CN220350360U - Reagent storehouse and sample analyzer - Google Patents

Abstract

The utility model discloses a reagent bin and a sample analyzer. The reagent bin comprises a cooling pot, an inner ring reagent disk, an outer ring reagent disk, a rotating group, an inner ring mixing component and an outer ring mixing component; the inner ring reagent disk and the outer ring reagent disk are coaxially arranged in the cooling pot and used for placing a reagent box provided with a magnetic bead bottle; the rotating assembly is connected with the inner ring reagent disk and the outer ring reagent disk and is used for driving the inner ring reagent disk and the outer ring reagent disk to rotate independently, and the inner ring mixing assembly and the outer ring mixing assembly are respectively used for driving the magnetic bead bottles on the inner ring reagent disk and the outer ring reagent disk to rotate automatically. According to the utility model, the reagent disk is designed into an inner-outer two-ring structure coaxially arranged, so that the storage position of the reagent box in the reagent disk is increased; the inner ring and outer ring mixing assembly can be used for respectively mixing the reagent boxes on the double-ring reagent disk, and the coaxial arrangement ensures that the whole structure is simple and the space is compact; and the inner ring and the outer ring of the reagent disk can work simultaneously and independently, thereby improving the working efficiency.

Description

Reagent storehouse and sample analyzer

Technical Field

The utility model belongs to the technical field of in-vitro diagnosis, and particularly relates to a reagent bin and a sample analyzer.

Background

The sample analyzer is provided with the reagent disk for storing the reagent kit, and the common sample analyzer on the market is provided with a single-circle reagent disk, so that along with the continuous improvement of the speed measurement of the sample analyzer, the storage capacity of the reagent kit of a single machine is more required.

In order to increase the storage position of the reagent kit, two independent reagent trays are designed in the prior art, but the two independent reagent trays are designed, so that on one hand, the size of the sample analyzer is obviously increased, and the whole volume is increased; on the other hand, the kit generally comprises a reagent storage bin and a magnetic bead bottle, and two separately stored reagent trays are required to be provided with at least two independent magnetic bead mixing devices, so that the instrument structure is complex. Therefore, there is a need to design a reagent disk capable of carrying more reagent boxes and meeting the magnetic bead mixing function without increasing the original volume.

Disclosure of Invention

The utility model discloses a reagent bin and a sample analyzer, which are used for solving the problem of how to increase the storage positions of a reagent kit.

In a first aspect, the present utility model provides a reagent cartridge comprising:

a cooling pan;

the inner ring reagent disk and the outer ring reagent disk are used for placing a reagent box provided with a magnetic bead bottle;

the rotating assembly is connected with the inner ring reagent disk and the outer ring reagent disk and is used for driving the inner ring reagent disk and the outer ring reagent disk to rotate independently;

the inner ring mixing assembly and the outer ring mixing assembly are respectively used for driving the magnetic bead bottles on the inner ring reagent disk and the outer ring reagent disk to rotate automatically;

the inner ring mixing assembly, the outer ring mixing assembly, the inner ring reagent disk and the outer ring reagent disk are coaxially arranged and are jointly arranged in the cooling pot.

In some embodiments of the present utility model,

the outer lane mixing subassembly includes:

the first rotating gear is rotatably arranged on the outer ring reagent disk and is movably connected with the tail end of the magnetic bead bottle placed on the outer ring reagent disk;

a first fixed gear engaged with the first rotating gear;

the inner circle mixing subassembly includes:

the second rotating gear is rotatably arranged on the inner ring reagent disk and is connected with the tail end of the magnetic bead bottle placed on the inner ring reagent disk;

and the second fixed gear is meshed with the second rotating gear.

In some embodiments, the inner ring reagent disk and the outer ring reagent disk are located at the same horizontal plane; the first fixed gear and the second fixed gear are positioned on the same horizontal plane.

