CN218099211U - Reagent mixing system and chemiluminescence immunoassay appearance - Google Patents

Abstract

The utility model relates to a reagent mixing system and chemiluminescence immunoassay appearance, reagent mixing system includes the center ring, bear dish and first reagent bottle, it establishes in the center ring outside and rotatory for the center ring to bear the dish to enclose, first reagent bottle can twist reverse to be fixed on bearing the dish, be equipped with action portion on the first reagent bottle, the correspondence is equipped with trigger part on the center ring, action portion and trigger part are located first reagent bottle and center ring side towards the other side each other respectively, it rotates the corresponding position of action portion and trigger part to bear the dish, trigger part and action part contact make first reagent bottle use its fixed position on bearing the dish to take place to twist reverse as the center. The reagent mixing system simple structure compactness that this application embodiment provided utilizes the contact collision of action portion and trigger part can realize the mixing of reagent in the first reagent bottle, and the force of exerting makes first reagent bottle produce acceleration when owing to the collision, can improve the mixing effect of reagent in the first reagent bottle.

Description

Reagent mixing system and chemiluminescence immunoassay appearance

Technical Field

The application relates to the technical field of medical detection equipment, in particular to a reagent blending system and a chemiluminescence immunoassay analyzer.

Background

Chemiluminescence immunoassay analyzer is a tool for diagnosing some diseases by utilizing immunodiagnosis technology. The chemiluminescence immunity analyzer mainly comprises: sample storehouse, reagent storehouse, incubation dish etc. device, wherein the reagent storehouse is the device responsible for providing reaction reagent in the chemiluminescence immunoassay appearance. Since the reagent contains a solid-phase reagent, in order to obtain a uniformly distributed solid-phase reagent, the solid-phase reagent in the reagent chamber needs to be kept in a uniformly mixed state so that a uniformly mixed reagent can be obtained when the reagent needle extracts the solid-phase reagent. At present, most of mixing devices in the prior art are complex in structure and expensive in price, so that later maintenance cost is high, and popularization and application of a mixing technology are limited to a certain extent. In addition, some blending devices may cross-infect reagents due to blending using a stirring rod. In addition, reagent bottles in some reagent mixing devices are in a uniform speed state during mixing, so that reagents in the reagent bottles cannot be uniformly mixed, and even a wall hanging phenomenon can occur.

SUMMERY OF THE UTILITY MODEL

The application provides a reagent mixing system and immunoassay aiming at the technical problems in the prior art. Through utilizing the contact collision between action portion and the trigger part to realize the purpose to the reagent mixing in the first reagent bottle, the reagent mixing system simple structure that this application embodiment provided is compact, can realize improving the mixing effect of reagent to the reagent variable speed mixing in the first reagent bottle.

The embodiment of the application provides a reagent mixing system, includes: the reagent bottle holder is characterized in that the first reagent bottle can be fixed on the bearing disc in a twisting mode, an action part is arranged on the first reagent bottle, a trigger part is correspondingly arranged on the center ring, the action part and the trigger part are respectively positioned on the side faces, facing to each other, of the first reagent bottle and the center ring, the bearing disc rotates to the corresponding position of the action part and the trigger part, and the trigger part is in contact with the action part and enables the first reagent bottle to be twisted by taking the fixed position of the first reagent bottle on the bearing disc as the center.

Optionally, bear and be equipped with a plurality of mixing bases along the circumferencial direction interval on the dish, the mixing base is used for twistingly fixing first reagent bottle on bearing the dish.

Optionally, the blending base comprises a bottom support and an elastic element, wherein one end of the elastic element is fixedly connected with the bearing disc, the other end of the elastic element is connected with the bottom support, and the elastic element is used for enabling the bottom support to rotate back and forth; the collet sets up in the elastic element top to be connected with the bottom of first reagent bottle, action portion sets up the side at the collet, and the collet is used for transmitting the rotation motion to first reagent bottle.

Optionally, the blending base further comprises a bottom support ring, the bottom support ring is fixed on the bearing disc, and a first groove is formed in the bottom support ring; the positions below the bottom support and corresponding to the first grooves are provided with protrusions which are rotatably connected with the first grooves.

Optionally, the collision part of the trigger part and the action part is made of elastic material.

Optionally, the action part is a first arc-shaped lug, and the trigger part is a ball plunger; the arc-shaped lug is provided with a first positioning hole, the bearing disc is provided with a second positioning hole, the elastic element is a torsion spring, one end of the torsion spring is fixed in the first positioning hole, and the other end of the torsion spring is fixed in the second positioning hole; the bearing plate rotates to enable the ball plunger to abut against the arc-shaped convex lug, and the torsion spring is in torsional deformation, so that the first reagent bottle rotates relative to the bearing plate.

Optionally, the action part is a first triangular protrusion, the trigger part is a cylindrical protrusion, and a spring is arranged inside the cylindrical protrusion.

