CN108159973A - A kind of reagent chamber structure - Google Patents

A kind of reagent chamber structure Download PDF

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Publication number
CN108159973A
CN108159973A CN201810017153.5A CN201810017153A CN108159973A CN 108159973 A CN108159973 A CN 108159973A CN 201810017153 A CN201810017153 A CN 201810017153A CN 108159973 A CN108159973 A CN 108159973A
Authority
CN
China
Prior art keywords
turntable
reagent
chamber structure
bottom plate
shaking mechanism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810017153.5A
Other languages
Chinese (zh)
Inventor
刘建
吴冬
郭金龙
苗新利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suzhou Hybiome Biomedical Engineering Co Ltd
Original Assignee
Suzhou Hybiome Biomedical Engineering Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzhou Hybiome Biomedical Engineering Co Ltd filed Critical Suzhou Hybiome Biomedical Engineering Co Ltd
Priority to CN201810017153.5A priority Critical patent/CN108159973A/en
Publication of CN108159973A publication Critical patent/CN108159973A/en
Priority to PCT/CN2018/104106 priority patent/WO2019137032A1/en
Pending legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20Mixing the contents of independent containers, e.g. test tubes
    • B01F31/201Holders therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/20Mixing the contents of independent containers, e.g. test tubes
    • B01F31/23Mixing the contents of independent containers, e.g. test tubes by pivoting the containers about an axis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/70Drives therefor, e.g. crank mechanisms
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30Driving arrangements; Transmissions; Couplings; Brakes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/90Heating or cooling systems
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The present invention relates to a kind of reagent chamber structure, including:Reagent disc ontology and driving equipment, the driving equipment are used to that the shaft of reagent disc ontology to be driven to rotate;The reagent disc ontology includes:Bottom plate, disk cover, turntable, uniform shaking mechanism, the turntable, uniform shaking mechanism may be contained in the cavity between bottom plate and disk cover, the uniform shaking mechanism is set on bottom plate, the turntable is set to above uniform shaking mechanism, the driving equipment drives shaft rotation and then turntable follows rotation, and the turntable is equipped with the loading hole for placing reagent bottle and magnetic bead bottle, and the magnetic bead bottle is movably installed in loading hole, the turntable rotation, the uniform shaking mechanism synchronous drive magnetic bead bottle rotation.Reagent chamber structure provided by the invention realizes magnetic bead and shakes up, effectively save complete machine arrangement space conducive to the miniaturization of equipment, and passes through refrigeration radiating component, so that constant temperature is at 28 degrees Celsius in reagent disc, and then improves the accuracy and stability of testing result.

