CN211706798U - Reagent kit - Google Patents

Abstract

The utility model discloses a kit, include: the kit comprises a kit body, a first bottle hole and a second bottle hole are formed in the kit body, the bottom of the first bottle hole penetrates through the kit body, and an annular boss is arranged on the inner wall of the lower portion of the first bottle hole; the first reagent bottle can be rotatably inserted into the first bottle hole, and a first annular clamping plate clamped above the annular boss is arranged on the periphery of the bottom of the first reagent bottle; and a second reagent bottle inserted into the second vial hole; and a stirring paddle is arranged on the part of the bottom of the first reagent bottle, which crosses the annular boss. The reagent box of the utility model can be conveniently arranged in an in vitro diagnostic instrument with a reagent cabin mounting structure matched with the reagent box body, and is convenient to take, and the reagent box is stably mounted and positioned; the first reagent bottle can be stably arranged in the reagent box body and can smoothly rotate in the reagent box body; through bottom set up the fillet in first reagent bottle, can avoid the magnetic bead deposit at the bottom of the bottle.

Description

Reagent kit

Technical Field

The utility model relates to an in vitro diagnosis field, in particular to a kit.

Background

In an in vitro diagnostic apparatus, such as an immunochemical analyzer, a reagent kit is generally used to supply reagents such as a magnetic bead solution, an enzyme label solution, and a diluent. When the kit is used, the kit is installed in an installation structure in a reagent bin of an instrument, wherein magnetic bead liquid is stored in a magnetic bead bottle as an important reagent. The magnetic bead liquid comprises buffer liquid and magnetic beads, and whether the magnetic beads and the buffer liquid are uniformly mixed plays an important role in a detection result. Because the magnetic beads can sink to the bottom after the magnetic bead liquid is static for a long time, the magnetic bead liquid needs to be uniformly mixed before the magnetic bead liquid is used. At present, the mixing mode of magnetic bead liquid mainly has mechanical mixing and ultrasonic mixing, and the ultrasonic mixing is effectual, but the cost is too big, and can't mix all magnetic bead bottles simultaneously. Therefore, mechanical mixing methods are adopted, wherein one mechanical mixing method is realized by driving the magnetic bead bottle to rotate through a rotating mechanism, and in the method, the kit must be conveniently and firmly arranged in a reagent bin so as to conveniently load the kit into the reagent bin when in use and ensure the stability of the kit when the magnetic bead bottle rotates; to the kit, the magnetic bead bottle wherein need can stable installation in the reagent box promptly, need can rotate again to guarantee to realize the rotation mixing function to the magnetic bead bottle. However, the existing kit has some defects: reagent bottles (such as magnetic bead bottles) which need to rotate are installed in the reagent box unstably or rotate unsmoothly, and the reagent box is inconvenient to install, take and place in a reagent bin, so that a more reliable scheme is needed at present.

SUMMERY OF THE UTILITY MODEL

The utility model aims to solve the technical problem that to the not enough among the above-mentioned prior art, provide a kit.

In order to solve the technical problem, the utility model discloses a technical scheme is: a kit, comprising:

the kit comprises a kit body, a first bottle hole and a second bottle hole are formed in the kit body, the bottom of the first bottle hole penetrates through the kit body, and an annular boss is arranged on the inner wall of the lower portion of the first bottle hole;

the first reagent bottle can be rotatably inserted into the first bottle hole, a first annular clamping plate clamped above the annular boss is arranged on the periphery of the bottom of the first reagent bottle, and the outer diameter of the first annular clamping plate is smaller than the diameter of the first bottle hole and larger than the inner diameter of the annular boss;

and a second reagent bottle inserted into the second vial hole;

wherein, the bottom of the first reagent bottle is provided with a stirring paddle on the part passing over the annular boss.

Preferably, the bottom of the first annular clamping plate is provided with an annular cover with an open lower end, and the stirring paddle comprises a stirring sheet fixedly connected with the bottom of the first reagent bottle and the inner wall of the annular cover and a groove formed in the middle of the stirring sheet from bottom to top.

