WO2021103783A1 - Chemiluminescence immunoassay analyzer and cooling circulation system thereof, and fault monitoring method - Google Patents

Abstract

A chemiluminescence immunoassay analyzer and a cooling circulation system thereof, and a fault monitoring method. The cooling circulation system comprises: a water storage tank, a first cooling fan, a second cooling fan and Peltiers. Hot water at a hot water outlet (A1) of a reagent disk is cooled by the second cooling fan and then flows back to the reagent disk, and hot water at a hot water outlet (B1) of a magnetic bead disk enters the first cooling fan through the water storage tank for cooling and then flows back to the reagent disk. The cooling circulation system is further provided with a fault detection device for acquiring in real time the temperatures of the hot water at the hot water outlets (B1, A1) of the magnetic bead disk and the reagent disk, and the temperatures of cold water at outlets (B3, A3) of the first cooling fan and the second cooling fan, and for sending same to the fault detection device, and the fault detection device determines a fault location according to the temperature difference between the hot water and the cold water. By means of the method, a fault location of a cooling system can be checked in time, so as to solve the problem in the prior art that a fault cannot be removed in advance, causing a hidden danger to the stability of the chemiluminescence immunoassay analyzer.

Description

Chemiluminescence immune analyzer, cooling circulation system and fault monitoring method thereof Technical field

This application belongs to the technical field of medical devices, and particularly relates to a chemiluminescence immunoassay analyzer, its cooling cycle system, and a fault monitoring method.

Background technique

The chemiluminescence immunoassay analyzer is a medical testing instrument that performs immune analysis on the human body by detecting the patient’s serum. The concentration of the molecule to be tested in the sample is quantitatively analyzed according to the mathematical model established by the standard, and finally, the data report is printed to assist clinical diagnosis . The reagents and magnetic beads used in the chemiluminescence immunoassay instrument need to be stored in a low temperature environment. In order to meet the stability of measuring reagents and magnetic beads, the refrigeration system during the operation of the instrument is also the target of real-time monitoring by the manufacturer.

At present, the refrigeration system of this kind of instrument generally adopts the cooling liquid circulation to achieve the refrigeration effect. Generally, there is no monitoring to judge the cooling system failure, and it is impossible to display the error in time and eliminate the fault in advance, which brings hidden dangers to the stability of the entire instrument.

Summary of the invention

The technical problem to be solved by the present invention is to solve the problem in the prior art that the cooling circulation system has no real-time monitoring measures and cannot be eliminated in advance, which brings hidden dangers to the stability of the chemiluminescence immunoassay analyzer.

In order to solve the above technical problems, the present invention provides a chemiluminescence immunoassay analyzer, its cooling cycle system, and a fault monitoring method. The present invention uses temperature monitoring points set at the hot water outlet and cold water outlet to monitor the temperature at the temperature monitoring point. The temperature difference between water and cold water is monitored in real time. When the temperature difference exceeds the set temperature range, it is determined that the corresponding equipment of the cooling circulation system is malfunctioning, and timely troubleshooting is performed, which enhances the stability of the optical luminescence immunoassay analyzer.

The technical solutions adopted by the present invention to solve its technical problems are:

The first aspect of the present invention provides a cooling circulation system of a chemiluminescence immunoassay, including: a water storage tank, a first cooling fan, a second cooling fan, and a Peltier. The Peltier is arranged in the chemiluminescence immunoassay. In the reagent disk and magnetic bead disk of the instrument, the hot water after the Peltier heat exchange of the reagent disk flows back to the reagent disk after being cooled by the second cooling fan; the heat of the magnetic bead disk after the Peltier heat exchange The water enters the first cooling fan through the water storage tank, and then flows back to the reagent tray after being cooled by the first cooling fan, which is characterized by:

The cooling cycle system further includes a fault detection device, and the fault detection device includes a temperature acquisition device and a signal processing device;

The temperature collection device is used to collect in real time the hot water temperature signal from the magnetic bead disk and the reagent disk after the Peltier heat exchange, and the cold water temperature signal after the first cooling fan and the second cooling fan are cooled, and send them to Signal processing equipment;

The signal processing device is used for the temperature difference between the hot water flowing out of the reagent tray and the cold water cooled by the second cooling fan, and the temperature difference between the hot water flowing out of the magnetic bead tray and the cold water cooled by the first cooling fan, Determine the fault location.

