CN115267163A - Chemiluminescence immunoassay kit loading, mixing and refrigerating system - Google Patents
Chemiluminescence immunoassay kit loading, mixing and refrigerating system Download PDFInfo
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- CN115267163A CN115267163A CN202210715205.2A CN202210715205A CN115267163A CN 115267163 A CN115267163 A CN 115267163A CN 202210715205 A CN202210715205 A CN 202210715205A CN 115267163 A CN115267163 A CN 115267163A
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- reagent
- refrigerating
- air duct
- heat exchanger
- disk
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25B—REFRIGERATION MACHINES, PLANTS OR SYSTEMS; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS
- F25B21/00—Machines, plants or systems, using electric or magnetic effects
- F25B21/02—Machines, plants or systems, using electric or magnetic effects using Peltier effect; using Nernst-Ettinghausen effect
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02B—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO BUILDINGS, e.g. HOUSING, HOUSE APPLIANCES OR RELATED END-USER APPLICATIONS
- Y02B30/00—Energy efficient heating, ventilation or air conditioning [HVAC]
Abstract
The invention provides a loading, mixing and refrigerating system of a chemiluminescence immunoassay kit. The device comprises a reagent bin, a reagent disk, a driving device and a refrigerating device; the reagent bin is provided with an accommodating cavity, the top of the reagent bin is provided with a loading port, the bottom of the reagent bin is provided with a heat exchange port, and the heat exchange port is provided with a first air channel; the reagent tray is rotatably arranged in the accommodating cavity and is provided with a plurality of reagent box mounting positions at intervals; the driving device is arranged below the reagent bin and drives the reagent tray to rotate; the refrigerating device is located below the reagent bin, and a refrigerating part of the refrigerating device is located in the first air channel. According to the invention, the refrigerating part is arranged in the first air channel below the reagent bin, condensed water generated during heat exchange directly flows out from the first air channel, so that the reagent is not polluted, the accuracy of subsequent detection is ensured, the space of the reagent bin is not occupied, the required refrigerating power is reduced, the equipment cost is reduced while the structure compactness is improved, and the reagent disk is simple in rotating centering and rotating motion structure and small in rotational inertia.
Description
Technical Field
The invention relates to the technical field of chemical analysis, in particular to a loading, mixing and refrigerating system of a chemiluminescence immunoassay kit.
Background
In a chemiluminescence immunoassay analyzer, a kit needs to be loaded on the analyzer, and the kit is loaded in a blending and refrigerating device for blending and refrigerating at the same time, so that the reagent is prevented from settling and the stability of the loaded reagent is ensured, and therefore, the refrigerating link also plays a crucial role in the reliability of the whole analyzer.
However, the existing refrigerating devices of the reagent box loading, mixing and refrigerating equipment are all located in the reagent bin, and are particularly installed on the reagent tray, condensate generated in the refrigerating process is easy to drop into the reagent box, so that the reagent is polluted, the test result is influenced, even misjudgment of the negative and positive of a patient is caused, misdiagnosis is caused, and the refrigerating device occupies a large space of the reagent tray, so that the size of the reagent tray is large, the space utilization rate is low, the requirement on the refrigerating power of the refrigerating device is large, and the cost is increased. In addition, in the existing reagent mixing technology, the centering, fixing and rotating motion of the reagent disk mostly adopts a mode of matching a central main shaft of the reagent disk with a large bearing, and the design mode has the disadvantages of complex structure, high manufacturing cost, large moment of inertia, unsuitability for the situations of more reagent boxes and larger diameter of the reagent disk.
Disclosure of Invention
The invention aims to provide a chemiluminescent immunoassay kit loading, mixing and refrigerating system, which aims to solve the problems of easy reagent pollution, poor space utilization rate, high refrigerating cost, complex structure of centering and rotary motion of a reagent disk and high rotational inertia of the conventional kit loading, mixing and refrigerating equipment.
