CN108434338A - Using anticancer herbal drug as the righting qi-restoratives Chinese medicine preparation of raw material - Google Patents

Abstract

The invention belongs to health products preparation fields, and in particular to a kind of using anticancer herbal drug as the righting qi-restoratives Chinese medicine preparation of raw material.Include the raw material of following parts by weight, 20 25 parts of ganoderma lucidum mycelium, 57 parts of oldenlandia diffusa, 15 20 parts of cassia twig, 48 parts of the fruit of glossy privet, 6 10 parts of the fruit of Chinese wolfberry, 69 parts of Radix Ophiopogonis, 5 10 parts of Schisandra chinensis, 35 parts of lily, 56 parts of the stem of noble dendrobium, 35 parts of radix polygonati officinalis.Invention formulation adopting both clearing heat method and tonification method, fever and chills are simultaneously adjusted, and are very suitable for weak cancer patient and are taken after surgery or after chemicotherapy, righting qi-restoratives significant effect.

Description

Using anticancer herbal drug as the righting qi-restoratives Chinese medicine preparation of raw material

Technical field

The invention belongs to health products preparation fields, and in particular to a kind of using anticancer herbal drug as the righting qi-restoratives Chinese medicine of raw material Preparation.

Background technology

With the development and progress of medical technology, after treatment, survival period gradually extends cancer patient.But cancer patient one As will be treated surgically and subsequent chemicotherapy, after operative treatment, patient generally will appear deficiency of vial QI.After adding Continuous chemicotherapy, generally cause entire patient discomfort, dizzy, dizzy, lassitude, weak, anorexia, Nausea and vomiting, Neuroleptic Leukocytopenia and alopecia etc..

When deficiency of vial QI occurs in tumor patient, preferably treated with qi-restoratives medicine or with qi-restoratives medicine cooperation eliminating evil medicine with controlling, to hold under the arm just Eliminating evil.The righting qi-restoratives medicine overwhelming majority is reacted without overt toxicity and adverse reaction, many drugs can also prevent chemotherapy, radiotherapy not Good reaction, such as Neuroleptic Leukocytopenia can promote the recovery of body after operation.It is clinical often with other class anticancer herbal drugs, chemotherapy, put Treatment, operation etc. are used cooperatively.

But for tumor patient, constitution itself is very weak, thus be suitable only for not taking coldly it is not hot, oiliness not Dry, very steady prescription, can realize that adopting both clearing heat method and tonification method, fever and chills are simultaneously adjusted.

Invention content

In view of the above-mentioned deficiencies in the prior art, it is an object of the present invention to provide a kind of using anticancer herbal drug as the righting of raw material benefit Empty Chinese medicine preparation.Said preparation adopting both clearing heat method and tonification method, fever and chills are simultaneously adjusted, and are very suitable for weak cancer patient and are taken after surgery or after chemicotherapy With righting qi-restoratives significant effect.

To achieve the purpose of the present invention, it adopts the following technical scheme that：

It is a kind of using anticancer herbal drug as the righting qi-restoratives Chinese medicine preparation of raw material, include the raw material of following parts by weight, ganoderma lucidum mycelium 20-25 parts, 5-7 parts of oldenlandia diffusa, 15-20 parts of cassia twig, 4-8 parts of the fruit of glossy privet, 6-10 parts of the fruit of Chinese wolfberry, Radix Ophiopogonis 6-9 part, Schisandra chinensis 5-10 parts, 3-5 parts of lily, 5-6 parts of the stem of noble dendrobium, 3-5 parts of radix polygonati officinalis.

Preferably, described using anticancer herbal drug as the righting qi-restoratives Chinese medicine preparation of raw material, include the original of following parts by weight Material, 23 parts of ganoderma lucidum mycelium, 6 parts of oldenlandia diffusa, 18 parts of cassia twig, 6 parts of the fruit of glossy privet, 8 parts of the fruit of Chinese wolfberry, 7 parts of Radix Ophiopogonis, Schisandra chinensis 8 Part, 4 parts of lily, 6 parts of the stem of noble dendrobium, 4 parts of radix polygonati officinalis.

