CN110823878B - Chemiluminescence immunity analyzer, cooling circulation system thereof and fault monitoring method - Google Patents
Chemiluminescence immunity analyzer, cooling circulation system thereof and fault monitoring method Download PDFInfo
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- CN110823878B CN110823878B CN201911176272.6A CN201911176272A CN110823878B CN 110823878 B CN110823878 B CN 110823878B CN 201911176272 A CN201911176272 A CN 201911176272A CN 110823878 B CN110823878 B CN 110823878B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D31/00—Other cooling or freezing apparatus
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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Abstract
The application relates to a chemiluminescence immunoassay analyzer, a cooling circulation system thereof and a fault monitoring method, wherein the chemiluminescence immunoassay analyzer comprises the following steps: the hot water at the outlet of the reagent tray is cooled by the second cooling fan and then flows back to the reagent tray; hot water at the outlet of the magnetic bead disk enters a first cooling fan through a water storage tank to be cooled and then flows back to the reagent disk; the application is still further provided with a fault detection device, and the fault detection device is used for collecting the hot water temperature of the hot water outlet of the magnetic bead disk and the reagent disk and the cold water temperature of the outlet of the first cooling fan and the outlet of the second cooling fan in real time and sending the hot water temperature and the cold water temperature to the fault detection device, and the fault detection device judges the fault position according to the temperature difference value of the hot water and the cold water. The fault position of the cooling system can be checked in time, and the problem that in the prior art, faults cannot be eliminated in advance, and hidden dangers are brought to the stability of the chemiluminescence immunoassay analyzer is solved.
Description
Technical Field
The application belongs to the technical field of medical instruments, and particularly relates to a chemiluminescence immunoassay analyzer, a cooling circulation system of the chemiluminescence immunoassay analyzer and a fault monitoring method of the chemiluminescence immunoassay analyzer.
Background
The chemiluminescence immune analyzer is a medical inspection instrument for carrying out immune analysis on human bodies by detecting serum of patients, quantitatively analyzes the concentration of molecules to be detected in samples according to a mathematical model established by a standard substance, and finally prints a data report to assist clinical diagnosis. Reagents and magnetic bead portions used in the chemiluminescent immunoassay instrument need to be stored in a low-temperature environment. In order to meet the requirement of measuring the stability of reagents and magnetic beads, a refrigerating system in the operation of the instrument is also a target for real-time monitoring of a manufacturer.
At present, a refrigeration system of the instrument generally adopts cooling liquid circulation to play a refrigeration effect, generally has no monitoring to judge faults of the cooling system, cannot display errors in time and eliminate faults in advance, and brings hidden danger to the stability of the whole instrument.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: the problem of among the prior art, because do not have real time monitoring measure to cooling circulation system, can't get rid of the trouble in advance, bring the hidden danger for the stability of chemiluminescence immunoassay appearance is solved.
In order to solve the technical problems, the invention provides a chemiluminescence immunoassay analyzer, a cooling circulation system and a fault monitoring method thereof.
The technical scheme adopted by the invention for solving the technical problems is as follows:
a first aspect of the present invention provides a cooling circulation system of a chemiluminescent immunoassay analyzer, comprising: the device comprises a water storage tank, a first cooling fan, a second cooling fan and a Peltier, wherein the Peltier is arranged in a reagent disk and a magnetic bead disk of the chemiluminescence immunoassay analyzer, and hot water of the reagent disk after heat exchange of the Peltier is cooled by the second cooling fan and then flows back to the reagent disk; the hot water of magnetic bead dish after the heat exchange of Peltier gets into first cooling fan through the storage water tank to flow back to reagent dish after first cooling fan cooling, its characterized in that:
the cooling circulation system also comprises a fault detection device, and the fault detection device comprises temperature acquisition equipment and signal processing equipment;
the temperature acquisition equipment is respectively used for acquiring hot water temperature signals flowing out of the magnetic bead disk and the reagent disk after Peltier heat exchange and cold water temperature signals cooled by the first cooling fan and the second cooling fan in real time and sending the signals to the signal processing equipment;
the signal processing equipment is used for judging the fault position according to the temperature difference between the hot water flowing out of the reagent disk and the cold water cooled by the second cooling fan and the temperature difference between the hot water flowing out of the magnetic bead disk and the cold water cooled by the first cooling fan.
Further, according to the cooling circulation system of the chemiluminescence immunoassay analyzer provided by the first aspect of the present application, if the signal processing device monitors that the temperature difference exceeds the set temperature threshold, it is determined that the cooling circulation path corresponding to the corresponding temperature monitoring point is faulty.