Preferably, the outer wall of the annular cover is provided with an oblique angle fixture block.

Preferably, the inner wall of the bottom of the first reagent bottle is connected with the inner side wall of the first reagent bottle through a fillet.

Preferably, the periphery of the upper part of the first reagent bottle is provided with a second annular clamping plate which has the same size and shape as the first annular clamping plate;

the reagent bottle comprises a first reagent bottle and is characterized in that a rubber plug is inserted into a bottle opening at the upper end of the first reagent bottle, an annular cover is arranged on the periphery of the upper end of the rubber plug, and an oblique angle is arranged on the periphery of the bottom of the rubber plug.

Preferably, the outer walls of two sides of the upper part of the kit body are symmetrically provided with bulges.

Preferably, the bottom of the kit body is provided with a cavity, and the side wall of the cavity is symmetrically provided with fixing clamping grooves;

and the outer wall of the kit body is also provided with a strip-shaped reinforcing rib.

Preferably, the upper end of the kit body is provided with a limiting plate.

Preferably, the outer wall of the second reagent bottle is provided with at least 2 third annular clamping plates, the inner wall of the second bottle hole is uniformly provided with a plurality of limiting strips arranged along the axial direction at intervals, and the upper ends of the limiting strips are provided with guide inclined planes.

Preferably, the bottom surface of the first annular clamping plate is provided with an annular groove, the section of the annular groove is in a incomplete circle with a missing lower part, a plurality of rolling balls are arranged in the annular groove, and the lower surfaces of the rolling balls are exposed out of the annular groove and are in contact with the upper surface of the annular boss.

The utility model has the advantages that:

the reagent box of the utility model can be conveniently arranged in an in vitro diagnostic instrument with a reagent cabin mounting structure matched with the reagent box body, and is convenient to take, and the reagent box is stably mounted and positioned;

the first reagent bottle of the utility model can be stably installed in the reagent box body and can smoothly rotate in the reagent box body, and the rotation of the first reagent bottle can be realized by arranging the stirring paddle and the rotating mechanism of the external instrument, so that the magnetic beads in the first reagent bottle can be fully and uniformly mixed; through bottom set up the fillet in first reagent bottle, can avoid the magnetic bead deposit at the bottom of the bottle.

Drawings

Fig. 1 is a schematic structural diagram of the kit of the present invention;

fig. 2 is a schematic structural view of the bottom of the reagent cartridge of the present invention;

fig. 3 is an exploded schematic view of a first reagent bottle of the present invention;

FIG. 4 is a schematic structural view of the stirring paddle of the present invention;

fig. 5 is an exploded view of the kit of the present invention in cooperation with a rotary gear;

fig. 6 is a schematic cross-sectional view of the kit of the present invention matching with a rotary gear;

fig. 7 is a schematic diagram of the application of the kit in an embodiment of the present invention in an immunochemical analyzer;

fig. 8 is a schematic structural diagram of the kit body of the present invention;

fig. 9 is an exploded schematic view of a second reagent bottle according to the present invention;

fig. 10 is a schematic view of a first ring clamp according to a further embodiment of the present invention.

Description of reference numerals:

1-kit body; 10-bump; 11-a cavity; 12-fixing the clamping groove; 13-strip reinforcing ribs; 14-a limiting plate;

2-first vial hole; 20-an annular boss;

3-second vial hole; 30-a limit strip; 31-a guide ramp;

4-a first reagent bottle; 40-a first annular clamping plate; 41-stirring paddle; 42-an annular shield; 43-a bevel fixture block; 44-round corner; 45-second annular snap gauge; 46-rubber plug; 410-stirring sheet; 411-a groove; 460 — an annular cover; 461-bevel angle; 400-ring groove; 401 — a ball;

5-a second reagent bottle; 50-a third annular snap-gauge;

6-immunochemical analyzer; 60, mounting grooves; 61, mounting a clamping block; 62-limiting clamping groove; 63-a rotating gear; 64-rotating the column.

Detailed Description

The present invention is further described in detail below with reference to examples so that those skilled in the art can implement the invention with reference to the description.