The cultural method of the ganoderma lucidum mycelium includes the following steps：

1）It counts in parts by weight, 10-15 parts of solanum lyratum, 8-12 parts of gynostemma pentaphylla, 10-15 parts of white fungus, 4-6 parts of longan, peanut red coat 2-3 parts, 5-6 parts of Radix Glycyrrhizae, 20-25 parts of glucose, 5-10 parts of agar powder, 800-850 parts of sterile water；By formula weigh solanum lyratum, Gynostemma pentaphylla, white fungus, longan, peanut red coat and Radix Glycyrrhizae dry product, crush, be dissolved in sterile water and boiling, add glucose and fine jade Cosmetics, stirring adjust pH value to 5.5-6.5, are sub-packed in 500mL triangular flasks, silica gel plug sealing；Using high-pressure steam sterilizing pan Sterilization, sterilizes 30-40 minutes by 130 DEG C；Taking-up is sub-packed in the culture dish of diameter 6cm, loading amount 20mL, waits for that matrix is solidifying It is inoculated with after Gu；

2）Inoculation, culture：Each culture dish accesses lucidum strain, inoculum concentration 1-5wt%, and inoculation is placed on 28-30 DEG C of incubator Middle light culture waits for that Ganoderma lucidum mycelium is covered with stromal surface, Ganoderma lucidum mycelium is collected, and crushes, dry, obtains ganoderma lucidum mycelium.

Each raw material effect is as follows：

Cassia twig, nature and flavor acrid, sweet, warm enter lung, the heart, bladder warp, are to cure mainly the common drugs for dispelling internal cold of interior cold, have complement sun, logical blood The effect of arteries and veins, warming spleen and stomach, has the function of significantly analgesia and anti-cancer and cancer-preventing.

The fruit of glossy privet, alias glossy privet reality, purpleflower holly fruit, wax tree, mouse Chinese catalpa, are the dry mature fruit of Oleaceae plants glossy privet, Kidney tonifying enriching yin simply, the Chinese medicine to nourish the liver to improve visual acuity, in clinic be suitable for kinds of tumors, as liver cancer, various middle and advanced stage arsine tumors and After tumor patient radiation and chemotherapy.

Oldenlandia diffusa, it is patent medicine bitter, light, it is cold in nature.Primary efficacy is clearing heat and detoxicating, medicinal powder for relieving pain knot, promoting urination and removing dampness.In vain Flower HERBA HEDYOTIS DIFFUSAE has inhibition to make in leukaemia cell such as acute myeloblastic leukemia cell, acute lymphatic leukemia cell in vivo With.

The fruit of Chinese wolfberry be rich in polysaccharides, polysaccharides is a kind of water-soluble polysaccharide, by arabinose, glucose, galactolipin, This 6 kinds of monosaccharide components compositions of mannose, xylose, rhamnose, have physiological activity, can enhance non-specific immune function, carry High disease resistance inhibits tumour growth and cell mutation.

Radix Ophiopogonis is sweet in flavor, slight bitter, is slightly cold.Moistening lung clears away heart-fire, have it is antifatigue, remove free radical, improve cellular immune function with And hypoglycemic effect.

Schisandra chinensis is astringed the lung, and nourshing kidney is promoted the production of body fluid.

Lily, sweet and slightly bitter taste is mild-natured, enters cardiopulmonary warp；With moisten the lung and relieve the cough, yin-nourishing disappear heat, clearing away the heart fire and tranquillizing the benefits of.

The stem of noble dendrobium, meridian distribution of property and flavor are slightly cold, sweet, return stomach, kidney channel.

Radix polygonati officinalis is mended and oiliness, not cold not dry, thus have " clearing heat and moistening lung, yin-nourishing relieve dizziness, high fever, infantile convulsions, epilepsy, etc., help the five internal organs, nourish qi and blood, put down mend and The effect of profit, and remove wind-heat ", act on taste, therefore the long term usage not impairment of the spleen.

Ganoderma lucidum mycelium has invigorating qi for tranquilization, relieving cough and asthma effect, to mouse S180 inhibiting rates up to 87.6%, ingredient Containing polysaccharide and protein, antitumor action is notable.