In order to solve the problems, the invention provides a chemiluminescent immunoassay kit loading, mixing and refrigerating system, which comprises a reagent bin, a reagent disk, a driving device and a refrigerating device, wherein the reagent bin is provided with a plurality of reagent disks; the reagent bin is provided with an accommodating cavity for accommodating a reagent disc, the top of the reagent bin is provided with a loading port for filling a reagent box, the bottom of the reagent bin is provided with a heat exchange port, and the heat exchange port is provided with a first air channel which is communicated with the accommodating cavity and extends downwards; the reagent disk can be axially and rotatably arranged in the accommodating cavity around the reagent disk, and a plurality of installation positions for installing the reagent kit are arranged at intervals; the driving device is arranged below the reagent bin and is in transmission connection with the reagent disk so as to drive the reagent disk to rotate; the refrigerating device is positioned below the reagent bin, and a refrigerating part of the refrigerating device is positioned in the first air duct; the axial support assembly and the radial support assembly are mounted in the accommodating cavity; the plurality of axial supporting assemblies are arranged at the outer edge of the accommodating cavity at intervals along the circumferential direction, and the plurality of radial supporting assemblies are arranged at the inner edge of the accommodating cavity at intervals along the circumferential direction; the reagent disk is arranged on the plurality of axial supporting assemblies, the bottom of the reagent disk is in rolling fit with the plurality of axial supporting assemblies, the inner ring inclined plane of the reagent disk is in rolling fit with the plurality of radial supporting assemblies, and the outer side of the reagent disk is in transmission connection with the driving device.
By adopting the technical scheme, the refrigerating part of the refrigerating device is arranged in the first air channel below the reagent bin, condensed water generated by the refrigerating part in the heat exchange process directly flows out of the first air channel, so that the reagent in the accommodating bin cannot be polluted, the accuracy of subsequent detection is ensured, the space in the reagent bin is not occupied, the refrigerating power required by the refrigerating device is reduced, the structural compactness is improved, and the equipment cost can be reduced; and the axial lower part position of the reagent disk is limited by the plurality of axial supporting components to play a role of axially supporting the reagent disk, the inclined planes through which the plurality of radial supporting components pass are matched with the inclined planes of the inner ring of the reagent disk, and the matching surfaces of the inclined planes and the inner ring of the reagent disk form an outward radial force and an axial downward force on the reagent disk, so that the rotation center position and the axial upper part position of the reagent disk are limited, the centering fixation and the rotary motion of the reagent disk are realized, the structure is simple, and the rotary inertia is small.
Further, the refrigerating device comprises a cold end heat exchanger, a refrigerating mechanism, a second air duct, a hot end heat exchanger and a heat insulation plate; the cold end heat exchanger is positioned in the first air duct, and the refrigerating mechanism is respectively connected with the cold end heat exchanger and the hot end heat exchanger; the second air duct is connected with the first air duct, and the hot-end heat exchanger is positioned in the second air duct; the heat insulation plate is positioned between the first air duct and the second air duct and isolates the hot end heat exchanger from the hot end heat exchanger.
Adopt above-mentioned technical scheme, utilize cold junction heat exchanger, refrigerating mechanism and hot junction heat exchanger to form the heat exchange circulation, the hot junction heat exchanger distributes the heat to the external world by the second wind channel, and the cold junction heat exchanger gets into the holding storehouse with cold air and then realizes cold-stored to the reagent bottle by the heat transfer mouth, and simple structure just has good radiating effect.
Furthermore, the first air duct is provided with a first air inlet and a first air outlet, and the second air duct is provided with a second air inlet and a second air outlet; the first air duct is internally provided with a first fan which leads air from the first air inlet to the first air outlet, and the second air duct is internally provided with a second fan which leads air from the second air inlet to the second air outlet.
By adopting the technical scheme, the air cooling structure is formed by the first fan, the second fan, the cold end heat exchanger, the refrigerating mechanism and the hot end heat exchanger, the cooling effect is superior to that of direct cooling, and the phenomenon that condensed water is deposited in the accommodating cavity cannot occur in comparison with the existing air cooling technology.
Furthermore, the number of the refrigerating devices is two, and the two refrigerating devices are respectively arranged on two sides below the reagent bin; the first air inlet of one of the refrigeration devices is arranged facing the first air outlet of the other refrigeration device.
By adopting the technical scheme, the air outlet direction of the refrigerating device on one side is close to the air inlet direction of the refrigerating device on the other side, so that the circulation of cold air in the reagent bin is facilitated, the refrigerating efficiency is higher, and the refrigeration is more balanced.