Optionally, the action part is a second triangular protrusion, the trigger part is a second arc-shaped lug, and a spring is arranged inside the arc-shaped lug.

Optionally, a transmission part is correspondingly arranged on the first reagent bottle and on the inner side of the bottom support, so that the first reagent bottle and the bottom support rotate along the same direction.

Optionally, the transmission portion comprises: the second groove is arranged on the side surface of the first reagent bottle along the axial direction, and the triangular rib is arranged on the inner side of the bottom support; the triangular convex rib is embedded into the second groove, and when the bottom support rotates, the first reagent bottle is driven to rotate.

Optionally, the transmission portion comprises: the clamping jaw is arranged at the bottom of the first reagent bottle, and the convex teeth are arranged on the inner side of the bottom support; the claw is engaged with the convex teeth, and when the bottom support rotates, the first reagent bottle is driven to rotate.

Optionally, the transmission portion comprises: the side surface of the first reagent bottle is provided with an arc convex rib along the axial direction and an arc convex rib arranged on the inner side of the bottom support; the arc-shaped convex strips are meshed with the arc-shaped convex edges, and when the bottom support rotates, the first reagent bottle is driven to rotate.

Optionally, the blending system further comprises: the clamping disc is arranged above the central ring and connected with the bearing disc, and a mixing clamping position is arranged at the position, corresponding to the mixing base, of the clamping disc.

Optionally, the first reagent bottle is placed in a mixing block, and the mixing block is used for limiting the movement of the first reagent bottle in the circumferential direction.

Optionally, the blending system further comprises: the kit is positioned in the mixing clamping position and used for bearing a first reagent bottle, a second reagent bottle and a third reagent bottle.

Optionally, the diameter of the first reagent bottle decreases progressively from the bottle mouth to the bottle bottom in the axial direction, and a one-way chamfer is arranged on the side face of the first reagent bottle and used for limiting the movement of the first reagent bottle in the axial direction.

Optionally, the position of the symbol corresponds to the position of the mixing position, and the symbol is used for marking the position of the mixing position.

Optionally, the blending system further comprises: the bin body and the bin cover, the center ring and the bearing plate are arranged in the bin body, and the bin cover is arranged above the bin body.

Optionally, the bin cover comprises a first bin cover and a second bin cover, the second bin cover is connected with the bin body, a reagent outlet corresponding to the blending clamping position is arranged on the second bin cover, and the reagent outlet is used for an outlet when a reagent in the reagent bottle is sucked by the reagent needle; the first bin cover is movably connected with the second bin cover, and the center of the first bin cover deviates from the circle center of the second bin cover by a preset distance.

Optionally, a sensor is arranged on the second bin cover, a signal emitter is arranged at a position of the first bin cover corresponding to the sensor, and the sensor is used for sensing the placement state of the first bin cover.

Optionally, the sensor is a hall sensor and the signal emitter is a magnetic element.

Optionally, the system further comprises a code scanner arranged outside the cartridge body and used for scanning and reading information of the reagent kit.

Optionally, the system further comprises: the refrigerating unit is arranged below the bin body and used for keeping the temperature of the bin body within a preset range.

Optionally, the system further comprises: the air channel comprises a fan and a baffle, the baffle encloses a channel, the channel is arranged below the refrigerating unit, and the fan is arranged at the outlet of the channel and used for discharging heat generated by the refrigerating unit.

The application also provides a chemiluminescence immunoassay analyzer, which comprises an incubation disc and a reagent blending system according to any one of the preceding items, wherein the reagent blending system is used for providing the blended reagent for a reaction tube in the incubation disc.

The reagent mixing system has the advantages that the action part and the trigger part are arranged, and the contact collision between the trigger part and the action part is utilized to complete the mixing of the reagent in the first reagent bottle, so that the reagent mixing system provided by the embodiment of the application has a simple and compact structure, and can complete the mixing of the reagent without more power structures. In addition, because the force of exerting makes first reagent bottle produce acceleration during the collision, can improve the mixing effect of reagent in the first reagent bottle. Compared with other uniform mixing technologies, the accelerated mixing technology has greater advantages in the aspect of mixing reagents.

Drawings

Preferred embodiments of the present application will now be described in further detail with reference to the accompanying drawings, in which:

FIG. 1 is a schematic structural diagram of a portion of a reagent blending system according to an embodiment of the present disclosure;

FIG. 2 is a schematic diagram of a mixing base structure of a reagent mixing system according to an embodiment of the present disclosure;

FIG. 3 is a schematic structural diagram of an action part and a trigger part in another reagent mixing system according to an embodiment of the present application;

FIG. 4 is a schematic structural diagram of an action part and a trigger part in another reagent mixing system according to an embodiment of the present application;

FIG. 5 is a schematic structural diagram of another transmission part proposed in the embodiment of the present application;

FIG. 6 is a schematic structural diagram of another transmission part proposed in the embodiment of the present application;

FIG. 7 is a schematic diagram of a portion of another reagent blending system provided in accordance with an embodiment of the present application;

FIG. 8 is a sectional view of a cartridge according to an embodiment of the present application;

FIG. 9 is a schematic structural diagram of another reagent blending system according to an embodiment of the present disclosure;

fig. 10 is a sectional view of a portion of the structure of fig. 9.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments in the present application without making any creative effort belong to the protection scope of the present application.