In some aspects, a first gap for accommodating the first rotating gear is formed between the first fixed gear and the cooling pan; the first fixed gear is in a step shape, and the second fixed gear is positioned on the inner side of the first fixed gear and forms a second gap with the first fixed gear, wherein the second gap is used for accommodating the second rotating gear.

In some technical schemes, the first rotating gear and the second rotating gear are respectively connected with the tail end of the magnetic bead bottle through a uniform mixing central shaft; a mounting bearing is sleeved on the uniformly mixed central shaft and can rotate in the mounting bearing; the mounting bearing is used for mounting the uniformly mixed central shaft on a corresponding outer ring reagent disk or inner ring reagent disk.

In some technical schemes, the inner ring reagent disk and the outer ring reagent disk are respectively provided with a plurality of reagent box accommodating grooves along the circumferential direction; the first fixed gear is meshed with a plurality of first rotating gears at the same time; the second fixed gear is simultaneously engaged with a plurality of the second rotating gears.

In some aspects, the rotating assembly includes:

the rotating shaft comprises a central fixed shaft for supporting the rotating shaft to be installed in the cooling pot, an inner core shaft which is connected with the inner ring reagent disk and is rotatably arranged in the central fixed shaft, and an outer sleeve shaft which is connected with the outer ring reagent disk and is rotatably arranged outside the central fixed shaft;

the first driving mechanism is connected with the outer sleeve shaft and is used for driving the outer sleeve shaft to rotate so as to drive the outer ring reagent disk to rotate;

and the second driving mechanism is connected with the inner mandrel and is used for driving the inner mandrel to rotate so as to drive the inner ring reagent disk to rotate.

In some embodiments, the first fixed gear and the second fixed gear are fixed on the central fixed shaft.

In a second aspect, the present utility model provides a sample analyzer comprising the reagent cartridge of the first aspect.

Parts, positional relationships, connection relationships, and the like not written in the present application may be realized by the prior art. Compared with the prior art, the beneficial effects are that:

according to the utility model, the reagent disk is designed into an inner ring and outer ring structure which are coaxially arranged, and the reagent disk on the inner ring and the outer ring is provided with the reagent box accommodating groove, so that the storage position of the reagent box in the reagent disk is increased, and the requirements of a plurality of test items and high detection efficiency are met; meanwhile, the inner ring and the outer ring of the reagent disk and the external driving device independently rotate during operation, and when the inner ring and the outer ring of the reagent disk can jointly operate with other modules of the whole instrument on the premise of considering the volume size of the reagent disk, the inner ring and the outer ring of the reagent disk can simultaneously and independently work, so that the working efficiency is improved. Further, the double-ring reagent disk is respectively provided with the inner ring and the outer ring mixing components, and the inner ring and the outer ring mixing components can respectively mix the reagent boxes on the double-ring reagent disk under the condition of coaxiality, so that the whole structure is simple and the space is compact due to the coaxiality.

Drawings

FIG. 1 is a disassembled structure view of a reagent cartridge in a state that a heat insulation cover is partially opened;

FIG. 2 is a top view of the reagent cartridge in a fully opened state of the thermal cover;

FIG. 3 is a schematic view of the structure of the reagent cartridge in a capped state;

FIG. 4 is a top view of an inner ring reagent disk;

FIG. 5 is a diagram of an outer ring reagent disk configuration;

FIG. 6 is a schematic perspective view of a kit;

FIG. 7 is a perspective view of the rotating assembly;

FIG. 8 is an exploded view of a partial structure of the spin mechanism of the magnetic bead bottle;

fig. 9 is a cross-sectional view of a reagent cartridge.