Further, according to the cooling circulation system of the chemiluminescence immunoassay analyzer provided in the first aspect of the present application, if the signal processing device monitors that the temperature difference exceeds a set temperature threshold, it is determined that the cooling corresponding to the corresponding temperature monitoring point is The loop path has failed.

Further, the cooling circulation system of the chemiluminescence immunoassay analyzer provided according to the first aspect of the present application includes a first diaphragm pump and a second diaphragm pump, the inlet of the first diaphragm pump is in communication with the water storage tank, and the first diaphragm The outlet of the pump is in communication with the inlet of the first cooling fan; the inlet of the second diaphragm pump is in communication with the hot water outlet of the reagent disk, and the outlet of the second diaphragm pump is in communication with the inlet of the second cooling fan.

Further, according to the cooling circulation system of the chemiluminescence immunoassay analyzer provided in the first aspect of the present application, the temperature collection device is a temperature sensor.

Further, according to the cooling circulation system of the chemiluminescence immune analyzer provided in the first aspect of the present application, the signal processing device is a lower-level computer.

Further, according to the cooling cycle system of the chemiluminescence immunoassay analyzer provided in the first aspect of the present application, the fault detection device further includes an upper computer, the upper computer is communicatively connected with the lower computer, and the upper computer is used to receive the lower computer in real time. The temperature detection information and fault judgment information of the machine are displayed in real time.

The second aspect of the present application provides a chemiluminescence immunoassay analyzer, which includes the above-mentioned cooling circulation system.

The third aspect of the present application provides a fault monitoring method for the cooling circulation system of a chemiluminescence immunoassay analyzer, including:

(1) Set temperature monitoring points at the hot water outlet of the cooling circulation system and the cold water outlet after circulating cooling;

(2) Real-time monitoring of temperature signals at various temperature monitoring points;

(3) Determine the temperature difference between the temperature monitoring point at the hot water outlet and the temperature monitoring point at the corresponding cold water outlet;

(4) If the temperature difference exceeds the set temperature threshold, it is determined that the cooling circulation path corresponding to the corresponding temperature monitoring point is faulty.

Further, according to the failure monitoring method of the cooling circulation system provided by the third aspect of the present application, the failure location where the cooling circulation path fails includes: Peltier failure for heat exchange of cooling water, The cooling fan for cooling the hot water at the outlet is faulty, and the circulation pipeline is faulty.

The beneficial effect of the present invention is that the present invention monitors the temperature difference between the hot water and cold water at the temperature monitoring point in real time by setting the temperature monitoring points at the hot water outlet and the cold water outlet. When the temperature difference exceeds the set temperature range, the cooling is determined Corresponding equipment of the circulatory system fails, and timely investigation is carried out, which enhances the stability of the optical luminescence immunoassay analyzer.

Description of the drawings

The technical solution of the present application will be further described below with reference to the drawings and embodiments.

FIG. 1 is a schematic diagram of the structure of the cooling circulation system in an embodiment of the present application.

Detailed ways

It should be noted that the embodiments in the application and the features in the embodiments can be combined with each other if there is no conflict.

The technical solutions of the present application will be described in detail below with reference to the drawings and in conjunction with the embodiments.

Example 1

This embodiment 1 provides a cooling circulation system of a chemiluminescence immunoassay analyzer. As shown in FIG. 1, the cooling circulation system of this embodiment includes:

The water storage tank, the first cooling fan, the second cooling fan, the first diaphragm pump, the second diaphragm pump and the Peltier, wherein the cooling liquid is stored in the water storage tank, and the Peltier is set on the magnetic beads of the chemiluminescence immunoassay analyzer In the tray and the reagent tray, it is used to realize the heat exchange of the cooling liquid.

The coolant in the water storage tank is driven by the first diaphragm pump and enters the reagent tray via the first cooling fan. After the Peltier heat exchange, the coolant in the reagent tray flows out from the hot water outlet A1 and is driven by the second diaphragm pump After entering the second cooling fan and being cooled by the second cooling fan, it flows into the cold water inlet A4 of the reagent tray and the cold water inlet B2 of the magnetic bead tray through the cold water outlet A3 of the second cooling fan, respectively.