In the following detailed description, reference is made to the accompanying drawings that form a part hereof, and in which is shown by way of illustration specific embodiments of the application. In the drawings, like numerals describe substantially similar components throughout the different views. Various specific embodiments of the present application are described in sufficient detail below to enable those skilled in the art to practice the teachings of the present application. It is to be understood that other embodiments may be utilized and structural, logical or electrical changes may be made to the embodiments of the present application.

Fig. 1 is a schematic structural diagram of a part of a reagent blending system according to an embodiment of the present application. As shown in fig. 1, the reagent mixing system includes: the reagent bottle loading device comprises a center ring 101, a bearing plate 102 and a first reagent bottle 103, wherein the bearing plate 102 is arranged outside the center ring 101 in a surrounding mode and rotates relative to the center ring 101, the first reagent bottle 103 can be fixed on the bearing plate 102 in a twisting mode, an action part 104 is arranged on the first reagent bottle 103, a trigger part 105 is correspondingly arranged on the center ring 101, the action part 104 and the trigger part 105 are respectively located on the side faces, facing each other, of the first reagent bottle 103 and the center ring 101, the bearing plate 102 rotates to the corresponding position of the action part 104 and the trigger part 105, and the trigger part 105 is in contact with the action part 104 and enables the first reagent bottle 103 to be twisted by taking the fixed position of the trigger part on the bearing plate 102 as the center. In some embodiments, optionally, the action part 104 may be directly disposed on the first reagent bottle 103, and in other embodiments, the action part 104 is connected to the first reagent bottle 103 through another structure, i.e., the action part 104 may be indirectly disposed on the first reagent bottle 103. In some embodiments, optionally, the first reagent bottle is a magnetic bead bottle, magnetic bead particles are inside the first reagent bottle, and the first reagent bottle is uniformly mixed in the first reagent bottle under the action of the action part and the trigger part.

The first reagent bottles 103 on the carrier plate 102 rotate around the center ring 101 in accordance with the rotation of the carrier plate 102, and a plurality of trigger portions 105 are provided on the center ring 101 at intervals along the circumferential direction. The operation unit 104 provided in the first reagent bottle is turned on the carrier tray 102 to a position corresponding to the trigger unit 105 on the center ring 101 following the first reagent bottle 103, and the operation unit 104 and the trigger unit 105 are brought into contact with each other. Since the carrier tray 102 is still rotating, the first reagent bottle 103 is driven to rotate by the operation unit 104 under the restriction of the trigger unit 105, and when the operation unit 104 rotates to a position tangential to the rotation direction of the carrier tray 102, the operation unit leaves the trigger unit. In some embodiments, optionally, an elastic element is arranged between the first reagent bottle and the carrier plate, and the first reagent bottle can rotate on the carrier plate. When the action part leaves the trigger part, the first reagent bottle shakes under the action of the elastic force of the elastic element until the first reagent bottle stops or contacts with the next trigger part.

In some embodiments, optionally, the carrier plate is rotated by the power mechanism, and then the first reagent bottle is rotated around the central ring.

The reagent mixing system has the advantages that the action part and the trigger part are arranged, and the contact collision between the trigger part and the action part is utilized to complete the mixing of the reagent in the first reagent bottle, so that the reagent mixing system provided by the embodiment of the application has a simple and compact structure, and can complete the mixing of the reagent without more power structures. In addition, because the contact that utilizes action portion and trigger part comes the transmission motion, so, the effort that action portion bore can make the motion of first reagent bottle appear the acceleration, and then compare in other uniform mixing technique, variable speed mixing technique has bigger advantage in the aspect of mixing reagent.

As shown in fig. 1, a plurality of mixing bases 106 are provided on the carrier plate 102 at intervals along the circumferential direction, and the mixing bases 106 are used for rotatably fixing the first reagent bottles 103 on the carrier plate 102. In some embodiments, optionally, a blending base is not required to be disposed on the carrying tray 102, the carrying tray may be directly connected to the first reagent bottle 103 through an elastic element, the carrying tray 103 is provided with a concave structure, a protruding structure is disposed at the bottom of the first reagent bottle, the protruding structure penetrates through the elastic element and is sunk into the concave structure, and the first reagent bottle and the carrying tray may be fixedly connected in a rotatable manner. Alternatively, the carrier plate 102 may be connected to the first reagent bottle 103 via the mixing base 106. The mixing base 106 is provided on the carrier plate 102 in the circumferential direction, and the plurality of first reagent bottles 103 are fixed to the carrier plate 102 so as to be rotatable, and mixing of the reagent is performed by the contact between the operating portion 104 and the trigger portion 105.