Description

A kind of reagent chamber structure
Technical field
The present invention relates to medical instruments field more particularly to a kind of it can realize that magnetic bead shakes up and small agent bin knot Structure.
Background technology
Chemiluminescence immune assay (chemiluminescence immunoassay, CLIA), being will be with high sensitivity Chemical luminescent detecting technology be combined with the immune response of high specific, for various antigens, haptens, antibody, hormone, The detection and analysis technology of enzyme, aliphatic acid, vitamin and drug etc..It is generally necessary to specific biological raw material is coated on magnetic bead, Then luminescent solution is being added in, luminous intensity is collected to carry out quantitative analysis to detectable substance.
To ensure the activity of reagent and the stability of testing result, reagent and magnetic bead needs are protected under stationary temperature environment It deposits and uses.Magnetic bead stands easily form precipitation for a long time, the easy concentration consistency of magnetic bead is influenced, so as to influence testing result Accuracy and stability.To sum up, chemiluminescence equipment is required to realize the agent bin that refrigerated constant temperature and magnetic bead shake up.
Invention content
The technical solution adopted by the present invention to solve the technical problems is:A kind of reagent chamber structure, including:Reagent disc ontology And driving equipment, the driving equipment are used to drive the intrinsic shaft rotation of reagent disc;
The reagent disc ontology includes:Bottom plate, disk cover, turntable, uniform shaking mechanism, the turntable, uniform shaking mechanism may be contained within In cavity between bottom plate and disk cover, the uniform shaking mechanism is set on bottom plate, and the turntable is set to above uniform shaking mechanism, institute State that driving equipment drives shaft rotation and then turntable follows rotation, the turntable is equipped with for placing reagent bottle and magnetic bead bottle Loading hole, the magnetic bead bottle are movably installed in loading hole, and the turntable rotation, the uniform shaking mechanism synchronous drive magnetic bead bottle turns It is dynamic.
It is further improved as the uniform shaking mechanism includes fixed gear, shakes up gear and shake up shaft, the fixed gear It is fixedly installed on bottom plate, the magnetic bead bottle is connected by shaking up shaft with shaking up gear, described to shake up gear and fixed tooth Wheel is mutually ratcheting.
It is further improved as the bottom plate is arranged with refrigeration radiating component.
It is further improved as the refrigeration radiating component is semiconductor refrigerating equipment.
It is further improved as the semiconductor refrigerating equipment includes Peltier briquetting, cooling piece and radiator, the Paar Note briquetting, cooling piece, radiator are sequentially connected, and are connect at the top of the Peltier briquetting with bottom plate.
It is further improved to be enclosed with heat insulating block outside the Peltier briquetting, the cooling piece outer rim is enclosed with heat preservation Cotton.
It is further improved as the semiconductor refrigerating equipment bottom is provided with radiator fan.
It is further improved as the reagent disc body exterior is enclosed with side insulating sponge.
It is further improved as the turntable is disposed with three circle loading hole from inside to outside.
The beneficial effects of the invention are as follows:
Reagent and magnetic bead loading are integrated in a reagent disc, are rotated in turntable by reagent chamber structure provided by the invention While (revolution), magnetic bead bottle also rotates therewith (rotation), and without other driving equipment, it is achieved thereby that magnetic bead shakes It is even, meanwhile, can the miniaturization of equipment be conducive to effectively save complete machine arrangement space.Also, by refrigeration radiating component, make In reagent disc constant temperature at 2-8 degrees Celsius, and then improve the accuracy and stability of testing result.
Description of the drawings
The present invention is further described with reference to the accompanying drawings and examples.
Fig. 1 is the agent bin constructional appearance schematic diagram of the present invention;
Fig. 2 is the agent bin structure diagram of the present invention;
Fig. 3 is the turntable structure schematic diagram of reagent chamber structure of the present invention;
Fig. 4 is the refrigeration radiating component facade schematic diagram of reagent chamber structure of the present invention;
Fig. 5 is the refrigeration radiating component structure diagram of reagent chamber structure of the present invention;
Fig. 6 is the uniform shaking mechanism structure diagram of reagent chamber structure of the present invention;
Reference sign in figure:
100- reagent disc ontologies, 1- disk covers, 2- turntables, 3- driving equipments, 4- bottom plates, 5- sides heat-preservation cotton, 6- rocking evenly machines Structure, 7- refrigeration radiating components, 8- shafts, 9- reagent bottles, 10- reagent bottles, M bottles of 11- magnetic beads, 12- Peltier briquettings, 13- heat preservations Block, 14- heat-preservation cottons, 15- radiators, 16- radiator fans, 17- shake up shaft, and 18- shakes up gear, and 19- fixes gear, 20- systems Cold, 21- fixed frames, 22- loading hole.
Specific embodiment
In conjunction with the accompanying drawings, the present invention is further explained in detail.These attached drawings are simplified schematic diagram, only with Illustration illustrates the basic structure of the present invention, therefore it only shows composition related to the present invention.
In the description of invention, it is to be understood that term " " center ", " longitudinal direction ", " transverse direction ", " length ", " width ", " thickness ", " on ", " under ", "front", "rear", "left", "right", " vertical ", " level ", " top ", " bottom " " interior ", " outer ", " up time The orientation or position relationship of the instructions such as needle ", " counterclockwise " are based on orientation shown in the drawings or position relationship, are for only for ease of Description rather than instruction or the device for implying meaning or element are invented and simplified in description must have specific orientation, with specific Azimuth configuration and operation, therefore it is not intended that limitation to invention.
