CN108157949A - A kind of spot-eliminating beauty treatment capsule and preparation method thereof - Google Patents
A kind of spot-eliminating beauty treatment capsule and preparation method thereof Download PDFInfo
- Publication number
- CN108157949A CN108157949A CN201810001610.1A CN201810001610A CN108157949A CN 108157949 A CN108157949 A CN 108157949A CN 201810001610 A CN201810001610 A CN 201810001610A CN 108157949 A CN108157949 A CN 108157949A
- Authority
- CN
- China
- Prior art keywords
- capsule
- parts
- spot
- beauty treatment
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 95
- 230000003796 beauty Effects 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 239000000843 powder Substances 0.000 claims abstract description 54
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 52
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 50
- 244000181025 Rosa gallica Species 0.000 claims abstract description 28
- 235000000533 Rosa gallica Nutrition 0.000 claims abstract description 28
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 26
- GSSMIHQEWAQUPM-AOLPDKKJSA-N ovalbumin peptide Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CN=CN1 GSSMIHQEWAQUPM-AOLPDKKJSA-N 0.000 claims abstract description 26
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 25
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 24
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 24
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 24
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 22
- 238000011049 filling Methods 0.000 claims abstract description 18
- 239000011812 mixed powder Substances 0.000 claims abstract description 18
- 238000002156 mixing Methods 0.000 claims abstract description 10
- 238000003860 storage Methods 0.000 claims abstract description 9
- 238000012856 packing Methods 0.000 claims description 45
- 238000005498 polishing Methods 0.000 claims description 25
- 239000005030 aluminium foil Substances 0.000 claims description 18
- 239000004033 plastic Substances 0.000 claims description 18
- 238000007789 sealing Methods 0.000 claims description 18
- 238000007689 inspection Methods 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 7
- 238000011068 loading method Methods 0.000 claims description 2
- VDGJOQCBCPGFFD-UHFFFAOYSA-N oxygen(2-) silicon(4+) titanium(4+) Chemical compound [Si+4].[O-2].[O-2].[Ti+4] VDGJOQCBCPGFFD-UHFFFAOYSA-N 0.000 claims 1
- 208000003351 Melanosis Diseases 0.000 abstract description 9
- 238000004806 packaging method and process Methods 0.000 abstract description 7
- 210000004185 liver Anatomy 0.000 abstract description 4
- 206010008570 Chloasma Diseases 0.000 abstract description 3
- 239000006210 lotion Substances 0.000 abstract description 3
- 230000001151 other effect Effects 0.000 abstract description 3
- 230000002936 tranquilizing effect Effects 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 14
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 10
- 239000003814 drug Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 238000002835 absorbance Methods 0.000 description 6
- 235000013305 food Nutrition 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000000686 essence Substances 0.000 description 4
- 230000007062 hydrolysis Effects 0.000 description 4
- 238000006460 hydrolysis reaction Methods 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000012797 qualification Methods 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 239000011573 trace mineral Substances 0.000 description 3
- 235000013619 trace mineral Nutrition 0.000 description 3
- 230000002087 whitening effect Effects 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 102000019197 Superoxide Dismutase Human genes 0.000 description 2
- 108010012715 Superoxide dismutase Proteins 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 241000790917 Dioxys <bee> Species 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 229910003978 SiClx Inorganic materials 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 238000001354 calcination Methods 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 208000030159 metabolic disease Diseases 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- -1 poly butylene succinate Polymers 0.000 description 1
- 239000004631 polybutylene succinate Substances 0.000 description 1
- 229920002961 polybutylene succinate Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- CEIZFXOZIQNICU-UHFFFAOYSA-N tenuazonic acid Chemical compound CCC(C)C1NC(=O)C(C(C)=O)=C1O CEIZFXOZIQNICU-UHFFFAOYSA-N 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 238000002525 ultrasonication Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a kind of spot-eliminating beauty treatment capsule and preparation method thereof, in parts by weight, including following component：0.1~0.5 part of 20~60 parts of polyphyll petal of red rose powder, 20~60 parts of hydrolyzed pearl powder, 10~20 parts of ovalbumin peptide, 1~2 part of maltodextrin, 0.5~1 part of silica and magnesium stearate；Preparation process is as follows：Prepare the polyphyll petal of red rose powder, hydrolyzed pearl powder, ovalbumin peptide, maltodextrin, magnesium stearate and the silica that meet quality criteria requirements；It weighs, is placed in hopper mixing machine in parts by weight, obtain total mixed powder；Total mixed powder is loaded into capsule；Capsule after filling is polished, packaging, is examined, storage.Spot-eliminating beauty treatment capsule provided by the invention has soothing liver-qi stagnation, soothing the liver tranquilizing the mind, functions of removing chloasma, beautifying face and moistering lotion and other effects.