Further, the axial support assembly comprises a first support seat, a first rotating shaft and a first bearing; the reagent box comprises a reagent bin, a radial support assembly, a first support seat, a first bearing, a first support seat, a first rotating shaft, a first bearing, a first support seat, a second bearing, a second support seat and a reagent disk, wherein the first support seat is arranged in the reagent bin, one end of the first support seat, which deviates from the radial support assembly, is provided with a support wall which extends upwards, the first rotating shaft is arranged on one side, which deviates from the radial support assembly, of the support wall, the first bearing is sleeved on the first rotating shaft, and the reagent disk is arranged on the first bearing.
Adopt above-mentioned technical scheme, realize axial supporting component's relatively fixed through being connected of first supporting seat and reagent storehouse, the reagent dish is not only playing good supporting role around self axial rotation in-process first bearing, but also realized through the rotatable characteristic of bearing with the rolling friction of reagent dish, reduce the resistance of reagent dish rotation in-process.
Further, the radial support assembly comprises a second rotating shaft, a second bearing and a support wheel; the second bearing inner ring is sleeved on the second rotating shaft, the supporting wheel is sleeved on the second rotating shaft outer ring, and the inner side of the reagent disk abuts against the supporting wheel.
By adopting the technical scheme, the side part of the reagent disk is limited and supported by the supporting wheel, and the supporting wheel and the reagent disk are in rolling friction in the axial rotation process of the reagent disk, so that the resistance in the rotation process of the reagent disk is further reduced.
Furthermore, a fixed gear is installed in the reagent bin, the plurality of radial supporting assemblies are installed on the fixed gear, and the reagent box is provided with a matching gear and a rotating transmission assembly; the matching gear is respectively in transmission connection with the fixed gear and the rotating transmission assembly, and the rotating transmission assembly is used for driving at least one reagent bottle in the reagent box to rotate around the self axial direction.
Adopt above-mentioned technical scheme, when the reagent dish rotated, the kit rotated rather than synchronous, and then made the fixed gear can stir cooperation gear revolve, and then realized the rotation of reagent bottle, utilized a drive arrangement can realize promptly that the reagent bottle rotates along with the reagent dish, can realize the rotation of reagent bottle self again, has not only improved the mixing effect of reagent in the reagent bottle, has realized integrative multi-purpose moreover, and the structure is ingenious.
Furthermore, a plurality of positioning blocks are correspondingly arranged on the mounting positions one by one, and a plurality of reagent boxes are correspondingly mounted on the positioning blocks one by one; the outer wall of the positioning block is provided with a guide groove and an elastic guide piece, the guide groove comprises a vertical part and a horizontal part which are vertically connected, and the kit is provided with a guide column which is in sliding fit with the guide groove; wherein the resilient guide is configured to: when the guide post moves downwards to a first position along the opening end of the vertical part, the elastic guide piece is compressed, and when the guide post moves to the joint of the vertical part and the horizontal part from the first position, the elastic guide piece resets and drives the guide post to move to one end of the horizontal part, which is far away from the vertical part.
Adopt above-mentioned technical scheme, the cooperation that utilizes guide way, guide post and elastic guide piece not only is convenient for the installation location of kit, can realize the ascending locking of vertical side of kit moreover, has improved the stability of kit at the mixing in-process.
Furthermore, the driving device comprises a driving motor, a belt transmission assembly, a transmission shaft and a transmission gear which are sequentially connected in a transmission manner; the transmission shaft extends into the accommodating cavity and can be axially and rotatably arranged at the bottom of the reagent bin around the transmission shaft; the transmission gear is positioned in the accommodating cavity and synchronously rotates with the transmission shaft, and the reagent disk is provided with outer ring teeth meshed with the transmission gear.
By adopting the technical scheme, the reagent disk is driven to rotate by the driving motor, the belt transmission assembly, the transmission shaft and the transmission gear, and the transmission is stable.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
Fig. 1 is a schematic structural diagram (one) of a loading, mixing and refrigerating system of a chemiluminescence immunoassay kit provided by the embodiment of the invention;
FIG. 2 isbase:Sub>A cross-sectional view A-A of FIG. 1;
fig. 3 is a schematic structural diagram (two) of a loading, mixing and refrigerating system of the chemiluminescence immunoassay kit provided by the embodiment of the invention;
FIG. 4 is a schematic diagram of the cooperative relationship of a reagent disk, a radial support assembly and an axial support assembly provided by an embodiment of the present invention;
FIG. 5 is a schematic diagram of a refrigeration device according to an embodiment of the present invention;
FIG. 6 is a schematic structural diagram of another refrigeration device provided by an embodiment of the present invention;
FIG. 7 is a schematic structural view of an axial support assembly provided in accordance with an embodiment of the present invention;
FIG. 8 is a schematic structural view of a radial support assembly provided in accordance with an embodiment of the present invention;
FIG. 9 is a schematic structural diagram of a bottom plate, a reagent tray and a fixed gear provided in an embodiment of the present invention;
FIG. 10 is a schematic structural diagram of a kit and a positioning block provided in an embodiment of the present invention;
FIG. 11 is a schematic structural diagram of a kit provided in an embodiment of the present invention;
fig. 12 is a schematic structural diagram of a driving device according to an embodiment of the present invention.
