CN112763733A - Reagent management device - Google Patents
Reagent management device Download PDFInfo
- Publication number
- CN112763733A CN112763733A CN202011583247.2A CN202011583247A CN112763733A CN 112763733 A CN112763733 A CN 112763733A CN 202011583247 A CN202011583247 A CN 202011583247A CN 112763733 A CN112763733 A CN 112763733A
- Authority
- CN
- China
- Prior art keywords
- reagent
- mode
- module
- power module
- pot
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 314
- 238000012360 testing method Methods 0.000 claims abstract description 70
- 230000001960 triggered effect Effects 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 15
- 238000004891 communication Methods 0.000 claims abstract description 5
- 238000002347 injection Methods 0.000 claims description 28
- 239000007924 injection Substances 0.000 claims description 28
- 238000002156 mixing Methods 0.000 claims description 28
- 238000001514 detection method Methods 0.000 claims description 27
- 238000005057 refrigeration Methods 0.000 claims description 25
- 230000005540 biological transmission Effects 0.000 claims description 18
- 230000017525 heat dissipation Effects 0.000 claims description 18
- 238000001816 cooling Methods 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 230000007246 mechanism Effects 0.000 claims description 9
- 238000012806 monitoring device Methods 0.000 claims description 9
- 238000012544 monitoring process Methods 0.000 claims description 3
- 238000004898 kneading Methods 0.000 claims description 2
- 230000008859 change Effects 0.000 abstract description 3
- 239000011324 bead Substances 0.000 description 11
- 230000009471 action Effects 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 239000011810 insulating material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000004397 blinking Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a reagent management device, comprising: the reagent pot is internally provided with a reagent plate which is driven by the power module to rotate; and the control device is in communication connection with the power module and comprises a trigger module. The use mode of the reagent management device comprises a test mode, a countdown mode and a reagent replacement mode, wherein the test mode comprises a test execution mode, the use mode is switched to the countdown mode when the trigger module is triggered in the test execution mode, and the use mode is automatically switched to the reagent replacement mode after the countdown mode keeps the preset countdown duration. Under test mode and count down mode, controlling means control power module according to the automatic operation of settlement procedure, under the change reagent mode, power module enters manual control mode. Based on the setting of the countdown mode, the adaptability of the reagent pot with other equipment is improved when the reagent pot operates, unnecessary loss of a machine can be reduced, reagents can be saved, and time can be saved.
Description
Technical Field
The invention relates to the technical field of in-vitro diagnosis equipment, in particular to a reagent management device.
Background
In the field of in vitro diagnosis, a reagent pan needs to be matched with devices such as a sample injection assembly and the like to complete the whole actual detection process. However, at present, the matching between some reagent pots and other matching devices is poor, and when the reagent pot enters the reagent replacement mode, other matching devices may not have time to perform actions corresponding to the reagent replacement mode, which affects the test progress.
Therefore, how to improve the adaptability of the reagent pot to other devices during operation is a technical problem to be solved by those skilled in the art.
Disclosure of Invention
In view of the above, an object of the present invention is to provide a reagent management apparatus which is improved in adaptability to other devices during operation.
In order to achieve the purpose, the invention provides the following technical scheme:
a reagent management device comprising:
the reagent pot is internally provided with a reagent tray which is driven by the power module to rotate;
the control device is in communication connection with the power module and comprises a trigger module;
the using mode of the reagent management device comprises a testing mode, a countdown mode and a reagent replacing mode, wherein the testing mode comprises a testing proceeding mode, the using mode is switched to the countdown mode when the triggering module is triggered in the testing proceeding mode, and the using mode is automatically switched to the reagent replacing mode after the countdown mode keeps a preset countdown duration;
the control device controls the power module to automatically run according to a set program in the test execution mode and the countdown mode, and the power module enters the manual control mode in the reagent replacement mode.
Preferably, in the countdown mode, when the trigger module is triggered, the use mode is switched back to the test execution mode.
Preferably, the reagent pot is provided with a movable disk cover capable of being opened and closed and a disk cover monitoring device for monitoring the opening and closing state of the movable disk cover;
in the reagent replacement mode, when the trigger module is triggered:
if the disc cover monitoring device monitors that the movable disc cover is in a covering state, the control device switches the use mode to the test mode;
if the tray cover monitoring device monitors that the movable tray cover is in an open state, the control device controls the power module to drive the reagent tray to rotate by a preset replacement angle.
Preferably, the reagent tray is provided with reagent positions for installing reagent boxes, and the reagent pot is provided with an information reading and writing device;
the test mode further comprises a scan mode performed before the test proceeding mode;
in the tray scanning mode, the power module drives the reagent tray to rotate, the information reading and writing device sequentially reads reagent information on the reagent kit moving to the reading range of the information reading and writing device and can write the read information into the control device.
Preferably, the reagent pot is further provided with a leak detection sensor, and the leak detection sensor is used for detecting each reagent position to determine whether a reagent box is installed on the reagent pot;
and the information reading-writing device is started when the reagent position provided with the reagent kit moves to the reading range of the reagent position according to the detection result of the leak detection sensor, and reads and/or writes corresponding reagent information on the reagent kit.