Ganoderma lucidum can be soaked or brews up, but taste is bitter, and common people cannot receive；Although resistance can be enhanced Power, but effect is but less apparent.Ganoderma lucidum and related Chinese medicine are used in compounding, because Chinese medicine compounding is more complicated engineering, It is related to monarch combination principle, therefore it is also a problem to prepare a kind of significant Chinese medicine composition of drug effect.

The present invention has the following advantages compared with the prior art：

1）The present invention using solanum lyratum, gynostemma pentaphylla, white fungus, longan, peanut red coat, Radix Glycyrrhizae as the main component of Medium for Ganoderma lucidum, For cultivating ganoderma lucidum mycelium.On the one hand nutritional ingredient in Chinese medicine can provide necessary nutrient for ganoderma lucidum grown cultures Deng, on the other hand these nutritional ingredients can be absorbed by ganoderma lucidum, in ganoderma lucidum mycelium growth course, the active constituent hair with ganoderma lucidum Raw bioconversion, culture obtain the ganoderma lucidum mycelium that a variety of drug effects are integrated in one；

2）For this composition based on cassia twig, ganoderma lucidum mycelium, anti-cancer and cancer-preventing effect is notable.Cassia twig is walked without keeping, with Ganoderma lucidum mycelium Body, the fruit of Chinese wolfberry share, and warm yang transforming qi, blood circulation-promoting functions are fine, and can enhance hematopoiesis function；Simultaneously in order to restrict cassia twig it is hot it Property, dry strong property select the stem of noble dendrobium, radix polygonati officinalis, lily, Schisandra chinensis, Radix Ophiopogonis, fruit of glossy privet Six-element medicine to carry out heat-clearing enriching yin first, wherein radix polygonati officinalis, Part of the body cavity above the diaphragm housing the heart and lungs lung-fire drops in lily, Radix Ophiopogonis, the fire of burnt liver stomach in stem of noble dendrobium drop, and Schisandra chinensis, fruit of glossy privet drop kidney of lower warmer are fought enriching yin.Oldenlandia Grass and the fruit of Chinese wolfberry are arranged in pairs or groups mutually, the warm nature of the fruit of Chinese wolfberry and the cold mutual restriction of oldenlandia diffusa.This prescription adopting both clearing heat method and tonification method is trembled with fear Heat is simultaneously adjusted, and is very suitable for weak cancer patient and is taken after surgery or after chemicotherapy, righting qi-restoratives significant effect.

Specific implementation mode

Further to disclose rather than the present invention is limited, the present invention is described in further detail below in conjunction with example.

Embodiment 1

It is a kind of using anticancer herbal drug as the righting qi-restoratives Chinese medicine preparation of raw material, include the raw material of following parts by weight, ganoderma lucidum mycelium 20 parts, 7 parts of oldenlandia diffusa, 15 parts of cassia twig, 8 parts of the fruit of glossy privet, 6 parts of the fruit of Chinese wolfberry, 9 parts of Radix Ophiopogonis, 5 parts of Schisandra chinensis, 5 parts of lily, stone 5 parts of dry measure used in former times, 5 parts of radix polygonati officinalis.

The cultural method of the ganoderma lucidum mycelium includes the following steps：

1）It counts in parts by weight, 10 parts of solanum lyratum, 12 parts of gynostemma pentaphylla, 10 parts of white fungus, 6 parts of longan, 2 parts of peanut red coat, Radix Glycyrrhizae 6 Part, 20 parts of glucose, 10 parts of agar powder, 800 parts of sterile water；It is red that solanum lyratum, gynostemma pentaphylla, white fungus, longan, peanut are weighed by formula The dry product of clothing and Radix Glycyrrhizae crushes, is dissolved in sterile water and boiling, add glucose and agar powder, stirs, adjusting pH value to 6.0, It is sub-packed in 500mL triangular flasks, silica gel plug sealing；Using high-pressure steam sterilizing pan sterilization, 130 DEG C, sterilize 35 minutes；It takes In the culture dish for going out to be sub-packed in diameter 6cm, loading amount 20mL is inoculated with after matrix set；

2）Inoculation, culture：Each culture dish accesses lucidum strain, inoculum concentration 1wt%, and inoculation is placed in 29 DEG C of incubators dark Culture, waits for that Ganoderma lucidum mycelium is covered with stromal surface, Ganoderma lucidum mycelium is collected, and crushes, dry, obtains ganoderma lucidum mycelium.