The coolant that enters the magnetic bead disk flows into the liquid storage tank from the hot water outlet B1 of the magnetic bead disk after Peltier heat exchange, and then enters the first cooling fan through the first diaphragm pump, and then enters the first cooling fan. After the hot water is cooled by the first cooling fan, it flows out from the cold water outlet B3 of the first cooling fan, and returns to the reagent tray through the cold water inlet A2 of the reagent tray. After the heat exchange by Peltier, the hot water passes through again. A1 outlet flows out, and so on.

This embodiment is equipped with a fault detection device, including temperature acquisition equipment and signal processing equipment. Among them, A1, A3, B1, and B3 are set as temperature monitoring points, and each temperature monitoring point is set with temperature acquisition equipment, which collects A1 and A1 respectively. The real-time temperature at A3, B1, and B3 are uploaded to the signal processing equipment;

The signal processing device processes and analyzes the received real-time temperature signal, and determines whether the temperature difference between A1 and A3 exceeds the set threshold range, and whether the temperature difference between B1 and B3 exceeds the set threshold range.

If the temperature difference between A1 and A3 exceeds the set threshold range, it can be determined that the cooling circulation path between A1 and A3 has failed. It may be that the second cooling fan is working abnormally, or the Peltier in the reagent tray is working Abnormal, or the circulation pipeline from A1 to A3 is faulty, causing the cooling liquid from A1 to A3 to not circulate smoothly.

If the temperature difference between B1 and B3 exceeds the set threshold range, it can be determined that the cooling circulation path between B1 and B3 has failed, which may be caused by the abnormal operation of the first cooling fan or the Peltier in the magnetic bead disk. Abnormal operation, or failure of the circulating pipelines from B1 to B3, resulting in poor circulation of the coolant from B1 to B3.

As a feasible implementation manner, the signal processing device of this embodiment may be configured as a lower-level computer, and the temperature collection device may be configured as a temperature sensor.

Further, the fault detection equipment of this embodiment further includes an upper computer, the fault detection device further includes an upper computer, the upper computer is in communication connection with the lower computer, and the upper computer is used to receive temperature detection information of the lower computer in real time, and Fault judgment information, and real-time display.

In a further embodiment, an alarm device can also be set. If a fault is detected, the alarm device can be used to give an alarm. For example, an audible and visual alarm can be used to give an alarm, which can further remind the staff to troubleshoot.

Example 2

The second embodiment provides a chemiluminescence immunoassay analyzer, which includes a cooling circulation system, and the specific structure and working principle of the cooling circulation system are the same as those in the first embodiment.

The invention monitors the temperature difference between the cold water and the hot water at the temperature monitoring point in real time by setting the temperature monitoring point. When the temperature difference exceeds the set temperature range, it is determined that the corresponding equipment of the cooling circulation system is malfunctioning, and timely investigation is performed, thereby enhancing the optics The stability of the luminescence immunoassay analyzer.

Example 3

This embodiment provides a fault monitoring method for the cooling circulation system of a chemiluminescence immune analyzer, including:

(1) Set temperature monitoring points at the hot water outlet of the cooling circulation system and the cold water outlet after circulating cooling;

(2) Real-time monitoring of temperature signals at various temperature monitoring points;

(3) Determine the temperature difference between the temperature monitoring point at the hot water outlet and the temperature monitoring point at the corresponding cold water outlet;

(4) If the temperature difference exceeds the set temperature threshold, it is determined that the cooling circulation path corresponding to the corresponding temperature monitoring point is faulty.

The monitoring system that implements the fault monitoring method of this embodiment is shown in Figure 1. A1, A3, B1, and B3 are set as temperature monitoring points, and the temperature at A1, A3, B1, and B3 is collected in real time and uploaded to the lower computer ；

The lower computer processes and analyzes the received real-time temperature signal, and judges whether the temperature difference between A1 and A3 exceeds the set threshold range, and whether the temperature difference between B1 and B3 exceeds the set threshold range.