Preferably, at least two reagent sites are uniformly arranged on the reagent tray along the circumferential direction;
the leak detection sensor and the information read-write device are sequentially fixed on the inner side wall of the reagent pot along the circumferential direction, and the reagent position in the detection range of the leak detection sensor and the reagent position in the reading range of the information read-write device are adjacent along the circumferential direction.
Preferably, a mixing transmission mechanism is arranged between the bottle to be mixed in the reagent kit and the reagent pot, so that when the reagent disk rotates, the mixing transmission mechanism drives the bottle to be mixed to rotate on the reagent disk.
Preferably, the test mode further comprises a blending mode arranged before the test execution mode; in the blending mode, the control device controls the power module to run in a reciprocating mode, and after the blending time is preset, the testing mode is entered.
Preferably, under the test mode of carrying out, power module drive reagent dish rotates to make each reagent position on the reagent dish rotate in proper order and advance a kind of operation to advance a kind position wait in the operation of advancing, power module reciprocating motion is in order to drive reagent dish reciprocating rotation.
Preferably, the reagent pot further comprises a cold dissipation module, a refrigeration module and a heat dissipation air duct, wherein the cold dissipation module is arranged inside the reagent pot, and the heat dissipation air duct is arranged outside the reagent pot; the cold end of the refrigeration module is connected to the cold dissipation module, and the hot end of the refrigeration module extends into the heat dissipation air duct; and a water outlet is arranged on the reagent pot, and an outlet of the water outlet is communicated with the heat dissipation air duct.
The reagent management device provided by the invention comprises: the reagent pot is internally provided with a reagent plate which is driven by the power module to rotate; and the control device is in communication connection with the power module and comprises a trigger module. The use mode of the reagent management device comprises a test mode, a countdown mode and a reagent replacement mode, wherein the test mode comprises a test execution mode, the use mode is switched to the countdown mode when the trigger module is triggered in the test execution mode, and the use mode is automatically switched to the reagent replacement mode after the countdown mode keeps the preset countdown duration. The control device controls the power module to automatically run according to a set program in a test proceeding mode and a countdown mode, and the power module enters a manual control mode in a reagent replacing mode.
Based on the setting of count-down mode for the device possesses the reservation and trades reagent function, can provide the cushion time for the equipment that uses with reagent pot cooperation, and the adaptation nature with other equipment when reagent pot operation obtains improving, and reducible machine unnecessary loss is favorable to practicing thrift reagent, avoids extravagant.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
FIG. 1 is a cross-sectional view of a reagent disk of a reagent management device of the present invention at a first position when the reagent disk is rotated to a first angle;
FIG. 2 is a cross-sectional view of a reagent disk of the reagent management device of the present invention at a second position when the reagent disk is rotated to a first angle;
FIG. 3 is a top view of the internal structure of a reagent pan of the reagent management device of the present invention;
FIG. 4 is a top view of a reagent management device provided in the present invention;
FIG. 5 is a view showing the construction of a reagent cartridge in the reagent management apparatus according to the present invention;
FIG. 6 is a structural diagram of a trigger module in the reagent management apparatus according to the present invention;
FIG. 7 is a cross-sectional view of a reagent disk of a reagent management device of the present invention rotated to a second angle;
FIG. 8 is an enlarged view of a portion of FIG. 7;
FIG. 9 is a structural diagram of a heat dissipation air duct in the reagent management apparatus of the present invention;
FIG. 10 is a first sectional view of a refrigeration module of the reagent management device;
FIG. 11 is a second sectional view of a refrigeration module of the reagent management device;
FIG. 12 is a cross-sectional view of a power module of the reagent management device of the present invention;
FIG. 13 is a structural view of an outer tooth rotary bearing in the reagent management apparatus according to the present invention.
Reference numerals:
the kit comprises a kit 1, a cooling module 2, a fixed gear ring 3, a reagent tray 4, a power module 5, a tray cover 6, heat-insulating cotton 7, a fixed column 8, a mounting substrate 9, a refrigeration module 10, a heat dissipation air duct 11, a pot bottom 12, a fan 13, a radiator 14, a cold guide plate 15, a refrigeration sheet 16, a heat pipe 17, a heat insulating material 18, a bottle 19 to be mixed, a radio frequency tag 20, a radio frequency antenna plate 21, a movable tray cover 22, a reserved reagent changing button 23, a leakage detection sensor 24, an external tooth slewing bearing 25, a driving motor 26, a synchronous belt 27, a rotating shaft 28, a driving gear 29, a mixing gear ring 30 and a reagent position 31.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The core of the present invention is to provide a reagent management device which is improved in suitability for other devices during operation.
In an embodiment of the reagent management device provided by the present invention, please refer to fig. 1 to 13, which includes a reagent pot, a control device and a power module 5.
