CN211537795U

CN211537795U - Kit

Info

Publication number: CN211537795U
Application number: CN202021702242.2U
Authority: CN
Inventors: 柳建敏; 徐睿; 钟圣立; 张蕾
Original assignee: Ningbo Haiyi Biotechnology Co ltd
Current assignee: Ningbo Haiershi Intelligent Manufacturing Co ltd
Priority date: 2020-08-17
Filing date: 2020-08-17
Publication date: 2020-09-22
Anticipated expiration: 2030-08-17

Abstract

The utility model provides a kit belongs to detection and analysis equipment technical field, include: a shell, one end of which is provided with a magnetic bead reagent cavity; magnetic bead reagent bottle, its embedding magnetic bead reagent chamber can rotate for the shell, and magnetic bead reagent bottle lower extreme is provided with the pivot, and the pivot stretches out the shell and installs the gear, and magnetic bead reagent bottle is inside to be equipped with first appearance chamber, and the bottom surface along first appearance chamber upwards extends there are a plurality of stirring muscle. The utility model has the advantages of mixing is efficient.

Description

Kit

Technical Field

The utility model belongs to the technical field of the detection and analysis equipment, a kit is related to.

Background

Chemiluminescence immunoassay is an immunoassay method in which an antigen or an antibody is directly labeled with a chemiluminescent agent. In the immunoassay, the reagent generally includes a plurality of components, including a magnetic bead reagent, a labeling reagent, a diluting solution, a pretreatment solution, and other reagent components, depending on a specific analysis item. Magnetic bead reagents, also known as solid phase reagents, commonly used in heterogeneous immunoassays require that the magnetic bead reagents be in a uniform suspension state prior to sampling by the instrument.

For example, one chinese patent application No. 201820181197.7 discloses a kit comprising reagent containers including independently rotatable solid phase reagent containers and at least one homogeneous reagent container; the solid phase reagent container is also provided with a transmission part; the solid phase reagent container is characterized by comprising a reagent rack, wherein a supporting part is arranged on one side of the reagent rack, at least one notch is arranged on one side of the supporting part, a notch is arranged on the side edge of the supporting part and communicated with the notch, and the solid phase reagent container is clamped in the notch through the notch; the reagent rack is also provided with a mounting part for detachably mounting the reagent box in the immunoassay analyzer; the homogeneous reagent container is disposed in the reagent rack.

However, in the existing kit, the time for uniformly mixing the magnetic bead reagent is long, and the uniform mixing efficiency is low.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing a to there being above-mentioned problem in current technique, provide an efficient kit of mixing.

The purpose of the utility model can be realized by the following technical proposal: a kit, comprising:

a shell, one end of which is provided with a magnetic bead reagent cavity;

magnetic bead reagent bottle, its embedding magnetic bead reagent chamber can rotate for the shell, and magnetic bead reagent bottle lower extreme is provided with the pivot, and the pivot stretches out the shell and installs the gear, and magnetic bead reagent bottle is inside to be equipped with first appearance chamber, and the bottom surface along first appearance chamber upwards extends there are a plurality of stirring muscle.

As a further improvement of the utility model, a plurality of stirring ribs are annularly arranged by taking the revolving shaft of the magnetic bead reagent bottle as the center.

As a further improvement, the center of a plurality of stirring ribs arranged in a ring shape is dug downwards to form a second containing cavity, and the gap formed between any two adjacent stirring ribs is communicated with the first containing cavity and the second containing cavity.

As a further improvement of the utility model, the stirring rib is arranged at an interval with the inner side wall of the first accommodating cavity.

As a further improvement, the bottom of the magnetic bead reagent cavity is embedded with a bearing, and the bearing sleeve is arranged outside the rotating shaft.

As a further improvement, the top cover of the magnetic bead reagent cavity is provided with a sealing film, and the upper cover of the sealing film is provided with an elastic film.

As a further improvement of the utility model, a cross groove is arranged at the center of the elastic membrane.

As a further improvement of the utility model, the shell bottom is equipped with the breach that is used for installing the gear, and the gear is located shell bottom surface top with the pivot.

As a further improvement of the utility model, a first guide groove is concavely formed along the bottom surface of the shell and runs through the shell along the front-back direction.

As a further improvement of the utility model, a second guide groove is concavely formed along the bottom surface of the shell and runs through the shell along the left and right directions.