Further, the cooling circulation system of the chemiluminescence immunoassay analyzer provided by the first aspect of the application comprises a first diaphragm pump and a second diaphragm pump, wherein an inlet of the first diaphragm pump is communicated with the water storage tank, and an outlet of the first diaphragm pump is communicated with an inlet of a first cooling fan; and the inlet of the second diaphragm pump is communicated with the hot water outlet of the reagent tray, and the outlet of the second diaphragm pump is communicated with the inlet of the second cooling fan.
Further, according to the cooling circulation system of the chemiluminescent immunoassay analyzer provided by the first aspect of the present application, the temperature collecting device is a temperature sensor.
Further, according to the cooling circulation system of the chemiluminescence immunoassay analyzer provided by the first aspect of the application, the signal processing device is a lower computer.
Further, according to the cooling circulation system of the chemiluminescence immunoassay analyzer that this application first aspect provided, the fault detection device still includes the host computer, host computer and next quick-witted communication connection, the host computer is used for receiving the temperature detection information and the fault judgement information of next quick-witted in real time to show in real time.
In a second aspect, the present application provides a chemiluminescent immunoassay analyzer comprising the cooling circulation system described above.
A third aspect of the present application provides a fault monitoring method for a cooling cycle system of a chemiluminescent immunoassay analyzer, comprising:
(1) temperature monitoring points are arranged at a hot water outlet of the cooling circulation system and a cold water outlet subjected to circulating cooling;
(2) monitoring the temperature signals of all temperature monitoring points in real time;
(3) determining the temperature difference between a temperature monitoring point at a hot water outlet and a temperature monitoring point at a corresponding cold water outlet;
(4) and if the temperature difference exceeds a set temperature threshold value, judging that the cooling circulation path corresponding to the corresponding temperature monitoring point is in fault.
Further, according to a fault monitoring method of a cooling cycle system provided in a third aspect of the present application, a fault location where a fault occurs in the cooling cycle path includes: a peltier failure for heat exchange of cooling water, a failure of a cooling fan for cooling hot water at a hot water outlet, and a failure of a circulation line.
The invention has the beneficial effects that: according to the invention, the temperature monitoring points arranged at the hot water outlet and the cold water outlet are used for monitoring the temperature difference between the hot water and the cold water at the temperature monitoring points in real time, when the temperature difference exceeds a set temperature range, the fault of the corresponding equipment of the cooling circulation system is judged and checked in time, and the stability of the optical luminescence immunoassay analyzer is enhanced.
Drawings
The technical solution of the present application is further explained below with reference to the drawings and the embodiments.
Fig. 1 is a schematic structural diagram of a cooling cycle system according to an embodiment of the present application.
Detailed Description
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.
The technical solutions of the present application will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
Example 1
This embodiment 1 provides a cooling circulation system of a chemiluminescence immunoassay analyzer, as shown in fig. 1, the cooling circulation system of this embodiment includes:
the chemical luminescence immunoassay analyzer comprises a water storage tank, a first cooling fan, a second cooling fan, a first diaphragm pump, a second diaphragm pump and a Peltier, wherein cooling liquid is stored in the water storage tank, and the Peltier is arranged in a magnetic bead disc and a reagent disc of the chemical luminescence immunoassay analyzer and used for achieving heat exchange of the cooling liquid.
The cooling liquid in the water storage tank is driven by the first diaphragm pump to enter the reagent disc through the first cooling fan, the cooling liquid in the reagent disc flows out from a hot water outlet A1 after being subjected to Peltier heat exchange, is driven by the second diaphragm pump to enter the second cooling fan, is cooled by the second cooling fan, and flows into a cold water inlet A4 of the reagent disc and a cold water inlet B2 of the magnetic bead disc through a cold water outlet A3 of the second cooling fan respectively.
The cooling liquid entering the magnetic bead disk flows into the liquid storage tank from a hot water outlet B1 of the magnetic bead disk after heat exchange of the Peltier, then enters the first cooling fan under the driving of the first diaphragm pump, the hot water entering the first cooling fan flows out from a cold water outlet B3 of the first cooling fan after being cooled by the first cooling fan, returns to the reagent disk again through a cold water inlet A2 of the reagent disk, and flows out again through an A1 port after heat exchange of the Peltier, and the process is circulated.
The fault detection device is arranged in the embodiment and comprises temperature acquisition equipment and signal processing equipment, wherein the positions A1, A3, B1 and B3 are set as temperature monitoring points, and the temperature acquisition equipment is arranged at each temperature monitoring point, respectively acquires real-time temperatures at the positions A1, A3, B1 and B3 and uploads the real-time temperatures to the signal processing equipment;
the signal processing device processes and analyzes the received real-time temperature signal, and judges whether the temperature difference between A1 and A3 exceeds a set threshold range or not, and whether the temperature difference between B1 and B3 exceeds a set threshold range or not.