A reagent tray 4 is arranged in the reagent pot, specifically, as shown in fig. 1, 7 and 8, a pot bottom 12 of the reagent pot is fixed above a mounting substrate 9, a fixing column 8 is fixedly arranged on the pot bottom 12, and an external tooth slewing bearing 25 is connected on the fixing column 8 in a sleeved mode. The inner ring of the external tooth slewing bearing 25 is fixed on the fixing column 8, and the reagent disk 4 is fixedly arranged above the outer ring, so that the reagent disk 4 can rotate in the reagent pot. The externally toothed slew bearing 25 may be a rolling bearing or a sliding bearing. Wherein, set up reagent position 31 on the reagent dish 4 in order to install reagent box 1, preferably, set up two at least reagent positions 31 on the reagent dish 4 along circumference evenly with its rotation center as the center.
The reagent disk 4 is driven by the power module 5 to rotate. Referring to fig. 12, the power module 5 includes a driving motor 26 mounted on the mounting substrate 9 and a rotating shaft 28 connected to an output shaft of the driving motor 26 through a motor transmission assembly. The rotating shaft 28 is connected to the outer ring of the external-tooth rotating bearing 25 through a rotating shaft transmission assembly, preferably, the motor transmission assembly and the rotating shaft transmission assembly are gear transmission assemblies, but of course, in other embodiments, at least one of the motor transmission assembly and the rotating shaft transmission assembly may be replaced by a synchronous belt transmission assembly.
The power module 5 is connected with the control device in a communication way, and the control device comprises a trigger module. Specifically, the trigger module is a physical or virtual button set on the instrument or software, for example, the trigger module may be a virtual button on the control device, and is triggered when the mouse is double-clicked, or the trigger module is a reserved reagent changing button 23 set on the control device, and the reserved reagent changing button 23 is triggered after a preset trigger time (for example, 3 seconds) is pressed for a long time, and in addition, the reserved reagent changing button 23 may specifically perform a blind operation.
The use mode of the reagent management device comprises a test mode, a countdown mode and a reagent replacement mode, wherein the test mode comprises a test execution mode, the use mode is switched to the countdown mode when the trigger module is triggered in the test execution mode so as to reserve reagent replacement operation, and the use mode is automatically switched to the reagent replacement mode after the countdown mode keeps the preset countdown duration.
The predetermined countdown period may be related to the test item and the test method, for example, 3 minutes, 16 minutes, or other periods. In the countdown mode, the equipment used in cooperation with the reagent pot can have a buffer time to complete the current operation and then stop the operation, for example, the sample injection assembly stops the sample injection operation after completing the sample injection operation of the current batch and does not perform the sample injection operation of the next batch.
Under the test execution mode and the countdown mode, the control device controls the power module 5 to automatically run according to a set program, and the set program comprises control of starting and stopping time, running direction, speed and the like of the power module 5. In the reagent replacement mode, the power module 5 does not operate automatically, but enters a manual control mode to manually control the rotation of the reagent disk 4 according to the reagent taking schedule.
In this embodiment, based on the setting of reservation reagent changing function, can provide buffer time for the equipment that uses with the cooperation of reagent pot, reducible machine unnecessary loss is favorable to practicing thrift reagent, avoids extravagant.
Further, in the countdown mode, when the trigger module is triggered, the usage mode is switched back to the test execution mode. That is to say, within a period of time that the preset countdown duration is not reached after the trigger module enters the countdown mode, if the trigger module is triggered, the countdown mode is cancelled, the test execution mode is returned for testing, and the condition that the trigger module is triggered by mistake to influence the normal execution of subsequent operation can be avoided.
Correspondingly, the control device can control the equipment matched with the reagent pot for use, optionally, in the countdown mode, the sample injection assembly stops sample injection after completing the current sample injection operation, in the test execution mode, the sample injection assembly continuously performs sample injection operation, the sample injection operation comprises a reagent adding process and other operations of the reagent aiming at the reagent kit 1, and the reagent kit 1 stops in the process of waiting for reagent detection at the sample injection position. Wherein, advance the appearance operation and carry out at the appearance position, one advances the appearance position and is a position on the reagent pot, and in this position, reagent pot top is run through and is set up into the sample hole for the reagent needle passes through, when a kit 1 is in one advances the appearance position, corresponds an appearance operation process, and when next kit 1 moved this appearance position, gets into next appearance operation process. In addition, the number of the sample positions on the reagent pot can be one or at least two according to actual needs. In addition, the sample injection operation of a batch may include one or several sample injection operations in succession, for example, four reagent kits 1 complete the sample injection operation of a batch after completing the corresponding sample injection operation at one or at least two sample injection sites in sequence.
The mode switching signal is provided by a single module, namely a trigger module, so as to realize the mode switching of the equipment, and the arrangement of a control module in the equipment can be reduced.
Furthermore, a movable disk cover 22 which can be opened and closed and a disk cover monitoring device for monitoring the opening and closing state of the movable disk cover 22 are arranged on the reagent pot. Specifically, as shown in fig. 4, the top of the reagent pan is provided with two parts, namely a tray cover 6 and a movable tray cover 22, which are matched to cover the top opening of the reagent pan. When the movable tray cover 22 is opened, an access opening is formed, and the worker replaces the reagent cartridge 1 through the access opening.