Fig. 2 is a schematic structural diagram of a blending base of a reagent blending system according to an embodiment of the present application. Referring to fig. 1 and 2, the blending base 106 includes a bottom support 1061 and an elastic element 1062, wherein one end of the elastic element 1062 is fixedly connected to the carrier tray 102, and the other end is connected to the bottom support 1061, in the embodiment shown in fig. 2, the elastic element 1062 is a torsion spring, and under the alternating action of the torsion force and the elastic restoring force of the torsion spring, the bottom support can be rotated back and forth. The mounting 1061 is disposed above the elastic member 1062 and is connected to the bottom of the first reagent bottle 103, and the actuating part 104 is disposed at the side of the mounting 1061, the mounting 1061 being used to transmit rotational motion to the first reagent bottle 103.

In some examples, optionally, the action part 104 may be provided with a fixing hole, the elastic element 1062 is made of a metal material, and one end of the elastic element 1062 may pass through and be fixed in the positioning hole. The carrier plate 102 is also provided with a fixing hole, and the other end of the elastic element 1062 passes through the fixing hole and is fixed on the carrier plate 102. First reagent bottle bottom and collet internal connection, under the drive of collet, first reagent bottle can take place to rotate.

The elastic element and the bottom support are arranged in the blending base, so that the first reagent bottle can stably rotate on the bearing plate, and the first reagent bottle can be conveniently taken out of the bearing plate due to the fact that the elastic element is connected with the bottom support, and the requirement on the structure of the first reagent bottle is avoided. Elastic element can also make first reagent bottle take place reciprocating rotation for because not uniform velocity rotation, make the mixture of the reagent in the first reagent bottle become more even, can reduce the emergence of wall built-up phenomenon to a certain extent.

As shown in fig. 2, the blending base further includes a bottom support ring 1063, the bottom support ring 1063 is fixed on the bearing tray 102, and a first groove 201 is formed in the bottom support ring; a protrusion 202 is arranged at a position corresponding to the first groove 201 below the bottom support, and the protrusion 202 is rotatably connected with the first groove 201. Wherein, the first groove 201 is arranged at the central position of the shoe ring and has a certain depth, and the bulge 202 is arranged at the central position of the shoe and corresponds to the position of the first groove 201. The projection 202 may be inserted into the first recess 201, and when the action part rotates the shoe, the projection 202 rotates in the first recess 201. In addition, the protrusion 202 inserted in the first groove can limit the position of the bottom support 1061, and prevent the bottom support from deviating far from the original position when rotating, which affects the next contact between the action part and the trigger part.

In some embodiments, in order to reduce friction between the action part and the trigger part, the collision part of the trigger part and the action part is made of elastic material. Thus, when the trigger part is contacted with the action part and is extruded, the friction between the trigger part and the action part can be reduced in a deformation mode, and the abrasion problem caused by frequent contact between the trigger part and the action part is prevented. When the abrasion is serious, the contact duration between the action part and the trigger part is influenced, and the blending force or speed of the first reagent bottle may be further influenced.

Referring to fig. 1 and 2, in some embodiments, optionally, the actuating portion 104 is a first arc-shaped lug 208, and the triggering portion 105 is a ball plunger 107. The first arc-shaped lug 208 is provided with a first positioning hole 204, the bearing tray 102 is provided with a second positioning hole 206, the elastic element 1062 is a torsion spring 207, one end of the torsion spring 207 is fixed in the first positioning hole 204 on the bottom bracket ring, and the other end is fixed in the second positioning hole 206 on the bearing tray. The rotation of the carrier plate 102 causes the ball plunger 107 to abut against the first arc-shaped lug 208, and the torsion spring 207 is torsionally deformed, so that the first reagent bottle 103 rotates relative to the carrier plate 102. Because the torsional spring needs to release elastic potential energy after being deformed, the first arc-shaped lug can still continuously shake for a period of time after leaving the ball plunger. In addition, utilize the torsional spring to drive first reagent bottle and take place to rotate, can make first reagent bottle take place variable speed motion to the torsional spring takes place the power that produces after the deformation great, makes first reagent bottle can take place acutely rotatory, and the reagent that is arranged in first reagent bottle can be by the homogeneous mixing. In addition, the rotating speed of the bearing disc and the forward and reverse switching frequency can be further controlled by adjusting the transmission mechanism, so that various blending effects of the reagents can be flexibly realized.

