CN114384061A - Reagent strip - Google Patents
Reagent strip Download PDFInfo
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- CN114384061A CN114384061A CN202111521708.8A CN202111521708A CN114384061A CN 114384061 A CN114384061 A CN 114384061A CN 202111521708 A CN202111521708 A CN 202111521708A CN 114384061 A CN114384061 A CN 114384061A
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- fixedly connected
- magnetic bead
- reagent strip
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
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Abstract
The invention relates to the technical field of medical detection and analysis equipment, and particularly discloses a reagent strip which comprises a reagent strip body, wherein a plurality of cleaning grooves, reagent grooves, magnetic bead holes and detection holes are fixedly formed in the reagent strip body, a through hole is fixedly formed in the reagent strip body, a sleeve is fixedly connected to the bottom of the reagent strip body and communicated with the through hole, an electric telescopic cylinder is arranged in the sleeve, a suction and discharge assembly is arranged at the top of the electric telescopic cylinder, a first spiral groove is fixedly connected to the outer wall of the electric telescopic cylinder, an annular cavity is fixedly connected to the sleeve, a transmission gear is rotatably connected to the annular cavity, a second spiral groove is fixedly connected to the inner wall of the transmission gear, a ball is rotatably connected to the second spiral groove, and one end, far away from the second spiral groove, of the ball is in rolling connection with the first spiral groove. The magnetic bead simulation device is simple in structure, and can simulate manual shaking so that magnetic beads are uniformly distributed.
Description
Technical Field
The invention relates to the technical field of medical detection and analysis equipment, in particular to a reagent strip.
Background
Carry out human sample (body fluid, cell, stool sample etc.) and detect more in vitro and go on in the reagent strip, conventional sample detection process does, dip in the human sample through straw or brush earlier and then put into current test box, then drop into corresponding reagent on to the test strip, examine through experimental apparatus at last, but realize luminous detection analysis, immunomagnetic bead need add in the measurement process, the magnetic bead is when the absorption, need guarantee that the magnetic bead can evenly distributed in the mixed liquid, after extracting, adsorb the antibody through magnetic material, combine the molecule recognition technology, can realize the mixture of sample, separation of antigen-antibody immune complex, complicated operations such as detection.
Chinese patent publication is CN 211206524U's patent document discloses a reagent strip, including the reagent strip main part, from the one end of reagent strip main part has set gradually open-top, bottom confined sample hole, tip head sheath, the magnetic sleeve hole that is used for depositing the magnetic sleeve, washing liquid storage hole, reagent hole, dilution hole, reaction hole and washing hole to the other end, the magnetic sleeve is used for adsorbing the magnetic bead and stirring, and this utility model provides a reagent strip improves the utilization ratio and the practicality of reagent strip.
However, when adding immunomagnetic beads, the stirring is usually completed through the rotating component and the vibrating component, so as to stir the mixed solution of the magnetic beads, so that the magnetic beads are in the condition of uniform distribution in the mixed solution, or the magnetic beads are in the condition of uniform distribution by manually shaking, and the manual shaking requires to shake one by one, so that the workload is large, the efficiency is low, and the mechanically driven centrifugal motion is high in efficiency, but the structure is complex and the failure rate is high.
Disclosure of Invention
The invention aims to solve the technical problems of the existing reagent strip and provides the reagent strip which does not need manual shaking, has small workload and simple structure.