Preferably, a part of the reagent sites 31 is aligned directly below the pick-and-place port, so that the reagent sites 31 on the reagent disk 4 are moved below the pick-and-place port in batches for picking, placing and replacing the reagent cartridges 1. For example, on the reagent disk 4, 25 reagent positions 31 are uniformly arranged along the circumferential direction with the rotation center thereof as the center, 5 reagent positions 31 are arranged right below the taking and placing port, that is, corresponding to a central angle of 72 degrees, and the reagent cartridges 1 on the 5 reagent positions 31 can be taken out at one time, and then the power module 5 is controlled to drive the reagent disk 4 to rotate 72 degrees, so that the other 5 reagent positions 31 rotate to the position below the taking and placing port to replace the reagent cartridges 1, and thus the reagent cartridges 1 of the 25 reagent positions 31 can be completely replaced by 5 times.
In the reagent change mode and when the trigger module is triggered: if the disc cover monitoring device monitors that the movable disc cover 22 is in a covering state, the control device switches the use mode to the test mode; if the tray cover monitoring device monitors that the movable tray cover 22 is in an open state, the control device controls the power module 5 to drive the reagent tray 4 to rotate by a preset replacement angle.
In this embodiment, in the reagent replacement mode, after the trigger module is triggered according to a different state of the movable cover plate, the device may perform different operations, so as to further increase the functions of the trigger module.
Further, in order to distinguish the use mode, the control device is connected with an indicator light, and the indicator light can be specifically arranged on the trigger module. Specifically, in the countdown mode, the indicator lights blink, in the reagent replacement mode, the indicator lights go out, and in the test execution mode, the indicator lights are always on.
Furthermore, an information reading and writing device is arranged on the reagent pot. The reagent kit is provided with reagent information, and the reagent information specifically comprises reagent types, reagent number of people and the like. Preferably, as shown in fig. 3 and fig. 5, a radio frequency tag 20 serving as a carrier of reagent information is disposed on the reagent kit 1, and specifically, a connection may be attached, and the information reading and writing device is a radio frequency antenna board 21. The reading and writing are carried out by adopting a radio frequency code scanning mode, the speed is high, the information quantity is large, and the accuracy is high.
Accordingly, the test mode further includes a scan mode performed before the test performing mode. In the tray scanning mode, the power module 5 drives the reagent tray 4 to rotate, the information reading and writing device sequentially reads the reagent information on the reagent kit 1 moving to the reading range of the information reading and writing device, and the information reading and writing device can write the read information into the control device.
The scan mode is performed before the test run mode. The control device can specifically judge whether the subsequent operation can be performed according to the reagent information written by the information reading and writing device. In addition, if the subsequent operation cannot be carried out, the reagent replacing mode can be directly entered or alarm information can be sent out.
Further, as shown in fig. 3, a leak detection sensor 24 is also provided on the reagent pot, and the leak detection sensor 24 is used for detecting each reagent level 31 to determine whether the reagent kit 1 is mounted thereon. The information read-write device starts and reads the corresponding reagent information on the reagent kit 1 when the reagent site 31 with the reagent kit 1 is moved to the reading range according to the detection result of the leak detection sensor 24. Specifically, after the information reading and writing device is started, information can be written while information is read, or information can be written after information is read for a period of time.
In this embodiment, under the cooperation of detection by the leak detection sensor 24 and rotation of the reagent disk 4, the radio frequency antenna plate 21 reads and writes information of the reagent kit 1 by scanning the radio frequency tag 20 on the reagent kit 1, wherein if the reagent kit 1 is not located on the reagent site 31 in the reading range, the information reading and writing device is not started, so that the reagent information reading and writing efficiency can be effectively improved, and the time of the disk scanning mode is saved.
Further, as shown in fig. 3, at least two reagent sites 31 are uniformly arranged on the reagent disk 4 in the circumferential direction. The leak detection sensor 24 and the information reading and writing device are sequentially fixed on the inner side wall of the reagent pot along the circumferential direction, and the reagent position 31 in the detection range of the leak detection sensor 24 and the reagent position 31 in the reading range of the information reading and writing device are adjacent along the circumferential direction.
In the tray scanning mode, taking a first reagent level in the reagent levels 31 as an example, the leak detection sensor 24 detects whether there is a reagent kit 1 at the first reagent level that is directly opposite to the first reagent level, where the next reagent level that moves into the reading range of the rf antenna board 21 is the first reagent level: if not, the radio frequency antenna plate 21 skips the first reagent position when scanning and reading information; if the reagent box 1 information (reagent type, reagent number, etc.) in the reagent pot is read by the radio frequency antenna board 21 in a radio frequency scanning mode, so as to check whether the current reagent meets the current test requirement, for example, the reagent type or the reagent number is insufficient, and the system prompts to replace the reagent or supplement the reagent. When the test execution mode is finished, the information of the kit 1 is written in by a radio frequency scanning mode, and the latest information of the reagent in the reagent pot is written in, so that whether the reagent in the reagent pot meets the requirement of the next test can be checked before the next test execution mode is entered.
