from the outside world with heat-preservation cotton 12 by heat insulating block 13, so as to carry significantly
The high refrigeration radiating effect of this refrigeration radiating component 7.
It is further improved as the semiconductor refrigerating equipment bottom is provided with radiator fan 16, passes through 16 shape of radiator fan
The heat in hot junction is dissipated into strong convection.
It is further improved to be enclosed with side insulating sponge 5 outside the reagent disc ontology 100.It is kept the temperature by the side
Sponge 5 prevents reagent disc ontology 100 from carrying out heat exchange with outside air, makes its internal constant temperature.
It is further improved as the bottom plate 4 is enclosed with insulating sponge.So that 100 inside constant temperature of reagent disc ontology.
It is further improved as the turntable 2 is disposed with three circle loading hole 22 from inside to outside, is respectively used to place reagent
Bottle 9, reagent bottle 10 and magnetic bead bottle 11.
Using above-mentioned desirable embodiment according to the present invention as enlightenment, by above-mentioned description, relevant staff is complete
Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention
Property range is not limited to the content on specification, it is necessary to determine its technical scope according to right.
Claims (9)
1. a kind of reagent chamber structure, which is characterized in that including:Reagent disc ontology and driving equipment, the driving equipment are used to drive
The dynamic intrinsic shaft rotation of reagent disc;
The reagent disc ontology includes:Bottom plate, disk cover, turntable, uniform shaking mechanism, the turntable, uniform shaking mechanism may be contained within bottom plate
In cavity between disk cover, the uniform shaking mechanism is set on bottom plate, and the turntable is set to above uniform shaking mechanism, the drive
Dynamic equipment belt turn shaft rotation is moved and then turntable follows rotation, and the turntable is equipped with the loading for placing reagent bottle and magnetic bead bottle
Hole, the magnetic bead bottle are movably installed in loading hole, the turntable rotation, the uniform shaking mechanism synchronous drive magnetic bead bottle rotation.
2. reagent chamber structure according to claim 1, which is characterized in that the uniform shaking mechanism includes fixed gear, shakes up
Gear and shaft is shaken up, the fixed gear is fixedly installed on bottom plate, and the magnetic bead bottle is by shaking up shaft and shaking up gear
It is connected, it is described to shake up gear and fixed gear is mutually ratcheting.
3. reagent chamber structure according to claim 1, which is characterized in that the bottom plate is arranged with refrigeration radiating component.
4. reagent chamber structure according to claim 3, which is characterized in that the refrigeration radiating component is set for semiconductor refrigerating
It is standby.
5. reagent chamber structure according to claim 4, which is characterized in that the semiconductor refrigerating equipment includes Peltier pressure
Block, cooling piece and radiator, the Peltier briquetting, cooling piece, radiator are sequentially connected, at the top of the Peltier briquetting and bottom
Plate connects.
6. reagent chamber structure according to claim 5, which is characterized in that be enclosed with heat preservation outside the Peltier briquetting
Block, the cooling piece outer rim are enclosed with heat-preservation cotton.
7. reagent chamber structure according to claim 5 or 6, which is characterized in that the semiconductor refrigerating equipment bottom setting
There is radiator fan.
8. reagent chamber structure according to claim 1, which is characterized in that the reagent disc body exterior is enclosed with side guarantor
Warm sponge.
9. reagent chamber structure according to claim 1, which is characterized in that the turntable is disposed with three circles from inside to outside
Loading hole.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810017153.5A CN108159973A (en) | 2018-01-09 | 2018-01-09 | A kind of reagent chamber structure |
PCT/CN2018/104106 WO2019137032A1 (en) | 2018-01-09 | 2018-09-05 | Reagent chamber structure |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810017153.5A CN108159973A (en) | 2018-01-09 | 2018-01-09 | A kind of reagent chamber structure |
Publications (1)
Publication Number | Publication Date |
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CN108159973A true CN108159973A (en) | 2018-06-15 |
Family
ID=62517735
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201810017153.5A Pending CN108159973A (en) | 2018-01-09 | 2018-01-09 | A kind of reagent chamber structure |