The technical scheme of the invention is as follows: a reagent strip comprises a reagent strip body, wherein a plurality of cleaning grooves, reagent grooves, magnetic bead holes and detection holes are fixedly formed in the reagent strip body, a through hole is fixedly formed in the reagent strip body, a sleeve is fixedly connected to the bottom of the reagent strip body and is communicated with the through hole, an electric telescopic cylinder is arranged in the sleeve, a suction and discharge assembly is arranged at the top of the electric telescopic cylinder, a first spiral groove is fixedly connected to the outer wall of the electric telescopic cylinder, a ring cavity is fixedly connected to the sleeve, a transmission gear is rotatably connected to the ring cavity, a second spiral groove is fixedly connected to the inner wall of the transmission gear, a ball is rotatably connected to the second spiral groove, one end, away from the second spiral groove, of the ball is rotatably connected to the first spiral groove, a magnetic bead tube is erected on the magnetic bead hole, and a plurality of magnetic bead tubes are fixedly connected through a connecting frame, the magnetic bead is characterized in that a supporting rod is fixedly connected to the outer wall of the sleeve, a transmission assembly is fixedly connected to the supporting rod, the transmission assembly is connected to the transmission gear, and one end, far away from the transmission gear, of the transmission assembly is connected to the bottom of one magnetic bead. The cleaning tank is used for placing cleaning liquid, the reagent tank is used for placing reagent liquid, the magnetic bead cylinder is used for placing magnetic bead mixed liquid, the suction and discharge assembly is used for sucking and discharging liquid, the electric telescopic cylinder is used for controlling the suction and discharge assembly to reciprocate up and down so that the suction and discharge assembly can extend into a liquid layer to suck and discharge liquid, the suction and discharge assembly firstly adsorbs the reagent liquid and sends the reagent liquid into the detection cylinder in a detection hole, then the suction and discharge assembly extends into the cleaning liquid to be cleaned, after the cleaning is finished, the suction and discharge assembly extends into the magnetic bead mixed liquid and sends the magnetic bead mixed liquid into the detection cylinder so that the magnetic bead mixed liquid is combined with the reagent, after the combination is finished, a combined carrier in the detection cylinder can be detected, wherein the suction and discharge assembly has a motion process of reciprocating up and down every time when the suction and discharge assembly performs one step, in the process, a ball moves spirally in the first spiral groove and the second spiral groove, drive gear rotatory, drive gear drives a magnetic bead section of thick bamboo through drive assembly and carries out diversified rocking motion, rocking motion is distinguished from rotatory centrifugal motion, thereby the simulation is artifical to be rocked, make the magnetic bead in the magnetic bead mixed liquid evenly float on the liquid level all the time, be convenient for draw at any time of magnetic bead, simple structure just need not to carry out the operation that artifical rocked before drawing the magnetic bead, work load is less, and work efficiency is improved, the link is used for a plurality of magnetic bead section of thick bamboos synchronous motion, once can carry out the modulation that the multiunit combines the carrier.
Preferably, a plurality of first springs in an annular array are fixedly connected to the inner wall of the magnetic bead hole, one side, away from the inner wall of the magnetic bead hole, of each first spring is fixedly connected to the outer wall of the magnetic bead barrel, and a clamping ring is fixedly connected to the top of the magnetic bead barrel. The snap ring is convenient for the butt of a magnetic bead section of thick bamboo, and a magnetic bead section of thick bamboo belongs to diversified rocking motion when rocking, connects magnetic bead section of thick bamboo top port through first spring, and first spring can cushion the removal of magnetic bead section of thick bamboo top port to the position of a fixed magnetic bead section of thick bamboo that can be fine guarantees to rock the normal clear of motion.
Preferably, the transmission assembly comprises a belt, a first belt wheel and a second belt wheel, the bottom of the second belt wheel is rotatably connected with the supporting rod, a linkage gear is fixedly connected to the bottom of the first belt wheel, the first belt wheel is connected with the second belt wheel through the belt, the linkage gear is arranged in the annular cavity and is rotatably connected with the annular cavity, the linkage gear is meshed with the transmission gear, the top of the second belt wheel is rotatably connected with a turning rod, and the top of the turning rod is rotatably connected with the bottom of the magnetic bead cylinder. Drive gear is rotatory, thereby it is rotatory to drive the linkage gear, the linkage gear drives first band pulley rotatory, thereby it is rotatory to drive first band pulley through the belt, first band pulley drives the motion that the magnetic bead bobbin base portion was drawn the circle formula through the turning lever, because the diameter of magnetic bead bobbin top motion is down in the motion diameter of magnetic bead bobbin base portion, thereby make magnetic bead bobbin can take place diversified slope simultaneously, thereby effectual simulation manual work rocks the motion of magnetic bead bobbin, guarantee that the magnetic bead is in evenly distributed's the condition in the magnetic bead bobbin, for centrifugal motion, the magnetic bead is mostly in the marginal portion of mixed liquid, centrifugal motion is unable to make magnetic bead evenly distributed.
Preferably, a sliding groove and a rotating groove are fixedly formed in the annular cavity, the bottom of the transmission gear is fixedly connected with an annular wall, the annular wall is connected with the sliding groove in a sliding mode, a rotating rod is rotatably connected in the rotating groove, and the top of the rotating rod is fixedly connected with the linkage gear. The rampart slides with the spout joint, improves the rotatory stability of drive gear, and the bull stick in the bull stick can fix the linkage gear to do not influence the normal rotation of linkage gear.