In addition, term " first ", " second " are only used for description purpose, and it is not intended that instruction or hint relative importance Or the implicit quantity for indicating indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or Implicitly include one or more this feature.In the description of invention, " multiple " are meant that two or more, remove It is non-separately to have clearly specific limit.
In invention unless specifically defined or limited otherwise, the arts such as term " installation ", " connected ", " connection ", " fixation " Language should be interpreted broadly, for example, it may be being fixedly connected or being detachably connected or be integrally connected;Can be machinery Connection or electrical connection;It can be directly connected, can also be indirectly connected by intermediary, can be two elements Internal connection.For the ordinary skill in the art, it can understand above-mentioned term in invention as the case may be Concrete meaning.
As shown in Figs. 1-3, the present invention provides a kind of reagent chamber structure, including:Reagent disc ontology 100 and driving equipment 3, The output shaft of the driving equipment 3 is connect by synchronous belt with the shaft 8 of reagent disc ontology 100, is rotated with driver, this implementation In example, driving equipment 3 is motor;
The reagent disc ontology 100 includes:Bottom plate 4, disk cover 1, turntable 2, uniform shaking mechanism 6, the turntable 2, uniform shaking mechanism 6 It is mounted in the cavity between bottom plate 4 and disk cover 1, disk cover 1 keeps the temperature for reagent disc body interior, and the uniform shaking mechanism 6 is pacified Loaded on bottom plate 4, the turntable 2 is set to 6 top of uniform shaking mechanism, and the drive of driving equipment 3 shaft 8 rotates and then turntable 2 Rotation is followed, the turntable 2 is equipped with the loading hole 22 for placing reagent bottle 9, reagent bottle 10 and magnetic bead bottle 11, the magnetic bead Bottle 11 is movably installed in loading hole 22, and the turntable 2 rotates, and the 6 synchronous drive magnetic bead bottle 11 of uniform shaking mechanism rotates.This knot When structure works, driving equipment 3 drives shaft 8 to rotate, and then turntable 2 rotates therewith, meanwhile, uniform shaking mechanism 6 drives magnetic bead bottle 11 Rotation rotation into without being individually for uniform shaking mechanism setting driving equipment, just realizes the rotation of magnetic bead bottle 11;Meanwhile this knot It is in structure that reagent bottle and magnetic bead bottle is integrally disposed in a turntable, effective several months right integral layout spaces so that agent bin Structure integral miniaturization.
As shown in fig. 6, it is further improved as the uniform shaking mechanism 6 turns including fixing gear 19, shaking up gear 18 and shake up Axis 17, the fixed gear 19 are fixedly installed on bottom plate 4, and the magnetic bead bottle 11 is by shaking up shaft 17 with shaking up 18 phase of gear Connection, and the shaft 17 that shakes up is fixed by the fixed frame 21 of 2 bottom of turntable, it is described to shake up gear 18 and fixed 19 phase of gear It is ratcheting.In this structure, fixed gear 19 does not rotate, to be fixed on bottom plate 4 when turntable 2 rotates, due to shaking up gear 18 It is ratcheting with fixed gear 19, it shakes up gear 18 and just rotates therewith, and then magnetic bead bottle 11 rotates, realize magnetic bead in magnetic bead bottle 11 and shake It is even.
As shown in Figure 4,5, it is further improved as the bottom plate 4 is arranged with refrigeration radiating component 7.The refrigeration radiating group Part 7 can be multiple in 4 times installations of bottom plate, improve 4 radiating efficiency of bottom plate, and then reduce this body temperature of reagent disc.
It is further improved as the refrigeration radiating component 7 is semiconductor refrigerating equipment.Since refrigeration radiating component 7 uses The equipment of semiconductor refrigerating technology, effectively reduces entire agent bin and refrigeration radiating component the space occupied, further reduces The occupied space of this structure.
It is further improved as the semiconductor refrigerating equipment includes Peltier briquetting 12, cooling piece 20 and radiator 15, institute It states Peltier briquetting 12, cooling piece 20, radiator 15 to be sequentially connected, 20 cold end of cooling piece is connect with Peltier briquetting 12, refrigeration 20 hot junction of piece is connect with radiator 15, and 12 top of Peltier briquetting is connect with bottom plate 4.Radiator 15 is reached for multiple cooling fins Into radiator.By this radiating subassembly, can the temperature in reagent disc ontology 100 be fast and effeciently down to 2-8 DEG C.
It is further improved to be enclosed with heat insulating block 13,20 outer rim of the cooling piece package outside the Peltier briquetting 12 There is heat-preservation cotton 14.Peltier briquetting 12, cooling piece 20 are isolated from the outside world with heat-preservation cotton 12 by heat insulating block 13, so as to carry significantly The high refrigeration radiating effect of this refrigeration radiating component 7.
It is further improved as the semiconductor refrigerating equipment bottom is provided with radiator fan 16, passes through 16 shape of radiator fan The heat in hot junction is dissipated into strong convection.
It is further improved to be enclosed with side insulating sponge 5 outside the reagent disc ontology 100.It is kept the temperature by the side Sponge 5 prevents reagent disc ontology 100 from carrying out heat exchange with outside air, makes its internal constant temperature.
It is further improved as the bottom plate 4 is enclosed with insulating sponge.So that 100 inside constant temperature of reagent disc ontology.
It is further improved as the turntable 2 is disposed with three circle loading hole 22 from inside to outside, is respectively used to place reagent Bottle 9, reagent bottle 10 and magnetic bead bottle 11.
Using above-mentioned desirable embodiment according to the present invention as enlightenment, by above-mentioned description, relevant staff is complete Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention Property range is not limited to the content on specification, it is necessary to determine its technical scope according to right.

