CN110045110A - For dry type fluorescence/colloid gold reagent card detection temperature control compartment and temperature control method - Google Patents
For dry type fluorescence/colloid gold reagent card detection temperature control compartment and temperature control method Download PDFInfo
- Publication number
- CN110045110A CN110045110A CN201910476899.7A CN201910476899A CN110045110A CN 110045110 A CN110045110 A CN 110045110A CN 201910476899 A CN201910476899 A CN 201910476899A CN 110045110 A CN110045110 A CN 110045110A
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- temperature control
- control compartment
- peltier
- dry type
- colloid gold
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- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 39
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 239000010931 gold Substances 0.000 title claims abstract description 31
- 229910052737 gold Inorganic materials 0.000 title claims abstract description 31
- 239000000084 colloidal system Substances 0.000 title claims abstract description 30
- 238000001514 detection method Methods 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims description 11
- 238000001816 cooling Methods 0.000 claims abstract description 52
- 239000004065 semiconductor Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 7
- 239000007769 metal material Substances 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 abstract description 16
- 238000006243 chemical reaction Methods 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 238000005057 refrigeration Methods 0.000 description 6
- 238000004587 chromatography analysis Methods 0.000 description 4
- 235000009967 Erodium cicutarium Nutrition 0.000 description 2
- 230000005679 Peltier effect Effects 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 230000017525 heat dissipation Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002558 medical inspection Methods 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000014612 sandwich biscuits Nutrition 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D23/00—Control of temperature
- G05D23/19—Control of temperature characterised by the use of electric means
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Automation & Control Theory (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
It is disclosed by the invention to be used for dry type fluorescence/colloid gold reagent card detection temperature control compartment, including temperature control compartment warehouse, M temperature control component, M >=1 are installed on temperature control compartment warehouse side wall；Wherein, temperature control component includes Peltier, is provided with heat insulating mattress between Peltier surrounding and temperature control compartment warehouse side wall.Peltier is locked among two radiating fins by the present invention by screw, and Peltier surrounding is wrapped up by heat insulating mattress, to prevent cold and hot surface temperature crosstalk.The hot and cold fast spread for having radiator fan to generate Peltier on two cooling fins accelerates the heat exchange action with the air in respective environment.Peltier heating or chill surface are converted by changing the current direction at Peltier the two poles of the earth, first cooling fin and the first fan are located inside temperature control compartment, by Peltier generate it is hot or cold being dispersed in temperature control compartment by air in storehouse, be maintained at temperature control compartment within the scope of specific temperature.
Description
Technical field
The present invention relates to quick medical inspection fields, in particular to for dry type fluorescence/colloid gold reagent card detection temperature
Control storehouse and temperature control method.
Background technique
Dry type fluorescence/dot immune gold filtration assay is a kind of quick medical inspection technology, the corresponding device of this technical solution
Including dry type fluorescence/colloid gold reagent card, optical measurement module and reagent card moving assembly, reagent card is moved by moving assembly
It moves to optical measurement module and detects position accordingly, be scanned detection.
Before carrying out Scanning Detction to dry type fluorescence/colloid gold reagent card, it is necessary first to by dry type fluorescence/colloid gold reagent
Card is sent from card feeding device to temperature control compartment, so that dry type fluorescence/colloid gold reagent is stuck in the relatively stable and controllable ring of temperature
It is reacted within the border.
The detection of dry type fluorescence/colloidal gold needs relatively stable when determinand and detection reagent react and meets reaction and want
The temperature environment asked, to ensure the repeatability and accuracy of testing result.However existing dry type fluorescence/colloidal gold detecting instrument
There is no corresponding temperature control scheme to the control of temperature, be perhaps completely dependent on room temperature environment or auxiliary heating function can only be provided, when
Environment temperature requires not freezing when temperature range to meet the requirement of reaction temperature beyond reaction.
Summary of the invention
The purpose of the present invention is to overcome the shortcomings of the existing technology and deficiency, provides for dry type fluorescence/colloid gold reagent
Block the temperature control compartment of detection.
Another object of the present invention is to provide for dry type fluorescence/colloid gold reagent card detection temperature control method.
The purpose of the present invention is realized by the following technical solution:
For the temperature control compartment of dry type fluorescence/colloid gold reagent card detection, including temperature control compartment warehouse, on temperature control compartment warehouse side wall
M temperature control component, M >=1 are installed；Wherein, temperature control component includes Peltier, between Peltier surrounding and temperature control compartment warehouse side wall
It is provided with heat insulating mattress.
The Peltier is provided with the first cooling fin in the side inside the temperature control compartment warehouse, on the first cooling fin
It is provided with the first fan.