It will be understood that terms such as "having," "including," and "comprising," as used herein, do not preclude the presence or addition of one or more other elements or groups thereof.

As shown in fig. 1 to 9, a kit of this embodiment includes:

the kit comprises a kit body 1, wherein a first bottle hole 2 and a second bottle hole 3 are formed in the kit body 1, the bottom of the first bottle hole 2 penetrates through the kit body 1, and an annular boss 20 is arranged on the inner wall of the lower part of the first bottle hole 2;

the first reagent bottle 4 is rotatably inserted into the first bottle hole 2, a first annular clamping plate 40 clamped above the annular boss 20 is arranged on the periphery of the bottom of the first reagent bottle 4, and the outer diameter of the first annular clamping plate 40 is smaller than the diameter of the first bottle hole 2 and larger than the inner diameter of the annular boss 20;

and a second reagent bottle 5 inserted in the second bottle hole 3;

wherein, the stirring paddle 41 is arranged on the part of the bottom of the first reagent bottle 4 which crosses the annular boss 20.

The utility model discloses a kit needs can stably fix in instrument reagent storehouse to conveniently take, in order to carry out the providing of relevant reagent. Wherein, first reagent bottle 4 possesses the rotation function, and is specific: first annular cardboard 40 overlap joint is on annular boss 20 upper portion, because the external diameter of first annular cardboard 40 is between the internal diameter of annular boss 20 and the diameter of first bottled hole 2, makes first reagent bottle 4 can rotate in first bottled hole 2 internal rotation to make first reagent bottle 4 rotate under the effect of the drive apparatus in the reagent storehouse, in order to realize the stirring mixing effect to its inside reagent. The first reagent bottle 4 is used for containing reagents which need to be stirred in a rotating mode before use to be mixed evenly; the second reagent bottle 5 has no rotation function and is used for containing other reagents.

In this embodiment, this kit is arranged in automatic external diagnostic equipment (for example 6 wares of immunochemical analyzer), and first reagent bottle 4 is the magnetic bead bottle, and inside magnetic bead liquid that is equipped with needs abundant mixing and prevents the deposit during the use, and the rotational device in the reagent storehouse of 6 wares of immunochemical analyzer drives first reagent bottle 4 through stirring rake 41 and rotates and realize. The second reagent bottle 5 is used for storing enzyme solution or diluent, etc.

Specifically, in this embodiment, the reagent kit body 1 is symmetrically provided with protrusions 10 on the outer walls of two sides of the upper portion. The bottom of the kit body 1 is provided with a cavity 11, and the side wall of the cavity 11 is symmetrically provided with fixed clamping grooves 12; still be provided with bar strengthening rib 13 on the outer wall of kit body 1, bar strengthening rib 13 can avoid reagent box body shrink deformation to appear in the processing. The upper end of the kit body 1 is provided with a limiting plate 14.

In this embodiment, this kit is arranged in an immunochemical analyzer 6, refer to fig. 7, be provided with a plurality of mounting grooves 60 that are used for the installation to place the kit in this immunochemical analyzer 6's reagent storehouse, the symmetry sets up 2 installation fixture blocks 61 on the inboard open-ended bottom inner wall of mounting groove 60, has seted up spacing draw-in groove 62 on the both sides inner wall at mounting groove 60 middle part. And a rotary gear 63 is provided at the front of the inner opening of the mounting groove 60, and two rotary posts 64 are provided on the rotary gear 63. After the reagent kit of the embodiment is inserted into the mounting groove 60 from top to bottom, the mounting fixture block 61 is clamped into the fixing fixture groove 12 to prevent the reagent kit body 1 from moving horizontally; the bulges 10 on the outer walls of the two sides of the kit body 1 cross the inner wall of the mounting groove 60 on the upper part of the limiting clamping groove 62 and then are clamped into the limiting position to prevent the kit body 1 from moving up and down, and the limiting plate 14 is lapped on the upper part of the mounting groove 60, so that the kit body 1 can be fixed in the mounting groove 60. In addition, at this time, the rotating gear 63 is just under the first reagent bottle 4, the two rotating posts 64 on the rotating gear 63 are respectively arranged at two sides of the stirring blade 410 of the stirring paddle 41, and when the rotating gear 63 rotates, the first reagent bottle 4 is driven to rotate together, so that the first reagent bottle 4 is prevented from being jammed during rotation. Of course, it should be understood that the reagent cartridge of the present embodiment can be used in other instruments having the same structure of the mounting groove 60 and the rotating mechanism of the two rotating posts 64 as the above-described immunochemical analyzer 6.

