CN108159316A - 一种治疗过敏性鼻炎的胶囊剂药物及制备方法 - Google Patents
一种治疗过敏性鼻炎的胶囊剂药物及制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂领域,目的是根据中医治疗过敏性鼻炎的认识机理而提供一种治疗过敏性鼻炎的胶囊剂药物,所述药物的各个组分及其质量份比如下:苍耳子80~150g、升麻30~80g、辛夷30~120g、蝉蜕30~80g、山茱萸50~120g、百合60~150g、鹅不食草60~100g、羌活30~120g、炙甘草30~130g、薏苡仁100~350g、荆芥穗50~120g、石菖蒲50~120g、露蜂房30~80g、神香草30~100g、唇香草150~200g、暴马子250~500g、通天草150~350g、卷柏50~120g;本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种治疗过敏性鼻炎的胶囊剂药物,特别是供过敏性鼻炎患者使用的胶囊剂药物及制备方法的领域。
背景技术
祖国医学认为:过敏性鼻炎即变应性鼻炎,是指特应性个体接触变应原后,主要由IgE介导的介质(主要是组胺)释放,并有多种免疫活性细胞和细胞因子等参与的鼻黏膜非感染性炎性疾病。其发生的必要条件有3个:特异性抗原即引起机体免疫反应的物质;特应性个体即所谓个体差异、过敏体质;特异性抗原与特应型个体二者相遇。变应性鼻炎是一个全球性健康问题,可导致许多疾病和劳动力丧失。
临床表现:
变应性鼻炎的典型症状主要是阵发性喷嚏、清水样鼻涕、鼻塞和鼻痒。部分伴有嗅觉减退。
A.喷嚏
每天数次阵发性发作,每次多于3个,多在晨起或者夜晚或接触过敏原后立刻发作。
B.清涕
大量清水样鼻涕,有时可不自觉从鼻孔滴下。
C.鼻塞
间歇或持续,单侧或双侧,轻重程度不一。
D.鼻痒
大多数患者鼻内发痒,花粉症患者可伴眼痒、耳痒和咽痒。
那么,就如何找到一种可有效治疗过敏性鼻炎的中药组合物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗过敏性鼻炎上,人们逐渐意识到了中医治疗过敏性鼻炎的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗过敏性鼻炎的现状,本发明的目的是在于提供一种治疗过敏性鼻炎的胶囊剂药物,以解决过敏性鼻炎患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述过敏性鼻炎。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种治疗过敏性鼻炎的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
苍耳子80~150g、升麻30~80g、辛夷30~120g、蝉蜕30~80g、山茱萸50~120g、百合60~150g、鹅不食草60~100g、羌活30~120g、炙甘草30~130g、薏苡仁100~350g、荆芥穗50~120g、石菖蒲50~120g、露蜂房30~80g、神香草30~100g、唇香草150~200g、暴马子250~500g、通天草150~350g、卷柏50~120g,辅料:滑石粉和淀粉适量。
一种治疗过敏性鼻炎的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
苍耳子90~130g、升麻38~70g、辛夷38~105g、蝉蜕38~70g、山茱萸58~105g、百合70~130g、鹅不食草70~90g、羌活38~105g、炙甘草38~115g、薏苡仁115~310g、荆芥穗58~105g、石菖蒲58~105g、露蜂房38~70g、神香草38~90g、唇香草160~190g、暴马子280~430g、通天草180~310g、卷柏58~105g,辅料:滑石粉和淀粉适量。
一种治疗过敏性鼻炎的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
苍耳子118g、升麻60g、辛夷95g、蝉蜕60g、山茱萸95g、百合118g、鹅不食草80g、羌活95g、炙甘草100g、薏苡仁280g、荆芥穗95g、石菖蒲95g、露蜂房60g、神香草80g、唇香草185g、暴马子360g、通天草280g、卷柏95g,辅料:滑石粉和淀粉适量。