Description of reference numerals:
100-a reagent bin; 110-annular top plate; 120-ring shaped base plate; 130-ring-shaped side plate; 140-a housing chamber; 150-a loading port; 160-a first air duct;
200-reagent tray; 210-a positioning block; 211-a guide slot; 212-a resilient guide; 220-outer ring teeth; 230-inner ring inclined plane;
300-a drive means; 310-a drive motor; 320-a belt drive assembly; 330-a transmission shaft; 340-a drive gear; 350-a sleeve;
400-a refrigeration device; 410-cold side heat exchanger; 420-a refrigeration mechanism; 430-a second air duct; 440-hot side heat exchanger; 450-a heat insulation plate; 460-a first fan; 470-a second fan;
500-an axial support assembly; 510-a first support; 511-a support wall; 520-a first shaft; 530-a first bearing;
600-a radial support assembly; 610-a second rotating shaft; 620-a second bearing; 630-support wheels;
700-fixed gear;
800-kit; 810-mating gears; 820-guide post.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention.
In view of the problems of reagent contamination by condensed water, poor space utilization rate, high refrigeration cost and the like of the existing reagent kit loading, mixing and refrigerating system, the embodiment provides a chemiluminescent immunoassay reagent kit loading, mixing and refrigerating system, and aims to solve the technical problems by improving the structure and the installation position of a refrigerating device.
Referring to fig. 1, fig. 2 and fig. 3, the chemiluminescent immunoassay kit loading, blending and refrigerating system according to this embodiment includes functional devices such as a reagent bin 100, a reagent tray 200, a driving device 300 and a refrigerating device 400, and in addition, a control device not shown in the drawings is further provided, the control device may be a part of the whole chemiluminescent immunoassay instrument or an independent controller, and the control device is connected with the refrigerating device 400 and the driving device 300 through wires or signals to control the opening and closing of the two devices.
The reagent cartridge 100 of the present embodiment is similar to a circular ring structure as a whole, and includes a circular top plate 110, a circular bottom plate 120, and two circular side plates 130 connected to the top plate and the bottom plate, where the circular top plate 110, the circular bottom plate 120, and the circular side plates 130 form a substantially circular accommodating cavity 140 for accommodating the reagent disk 200, a loading port 150 for loading the reagent cartridge 800 is disposed on the circular top plate 110, a heat exchanging port (not shown) is disposed on the circular bottom plate 120, and a first air duct 160 communicating with the accommodating cavity 140 and extending downward is disposed at the heat exchanging port.
Referring to fig. 2, the reagent disk 200 of this embodiment is mounted in the accommodating cavity 140 in a manner of rotating around its own axis, and a plurality of mounting positions for mounting the reagent cartridges 800 are arranged at intervals, and a plurality of reagent cartridges 800 can be mounted on the plurality of mounting positions in a one-to-one correspondence manner; the driving device 300 of the present embodiment is installed below the reagent cartridge 100 and is in transmission connection with the reagent disk 200 to drive the reagent disk 200 to rotate, and the specific transmission mode is given below.
The refrigerating device 400 of this embodiment is located reagent storehouse 100 below, and, it is located reagent storehouse 100 to be different from current refrigerating device 400, this embodiment is located first wind channel 160 with refrigerating device 400's refrigeration part, and then make the condensation water that refrigeration part produced in the heat transfer process directly form and flow in first wind channel 160, and can not cause the pollution to the reagent in the holding storehouse, the accuracy of follow-up detection has been ensured, and because refrigerating device 400 does not occupy reagent storehouse 100 space, required refrigeration power in the reagent storehouse 100 has been reduced, when improving compact structure, can reduce certain equipment cost.