Further, the bottom of the first annular clamping plate 40 is provided with an annular cover 42 with an open lower end, and the stirring paddle 41 comprises a stirring blade 410 fixedly connected with the bottom of the first reagent bottle 4 and the inner wall of the annular cover 42, and a groove 411 arranged in the middle of the stirring blade 410 from bottom to top. After the reagent box is installed in the reagent bin of the instrument, the two rotating columns 64 on the rotating gear 63 are positioned at two sides of the stirring sheet 410, so that the stirring sheet 410 can be driven to rotate through the rotation of the two rotating columns 64. The recess 411 is provided to provide a space for installing a shaft, etc. protruding upward on the rotary gear 63.

The outer wall of the annular cover 42 is provided with a bevel 461 fixture 43. The inner wall of the bevel 461 block 43 is fixedly connected to the outer wall of the annular cover 42, the upper surface thereof is a horizontal plane, the outer wall thereof is an inclined plane, and the inclined plane is inclined from top to bottom towards the outer wall of the annular cover 42. Therefore, after the first reagent bottle 4 is inserted into the first bottle hole 2, under the action of external force, the inclined surface of the outer wall of the oblique angle 461 clamping block 43 contacts with the annular boss 20, and can smoothly cross the annular boss 20 under the guidance of the inclined surface, so that the first annular clamping plate 40 is lapped on the upper surface of the annular boss 20, and therefore the first reagent bottle 4 can be rotatably arranged in the first bottle hole 2 and can not be easily pulled out upwards easily, and the first reagent bottle 4 can be prevented from falling out from the opening at the upper part in the first bottle hole 2 when the reagent kit is poured.

The bottom inner wall of the first reagent bottle 4 is connected with the inner side wall through a round angle 44, and the deposition of the magnetic beads inside the bottle bottom can be effectively avoided.

A second annular clamping plate 45 with the same size and shape as the first annular clamping plate 40 is arranged on the periphery of the upper part of the first reagent bottle 4; two piece upper and lower annular cardboard can do benefit to first reagent bottle 4 at the internal rotation of first bottleneck 2, prevent that first reagent bottle 4 from appearing the slope in first bottleneck 2.

A rubber plug 46 is inserted into the opening at the upper end of the first reagent bottle 4 to prevent the reagent in the bottle from volatilizing and leaking. The rubber stopper 46 is provided at the upper end periphery thereof with an annular cap 460 and at the bottom periphery thereof with a bevel 461. The bevel 461 is provided to facilitate the insertion of the rubber stopper 46 into the bottle mouth, and the annular cap 460 is clamped on the bottle mouth after the insertion to prevent the rubber stopper 46 from being excessively inserted.

Further, the second reagent bottle 5 also has a different rubber stopper 46 in the mouth thereof as in the first reagent bottle 4. The outer wall of the second reagent bottle 5 is provided with at least 2 third annular clamping plates 50, the inner wall of the second bottle hole 3 is evenly provided with a plurality of limiting strips 30 arranged along the axial direction at intervals, and the upper ends of the limiting strips 30 are provided with guide inclined planes 31. The stopper 30 is preferably made of a material having a certain elasticity, such as plastic. The arrangement of the guide inclined plane 31 is convenient for the second reagent bottle 5 to be inserted into the second bottle hole 3, and after the second reagent bottle 5 is inserted, the plurality of limiting strips 30 have certain pressing force on the outer wall of the second reagent bottle 5, so that the second reagent bottle 5 can be firmly installed in the second bottle hole 3 to prevent falling out.