Preferably, the suction assembly comprises a sliding plate, a groove is fixedly formed in the sliding plate, a connecting rod is connected in the groove in a sliding mode, a rotating seat is fixedly connected to the top of the connecting rod, a box body is fixedly connected to the top of the rotating seat, a plurality of needle tubes are fixedly connected to the bottom of the box body, a piston handle is arranged on the box body, a piston plate is arranged in the box body, and the piston handle penetrates through the box body and is fixedly connected with the piston plate. The slide is used for the linear movement of box, and the roating seat is used for the steering motion of box, and the piston handle reciprocates to can control the piston board and reciprocate, thereby the needle tubing can effectual completion suction drainage liquid's operation, can accomplish the operation that multiunit liquid was sucked drainage in step through a plurality of needle tubing, make the interval time of multiunit reaction liquid tend to the synchronization, and the reaction time in the reaction liquid tends to the synchronization, improves the accurate nature of data.
As preferred, fixedly connected with magnetic sleeve on the inspection hole, it is connected with the chassis to rotate on the periphery wall of magnetic sleeve bottom, a plurality of elastic telescopic rod that are the annular array of fixedly connected with on the chassis, the chassis below is provided with the base, elastic telescopic rod run through the chassis and with base fixed connection, the fixed mounting groove of having seted up on the base, the joint has a detection section of thick bamboo on the mounting groove, the first tooth of fixedly connected with on the base periphery wall, be provided with rotating assembly on the sleeve pipe periphery wall, rotating assembly with first tooth links to each other.
Preferably, the rotating assembly comprises a transverse plate, a sleeve plate is fixedly connected to the end portion of the transverse plate, a moving plate is connected to the sleeve plate in a sliding mode, second teeth are fixedly connected to one side wall, close to the base, of the moving plate, the moving plate is fixedly connected with symmetrically-arranged baffle plates, and a second pull ring is fixedly connected to the end portion of the moving plate; the base bottom fixedly connected with a plurality of spliced poles, a plurality of spliced poles pass through connecting plate fixed connection, the first pull ring of connecting plate tip fixedly connected with. Through a plurality of bases of first pull ring and connecting plate control downstream, thereby the base breaks away from with the chassis, a run-through hole appears, the personnel of being convenient for observe, then pull out the movable plate through the second pull ring, the movable plate is at the in-process of pulling out, the baffle forms horizontal joint with the chassis, and the second tooth is in the same place with the first tooth meshing on the base, thereby it rotates to drive the base, thereby it carries out rotary motion to drive the detection barrel on the base, the magnetic sleeve in the detection barrel outside of collocation, accomplish the process of magnetic separation, moreover, the operation is simple, it is effectual to separate, then reset the movable plate, the baffle disappears with the horizontal joint effect of base, under the effect of elastic telescopic rod, the base resets, the base is in the same place with the chassis butt, block external light source, avoid external light source to cause the influence to the testing result.
Preferably, a second spring is arranged in the elastic telescopic rod, a sealing washer is fixedly connected to the bottom of the chassis, and the chassis is abutted to the base through the sealing washer. The sealing strength of the chassis and the base in butt joint can be enhanced by the sealing washer, and the shading performance is improved.
The invention has the following beneficial effects:
the washing tank is used for placing washing liquid, the reagent tank is used for placing reagent liquid, the magnetic bead cylinder is used for placing magnetic bead mixed liquid, the suction assembly is used for sucking and discharging liquid, the electric telescopic cylinder is used for controlling the suction assembly to reciprocate up and down so that the suction assembly can stretch into a liquid layer to suck and discharge liquid, the suction assembly firstly adsorbs the reagent liquid and sends the reagent liquid into the detection cylinder in the detection hole, then the suction assembly stretches into the washing liquid to be washed, after the washing is finished, the suction assembly stretches into the magnetic bead mixed liquid and sends the magnetic bead mixed liquid into the detection cylinder so that the magnetic bead mixed liquid is combined with the reagent, after the combination is finished, a combined carrier in the detection cylinder can be detected, wherein the suction assembly has a motion process of reciprocating up and down every time when the suction assembly performs a step, and in the process, the ball moves spirally in the first spiral groove and the second spiral groove, drive gear rotatory, drive gear drives a magnetic bead section of thick bamboo through drive assembly and carries out diversified rocking motion, rocking motion is distinguished from rotatory centrifugal motion, thereby the simulation is artifical to be rocked, make the magnetic bead in the magnetic bead mixed liquid evenly float on the liquid level all the time, be convenient for draw at any time of magnetic bead, simple structure just need not to carry out the operation that artifical rocked before drawing the magnetic bead, work load is less, and work efficiency is improved, the link is used for a plurality of magnetic bead section of thick bamboos synchronous motion, once can carry out the modulation that the multiunit combines the carrier.