If the temperature difference between A1 and A3 exceeds the set threshold range, it can be determined that the cooling circulation path between A1 and A3 has failed. It may be that the second cooling fan is working abnormally, or the Peltier in the reagent tray is working Abnormal, or the circulation pipeline from A1 to A3 is faulty, causing the cooling liquid from A1 to A3 to not circulate smoothly.

If the temperature difference between B1 and B3 exceeds the set threshold range, it can be determined that the cooling circulation path between B1 and B3 has failed, which may be caused by the abnormal operation of the first cooling fan or the Peltier in the magnetic bead disk. Abnormal operation, or failure of the circulating pipelines from B1 to B3, resulting in poor circulation of the coolant from B1 to B3.

The lower computer sends the real-time temperature detection information and fault judgment information to the upper computer for real-time display. After receiving the fault judgment information, the upper computer sends out an alarm signal to remind the staff to troubleshoot.

Taking the above-mentioned ideal embodiment based on this application as enlightenment, through the above description, relevant staff can make various changes and modifications without departing from the scope of the technical idea of this application. The technical scope of this application is not limited to the content in the specification, and its technical scope must be determined according to the scope of the claims.

Claims (8)

1. A cooling circulation system of a chemiluminescence immunoassay analyzer, comprising: a water storage tank, a first cooling fan, a second cooling fan, and a Peltier. The Peltier is arranged on the reagent disk and the magnetic bead disk of the chemiluminescence immunoassay analyzer Inside, the hot water after the Peltier heat exchange of the reagent disk is cooled by the second cooling fan and then flows back to the reagent disk; the hot water after the Peltier heat exchange of the magnetic bead disk enters the first cooling through the water storage tank The fan is cooled by the first cooling fan and then flows back to the reagent tray, which is characterized by:

   The cooling cycle system further includes a fault detection device, and the fault detection device includes a temperature acquisition device and a signal processing device;

   The temperature collection device is used to collect in real time the hot water temperature signal from the magnetic bead disk and the reagent disk after the Peltier heat exchange, and the cold water temperature signal after the first cooling fan and the second cooling fan are cooled, and send them to Signal processing equipment;

   The signal processing device is used for the temperature difference between the hot water flowing out of the reagent tray and the cold water cooled by the second cooling fan, and the temperature difference between the hot water flowing out of the magnetic bead tray and the cold water cooled by the first cooling fan, Determine the fault location.
2. The cooling cycle system of a chemiluminescence immunoassay analyzer according to claim 1, wherein if the signal processing device monitors that the temperature difference exceeds a set temperature threshold, it is determined that the cooling corresponding to the corresponding temperature monitoring point is The loop path has failed.
3. The cooling circulation system of a chemiluminescence immunoassay analyzer according to claim 1, wherein the temperature collection device is a temperature sensor.
4. The cooling cycle system of a chemiluminescence immunoassay analyzer according to claim 1, wherein the signal processing device is a lower-level computer.
5. The cooling cycle system of a chemiluminescence immune analyzer according to claim 4, wherein the fault detection device further comprises an upper computer, the upper computer is communicatively connected with the lower computer, and the upper computer is used to receive the lower computer in real time. The temperature detection information and fault judgment information of the machine are displayed in real time.
6. A chemiluminescence immunoassay analyzer, characterized by comprising the cooling circulation system according to any one of claims 1-5.
7. A fault monitoring method for the cooling circulation system of a chemiluminescence immune analyzer, which is characterized in that it comprises:

   (1) Set temperature monitoring points at the hot water outlet of the cooling circulation system and the cold water outlet after circulating cooling;

   (2) Real-time monitoring of temperature signals at various temperature monitoring points;

   (3) Determine the temperature difference between the temperature monitoring point at the hot water outlet and the temperature monitoring point at the corresponding cold water outlet;

   (4) If the temperature difference exceeds the set temperature threshold, it is determined that the cooling circulation path corresponding to the corresponding temperature monitoring point is faulty.
8. The fault monitoring method of the cooling circulation system of a chemiluminescence immunoassay analyzer according to claim 7, characterized in that:

   The failure locations where the cooling circulation path fails include: Peltier failure for heat exchange of cooling water, cooling fan failure for cooling hot water at the hot water outlet, and failure of the circulation pipeline.

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