CN107812084A - 一种治疗过敏性鼻炎的中药组合物及其制剂和应用 - Google Patents
一种治疗过敏性鼻炎的中药组合物及其制剂和应用 Download PDFInfo
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Abstract
本发明公开了一种治疗过敏性鼻炎的中药组合物及其制剂和应用，所述中药组合物包括以下重量份的原料药：北芪30～60g、白术15～30g、防风10～30g、熟地20～30g、淮山15～30g、山萸肉10～20g、炙麻黄10～15g、白芷10～20g、蝉蜕5～10g、炙甘草6～15g。方中以北芪、熟地、炙麻黄为君药，北芪补气固表、托毒生肌、利水消肿，熟地补血滋润，炙麻黄发汗散寒、利水消肿，以白术、淮山、山萸肉、白芷为臣药，白术健脾益气、燥湿利水，淮山健脾、补肺、益肾，山萸肉补益肝肾，白芷祛风散寒、通窍止痛、消肿排脓，以防风、蝉蜕为佐药，防风祛风解表、胜湿止痛，蝉蜕散风除热、透疹、解痉，以炙甘草为使药，炙甘草补脾益气、清热解毒、缓急止痛、调和诸药，对治疗过敏性鼻炎具有显著疗效。
Description
技术领域
本发明涉及中医药技术领域，尤其涉及一种治疗过敏性鼻炎的中药组合物及其制剂和应用。
背景技术
过敏性鼻炎即变应性鼻炎，是指特应性个体接触变应原后，主要由IgE介导的介质释放，并有多种免疫活性细胞和细胞因子等参与的鼻黏膜非感染性炎性疾病。过敏性鼻炎是一种由基因与环境互相作用而诱发的多因素疾病。变应性鼻炎的危险因素可能存在于所有年龄段。发病原因多为变应原暴露，变应原是诱导特异性IgE抗体并与之发生反应的抗原。变应原多来源于动物、植物、昆虫、真菌或职业性物质，其成分是蛋白质或糖蛋白，极少数是多聚糖。变应原主要分为吸入性变应原和食物性变应原。吸入性变应原包括虫螨、动物皮屑、花粉等，食物性变应原包括花生、牛奶、大豆、鸡蛋等。吸入性变应原是过敏性性鼻炎的主要原因。过敏性鼻炎是非严重的致命性疾病，容易被患者忽视和低估，但其病情反复，可显著影响病人生活质量，如影响睡眠，头晕脑胀，记忆力下降，导致工作效率下降，给社会活动、娱乐、工作都带来麻烦和不便。恼人的鼻部症状常使患者心情焦躁，甚至可引起心理障碍。过敏性鼻炎是一个全球性健康问题，世界各地均常见。目前，通常采用西药方法治疗，疗效欠佳，未能治本，且副作用大。故急需一种治疗过敏性鼻炎具有显著疗效的中药组合物。
发明内容
有鉴于此，本发明提供了一种治疗过敏性鼻炎的中药组合物及其制剂和应用，所述中药组合物科学配伍，各组分相互协同作用，对治疗过敏性鼻炎具有极佳的疗效，且服用安全。
本发明采用的技术手段如下：一种治疗过敏性鼻炎的中药组合物，包括以下重量份的原料药：北芪30～60g、白术15～30g、防风10～30g、熟地20～30g、淮山15～30g、山萸肉10～20g、炙麻黄10～15g、白芷10～20g、蝉蜕5～10g、炙甘草6～15g。
进一步的，所述的治疗过敏性鼻炎的中药组合物，包括以下重量份的原料药：北芪40～50g、白术20～25g、防风15～25g、熟地22～28g、淮山20～25g、山萸肉12～18g、炙麻黄12～14g、白芷12～18g、蝉蜕6～9g、炙甘草8～12g。
进一步的，所述的治疗过敏性鼻炎的中药组合物，包括以下重量份的原料药：北芪45g、白术22g、防风20g、熟地25g、淮山22g、山萸肉15g、炙麻黄13g、白芷15g、蝉蜕8g、炙甘草10g。
本发明还提供了一种治疗过敏性鼻炎的中药组合物制剂，包含权利要求1～3任一项所述的治疗过敏性鼻炎的中药组合物，所述治疗过敏性鼻炎的中药组合物制剂为汤剂、颗粒剂、口服液、丸剂、胶囊剂的一种。
本发明还提供了所述的治疗过敏性鼻炎的中药组合物在制备治疗过敏性鼻炎的药物中的应用。
以下依据《中国药典》、《中药大辞典》以及《中华草本》介绍主要原料药的性味、归经、功能和应用等基本情况。
北芪：【性味归经】甘，微温。归脾、肺经。【主治】脾肺气虚所致的食少便溏、气短乏力等证；中气下陷所致的久泻脱肛、子宫脱垂、脏器下垂(胃下垂等)等证；气虚不能摄血所致的便血、崩漏等证；卫气不固所致的表虚自汗；气血不足所致的痈疽不溃或溃久不敛；气虚失运所致的浮肿尿少；气虚血滞所致的肢体麻木、关节痹痛、半身不遂等证；气虚津亏所致的消渴证等。
白术：【性味归经】苦、甘，温。归脾、胃经。【功能主治】健脾益气，燥湿利水，止汗，安胎。用于脾虚食少，腹胀泄泻，痰饮眩悸，水肿，自汗，胎动不安。
防风：【性味归经】味辛、甘，性微温。归膀胱、肝、脾经。【功效】祛风解表，胜湿止痛，止痉。【主治】外感表证，风疹瘙痒，风湿痹痛，破伤风。
熟地：【性味归经】味甘；性温。归肝；肾经。【功能主治】补血滋润；益精填髓。用于血虚萎黄；眩晕心悸；月经不调；崩不止；肝肾阴亏；潮热盗汗；遗精阳痿；不育不孕；月经不调；崩漏下血；腰膝酸软；耳鸣耳聋；头目昏花；须发早白；消渴；便秘；肾虚喘促。
淮山：【性味归经】性平味甘；归经：胃经、肺经、脾经、肾经。【功能主治】健脾、厚肠胃、补肺、益肾。脾虚泄泻，久痢，虚劳咳嗽，遗精带下，小便频数，消渴，子宫脱垂。
山萸肉：【性味归经】酸、涩，微温。归肝、肾经。【功能主治】补益肝肾，涩精固脱。用于眩晕耳鸣，腰膝酸痛，阳痿遗精，遗尿尿频，崩漏带下，大汗虚脱。内热消渴。
炙麻黄：【性味与归经】辛、微苦，温。归肺、膀胱经。【功能与主治】发汗散寒，宣肺平喘，利水消肿。用于风寒感冒，胸闷喘咳，风水浮肿；支气管哮喘。蜜麻黄润肺止咳，多用于表症已解，气喘咳嗽。
白芷：【性味归经】辛，温。归肺、胃经。【功效】祛风散寒，通窍止痛，消肿排脓，燥湿止带。
蝉蜕：【性味归经】甘，寒。归肺、肝经。【功能主治】散风除热，利咽，透疹，退翳，解痉。用于风热感冒，咽痛，音哑，麻疹不透，风疹瘙痒，目赤翳障，惊风抽搐，破伤风。
炙甘草：【性味归经】性平味甘；胃经、肺经、脾经。【功能主治】补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒，缓解药物毒性、烈性。
与现有技术相比，本发明的有益效果是：本发明提供的一种治疗过敏性鼻炎的中药组合物，主要是依据过敏性鼻炎的病机特点研制而成，方中以北芪、熟地、炙麻黄为君药，北芪补气固表、托毒生肌、利水消肿，熟地补血滋润，炙麻黄发汗散寒、利水消肿，以白术、淮山、山萸肉、白芷为臣药，白术健脾益气、燥湿利水，淮山健脾、补肺、益肾，山萸肉补益肝肾，白芷祛风散寒、通窍止痛、消肿排脓，以防风、蝉蜕为佐药，防风祛风解表、胜湿止痛，蝉蜕散风除热、透疹、解痉，以炙甘草为使药，炙甘草补脾益气、清热解毒、缓急止痛、调和诸药。本发明科学配伍，各组分相互协同作用，对治疗过敏性鼻炎具有极佳的疗效，显效率高达92％、总有效率高达100％，且服用安全。本发明的中药组合物可应用于制备治疗过敏性鼻炎的药物。另外，本发明的中药组合物可制成多种剂型，对治疗过敏性鼻炎均具有很好的效果，可满足不同患者的需求。
具体实施方式
以下对本发明的原理和特征进行描述，所举实施例只用于解释本发明，并非用于限定本发明的范围。
实施例1
一种治疗过敏性鼻炎的中药组合物，包括以下重量的原料药：北芪30g、白术15g、防风10g、熟地20g、淮山15g、山萸肉10g、炙麻黄10g、白芷10g、蝉蜕5g、炙甘草6g。
实施例2
一种治疗过敏性鼻炎的中药组合物，包括以下重量的原料药：北芪60g、白术30g、防风30g、熟地30g、淮山30g、山萸肉20g、炙麻黄15g、白芷20g、蝉蜕10g、炙甘草15g。
实施例3
一种治疗过敏性鼻炎的中药组合物，包括以下重量的原料药：北芪40g、白术20g、防风15g、熟地22g、淮山20g、山萸肉12g、炙麻黄12g、白芷12g、蝉蜕6g、炙甘草8g。
实施例4
一种治疗过敏性鼻炎的中药组合物，包括以下重量的原料药：北芪50g、白术25g、防风25g、熟地28g、淮山25g、山萸肉18g、炙麻黄14g、白芷18g、蝉蜕9g、炙甘草12g。
实施例5
一种治疗过敏性鼻炎的中药组合物，包括以下重量的原料药：北芪45g、白术22g、防风20g、熟地25g、淮山22g、山萸肉15g、炙麻黄13g、白芷15g、蝉蜕8g、炙甘草10g。
对比例1
一种治疗过敏性鼻炎的中药组合物，包括以下重量的原料药：北芪65g、白术10g、防风35g、熟地15g、淮山35g、山萸肉25g、炙麻黄20g、白芷5g、蝉蜕15g、炙甘草20g。
一、临床资料
1、基本资料：共收集过敏性鼻炎患者600例，随机分为6组，试验组1～试验组6，每组100例。
2、临床表现：过敏性鼻炎的典型症状主要是阵发性喷嚏、清水样鼻涕、鼻塞和鼻痒。部分伴有嗅觉减退。
①喷嚏：每天数次阵发性发作，每次多于3个，多在晨起或者夜晚或接触过敏原后立刻发作。
②清涕：大量清水样鼻涕，有时可不自觉从鼻孔滴下。
③鼻塞：间歇或持续，单侧或双侧，轻重程度不一。
④鼻痒：大多数患者鼻内发痒，花粉症患者可伴眼痒、耳痒和咽痒。
3、排除病例：急性鼻炎卡他期、脑脊液鼻漏及血管运动性鼻炎。
二、诊断标准
临床症状喷嚏、清水样涕、鼻塞、鼻痒等症状出现2项以上(含2项)，每天症状持续或累计在1小时以上。可伴有眼痒、结膜充血等眼部症状。体征常见鼻黏膜苍白、水肿、鼻腔水样分泌物。变应原皮肤点刺试验阳性，和/或血清特异性IgE阳性，必要时可行鼻激发试验。
三、治疗方法
药物：采用本发明实施例1～5以及对比例1的中药组合物，实施例1～5以及对比例1的中药组合物依次对应病例组1～6。用药方法：日1剂，水煎温服用，7天为一个疗程，服用1～3个疗程。
四、治疗结果
1、疗效评分表
疗效指数(n)＝[(治疗前总分-治疗后总分)÷治疗前总分]×100％
显效：疗效指数≥66％。
有效：疗效指数≥26％，且＜66％。
无效：疗效指数＜26％。
(注：显效与有效之和为总有效率)
2、治疗效果
| 显效(例) | 有效(例) | 无效(例) | 总有效率(％) | |
| 实施例1 | 89 | 10 | 1 | 99 |
| 实施例2 | 90 | 8 | 2 | 98 |
| 实施例3 | 92 | 8 | 0 | 100 |
| 实施例4 | 90 | 9 | 1 | 99 |
| 实施例5 | 90 | 10 | 0 | 100 |
| 对比例1 | 19 | 43 | 38 | 62 |
上述通过临床试验表明，本发明提供的一种治疗过敏性鼻炎的中药组合物对治疗过敏性鼻炎具有良好的疗效，其治疗过敏性鼻炎的显效率高达92％、总有效率高达100％。其中，实施例5的疗效最佳，表明实施例5的各组分的重量比是最优选的，使得各组分协同作用最佳。根据对比例1的治疗效果，可知，表明本发明各组份的重量份比，对疗效有极大的影响。本发明科学配比，获得的中药组合物，治疗过敏性鼻炎疗效佳。
六、典型病例
1、周某，女，18岁，患有过敏性鼻炎有2年，常年流清鼻涕。服用本发明实施例1的中药组合物汤剂，治疗1个疗程后，好转，又服1个疗程后痊愈，随访停药半年来无复发。
2、冯某，女，35岁，患有过敏性鼻炎有8年，常在春秋季发病，发病时鼻塞鼻痒，打喷嚏，流鼻涕，流眼泪，头疼脑胀。服用本发明实施例3的中药组合物汤剂，治疗1个疗程后，好转，又服1个疗程后痊愈，随访停药半年来无复发。
3、冯某，男，27岁，患有过敏性鼻炎有10年，时常鼻痒、流清鼻涕、打喷嚏。半个月前突然加重，常常喷嚏连续不断，鼻塞也加重，常常需要张口呼吸，嗅觉减退，严重影响日常生活。服用本发明实施例5的中药组合物汤剂，治疗1个疗程后，好转，又服1个疗程后痊愈，之后继续服用1个疗程巩固疗效，随访停药半年来无复发。
七、不良反应观察
在治疗观察病例中，未发现有不良反应患者，表明本发明的一种治疗过敏性鼻炎的中药组合物安全可靠。
在另外的实施例中，本发明的一种治疗过敏性鼻炎的中药组合物通过常规方法制备成颗粒剂、口服液、丸剂、胶囊剂，治疗过敏性鼻炎均具有很好的效。
综上所述，本发明提供的一种治疗过敏性鼻炎的中药组合物，主要是依据过敏性鼻炎的病机特点研制而成，方中以北芪、熟地、炙麻黄为君药，北芪补气固表、托毒生肌、利水消肿，熟地补血滋润，炙麻黄发汗散寒、利水消肿，以白术、淮山、山萸肉、白芷为臣药，白术健脾益气、燥湿利水，淮山健脾、补肺、益肾，山萸肉补益肝肾，白芷祛风散寒、通窍止痛、消肿排脓，以防风、蝉蜕为佐药，防风祛风解表、胜湿止痛，蝉蜕散风除热、透疹、解痉，以炙甘草为使药，炙甘草补脾益气、清热解毒、缓急止痛、调和诸药。本发明科学配伍，各组分相互协同作用，对治疗过敏性鼻炎具有极佳的疗效，显效率高达92％、总有效率高达100％，且服用安全。本发明的中药组合物可应用于制备治疗过敏性鼻炎的药物。另外，本发明的中药组合物可制成多种剂型，对治疗过敏性鼻炎均具有很好的效果，可满足不同患者的需求。
以上所述仅为本发明的较佳实施例而已，并不用以限制本发明，凡在本发明的精神和原则之内，所做的任何修改、等同替换、改进等，均应包含在本发明保护的范围之内。
Claims (5)
1.一种治疗过敏性鼻炎的中药组合物，其特征在于，包括以下重量份的原料药：北芪30～60g、白术15～30g、防风10～30g、熟地20～30g、淮山15～30g、山萸肉10～20g、炙麻黄10～15g、白芷10～20g、蝉蜕5～10g、炙甘草6～15g。
2.根据权利要求1所述的治疗过敏性鼻炎的中药组合物，其特征在于，包括以下重量份的原料药：北芪40～50g、白术20～25g、防风15～25g、熟地22～28g、淮山20～25g、山萸肉12～18g、炙麻黄12～14g、白芷12～18g、蝉蜕6～9g、炙甘草8～12g。
3.根据权利要求1所述的治疗过敏性鼻炎的中药组合物，其特征在于，包括以下重量份的原料药：北芪45g、白术22g、防风20g、熟地25g、淮山22g、山萸肉15g、炙麻黄13g、白芷15g、蝉蜕8g、炙甘草10g。
4.一种治疗过敏性鼻炎的中药组合物制剂，其特征在于，包含权利要求1～3任一项所述的治疗过敏性鼻炎的中药组合物，所述治疗过敏性鼻炎的中药组合物制剂为汤剂、颗粒剂、口服液、丸剂、胶囊剂的一种。
5.权利要求1～3任一项所述的治疗过敏性鼻炎的中药组合物在制备治疗过敏性鼻炎的药物中的应用。
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| CN112717113A (zh) * | 2021-01-29 | 2021-04-30 | 吴�灿 | 一种治疗过敏性鼻炎中药组合物及其膏方和应用 |
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| CN112717113A (zh) * | 2021-01-29 | 2021-04-30 | 吴�灿 | 一种治疗过敏性鼻炎中药组合物及其膏方和应用 |
| CN112717113B (zh) * | 2021-01-29 | 2022-06-14 | 吴�灿 | 一种治疗过敏性鼻炎中药组合物及其膏方和应用 |
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