Drawings
FIG. 1 is a first perspective view of the overall three-dimensional structure of the present invention;
FIG. 2 is a schematic perspective view of a reagent strip body according to the present invention;
FIG. 3 is a schematic cross-sectional view of a cannula according to the present invention;
FIG. 4 is an enlarged view taken at A in FIG. 3;
FIG. 5 is a second perspective view of the overall three-dimensional structure of the present invention;
FIG. 6 is an enlarged view of FIG. 5 at B;
FIG. 7 is a schematic perspective view of a magnetic bead cartridge according to the present invention;
FIG. 8 is a schematic cross-sectional view of the housing of the present invention;
FIG. 9 is a perspective view of the suction assembly of the present invention;
FIG. 10 is a schematic cross-sectional view of the elastic extension pole of the present invention;
fig. 11 is a perspective view of the rotating assembly of the present invention.
The labels in the figures are: 100-reagent strip body; 101-a cleaning tank; 102-a reagent tank; 103-magnetic bead hole; 104-a detection well; 105-a via; 106-a cannula; 107-ring cavity; 108-a transmission gear; 109-a second helical groove; 110-a ball bearing; 111-a support bar; 112-a belt; 113-a first pulley; 114-a second pulley; 115-linked gear; 116-crank lever; 117-chute; 118-a rotary slot; 119-ring wall; 120-rotating rod; 121-magnetic sleeve; 122-a chassis; 123-elastic telescopic rod; 124-a base; 125-mounting grooves; 126-first tooth; 127-connecting column; 128-connecting plate; 129-a first tab; 130-a second spring; 200-electric telescopic cylinder; 201-a first helical groove; 300-a suction and discharge assembly; 301-a slide plate; 302-a groove; 303-a connecting rod; 304-a rotating base; 305-a box body; 306-a needle cannula; 307-piston shank; 308-a piston plate; 400-magnetic bead cylinder; 401-a connecting frame; 402-a first spring; 403-snap ring; 500-a rotating assembly; 501-a transverse plate; 502-nest plate; 503-moving the board; 504-second tooth; 505-a baffle; 506-second tab.
Detailed Description
The present invention will be further described with reference to the following examples and drawings, but the present invention is not limited thereto.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
The reagent strip shown in fig. 1 comprises a reagent strip body 100 shown in fig. 2, wherein the reagent strip body 100 is further fixedly provided with a plurality of cleaning grooves 101, reagent grooves 102, magnetic bead holes 103 and detection holes 104, the reagent strip body 100 is fixedly provided with a through hole 105, the bottom of the reagent strip body 100 is fixedly connected with a sleeve 106, the sleeve 106 is communicated with the through hole 105, the sleeve 106 is internally provided with an electric telescopic cylinder 200 shown in fig. 3, the top of the electric telescopic cylinder 200 is provided with a suction and discharge assembly 300, the outer wall of the electric telescopic cylinder 200 is fixedly connected with a first spiral groove 201, the sleeve 106 is fixedly connected with a ring cavity 107, the ring cavity 107 is rotatably connected with a transmission gear 108, the inner wall of the transmission gear 108 is fixedly connected with a second spiral groove 109, a ball 110 shown in fig. 4 is rotatably connected in the second spiral groove 109, and one end of the ball 110 far away from the second spiral groove 109 is rotatably connected with the first spiral groove 201, the magnetic bead cylinder 400 shown in fig. 7 is erected on the magnetic bead hole 103, the magnetic bead cylinders 400 are fixedly connected through a connecting frame 401, the supporting rod 111 is fixedly connected to the outer wall of the sleeve 106, the supporting rod 111 is fixedly connected with a transmission assembly, the transmission assembly is connected with the transmission gear 108, and one end of the transmission assembly, which is far away from the transmission gear 108, is connected with the bottom of one of the magnetic bead cylinders 400.