Claims (9)

1. a kind of reagent chamber structure, which is characterized in that including:Reagent disc ontology and driving equipment, the driving equipment are used to drive The dynamic intrinsic shaft rotation of reagent disc;
The reagent disc ontology includes:Bottom plate, disk cover, turntable, uniform shaking mechanism, the turntable, uniform shaking mechanism may be contained within bottom plate In cavity between disk cover, the uniform shaking mechanism is set on bottom plate, and the turntable is set to above uniform shaking mechanism, the drive Dynamic equipment belt turn shaft rotation is moved and then turntable follows rotation, and the turntable is equipped with the loading for placing reagent bottle and magnetic bead bottle Hole, the magnetic bead bottle are movably installed in loading hole, the turntable rotation, the uniform shaking mechanism synchronous drive magnetic bead bottle rotation.
2. reagent chamber structure according to claim 1, which is characterized in that the uniform shaking mechanism includes fixed gear, shakes up Gear and shaft is shaken up, the fixed gear is fixedly installed on bottom plate, and the magnetic bead bottle is by shaking up shaft and shaking up gear It is connected, it is described to shake up gear and fixed gear is mutually ratcheting.
3. reagent chamber structure according to claim 1, which is characterized in that the bottom plate is arranged with refrigeration radiating component.
4. reagent chamber structure according to claim 3, which is characterized in that the refrigeration radiating component is set for semiconductor refrigerating It is standby.
5. reagent chamber structure according to claim 4, which is characterized in that the semiconductor refrigerating equipment includes Peltier pressure Block, cooling piece and radiator, the Peltier briquetting, cooling piece, radiator are sequentially connected, at the top of the Peltier briquetting and bottom Plate connects.
6. reagent chamber structure according to claim 5, which is characterized in that be enclosed with heat preservation outside the Peltier briquetting Block, the cooling piece outer rim are enclosed with heat-preservation cotton.
7. reagent chamber structure according to claim 5 or 6, which is characterized in that the semiconductor refrigerating equipment bottom setting There is radiator fan.
8. reagent chamber structure according to claim 1, which is characterized in that the reagent disc body exterior is enclosed with side guarantor Warm sponge.
9. reagent chamber structure according to claim 1, which is characterized in that the turntable is disposed with three circles from inside to outside Loading hole.
CN201810017153.5A 2018-01-09 2018-01-09 A kind of reagent chamber structure Pending CN108159973A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201810017153.5A CN108159973A (en) 2018-01-09 2018-01-09 A kind of reagent chamber structure
PCT/CN2018/104106 WO2019137032A1 (en) 2018-01-09 2018-09-05 Reagent chamber structure

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810017153.5A CN108159973A (en) 2018-01-09 2018-01-09 A kind of reagent chamber structure

Publications (1)

Publication Number Publication Date
CN108159973A true CN108159973A (en) 2018-06-15