Further, a mixing transmission mechanism is arranged between the bottle 19 to be mixed and the reagent pot in the reagent kit 1, so that when the reagent disk 4 rotates, the mixing transmission mechanism drives the bottle 19 to be mixed to rotate on the reagent disk 4. Specifically, as shown in fig. 5 and 7, the bottle 19 to be mixed is a magnetic bead bottle, the reagent pot is fixedly connected with the fixed gear ring 3, the magnetic bead bottle is fixedly provided with a mixing gear ring 30 engaged with the fixed gear ring 3, and the fixed gear ring 3, the reagent disk 4 and the external tooth rotary bearing 25 are coaxially arranged. When the reagent disk 4 rotates, the fixed gear ring 3 does not rotate, and the magnetic bead bottle is driven to rotate by meshing transmission with the blending gear ring 30.
In this embodiment, when the reagent box 1 revolves around the rotation center of the reagent disk 4 as the center, the magnetic bead bottle rotates under the drive of the gear transmission mechanism, the rotation does not need to set up a driving device additionally, and only one power module 5 is suitable for, so that the requirements of the rotation of the reagent disk 4 and the uniform mixing of the magnetic beads can be met, and the cost is saved.
Of course, in other embodiments, the gear transmission mechanism may be replaced by a friction wheel transmission mechanism, specifically, a fixing ring coaxial with the rotation center of the reagent kit 1 is fixedly disposed in the reagent pot, and a blending friction wheel is disposed on the magnetic bead bottle and frictionally engages with the fixing ring to drive the blending friction wheel to rotate through friction.
Further, the test mode further includes a blending mode provided before the test execution mode. In the blending mode, the control device controls the power module 5 to reciprocate, and after the blending time is preset, the testing mode is started. The magnetic beads are uniformly mixed, the test waiting time in the test execution mode can be saved, and specifically, the power module 5 drives the reagent disk 4 to continuously rotate clockwise for N degrees and rotate anticlockwise for N degrees, and then the operation is repeated for the set times. Specifically, the kneading mode is performed between the sweeping tray mode and the test execution mode.
Further, under the test mode of carrying out, power module 5 drive reagent dish 4 rotates to make each reagent position 31 on reagent dish 4 rotate in proper order and advance a kind position and advance a kind operation, in the waiting process in advancing a kind operation, the reagent needle is operated outside the reagent pot, can not interfere the action of kit or reagent dish 4, and in this waiting process, power module 5 reciprocating motion is with the reciprocal rotation of drive reagent dish 4. Specifically, in the waiting process of the sample injection operation, the reagent disk 4 rotates clockwise by N ° and counterclockwise by N ° to perform the mixing operation, and then the reagent cassette 1 at the current reagent position 31 moves to the sample injection position to perform the next sample injection operation.
That is to say, also carry out the magnetic bead mixing in test mode, prevent that the magnetic bead deposits and causes the influence to the test result in the test process. In addition, the reagent is uniformly mixed before the test is carried out in a mode and in the reagent adding process, the reagent mixing degree is high, the mixing speed is high, the mixing degree can be fully ensured, and the accuracy of a sample test result is ensured.
Further, the reagent management device further comprises a cold dissipation module 2, a refrigeration module 10 and a heat dissipation air duct 11, wherein the cold dissipation module 2 is arranged inside the reagent pot, and the heat dissipation air duct 11 is arranged outside the reagent pot. The cold end of the refrigeration module 10 is connected to the cooling module 2, and the hot end extends into the cooling air duct 11. The reagent pot is provided with a water outlet, and the outlet of the water outlet is communicated with the heat dissipation air duct 11.
One or at least two of the refrigeration modules 10 may be provided. The refrigeration module 10 can perform refrigeration by air cooling alone, water cooling alone, or a combination of water cooling and air cooling. Specifically, as shown in fig. 10 and 11, the refrigeration module 10 includes a heat sink 14, a cold conducting plate 15, a refrigeration sheet 16, a heat pipe 17, and a heat insulating material 18. The cold end of the refrigeration module 10 is fixed on the bottom 12 of the reagent pot, the cold air at the cold end of the refrigeration piece 16 is transmitted to the bottom 12 of the reagent pot through the cold guide plate 15, the cold air on the bottom 12 circulates in the reagent pot under the action of the cold dissipation module 2, the air cooling and cooling are realized, and the refrigeration is uniform. The hot end of the refrigeration module 10 is arranged in the air duct, and the high temperature generated by the hot end of the refrigeration sheet 16 is transferred to the radiator 14 and the heat pipe 17.
As shown in fig. 7 and 9, the heat dissipation air duct 11 includes two openings, and the rest is designed in a closed manner, wherein one opening is provided with a fan 13 as an air inlet, and the other opening is provided with an air outlet. The fan 13 drives the air in the heat dissipation air duct 11 to flow, and continuously cools the heat sink 14 to ensure continuous cooling.
Wherein, the comdenstion water that the outlet on the reagent pot discharged gets into in the heat dissipation wind channel 11 after, is accepted by the wind channel pocket in the heat dissipation wind channel 11, and the comdenstion water in the wind channel pocket evaporates under the effect of the high temperature gas in the heat dissipation wind channel 11, and the ambient temperature in the wind channel that absorbs heat messenger in the water evaporation process reduces, and the ambient temperature in the heat dissipation wind channel 11 reduces and helps radiator 14 heat dissipation, helps improving the refrigeration efficiency of refrigeration piece 16.