一种治疗过敏性鼻炎的胶囊剂药物及制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质和粉尘后,按照质量份比共粉碎成粗粒状包煎;
B、将包好的原料中药放入冷开水中浸泡55min后,再将浸泡好的药物放入砂锅内煎煮三次:①加水量为药材总量的9~10倍,先进行武火煎煮,待煎煮到15min时,转文火熬制115min,滤取药液;②加水量为干药渣总量的8~9 倍,先进行武火煎煮,待煎煮到10min时,转文火熬制105 min,滤取药液;③加水量为干药渣总量的7~8 倍,先进行武火煎煮,待煎煮到8min时,转文火熬制90 min,滤取药液;④合并三次药液,并减压浓缩至每毫升含生药3g的标准后,即得到药物浸膏。
C、将上述B中制备好的浸膏干燥、消毒,并按照质量份比共研为极细末备用;
D、按照传统的常规工艺及辅料制备中药胶囊剂的方法,将C中研磨好的极细末药物过筛后,再将淀粉和滑石粉一并放入药器中混合均匀,然后制备成胶囊剂(其胶囊锁合后的总长度为23.3mm,药粉容量0.4~0.5g/粒),继而抛光、消毒,分装密封即得。
一种治疗过敏性鼻炎的胶囊剂药物及制备方法,其特征在于,所述服用方法为:将制备好的胶囊剂药物以每日三次服用,早中晚各服一次,给药量2g(4粒)/次,温开水送服。15天为一个疗程,治疗1~2个疗程,症状消失,病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
苍耳子,性味:味苦、甘、辛、性温,小毒,具有散风寒、通鼻窍、祛风湿、止痒之功效,用于治疗鼻渊、风寒头痛、风湿痹痛、风疹、湿疹、疥癣等症;
升麻,性味:辛、甘、微寒,具有发表透疹、清热解毒、升阳举陷之功效,用于治疗时气疫疠、头痛寒热、喉痛、口疮、斑疹不透、中气下陷、久泻久痢、脱肛、妇女崩、带、子宫下坠、痈肿疮毒;
辛夷,性味:辛、性温,具有散风寒、通鼻窍之功效,用于治疗鼻渊、风寒感冒之头痛、鼻塞、流涕等症;
蝉蜕,性味:味甘、咸、性凉,具有疏散风热、利咽开音、透疹、明目退翳、息风止痉之功效,用于治疗风热感冒、温病初起、咽痛音哑、麻疹不透、风疹瘙痒、目赤翳障、急慢惊风、破伤风证、小儿夜啼不安;
山茱萸,性味:味酸、性微温,具有补益肝肾、收敛固脱之功效,用于治疗腰头晕目眩、耳聋耳鸣、腰膝酸软、跹精滑精、小便频数、虚汗不止、妇女崩漏;
百合,性味:味甘、性寒,具有养阴润肺、清心安神之功效,用于治疗阴虚燥咳、劳嗽咳血、虚烦惊悸、失眠多梦、精神恍惚;
鹅不食草,性味:味辛、性温,具有发散风寒、通鼻窍、止咳之功效,用于治疗风寒头痛、咳嗽痰多、鼻塞不通、鼻渊流涕;
羌活,味辛、苦、性温,具有解表散寒、祛风胜湿、止痛之功效,用于治疗风寒感冒、风寒湿痹、项强筋急、骨节酸疼、风水浮肿、痈疽疮毒;
炙甘草,性味:甘、平,具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效,用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒,及药物、食物中毒;
薏苡仁,性味:甘、淡、微寒,具有利湿健脾、舒筋除痹、清热排脓之功效,用于治疗水肿、脚气、小便淋沥、湿温病、泄泻带下、风湿痹痛、筋脉拘挛、肺痈、肠痈、扁平疣等症;
荆芥穗,性味:辛、微温,具有解表散风、透疹、消疮之功效,用于治疗感冒、头痛、麻疹、风疹、疮疡初起;
石菖蒲,性味:辛、微温,具有开窍、豁痰、理气、活血、散风、去湿之功效,用于治疗癫痫、痰厥、热病神昏、健忘、气闭耳聋、心胸烦闷、胃痛、腹痛、风寒湿痹、痈疽肿毒、跌打损伤;
露蜂房,性味:甘、平,具有祛风、攻毒、杀虫、止痛、抗过敏之功效,用于治疗祛风镇痛、功毒散结、杀虫止痒;
神香草,性味:味辛、性凉,具有清热发表、化痰止咳之功效,用于治疗感冒发热、痰热咳嗽;
唇香草,性味:味辛、性寒,具有疏散风热、清利头目、于心安神、利水清热、壮骨强身、清胃消食之功效,用于治疗感冒发热、目赤肿痛、头痛、咽痛、心悸、失眠、水肿、疮疡肿毒、软骨病、阳痿、腻食不化;
暴马子,性味:苦、微寒,具有清肺祛痰、止咳平喘之功效,用于治疗咳嗽、支气管炎、支气管哮喘;
通天草,性味:味苦、性凉,具有清热解毒、利尿、降逆之功效,用于治疗热淋、小便不利、水肿、疔疮、呃逆等症;