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WO (1) WO2019137032A1 (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019137032A1 (en) * 2018-01-09 2019-07-18 苏州长光华医生物医学工程有限公司 Reagent chamber structure
CN110045110A (en) * 2019-06-03 2019-07-23 思库科技(广州)有限公司 For dry type fluorescence/colloid gold reagent card detection temperature control compartment and temperature control method
CN111298857A (en) * 2019-11-29 2020-06-19 中国科学院苏州生物医学工程技术研究所 Novel reagent refrigeration mechanism
CN112763733A (en) * 2020-12-28 2021-05-07 安图实验仪器(郑州)有限公司 Reagent management device
WO2021103783A1 (en) * 2019-11-26 2021-06-03 苏州长光华医生物医学工程有限公司 Chemiluminescence immunoassay analyzer and cooling circulation system thereof, and fault monitoring method
CN113001564A (en) * 2021-03-11 2021-06-22 中国科学院自动化研究所 Automatic liquid distribution system and method based on industrial robot
CN113021368A (en) * 2021-03-11 2021-06-25 中国科学院自动化研究所 Flat-spin overturning de-electrifying mechanism and automatic liquid distribution robot
CN113398806A (en) * 2020-03-17 2021-09-17 深圳迎凯生物科技有限公司 Blending device
CN113413801A (en) * 2021-05-08 2021-09-21 中国辐射防护研究院 Rolling type constant-temperature sample mixing device and using method thereof
CN114047329A (en) * 2021-10-19 2022-02-15 北京胡曼智造科技有限责任公司 Reagent disk system
CN114384061A (en) * 2021-12-13 2022-04-22 杭州睿丽科技有限公司 Reagent strip
CN115267163A (en) * 2022-06-23 2022-11-01 北京铂茵生物科技有限公司 Chemiluminescence immunoassay kit loading, mixing and refrigerating system

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CN112791642B (en) * 2021-01-11 2022-06-28 齐鲁工业大学 Medicine liquid shaking-up machine
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CN108159973A (en) * 2018-01-09 2018-06-15 苏州长光华医生物医学工程有限公司 A kind of reagent chamber structure
CN207913668U (en) * 2018-01-09 2018-09-28 苏州长光华医生物医学工程有限公司 A kind of reagent chamber structure

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019137032A1 (en) * 2018-01-09 2019-07-18 苏州长光华医生物医学工程有限公司 Reagent chamber structure
CN110045110A (en) * 2019-06-03 2019-07-23 思库科技(广州)有限公司 For dry type fluorescence/colloid gold reagent card detection temperature control compartment and temperature control method
WO2021103783A1 (en) * 2019-11-26 2021-06-03 苏州长光华医生物医学工程有限公司 Chemiluminescence immunoassay analyzer and cooling circulation system thereof, and fault monitoring method
CN111298857A (en) * 2019-11-29 2020-06-19 中国科学院苏州生物医学工程技术研究所 Novel reagent refrigeration mechanism
CN113398806A (en) * 2020-03-17 2021-09-17 深圳迎凯生物科技有限公司 Blending device
CN112763733A (en) * 2020-12-28 2021-05-07 安图实验仪器(郑州)有限公司 Reagent management device
CN113021368A (en) * 2021-03-11 2021-06-25 中国科学院自动化研究所 Flat-spin overturning de-electrifying mechanism and automatic liquid distribution robot
CN113001564A (en) * 2021-03-11 2021-06-22 中国科学院自动化研究所 Automatic liquid distribution system and method based on industrial robot
CN113021368B (en) * 2021-03-11 2021-12-14 中国科学院自动化研究所 Flat-spin overturning de-electrifying mechanism and automatic liquid distribution robot
CN113413801A (en) * 2021-05-08 2021-09-21 中国辐射防护研究院 Rolling type constant-temperature sample mixing device and using method thereof
CN114047329A (en) * 2021-10-19 2022-02-15 北京胡曼智造科技有限责任公司 Reagent disk system
CN114384061A (en) * 2021-12-13 2022-04-22 杭州睿丽科技有限公司 Reagent strip
CN114384061B (en) * 2021-12-13 2023-09-12 杭州睿丽科技有限公司 Reagent strip
CN115267163A (en) * 2022-06-23 2022-11-01 北京铂茵生物科技有限公司 Chemiluminescence immunoassay kit loading, mixing and refrigerating system

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Application publication date: 20180615