The inside spring that can set up of bulb plunger 107, when first arc lug 208 and bulb plunger 107 take place the contact, elastic deformation can take place, both can reduce wearing and tearing, can make first reagent bottle 103 take place to rotate when triggering the torsion of mixing base 106 again.

Fig. 3 is a schematic structural diagram of an action part and a trigger part in another reagent mixing system according to an embodiment of the present application. The actuating part 104 in the embodiment shown in fig. 2 is a first triangular protrusion 301 in the embodiment shown in fig. 3, the trigger part 105 in the embodiment shown in fig. 2 is a cylindrical protrusion 302 in the embodiment shown in fig. 3, and a spring is arranged inside the cylindrical protrusion 302. The first triangular protrusion 301 is disposed on the bottom support 1061, the first triangular protrusion 301 is disposed with a first positioning hole 204, the carrier tray 102 is disposed with a second positioning hole 206, the elastic element 1062 is a torsion spring 207, one end of the torsion spring 207 is fixed in the first positioning hole 204, and the other end is fixed in the second positioning hole 206. The bearing plate rotates to enable the first triangular bulge to abut against the cylindrical bulge, and the torsion spring is in torsional deformation, so that the first reagent bottle rotates relative to the bearing plate.

Fig. 4 is a schematic structural diagram of an action part and a trigger part in another reagent mixing system according to an embodiment of the present application. The actuating part 104 in the embodiment shown in fig. 2 is a second triangular protrusion 401 in the embodiment shown in fig. 4, the trigger part 105 in the embodiment shown in fig. 2 is a second arc-shaped lug 402 in the embodiment shown in fig. 4, and a spring is arranged inside the second arc-shaped lug 402. The second triangular protrusion 401 is disposed on the bottom bracket 1061, the second triangular protrusion 401 is disposed with a first positioning hole 204, the carrier tray 102 is disposed with a second positioning hole 206, the elastic element 1062 is a torsion spring 207, one end of the torsion spring 207 is fixed in the first positioning hole 204, and the other end is fixed in the second positioning hole 206. The bearing plate rotates to enable the second triangular protrusion to abut against the second arc-shaped lug, and the torsion spring is in torsional deformation, so that the first reagent bottle rotates relative to the bearing plate.

With continued reference to fig. 2, a transmission part is provided on the first reagent bottle and inside the tray, so that the first reagent bottle 103 and the tray 1061 rotate in the same direction. The transmission part on the first reagent bottle is matched with the transmission part inside the bottom support, so that the first reagent bottle can be driven by the bottom support to rotate. The transmission portion may stabilize the first reagent bottle within the mounting and transmit movement of the mounting to the first reagent bottle. In some embodiments, optionally, the transmission portion comprises: a second groove 2031 arranged along the axial direction at the side of the first reagent bottle and a triangular rib 2032 arranged at the inner side of the bottom support. The triangular rib 2032 is embedded in the second groove 2031, and when the tray 1061 rotates, the first reagent bottle 103 is driven to rotate.

With continued reference to fig. 2, the transmission portion 203 includes: a second groove 2031 is formed on the side of the first reagent bottle along the axial direction, and a triangular rib 2032 is formed on the inner side of the bottom support. The triangular rib 2032 is embedded in the second groove 2031, and drives the first reagent bottle 103 to rotate when the tray 1061 rotates. The second groove 2031 has a certain length along the axial direction, and the second groove 2031 is matched with the triangular rib 2032, so that the tray 1061 can drive the first reagent bottle 103 to rotate.

Fig. 5 is a schematic structural view of another transmission part proposed in the embodiment of the present application. As shown in fig. 5, the transmission part includes a jaw 501 provided at the bottom of the first reagent bottle 103 and a tooth 502 provided inside the collet 1061. The pawl 501 engages with the tooth 502 and rotates the first reagent bottle 103 when the tray 1061 rotates. The pawl 501 snaps into the groove between the teeth 502 and when the collet 1061 is rotated, motion is transferred to the first reagent bottle 103 by the engagement of the pawl 501 with the teeth 502.

Fig. 6 is a schematic structural diagram of another transmission part proposed in the embodiment of the present application. As shown in fig. 6, the transmission portion includes: an arc-shaped convex rib 602 arranged along the axial direction on the side surface of the first reagent bottle 103 and a tooth-shaped convex rib 601 arranged inside the bottom support 1061. The arc rib 602 is engaged with the tooth rib 601, and when the bottom support 1061 rotates, the first reagent bottle 103 is driven to rotate. The arcuate rib 602 engages with the toothed rib 601 inside the shoe 1061 so that the shoe 1061 can transmit motion to the first reagent bottle 103. In some embodiments, the arc ribs 602 may be made of an elastic material to facilitate insertion and extraction of the first reagent bottle 103.