The reagent management device that this embodiment provided, it possesses the magnetic bead mixing, reagent refrigeration, reagent information reading and writing, reagent reservation change function, and specific theory of operation is as follows:
entering a tray scanning mode, rotating the reagent tray 4 by 360 degrees, and reading the reagent information on the reagent kit 1;
entering a mixing mode, rotating the reagent disk 4 in a reciprocating mode, and rotating the magnetic bead bottle to mix uniformly;
entering a test execution mode, wherein the reagent disk 4 drives each reagent position 31 to move to a sample injection position in sequence, in the mode, if the trigger module is triggered, the indicator light is changed from a normally-on state to a flashing state, after the sample injection of the current batch is finished, the sample injection is stopped, the use mode is switched to a countdown mode, after entering the countdown mode and before the waiting mode, if the trigger module is triggered, the use mode is switched back to the test execution mode, the reserved reagent changing operation which is in progress in the countdown mode is cancelled, at the moment, the indicator light is changed from the flashing state to the back-on state, and the sample injection assembly continues to perform the sample injection; after the reagent box 1 is successfully put into the waiting mode after the countdown mode, the indication is changed from blinking to being off, and a user can open the movable disk cover 22 to replace the reagent box 1;
when the reagent kit enters the waiting mode, the movable disk cover 22 is opened, when the trigger component is triggered, the indicator light is turned on and the reagent disk 4 rotates for an angle while being triggered to operate, for example, the trigger component is a button, the indicator light is turned on along with pressing, the reagent disk 4 follows along with pressing, the reagent disk 4 rotates for 72 degrees after pressing, the rotating disk rotates for 5 times, and a user can finish the replacement of the whole reagent kit 1; after covering movable cover 22, when the trigger subassembly was triggered, the pilot lamp became the normal bright state by the off-state, and equipment will be swept processes such as dish, mixing, application of sample again.
It will be understood that when an element is referred to as being "secured" to another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings for convenience in describing the invention and for simplicity in description, and do not indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be construed as limiting the invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The reagent management apparatus provided by the present invention is described in detail above. The principles and embodiments of the present invention are explained herein using specific examples, which are presented only to assist in understanding the method and its core concepts. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
Claims (10)
1. A reagent management device, comprising:
the reagent pot is internally provided with a reagent plate (4), and the reagent plate (4) is driven by a power module (5) to rotate;
the control device is connected with the power module (5) in a communication manner and comprises a trigger module;
the using mode of the reagent management device comprises a testing mode, a countdown mode and a reagent replacing mode, wherein the testing mode comprises a testing proceeding mode, the using mode is switched to the countdown mode when the triggering module is triggered in the testing proceeding mode, and the using mode is automatically switched to the reagent replacing mode after the countdown mode keeps a preset countdown duration;
under the test execution mode and the countdown mode, the control device controls the power module (5) to automatically run according to a set program, and under the reagent replacement mode, the power module (5) enters a manual control mode.
2. The reagent management device according to claim 1, wherein the use mode is switched back to the test execution mode when the trigger module is triggered in the countdown mode.
3. The reagent management device of claim 2, wherein the reagent pot is provided with a movable disk cover (22) which can be opened and closed and a disk cover monitoring device for monitoring the opening and closing state of the movable disk cover (22);
in the reagent replacement mode, when the trigger module is triggered:
if the disc cover monitoring device monitors that the movable disc cover (22) is in a closed state, the control device switches the use mode to the test mode;
if the tray cover monitoring device monitors that the movable tray cover (22) is in an open state, the control device controls the power module (5) to drive the reagent tray (4) to rotate by a preset replacement angle.
4. The reagent management device of claim 1, wherein the reagent tray (4) is provided with a reagent position (31) for installing a reagent box (1), and the reagent pan is provided with an information reading and writing device;
the test mode further comprises a scan mode performed before the test proceeding mode;
in the tray scanning mode, the power module (5) drives the reagent tray (4) to rotate, the information reading and writing device sequentially reads the reagent information on the reagent kit (1) moving to the reading range of the information reading and writing device, and the information reading and writing device can write the read information into the control device.
5. The reagent management device of claim 4, wherein the reagent pan is further provided with a leak detection sensor (24), and the leak detection sensor (24) is used for detecting each reagent position (31) to determine whether a reagent box (1) is mounted on the reagent pan;
and the information reading and writing device is started when a reagent position (31) provided with the reagent kit (1) moves to the reading range according to the detection result of the leakage detection sensor (24), and reads and/or writes corresponding reagent information on the reagent kit (1).
6. The reagent management device according to claim 4, wherein at least two of the reagent sites (31) are arranged evenly in the circumferential direction on the reagent tray (4);
the leak detection sensor (24) and the information reading and writing device are sequentially fixed on the inner side wall of the reagent pot along the circumferential direction, and the reagent bit (31) in the detection range of the leak detection sensor (24) and the reagent bit (31) in the reading range of the information reading and writing device are adjacent along the circumferential direction.
