CN112371025A - Medical laboratory test blood collection tube shaking device - Google Patents
Medical laboratory test blood collection tube shaking device Download PDFInfo
- Publication number
- CN112371025A CN112371025A CN202011305452.2A CN202011305452A CN112371025A CN 112371025 A CN112371025 A CN 112371025A CN 202011305452 A CN202011305452 A CN 202011305452A CN 112371025 A CN112371025 A CN 112371025A
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- shaking
- blood collection
- sliding frame
- sliding
- medical laboratory
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/50—Mixers with shaking, oscillating, or vibrating mechanisms with a receptacle submitted to a combination of movements, i.e. at least one vibratory or oscillatory movement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Sampling And Sample Adjustment (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a medical laboratory blood collection tube shaking device which comprises a base, wherein a sliding frame is slidably installed at the top of the base, the sliding frame is integrally of a U-shaped structure, a U-shaped opening of the sliding frame is arranged rightwards, and a conical seat is fixedly installed on the inner wall of the bottom of the sliding frame. The invention has reasonable design, compact integral structure and simple structure, but achieves unexpected use effect, can realize the left-right shaking mixing and the rotary centrifugal mixing of the blood sampling tubes and the spiral up-down lifting mixing by only utilizing the driving of the driving motor, greatly promotes the full mixing between the blood and the reagent at different positions in the blood sampling tubes, ensures the mixing to be more uniform, has higher mixing and shaking speed, can shake and mix a plurality of blood sampling tubes at one time, greatly improves the working efficiency, avoids the trouble of shaking up manually in the past, saves time and labor, and is convenient for workers to shake up and use.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a medical laboratory test blood collection tube shaking-up device.
Background
In medical blood test, blood and reagents reserved in the blood collection tube are required to be uniformly mixed after the blood collection of the blood collection tube is finished, so that the efficiency of the reagents is fully exerted, and various chemical reactions are promoted.
Traditional mixing generally adopts the handheld heparin tube of artificial mode, rock the heparin tube again repeatedly, so can let intraductal inspection reagent and blood misce bene, let blood effectively keep, this is the simplest processing mode, but when the nursing staff frequently takes a blood sample the work always, shake very easily and let the nursing staff tired out always, for example produce situations such as arm numbness, it not only lets blood sampling personnel intensity of labour sharply increase, and disposable can only carry out shaking even operation of single heparin tube usually, make shaking even inefficiency between inspection reagent and the blood mixture, can not satisfy current use needs. Therefore, the invention provides a medical laboratory blood collection tube shaking device.
Disclosure of Invention
Based on the technical problems in the background art, the invention provides a medical laboratory blood collection tube shaking device.
The invention provides a medical laboratory blood collection tube shaking device, which comprises a base, wherein a sliding frame is slidably arranged at the top of the base, the sliding frame is integrally of a U-shaped structure, a U-shaped opening of the sliding frame is arranged rightwards, a conical seat is fixedly arranged on the inner wall of the bottom of the sliding frame, a rotating seat is fixedly arranged at the top of the conical seat, a rotating rod is rotatably arranged on the rotating seat, a spiral shaking disc is fixedly sleeved on the rotating rod, a fixing mechanism is arranged on the spiral shaking disc, a plurality of blood collection tubes for placing reagents and blood are fixedly clamped and fixed on the spiral shaking disc through the fixing mechanism, a small rotating shaft is fixedly connected at the top of the rotating rod, the top of the small rotating shaft extends to the upper part of the sliding frame and is fixedly sleeved with a small gear, a vertical plate is fixedly arranged on the base on the left side of the sliding frame, a transverse rod is fixedly arranged on the right side, a rack is fixedly arranged on one side of the transverse rod close to the pinion, the pinion is meshed with the rack, linkage slide rods which are symmetrically arranged are fixedly connected on the left side of the sliding frame, the left ends of the two linkage slide bars are both slidably penetrated to the left side of the vertical plate, a linkage plate is fixedly connected between the end parts of the two linkage slide bars positioned at the left side of the vertical plate, a driving motor is fixedly arranged at the rear side of the linkage plate, an output shaft of the driving motor rotatably penetrates to the front side of the front surface of the linkage plate and is fixedly sleeved with a disc cam, the disc cam is propped against the left side of the vertical plate to be in rolling contact with the left side of the vertical plate, a plurality of extension return springs are fixedly connected between the right side of the vertical plate and the sliding frame, and a plurality of extension reset springs are all located between two linkage slide bars, the top of riser still fixedly is provided with the roof, and the top right-hand member of roof is provided with the controller, and the controller is connected with driving motor electricity.