If the temperature difference at A1 and A3 exceeds a set threshold range, it can be determined that a failure has occurred in the cooling circulation path between A1 to A3, which may be an abnormal operation of the second cooling fan, or an abnormal operation of the Peltier within the reagent pan, or a failure in the circulation line from A1 to A3, resulting in a poor flow of the cooling fluid from A1 to A3.
If the temperature difference between B1 and B3 exceeds a set threshold range, it may be determined that a failure has occurred in the cooling circulation path between B1 to B3, which may be an abnormal operation of the first cooling fan, or an abnormal operation of the peltier in the magnetic bead disk, or a failure in the circulation line from B1 to B3, resulting in a poor flow of the coolant from B1 to B3.
As a possible implementation, the signal processing device of the present embodiment may be configured as a lower computer, and the temperature acquisition device may be configured as a temperature sensor.
Further, the fault detection device of this embodiment still includes the host computer, the fault detection device still includes the host computer, host computer and next computer communication connection, the host computer is used for receiving the temperature detection information and the fault judgement information of next computer in real time to show in real time.
In a further embodiment, an alarm device may be further provided, and if a fault is detected, an alarm may be given through the alarm device, for example, an audible and visual alarm may be used to give an alarm, which may further remind a worker to perform troubleshooting.
Example 2
This embodiment 2 provides a chemiluminescence immunoassay analyzer, which includes a cooling circulation system, and the specific structure and the working principle of the cooling circulation system are the same as those of embodiment 1.
According to the invention, the temperature monitoring points are arranged, so that the temperature difference between the cold water and the hot water at the temperature monitoring points is monitored in real time, when the temperature difference exceeds the set temperature range, the fault of the corresponding equipment of the cooling circulation system is judged, and the fault is checked in time, so that the stability of the optical luminescence immunity analyzer is enhanced.
Example 3
The embodiment provides a fault monitoring method for a cooling circulation system of a chemiluminescence immunoassay analyzer, which comprises the following steps:
(1) temperature monitoring points are arranged at a hot water outlet of the cooling circulation system and a cold water outlet subjected to circulating cooling;
(2) monitoring the temperature signals of all temperature monitoring points in real time;
(3) determining the temperature difference between a temperature monitoring point at a hot water outlet and a temperature monitoring point at a corresponding cold water outlet;
(4) and if the temperature difference exceeds a set temperature threshold value, judging that the cooling circulation path corresponding to the corresponding temperature monitoring point is in fault.
As shown in fig. 1, in the monitoring system for implementing the fault monitoring method of the embodiment, temperature monitoring points are set at positions a1, A3, B1 and B3, and are used for acquiring temperatures at positions a1, A3, B1 and B3 in real time and uploading the temperatures to a lower computer;
the lower computer processes and analyzes the received real-time temperature signals, and judges whether the temperature difference between A1 and A3 exceeds a set threshold range or not, and whether the temperature difference between B1 and B3 exceeds a set threshold range or not.
If the temperature difference at A1 and A3 exceeds a set threshold range, it can be determined that a failure has occurred in the cooling circulation path between A1 to A3, which may be an abnormal operation of the second cooling fan, or an abnormal operation of the Peltier within the reagent pan, or a failure in the circulation line from A1 to A3, resulting in a poor flow of the cooling fluid from A1 to A3.
If the temperature difference between B1 and B3 exceeds a set threshold range, it may be determined that a failure has occurred in the cooling circulation path between B1 to B3, which may be an abnormal operation of the first cooling fan, or an abnormal operation of the peltier in the magnetic bead disk, or a failure in the circulation line from B1 to B3, resulting in a poor flow of the coolant from B1 to B3.
The lower computer sends real-time temperature detection information and fault judgment information to the upper computer for real-time display, and the upper computer sends out an alarm signal after receiving the fault judgment information so as to remind a worker to carry out troubleshooting.
In light of the foregoing description of the preferred embodiments according to the present application, it is to be understood that various changes and modifications may be made without departing from the spirit and scope of the invention. The technical scope of the present application is not limited to the contents of the specification, and must be determined according to the scope of the claims.
Claims (8)
1. A cooling circulation system of a chemiluminescent immunoassay analyzer comprising: the device comprises a water storage tank, a first cooling fan, a second cooling fan and a Peltier, wherein the Peltier is arranged in a reagent disk and a magnetic bead disk of the chemiluminescence immunoassay analyzer, and hot water of the reagent disk after heat exchange of the Peltier is cooled by the second cooling fan and then flows back to the reagent disk; the hot water of magnetic bead dish after the heat exchange of Peltier gets into first cooling fan through the storage water tank to flow back to reagent dish after first cooling fan cooling, its characterized in that:
the cooling circulation system also comprises a fault detection device, and the fault detection device comprises temperature acquisition equipment and signal processing equipment;
the temperature acquisition equipment is respectively used for acquiring hot water temperature signals flowing out of the magnetic bead disk and the reagent disk after Peltier heat exchange and cold water temperature signals cooled by the first cooling fan and the second cooling fan in real time and sending the signals to the signal processing equipment;
the signal processing equipment is used for judging the fault position according to the temperature difference between the hot water flowing out of the reagent disk and the cold water cooled by the second cooling fan and the temperature difference between the hot water flowing out of the magnetic bead disk and the cold water cooled by the first cooling fan.