7. The reagent management device of claim 4, wherein a mixing transmission mechanism is arranged between the to-be-mixed bottle (19) in the reagent kit (1) and the reagent pot, so that when the reagent disk (4) rotates, the mixing transmission mechanism drives the to-be-mixed bottle (19) to rotate on the reagent disk (4).
8. The reagent management device according to claim 7, wherein the test mode further includes a kneading mode provided before the test execution mode; in the blending mode, the control device controls the power module (5) to reciprocate, and after the blending time is preset, the test execution mode is entered.
9. The reagent management device according to any one of claims 1 to 8, wherein in the test execution mode, the power module (5) drives the reagent disk (4) to rotate, so that each reagent site (31) on the reagent disk (4) sequentially rotates to a sample injection site for sample injection operation, and during the waiting process in the sample injection operation, the power module (5) reciprocates to drive the reagent disk (4) to rotate reciprocally.
10. The reagent management device according to any one of claims 1 to 8, further comprising a cooling module (2), a refrigeration module (10) and a cooling air duct (11), wherein the cooling module (2) is arranged inside the reagent pot, and the cooling air duct (11) is arranged outside the reagent pot; the cold end of the refrigeration module (10) is connected to the cold dissipation module (2), and the hot end of the refrigeration module extends into the heat dissipation air duct (11); a water outlet is arranged on the reagent pot, and the outlet of the water outlet is communicated with the heat dissipation air duct (11).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011583247.2A CN112763733A (en) | 2020-12-28 | 2020-12-28 | Reagent management device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011583247.2A CN112763733A (en) | 2020-12-28 | 2020-12-28 | Reagent management device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112763733A true CN112763733A (en) | 2021-05-07 |
Family
ID=75696518
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011583247.2A Pending CN112763733A (en) | 2020-12-28 | 2020-12-28 | Reagent management device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112763733A (en) |
Citations (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10232234A (en) * | 1997-02-19 | 1998-09-02 | Hitachi Ltd | Automatic analyzer |
| US6090630A (en) * | 1996-11-15 | 2000-07-18 | Hitachi, Ltd. | Method and apparatus for automatically analyzing reaction solutions of samples |
| JP2007113990A (en) * | 2005-10-19 | 2007-05-10 | Nippon Instrument Kk | Instrument for measuring hydride generation mercury with automatic pretreatment mechanism |
| CN201867865U (en) * | 2010-11-26 | 2011-06-15 | 深圳市爱康电子有限公司 | Device for computerized management of reagents |
| CN103034469A (en) * | 2013-01-17 | 2013-04-10 | 力合科技（湖南）股份有限公司 | Count-down time display method and device |
| CN103675302A (en) * | 2012-09-21 | 2014-03-26 | 深圳迈瑞生物医疗电子股份有限公司 | Reagent loading method and system, and biochemical analyzer |
| CN104329858A (en) * | 2014-03-28 | 2015-02-04 | 海尔集团公司 | Mixed refrigeration refrigerator with cold storage and refrigeration functions |
| CN105283767A (en) * | 2013-07-09 | 2016-01-27 | 株式会社日立高新技术 | Automatic analysis device |
| CN106370877A (en) * | 2016-12-13 | 2017-02-01 | 安图实验仪器(郑州)有限公司 | Online reagent replacement control system for full-automatic chemiluminescence immunity analyzer |
| CN206097144U (en) * | 2016-08-15 | 2017-04-12 | 安图诺生（北京）生物科技有限公司 | External diagnostic reagent manages device |
| CN108072075A (en) * | 2017-07-28 | 2018-05-25 | 宁波方太厨具有限公司 | A kind of refrigeration range hood |
| CN108159973A (en) * | 2018-01-09 | 2018-06-15 | 苏州长光华医生物医学工程有限公司 | A kind of reagent chamber structure |
| CN108226549A (en) * | 2018-01-15 | 2018-06-29 | 重庆博奥新景医学科技有限公司 | A kind of sequential control method and system for chemical illumination immunity analysis instrument |
| CN109269206A (en) * | 2018-09-27 | 2019-01-25 | 贵州民族大学 | A kind of automation control super low-temperature refrigerator radiator |
| CN209337196U (en) * | 2018-11-13 | 2019-09-03 | 苏州迈瑞科技有限公司 | A kind of reagent container, reagent apparatus for placing and medical diagnostic equipment |
| CN111310875A (en) * | 2020-02-28 | 2020-06-19 | 蓝怡科技集团股份有限公司 | Reagent detection system, method, computer device and readable storage medium |
| CN111381061A (en) * | 2018-12-27 | 2020-07-07 | 深圳迈瑞生物医疗电子股份有限公司 | Reagent management method, reagent supply device and blood cell analyzer |
| CN211167977U (en) * | 2019-12-24 | 2020-08-04 | 潍坊麦克利生物科技有限公司 | Novel biological detection kit |