Embodiment 2

It is a kind of using anticancer herbal drug as the righting qi-restoratives Chinese medicine preparation of raw material, include the raw material of following parts by weight, ganoderma lucidum mycelium 23 parts, 6 parts of oldenlandia diffusa, 18 parts of cassia twig, 6 parts of the fruit of glossy privet, 8 parts of the fruit of Chinese wolfberry, 7 parts of Radix Ophiopogonis, 8 parts of Schisandra chinensis, 4 parts of lily, stone 6 parts of dry measure used in former times, 4 parts of radix polygonati officinalis.

The cultural method of the ganoderma lucidum mycelium includes the following steps：

1）It counts in parts by weight, 12 parts of solanum lyratum, 10 parts of gynostemma pentaphylla, 12 parts of white fungus, 5 parts of longan, 3 parts of peanut red coat, Radix Glycyrrhizae 5 Part, 22 parts of glucose, 8 parts of agar powder, 820 parts of sterile water；It is red that solanum lyratum, gynostemma pentaphylla, white fungus, longan, peanut are weighed by formula The dry product of clothing and Radix Glycyrrhizae crushes, is dissolved in sterile water and boiling, add glucose and agar powder, stirs, adjusting pH value to 5.5, It is sub-packed in 500mL triangular flasks, silica gel plug sealing；Using high-pressure steam sterilizing pan sterilization, 130 DEG C, sterilize 35 minutes；It takes In the culture dish for going out to be sub-packed in diameter 6cm, loading amount 20mL is inoculated with after matrix set；

2）Inoculation, culture：Each culture dish accesses lucidum strain, inoculum concentration 5wt%, and inoculation is placed in 28 DEG C of incubators dark Culture, waits for that Ganoderma lucidum mycelium is covered with stromal surface, Ganoderma lucidum mycelium is collected, and crushes, dry, obtains ganoderma lucidum mycelium.

Embodiment 3

It is a kind of using anticancer herbal drug as the righting qi-restoratives Chinese medicine preparation of raw material, include the raw material of following parts by weight, ganoderma lucidum mycelium 25 parts, 5 parts of oldenlandia diffusa, 20 parts of cassia twig, 4 parts of the fruit of glossy privet, 10 parts of the fruit of Chinese wolfberry, 6 parts of Radix Ophiopogonis, 10 parts of Schisandra chinensis, 3 parts of lily, 6 parts of the stem of noble dendrobium, 3 parts of radix polygonati officinalis.

The cultural method of the ganoderma lucidum mycelium includes the following steps：

1）Count in parts by weight, 15 parts of solanum lyratum, 8 parts of gynostemma pentaphylla, 15 parts of white fungus, 4 parts of longan, 3 parts of peanut red coat, 5 parts of Radix Glycyrrhizae, 25 parts of glucose, 5 parts of agar powder, 850 parts of sterile water；By formula weigh solanum lyratum, gynostemma pentaphylla, white fungus, longan, peanut red coat and The dry product of Radix Glycyrrhizae crushes, is dissolved in sterile water and boiling, add glucose and agar powder, stirs, and adjusts pH value to 6.5, dispenses In 500mL triangular flasks, silica gel plug sealing；Using high-pressure steam sterilizing pan sterilization, 130 DEG C, sterilize 30 minutes；It takes out and divides In culture dish loaded on diameter 6cm, loading amount 20mL is inoculated with after matrix set；

2）Inoculation, culture：Each culture dish accesses lucidum strain, inoculum concentration 1wt%, and inoculation is placed in 30 DEG C of incubators dark Culture, waits for that Ganoderma lucidum mycelium is covered with stromal surface, Ganoderma lucidum mycelium is collected, and crushes, dry, obtains ganoderma lucidum mycelium.

Comparative example 1

The mycelial culture of Common ganoderma lucidum：

Inoculation, culture：Lucidum strain, inoculum concentration 5wt% are accessed in PDA culture medium, inoculation is placed in 30 DEG C of incubators dark Culture, waits for that Ganoderma lucidum mycelium is covered with stromal surface, takes ganoderma lucidum mycelium, detect its polysaccharide and triterpene content.Meanwhile to embodiment 1- 3 ganoderma lucidum myceliums cultivated also are detected.