Reference numerals: 1-cooling pot, 101-heat preservation cover, 102-kit taking and placing hole, 103-reagent sucking hole, 2-inner ring reagent disk, 3-outer ring reagent disk, 4-kit holding groove, 5-rotating component, 501-rotating shaft, 50101-inner core shaft, 50102-center fixed shaft, 50103-outer sleeve shaft, 502-first driving mechanism, 503-second driving mechanism, 6-kit, 601-magnetic bead bottle, 60101-cross bar, 602-frame body, 603-through hole, 604-reagent holding cavity, 8-mixing component, 801-first rotating gear, 802-first fixed gear, 803-second rotating gear, 804-second fixed gear, 805-mounting bearing, 806-mixing center shaft, 80601-pusher dog.

Detailed Description

The following description of the embodiments of the present utility model will be made clearly and completely, and it is apparent that the described embodiments are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art without the exercise of inventive faculty, are intended to be within the scope of the utility model.

As shown in fig. 1 and 2, the reagent bin comprises a cooling pot 1, an inner ring reagent disk 2, an outer ring reagent disk 3, a rotating assembly 5, an inner ring mixing assembly and an outer ring mixing assembly; the inner ring reagent disk 2 and the outer ring reagent disk 3 are coaxially arranged and are used for placing a reagent box 6 provided with a magnetic bead bottle 601; the rotating assembly 5 is connected with the inner ring reagent disk 2 and the outer ring reagent disk 3 and is used for driving the inner ring reagent disk 2 and the outer ring reagent disk 3 to rotate independently; the inner ring mixing assembly and the outer ring mixing assembly are respectively used for driving the magnetic bead bottles 601 on the inner ring reagent disk 2 and the outer ring reagent disk 3 to rotate automatically; the inner ring mixing assembly, the outer ring mixing assembly, the inner ring reagent disk 2 and the outer ring reagent disk 3 are coaxially arranged and are jointly arranged in the cooling pot 1.

The reagent bin adopts the design of the inner and outer ring reagent discs which are coaxially arranged, so that the whole structure of the reagent bin is exquisite and small while the storage capacity of the reagent is enlarged, and meanwhile, the requirement of high-efficiency working with other modules of the whole instrument can be met. Further, the double-ring reagent disk is respectively provided with the inner ring and the outer ring mixing components, and the inner ring and the outer ring mixing components can respectively mix the reagent boxes on the double-ring reagent disk under the condition of coaxiality, so that the whole structure is simple and the space is compact due to the coaxiality.

The refrigerating mode of the reagent bin is compressor refrigeration, namely, a low-temperature medium is arranged at the periphery of the cooling pot 1 for heat exchange in the reagent bin, and the medium after heat exchange returns to the refrigerating system for refrigeration and then enters the reagent bin, which belongs to the prior art and is not described more herein. As shown in fig. 3, in order to increase the tightness of the whole cooling pot 1 and reduce the leakage of cool air in the cooling pot 1, the pot body of the cooling pot 1 is surrounded by a heat-insulating layer, and the heat-insulating layer is specifically heat-insulating cotton; and the top of the cooling pan 1 is provided with a heat-retaining cover 101 (shown as an open state), wherein the heat-retaining cover 101 is used to close the cooling pan 1. In order to facilitate the whole operation of the reagent bin, a reagent box taking and placing hole 102 and a reagent sucking hole 103 are arranged on the heat insulation cover 101, the reagent box taking and placing hole 102 is convenient for replacing or increasing and decreasing a small amount of reagent boxes 6, and the reagent sucking hole 103 is convenient for sucking the reagent.

As shown in fig. 4 and 5, the reagent trays of the inner and outer rings are uniformly distributed in the circumferential direction in the reagent cassette accommodating grooves 4 for accommodating the reagent cassettes 6. In this embodiment, there are 12 reagent box holding grooves 4 on the inner ring reagent disk 2, 24 reagent box holding grooves 4 on the outer ring reagent disk 3, as shown in fig. 6, the reagent box 6 includes a frame 602, a through hole 603 for installing a magnetic bead bottle 601 and a plurality of reagent holding cavities 604 are arranged on the frame 602, the magnetic bead bottle 601 is rotatable in the through hole 603, the reagent holding cavities 604 are used for holding reagents according to actual needs, and in order to prevent the reagent in the reagent box from evaporating too fast, reagent covers are added on the magnetic bead bottle 601 and the reagent holding cavities 604. In order to facilitate accurate positioning of the kit 6 into the kit accommodating groove 4, guiding and positioning ribs are arranged on the inner side of the kit accommodating groove 4. In order to enable the cold air in the reagent bin to directly reach the reagent box 6, the bottom of the reagent box accommodating groove 4 is provided with a hollow structure.