Preferably, a plurality of heparin tubes all evenly fixed the setting on spiral shake even dish through fixed establishment.
Preferably, fixed establishment is including locating a plurality of standing grooves on the spiral even dish upper surface that shakes, and the bottom of heparin tube places in the standing groove, the standing groove is kept away from and is equipped with the through hole on one side inner wall of dwang, and the through hole internalization is provided with the locator card pole, and the one end of locator card pole extends to spiral outside and the fixedly connected with pull rod of shaking even dish, and the pull rod with spiral shake between the even dish fixedly connected with cover establish the chucking spring on the locator card pole, the one end that the pull rod was kept away from to the locator card pole extends to in the standing groove and fixes a position the heparin tube.
Preferably, the one end that the pull rod was kept away from to the locator card pole is fixed and is provided with the arc position sleeve, and the locator card pole passes through the arc position sleeve and inconsistent location with the heparin tube.
Preferably, the arc locating sleeve specifically is the rubber material, all is provided with a plurality of non-slip raised on the arc inner wall of arc locating sleeve, and non-slip raised and heparin tube antiskid cooperation.
Preferably, the inner wall of the top of the sliding frame is provided with a sleeving hole, a first bearing is fixedly sleeved in the sleeving hole, and the small rotating shaft is rotatably arranged on the first bearing; a second bearing is fixedly sleeved on the linkage plate, and an output shaft of the driving motor is rotatably arranged on the second bearing.
Preferably, the bottom of the small rotating shaft is fixedly connected with the top of the rotating rod through a flange.
Preferably, the fixed sliding block that is equipped with in bottom of sliding frame, the top of base is equipped with the sliding tray, and the sliding block along horizontal direction slidable mounting in the sliding tray.
Preferably, the vertical plate is provided with a mounting hole, a guide sliding sleeve is fixedly sleeved in the mounting hole, and the linkage sliding rod penetrates through the guide sliding sleeve in a sliding manner along the horizontal direction.
The invention has the beneficial effects that:
the medical laboratory blood collection tube shaking-up device provided by the invention is reasonable in design, compact in overall structure and simple in structure, but achieves unexpected use effect, can realize left-right shaking mixing and rotary centrifugal mixing of the blood collection tubes and spiral up-down lifting mixing by only using the driving of the driving motor, greatly promotes the sufficient mixing between blood and reagents at different positions in the blood collection tubes, enables the mixing to be more uniform and the mixing shaking-up speed to be higher, can shake up and mix a plurality of blood collection tubes at one time, greatly improves the working efficiency, avoids the trouble of manual shaking up in the past, saves time and labor, and facilitates the shaking-up use of workers.
Drawings
FIG. 1 is a schematic structural diagram of a shaking device for medical laboratory blood collection tubes according to the present invention;
FIG. 2 is a schematic view of the interior of the sliding frame according to the present invention;
FIG. 3 is a schematic view of the positioning mechanism for the blood collection tube according to the present invention;
FIG. 4 is a schematic structural view of the positioning clip rod and the arc-shaped positioning sleeve of the present invention;
FIG. 5 is a schematic side view of the driving motor and linkage plate of the present invention.