卷柏,性味:味辛、性平,具有活血通经、卷柏炭化瘀止血之功效,用于治疗经闭痛经、瘕瘕痞块、跌扑损伤、卷柏炭用于吐血、崩漏、便血、脱肛等症。
本发明药物是基于中医治疗过敏性鼻炎的原则,从依据过敏性鼻炎的病理机制及药理作用认为:就过敏性鼻炎,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述过敏性鼻炎的治疗而提出的一种中药配方,采用该配方制备的药物药效好,见效快,是一个很好的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种治疗过敏性鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
苍耳子118g、升麻60g、辛夷95g、蝉蜕60g、山茱萸95g、百合118g、鹅不食草80g、羌活95g、炙甘草100g、薏苡仁280g、荆芥穗95g、石菖蒲95g、露蜂房60g、神香草80g、唇香草185g、暴马子360g、通天草280g、卷柏95g,辅料:滑石粉和淀粉适量。
实施例2:
一种治疗过敏性鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
苍耳子130g、升麻70g、辛夷105g、蝉蜕70g、山茱萸105g、百合130g、鹅不食草90g、羌活105g、炙甘草115g、薏苡仁310g、荆芥穗105g、石菖蒲105g、露蜂房70g、神香草90g、唇香草190g、暴马子430g、通天草310g、卷柏105g,辅料:滑石粉和淀粉适量。
实施例3:
一种治疗过敏性鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
苍耳子150g、升麻80g、辛夷120g、蝉蜕80g、山茱萸120g、百合150g、鹅不食草100g、羌活120g、炙甘草130g、薏苡仁350g、荆芥穗120g、石菖蒲120g、露蜂房80g、神香草100g、唇香草200g、暴马子500g、通天草350g、卷柏120g,辅料:滑石粉和淀粉适量。
典型病例:
经临床诊断治疗过敏性鼻炎患者共1247例,年龄为13岁以上的627例,只有620例为13岁以下。1247例患者中痊愈的有932例,有效的278例,无效的37例。总有效率达97%。
Claims (3)
1.一种治疗过敏性鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
苍耳子80~150g、升麻30~80g、辛夷30~120g、蝉蜕30~80g、山茱萸50~120g、百合60~150g、鹅不食草60~100g、羌活30~120g、炙甘草30~130g、薏苡仁100~350g、荆芥穗50~120g、石菖蒲50~120g、露蜂房30~80g、神香草30~100g、唇香草150~200g、暴马子250~500g、通天草150~350g、卷柏50~120g,辅料:滑石粉和淀粉适量。
2.根据权利要求1所述的治疗过敏性鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
苍耳子90~130g、升麻38~70g、辛夷38~105g、蝉蜕38~70g、山茱萸58~105g、百合70~130g、鹅不食草70~90g、羌活38~105g、炙甘草38~115g、薏苡仁115~310g、荆芥穗58~105g、石菖蒲58~105g、露蜂房38~70g、神香草38~90g、唇香草160~190g、暴马子280~430g、通天草180~310g、卷柏58~105g,辅料:滑石粉和淀粉适量。
3.根据权利要求1至2所述的治疗过敏性鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及其质量份比如下所示:
苍耳子118g、升麻60g、辛夷95g、蝉蜕60g、山茱萸95g、百合118g、鹅不食草80g、羌活95g、炙甘草100g、薏苡仁280g、荆芥穗95g、石菖蒲95g、露蜂房60g、神香草80g、唇香草185g、暴马子360g、通天草280g、卷柏95g,辅料:滑石粉和淀粉适量。
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