As shown in fig. 7, the rotation assembly 5 includes a rotation shaft 501, a first driving mechanism 502, and a second driving mechanism 503. A through hole is arranged at the center of the bottom surface of the cooling pot 1 for the rotating shaft 501 to extend into the cooling pot 1, and the inner ring reagent disk 2 and the outer ring reagent disk 3 are jointly arranged on the rotating shaft 501.

As shown in fig. 7, the rotary shaft 501 is a three-layer sleeve type including a center fixing shaft 50102 for supporting the rotary shaft 501 to be installed in the cooling pan 1, an inner core shaft 50101 coupled to the inner ring reagent disk 2 and rotatably provided in the center fixing shaft 50102, and an outer sleeve shaft 50103 coupled to the outer ring reagent disk 3 and rotatably provided outside the center fixing shaft 50102. Wherein the inner mandrel 50101 is rotatably disposed inside the center fixed shaft 50102, the outer sleeve shaft 50103 is rotatably disposed outside the center fixed shaft 50102, and the center fixed shaft 50102 support shaft 501 is mounted in the cooling pan 1.

In one possible implementation, the first driving mechanism 502 and the second driving mechanism 503 are spatially layered, where the first driving mechanism 502 is located above the second driving mechanism 503, and the first driving mechanism 502 is connected to the outer sleeve shaft 50103 and is used to drive the outer sleeve shaft 50103 to rotate, so as to drive the outer ring reagent disk 3 to rotate. A partition plate is arranged between the first driving mechanism 502 and the second driving mechanism 503, the inner spindle 50101 extends to the lower side of the partition plate, and the second driving mechanism 503 is connected with the inner spindle 50101 below the partition plate and is used for driving the inner spindle 50101 to rotate so as to drive the inner ring reagent disk 2 to rotate.

In this embodiment, an inner ring reagent disk 2 is mounted on an inner spindle 50101; the outer ring reagent disk 3 is mounted on the outer sleeve shaft 50103 so that rotation of the inner and outer sleeve shafts 50101, 50103, respectively, can drive independent rotation of the inner and outer ring reagent disks 2, 3.

As shown in fig. 9, the mixing assembly 8 includes an inner ring mixing assembly and an outer ring mixing assembly, the outer ring mixing assembly including a first rotating gear 801 and a first fixed gear 802; the plurality of first rotating gears 801 are rotatably arranged on the outer ring reagent disk 3 and are movably connected with the tail end of the magnetic bead bottle 601 placed on the outer ring test disk 3; the first fixed gear 802 meshes with the first rotating gear 801; the inner ring mixing component comprises a second rotating gear 803 and a second fixed gear 804, and a plurality of second rotating gears 803 are rotatably arranged on the inner ring reagent disk 2 and are movably connected with the tail end of the magnetic bead bottle 601 placed on the inner ring reagent disk 2; a second fixed gear 804 meshes with the second rotating gear 803.

In this embodiment, the inner ring reagent disk 2 and the outer ring reagent disk 3 are located on the same horizontal plane; the first fixed gear 802 and the second fixed gear 804 are located at the same horizontal plane. The arrangement can improve space utilization on the one hand, on the other hand, the coplanarity of inner circle reagent dish 2 and outer lane reagent dish 3 makes the kit coplane on the inner and outer circle reagent dish, and the reagent of being convenient for is put and is convenient for absorb reagent to get.