In the figure: the device comprises a base 1, a sliding frame 2, a conical seat 3, a rotating seat 4, a rotating rod 5, a spiral shaking plate 6, a placing groove 601, a pull rod 602, a clamping spring 603, a positioning clamping rod 604, an arc-shaped positioning sleeve 6041, a through hole 605, a blood sampling tube 7, a first bearing 8, a small rotating shaft 9, a pinion 10, a rack 11, a transverse rod 12, a vertical plate 13, a driving motor 14, a disc cam 15, a stretching return spring 16, a linkage plate 17, a linkage sliding rod 18, a guide sliding sleeve 19, a sliding block 20, a sliding groove 21, a second bearing 22, a top plate 23 and a controller 24.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples.
Examples
Referring to fig. 1-5, the present embodiment provides a medical laboratory blood collection tube shaking device, which comprises a base 1, a sliding frame 2 is slidably mounted on the top of the base 1, the sliding frame 2 is integrally U-shaped, a U-shaped opening of the sliding frame 2 is arranged to the right, a conical seat 3 is fixedly mounted on the inner wall of the bottom of the sliding frame 2, a rotating seat 4 is fixedly arranged on the top of the conical seat 3, a rotating rod 5 is rotatably mounted on the rotating seat 4, a spiral shaking plate 6 is fixedly sleeved on the rotating rod 5, a fixing mechanism is arranged on the spiral shaking plate 6, the spiral shaking plate 6 is fixedly clamped and fixed with a plurality of blood collection tubes 7 for placing reagents and blood through the fixing mechanism, a small rotating shaft 9 is fixedly connected to the top of the rotating rod 5, the top of the small rotating shaft 9 is rotatably extended to the upper side of the sliding frame 2 and fixedly sleeved with a pinion 10, a vertical plate 13 is fixedly mounted on the base 1 on the left, the right side fixed mounting of riser 13 has transverse bar 12, and transverse bar 12 is located the top of sliding frame 2, and one side fixed mounting that transverse bar 12 is close to pinion 10 has rack 11, and pinion 10 meshes with rack 11 mutually, the left side fixed connection of sliding frame 2 has linkage slide bar 18 that the symmetry set up, and the left end of two linkage slide bars 18 all slides and runs through to the left side of riser 13, is located fixedly connected with linkage plate 17 between the tip of two linkage slide bars 18 on the riser 13 left, the rear side fixed mounting of linkage plate 17 has driving motor 14, the output shaft of driving motor 14 rotates and runs through to the positive front side of linkage plate 17 and the fixed cover is connected with disc cam 15, disc cam 15 offsets rolling contact with the left side of riser 13, fixedly connected with a plurality of tensile reset spring 16 between the right side of riser 13 and the sliding frame 2, and a plurality of tensile reset spring 16 all are located between two linkage slide bars 18, the top of riser 13 still fixes and is provided with roof 23, and the top right-hand member of roof 23 is provided with controller 24, and controller 24 is connected with driving motor 14 electricity. The medical laboratory blood collection tube shaking-up device provided by the invention is reasonable in design, compact in overall structure and simple in structure, but achieves an unexpected use effect, can realize the left-right shaking mixing and the rotary centrifugal mixing of the blood collection tubes 7 and the spiral up-down lifting mixing only by the driving of the driving motor 14, greatly promotes the sufficient mixing between the blood and the reagent at different positions in the blood collection tubes 7, enables the mixing to be more uniform, enables the mixing shaking-up speed to be higher, can shake up and mix a plurality of blood collection tubes 7 at one time, greatly improves the working efficiency, avoids the trouble of manual shaking-up in the past, saves time and labor, and facilitates the shaking-up use of workers.
Further, a plurality of heparin tubes 7 all through fixed establishment even fixed the setting on spiral shake even dish 6.