FIG. 7 is a schematic diagram of a portion of another reagent blending system according to an embodiment of the present disclosure. As shown in fig. 7, the blending system further comprises: a card tray 701. The clamping disc 701 is arranged above the central ring 101 and connected with the bearing disc 102, and a mixing clamping position 702 is arranged at the position of the clamping disc 701 corresponding to the mixing base 106. The clamping disk 701 is connected with the power mechanism 703, the power mechanism 703 drives the clamping disk 701 to rotate, and the clamping disk 701 drives the bearing disk to rotate around the central ring. In some embodiments, optionally, the mixing detent 702 includes only the positioning hole 704, and the first reagent bottle 103 may be directly inserted into the positioning hole 704. The positioning hole can make first reagent bottle steady rotation on bearing the dish, can not influence the mixing motion of other first reagent bottles. That is, the first reagent bottle can be placed in the mixing detent, and the mixing detent is used for limiting the movement of the first reagent bottle along the circumferential direction.

With reference to fig. 2 and fig. 7, the reagent blending system further includes: kit 705, kit 705 is placed in mixing screens 702. The reagent cartridge 705 is used to carry a first reagent bottle 103, a second reagent bottle 705, and a third reagent bottle 706. It is noted that in some embodiments, the second reagent bottle 705 and the third reagent bottle 706 are integral with the cartridge body. The first reagent bottle 103 is located in the perforation 209 of the reagent cartridge and the first reagent bottle 103 can be rotated in the perforation 209.

Fig. 8 is a sectional view of a structure of a reagent cartridge according to an embodiment of the present application. As shown in fig. 8, in order to prevent the first reagent bottle 103 from moving up and down, the diameter of the first reagent bottle 103 decreases in the axial direction from the bottle mouth to the bottle bottom, and a one-way chamfer 801 is provided on the side of the first reagent bottle 103 to limit the movement of the first reagent bottle in the axial direction. The first reagent bottle 103 has a certain taper, and the one-way chamfer 801 can ensure that the first reagent bottle 103 easily penetrates through the through hole 209 of the reagent kit from top to bottom, but can ensure that the first reagent bottle 103 cannot be reversely separated from the inside of the through hole 209, thereby ensuring that the first reagent bottle 103 cannot move up and down in the reagent kit 705. In some examples, optionally, the first reagent bottle is provided with an annular structure on the side, the bottom of the annular structure is provided with a chamfer, and the upper part of the annular structure is a plane, that is, a unidirectional chamfer. When first reagent bottle passed the perforation, took place the extrusion with the bottom chamfer, first reagent bottle can get into the perforation in, but because the particularity of one-way chamfer, annular structure upper portion is the exit of plane card in the perforation below for first reagent bottle can't scurry out the perforation of kit to a certain extent.

The first reagent bottle with different diameters and the one-way chamfer angle can be prevented from being jumped when rotating.

Continuing with FIG. 7, the capture tray 701 is marked with a symbol 708. The symbol 708 is marked on a circular cover 709 protruding from the center of the detent disk. The position of symbol and the position one-to-one correspondence of mixing screens, the symbol is used for marking the position of mixing screens. In some embodiments, optionally, the symbol is an arabic numeral, the position of which is consistent with the position of the mixing card, and the symbol is used for marking the position of the mixing card.

Fig. 9 is a schematic structural diagram of another reagent blending system according to an embodiment of the present application. As shown in fig. 9, the blending system further comprises: a bin body 901, a bin cover 902, a center ring and a bearing plate are arranged in the bin body 901, and the bin cover 902 is arranged above the bin body. The bin cover 902 and the bin body 901 cooperate to prevent the environment inside the reagent blending system from being polluted.

In some embodiments, optionally, the lid 902 comprises: a first cover 9021 and a second cover 9022. The second bin cover 9022 is connected with the bin body 901, and a reagent outlet 907 corresponding to the mixing clamping position 702 is arranged on the second bin cover 9022. The reagent outlet 907 is used as an outlet for the reagent in the reagent bottle when it is sucked by the reagent needle. The second bin cover 9022 is movably connected with the first bin cover 9021, the center of the first bin cover 9021 and the circle center of the second bin cover 9022 deviate by a preset distance, and the first bin cover 9021 is arranged above the blending clamping position. When the reagent box in the reagent bin needs to be replaced, the first bin cover 9021 is only needed to be opened for replacement. Therefore, the bin body environment can not be in large-area contact with the external environment, and the external environment is prevented from polluting the inside of the system.

With reference to fig. 9, a sensor 903 is disposed on the second cover 9022, a signal emitter is disposed at a position of the first cover 9021 corresponding to the sensor 903, and the sensor 903 is used for sensing a placement state of the first cover 9021. Whether the first bin cover is accurately placed above the second bin cover or not can be determined by arranging a sensor, and the sensor can also emit a signal and prompt a worker. In some embodiments, optionally, the sensor is a hall sensor and the signal emitter is a magnetic element.