In the present embodiment, a first fixed gear 802 and a second fixed gear 804 are fixed to the outer peripheral portion of the center fixed shaft 50102. For the purpose of coplanarity, the inner wall of the cooling pot 1, the outer ring reagent disk 3 and the first fixed gear 802 are all in a step shape, so that space is provided for coaxial nesting of a plurality of components. A first gap for accommodating a first rotating gear 801 is formed between the first fixed gear 802 and the cooling pan 1; the first fixed gear 802 is stepped, and the second fixed gear 804 is located inside the first fixed gear 802, and forms a second gap with the first fixed gear 802 for accommodating the second rotating gear 803. When the first fixed gear 802 and the second fixed gear 804 are installed in the cooling pan 1, the first rotating gear 801 and the second rotating gear 803 on the first fixed gear 802 and the second fixed gear 804 extend to the second gap and the first gap, respectively, so that uniform mixing is achieved.

The inner ring reagent disk 2 and the outer ring reagent disk 3 are respectively provided with a plurality of reagent box accommodating grooves 4 along the circumferential direction, and the first fixed gear 802 is simultaneously meshed with a plurality of first rotating gears 801; the second fixed gear 804 simultaneously meshes with the plurality of second rotating gears 803. When the first fixed gear 802 and the second fixed gear 804 rotate, the first rotating gear 801 and the second rotating gear 803 are driven to rotate.

As shown in fig. 8, a first rotating gear 801 and a second rotating gear 803 (the same as the first rotating gear 801 in fig. 8) are respectively connected with the end of the magnetic bead bottle 601 through a mixing central shaft 806, and a mounting bearing 805 is sleeved on the mixing central shaft 806 and can rotate in the mounting bearing 805; a pair of mutually symmetrical pulling claws 80601 are arranged at the joint of the uniformly mixed central shaft 806 and the tail end of the magnetic bead bottle 601, and the two pulling claws 80601 are matched with a cross rod 60101 at the bottom of the magnetic bead bottle 601. When the first fixed gear 802 and the second fixed gear 804 respectively drive the first rotating gear 801 and the second rotating gear 803 to rotate, the mixing center shaft 806 also rotates along with the rotation, and then the two pulling claws 80601 also rotate, so that the pulling claws 80601 drive the magnetic bead bottle 601 to rotate by pulling the cross rod 60101, thereby realizing that the magnetic bead bottle 601 can rotate and revolve along with the inner ring reagent disk and the mixing force of the magnetic bead bottle 601 is increased.

As shown in fig. 9, the outer ring reagent disk 3 is configured to be stepped, so that the inner ring reagent disk 2 and the outer ring reagent disk 3 can be coplanar under the coaxial condition, further, the first fixed gear 802 and the second fixed gear 804 are coplanar, the first horizontal plane where the first fixed gear 802 and the second fixed gear 804 are located is slightly reduced relative to the second horizontal plane formed by the inner ring reagent disk 2 and the outer ring reagent disk 3, and a space is provided for the first gap and the second gap.

In one possible way, the outer ring reagent disk 3 comprises a turntable disposed on the outer quill 50103 and an annular disk secured to the outside of the turntable; the annular disc is detachably connected with the turntable, and the annular disc and the turntable are in a step shape and are used for bearing the reagent kit.

The utility model also provides a sample analyzer, which comprises the reagent bin. The specific structure of the reagent bin refers to the above embodiment, and because the sample analyzer adopts all the technical solutions in the above embodiment, the sample analyzer at least has all the beneficial effects brought by the technical solutions in the above embodiment, and will not be described in detail herein.

The above examples merely represent a few embodiments of the present utility model, which are described in more detail and are not to be construed as limiting the scope of the patent. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the utility model, which are all within the scope of the utility model. Accordingly, the scope of protection of the present utility model is to be determined by the appended claims.