Further, fixed establishment is including locating a plurality of standing grooves 601 on the spiral even dish 6 upper surface that shakes, and places in standing groove 601 bottom of heparin tube 7, standing groove 601 is kept away from and is equipped with through hole 605 on the one side inner wall of dwang 5, and through hole 605 internalization is provided with locator card pole 604, and the one end of locator card pole 604 extends to spiral even dish 6 outside and fixedly connected with pull rod 602 that shakes, and pull rod 602 and spiral shake between the even dish 6 fixedly connected with cover establish the chucking spring 603 on locator card pole 604, the one end that pull rod 602 was kept away from to locator card pole 604 extends to in standing groove 601 and fixes a position heparin tube 7.
Further, the fixed arc-shaped locating sleeve 6041 that is provided with of one end that the draw bar 602 is kept away from to the locator card pole 604, and the locator card pole 604 is inconsistent with the location of heparin tube 7 through arc-shaped locating sleeve 6041.
Further, arc locating sleeve 6041 specifically is the rubber material, all is provided with a plurality of non-slip raised on the arc inner wall of arc locating sleeve 6041, and non-slip raised and heparin tube 7 anti-skidding cooperation.
Furthermore, a sleeve hole is formed in the inner wall of the top of the sliding frame 2, a first bearing 8 is fixedly sleeved in the sleeve hole, and a small rotating shaft 9 is rotatably mounted on the first bearing 8; a second bearing 22 is fixedly sleeved on the linkage plate 17, and an output shaft of the driving motor 14 is rotatably mounted on the second bearing 22.
Further, the bottom of the small rotating shaft 9 is fixedly connected with the top of the rotating rod 5 through a flange.
Further, the bottom of the sliding frame 2 is fixedly provided with a sliding block 20, the top of the base 1 is provided with a sliding groove 21, and the sliding block 20 is installed in the sliding groove 21 in a sliding manner along the horizontal direction.
Furthermore, a mounting hole is formed in the vertical plate 13, a guide sliding sleeve 19 is fixedly sleeved in the mounting hole, and the linkage sliding rod 18 penetrates through the guide sliding sleeve 19 in a sliding manner along the horizontal direction.
In this embodiment, when the device is used, the blood collection tubes 7 filled with the reagent and the blood are positioned and fixed on the spiral shaking tray 6 through the positioning mechanism, that is, the positioning clamping rod 604 and the clamping spring 603 are pulled through the pull rod 602, the clamping spring 603 is stretched and deformed, then the blood collection tubes 7 are placed in the placing groove 601 on the spiral shaking tray 6, the pull rod 602 is loosened, the clamping spring 603 is reset, under the reset action of the clamping spring 603, the arc-shaped positioning sleeve 6041 at the end part of the positioning clamping rod 604 is used for positioning and fixing the blood collection tubes 7, and similarly, the plurality of blood collection tubes 7 can be positioned at each position on the spiral shaking tray 6 in the same way; then, an output shaft of a driving motor 14 is utilized to drive a disc cam 15 to rotate, because a vertical plate 13 is fixed in relative position, when the disc cam 15 rotates, the disc cam 15, a linkage plate 17 and a linkage slide rod 18 can move left and right, and simultaneously, a tension return spring 16 enables the disc cam 15 and the vertical plate 13 to be constantly contacted, so that when the linkage slide rod 18 moves left and right, the sliding frame 2 is also driven to move left and right, further, a blood sampling tube 7 on a spiral shaking and homogenizing disc 6 in the sliding frame 2 is shaken left and right, so that the shaking and mixing of blood and reagents in the blood sampling tube 7 is promoted, meanwhile, when the sliding frame 2 moves left and right, a small rotating shaft 9 and a small gear 10 also move left and right, because a rack 11 is fixed on a transverse rod 12, when the small gear 10 moves left and right, the small gear 10 is meshed with the rack 11, the pinion 10 drives the small rotating shaft 9, the rotating rod 5, the spiral shaking plate 6 and the blood sampling tubes 7 on the spiral shaking plate 6 to rotate back and forth when rotating back and forth, so that liquid in the blood sampling tubes 7 can be mixed during rotation and centrifugation, and the blood sampling tubes 7 on the spiral shaking plate 6 can be spirally lifted or spirally lowered when the spiral shaking plate 6 rotates back and forth, so that the liquid in the blood sampling tubes 