The cleaning tank 101 is used for placing cleaning solution, the reagent tank 102 is used for placing reagent solution, the magnetic bead cylinder 400 is used for placing magnetic bead mixed solution, the suction assembly 300 is used for sucking and discharging liquid, the electric telescopic cylinder 200 is used for controlling the suction assembly 300 to reciprocate up and down so that the suction assembly 300 can extend into a liquid layer to suck and discharge liquid, firstly the suction assembly 300 adsorbs the reagent solution and sends the reagent solution into the detection cylinder in the detection hole 104, then the suction assembly 300 extends into the cleaning solution to be cleaned, after the cleaning is finished, the suction assembly 300 extends into the magnetic bead mixed solution and sends the magnetic bead mixed solution into the detection cylinder so that the magnetic bead mixed solution is combined with the reagent, after the combination is finished, the combined carrier in the detection cylinder can be detected, wherein the suction assembly 300 has a motion process of reciprocating up and down when performing each step, in the process, the ball 110 moves spirally in the first spiral groove 201 and the second spiral groove 109, drive gear 108 and rotate, drive gear 108 drives a magnetic bead section of thick bamboo 400 through drive assembly and carries out diversified rocking motion, rocking motion is distinguished from rotatory centrifugal motion, thereby the simulation is artifical to be rocked, make the magnetic bead in the magnetic bead mixed liquid evenly float on the liquid level all the time, be convenient for draw at any time of magnetic bead, simple structure and need not to carry out the operation of artifical rocking before drawing the magnetic bead, improve work efficiency, link 401 is used for a plurality of magnetic bead section of thick bamboos 400 synchronous motion, once can carry out the modulation that the multiunit combines the carrier.
A plurality of first springs 402 in an annular array are fixedly connected to the inner wall of the magnetic bead hole 103, one side of the first spring 402, which is far away from the inner wall of the magnetic bead hole 103, is fixedly connected to the outer wall of the magnetic bead cylinder 400, and a snap ring 403 is fixedly connected to the top of the magnetic bead cylinder 400.
Snap ring 403 is convenient for the butt of magnetic bead section of thick bamboo 400, and magnetic bead section of thick bamboo 400 belongs to diversified rocking motion when rocking, connects magnetic bead section of thick bamboo 400 top port through first spring 402, and first spring 402 can cushion the removal of magnetic bead section of thick bamboo 400 top port to the position of fixed magnetic bead section of thick bamboo 400 that can be fine guarantees the normal clear of rocking motion.
The transmission component comprises a belt 112, a first belt wheel 113 and a second belt wheel 114, the bottom of the second belt wheel 114 is rotatably connected with a support rod 111, the bottom of the first belt wheel 113 is fixedly connected with a linkage gear 115, the first belt wheel 113 is connected with the second belt wheel 114 through the belt 112, the linkage gear 115 is arranged in the annular cavity 107 and is rotatably connected with the annular cavity, the linkage gear 115 is meshed with the transmission gear 108, the top of the second belt wheel 114 is rotatably connected with a crank rod 116 shown in fig. 6, and the top of the crank rod 116 is rotatably connected with the bottom of the magnetic bead cylinder 400.
A sliding groove 117 and a rotating groove 118 shown in fig. 5 are fixedly formed in the annular cavity 107, an annular wall 119 is fixedly connected to the bottom of the transmission gear 108, the annular wall 119 is slidably connected to the sliding groove 117, a rotating rod 120 is rotatably connected to the rotating groove 118, and the top of the rotating rod 120 is fixedly connected to the linkage gear 115.
The annular wall 119 is in sliding clamping connection with the sliding groove 117, the rotating stability of the transmission gear 108 is improved, and the rotating rod 120 in the rotating groove 118 can fix the linkage gear 115 and does not influence the normal rotation of the linkage gear 115.
The suction and exhaust assembly 300 comprises a sliding plate 301, a groove 302 shown in fig. 9 is fixedly formed in the sliding plate 301, a connecting rod 303 is slidably connected in the groove 302, a rotating seat 304 is fixedly connected to the top of the connecting rod 303, a box body 305 is fixedly connected to the top of the rotating seat 304, a plurality of needle tubes 306 are fixedly connected to the bottom of the box body 305, a piston handle 307 shown in fig. 8 is arranged on the box body 305, a piston plate 308 is arranged in the box body 305, and the piston handle 307 penetrates through the box body 305 and is fixedly connected with the piston plate 308.