In a further embodiment, referring to fig. 10, the bottom surface of the first annular clamping plate 40 is provided with an annular groove 400, the section of the annular groove 400 is in a truncated circle shape with a missing lower part, a plurality of rolling balls 401 are arranged in the annular groove 400, the rolling balls 401 cannot slide out, and the lower surfaces of the rolling balls 401 are exposed out of the annular groove 400 and are in contact with the upper surface of the annular boss 20. When first reagent bottle 4 rotates, first annular cardboard 40 rotates relative annular boss 20, and first annular cardboard 40 passes through spin 401 and annular boss 20's upper surface rolling contact to can reduce frictional force between the two greatly, make first reagent bottle 4's rotation more smooth and easy.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", and the like, indicate the orientation or positional relationship indicated based on the drawings, and are only for convenience of description and simplicity of description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention.

While the embodiments of the invention have been disclosed above, it is not limited to the applications listed in the description and the embodiments, which are fully applicable in all kinds of fields where the invention is suitable, and further modifications may readily be made by those skilled in the art, and the invention is therefore not limited to the specific details without departing from the general concept defined by the claims and the scope of equivalents.

Claims (10)

1. A kit, comprising:

the kit comprises a kit body, a first bottle hole and a second bottle hole are formed in the kit body, the bottom of the first bottle hole penetrates through the kit body, and an annular boss is arranged on the inner wall of the lower portion of the first bottle hole;

the first reagent bottle can be rotatably inserted into the first bottle hole, a first annular clamping plate clamped above the annular boss is arranged on the periphery of the bottom of the first reagent bottle, and the outer diameter of the first annular clamping plate is smaller than the diameter of the first bottle hole and larger than the inner diameter of the annular boss;

and a second reagent bottle inserted into the second vial hole;

wherein, the bottom of the first reagent bottle is provided with a stirring paddle on the part passing over the annular boss.

2. The kit according to claim 1, wherein the bottom of the first annular clamping plate is provided with an annular cover with an open lower end, and the stirring paddle comprises a stirring sheet fixedly connected with the bottom of the first reagent bottle and the inner wall of the annular cover and a groove arranged in the middle of the stirring sheet from bottom to top.

3. The kit according to claim 2, wherein the outer wall of the annular housing is provided with bevel dogs.

4. The reagent kit of claim 3, wherein the inner wall of the bottom of the first reagent bottle is connected with the inner wall of the first reagent bottle through a fillet.

5. The kit according to claim 2, wherein the upper periphery of the first reagent bottle is provided with a second circular clamping plate having the same size and shape as the first circular clamping plate;

the reagent bottle comprises a first reagent bottle and is characterized in that a rubber plug is inserted into a bottle opening at the upper end of the first reagent bottle, an annular cover is arranged on the periphery of the upper end of the rubber plug, and an oblique angle is arranged on the periphery of the bottom of the rubber plug.

6. The kit according to claim 1, characterized in that the upper two side outer walls of the kit body are symmetrically provided with bulges.

7. The kit according to claim 6, wherein the bottom of the kit body is provided with a cavity, and the side wall of the cavity is symmetrically provided with fixed clamping grooves;

and the outer wall of the kit body is also provided with a strip-shaped reinforcing rib.

8. The kit according to claim 7, characterized in that a limiting plate is arranged at the upper end of the kit body.

9. The kit according to claim 1, wherein the outer wall of the second reagent bottle is provided with at least 2 third annular clamping plates, the inner wall of the second bottle hole is provided with a plurality of axially arranged limiting strips at regular intervals, and the upper ends of the limiting strips are provided with guide inclined planes.

10. The kit according to claim 2, wherein the bottom surface of the first annular clamping plate is provided with an annular groove, the section of the annular groove is in a shape of a truncated circle with a missing lower part, a plurality of rolling balls are arranged in the annular groove, and the lower surfaces of the rolling balls are exposed out of the annular groove and are in contact with the upper surface of the annular boss.

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