7 can be mixed up and down; in conclusion, the medical laboratory blood collection tube shaking device provided by the invention is reasonable in design and compact in overall structure, achieves unexpected use effect, can realize left-right shaking mixing and rotary centrifugal mixing of the blood collection tubes 7 and spiral up-down lifting mixing only by the driving of the driving motor 14, greatly promotes the sufficient mixing between blood and reagents at different positions in the blood collection tubes 7, enables the mixing to be more uniform, enables the mixing shaking speed to be higher, can shake a plurality of blood collection tubes 7 uniformly at one time, greatly improves the working efficiency, avoids the trouble of manual shaking uniformly in the past, saves time and labor, and facilitates the shaking uniformly for workers.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (9)
1. The utility model provides a medical laboratory blood collection tube shakes even device, includes base (1), a serial communication port, the top slidable mounting of base (1) has sliding frame (2), and sliding frame (2) wholly is U type structure, the U type mouth of sliding frame (2) sets up right, fixed mounting has toper seat (3) on the bottom inner wall of sliding frame (2), the top of toper seat (3) is fixed and is provided with rotating seat (4), rotating seat (4) go up the rotatable mounting have dwang (5), the fixed cover has connect spiral even dish (6) of shaking on dwang (5), be equipped with fixed establishment on spiral even dish (6) of shaking, and spiral even dish (6) of shaking clamp through fixed establishment and are fixed with a plurality of blood collection tubes (7) that are used for placing reagent and blood, the top fixedly connected with little pivot (9) of dwang (5), the top of little pivot (9) is rotated and is extended to the top of sliding frame (2) and is fixed the cover and is connected with pinion (10), the automatic lifting device is characterized in that a vertical plate (13) is fixedly mounted on a base (1) on the left side of a sliding frame (2), a transverse rod (12) is fixedly mounted on the right side of the vertical plate (13), the transverse rod (12) is located above the sliding frame (2), a rack (11) is fixedly mounted on one side, close to a pinion (10), of the transverse rod (12), the pinion (10) is meshed with the rack (11), linkage slide rods (18) symmetrically arranged are fixedly connected to the left side of the sliding frame (2), the left ends of the two linkage slide rods (18) are slidably penetrated to the left side of the vertical plate (13), a linkage plate (17) is fixedly connected between the end portions of the two linkage slide rods (18) on the left side of the vertical plate (13), a driving motor (14) is fixedly mounted on the rear side of the linkage plate (17), an output shaft of the driving motor (14) is rotatably penetrated to the front side of the linkage plate (, the disc cam (15) is in contact with the left side of the vertical plate (13) in a propping and rolling mode, a plurality of extension reset springs (16) are fixedly connected between the right side of the vertical plate (13) and the sliding frame (2), the extension reset springs (16) are located between the two linkage sliding rods (18), a top plate (23) is fixedly arranged at the top of the vertical plate (13), a controller (24) is arranged at the right end of the top plate (23), and the controller (24) is electrically connected with the driving motor (14).
2. The shaking device for the medical laboratory blood collection tubes according to claim 1, wherein the plurality of blood collection tubes (7) are uniformly fixed on the spiral shaking plate (6) by a fixing mechanism.
3. The shaking device for medical laboratory blood collection tubes according to claim 1, the fixing mechanism comprises a plurality of placing grooves (601) arranged on the upper surface of the spiral shaking-up disc (6), the bottom of the blood sampling tube (7) is placed in a placing groove (601), a through hole (605) is arranged on the inner wall of one side of the placing groove (601) far away from the rotating rod (5), a positioning clamping rod (604) is movably arranged in the through hole (605), one end of the positioning clamping rod (604) extends to the outer part of the spiral shaking plate (6) and is fixedly connected with a pull rod (602), a clamping spring (603) sleeved on the positioning clamping rod (604) is fixedly connected between the pull rod (602) and the spiral shaking plate (6), one end of the positioning clamping rod (604) far away from the pull rod (602) extends into the placing groove (601) and positions and fixes the blood sampling tube (7).
