CN111298857A - Novel reagent refrigeration mechanism - Google Patents

Novel reagent refrigeration mechanism Download PDF

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Publication number
CN111298857A
CN111298857A CN201911204637.1A CN201911204637A CN111298857A CN 111298857 A CN111298857 A CN 111298857A CN 201911204637 A CN201911204637 A CN 201911204637A CN 111298857 A CN111298857 A CN 111298857A
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CN
China
Prior art keywords
reagent
refrigeration
assembly
gear
plate
Prior art date
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Pending
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CN201911204637.1A
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Chinese (zh)
Inventor
赵义龙
王弼陡
罗刚银
黄杰
沈苑
宋明轩
赵勇
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Suzhou Institute of Biomedical Engineering and Technology of CAS
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Suzhou Institute of Biomedical Engineering and Technology of CAS
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Application filed by Suzhou Institute of Biomedical Engineering and Technology of CAS filed Critical Suzhou Institute of Biomedical Engineering and Technology of CAS
Priority to CN201911204637.1A priority Critical patent/CN111298857A/en
Publication of CN111298857A publication Critical patent/CN111298857A/en
Pending legal-status Critical Current

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00Mixers with rotating receptacles
    • B01F29/80Mixers with rotating receptacles rotating about a substantially vertical axis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45Magnetic mixers; Mixers with magnetically driven stirrers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00Supporting devices; Holding devices

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention discloses a novel reagent refrigeration mechanism, which comprises a reagent bin, a rotating assembly, a driving assembly and a refrigeration assembly, wherein the reagent bin is provided with a storage chamber; the rotating assembly comprises a main rotating piece and a secondary rotating piece; the main rotating part is used for driving the reagent box placed in the reagent bin to revolve under the driving of the driving component; the secondary rotating piece is arranged on the main rotating piece, and the secondary rotating piece revolves along with the main rotating piece and also rotates, so that at least one reagent bottle on a reagent box placed in the reagent bin is driven to rotate relative to the reagent box through a stirring paddle arranged on the secondary rotating piece. The reagent box has the advantages that the refrigeration component provides a refrigeration function for the reagent box, the refrigeration component has a good refrigeration effect, the reagent box in the reagent box rotates through the rotating component, and simultaneously, the reagent bottles on the reagent box can also rotate relative to the reagent box, so that the reagents in the reagent box can be fully mixed, and the refrigeration, mixing and scheduling functions of the reagents are realized.

Description

Novel reagent refrigeration mechanism
Technical Field
The invention relates to the field of biochemical detection equipment, in particular to a novel reagent refrigerating mechanism.
Background
In many automated testing instruments, such as chemiluminescent testing instruments, specialized reagent coolers are required to provide reagent refrigeration, blending, and scheduling functions. The reagent put into the reagent bin needs to be refrigerated, the reagent can be transferred to a designated position, and meanwhile, part of the reagent (such as magnetic bead liquid, including buffer solution and magnetic beads, whether the magnetic beads and the buffer solution are uniformly mixed or not plays an important role in a detection result, and the magnetic beads are settled to the bottom after the magnetic bead liquid is static for a long time, so that the magnetic bead liquid needs to be uniformly mixed before the magnetic bead liquid is used). The current reagent refrigerating device usually adopts special refrigerating equipment for realizing the refrigerating function, and usually adopts a relevant mechanical mechanism to drive the reagent kit to rotate for realizing the blending and dispatching functions. However, the existing reagent refrigerating device has the problems of insufficient mixing, poor refrigerating effect, inconvenience in taking and placing the reagent kit in the reagent refrigerating device and the like, so a more reliable scheme is needed at present.
Disclosure of Invention
The technical problem to be solved by the present invention is to provide a novel reagent refrigeration mechanism for overcoming the above-mentioned shortcomings in the prior art.
In order to solve the technical problems, the invention adopts the technical scheme that: a novel reagent refrigeration mechanism comprises a reagent bin, a rotating assembly, a driving assembly and a refrigeration assembly;
the driving assembly is used for improving the driving force for the rotating assembly;
the rotating assembly is arranged inside the reagent bin and comprises a main rotating piece and a secondary rotating piece; the main rotating part is used for driving the reagent box placed in the reagent bin to revolve under the driving of the driving component; the secondary rotating piece is arranged on the main rotating piece, and the secondary rotating piece revolves along with the main rotating piece and also rotates automatically, so that at least one reagent bottle on a reagent box placed in the reagent bin is driven to rotate relative to the reagent box by a stirring paddle arranged on the secondary rotating piece;
the refrigeration assembly is used for providing a refrigeration function for the reagent bin.