Based on the technical scheme, the embodiment of the utility model provides a can produce following technological effect at least:

1. the stirring ribs are arranged at the bottom of the magnetic bead reagent bottle, so that when the magnetic bead reagent bottle rotates, the stirring ribs can play a role in accelerating the uniform mixing, and the uniform mixing efficiency is improved;

2. the second containing cavity is dug in the center of the stirring ribs, so that the reagent needle can poke the bottom of the magnetic bead reagent bottle as far as possible to absorb more magnetic bead reagents in the process of absorbing the magnetic bead reagents, the dead space amount of the magnetic bead reagent bottle is reduced, the waste of the magnetic bead reagents is avoided, and the second containing cavity is communicated with the first containing cavity through a gap, so that the magnetic bead reagents have better fluidity during stirring and more ideal mixing effect;

3. the stirring rib and the inner side wall of the first cavity are arranged at intervals, so that the magnetic beads are prevented from being adsorbed at the joint of the stirring rib and the inner wall of the first cavity under the action of centrifugal force in the mixing process, the density of the magnetic beads after the mixing of the magnetic bead reagent is ensured, and the accuracy of a detection result is ensured.

Drawings

Fig. 1 is a perspective view of a preferred embodiment of the present invention.

Fig. 2 is a cross-sectional view of a preferred embodiment of the present invention.

Fig. 3 is a partially enlarged view at B in fig. 2.

Fig. 4 is an exploded view of fig. 1.

Fig. 5 is a partially enlarged view of a portion a in fig. 1.

Fig. 6 is a right side view of fig. 1.

In the figure, 100, the housing; 110. a magnetic bead reagent chamber; 120. a notch; 130. a first guide groove; 140. a second guide groove; 200. a magnetic bead reagent bottle; 210. a rotating shaft; 220. a first cavity; 230. stirring ribs; 240. a second cavity; 250. a gap; 300. a gear; 400. a bearing; 500. a sealing film; 600. an elastic film; 610. a cross-shaped groove.

Detailed Description

The following are specific embodiments of the present invention and the accompanying drawings are used to further describe the technical solution of the present invention, but the present invention is not limited to these embodiments.

As shown in fig. 1 to fig. 3, the kit includes a fan-shaped housing 100 and a magnetic bead reagent bottle 200, a magnetic bead reagent chamber 110 for embedding the magnetic bead reagent bottle 200 is provided at the right end of the housing 100, four conventional reagent chambers are provided at the left side of the magnetic bead reagent chamber 110, a rotating shaft 210 is provided at the lower end of the magnetic bead reagent bottle 200, the rotating shaft 210 extends downwards out of the housing 100 and is provided with a gear 300, and after the gear 300 is meshed with a driving gear of a reagent disk, the driving gear can drive the magnetic bead reagent bottle 200 to rotate in the magnetic bead reagent chamber 110.

Wherein, magnetic bead reagent bottle 200 is inside to be equipped with first appearance chamber 220, and the bottom surface along first appearance chamber 220 upwards extends has four stirring muscle 230, and when magnetic bead reagent bottle 200 rotated, stirring muscle 230 can play the effect of mixing with higher speed, and then improves mixing efficiency.

The four stirring ribs 230 are annularly arranged around the rotation axis 210 of the magnetic bead reagent bottle 200, and when the magnetic bead reagent bottle 200 rotates, the four stirring ribs 230 can rotate like a fan, so that the stirring effect is more desirable.

Further, a second cavity 240 is dug downwards at the center of the four stirring ribs 230 arranged in a ring shape, and a gap 250 formed between any two adjacent stirring ribs 230 at intervals is communicated with the first cavity 220 and the second cavity 240. Make the reagent needle can be at the in-process of drawing the magnetic bead reagent, stab the bottom of magnetic bead reagent bottle 200 as far as in order to draw more magnetic bead reagents, reduce the dead space volume of magnetic bead reagent bottle 200, avoid the waste of magnetic bead reagent, and because the second holds chamber 240 and first appearance chamber 220 and passes through clearance 250 intercommunication, the mobility when magnetic bead reagent stirs is better, and the mixing effect is more ideal.

In order to make the magnetic bead reagent bottle 200 rotate more stably and smoothly, the bearing 400 is embedded at the bottom of the magnetic bead reagent chamber 110, the bearing 400 is sleeved outside the rotating shaft 210, the bearing 400 is sealed and arranged in the magnetic bead reagent chamber 110 without being exposed, the operation is reliable, and the service life is long.