Country Status (2)
Country | Link |
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CN (1) | CN108159973A (en) |
WO (1) | WO2019137032A1 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019137032A1 (en) * | 2018-01-09 | 2019-07-18 | 苏州长光华医生物医学工程有限公司 | Reagent chamber structure |
CN110045110A (en) * | 2019-06-03 | 2019-07-23 | 思库科技(广州)有限公司 | For dry type fluorescence/colloid gold reagent card detection temperature control compartment and temperature control method |
CN111298857A (en) * | 2019-11-29 | 2020-06-19 | 中国科学院苏州生物医学工程技术研究所 | Novel reagent refrigeration mechanism |
CN112763733A (en) * | 2020-12-28 | 2021-05-07 | 安图实验仪器(郑州)有限公司 | Reagent management device |
WO2021103783A1 (en) * | 2019-11-26 | 2021-06-03 | 苏州长光华医生物医学工程有限公司 | Chemiluminescence immunoassay analyzer and cooling circulation system thereof, and fault monitoring method |
CN113001564A (en) * | 2021-03-11 | 2021-06-22 | 中国科学院自动化研究所 | Automatic liquid distribution system and method based on industrial robot |
CN113021368A (en) * | 2021-03-11 | 2021-06-25 | 中国科学院自动化研究所 | Flat-spin overturning de-electrifying mechanism and automatic liquid distribution robot |
CN113398806A (en) * | 2020-03-17 | 2021-09-17 | 深圳迎凯生物科技有限公司 | Blending device |
CN113413801A (en) * | 2021-05-08 | 2021-09-21 | 中国辐射防护研究院 | Rolling type constant-temperature sample mixing device and using method thereof |
CN114047329A (en) * | 2021-10-19 | 2022-02-15 | 北京胡曼智造科技有限责任公司 | Reagent disk system |
CN114384061A (en) * | 2021-12-13 | 2022-04-22 | 杭州睿丽科技有限公司 | Reagent strip |
CN115267163A (en) * | 2022-06-23 | 2022-11-01 | 北京铂茵生物科技有限公司 | Chemiluminescence immunoassay kit loading, mixing and refrigerating system |
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CN206114663U (en) * | 2016-08-30 | 2017-04-19 | 重庆科斯迈生物科技有限公司 | Reagent bin system of chemiluminescence immunity analyzer |
CN206176812U (en) * | 2016-09-30 | 2017-05-17 | 苏州长光华医生物医学工程有限公司 | Refrigerating plant |
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CN205080141U (en) * | 2015-10-23 | 2016-03-09 | 深圳雷杜生命科学股份有限公司 | Magnetic bead mixing device |
CN207913668U (en) * | 2018-01-09 | 2018-09-28 | 苏州长光华医生物医学工程有限公司 | A kind of reagent chamber structure |
CN108159973A (en) * | 2018-01-09 | 2018-06-15 | 苏州长光华医生物医学工程有限公司 | A kind of reagent chamber structure |
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- 2018-01-09 CN CN201810017153.5A patent/CN108159973A/en active Pending
- 2018-09-05 WO PCT/CN2018/104106 patent/WO2019137032A1/en active Application Filing
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CN206114663U (en) * | 2016-08-30 | 2017-04-19 | 重庆科斯迈生物科技有限公司 | Reagent bin system of chemiluminescence immunity analyzer |
CN206176812U (en) * | 2016-09-30 | 2017-05-17 | 苏州长光华医生物医学工程有限公司 | Refrigerating plant |
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019137032A1 (en) * | 2018-01-09 | 2019-07-18 | 苏州长光华医生物医学工程有限公司 | Reagent chamber structure |
CN110045110A (en) * | 2019-06-03 | 2019-07-23 | 思库科技(广州)有限公司 | For dry type fluorescence/colloid gold reagent card detection temperature control compartment and temperature control method |
WO2021103783A1 (en) * | 2019-11-26 | 2021-06-03 | 苏州长光华医生物医学工程有限公司 | Chemiluminescence immunoassay analyzer and cooling circulation system thereof, and fault monitoring method |
CN111298857A (en) * | 2019-11-29 | 2020-06-19 | 中国科学院苏州生物医学工程技术研究所 | Novel reagent refrigeration mechanism |
CN113398806A (en) * | 2020-03-17 | 2021-09-17 | 深圳迎凯生物科技有限公司 | Blending device |
CN112763733A (en) * | 2020-12-28 | 2021-05-07 | 安图实验仪器(郑州)有限公司 | Reagent management device |
CN113021368A (en) * | 2021-03-11 | 2021-06-25 | 中国科学院自动化研究所 | Flat-spin overturning de-electrifying mechanism and automatic liquid distribution robot |
CN113001564A (en) * | 2021-03-11 | 2021-06-22 | 中国科学院自动化研究所 | Automatic liquid distribution system and method based on industrial robot |
CN113021368B (en) * | 2021-03-11 | 2021-12-14 | 中国科学院自动化研究所 | Flat-spin overturning de-electrifying mechanism and automatic liquid distribution robot |
CN113413801A (en) * | 2021-05-08 | 2021-09-21 | 中国辐射防护研究院 | Rolling type constant-temperature sample mixing device and using method thereof |
CN114047329A (en) * | 2021-10-19 | 2022-02-15 | 北京胡曼智造科技有限责任公司 | Reagent disk system |
CN114384061A (en) * | 2021-12-13 | 2022-04-22 | 杭州睿丽科技有限公司 | Reagent strip |
CN114384061B (en) * | 2021-12-13 | 2023-09-12 | 杭州睿丽科技有限公司 | Reagent strip |
CN115267163A (en) * | 2022-06-23 | 2022-11-01 | 北京铂茵生物科技有限公司 | Chemiluminescence immunoassay kit loading, mixing and refrigerating system |
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WO2019137032A1 (en) | 2019-07-18 |
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Application publication date: 20180615 |