Preferably, the reagent cabin comprises a bottom plate, a heat preservation cover arranged on the bottom plate and a cover plate arranged on the heat preservation cover;
a guide groove is formed in the side wall of the upper end of the heat-insulating cover, and a guide protruding block inserted into the guide groove is arranged at the bottom of the cover plate.
Preferably, the window has been seted up to the lateral part of heat preservation cover, be provided with antifog glass assembly on the window, antifog glass assembly is including connecting clamp plate on the lateral wall of heat preservation cover and range upon range of the setting in proper order and be in first glass piece, annular heating plate and second glass piece between the lateral wall of clamp plate and heat preservation cover.
Preferably, the reagent box further comprises a mounting plate, the reagent box is arranged on the mounting plate, and the refrigeration assembly is arranged at the bottom of the mounting plate;
the main rotating part comprises a large gear which is rotatably arranged on the bottom plate and a reagent coded disc which is fixedly connected on the large gear, and a fixed gear is fixedly connected on the bottom plate; the large gear, the reagent coded disc and the fixed gear are coaxially arranged;
the reagent code disc is provided with a mounting hole in the middle, and the fixed gear is fixedly connected to the bottom plate through a fixed shaft penetrating through the mounting hole.
Preferably, the secondary rotating member comprises a plurality of pinion gears which are arranged on the reagent code disc in a ring array in a rotatable manner and meshed with the fixed gear, and the stirring paddle fixedly connected to the pinion gears, and the stirring paddle comprises two stirring columns symmetrically arranged on the pinion gears.
Preferably, the driving assembly comprises a motor arranged on the mounting plate, a driving gear connected with an output shaft of the motor, and a gear belt for driving and connecting the driving gear and the gearwheel; when the driving gear drives the gear wheel and the reagent code disc to revolve through the gear belt, the pinion on the reagent code disc rotates under the meshing action of the fixed gear.
Preferably, a pillar is arranged on the fixed gear, a magnet is arranged on the pillar, and an iron block used for attracting the magnet is arranged at the bottom of the cover plate.
Preferably, a plurality of positioning grooves are uniformly arranged on the periphery of the reagent coded disc at intervals, and positioning blocking sheets are further arranged on the peripheral edge of the reagent coded disc; the bottom plate is provided with a first optical coupler and a second optical coupler which are used for being respectively matched with the positioning groove and the positioning baffle.
Preferably, a plurality of mounting blocks are arranged on the bottom plate in an annular array, and a mounting groove for placing the reagent kit is formed between every two mounting blocks;
two installation fixture blocks are symmetrically arranged on two inner walls at the bottom of the opening at the inner side of the installation groove, and limiting clamping grooves are formed in the inner walls at the two sides of the middle part of the installation groove.
Preferably, the bottom of a reagent bottle rotatably arranged on the reagent kit is connected with a stirring sheet, after the reagent kit is arranged in the mounting groove, the two stirring columns are respectively arranged at two sides of the stirring sheet, and when the two stirring columns rotate, the reagent bottle can be driven to rotate in the reagent kit through the stirring sheet;
the kit is characterized in that bulges are symmetrically arranged on the outer walls of two sides of the upper part of the kit, two fixing clamping grooves are symmetrically arranged on the outer walls of two sides of the bottom of the kit, the kit is arranged in the mounting groove, the mounting clamping blocks are clamped in the fixing clamping grooves, and the bulges are clamped in the fixing clamping grooves.
The invention has the beneficial effects that: the novel reagent refrigeration mechanism provides a refrigeration function for the reagent bin through the refrigeration assembly, has a good refrigeration effect, enables the reagent box in the reagent bin to rotate through the rotation assembly, enables the reagent bottles on the reagent box to rotate relative to the reagent box, and ensures that reagents in the reagent box are fully mixed, so that the refrigeration, mixing and scheduling functions of the reagents are realized;
according to the invention, by arranging the anti-fog glass assembly, water fog can be prevented from being generated on the window glass, and the code scanning function is prevented from being influenced;
according to the invention, the guide mechanism and the magnetic mechanism are arranged on the cover plate and the heat-insulating cover, so that the cover plate can be conveniently closed, and the cover plate can be ensured to be closed in place;
the reagent box can be stably arranged on the reagent code disc to realize the functions of scheduling and uniformly mixing, and the reagent box is convenient to take and place.