The system blending system also includes a scanner 904. A code scanner 904 is disposed outside the cartridge body 901 for scanning and reading information of the reagent cartridges. The kit is provided with a label, and the scanner can read information such as the types of reagents in the kit by scanning the label on the kit.

As shown in fig. 9, the reagent blending system further includes: a refrigeration unit 905. The refrigerating unit 905 is disposed below the cartridge body 901 for maintaining the temperature of the cartridge body 901 within a preset range. The temperature in the bin body can be kept within a preset range by utilizing the refrigeration function of the refrigeration unit. Generally, the temperature in the reagent chamber needs to be lower than the indoor temperature, so as to ensure the activity of some important components in the reagent.

In addition, reagent mixing system still includes: an air duct 906. The air duct 906 includes a fan 9061 and a baffle 9062, the baffle 9062 encloses a channel, the channel is disposed below the refrigeration unit 905, and the fan 9061 is disposed at an outlet of the channel and is configured to discharge heat generated by the refrigeration unit.

Fig. 10 is a sectional view of a portion of the structure of fig. 9. As shown in fig. 10, the reagent blending system comprises; the reagent box 705, the first reagent bottle 103, the second reagent bottle 706, the third reagent bottle 707, the center ring 101, the bearing tray 102, the bin 901, the baffle plate and the like are contained in the transmission mechanism. Wherein, drive mechanism includes: motor 1001, small pulley 1002, belt 1003, large pulley 1004, rotating sleeve 1005, and shafting 1006. The power of the motor 1001 is transmitted to the carrier plate 102 through a small pulley 1002, a belt 1003, a large pulley 1004, a shafting 1006, and a rotating sleeve 1005. Shafting 1006 is fixed on baffle 9062, and shafting 1006 both can play the effect of support to rotating sleeve 1005, can make rotating sleeve 1005 rotate around its own again, bears dish 102 and installs on rotating sleeve 1005, bears dish 102 and can rotate under rotating sleeve 1005's drive. The reagent box 705 is placed on the carrier plate 102 through the position-locking plate 701, and the reagent box 705 is driven to rotate by the rotation of the motor 1001. The refrigeration chamber 1007 and the heat preservation cover 1008 are part of the chamber 901, wherein the refrigeration chamber 1007 is fixed on the baffle 9062 through the heat insulation support 1009, the center ring 101 is installed on the refrigeration chamber 1007, so as to ensure that the center ring 101 is kept still relatively to the ground, and the heat preservation cover 1008 covers the outer surface of the refrigeration chamber 1007 to play a role in heat preservation.

The application also provides a chemiluminescence immunoassay analyzer, which comprises an incubation disc and a reagent blending system according to any one of the previous items, wherein the reagent blending system is used for providing a blended reagent for a reaction tube in the incubation disc.

In summary, the reagent mixing system provided by the embodiment of the application has a simple and compact structure, and the first reagent bottle is rotated by the contact between the action part and the trigger part, so that the reagents in the first reagent bottle are uniformly mixed. The acting force that trigger part applyed to the action part makes first reagent bottle do the variable motion, again because there is the appearance of acceleration can increase the mixing degree of reagent in the first reagent bottle, to a certain extent, can also prevent the emergence of wall built-up phenomenon. In addition, the chemiluminescence immunoassay analyzer provided with the reagent mixing system provided by the embodiment of the application can provide mixed and more uniform reagents for the test tubes in the incubation tray.

The above-described embodiments are provided for illustrative purposes only and are not intended to be limiting, and various changes and modifications may be made by those skilled in the art without departing from the scope of the present disclosure, and therefore, all equivalent technical solutions should fall within the scope of the present disclosure.

Claims (25)

1. A reagent blending system, comprising: the reagent bottle loading device comprises a center ring, a loading disc and a first reagent bottle, wherein the loading disc is arranged outside the center ring in a surrounding mode and rotates relative to the center ring.

2. The reagent blending system of claim 1, wherein the carrying plate is provided with a plurality of blending bases at intervals along a circumferential direction, and the blending bases are used for fixing the first reagent bottles on the carrying plate in a rotatable manner.

3. The reagent blending system of claim 2, wherein the blending base comprises a base support and a resilient member, wherein,

one end of the elastic element is fixedly connected with the bearing disc, the other end of the elastic element is connected with the bottom support, and the elastic element is used for enabling the bottom support to rotate in a reciprocating mode;

the base is arranged above the elastic element and connected with the bottom of the first reagent bottle, the action part is arranged on the side face of the base, and the base is used for transmitting rotary motion to the first reagent bottle.

4. The reagent blending system of claim 3, wherein the blending base further comprises a bottom support ring, the bottom support ring is fixed on the bearing disc, and a first groove is formed in the bottom support ring; the positions, corresponding to the first grooves, below the bottom support are provided with protrusions, and the protrusions are rotatably connected with the first grooves.