Referring to fig. 5, the cooling device 400 of the present embodiment includes a cold-side heat exchanger 410, a cooling mechanism 420, a second air duct 430, a hot-side heat exchanger 440, and a heat insulation plate 450, where the cold-side heat exchanger 410 of the present embodiment is the above-mentioned "cooling portion", and thus the cold-side heat exchanger 410 is located in the first air duct 160; the refrigeration mechanism 420 of this embodiment may be a semiconductor refrigeration plate or other refrigeration structure capable of playing a role of heat exchange, and the semiconductor refrigeration plate is respectively connected to the cold-end heat exchanger 410 and the hot-end heat exchanger 440; in this embodiment, the second air duct 430 is connected to but not communicated with the first air duct 160, the hot side heat exchanger 440 is located in the second air duct 430, and the heat insulating plate 450 is located between the first air duct 160 and the second air duct 430 and insulates the hot side heat exchanger 440 from the hot side heat exchanger 440.
During specific refrigeration, the refrigeration mechanism 420 can transfer heat of the cold-end heat exchanger 410 to the hot-end heat exchanger 440, then the hot-end heat exchanger 440 discharges high-temperature air out of the second air duct 430, heat exchange circulation is formed by the cold-end heat exchanger 410, the refrigeration mechanism 420 and the hot-end heat exchanger 440, the hot-end heat exchanger 440 radiates heat from the second air duct 430 to the outside, the cold-end heat exchanger 410 enables cold air to enter the accommodating bin from the heat exchange port to further refrigerate the reagent bottle, the structure is simple, and a good heat radiation effect is achieved.
Based on the above-mentioned refrigeration apparatus 400, the first air duct 160 is further provided with a first air inlet and a first air outlet (not shown in the figure), the communication direction of the first air inlet and the first air outlet may be a horizontal direction, the second air duct 430 of this embodiment is provided with a second air inlet and a second air outlet (not shown in the figure), the communication direction of the second air inlet and the second air outlet is also a horizontal direction, in addition, the first air duct 160 is provided with a first fan 460 for introducing air from the first air inlet into the first air outlet, the second air duct 430 is provided with a second fan 470 for introducing air from the second air inlet into the second air outlet, an air cooling structure is formed by the first fan 460, the second fan 470, the cold-end heat exchanger 410, the refrigeration mechanism 420 and the hot-end heat exchanger 440, not only is better in cooling effect than the direct cooling technology, but also compared with the existing air cooling technology, a phenomenon that condensed water is deposited in the accommodating cavity 140 does not occur.
Optionally, the number of the refrigeration devices 400 of the embodiment is two, the two refrigeration devices 400 are respectively installed at two sides below the reagent chamber 100, and the first air inlet of one refrigeration device 400 is arranged facing the first air outlet of the other refrigeration device 400, and accordingly, the positions of the two first fans 460 need to be improved.
Referring to fig. 5 and fig. 6, on the basis that the two second fans 470 are located on the same side and the air outlet directions are the same, the first fan 460 of one of the refrigeration devices 400 is installed at one end of the cold-end heat exchanger 410 away from the second fan 470 in the horizontal direction, and the first fan 460 of the other refrigeration device 400 is installed at one end of the cold-end heat exchanger 410 close to the second fan 470 in the horizontal direction, so that the air outlet direction of the refrigeration device 400 on one side is close to the air inlet direction of the refrigeration device 400 on the other side, which is more beneficial to the circulation of cold air in the reagent chamber 100, and has higher refrigeration efficiency and more balanced refrigeration.
In addition, the inventor finds that in the existing reagent mixing technology, the centering, fixing and rotating motion of the reagent disk mostly adopts a mode of matching a central main shaft of the reagent disk with a large bearing, and the design mode has the disadvantages of complex structure, high manufacturing cost, large moment of inertia, unsuitability for the situations of more reagent cassettes and larger diameter of the reagent disk, so that the embodiment also improves the support for the rotation of the reagent disk.