Drawings
FIG. 1 is a schematic diagram of the novel reagent refrigeration mechanism of the present invention;
FIG. 2 is a schematic structural diagram of the novel reagent refrigerating mechanism of the present invention after the heat preservation cotton is removed;
FIG. 3 is a schematic cross-sectional view in the thickness direction of the antifogging glass assembly of the present invention;
FIG. 4 is a schematic diagram of the internal structure of the novel reagent refrigeration mechanism of the present invention;
FIG. 5 is a schematic view of another perspective of the interior of the novel reagent refrigeration mechanism of the present invention;
FIG. 6 is a schematic view of the construction of the rotating assembly and the drive assembly of the present invention;
FIG. 7 is a schematic structural diagram of a cover plate according to the present invention;
FIG. 8 is a schematic structural view of the heat retention cover of the present invention;
FIG. 9 is a schematic cross-sectional view of the novel reagent refrigeration mechanism of the present invention;
FIG. 10 is a schematic structural view of a kit of the present invention;
FIG. 11 is a schematic view of the structure of the bottom of the kit of the present invention;
FIG. 12 is a schematic sectional structure view of the kit of the present invention.
Description of reference numerals:
1-reagent bin; 10-a base plate; 11-a heat preservation cover; 12-a cover plate; 13-heat preservation cotton; 14-a guide groove; 15-a guide projection; 16-a sealing ring; 17-a window; 18-antifogging glass assembly; 19-bar code gun; 100-a first optocoupler; 101-a second optocoupler; 120-iron block; 121 — an annular flange; 180-pressing plate; 181 — a first glass sheet; 182-annular heating plate; 183-second glass sheet;
2-main rotating member; 20-a bull gear; 21-reagent code disc; 22-fixed gear; 23-a pillar; 24-a magnet; 210-a positioning groove; 211-positioning block piece; 212-a mounting block; 213-mounting groove; 214, mounting a fixture block; 215-limiting clamping groove;
3-secondary rotation member; 30-pinion gear; 31-a stirring paddle; 32-stirring column;
4-a drive assembly; 40, a motor; 41-a drive gear; 42-a gear belt;
5-a refrigeration component;
6, mounting a plate;
7-kit; 70-reagent bottle; 71-stirring sheet; 72-bump; 73-fixed card slot.
Detailed Description
The present invention is further described in detail below with reference to examples so that those skilled in the art can practice the invention with reference to the description.
It will be understood that terms such as "having," "including," and "comprising," as used herein, do not preclude the presence or addition of one or more other elements or groups thereof.
As shown in fig. 1-12, the novel reagent refrigerating mechanism of the present embodiment includes a reagent chamber 1, a rotating assembly, a driving assembly 4, and a refrigerating assembly 5;
the driving assembly 4 is used for improving the driving force for the rotating assembly;
the rotating assembly is arranged inside the reagent cabin 1 and comprises a main rotating part 2 and a secondary rotating part 3; the main rotating part 2 is used for driving the reagent box 7 placed in the reagent bin 1 to revolve under the driving of the driving component 4; the secondary rotating member 3 is arranged on the main rotating member 2, the secondary rotating member 3 revolves along with the main rotating member 2 and also rotates, so that at least one reagent bottle 70 on the reagent box 7 placed in the reagent bin 1 is driven to rotate relative to the reagent box 7 by a stirring paddle 31 arranged on the secondary rotating member 3;
the refrigerating assembly 5 is used for providing a refrigerating function for the reagent cabin 1, and the refrigerating assembly 5 can be selected from conventional products. In one embodiment, the refrigeration component 5 comprises a peltier element and a fan, a heat conduction component is arranged between the peltier element and the reagent chamber 1, the reagent chamber 1 is refrigerated through the cold end of the peltier element, and the hot end of the peltier element is rapidly cooled through the fan.