4. The medical laboratory blood collection tube shaking device according to claim 3, wherein an arc-shaped positioning sleeve (6041) is fixedly arranged at one end of the positioning clamping rod (604) far away from the pull rod (602), and the positioning clamping rod (604) is in contact positioning with the blood collection tube (7) through the arc-shaped positioning sleeve (6041).
5. The medical laboratory blood collection tube shaking device according to claim 4, wherein the arc-shaped positioning sleeve (6041) is made of rubber, a plurality of anti-skid protrusions are arranged on the arc-shaped inner wall of the arc-shaped positioning sleeve (6041), and the anti-skid protrusions are in anti-skid fit with the blood collection tube (7).
6. The medical laboratory blood collection tube shaking device according to claim 1, wherein a sleeve hole is formed in the inner wall of the top of the sliding frame (2), a first bearing (8) is fixedly sleeved in the sleeve hole, and the small rotating shaft (9) is rotatably mounted on the first bearing (8); a second bearing (22) is fixedly sleeved on the linkage plate (17), and an output shaft of the driving motor (14) is rotatably arranged on the second bearing (22).
7. The medical laboratory blood collection tube shaking device according to claim 1, wherein the bottom of the small rotating shaft (9) is fixed to the top of the rotating rod (5) through a flange connection.
8. The medical laboratory blood collection tube shaking device according to claim 1, wherein a sliding block (20) is fixedly arranged at the bottom of the sliding frame (2), a sliding groove (21) is arranged at the top of the base (1), and the sliding block (20) is slidably installed in the sliding groove (21) along the horizontal direction.
9. The shaking device for medical laboratory test blood collection tubes according to claim 1, wherein the vertical plate (13) is provided with a mounting hole, a guiding sliding sleeve (19) is fixedly sleeved in the mounting hole, and the linking sliding rod (18) slides in a horizontal direction to penetrate through the guiding sliding sleeve (19).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011305452.2A CN112371025A (en) | 2020-11-19 | 2020-11-19 | Medical laboratory test blood collection tube shaking device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011305452.2A CN112371025A (en) | 2020-11-19 | 2020-11-19 | Medical laboratory test blood collection tube shaking device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112371025A true CN112371025A (en) | 2021-02-19 |
Family
ID=74585906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011305452.2A Withdrawn CN112371025A (en) | 2020-11-19 | 2020-11-19 | Medical laboratory test blood collection tube shaking device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112371025A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113109125A (en) * | 2021-05-18 | 2021-07-13 | 倪德望 | Blood shakes even mixed preprocessor instrument |
| CN114428129A (en) * | 2021-12-17 | 2022-05-03 | 国网湖北省电力有限公司电力科学研究院 | Degassing membrane tube assembly and online gas monitoring device in vacuum on-load tap-changer oil |
-
2020
- 2020-11-19 CN CN202011305452.2A patent/CN112371025A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113109125A (en) * | 2021-05-18 | 2021-07-13 | 倪德望 | Blood shakes even mixed preprocessor instrument |
| CN114428129A (en) * | 2021-12-17 | 2022-05-03 | 国网湖北省电力有限公司电力科学研究院 | Degassing membrane tube assembly and online gas monitoring device in vacuum on-load tap-changer oil |
| CN114428129B (en) * | 2021-12-17 | 2023-11-28 | 国网湖北省电力有限公司电力科学研究院 | Degassing membrane tube assembly and on-line monitoring device for gas in vacuum on-load tap-changer oil |
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Application publication date: 20210219 |
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| WW01 | Invention patent application withdrawn after publication |