In addition, the bottom of the casing 100 is provided with a notch 120 for installing the gear 300, and the gear 300 and the rotating shaft 210 are located above the bottom surface of the casing 100, so that after the reagent kit is placed on the reagent disk, the gear 300 has enough moving space, and is not easy to interfere with the reagent disk, and the structure of the reagent kit is more compact.

As shown in fig. 4, a sealing film 500 is disposed on the top of the magnetic bead reagent chamber 110, and an elastic film 600 is disposed on the sealing film 500.

The reagent needle pierces elastic membrane 600, can suck the reagent after seal membrane 500, and the reagent needle leaves the back, and elastic membrane 600 then can rise tight seal again under self elasticity effect to avoid the reagent evaporation as far as possible, seal membrane 500 then can play the effect of sealed save after the kit canning finishes, the kit transportation of being convenient for.

The sealing film 500 may be a plastic sealing film or an aluminum foil film, and the elastic film 600 may be a silicon film or a rubber film. And four conventional reagent chambers on the housing may be provided with sealing films 500, elastic films 600.

The center of the elastic membrane 600 is formed with a cross-shaped recess 610. the cross-shaped recess 610 facilitates the insertion of a reagent needle and prevents the reagent from evaporating to the maximum.

As shown in fig. 5 to 6, a first guide groove 130 is concavely formed along the bottom surface of the housing 100, and the first guide groove 130 penetrates the housing 100 in the front-rear direction.

Be equipped with annular snap ring on the reagent dish that uses with this reagent box cooperation, the reagent box is through gomphosis from top to bottom of first guide slot 130 and snap ring, and when the reagent box rotated along with the reagent dish, first guide slot 130 kept the gomphosis state with the snap ring all the time for the reagent box can not be relative to reagent dish radial movement under the centrifugal force effect, and the installation of reagent box on the reagent dish is more reliable.

And in the position that the reagent box needs to slide in the radial direction to insert into or separate from the reagent disk, the corresponding radial direction of the snap ring is provided with a notch, and the notch can be used for the reagent box to move in the radial direction.

Two second guide grooves 140 are concavely formed along the bottom surface of the housing 100, and the two second guide grooves 140 penetrate the housing 100 in the left-right direction.

The second guide groove 140 can be matched with the guide ribs on the reagent tray to guide the reagent kit to slide radially relative to the reagent tray, and the installation position of the reagent kit on the reagent tray is more accurate and is not easy to shake.

The specific embodiments described herein are merely illustrative of the spirit of the invention. Various modifications, additions and substitutions for the specific embodiments described herein may be made by those skilled in the art without departing from the spirit of the invention or exceeding the scope of the invention as defined in the accompanying claims.

Claims

1. A kit, comprising:

a shell, one end of which is provided with a magnetic bead reagent cavity;

2. A kit according to claim 1, wherein: the plurality of stirring ribs are annularly arranged by taking the rotating shaft of the magnetic bead reagent bottle as a center.

3. A kit according to claim 2, wherein: the centers of a plurality of stirring ribs which are annularly arranged are dug downwards to form a second containing cavity, and gaps formed at intervals between any two adjacent stirring ribs are communicated with the first containing cavity and the second containing cavity.

4. A kit according to claim 2, wherein: the stirring ribs and the inner side wall of the first cavity are arranged at intervals.

5. A kit according to claim 1, wherein: and the bottom of the magnetic bead reagent cavity is embedded with a bearing, and the bearing is sleeved outside the rotating shaft.

6. A kit according to claim 1, wherein: the top of the magnetic bead reagent cavity is covered with a sealing film, and an elastic film is covered and arranged above the sealing film.

7. A kit according to claim 6, wherein: the center of the elastic membrane is provided with a cross groove.

8. A kit according to claim 1, wherein: the bottom of the shell is provided with a notch for mounting a gear, and the gear and the rotating shaft are positioned above the bottom surface of the shell.

9. A kit according to claim 1, wherein: a first guide groove is concavely formed along the bottom surface of the shell and penetrates through the shell along the front-back direction.

10. A kit according to claim 1, wherein: a second guide groove is concavely formed along the bottom surface of the shell and penetrates through the shell along the left and right directions.