First cooling fin includes more than one bar shaped fin, and the diameter of the first fan is no more than the first cooling fin
Width.Increase the contact area of cooling fin and air by bar shaped fin.The area of first cooling fin and the first fan is relatively
Small, main cause is: 1. temperature control compartment inner spaces are smaller, need the air capacity of heating/refrigerating few；2. the heating efficiency of Peltier
To be much higher than refrigerating efficiency, therefore when heating to small space, not need very strong radiating efficiency.Simultaneously as temperature control is empty
Between it is smaller, extra high cold scattering efficiency is not needed when being freezed yet.3. the reaction power source of reagent card first is that micro liquid
Self start type chromatography power (capillarity) of body can accelerate evaporation (the especially micro liquid of liquid under strong cross-ventilation environment
Body, total amount of liquid in a reagent card are usually no more than 200 μ L), to interrupt chromatography, lead to reaction terminating.Therefore, it is necessary to
The air velocity on strict control reagent card surface, and the lesser fan of usable floor area, can satisfy the requirement of this aspect just.
The Peltier is provided with the second cooling fin in the side outside the temperature control compartment warehouse, on the second cooling fin
It is provided with the second fan.
Second cooling fin is sun flower-shape fin, and the diameter of the second fan is equal to the diameter of sun flower-shape fin.Too
The specific surface area of positive flower-shape fin heatsink is bigger than bar shaped fin, has bigger air contact surfaces, to reinforce radiating
Effect.The area of second cooling fin and the second fan is relatively large, and main cause is: in 1. temperature control compartments when refrigeration, the second heat dissipation
Bit end is fever end, and its heating power is positively correlated (i.e. internal temperature is lower, and outside heat is more) with refrigeration work consumption, therefore needs
More efficient radiating efficiency is wanted, while being flowed using the air of higher speed, the heat on cooling fin is dispelled into rapidly external rings
In border.2. heronsbill shape can allow thermal current to evenly spread in space, without will form local air mistake in space
The situation of heat.
The Peltier is made of semiconductor material or metal material.In general, the peltier effect of metal material
It is fainter, and semiconductor material then wants much better than, thus the thermoelectric cooling device for obtaining practical application is all by semiconductor
Made of material.
The temperature control compartment warehouse also sets up the door that can be opened, be closed, and is used for dry type fluorescence/colloid gold reagent card
Pass in and out temperature control compartment.
Another object of the present invention is realized by the following technical solution:
For dry type fluorescence/colloid gold reagent card detection temperature control method, include the steps that following sequence:
Temperature control compartment required temperature is set according to actual needs, and temperature control compartment warehouse inner air is heated using Peltier
Or refrigeration；It is specific as follows:
If Peltier forward direction is powered, heat to temperature control compartment warehouse inner air: temperature control compartment warehouse inner air needs
Heating, then Peltier forward direction is powered；Temperature control compartment warehouse inner air needs to freeze, then Peltier is reversely powered；
If Peltier forward direction is powered, freeze to temperature control compartment warehouse inner air, similarly.
The temperature control method detected for dry type fluorescence/colloid gold reagent card, further comprising the steps of:
When Peltier is powered, work synchronous with the first cooling fin, the first fan of Peltier abutting inside temperature control compartment warehouse
Make；Meanwhile the second cooling fin, the second fan being close to outside temperature control compartment warehouse with Peltier also work asynchronously.
Compared with the prior art, the invention has the following advantages and beneficial effects:
The present invention uses thermoelectric semiconductor heating/refrigerating device (i.e. Peltier), can pass through change according to setting temperature control temperature
Current direction realizes the cold heat face conversion of semiconductor, realizes heating or the refrigerating function of temperature control compartment.
Semiconductor cold heat face of the invention is equipped with cooling fin and fan, and the heat Quick uniform in cold heat face can be made to spread
To space environment, quick equalized temperature is realized.
Temperature control component of the invention is a kind of sandwich biscuits structure, and Peltier is locked at two radiating fins by screw
Centre, Peltier surrounding are wrapped up by heat insulating mattress, to prevent cold and hot surface temperature crosstalk.There is radiator fan by Paar on two cooling fins
The hot and cold fast spread generated is pasted, the heat exchange action with the air in respective environment is accelerated.By changing Peltier the two poles of the earth
Current direction come convert Peltier heating or chill surface, the first cooling fin and the first fan are located inside temperature control compartment, by Paar
Patch generate it is hot or cold being dispersed in temperature control compartment by air in storehouse, be maintained at temperature control compartment within the scope of specific temperature.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the present invention for dry type fluorescence/colloid gold reagent card detection temperature control compartment.