| CN111781392A (en) * | 2020-08-13 | 2020-10-16 | 安图实验仪器(郑州)有限公司 | Medical analyzer and kit thereof |
-
2020
- 2020-12-28 CN CN202011583247.2A patent/CN112763733A/en active Pending
Patent Citations (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6090630A (en) * | 1996-11-15 | 2000-07-18 | Hitachi, Ltd. | Method and apparatus for automatically analyzing reaction solutions of samples |
| JPH10232234A (en) * | 1997-02-19 | 1998-09-02 | Hitachi Ltd | Automatic analyzer |
| JP2007113990A (en) * | 2005-10-19 | 2007-05-10 | Nippon Instrument Kk | Instrument for measuring hydride generation mercury with automatic pretreatment mechanism |
| CN201867865U (en) * | 2010-11-26 | 2011-06-15 | 深圳市爱康电子有限公司 | Device for computerized management of reagents |
| CN103675302A (en) * | 2012-09-21 | 2014-03-26 | 深圳迈瑞生物医疗电子股份有限公司 | Reagent loading method and system, and biochemical analyzer |
| CN103034469A (en) * | 2013-01-17 | 2013-04-10 | 力合科技（湖南）股份有限公司 | Count-down time display method and device |
| CN105283767A (en) * | 2013-07-09 | 2016-01-27 | 株式会社日立高新技术 | Automatic analysis device |
| CN104329858A (en) * | 2014-03-28 | 2015-02-04 | 海尔集团公司 | Mixed refrigeration refrigerator with cold storage and refrigeration functions |
| CN206097144U (en) * | 2016-08-15 | 2017-04-12 | 安图诺生（北京）生物科技有限公司 | External diagnostic reagent manages device |
| CN106370877A (en) * | 2016-12-13 | 2017-02-01 | 安图实验仪器(郑州)有限公司 | Online reagent replacement control system for full-automatic chemiluminescence immunity analyzer |
| CN108072075A (en) * | 2017-07-28 | 2018-05-25 | 宁波方太厨具有限公司 | A kind of refrigeration range hood |
| CN108159973A (en) * | 2018-01-09 | 2018-06-15 | 苏州长光华医生物医学工程有限公司 | A kind of reagent chamber structure |
| CN108226549A (en) * | 2018-01-15 | 2018-06-29 | 重庆博奥新景医学科技有限公司 | A kind of sequential control method and system for chemical illumination immunity analysis instrument |
| CN109269206A (en) * | 2018-09-27 | 2019-01-25 | 贵州民族大学 | A kind of automation control super low-temperature refrigerator radiator |
| CN209337196U (en) * | 2018-11-13 | 2019-09-03 | 苏州迈瑞科技有限公司 | A kind of reagent container, reagent apparatus for placing and medical diagnostic equipment |
| CN111381061A (en) * | 2018-12-27 | 2020-07-07 | 深圳迈瑞生物医疗电子股份有限公司 | Reagent management method, reagent supply device and blood cell analyzer |
| CN211167977U (en) * | 2019-12-24 | 2020-08-04 | 潍坊麦克利生物科技有限公司 | Novel biological detection kit |
| CN111310875A (en) * | 2020-02-28 | 2020-06-19 | 蓝怡科技集团股份有限公司 | Reagent detection system, method, computer device and readable storage medium |
| CN111781392A (en) * | 2020-08-13 | 2020-10-16 | 安图实验仪器(郑州)有限公司 | Medical analyzer and kit thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102221626B (en) | Automatic biochemistry analyzer and working method thereof | |
| CN103592450B (en) | Full-automatic chemiluminescence immunoassay analyzer | |
| CN106918715B (en) | A kind of chemiluminescence diagnostic device and its system | |
| US10908175B2 (en) | Sample analyzer and liquid aspirating method | |
| EP3229028A1 (en) | Circular type cartridge enabling centrifugation and modular automatic analyzer using the same | |
| EP3742170B1 (en) | Full-automatic western blotting analyzer | |
| CN109142766A (en) | Chemiluminescence detector | |
| US20090104704A1 (en) | Apparatus and method for anaylizing samples | |
| CN106018784A (en) | Small electrochemical luminescence immunoassay analyzer and analysis method thereof | |
| CN109100529A (en) | Reagent bottle autoloading structure | |
| CN208140726U (en) | A kind of chemical illumination immunity analysis instrument | |
| CN111298857A (en) | Novel reagent refrigeration mechanism | |
| CN111094994A (en) | Automatic analyzer | |
| CN112763733A (en) | Reagent management device | |
| CN109612691A (en) | A kind of rotary display panel testing | |
| CN109580595B (en) | Chemiluminescent detector, incubation device and reaction disk mechanism | |
| JP4538365B2 (en) | Reagent cooler and automatic analyzer equipped with the same | |
| CN209432406U (en) | A kind of rotary display panel testing | |
| CN109580596A (en) | Chemiluminescence detector incubates device and its Incubation methods | |
| CN212309630U (en) | Novel reagent refrigeration mechanism | |
| JP2011013127A (en) | Automatic analyzer and control method of the same | |
| CN107121558A (en) | It is a kind of to extend the biochemical analyser of the corkage reagent term of validity | |
| CN114755438B (en) | Full-automatic biochemical analyzer | |
| WO2016203919A1 (en) | Automatic analyzing device | |
| CN204177727U (en) | POCT biochemical analyzer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |