CN108159384A - 一种用于治疗过敏性鼻炎的胶囊剂药物及制备方法 - Google Patents
一种用于治疗过敏性鼻炎的胶囊剂药物及制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂领域,目的是根据中医治疗过敏性鼻炎的认识机理而提供一种用于治疗过敏性鼻炎的胶囊剂药物,所述药物的各个组分及其质量份比如下:黄芪100~380g、桂枝30~100g、白芍50~150g、白术80~160g、柴胡30~120g、辛夷30~120g、荆芥30~120g、苍耳子80~160g、当归80~160g、白芷30~120g、葶苈30~100g、藁本30~120g、蝉蜕30~70g、细辛20~100g、防风50~120g、远志30~100g、连翘60~160g、薄荷30~80g、生姜30~120g和炙甘草30~130g等;本发明提供的药物是一个很好的中药组方。
Description
技术领域
本发明属于中药制剂领域,具体涉及一种用于治疗过敏性鼻炎的胶囊剂药物,特别是供过敏性鼻炎患者使用的胶囊剂药物及制备方法的领域。
背景技术
祖国医学认为:过敏性鼻炎即变应性鼻炎,是指特应性个体接触变应原后,主要由IgE介导的介质(主要是组胺)释放,并有多种免疫活性细胞和细胞因子等参与的鼻黏膜非感染性炎性疾病。其发生的必要条件有三个:特异性抗原即引起机体免疫反应的物质;特应性个体即所谓个体差异、过敏体质;特异性抗原与特应型个体二者相遇。变应性鼻炎是一个全球性健康问题,可导致许多疾病和劳动力丧失。
临床表现:
变应性鼻炎的典型症状主要是阵发性喷嚏、清水样鼻涕、鼻塞和鼻痒。部分伴有嗅觉减退。
A.喷嚏
每天数次阵发性发作,每次多于3个,多在晨起或者夜晚或接触过敏原后立刻发作。
B.清涕
大量清水样鼻涕,有时可不自觉从鼻孔滴下。
C.鼻塞
间歇或持续,单侧或双侧,轻重程度不一。
D.鼻痒
大多数患者鼻内发痒,花粉症患者可伴眼痒、耳痒和咽痒。
那么,就如何找到一种可有效治疗过敏性鼻炎的中药组合物,是本领域技术人员亟待要解决的问题。
发明内容
随着我国中医中药学的不断发展,在治疗过敏性鼻炎上,人们逐渐意识到了中医治疗过敏性鼻炎的优点,且在治疗过程中疗效好、见效快、毒副作用小等优势,针对现有西医治疗过敏性鼻炎的现状,本发明的目的是在于提供一种用于治疗过敏性鼻炎的胶囊剂药物,以解决过敏性鼻炎患者早日恢复健康的问题。该药物是以常见的中药为原料,通过选择合理的药物及质量份比,可有效治疗上述过敏性鼻炎。
为达到上述发明的目的,本发明所采用的技术方案为:提供一种用于治疗过敏性鼻炎的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芪100~380g、桂枝30~100g、白芍50~150g、白术80~160g、柴胡30~120g、辛夷30~120g、荆芥30~120g、苍耳子80~160g、当归80~160g、白芷30~120g、葶苈30~100g、藁本30~120g、蝉蜕30~70g、细辛20~100g、防风50~120g、远志30~100g、连翘60~160g、薄荷30~80g、生姜30~120g、炙甘草30~130g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种用于治疗过敏性鼻炎的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芪118~320g、桂枝36~90g、白芍56~130g、白术90~140g、柴胡36~105g、辛夷36~105g、荆芥36~105g、苍耳子90~140g、当归90~140g、白芷36~105g、葶苈36~90g、藁本36~105g、蝉蜕36~60g、细辛26~90g、防风56~105g、远志36~90g、连翘70~140g、薄荷36~70g、生姜36~105g、炙甘草36~118g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种用于治疗过敏性鼻炎的胶囊剂药物及制备方法,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芪260g、桂枝80g、白芍118g、白术120g、柴胡95g、辛夷95g、荆芥95g、苍耳子120g、当归120g、白芷95g、葶苈80g、藁本95g、蝉蜕52g、细辛80g、防风95g、远志80g、连翘120g、薄荷60g、生姜95g、炙甘草100g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
一种用于治疗过敏性鼻炎的胶囊剂药物及制备方法,其特征在于,所述方法包括如下步骤制备而成:
A、将上述原料中药拣去杂质和粉尘后,按照质量份比共粉碎成(30~50目)颗粒状包煎;
B、①将包好的原料中药放入冷开水中浸泡40min,然后再将浸泡好的药物放入砂锅内,加入原料中药重量7~9倍的冷开水进行第一次武火煎煮,待煎煮到18min时,转文火熬制120min,滤取药液;②药渣中再次加入原料中药重量6~8 倍的冷开水进行第二次武火煎煮,待煎煮到15min时,转文火熬制110min,滤取药液;③将两次药液混合浓缩成相对密度为1.06~1.10(55℃)的浸膏后,经喷雾干燥,即得干浸膏,进而将干浸膏压成颗粒及消毒后备用;
C、①按照传统制备中药胶囊剂的方法,将B中研磨好的细末过筛后,加入适量的微粉硅胶、微晶纤维素和淀粉混合均匀,然后制备成胶囊剂(其胶囊锁合后总长度为23.3mm,药粉容量0.4~0.5g/粒),②继而抛光,消毒,分装密封即可。
一种用于治疗过敏性鼻炎的胶囊剂药物及制备方法,其特征在于,所述服用方法为:将制备好的胶囊剂药物以每日3次服用,早中晚各服一次,给药量2.4g(6粒)/次,温开水送服。8天为一疗程,服药1~2个疗程,症状明显减轻,病获痊愈。
本发明组方中的各原料中药在中国药典、中国辞典以及中华本草中均有详细的记载。本发明选用其中最常见的中药为原料,充分发挥各组分的药理功效:
黄芪,性味:甘、微温,具有补气固表、利尿托毒、排脓、敛疮生肌之功效,用于治疗气虚乏力、食少便溏、中气下陷、久泻脱肛、便血崩漏、表虚自汗、气虚水肿、痈疽难溃、久溃不敛、血虚痿黄、内热消渴、慢性肾炎蛋白尿、糖尿病等症;
桂枝,性味:辛、甘、温,具有发汗解肌、温通经脉、助阳化气、平冲降气之功效,用于治疗风寒感冒、脘腹冷痛、血寒经闭、关节痹痛、痰饮、水肿、心悸、奔豚等症;
白芍,性味:苦、酸、微寒,具有养血和营、缓急止痛、敛阴平肝之功效,用于治疗月经不调、经行腹痛、崩漏、自汗、盗汗、胁肋脘腹疼痛、四肢挛痛、头痛、眩晕等症;
白术,性味:味苦、甘、性温,具有健脾益气、燥湿利水、止汗、安胎之功效,用于治疗脾气虚弱、神疲乏力、食少少腹胀、大便溏薄、水饮内停、小便不利、水肿、痰饮眩晕、温痹酸痛、气虚自汗、胎动不安等症;
柴胡,性味:味苦、辛、性微寒,具有解表退热、疏肝解郁、升
举阳气之功效,用于治疗外感发热、寒热往来、疟疾、肝郁胁痛乳胀、头痛头眩、月经不调、气虚下陷之脱肛、子宫脱垂、胃下垂;
辛夷,性味:辛、性温,具有散风寒、通鼻窍之功效,用于治疗鼻渊、风寒感冒之头痛、鼻塞、流涕等症;
荆芥,性味:味辛、微苦、性微湿,具有祛风、解表、透疹、止血之功效,用于治疗感冒发热、头痛、目痒、咳嗽、咽喉肿痛、麻疹、痈肿、疮疥、衄血、吐血、便血、崩漏、产后血晕;
苍耳子,性味:味苦、甘、辛、性温,小毒,具有散风寒、通鼻窍、祛风湿、止痒之功效,用于治疗鼻渊、风寒头痛、风湿痹痛、风疹、湿疹、疥癣等症;
当归,性味:性温、味甘辛,具有补血和血、调经止痛、润燥滑肠之功效,用于治疗血虚、面色萎黄、眩晕心悸、血虚、或兼有瘀滞的月经不调、经闭、痛经、虚寒性腹痛、冠心病心绞痛、风湿痹痛、跌打损伤;
白芷,性味:味辛、性温,具有祛风除湿、通窃止痛、消肿排脓之功效,用于治疗感冒头痛、眉棱骨痛、牙痛、鼻塞、鼻渊、湿胜久泻、妇女白带、痈疽疮疡、毒蛇咬伤;
葶苈,性味:味辛、苦、性寒,具有破坚逐邪、泻肺行水、祛痰平喘之功效,用于治疗痰饮、咳喘、脘腹胀满、肺痈等症;
藁本,性味:味辛、性温,具有祛风散寒、除湿止痛之功效,用于治疗风寒表证、巅顶疼痛、风湿痹痛;
蝉蜕,性味:味甘、咸、性凉,具有疏散风热、利咽开音、透疹、明目退翳、息风止痉之功效,用于治疗风热感冒、温病初起、咽痛音哑、麻疹不透、风疹瘙痒、目赤翳障、急慢惊风、破伤风证、小儿夜啼不安;
细辛,性味:辛、温,具有祛风、散寒、行水、开窍之功效,用于治疗风冷头痛、鼻渊、齿痛、痰饮咳逆、风湿痹痛;
防风,性味:味辛、甘、性微温,具有祛风解表、胜湿止痛、解痉、止痒之功效,用于治疗外感风寒、头痛身痛、风湿痹痛、骨节酸痛、腹痛泄泻、肠风下血、破伤风、风疹瘙痒、疮疡初起等症;
远志,性味:味苦辛、性温,具有安神益智、祛痰、解郁之功效,用于治疗惊悸、健忘、梦遗、失眠、咳嗽多痰、痈疽疮肿;
连翘,性味:苦、凉,具有清热、解毒、散结、消肿之功效,用于治疗温热、丹毒、斑疹、痈疡肿毒、瘰疬、小便淋闭;
薄荷,性味:辛、凉,具有疏风、散热、辟秽、解毒之功效,用于治疗外感风热、头痛、目赤、咽喉肿痛、食滞气胀、口疮、牙痛、疮疥、瘾疹等症;
生姜,性味:味辛、性微温,具有解表散寒、温中止呕、温肺止咳、解毒之功效,用于治疗风寒感冒、脾胃寒症、胃寒呕吐、肺寒咳嗽、解鱼蟹毒等症;
炙甘草,性味:甘、平,具有益气补中、缓急止痛、润肺止咳、泻火解毒、调和诸药之功效,用于治疗倦怠食少、肌瘦面黄、心悸气短、腹痛便溏、四肢挛急疼痛、脏躁、咳嗽气喘、咽喉肿痛、痈疮肿痛、小儿胎毒,及药物、食物中毒。
本发明药物是基于中医治疗过敏性鼻炎的原则,从依据过敏性鼻炎的病理机制及药理作用认为:就过敏性鼻炎,本发明所提供的药物中的各原料中药药效共奏,对上述疾病有很好的治疗效果。
具体实施方式
本发明就是针对上述过敏性鼻炎的治疗而提出的一种用于中药配方,采用该配方制备的药物药效好,见效快,是一个很好的中药组方,特别适合临床使用。下面结合本发明的具体实施方式作进一步详细的描述:
实施例1:
一种用于治疗过敏性鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芪260g、桂枝80g、白芍118g、白术120g、柴胡95g、辛夷95g、荆芥95g、苍耳子120g、当归120g、白芷95g、葶苈80g、藁本95g、蝉蜕52g、细辛80g、防风95g、远志80g、连翘120g、薄荷60g、生姜95g、炙甘草100g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
实施例2:
一种用于治疗过敏性鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芪320g、桂枝90g、白芍130g、白术140g、柴胡105g、辛夷105g、荆芥105g、苍耳子140g、当归140g、白芷105g、葶苈90g、藁本105g、蝉蜕60g、细辛90g、防风105g、远志90g、连翘140g、薄荷70g、生姜105g、炙甘草118g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
实施例3:
一种用于治疗过敏性鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芪380g、桂枝100g、白芍150g、白术160g、柴胡120g、辛夷120g、荆芥120g、苍耳子160g、当归160g、白芷120g、葶苈100g、藁本120g、蝉蜕70g、细辛100g、防风120g、远志100g、连翘160g、薄荷80g、生姜120g、炙甘草130g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
典型病例:
经临床诊断治疗过敏性鼻炎患者共1260例,年龄为33岁以上的780例,只有480例为33岁以下。1260例患者中痊愈的有932例,有效的265例,无效的63例。总有效率达95%。
Claims (3)
1.一种用于治疗过敏性鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芪100~380g、桂枝30~100g、白芍50~150g、白术80~160g、柴胡30~120g、辛夷30~120g、荆芥30~120g、苍耳子80~160g、当归80~160g、白芷30~120g、葶苈30~100g、藁本30~120g、蝉蜕30~70g、细辛20~100g、防风50~120g、远志30~100g、连翘60~160g、薄荷30~80g、生姜30~120g、炙甘草30~130g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
2.根据权利要求1所述的用于治疗过敏性鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芪118~320g、桂枝36~90g、白芍56~130g、白术90~140g、柴胡36~105g、辛夷36~105g、荆芥36~105g、苍耳子90~140g、当归90~140g、白芷36~105g、葶苈36~90g、藁本36~105g、蝉蜕36~60g、细辛26~90g、防风56~105g、远志36~90g、连翘70~140g、薄荷36~70g、生姜36~105g、炙甘草36~118g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
3.根据权利要求1至2所述的用于治疗过敏性鼻炎的胶囊剂药物,其特征在于,所述药物的各个组分及质量份比如下所示:
黄芪260g、桂枝80g、白芍118g、白术120g、柴胡95g、辛夷95g、荆芥95g、苍耳子120g、当归120g、白芷95g、葶苈80g、藁本95g、蝉蜕52g、细辛80g、防风95g、远志80g、连翘120g、薄荷60g、生姜95g、炙甘草100g,辅料:微粉硅胶、微晶纤维素和淀粉适量。
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