With reference to fig. 2 and 4, the accommodating chamber 140 of the present embodiment is provided with an axial support assembly 500 and a radial support assembly 600; the plurality of axial support assemblies 500 are circumferentially arranged at intervals at the outer edge of the accommodating cavity 140, the plurality of radial support assemblies 600 are circumferentially arranged at intervals at the inner edge of the accommodating cavity 140, the reagent disk 200 of the present embodiment is mounted on the plurality of axial support assemblies 500, moreover, the bottom of the reagent disk 200 of the present embodiment is in rolling fit with the plurality of axial support assemblies 500, the inner side of the reagent disk 200 of the present embodiment is in rolling fit with the plurality of radial support assemblies 600, the outer side of the reagent disk 200 is in transmission connection with the driving device 300, and the plurality of axial support assemblies 500 define the lower fixing position of the reagent disk 200. The plurality of radial support members 600 are engaged with the inner ring inclined surface 230 of the reagent disk 200 by the inclined surfaces 630, and the engagement surfaces form an outward radial force and a downward force to the reagent disk, thereby defining the fixation of the center position and the upper position of the reagent disk 200 and ensuring the stability of the reagent disk 200 during the rotation.
Referring to fig. 7, the axial support assembly 500 of the present embodiment includes a first support base 510, a first rotating shaft 520 and a first bearing 530, specifically, the first support base 510 of the present embodiment is installed on the annular bottom plate 120 of the reagent cartridge 100, and the installation manner may be that the first support base 510 is connected by a connecting member such as a bolt, and the first support base 510 is an L-shaped plate, and one end of the first support base, which is away from the radial support assembly 600, is provided with a support wall 511 extending upward, the first rotating shaft 520 of the present embodiment is installed on one side of the support wall 511, which is away from the radial support assembly 600, the first bearing 530 is sleeved on the first rotating shaft 520, and the reagent disk 200 is installed on the first bearing 530.
The supporting component with the above structure realizes the relative fixation of the axial supporting component 500 through the connection of the first supporting seat 510 and the reagent bin 100, and the first bearing 530 not only plays a good supporting role in the process of rotating the reagent disk 200 around the self axial direction, but also realizes the rolling friction with the reagent disk 200 through the rotatable characteristic of the bearing, thereby reducing the resistance in the rotating process of the reagent disk 200.
As shown in fig. 8, the radial support assembly 600 of the present embodiment includes a second rotating shaft 610, a second bearing 620 and a support wheel 630; the second rotating shaft 610 of this embodiment is mounted on the fixed gear 700 described below, and no other mounting structure needs to be configured, the inner ring of the second bearing 620 of this embodiment is sleeved on the second rotating shaft 610, the supporting wheel 630 of this embodiment is sleeved on the outer ring of the second rotating shaft 610, the inner side of the reagent disk 200 abuts against the supporting wheel 630, the supporting wheel 630 is used to limit and support the side portion of the reagent disk 200, and the supporting wheel 630 and the reagent disk 200 are in rolling friction during the rotation of the reagent disk 200 around its own axial direction, so that the resistance during the rotation of the reagent disk 200 is further reduced.
Referring to fig. 2, 4 and 12, alternatively, the reagent cartridge 100 of this embodiment is provided with an annular fixed gear 700, the second rotating shafts 610 of the plurality of radial support assemblies 600 are all mounted on the fixed gear 700 and are arranged at intervals along the circumferential direction of the fixed gear 700, and accordingly, the reagent cartridge 800 of this embodiment is provided with a mating gear 810 and a rotation transmission assembly (not shown); the cooperation gear 810 is connected with fixed gear 700 and rotation transmission subassembly transmission respectively, rotates the transmission subassembly and is used for driving at least one reagent bottle in the kit 800 around self axial rotation, for example, the rotation transmission subassembly of this embodiment is a gear drive structure, can turn into the rotation of self gear with the rotation of cooperation gear 810, drives a reagent bottle rotation on it through self gear, of course, also can drive a plurality of reagent bottles through a plurality of gears of self and rotate.
Therefore, when the reagent disk 200 rotates, the reagent kit 800 rotates synchronously with the reagent kit, so that the fixed gear 700 can be used for stirring the matching gear 810 to rotate, the rotation of reagent bottles is realized, the reagent bottles can rotate along with the reagent disk 200 by using the driving device 300, the rotation of the reagent bottles can be realized, the uniform mixing effect of reagents in the reagent bottles is improved, and the reagent disk has the advantages of integration, multiple purposes and ingenious structure.