Fig. 2 is the structural schematic diagram of the present invention for dry type fluorescence/colloid gold reagent card detection temperature control compartment, the figure
It can see the inside of temperature control compartment.
Fig. 3 is the explosive view of temperature control component of the present invention.
Wherein, appended drawing reference meaning is as follows:
1- temperature control compartment warehouse, 2- Peltier, 3- heat insulating mattress, the first cooling fin of 4-, the first fan of 5-, the second cooling fin of 6-,
The second fan of 7-, 8- install screw.
Specific embodiment
Present invention will now be described in further detail with reference to the embodiments and the accompanying drawings, but embodiments of the present invention are unlimited
In this.
Such as Fig. 1,2,3, for dry type fluorescence/colloid gold reagent card detection temperature control compartment, including temperature control compartment warehouse, temperature control compartment
M temperature control component, M=2 are installed on warehouse side wall；Wherein, temperature control component includes Peltier, Peltier surrounding and temperature control compartment storehouse
Heat insulating mattress is provided between body sidewall.
The Peltier is provided with the first cooling fin in the side inside the temperature control compartment warehouse, on the first cooling fin
It is provided with the first fan.
First cooling fin includes more than one bar shaped fin, and the diameter of the first fan is no more than the first cooling fin
Width.Increase the contact area of cooling fin and air by bar shaped fin.The area of first cooling fin and the first fan is relatively
Small, main cause is: 1. temperature control compartment inner spaces are smaller, need the air capacity of heating/refrigerating few；2. the heating efficiency of Peltier
To be much higher than refrigerating efficiency, therefore when heating to small space, not need very strong radiating efficiency.Simultaneously as temperature control is empty
Between it is smaller, extra high cold scattering efficiency is not needed when being freezed yet.3. the reaction power source of reagent card first is that micro liquid
Self start type chromatography power (capillarity) of body can accelerate evaporation (the especially micro liquid of liquid under strong cross-ventilation environment
Body, total amount of liquid in a reagent card are usually no more than 200 μ L), to interrupt chromatography, lead to reaction terminating.Therefore, it is necessary to
The air velocity on strict control reagent card surface, and the lesser fan of usable floor area, can satisfy the requirement of this aspect just.
The Peltier is provided with the second cooling fin in the side outside the temperature control compartment warehouse, on the second cooling fin
It is provided with the second fan.
Second cooling fin is sun flower-shape fin, and the diameter of the second fan is equal to the diameter of sun flower-shape fin.Too
The specific surface area of positive flower-shape fin heatsink is bigger than bar shaped fin, has bigger air contact surfaces, to reinforce radiating
Effect.The area of second cooling fin and the second fan is relatively large, and main cause is: in 1. temperature control compartments when refrigeration, the second heat dissipation
Bit end is fever end, and its heating power is positively correlated (i.e. internal temperature is lower, and outside heat is more) with refrigeration work consumption, therefore needs
More efficient radiating efficiency is wanted, while being flowed using the air of higher speed, the heat on cooling fin is dispelled into rapidly external rings
In border.2. heronsbill shape can allow thermal current to evenly spread in space, without will form local air mistake in space
The situation of heat.
The Peltier is made of semiconductor material or metal material.In general, the peltier effect of metal material
It is fainter, and semiconductor material then wants much better than, thus the thermoelectric cooling device for obtaining practical application is all by semiconductor
Made of material.
The temperature control compartment warehouse also sets up the door that can be opened, be closed, and is used for dry type fluorescence/colloid gold reagent card
Pass in and out temperature control compartment.
First cooling fin can not only use bar shaped fin, and the second cooling fin also can not only use sun flower-shape fin,
In the present embodiment, only by " the first cooling fin includes more than one bar shaped fin ", " the second cooling fin be sun flower-shape fin
Piece " is preferably；As long as actually the first cooling fin, the second cooling fin fin can substantially meet use and want
It asks.
Such as Fig. 3, the temperature control component is a kind of sandwich cake layer structure, and Peltier is locked at two layers by installation screw and is dissipated
Among backing, Peltier surrounding is wrapped up by heat insulating mattress, be fitted on two panels cooling fin heat that fan generates Peltier and
Cooling capacity is scattered, and changes Peltier heating surface and chill surface by changing the current direction at Peltier the two poles of the earth.