2. The cooling circulation system of a chemiluminescent immunoassay analyzer of claim 1, wherein if the signal processing device monitors that the temperature difference exceeds a set temperature threshold, it is determined that the cooling circulation path corresponding to the corresponding temperature monitoring point is failed.
3. The cooling circulation system of the chemiluminescent immunoassay analyzer of claim 1 wherein the temperature collection device is a temperature sensor.
4. The cooling circulation system of the chemiluminescent immunoassay analyzer of claim 1 wherein the signal processing device is a lower computer.
5. The cooling circulation system of the chemiluminescence immunoassay analyzer of claim 4, wherein the fault detection device further comprises an upper computer, the upper computer is in communication connection with the lower computer, and the upper computer is used for receiving the temperature detection information and the fault judgment information of the lower computer in real time and displaying the temperature detection information and the fault judgment information in real time.
6. A chemiluminescent immunoassay analyzer comprising a cooling circuit according to any one of claims 1 to 5.
7. A fault monitoring method of a cooling circulation system of a chemiluminescence immunoassay analyzer is characterized by comprising the following steps:
(1) temperature monitoring points are arranged at a hot water outlet of the cooling circulation system and a cold water outlet subjected to circulating cooling;
(2) monitoring the temperature signals of all temperature monitoring points in real time;
(3) determining the temperature difference between a temperature monitoring point at a hot water outlet and a temperature monitoring point at a corresponding cold water outlet;
(4) if the temperature difference exceeds a set temperature threshold, judging that the cooling circulation path corresponding to the corresponding temperature monitoring point is in fault;
wherein, the cooling circulation system of the chemiluminescence immunoassay analyzer comprises: the device comprises a water storage tank, a first cooling fan, a second cooling fan and a Peltier, wherein the Peltier is arranged in a reagent disk and a magnetic bead disk of the chemiluminescence immunoassay analyzer, and hot water of the reagent disk after heat exchange of the Peltier is cooled by the second cooling fan and then flows back to the reagent disk; hot water of the magnetic bead plate after heat exchange through the Peltier enters a first cooling fan through a water storage tank, is cooled by the first cooling fan and then flows back to the reagent plate;
the temperature signals of the temperature monitoring points in the step (2) are hot water temperature signals flowing out of the magnetic bead disc and the reagent disc after heat exchange through Peltier and cold water temperature signals cooled by the first cooling fan and the second cooling fan;
the temperature difference in the step (3) refers to a temperature difference between hot water flowing out of the reagent tray and cold water cooled by the second cooling fan, and a temperature difference between hot water flowing out of the magnetic bead tray and cold water cooled by the first cooling fan.
8. The method for monitoring a failure of a cooling cycle system of a chemiluminescent immunoassay analyzer of claim 7,
the fault location where the cooling circulation path is faulty includes: a peltier failure for heat exchange of cooling water, a failure of a cooling fan for cooling hot water at a hot water outlet, and a failure of a circulation line.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911176272.6A CN110823878B (en) | 2019-11-26 | 2019-11-26 | Chemiluminescence immunity analyzer, cooling circulation system thereof and fault monitoring method |
| PCT/CN2020/116847 WO2021103783A1 (en) | 2019-11-26 | 2020-09-22 | Chemiluminescence immunoassay analyzer and cooling circulation system thereof, and fault monitoring method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201911176272.6A CN110823878B (en) | 2019-11-26 | 2019-11-26 | Chemiluminescence immunity analyzer, cooling circulation system thereof and fault monitoring method |
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| CN110823878A CN110823878A (en) | 2020-02-21 |
| CN110823878B true CN110823878B (en) | 2021-04-23 |
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| CN110823878B (en) * | 2019-11-26 | 2021-04-23 | 苏州长光华医生物医学工程有限公司 | Chemiluminescence immunity analyzer, cooling circulation system thereof and fault monitoring method |
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| CN110823878B (en) * | 2019-11-26 | 2021-04-23 | 苏州长光华医生物医学工程有限公司 | Chemiluminescence immunity analyzer, cooling circulation system thereof and fault monitoring method |
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2019
- 2019-11-26 CN CN201911176272.6A patent/CN110823878B/en active Active
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| CN201917154U (en) * | 2010-12-14 | 2011-08-03 | 孙勇 | Cooling-water machine used for cooling recirculated water of medical equipment |
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| WO2021103783A1 (en) | 2021-06-03 |
| CN110823878A (en) | 2020-02-21 |
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