Referring to fig. 10 and 11, in the embodiment, a plurality of positioning blocks 210 are correspondingly arranged on the installation position one by one, a plurality of reagent cartridges 800 are correspondingly arranged on the plurality of positioning blocks 210 one by one, a guide groove 211 and an elastic guide 212 are arranged on the outer wall of each positioning block 210, each guide groove 211 comprises a vertical part and a horizontal part which are vertically connected, each reagent cartridge 800 is provided with a guide post 820 which is in sliding fit with the guide groove 211, and each elastic guide 212 is a torsion spring; also, the elastic guide 212 of the present embodiment is configured to: when the guide post 820 moves down to the first position along the open end of vertical portion, elastic guide 212 is compressed, when moving to vertical portion and horizontal part junction department by the first position, elastic guide 212 resets and drives guide post 820 and move to the one end that the horizontal part deviates from vertical portion, and thus, the cooperation of utilizing guide way 211, guide post 820 and elastic guide 212 not only is convenient for the installation location of kit 800, but also can realize the locking to kit 800 on the vertical side, has improved the stability of kit 800 in the mixing process.
Referring to fig. 12, the driving device 300 of the present embodiment includes a driving motor 310, a belt driving assembly 320, a driving shaft 330, a driving gear 340 and a sleeve 350, which are sequentially connected in a driving manner; the sleeve 350 of this embodiment is installed on the bottom surface of the annular bottom plate 120, the transmission shaft 330 of this embodiment is inserted into the sleeve 350, and extends into the accommodating cavity 140, and can be installed at the bottom of the reagent cartridge 100 around its own axial direction through a bearing, the transmission gear 340 of this embodiment is located in the accommodating cavity 140, and is installed at the top of the transmission shaft 330, the transmission gear 340 rotates synchronously with the transmission shaft 330, correspondingly, the outer edge of the reagent disk 200 of this embodiment is provided with outer ring teeth 220 meshed with the transmission gear 340, the reagent disk 200 is driven to rotate by the driving motor 310, the belt transmission assembly 320, the transmission shaft 330, and the transmission gear 340, and the transmission is stable.
In the description of this embodiment, it should be noted that, as those skilled in the art can understand, all or part of the processes in the method according to the above embodiments may be implemented by instructing a control device to implement the method according to the computer level, and the program may be stored in a computer-readable storage medium, and when executed, the program may include the processes according to the above method embodiments, where the storage medium may be a memory, a magnetic disk, an optical disk, or the like.
Although the present invention is disclosed above, the present invention is not limited thereto. Various changes and modifications may be effected by one skilled in the art without departing from the spirit and scope of the invention, as defined in the appended claims.
Finally, it should also be noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrases "comprising one of 8230; \8230;" 8230; "does not exclude the presence of additional like elements in a process, method, article, or apparatus that comprises the element.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (9)
1. The utility model provides a chemiluminescence immunoassay kit loads, mixing and refrigerating system which characterized in that includes:
the reagent box (100) is provided with a containing cavity (140) for containing a reagent disc (200), the top of the reagent box (100) is provided with a loading port (150) for filling a reagent box (800), the bottom of the reagent box (100) is provided with a heat exchange port, and the heat exchange port is provided with a first air duct (160) which is communicated with the containing cavity (140) and extends downwards;
the reagent disk (200) can rotate around the self axial direction and is arranged in the accommodating cavity (140), and a plurality of mounting positions for mounting the reagent box (800) are arranged at intervals;
the driving device (300) is arranged below the reagent bin (100) and is in transmission connection with the reagent disk (200) so as to drive the reagent disk (200) to rotate; and
a refrigeration device (400) located below the reagent cartridge (100), a refrigeration portion of the refrigeration device (400) being located within the first air duct (160);
wherein an axial support assembly (500) and a radial support assembly (600) are arranged in the accommodating cavity (140); the axial support assemblies (500) are arranged at the outer edge of the accommodating cavity (140) at intervals along the circumferential direction, and the radial support assemblies (600) are arranged at the inner edge of the accommodating cavity (140) at intervals along the circumferential direction; the reagent disk (200) is installed on the plurality of axial supporting assemblies (500), the bottom of the reagent disk (200) is in rolling fit with the plurality of axial supporting assemblies (500), an inner ring inclined surface (230) of the reagent disk (200) is in rolling fit with the plurality of radial supporting assemblies (600), and the outer side of the reagent disk (200) is in transmission connection with the driving device (300).