The novel reagent refrigeration mechanism can be mainly applied to automatic detection equipment which needs to provide functions of refrigerating, uniformly mixing and scheduling reagents, such as a chemiluminescence detector. A plurality of reagent boxes 7 storing reagents (at least one reagent bottle 70 capable of freely rotating relative to the reagent boxes 7 is arranged on each reagent box 7) are placed in a reagent refrigerating mechanism, and then are refrigerated through a refrigerating assembly 5; the main rotating piece 2 drives the plurality of reagent boxes 7 to rotate, and the reagent boxes 7 are rotated to the designated positions to realize scheduling; the reagent bottle 70 is driven to rotate by the secondary rotating part 3, so that the uniform mixing function is realized.
Specifically, in one embodiment, the reagent chamber 1 includes a bottom plate 10, a heat-insulating cover 11 disposed on the bottom plate 10, and a cover plate 12 disposed on the heat-insulating cover 11; a guide groove 14 is formed in the side wall of the upper end of the heat preservation cover 11, and a guide convex block 15 inserted into the guide groove 14 is arranged at the bottom of the cover plate 12. The bottom of the cover plate 12 is also provided with an annular flange 121. When the cover plate 12 is covered on the heat-insulating cover 11, the guide lug 15 is inserted into the guide groove 14 to realize guiding, so that the cover plate 12 can be smoothly covered on the heat-insulating cover 11; the annular flange 121 is positioned inside the opening at the upper part of the heat-insulating cover 11, and can improve the sealing effect. Furthermore, an annular groove is arranged between the bottom of the cover plate 12 and the heat preservation cover 11, and a sealing ring 16 is arranged in the annular groove. Furthermore, the outer side of the heat-insulating cover 11 is provided with heat-insulating cotton 13 to improve the heat-insulating effect and ensure a better refrigerating effect.
Wherein, the lateral part of the heat preservation cover 11 is provided with a window 17, and the window 17 is provided with an antifogging glass assembly 18. The side of the window 17 is provided with a bar code gun 19, and a bar code at the side of the reagent box 7 is scanned by the bar code gun 19 to realize a scanning function so as to detect and record the reagent box 7 in the reagent bin 1. In the preferred embodiment, the anti-fog glass assembly 18 comprises a press plate 180 attached to the side wall of the insulated enclosure 11 and a first glass sheet 181, a ring-shaped heating sheet 182 and a second glass sheet 183 laminated in this order between the press plate 180 and the side wall of the insulated enclosure 11. The heat insulation cotton 13 is arranged between the first glass sheet 181 and the pressing plate 180 and between the second glass sheet 183 and the side wall of the heat insulation cover 11. Because the temperature in the heat preservation cover 11 is lower than the outside, the conventional single-layer glass is adopted, condensed water is easily formed on the glass by the outside air, so that fog is generated on the glass, and the scanning of the kit 7 is influenced. In this embodiment, the annular heating sheet 182 is a flexible heating sheet, and the first glass sheet 181 and the second glass sheet 183 are heated by the flexible heating sheet, so that a temperature difference between the first glass sheet 181 contacting with the outside air and the second glass sheet 183 contacting with the first glass sheet 181 is substantially not generated, and thus the outside air does not generate condensed water on the first glass sheet 181 any more, and an anti-fog function is realized.
The novel reagent refrigeration mechanism further comprises a mounting plate 6, the reagent bin 1 is arranged on the mounting plate 6, and the refrigeration assembly 5 is arranged at the bottom of the mounting plate 6.
In one embodiment, the main rotating member 2 comprises a gearwheel 20 rotatably disposed on the bottom plate 10, a reagent code disc 21 fixedly connected to the gearwheel 20, and a fixed gear 22 fixedly connected to the bottom plate 10; the large gear 20, the reagent code disc 21 and the fixed gear 22 are coaxially arranged; the reagent code disc 21 is provided with a mounting hole (not shown) in the middle, and the fixed gear 22 is fixedly connected to the bottom plate 10 through a fixed shaft passing through the mounting hole. The secondary rotating member 3 comprises a plurality of pinions 30 which are rotatably arranged on the reagent code disc 21 in an annular array and are meshed with the fixed gear 22, and a stirring paddle 31 fixedly connected to the pinions 30, wherein the stirring paddle 31 comprises two stirring columns 32 which are symmetrically arranged on the pinions 30.