5. The reagent mixing system of claim 1, wherein the collision portion between the trigger portion and the action portion is made of an elastic material.

6. The reagent blending system of claim 3, wherein the actuation portion is a first arcuate lug and the trigger portion is a ball plunger;

the first arc-shaped lug is provided with a first positioning hole, the bearing disc is provided with a second positioning hole, the elastic element is a torsion spring, one end of the torsion spring is fixed in the first positioning hole, and the other end of the torsion spring is fixed in the second positioning hole;

the bearing plate rotates to enable the ball plunger to abut against the first arc-shaped lug, and the torsion spring is subjected to torsional deformation, so that the first reagent bottle rotates relative to the bearing plate.

7. The reagent blending system of claim 3, wherein the actuating portion is a first triangular protrusion, the triggering portion is a cylindrical protrusion, and a spring is disposed inside the cylindrical protrusion.

8. The reagent mixing system of claim 3, wherein the actuating portion is a second triangular protrusion, the trigger portion is a second arcuate tab, and a spring is disposed within the arcuate tab.

9. The reagent blending system of claim 3, wherein a transmission part is provided on the first reagent bottle and inside the bottom support, so that the first reagent bottle and the bottom support rotate in the same direction.

10. The reagent blending system of claim 9, wherein the transmission comprises: the second groove is formed in the side face of the first reagent bottle along the axial direction, and the triangular rib is arranged on the inner side of the bottom support;

the triangular convex ribs are embedded into the second grooves, and when the bottom support rotates, the first reagent bottle is driven to rotate.

11. The reagent blending system of claim 9, wherein the transmission comprises: the clamping jaw is arranged at the bottom of the first reagent bottle, and the convex teeth are arranged on the inner side of the bottom support;

the jack catch with the dogtooth meshing, when the collet takes place to rotate, drive first reagent bottle rotates.

12. The reagent blending system of claim 9, wherein the transmission comprises: the side surface of the first reagent bottle is provided with an arc convex rib along the axial direction and an arc convex rib arranged on the inner side of the bottom support;

the arc-shaped convex strips are meshed with the arc-shaped convex strips, and when the bottom support rotates, the first reagent bottle is driven to rotate.

13. The reagent blending system of claim 2, further comprising: the clamping disc is arranged above the center ring and connected with the bearing disc, and a mixing clamping position is arranged at the position corresponding to the mixing base.

14. The reagent blending system of claim 13, wherein the first reagent bottle is disposed in the blending detent, and the blending detent is configured to limit movement of the first reagent bottle in a circumferential direction.

15. The reagent blending system of claim 13, further comprising: the kit is positioned in the mixing clamping position and is used for bearing the first reagent bottle, the second reagent bottle and the third reagent bottle.

16. The reagent blending system of claim 15, wherein the diameter of the first reagent bottle decreases progressively from the bottle mouth to the bottle bottom in the axial direction, and a one-way chamfer is provided on the side of the first reagent bottle for limiting the movement of the first reagent bottle in the axial direction.

17. The reagent blending system of claim 15, wherein the position of the symbol corresponds to the position of the blending card one-to-one, and the symbol is used to mark the position of the blending card.

18. The reagent blending system of claim 17, further comprising: the center ring and the bearing plate are arranged in the bin body, and the bin cover is arranged above the bin body.

19. The reagent mixing system of claim 18, wherein the cover comprises a first cover and a second cover, the second cover is connected with the chamber body, the second cover is provided with a reagent outlet corresponding to the mixing block, and the reagent outlet is used for an outlet when the reagent in the reagent bottle is sucked by the reagent needle;

the first bin cover is movably connected with the second bin cover, and the center of the first bin cover deviates from the circle center of the second bin cover by a preset distance.

20. The reagent blending system of claim 19, wherein the second cover is provided with a sensor, the first cover is provided with a signal emitter at a position corresponding to the sensor, and the sensor is used for sensing the placement state of the first cover.

21. The reagent blending system of claim 20, wherein the sensor is a hall sensor and the signal emitter is a magnetic element.

22. The reagent blending system of claim 18, further comprising a code scanner disposed outside the cartridge body for scanning and reading information of the reagent cartridge.

23. The reagent blending system of claim 18, further comprising: the refrigerating unit is arranged below the bin body and used for keeping the temperature of the bin body within a preset range.

24. The reagent blending system of claim 23, further comprising: the air duct comprises a fan and a baffle, the baffle is enclosed into a channel, the channel is arranged below the refrigeration unit, and the fan is arranged at the outlet of the channel and used for discharging heat generated by the refrigeration unit.

25. A chemiluminescent immunoassay analyzer comprising an incubation tray, further comprising a reagent mixing system of any one of claims 1-24 for providing mixed reagents to reaction tubes located in the incubation tray.

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