The sliding plate 301 is used for linear movement of the box body 305, the rotating seat 304 is used for steering movement of the box body 305, and the piston handle 307 moves up and down, so that the piston plate 308 can be controlled to move up and down, the needle tubes 306 can effectively complete liquid suction and discharge operations, and a plurality of groups of liquid suction and discharge operations can be synchronously completed through the plurality of needle tubes 306, so that the interval time of a plurality of groups of reaction liquid tends to be synchronous, the reaction time in the reaction liquid tends to be synchronous, and the accuracy of data is improved.
Fixedly connected with magnetic sleeve 121 on inspection hole 104, it is connected with chassis 122 to rotate on the peripheral wall of magnetic sleeve 121 bottom, a plurality of elastic telescopic rod 123 that are the annular array of fixedly connected with on chassis 122, chassis 122 below is provided with base 124, elastic telescopic rod 123 run through chassis 122 and with base 124 fixed connection, the fixed mounting groove 125 of having seted up on the base 124, the joint has the detection section of thick bamboo on the mounting groove 125, the first tooth of fixedly connected with 126 on the peripheral wall of base 124, be provided with rotating assembly 500 on the peripheral wall of sleeve pipe 106, rotating assembly 500 links to each other with first tooth 126, base 124 bottom fixedly connected with spliced pole 127, a plurality of spliced poles 127 pass through connecting plate 128 fixed connection, the first pull ring 129 of connecting plate 128 tip fixedly connected with.
The rotating assembly 500 includes a horizontal plate 501, a sleeve plate 502 is fixedly connected to an end of the horizontal plate 501, a moving plate 503 is slidably connected to the sleeve plate 502, a second tooth 504 as shown in fig. 11 is fixedly connected to a side wall of the moving plate 503 close to the base 124, symmetrically arranged baffles 505 are fixedly connected to the moving plate 503, and a second pull ring 506 is fixedly connected to an end of the moving plate 503.
The plurality of pedestals 124 are controlled to move downward by the first tab 129 and the coupling plate 128, so that the base 124 is separated from the chassis 122, a through hole is formed, the observation by personnel is convenient, the moving plate 503 is then pulled out by the second pull ring 506, and during the pulling out of the moving plate 503, the baffle 505 forms a transverse snap fit with the chassis 122, and the second teeth 504 engage with the first teeth 126 on the base 124, thereby driving the base 124 to rotate, driving the detection cylinder on the base 124 to rotate, matching with the magnetic sleeve 121 outside the detection cylinder to complete the magnetic separation process, having simple operation and good separation effect, then the moving plate 503 is reset, the lateral clamping effect of the baffle 505 and the base 124 is eliminated, under the effect of elastic telescopic rod 123, base 124 resets, and base 124 and chassis 122 butt are in the same place, block external light source, avoid external light source to cause the influence to the testing result.
The second spring 130 shown in fig. 10 is arranged inside the elastic telescopic rod 123, the bottom of the chassis 122 is fixedly connected with a sealing washer, the chassis 122 abuts against the base 124 through the sealing washer, and the sealing strength of the abutting of the chassis 122 and the base 124 can be enhanced by the sealing washer, so that the shading performance is improved.
The working principle is as follows: the cleaning tank 101 is used for placing cleaning solution, the reagent tank 102 is used for placing reagent solution, the magnetic bead cylinder 400 is used for placing magnetic bead mixed solution, the suction assembly 300 is used for sucking and discharging liquid, the electric telescopic cylinder 200 is used for controlling the suction assembly 300 to reciprocate up and down so that the suction assembly 300 can extend into a liquid layer to suck and discharge liquid, firstly the suction assembly 300 adsorbs the reagent solution and sends the reagent solution into the detection cylinder in the detection hole 104, then the suction assembly 300 extends into the cleaning solution to be cleaned, after the cleaning is finished, the suction assembly 300 extends into the magnetic bead mixed solution and sends the magnetic bead mixed solution into the detection cylinder so that the magnetic bead mixed solution is combined with the reagent, after the combination is finished, the combined carrier in the detection cylinder can be detected, wherein the suction assembly 300 has a motion process of reciprocating up and down when performing each step, in the process, the ball 110 moves spirally in the first spiral groove 201 and the second spiral groove 109, drive gear 108 and rotate, drive gear 108 drives a magnetic bead section of thick bamboo 400 through drive assembly and carries out diversified rocking motion, rocking motion is distinguished from rotatory centrifugal motion, thereby the simulation is artifical to be rocked, make the magnetic bead in the magnetic bead mixed liquid evenly float on the liquid level all the time, be convenient for draw at any time of magnetic bead, simple structure and need not to carry out the operation of artifical rocking before drawing the magnetic bead, improve work efficiency, link 401 is used for a plurality of magnetic bead section of thick bamboos 400 synchronous motion, once can carry out the modulation that the multiunit combines the carrier.