Further, the driving assembly 4 comprises a motor 40 arranged on the mounting plate 6, a driving gear 41 connected with an output shaft of the motor 40, and a gear belt 42 for driving and connecting the driving gear 41 and the large gear 20; when the large gear 20 and the reagent code disk 21 are revolved by the driving gear 41 via the gear belt 42, the small gear 30 on the reagent code disk 21 rotates simultaneously by the meshing action of the fixed gear 22.
Further, a support 23 is arranged on the fixed gear 22, a magnet 24 is arranged on the support 23, and an iron block 120 for attracting the magnet 24 is arranged at the bottom of the cover plate 12. After the cover plate 12 is covered on the heat preservation cover 11, the magnet 24 is attracted with the iron block 120, so that the cover plate 12 is ensured to be covered in place, and the covering stability is improved. In a further embodiment, a conventional position switch may be provided on the heat-retaining cover 11 to detect whether the cover 12 is closed.
Furthermore, a plurality of positioning grooves 210 are uniformly arranged on the periphery of the reagent code disc 21 at intervals, and positioning blocking sheets 211 are arranged on the peripheral edge of the reagent code disc 21; the base plate 10 is provided with a first optical coupler 100 and a second optical coupler 101 which are respectively matched with the positioning groove 210 and the positioning baffle 211. The number of the positioning grooves 210 corresponds to the number of the pinions 30. One optical coupler is used as an original point detection optical coupler, and the other optical coupler is used as a position detection optical coupler. For example, in the present embodiment, both the two optocouplers are reflective optocouplers, the first optocoupler 100 serves as an origin detection optocoupler, and when the reagent code disc 21 rotates to a position where the positioning baffle 211 reaches above the first optocoupler 100, a trigger signal indicates that the reagent code disc 21 reaches the origin; the second optical coupler 101 is used as a position detection optical coupler, when the reagent coded disc 21 rotates to one of the positioning grooves 210 to reach the upper part of the second optical coupler 101, the small gear 30 (namely the reagent kit 7 thereon) corresponding to the position reaches the working position, and the next reagent kit 7 reaches the position, a signal is triggered again, so that the reagent disc can or does not rotate by a certain angle to realize the positioning function. A set of mutually corresponding detent recesses 210 and the pinion 30 are on the same radius line.
In a further preferred embodiment, a plurality of mounting blocks 212 are arranged on the bottom plate 10 in an annular array, and a mounting groove 213 for placing the reagent kit 7 is formed between every two mounting blocks 212; two mounting blocks 214 are symmetrically arranged on two inner walls at the bottom of the opening of the inner side of the mounting groove 213, and limiting clamping grooves 215 are arranged on the inner walls at two sides of the middle part of the mounting groove 213. The reagent box 7 is provided with at least one rotatable reagent bottle 70, in the embodiment, the reagent box 7 is provided with two reagent bottles 70, one of the two reagent bottles 70 is fixed, the other reagent bottle 70 is rotatable, and the bottom of the reagent bottle 70 which is rotatably arranged on the reagent box 7 is connected with a stirring sheet 71; the reagent that needs the mixing is stored in rotatable reagent bottle 70, like the magnetic bead liquid (the magnetic bead liquid includes buffer solution and magnetic bead, whether magnetic bead and buffer mix evenly plays important role to the testing result, because the long-time back of quiescence of magnetic bead liquid, the magnetic bead can sink to the bottom, so need the mixing magnetic bead liquid before using the magnetic bead liquid). After the reagent box 7 is arranged in the mounting groove 213, the two stirring columns 32 are respectively arranged at two sides of the stirring sheet 71, and when the two stirring columns 32 rotate, the reagent bottle 70 can be driven by the stirring sheet 71 to rotate in the reagent box 7, so that the reagents can be fully and uniformly mixed;
the outer walls of two sides of the upper part of the reagent kit 7 are symmetrically provided with protrusions 72, the outer walls of two sides of the bottom of the reagent kit 7 are symmetrically provided with two fixing clamping grooves 73, after the reagent kit 7 is arranged in the installation groove 213, the installation clamping blocks 214 are clamped in the fixing clamping grooves 73, and the protrusions 72 are clamped in the fixing clamping grooves 73. The reagent box 7 can be stably arranged on the reagent code disc 21 and is convenient to take and place.