Description
Technical field
The invention belongs to nti-freckle product technical fields, and in particular to a kind of spot-eliminating beauty treatment capsule and preparation method thereof.
Background technology
Pigmented mark is that pigmented spots occur, and pigmented spots refer to that dermal melanin distribution of particles is uneven, lead to office
There is spot, the patch than normal skin tone depth compared with other positions depth, part in portion's skin color.The existing pigmented side for the treatment of
Method is divided into cold therapy, and calcination, laser nti-freckle etc. is smeared in electric burning, and the stimulation of these method generally existings is big, destroys skin screen
Barrier, easily repeatedly the shortcomings of.The relatively safe at present and suitable nti-freckle method generally used is to use eliminating spots and moisturizing skin whitening preparation.So
And existing eliminating spots and moisturizing skin whitening preparation, most complicated component containing irritant chemical composition, easily cause skin in the market
Allergy.
Therefore, either cold therapy, laser nti-freckle or use eliminating spots and moisturizing skin whitening preparation, all only in skin table
Face is worked, and can not be accelerated body metabolism from body interior needs, exclude vivotoxin in time, be really achieved elimination
Spot, the purpose not recurred, unlikely achieve the effect that health care.In consideration of it, there is an urgent need for one kind from body interior, it is stingless
Swash, do not recur, fundamentally change skin metabolism disorder, the spot-eliminating beauty treatment capsule of melanin pigmentation phenomenon, while be used as health care
Food consumption.
Invention content
The technical problems to be solved by the invention are to provide a kind of food using natural food and integration of drinking and medicinal herbs and prepare
Spot-eliminating beauty treatment capsule, it is directly oral, there is soothing liver-qi stagnation, soothing the liver tranquilizing the mind, functions of removing chloasma, beautifying face and moistering lotion and other effects.
To achieve the above object, the present invention uses following technical scheme：
A kind of spot-eliminating beauty treatment capsule, in parts by weight, including following component：20~60 parts of polyphyll petal of red rose powder, water
Solve 20~60 parts of pearl powder, 10~20 parts of ovalbumin peptide, 2~4 parts of auxiliary material.
Polyphyll red rose contain protein, fat, carbohydrate, more than ten kinds of amino acid, soluble sugar, alkaloid with
And various trace elements, and Vitamin C content is high, and the often feeding polyphyll red rose liver that can relax is waken up stomach, and promoting blood circulation of having a respite, beauty is supported
Face.
Hydrolyzed pearl powder can promote neonatal cell to synthesize, and constantly add to skin surface, make skin smooth, exquisiteness,
It is flexible；Pearl powder contains the trace element of superoxide dismutase synthesis, can promote the synthesis of superoxide dismutase, so as to
Reach removing interior free yl, prevent skin aging and pigmented effect.It can also eliminate nervous fatigue, mental-tranquilization.
Ovalbumin peptide is able to maintain that plasma osmolarity, increases blood volume, promotes the absorption of the nucleic acid in food.
Preferably, a kind of spot-eliminating beauty treatment capsule, in parts by weight, including following component：40 parts of polyphyll petal of red rose powder,
40 parts of hydrolyzed pearl powder, 20 parts of ovalbumin peptide, 3 parts of auxiliary material.
Polyphyll petal of red rose powder, hydrolyzed pearl powder and ovalbumin peptide are used in combination, and can provide for body-care
Amino acid, soluble sugar, alkaloid, vitamin C and various trace elements, moreover it can be used to which spot-eliminating beauty treatment does not recur, no secondary work
With.
Preferably, a kind of spot-eliminating beauty treatment capsule, in parts by weight, auxiliary material include 1~2 part of maltodextrin, silica 0.5
~1 part and 0.5~1 part of magnesium stearate.
Maltodextrin solubility property is good, there is appropriate viscosity, promotes formed product, is easily absorbed by the body；Titanium dioxide
Silicon can shorten the disintegration time limited of drug, so as to improve drug-eluting speed, as lubricant, antiplastering aid, glidant；Stearic acid
Magnesium is used as stabilizer and lubricant.
Preferably, a kind of spot-eliminating beauty treatment capsule, in parts by weight, auxiliary material include 1.5 parts of maltodextrin, silica 1 part
With 0.5 part of magnesium stearate.
Preferably, a kind of preparation method of spot-eliminating beauty treatment capsule, is as follows：
(1) prepare the polyphyll petal of red rose powder, hydrolyzed pearl powder, ovalbumin peptide, the malt paste that meet quality criteria requirements
Essence, magnesium stearate and silica, check outer packing, after passed examination, remove outer packing, spare；
(2) it weighs：By polyphyll petal of red rose powder, hydrolyzed pearl powder, ovalbumin peptide, maltodextrin, magnesium stearate and two
Silica weighs in parts by weight respectively, spare；
(3) it mixes：Above-mentioned load weighted component is placed in hopper mixing machine HLD-800, mixes 20~40 minutes, obtains always
Mixed powder；
(4) capsule is filled：By total mixed powder with fully-automatic capsule filling machine NJP-3500B load capsule, 1800~
2500r/min, adjustment loading amount are 0.5g/, and the disintegration time of capsule is 40~60min；
(5) it polishes：Capsule after filling NFJ-150 types polishing machine is polished, temperature during polishing is 18~26 DEG C, wet
Spend is 45%~65%；
(6) inner packing：Bottling packing or aluminium foil plastic sealing pack are carried out to the capsule after polishing；Bottling packing for 100/
Bottle；Aluminium foil plastic sealing pack is 12/plate；
(7) outer packing, inspection, storage：Outer packing is carried out to the capsule after bottling packing or aluminium foil plastic sealing pack, is examined
After qualification, warehousing finished products.
The requirement of production environment sanitary cleaning grade：Production environment and management meet GMP requirements, weigh, mix in production process,
The technical process such as filling capsule, polishing, packing are in the production clean area condition for meeting GB17405-1998 requirements (100,000 grades)
Lower operation；Other steps are operated in general production district.
The beneficial effects of the invention are as follows：A kind of claimed spot-eliminating beauty treatment capsule with healthcare function, respectively
Component is the food of natural food and integration of drinking and medicinal herbs, which uses as health food, and there is soothing liver-qi stagnation, soothing the liver to pacify
God, functions of removing chloasma, beautifying face and moistering lotion and other effects, and it is without side-effects；While being eaten as health food, fundamentally solve
The demand that people like to be beautiful.
Specific embodiment
The given examples are served only to explain the present invention below, is not intended to limit the scope of the present invention.
Embodiment 1
A kind of spot-eliminating beauty treatment capsule, in parts by weight, including following component：40 parts of polyphyll petal of red rose powder, hydrolysis are precious
0.5 part of 40 parts of pearl powder, 20 parts of ovalbumin peptide, 1.5 parts of maltodextrin, silica 1 part and magnesium stearate, the specific steps of preparation
It is as follows：
(1) prepare Packing Sound, up-to-standard polyphyll petal of red rose powder, hydrolyzed pearl powder, ovalbumin peptide, malt paste
Essence, magnesium stearate and silica, check outer packing, after passed examination, remove outer packing, spare；
(2) it weighs：By polyphyll petal of red rose powder, hydrolyzed pearl powder, ovalbumin peptide, maltodextrin, magnesium stearate and two
Silica weighs in parts by weight respectively, spare；
(3) it mixes：Above-mentioned load weighted component is placed in hopper mixing machine, 20min is mixed, obtains total mixed powder；
(4) capsule is filled：Total mixed powder fully-automatic capsule filling machine is loaded into capsule, 2200r/min, adjustment dress
Measure is 0.5g/；The disintegration time of capsule is 40min；
(5) it polishes：Capsule after filling is polished with polishing machine, temperature during polishing is 21 DEG C, humidity 55%；
(6) inner packing：Bottling packing is carried out to the capsule after polishing；Bottling packing is 100/bottle.
(7) outer packing, inspection, storage：The capsule of bottling packing is subjected to medicine box packaging, appearance is checked, is examined
After qualification, warehousing finished products；
Step (2)~step (6) operates under the conditions of 100,000 grades of clean areas, and step (1) and step (7) are in general clean area
Operation.
Embodiment 2
A kind of spot-eliminating beauty treatment capsule, in parts by weight, including following component：20 parts of polyphyll petal of red rose powder, hydrolysis are precious
0.5 part of 60 parts of pearl powder, 10 parts of ovalbumin peptide, 1 part of maltodextrin, silica 1 part and magnesium stearate, the specific steps of preparation are such as
Under：
(1) prepare the polyphyll petal of red rose powder, hydrolyzed pearl powder, ovalbumin peptide, the malt paste that meet quality criteria requirements
Essence, magnesium stearate and silica, check outer packing, after passed examination, remove outer packing, spare；
(2) it weighs：By polyphyll petal of red rose powder, hydrolyzed pearl powder, ovalbumin peptide, maltodextrin, magnesium stearate and two
Silica weighs in parts by weight respectively, spare；
(3) it mixes：Above-mentioned load weighted component is placed in hopper mixing machine, 40min is mixed, obtains total mixed powder；
(4) capsule is filled：Total mixed powder fully-automatic capsule filling machine is loaded into capsule, 1800r/min, adjustment dress
Measure is 0.5g/；The disintegration time of capsule is 50min；
(5) it polishes：Capsule after filling is polished with polishing machine, temperature during polishing is 18 DEG C, humidity 45%；
(6) inner packing：Aluminium foil plastic sealing pack is carried out to the capsule after polishing；Aluminium foil plastic sealing pack is 12/plate；
(7) outer packing, inspection, storage：Capsule after aluminium foil plastic sealing pack is subjected to medicine box packaging with 2 plates/box, to appearance
It is checked, after the assay was approved, warehousing finished products.
Step (2)~step (6) operates under the conditions of 100,000 grades of clean areas, and step (1) and step (7) are in general clean area
Operation.
Embodiment 3
A kind of spot-eliminating beauty treatment capsule, in parts by weight, including following component：60 parts of polyphyll petal of red rose powder, hydrolysis are precious
0.1 part of 20 parts of pearl powder, 15 parts of ovalbumin peptide, 2 parts of maltodextrin, 0.5 part of silica and magnesium stearate, the specific steps of preparation
It is as follows：
(1) prepare the polyphyll petal of red rose powder, hydrolyzed pearl powder, ovalbumin peptide, the malt paste that meet quality criteria requirements
Essence, magnesium stearate and silica, check outer packing, after passed examination, remove outer packing, spare；
(2) it weighs：By polyphyll petal of red rose powder, hydrolyzed pearl powder, ovalbumin peptide, maltodextrin, magnesium stearate and two
Silica weighs in parts by weight respectively, spare；
(3) it mixes：Above-mentioned load weighted component is placed in hopper mixing machine, 30min is mixed, obtains total mixed powder；
(4) capsule is filled：Total mixed powder fully-automatic capsule filling machine is loaded into capsule, 2500r/min, adjustment dress
Measure is 0.5g/；The disintegration time of capsule is 60min；
(5) it polishes：Capsule after filling is polished with polishing machine, temperature during polishing is 26 DEG C, humidity 65%；
(6) inner packing：Aluminium foil plastic sealing pack is carried out to the capsule after polishing；Aluminium foil plastic sealing pack is 6/plate；
(7) outer packing, inspection, storage：Capsule after aluminium foil plastic sealing pack is subjected to medicine box packaging with 1 plate/box, to appearance
It is checked, after the assay was approved, warehousing finished products.
Step (2)~step (6) operates under the conditions of 100,000 grades of clean areas, and step (1) and step (7) are in general clean area
Operation.
Comparative example 1
A kind of spot-eliminating beauty treatment capsule, in parts by weight, including following component：40 parts of polyphyll petal of red rose powder, albumin
0.5 part of 20 parts of peptide, 1.5 parts of maltodextrin, silica 1 part and magnesium stearate, preparation is as follows：
(1) prepare the polyphyll petal of red rose powder, ovalbumin peptide, maltodextrin, the magnesium stearate that meet quality criteria requirements
And silica, it checks outer packing, after passed examination, removes outer packing, it is spare；
(2) it weighs：Polyphyll petal of red rose powder, ovalbumin peptide, maltodextrin, magnesium stearate and silica are pressed respectively
Parts by weight weigh, spare；
(3) it mixes：Above-mentioned load weighted component is placed in hopper mixing machine, 15min is mixed, obtains total mixed powder；
(4) capsule is filled：Total mixed powder fully-automatic capsule filling machine is loaded into capsule, 1500r/min, adjustment dress
Measure is 0.5g/；
(5) it polishes：Capsule after filling is polished with polishing machine, temperature during polishing is 15 DEG C, humidity 40%；Capsule
Disintegration time be 70min；
(6) inner packing：Bottling packing is carried out to the capsule after polishing；Bottling packing is 100/bottle；
(7) outer packing, inspection, storage：Medicine box packaging is carried out to the capsule after bottling packing, checks appearance, it is qualified to examine
Afterwards, warehousing finished products.
Step (2)~step (6) operates under the conditions of 100,000 grades of clean areas, and step (1) and step (7) are in general clean area
Operation.
Comparative example 2
A kind of spot-eliminating beauty treatment capsule, in parts by weight, including following component：40 parts of hydrolyzed pearl powder, 20 parts of ovalbumin peptide,
0.5 part of 1.5 parts of maltodextrin, silica 1 part and magnesium stearate, preparation is as follows：
(1) prepare the hydrolyzed pearl powder, ovalbumin peptide, maltodextrin, magnesium stearate and the dioxy that meet quality criteria requirements
SiClx checks outer packing, after passed examination, removes outer packing, spare；
(2) it weighs：By hydrolyzed pearl powder, ovalbumin peptide, maltodextrin, magnesium stearate and silica respectively by weight
Number weighs, spare；
(3) it mixes：Above-mentioned load weighted component is placed in hopper mixing machine, 10min is mixed, obtains total mixed powder；
(4) capsule is filled：Total mixed powder fully-automatic capsule filling machine is loaded into capsule, 1200r/min, adjustment dress
Measure is 0.5g/；
(5) it polishes：Capsule after filling is polished with polishing machine, temperature during polishing is 20 DEG C, humidity 58%；Capsule
Disintegration time be 75min；
(6) inner packing：Aluminium foil plastic sealing pack is carried out to the capsule after polishing；Aluminium foil plastic sealing pack is 12/plate.
(7) outer packing, inspection, storage：Capsule after aluminium foil plastic sealing pack is subjected to medicine box packaging, checks appearance, is examined
After qualification, warehousing finished products.
Step (2)~step (6) operates under the conditions of 100,000 grades of clean areas, and step (1) and step (7) are in general clean area
Operation.
Comparative example 3
A kind of spot-eliminating beauty treatment capsule, in parts by weight, including following component：40 parts of polyphyll petal of red rose powder, hydrolysis are precious
0.5 part of 40 parts of pearl powder, 1.5 parts of maltodextrin, silica 1 part and magnesium stearate, preparation is as follows：
(1) prepare the polyphyll petal of red rose powder, hydrolyzed pearl powder, maltodextrin, the stearic acid that meet quality criteria requirements
Magnesium and silica check outer packing, after passed examination, remove outer packing, spare；
(2) it weighs：Polyphyll petal of red rose powder, hydrolyzed pearl powder, maltodextrin, magnesium stearate and silica are distinguished
It weighs in parts by weight, it is spare；
(3) it mixes：Above-mentioned load weighted component is placed in hopper mixing machine, 35min is mixed, obtains total mixed powder；
(4) capsule is filled：Total mixed powder fully-automatic capsule filling machine is loaded into capsule, 3000r/min, adjustment dress
Measure is 0.5g/；
(5) it polishes：Capsule after filling is polished with polishing machine, temperature during polishing is 30 DEG C, humidity 70%；Capsule
Disintegration time be 80min；
(6) inner packing：Aluminium foil plastic sealing pack is carried out to the capsule after polishing；Aluminium foil plastic sealing pack is 12/plate.
(7) outer packing, inspection, storage：Capsule after aluminium foil plastic sealing pack is subjected to medicine box packaging, checks appearance, is examined
After qualification, warehousing finished products.
Step (2)~step (6) operates under the conditions of 100,000 grades of clean areas, and step (1) and step (7) are in general clean area
Operation.
Effect example：
Spot-eliminating beauty treatment capsule obtained by embodiment 1-3 and comparative example 1-3 is configured to a concentration of matter respectively with dimethyl sulfoxide (DMSO)
The active ingredient solution than 1% is measured, carries out following experiment.
1. inhibit tyrosine vitality test in mouse melanin cell
B16 mouse melanins cell (Chinese Academy of Sciences's cell bank) in exponential phase is inoculated in 96 orifice plates, is cultivated
Base is the calf serum of RPMI1640+ percents by volume 10%, per 100 μ l (10 of hole4A cell/well), be placed in 37 DEG C, 5%
CO2After being cultivated for 24 hours in incubator, the 50 μ l of active ingredient solution after filtration sterilization are added.Continue after cultivating 3d, discard supernatant
Liquid is rinsed twice with 0.15% (w/v) poly butylene succinate that pH value is 6.8,90 μ l is added to contain 1% (volume fraction) per hole
The PBS (pH value 7.4) of TritonX-100.Ultrasonication in ice bath adds the L-3,4 dihydroxyphenylalanine of 10 μ l 10mmol/L, 37 DEG C of incubations per hole
Each hole absorbance value is surveyed in 60min, the colorimetric at 475nm, blank well zeroing.
Inhibiting rate=(1- medicine groups mean absorbance values+control group mean absorbance values) × 100%
Inhibit tyrosine vitality test result in mouse melanin cell as follows：
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| Inhibiting rate (%) | 64.5 | 60.2 | 62.4 | 50.3 | 55.6 | 53.2 |
2. B16 cell in mouse melanin cell is inhibited to test
By B16 mouse black-in tumor cells with 1 × 105The density of a/ml is inoculated in the culture dish of a diameter of 9cm, 37 DEG C,
5%CO2Under conditions of cultivate 2 days, abandon supernatant, add in the active ingredient solution 18-22ml after filtration sterilization, be then incubated for 3
My god, supernatant is abandoned, PBS washings add in the trypsin solution vitellophag 3min of 0.5ml mass percents 0.2% per hole, add per ware
2ml maintaining liquids terminate digestion.After blowing and beating mixing, each concentration takes out 0.5ml and does cell count.Remaining cell suspension is with 2500r/
Min centrifuges 5min, abandons supernatant, and NaOH solution is added in precipitation, and heating dissolves melanin, under 490nm wavelength conditions,
Using enzyme-linked immunosorbent assay instrument, absorbance value is measured.
B16 cell inhibiting rate=[1- (drug hole absorbance value+drug hole cell density)+(control wells absorbance value+
Control wells cell density)] × 100%.
Inhibit B16 cell result of the test in mouse melanin cell as follows：
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 | |
| Inhibiting rate (%) | 69.8 | 66.5 | 66.8 | 54.8 | 61.6 | 59.9 |
It is above-mentioned the experimental results showed that, spot-eliminating beauty treatment capsule of the invention can effectively inhibit tyrosinase activity, inhibit black
Element generation, spot-eliminating beauty treatment significant effect.And polyphyll petal of red rose powder is not added in, and hydrolyzed pearl powder, nti-freckle U.S. of ovalbumin peptide
Hold the spot-eliminating beauty treatment effect of capsule obviously not as good as the spot-eliminating beauty treatment capsule of the present invention, cooperate the effect of three kinds of components superposition,
Make the spot-eliminating beauty treatment capsule freckle effect of the present invention more preferably.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all the present invention spirit and
Within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Claims (9)
1. a kind of spot-eliminating beauty treatment capsule, which is characterized in that in parts by weight, including following component：Polyphyll petal of red rose powder 20
~60 parts, 20~60 parts of hydrolyzed pearl powder, 10~20 parts of ovalbumin peptide, 2~4 parts of auxiliary material.
2. a kind of spot-eliminating beauty treatment capsule according to claim 1, which is characterized in that in parts by weight, including following component：
40 parts of polyphyll petal of red rose powder, 40 parts of hydrolyzed pearl powder, 20 parts of ovalbumin peptide, 3 parts of auxiliary material.
3. a kind of spot-eliminating beauty treatment capsule according to claim 1 or 2, which is characterized in that in parts by weight, the accessory package
Include 0.5~1 part of 1~2 part of maltodextrin, 0.5~1 part of silica and magnesium stearate.
4. a kind of spot-eliminating beauty treatment capsule according to claim 3, which is characterized in that in parts by weight, the auxiliary material includes
0.5 part of 1.5 parts of maltodextrin, silica 1 part and magnesium stearate.
5. according to a kind of preparation method of spot-eliminating beauty treatment capsule of claim 1-4 any one of them, which is characterized in that specific step
It is rapid as follows：
(1) it weighs：By polyphyll petal of red rose powder, hydrolyzed pearl powder, ovalbumin peptide, maltodextrin, magnesium stearate and titanium dioxide
Silicon weighs in parts by weight respectively, spare；
(2) it mixes：Above-mentioned load weighted component is placed in hopper mixing machine, is sufficiently mixed uniformly, obtains total mixed powder；
(3) capsule is filled：Total mixed powder is loaded into capsule, adjusts loading amount；
(4) it polishes：Capsule after filling is polished；The disintegration time of capsule is 40~60min；
(5) inner packing：Bottling packing or aluminium foil plastic sealing pack are carried out to the capsule after polishing；
(6) outer packing, inspection, storage：Outer packing is carried out to the capsule after bottling packing or aluminium foil plastic sealing pack, it is qualified to examine
Afterwards, warehousing finished products.
6. a kind of preparation method of spot-eliminating beauty treatment capsule according to claim 3, which is characterized in that the step (1)~
Step (5) operates under the conditions of 100,000 grades of clean areas, and step (7) is operated in general clean area.
7. the preparation method of a kind of spot-eliminating beauty treatment capsule according to claim 3, which is characterized in that step (3) is described to fill out
It fills capsule and capsule is loaded using fully-automatic capsule filling machine.
A kind of 8. preparation method of spot-eliminating beauty treatment capsule according to claim 3, which is characterized in that step (4) described throwing
Gloss polishes capsule with polishing machine, and temperature during polishing is 18~26 DEG C, and humidity is 45%~65%.
A kind of 9. preparation method of spot-eliminating beauty treatment capsule according to claim 3, which is characterized in that step (5) described dress
Bottle is packaged as 100/bottle；The aluminium foil plastic sealing pack is 12/plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810001610.1A CN108157949A (en) | 2018-01-02 | 2018-01-02 | A kind of spot-eliminating beauty treatment capsule and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810001610.1A CN108157949A (en) | 2018-01-02 | 2018-01-02 | A kind of spot-eliminating beauty treatment capsule and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108157949A true CN108157949A (en) | 2018-06-15 |
Family
ID=62517028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810001610.1A Pending CN108157949A (en) | 2018-01-02 | 2018-01-02 | A kind of spot-eliminating beauty treatment capsule and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108157949A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109527586A (en) * | 2019-01-03 | 2019-03-29 | 拓普河北生物科技有限公司 | A kind of preparation method of compound micromolecular collagen peptide powder |
| CN111838587A (en) * | 2020-09-01 | 2020-10-30 | 上海培勇生物科技有限公司 | A composition for improving sleep and removing speckle, and its preparation method |
| CN113750221A (en) * | 2020-06-03 | 2021-12-07 | 上海培勇生物科技有限公司 | Composition for improving sleep and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1218690A (en) * | 1997-12-05 | 1999-06-09 | 上海众联生化技术开发有限公司 | Polypeptide oral liquor |
| CN101040710A (en) * | 2007-04-19 | 2007-09-26 | 赵德润 | Health-care nutritious medicinal granules which can be took orally for controlling the incretion for women and can also be used on the skin for beauty |
| CN102342904A (en) * | 2011-10-09 | 2012-02-08 | 湖南今珠生物科技有限公司 | Preparation method for soluble pearl powder |
| CN102885309A (en) * | 2012-10-19 | 2013-01-23 | 中科乐仁（北京）科技发展有限公司 | Chloasma removing healthcare food composite and preparation method thereof |
| CN103142725A (en) * | 2013-04-08 | 2013-06-12 | 湖南今珠生物科技有限公司 | Health care agent with pearl powder, rose and radix salviae miltiorrhizae |
| CN103229883A (en) * | 2013-05-21 | 2013-08-07 | 广东嘉豪食品股份有限公司 | Method for manufacturing rose honey-containing collagen polypeptide tea |
-
2018
- 2018-01-02 CN CN201810001610.1A patent/CN108157949A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1218690A (en) * | 1997-12-05 | 1999-06-09 | 上海众联生化技术开发有限公司 | Polypeptide oral liquor |
| CN101040710A (en) * | 2007-04-19 | 2007-09-26 | 赵德润 | Health-care nutritious medicinal granules which can be took orally for controlling the incretion for women and can also be used on the skin for beauty |
| CN102342904A (en) * | 2011-10-09 | 2012-02-08 | 湖南今珠生物科技有限公司 | Preparation method for soluble pearl powder |
| CN102885309A (en) * | 2012-10-19 | 2013-01-23 | 中科乐仁（北京）科技发展有限公司 | Chloasma removing healthcare food composite and preparation method thereof |
| CN103142725A (en) * | 2013-04-08 | 2013-06-12 | 湖南今珠生物科技有限公司 | Health care agent with pearl powder, rose and radix salviae miltiorrhizae |
| CN103229883A (en) * | 2013-05-21 | 2013-08-07 | 广东嘉豪食品股份有限公司 | Method for manufacturing rose honey-containing collagen polypeptide tea |
Non-Patent Citations (1)
| Title |
|---|
| 范青生: "《保健食品注册申报实用指南》", 31 May 2006, 中国轻工业出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109527586A (en) * | 2019-01-03 | 2019-03-29 | 拓普河北生物科技有限公司 | A kind of preparation method of compound micromolecular collagen peptide powder |
| CN113750221A (en) * | 2020-06-03 | 2021-12-07 | 上海培勇生物科技有限公司 | Composition for improving sleep and preparation method thereof |
| CN111838587A (en) * | 2020-09-01 | 2020-10-30 | 上海培勇生物科技有限公司 | A composition for improving sleep and removing speckle, and its preparation method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100459970C (en) | Skin whitening composition having synergic whitening effect | |
| CN108157949A (en) | A kind of spot-eliminating beauty treatment capsule and preparation method thereof | |
| CN101773464A (en) | Nano whitening anti-wrinkle speckle-removing blain-removing formula and production method thereof | |
| CN101773463A (en) | Selenium-enriched nano pearl powder formula and production method thereof | |
| CN105168106B (en) | One kind three spends whitening and softening skin facial mask liquid and preparation method thereof | |
| CN108434443A (en) | A kind of whitening antioxidation composition and application thereof | |
| CN107927243A (en) | A kind of oil tea leaf beverage of natural anti-aging and preparation method thereof | |
| CN105919906A (en) | Beauty and health care composition | |
| KR20090111719A (en) | Cosmetic Compositions for whitening Skin containing jujube culture | |
| CN114259553B (en) | Enzyme medicine or cosmetic | |
| CN108348563A (en) | Contain composition for prevent, improve or treat peripheral neuropathy of the Asian puccoon root extract as active ingredient | |
| CN100396303C (en) | Deer fetus-pearl capsule | |
| CN101537081B (en) | Matsutake health-care medicinal liquor with anticancer function and human body immunizing power enhancement function | |
| CN108434338A (en) | Using anticancer herbal drug as the righting qi-restoratives Chinese medicine preparation of raw material | |
| CN104173607B (en) | It is a kind of to treat pharmaceutical composition of chloasma and preparation method thereof | |
| CN104473834A (en) | Application of ant extract as effective component in preparation of cosmetics | |
| CN102048815B (en) | Traditional Chinese medicine composition and preparation with whitening and anti-speck efficacies, as well as preparation method thereof | |
| CN109125189A (en) | A kind of inclusion enclave Essence and preparation method thereof of the instant bright color of energy | |
| CN113893197A (en) | Skin whitening and anti-saccharification soluble beautifying microneedle patch composition and preparation method thereof | |
| CN107375012A (en) | A kind of skin barrier remediation composition and preparation | |
| JP7281801B2 (en) | Epidermal stem cell differentiation promoter | |
| CN107224417A (en) | Chlorella facial mask and its preparation method and application | |
| CN102423353A (en) | Chinese medicinal composition with whitening effect | |
| CN112869159A (en) | Anti-wrinkle health product containing folic acid | |
| KR20210064441A (en) | A freckle beauty formula |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Address after: 200000 Shanghai Jiading District silver Xiang Road 655 1 Building 3 story 313 room Y05 Applicant after: Shanghai Pei Yong Biological Technology Co., Ltd. Address before: 200000 Changyang Road, Yangpu District, Shanghai, room 501-1, room 2588 Applicant before: Shanghai Pei Yong Biological Technology Co., Ltd. |
|
| CB02 | Change of applicant information | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180615 |
|
| RJ01 | Rejection of invention patent application after publication |