The previous description is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (8)
1. A reagent strip comprising a reagent strip body (100), characterized in that: the reagent strip comprises a reagent strip body (100), and is characterized in that a plurality of cleaning grooves (101), reagent grooves (102), a magnetic bead hole (103) and a detection hole (104) are further fixedly arranged on the reagent strip body (100), a through hole (105) is fixedly arranged on the reagent strip body (100), a sleeve (106) is fixedly connected to the bottom of the reagent strip body (100), the sleeve (106) is communicated with the through hole (105), an electric telescopic cylinder (200) is arranged in the sleeve (106), a suction assembly (300) is arranged at the top of the electric telescopic cylinder (200), a first spiral groove (201) is fixedly connected to the outer wall of the electric telescopic cylinder (200), a ring cavity (107) is fixedly connected to the sleeve (106), a transmission gear (108) is rotatably connected to the ring cavity (107), a second spiral groove (109) is fixedly connected to the inner wall of the transmission gear (108), and a ball (110) is rotatably connected to the second spiral groove (109), ball (110) keep away from the one end of second helicla flute (109) with first helicla flute (201) roll connection, a magnetic bead section of thick bamboo (400) have been erect in magnetic bead hole (103), and is a plurality of a magnetic bead section of thick bamboo (400) are through link (401) fixed connection, sleeve pipe (106) outer wall fixedly connected with bracing piece (111), fixedly connected with transmission assembly on bracing piece (111), transmission assembly with drive gear (108) link to each other, transmission assembly keeps away from the one end of drive gear (108) and links to each other bottom one of them magnetic bead section of thick bamboo (400).
2. A reagent strip according to claim 1, wherein: a plurality of first springs (402) that are the annular array are fixedly connected with on magnetic bead hole (103) inner wall, one side that magnetic bead hole (103) inner wall was kept away from in first spring (402) with magnetic bead section of thick bamboo (400) outer wall fixed connection, magnetic bead section of thick bamboo (400) top fixedly connected with snap ring (403).
3. A reagent strip according to claim 1, wherein: the transmission assembly comprises a belt (112), a first belt wheel (113) and a second belt wheel (114), the bottom of the second belt wheel (114) is connected with the support rod (111) in a rotating mode, a linkage gear (115) is fixedly connected to the bottom of the first belt wheel (113), the first belt wheel (113) is connected with the second belt wheel (114) through the belt (112), the linkage gear (115) is arranged in the annular cavity (107) and is connected with the annular cavity in a rotating mode, the linkage gear (115) is connected with the transmission gear (108) in a meshing mode, the top of the second belt wheel (114) is connected with a crank rod (116) in a rotating mode, and the top of the crank rod (116) is connected with the bottom of the magnetic bead cylinder (400) in a rotating mode.
4. A reagent strip according to claim 3, wherein: the improved gear ring is characterized in that a sliding groove (117) and a rotating groove (118) are fixedly formed in the ring cavity (107), a ring wall (119) is fixedly connected to the bottom of the transmission gear (108), the ring wall (119) is in sliding connection with the sliding groove (117), a rotating rod (120) is rotatably connected to the rotating groove (118), and the top of the rotating rod (120) is fixedly connected with the linkage gear (115).
5. A reagent strip according to claim 1, wherein: inhale and arrange subassembly (300) including slide (301), fixed seting up fluted (302) in slide (301), sliding connection has connecting rod (303) in recess (302), connecting rod (303) top fixedly connected with roating seat (304), roating seat (304) top fixedly connected with box (305), a plurality of needle tubes (306) of box (305) bottom fixedly connected with, be provided with piston handle (307) on box (305), be provided with piston plate (308) in box (305), piston handle (307) run through box (305) and with piston plate (308) fixed connection.