Claims (9)

1. A reagent cartridge, comprising:

a cooling pan (1);

the inner ring reagent disk (2) and the outer ring reagent disk (3) are used for placing a reagent box (6) provided with a magnetic bead bottle (601);

the rotating assembly (5) is connected with the inner ring reagent disk (2) and the outer ring reagent disk (3) and is used for driving the inner ring reagent disk (2) and the outer ring reagent disk (3) to rotate independently;

the inner ring mixing assembly and the outer ring mixing assembly are respectively used for driving the magnetic bead bottles (601) on the inner ring reagent disk (2) and the outer ring reagent disk (3) to rotate automatically;

the inner ring mixing assembly, the outer ring mixing assembly, the inner ring reagent disk (2) and the outer ring reagent disk (3) are coaxially arranged and are jointly arranged in the cooling pot (1).

2. The reagent cartridge of claim 1, wherein,

the outer lane mixing subassembly includes:

the first rotating gear (801) is rotatably arranged on the outer ring reagent disk (3) and is connected with the tail end of the magnetic bead bottle (601) placed on the outer ring reagent disk (3);

a first fixed gear (802) meshed with the first rotating gear (801);

the inner circle mixing subassembly includes:

the second rotating gear (803) is rotatably arranged on the inner ring reagent disk (2) and is connected with the tail end of the magnetic bead bottle (601) placed on the inner ring reagent disk (2);

and a second fixed gear (804) meshed with the second rotating gear (803).

3. The reagent cartridge of claim 2, wherein the inner ring reagent disk (2) and the outer ring reagent disk (3) are located at the same horizontal plane; the first fixed gear (802) and the second fixed gear (804) are located at the same horizontal plane.

4. The reagent cartridge of claim 2, wherein a first gap for accommodating the first rotating gear (801) is formed between the first fixed gear (802) and the cooling pan (1); the first fixed gear (802) is in a step shape, and the second fixed gear (804) is positioned on the inner side of the first fixed gear (802) and forms a second gap with the first fixed gear (802) for accommodating the second rotating gear (803).

5. The reagent cartridge of claim 2, wherein the first rotating gear (801) and the second rotating gear (803) are each connected to the end of the magnetic bead bottle (601) by a mixing center shaft (806);

a mounting bearing (805) is sleeved on the uniformly mixed central shaft (806), and the uniformly mixed central shaft can rotate in the mounting bearing (805); the mounting bearing (805) is used for mounting the mixing center shaft (806) on the corresponding outer ring reagent disk (3) or inner ring reagent disk (2).

6. The reagent cartridge according to claim 2, wherein the inner ring reagent disk (2) and the outer ring reagent disk (3) are each provided with a plurality of reagent cartridge accommodating grooves (4) along a circumferential direction; the first fixed gear (802) is simultaneously meshed with a plurality of the first rotating gears (801); the second fixed gear (804) is simultaneously engaged with a plurality of the second rotating gears (803).

7. The reagent cartridge of claim 2, wherein the rotating assembly (5) comprises:

the rotating shaft (501) comprises a central fixed shaft (50102) for supporting the rotating shaft (501) to be installed in the cooling pot (1), an inner core shaft (50101) connected with the inner ring reagent disk (2) and rotatably arranged in the central fixed shaft (50102), and an outer sleeve shaft (50103) connected with the outer ring reagent disk (3) and rotatably arranged outside the central fixed shaft (50102);

the first driving mechanism (502) is connected with the outer sleeve shaft (50103) and is used for driving the outer sleeve shaft (50103) to rotate so as to drive the outer ring reagent disk (3) to rotate;

and the second driving mechanism (503) is connected with the inner mandrel (50101) and is used for driving the inner mandrel (50101) to rotate so as to drive the inner ring reagent disk (2) to rotate.

8. The reagent cartridge of claim 7, wherein the first fixed gear (802) and the second fixed gear (804) are fixed on the central fixed shaft (50102).

9. A sample analyzer comprising the reagent cartridge of any one of claims 1-8.