1）Measurement of the polysaccharide content

1. the processing of sample：0.3 gram of mycelia powder for taking different embodiment cultures is respectively placed in the volumetric flask of 50ml dryings, Add water about 40ml, 2h is heated in boiling water bath, and shaked frequently, scale is settled to after being cooled to room temperature, by said extracted Liquid centrifuges 10min in the centrifuge of 4000r/min, takes supernatant spare.2. formulation polysaccharide=total reducing sugar-reduced sugar of sample Phenol-sulphate method and DNS methods is respectively adopted in the measurement of total reducing sugar and reduced sugar.

2）The preparation for measuring 1. sample of triterpene content：The hypha powder 0.3g for taking drying is placed in 50ml volumetric flasks and adds water To scale, in ultrasonoscope after ultrasonication 2.5h, 10min is centrifuged in the centrifuge of 4000r/min, takes supernatant standby With.2. the measurement of sample：The measurement of triterpene uses spectrophotometry.

1 polysaccharide of table and triterpene comparision contents wt/%

The foregoing is merely presently preferred embodiments of the present invention, all equivalent changes done according to scope of the present invention patent with repair Decorations should all belong to the covering scope of the present invention.

Claims (3)

1. a kind of using anticancer herbal drug as the righting qi-restoratives Chinese medicine preparation of raw material, it is characterised in that：Include the original of following parts by weight Material, 20-25 parts of ganoderma lucidum mycelium, 5-7 parts of oldenlandia diffusa, 15-20 parts of cassia twig, 4-8 parts of the fruit of glossy privet, 6-10 parts of the fruit of Chinese wolfberry, wheat Winter 6-9 part, 5-10 parts of Schisandra chinensis, 3-5 parts of lily, 5-6 parts of the stem of noble dendrobium, 3-5 parts of radix polygonati officinalis.

2. according to claim 1 using anticancer herbal drug as the righting qi-restoratives Chinese medicine preparation of raw material, it is characterised in that：Including The raw material of following parts by weight, 23 parts of ganoderma lucidum mycelium, 6 parts of oldenlandia diffusa, 18 parts of cassia twig, 6 parts of the fruit of glossy privet, 8 parts of the fruit of Chinese wolfberry, wheat 7 parts of winter, 8 parts of Schisandra chinensis, 4 parts of lily, 6 parts of the stem of noble dendrobium, 4 parts of radix polygonati officinalis.

3. according to claim 1 or 2 using anticancer herbal drug as the righting qi-restoratives Chinese medicine preparation of raw material, it is characterised in that： The cultural method of the ganoderma lucidum mycelium includes the following steps：

1）It counts in parts by weight, 10-15 parts of solanum lyratum, 8-12 parts of gynostemma pentaphylla, 10-15 parts of white fungus, 4-6 parts of longan, peanut red coat 2-3 parts, 5-6 parts of Radix Glycyrrhizae, 20-25 parts of glucose, 5-10 parts of agar powder, 800-850 parts of sterile water；By formula weigh solanum lyratum, Gynostemma pentaphylla, white fungus, longan, peanut red coat and Radix Glycyrrhizae dry product, crush, be dissolved in sterile water and boiling, add glucose and fine jade Cosmetics, stirring adjust pH value to 5.5-6.5, are sub-packed in 500mL triangular flasks, silica gel plug sealing；Using high-pressure steam sterilizing pan Sterilization, sterilizes 30-40 minutes by 130 DEG C；Taking-up is sub-packed in the culture dish of diameter 6cm, loading amount 20mL, waits for that matrix is solidifying It is inoculated with after Gu；

2）Inoculation, culture：Each culture dish accesses lucidum strain, inoculum concentration 1-5wt%, and inoculation is placed on 28-30 DEG C of incubator Middle light culture waits for that Ganoderma lucidum mycelium is covered with stromal surface, Ganoderma lucidum mycelium is collected, and crushes, dry, obtains ganoderma lucidum mycelium.