For dry type fluorescence/colloid gold reagent card detection temperature control method, include the steps that following sequence:
Temperature control compartment required temperature is set according to actual needs, and temperature control compartment warehouse inner air is heated using Peltier
Or refrigeration；It is specific as follows:
If Peltier forward direction is powered, heat to temperature control compartment warehouse inner air: temperature control compartment warehouse inner air needs
Heating, then Peltier forward direction is powered；Temperature control compartment warehouse inner air needs to freeze, then Peltier is reversely powered；
If Peltier forward direction is powered, freeze to temperature control compartment warehouse inner air, similarly.
The temperature control method detected for dry type fluorescence/colloid gold reagent card, further comprising the steps of:
When Peltier is powered, work synchronous with the first cooling fin, the first fan of Peltier abutting inside temperature control compartment warehouse
Make；Meanwhile the second cooling fin, the second fan being close to outside temperature control compartment warehouse with Peltier also work asynchronously.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (9)
1. for dry type fluorescence/colloid gold reagent card detection temperature control compartment, it is characterised in that: including temperature control compartment warehouse, temperature control compartment
M temperature control component, M >=1 are installed on warehouse side wall；Wherein, temperature control component includes Peltier, Peltier surrounding and temperature control compartment storehouse
Heat insulating mattress is provided between body sidewall.
2. according to claim 1 for dry type fluorescence/colloid gold reagent card detection temperature control compartment, it is characterised in that: described
Peltier is provided with the first cooling fin in the side inside temperature control compartment warehouse, and the first wind is provided on the first cooling fin
Fan.
3. according to claim 2 for dry type fluorescence/colloid gold reagent card detection temperature control compartment, it is characterised in that: described
First cooling fin includes more than one bar shaped fin, and the diameter of the first fan is not more than the width of the first cooling fin.
4. according to claim 1 or claim 2 for dry type fluorescence/colloid gold reagent card detection temperature control compartment, it is characterised in that: institute
It states Peltier and is provided with the second cooling fin in the side outside temperature control compartment warehouse, be provided with second on the second cooling fin
Fan.
5. according to claim 4 for dry type fluorescence/colloid gold reagent card detection temperature control compartment, it is characterised in that: described
Second cooling fin is sun flower-shape fin, and the diameter of the second fan is equal to the diameter of sun flower-shape fin.
6. according to claim 1 for dry type fluorescence/colloid gold reagent card detection temperature control compartment, it is characterised in that: described
Peltier is made of semiconductor material or metal material.
7. according to claim 1 for dry type fluorescence/colloid gold reagent card detection temperature control compartment, it is characterised in that: described
Temperature control compartment warehouse also sets up the door that can be opened, be closed, and sticks into out temperature control compartment for dry type fluorescence/colloid gold reagent.
8. for dry type fluorescence/colloid gold reagent card detection temperature control method, which is characterized in that include the steps that following sequence:
Temperature control compartment required temperature is set according to actual needs, and temperature control compartment warehouse inner air is heated or made using Peltier
It is cold；It is specific as follows:
If Peltier forward direction is powered, heat to temperature control compartment warehouse inner air: temperature control compartment warehouse inner air needs to heat,
Then Peltier forward direction is powered；Temperature control compartment warehouse inner air needs to freeze, then Peltier is reversely powered；
If Peltier forward direction is powered, freeze to temperature control compartment warehouse inner air, similarly.
9. according to claim 8 for dry type fluorescence/colloid gold reagent card detection temperature control method, which is characterized in that also
The following steps are included:
When Peltier is powered, the first cooling fin, the first fan being close to inside temperature control compartment warehouse with Peltier work asynchronously；Together
When, the second cooling fin, the second fan that temperature control compartment warehouse outside is close to Peltier also work asynchronously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910476899.7A CN110045110A (en) | 2019-06-03 | 2019-06-03 | For dry type fluorescence/colloid gold reagent card detection temperature control compartment and temperature control method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910476899.7A CN110045110A (en) | 2019-06-03 | 2019-06-03 | For dry type fluorescence/colloid gold reagent card detection temperature control compartment and temperature control method |
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| Publication Number | Publication Date |
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| CN110045110A true CN110045110A (en) | 2019-07-23 |
Family
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| CN201910476899.7A Withdrawn CN110045110A (en) | 2019-06-03 | 2019-06-03 | For dry type fluorescence/colloid gold reagent card detection temperature control compartment and temperature control method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111322149A (en) * | 2020-02-27 | 2020-06-23 | 安徽安凯汽车股份有限公司 | Adjustable intelligent temperature control heat dissipation system |
| CN113533229A (en) * | 2021-06-25 | 2021-10-22 | 华东师范大学 | Portable temperature control device of spectrophotometer |
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| CN113533229A (en) * | 2021-06-25 | 2021-10-22 | 华东师范大学 | Portable temperature control device of spectrophotometer |
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Application publication date: 20190723 |