The working principle of the novel reagent refrigerating mechanism is as follows:
the reagent box 7 is arranged in the mounting groove 213 on the reagent code disc 21 from top to bottom, and the bulge 72 on the reagent box 7 is clamped into the fixed clamping groove 73 after passing through the inner wall of the upper part of the fixed clamping groove 73, so that the up-and-down movement of the reagent box 7 is limited; the mounting fixture block 214 on the inner side of the mounting groove 213 is clamped in the limiting fixture groove 215 to limit the horizontal movement of the reagent kit 7, so that the reagent kit 7 is stably arranged in the mounting groove 213, and the stirring sheet 71 at the bottom of the rotatable reagent bottle 70 is just positioned between the two stirring posts 32 on the pinion 30;
the driving gear 41 drives the large gear 20 and the reagent code disc 21 to revolve through the gear belt 42 so as to transfer the reagent box 7 on the reagent code disc 21 to a specified position, and when the reagent box 7 moves to the window 17, the scanning gun scans the reagent box 7; the pinion 30 on the reagent code disc 21 revolves along with the reagent code disc 21, and the pinion 30 rotates while revolving because the pinion 30 is meshed with the fixed gear 22, the fixed gear 22 is fixed, and the pinion 30 can rotate; the two stirring columns 32 on the pinion 30 rotate, and the reagent bottle 70 is driven to rotate in the reagent box 7 by matching with the stirring sheet 71 at the bottom of the reagent bottle 70, so as to uniformly mix the reagents in the reagent bottle 70.
While embodiments of the invention have been disclosed above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in all kinds of fields of application of the invention, and further modifications may readily be effected by those skilled in the art, so that the invention is not limited to the specific details without departing from the general concept defined by the claims and the scope of equivalents.

Claims (10)

1. A novel reagent refrigeration mechanism is characterized by comprising a reagent bin, a rotating assembly, a driving assembly and a refrigeration assembly;
the driving assembly is used for improving the driving force for the rotating assembly;
the rotating assembly is arranged inside the reagent bin and comprises a main rotating piece and a secondary rotating piece; the main rotating part is used for driving the reagent box placed in the reagent bin to revolve under the driving of the driving component; the secondary rotating piece is arranged on the main rotating piece, and the secondary rotating piece revolves along with the main rotating piece and also rotates automatically, so that at least one reagent bottle on a reagent box placed in the reagent bin is driven to rotate relative to the reagent box by a stirring paddle arranged on the secondary rotating piece;
the refrigeration assembly is used for providing a refrigeration function for the reagent bin.
2. The novel reagent refrigeration mechanism of claim 1, wherein the reagent chamber comprises a bottom plate, a heat preservation cover arranged on the bottom plate, and a cover plate arranged on the heat preservation cover;
a guide groove is formed in the side wall of the upper end of the heat-insulating cover, and a guide protruding block inserted into the guide groove is arranged at the bottom of the cover plate.
3. The novel reagent refrigeration mechanism according to claim 2, wherein a window is formed in the side portion of the heat preservation cover, and an anti-fog glass assembly is arranged on the window and comprises a pressing plate connected to the side wall of the heat preservation cover, and a first glass sheet, an annular heating sheet and a second glass sheet which are sequentially stacked and arranged between the pressing plate and the side wall of the heat preservation cover.
4. The novel reagent refrigeration mechanism of claim 2, further comprising a mounting plate, wherein the reagent chamber is disposed on the mounting plate, and the refrigeration assembly is disposed at the bottom of the mounting plate;
the main rotating part comprises a large gear which is rotatably arranged on the bottom plate and a reagent coded disc which is fixedly connected on the large gear, and a fixed gear is fixedly connected on the bottom plate; the large gear, the reagent coded disc and the fixed gear are coaxially arranged;
the reagent code disc is provided with a mounting hole in the middle, and the fixed gear is fixedly connected to the bottom plate through a fixed shaft penetrating through the mounting hole.
5. The novel reagent refrigerating mechanism as claimed in claim 4, wherein the secondary rotating member comprises a plurality of pinions which are rotatably arranged on the reagent code disc in an annular array and meshed with the fixed gear, and the stirring paddle is fixedly connected to the pinions, and the stirring paddle comprises two stirring columns which are symmetrically arranged on the pinions.