2. The chemiluminescent immunoassay kit loading, blending and cooling system of claim 1, wherein the cooling device (400) comprises a cold end heat exchanger (410), a cooling mechanism (420), a second air duct (430), a hot end heat exchanger (440) and a heat insulation board (450);
the cold-end heat exchanger (410) is positioned in the first air duct (160), and the refrigerating mechanism (420) is respectively connected with the cold-end heat exchanger (410) and the hot-end heat exchanger (440);
the second air duct (430) is connected with the first air duct (160), and the hot-end heat exchanger (440) is positioned in the second air duct (430);
the insulation panel (450) is positioned between the first air duct (160) and the second air duct (430) and insulates the hot side heat exchanger (440) from the hot side heat exchanger (440).
3. The chemiluminescent immunoassay kit loading, blending and refrigerating system of claim 2, wherein the first air duct (160) is provided with a first air inlet and a first air outlet, and the second air duct (430) is provided with a second air inlet and a second air outlet;
a first fan (460) for leading air from a first air inlet to a first air outlet is arranged in the first air duct (160), and a second fan (470) for leading air from a second air inlet to a second air outlet is arranged in the second air duct (430).
4. The chemiluminescent immunoassay kit loading, blending and refrigerating system according to claim 3, wherein the number of the refrigerating devices (400) is two, and the two refrigerating devices (400) are respectively arranged at two sides below the reagent bin (100);
the first air inlet of one refrigerating device (400) faces the first air outlet of the other refrigerating device (400).
5. The chemiluminescent immunoassay kit loading, blending and cooling system of claim 1 wherein the axial support assembly (500) comprises a first support base (510), a first rotating shaft (520) and a first bearing (530);
first supporting seat (510) install in reagent storehouse (100), first supporting seat (510) deviate from the one end of radial supporting component (600) is equipped with support wall (511) that upwards stretches out, first pivot (520) install in support wall (511) deviate from one side of radial supporting component (600), first bearing (530) suit in first pivot (520), install reagent dish (200) on first bearing (530).
6. The chemiluminescent immunoassay kit loading, blending and cooling system of claim 5 wherein the radial support assembly (600) comprises a second shaft (610), a second bearing (620) and a support wheel (630);
the inner ring of the second bearing (620) is sleeved on the second rotating shaft (610), the supporting wheel (630) is sleeved on the outer ring of the second rotating shaft (610), and the inner ring inclined surface (230) of the reagent disk (200) is abutted against the supporting wheel (630).
7. The chemiluminescent immunoassay kit loading, blending and cooling system of claim 1, wherein the reagent cartridge (100) is mounted with a fixed gear (700), a plurality of the radial support assemblies (600) are mounted on the fixed gear (700), the reagent cartridge (800) is provided with a mating gear (810) and a rotation transmission assembly;
the matching gear (810) is in transmission connection with the fixed gear (700) and the rotating transmission assembly respectively, and the rotating transmission assembly is used for driving at least one reagent bottle in the reagent box (800) to rotate around the axial direction of the reagent bottle.
8. The chemiluminescent immunoassay kit loading, mixing and refrigerating system according to any one of claims 1 to 7, wherein a plurality of positioning blocks (210) are correspondingly arranged on the mounting positions one by one, and a plurality of the kits (800) are correspondingly mounted on the plurality of positioning blocks (210) one by one;
the outer wall of the positioning block (210) is provided with a guide groove (211) and an elastic guide piece (212), the guide groove (211) comprises a vertical part and a horizontal part which are vertically connected, and the reagent kit (800) is provided with a guide column (820) which is in sliding fit with the guide groove (211);
wherein the resilient guide (212) is configured to: when the guide post (820) moves downwards to a first position along the opening end of the vertical part, the elastic guide piece (212) is compressed, and when the guide post moves to the joint of the vertical part and the horizontal part from the first position, the elastic guide piece (212) resets and drives the guide post (820) to move to one end of the horizontal part, which is far away from the vertical part.
9. The chemiluminescent immunoassay kit loading, mixing and refrigerating system according to any one of claims 1 to 7, wherein the driving device (300) comprises a driving motor (310), a belt driving component (320), a transmission shaft (330) and a transmission gear (340) which are in transmission connection in sequence;
the transmission shaft (330) extends into the accommodating cavity (140) and can be axially and rotatably arranged at the bottom of the reagent bin (100) around the transmission shaft;
the transmission gear (340) is located in the accommodating cavity (140) and rotates synchronously with the transmission shaft (330), and the reagent disk (200) is provided with outer ring teeth (220) meshed with the transmission gear (340).
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