6. A reagent strip according to claim 1, wherein: fixedly connected with magnetic sleeve (121) on inspection hole (104), rotate on magnetic sleeve (121) bottom periphery wall and be connected with chassis (122), a plurality of elastic telescopic rod (123) that are the annular array of fixedly connected with are gone up in chassis (122), chassis (122) below is provided with base (124), elastic telescopic rod (123) run through chassis (122) and with base (124) fixed connection, fixed mounting groove (125) have been seted up on base (124), the joint has a detection section of thick bamboo on mounting groove (125), the first tooth of fixedly connected with (126) on base (124) periphery wall, be provided with rotating assembly (500) on sleeve pipe (106) periphery wall, rotating assembly (500) with first tooth (126) link to each other.
7. The reagent strip of claim 6, wherein: the rotating assembly (500) comprises a transverse plate (501), the end part of the transverse plate (501) is fixedly connected with a sleeve plate (502), the sleeve plate (502) is connected with a moving plate (503) in a sliding manner, one side wall, close to the base (124), of the moving plate (503) is fixedly connected with second teeth (504), the moving plate (503) is fixedly connected with baffle plates (505) which are symmetrically arranged, and the end part of the moving plate (503) is fixedly connected with a second pull ring (506); the base (124) bottom fixedly connected with a plurality of spliced poles (127), a plurality of spliced poles (127) pass through connecting plate (128) fixed connection, connecting plate (128) tip fixedly connected with first pull ring (129).
8. The reagent strip of claim 6, wherein: the elastic telescopic rod (123) is internally provided with a second spring (130), the bottom of the chassis (122) is fixedly connected with a sealing washer, and the chassis (122) is propped against the base (124) through the sealing washer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111521708.8A CN114384061B (en) | 2021-12-13 | 2021-12-13 | Reagent strip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111521708.8A CN114384061B (en) | 2021-12-13 | 2021-12-13 | Reagent strip |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114384061A true CN114384061A (en) | 2022-04-22 |
| CN114384061B CN114384061B (en) | 2023-09-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111521708.8A Active CN114384061B (en) | 2021-12-13 | 2021-12-13 | Reagent strip |
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| Country | Link |
|---|---|
| CN (1) | CN114384061B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103235148A (en) * | 2013-04-25 | 2013-08-07 | 深圳市国赛生物技术有限公司 | Reagent disk |
| CN108159973A (en) * | 2018-01-09 | 2018-06-15 | 苏州长光华医生物医学工程有限公司 | A kind of reagent chamber structure |
| WO2021099852A1 (en) * | 2019-11-18 | 2021-05-27 | Genereach Biotechnology Corporation | Bioreactor and stirring device thereof and extraction method |
| CN113029743A (en) * | 2021-03-26 | 2021-06-25 | 河南科技大学第一附属医院 | Reagent pipe shakes even device and clinical examination uses dry-type biochemical analysis appearance |
| CN113740549A (en) * | 2021-08-27 | 2021-12-03 | 中元汇吉生物技术股份有限公司 | Reagent disk structure and sample analyzer |
-
2021
- 2021-12-13 CN CN202111521708.8A patent/CN114384061B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103235148A (en) * | 2013-04-25 | 2013-08-07 | 深圳市国赛生物技术有限公司 | Reagent disk |
| CN108159973A (en) * | 2018-01-09 | 2018-06-15 | 苏州长光华医生物医学工程有限公司 | A kind of reagent chamber structure |
| WO2021099852A1 (en) * | 2019-11-18 | 2021-05-27 | Genereach Biotechnology Corporation | Bioreactor and stirring device thereof and extraction method |
| CN113029743A (en) * | 2021-03-26 | 2021-06-25 | 河南科技大学第一附属医院 | Reagent pipe shakes even device and clinical examination uses dry-type biochemical analysis appearance |
| CN113740549A (en) * | 2021-08-27 | 2021-12-03 | 中元汇吉生物技术股份有限公司 | Reagent disk structure and sample analyzer |
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| Publication number | Publication date |
|---|---|
| CN114384061B (en) | 2023-09-12 |
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