6. A novel reagent refrigeration mechanism as set forth in claim 5 wherein said drive assembly includes a motor disposed on said mounting plate, a drive gear coupled to an output shaft of said motor, and a gear belt drivingly connecting said drive gear and a bull gear; when the driving gear drives the gear wheel and the reagent code disc to revolve through the gear belt, the pinion on the reagent code disc rotates under the meshing action of the fixed gear.
7. The novel reagent refrigeration mechanism of claim 2, wherein the fixed gear is provided with a pillar, the pillar is provided with a magnet, and the bottom of the cover plate is provided with an iron block for attracting the magnet.
8. The novel reagent refrigeration mechanism as claimed in claim 2, wherein a plurality of positioning grooves are uniformly arranged on the periphery of the reagent code disc at intervals, and positioning blocking sheets are further arranged on the peripheral edge of the reagent code disc; the bottom plate is provided with a first optical coupler and a second optical coupler which are used for being respectively matched with the positioning groove and the positioning baffle.
9. The novel reagent refrigeration mechanism as claimed in claim 6, wherein a plurality of mounting blocks are arranged on the bottom plate in a circular array, and a mounting groove for placing the reagent kit is formed between every two mounting blocks;
two installation fixture blocks are symmetrically arranged on two inner walls at the bottom of the opening at the inner side of the installation groove, and limiting clamping grooves are formed in the inner walls at the two sides of the middle part of the installation groove.
10. The reagent refrigeration mechanism of claim 9, wherein a stirring plate is connected to the bottom of a reagent bottle rotatably disposed on the reagent box, after the reagent box is disposed in the mounting groove, the two stirring columns are disposed on two sides of the stirring plate, respectively, and when the two stirring columns rotate, the reagent bottle can be driven by the stirring plate to rotate in the reagent box;
the kit is characterized in that bulges are symmetrically arranged on the outer walls of two sides of the upper part of the kit, two fixing clamping grooves are symmetrically arranged on the outer walls of two sides of the bottom of the kit, the kit is arranged in the mounting groove, the mounting clamping blocks are clamped in the fixing clamping grooves, and the bulges are clamped in the fixing clamping grooves.
CN201911204637.1A 2019-11-29 2019-11-29 Novel reagent refrigeration mechanism Pending CN111298857A (en)

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CN112684127A (en) * 2020-12-21 2021-04-20 江苏万略医药科技有限公司 PKPD analysis method and analysis device for novel biological medicine
CN113879682A (en) * 2021-09-18 2022-01-04 南京帝基生物科技有限公司 Kit for genetic colorectal cancer gene detection, and preparation method and system thereof
CN115009784A (en) * 2022-05-19 2022-09-06 中国科学院苏州生物医学工程技术研究所 Automatic reagent loading device with mixing function
CN115138415A (en) * 2022-08-04 2022-10-04 界首市人民医院 Clinical laboratory is with independent cold-stored equipment of depositing of test tube

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CN208568427U (en) * 2018-08-07 2019-03-01 深圳拓真生物科技有限公司 With the reagent pot for mixing structure
CN209506575U (en) * 2018-12-12 2019-10-18 深圳普门科技股份有限公司 Refrigerate reagent tray device
CN209590036U (en) * 2019-02-20 2019-11-05 重庆科斯迈生物科技有限公司 Chemiluminescence immunoassay appearance reagent storage system
CN212309630U (en) * 2019-11-29 2021-01-08 中国科学院苏州生物医学工程技术研究所 Novel reagent refrigeration mechanism

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CN112684127A (en) * 2020-12-21 2021-04-20 江苏万略医药科技有限公司 PKPD analysis method and analysis device for novel biological medicine
CN112684127B (en) * 2020-12-21 2024-02-13 江苏万略医药科技有限公司 Biological new medicine PKPD analysis method and analysis device
CN113879682A (en) * 2021-09-18 2022-01-04 南京帝基生物科技有限公司 Kit for genetic colorectal cancer gene detection, and preparation method and system thereof
CN115009784A (en) * 2022-05-19 2022-09-06 中国科学院苏州生物医学工程技术研究所 Automatic reagent loading device with mixing function
CN115138415A (en) * 2022-08-04 2022-10-04 界首市人民医院 Clinical laboratory is with independent cold-stored equipment of depositing of test tube

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