CN104473834A - Application of ant extract as effective component in preparation of cosmetics - Google Patents
Application of ant extract as effective component in preparation of cosmetics Download PDFInfo
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- CN104473834A CN104473834A CN201410663622.2A CN201410663622A CN104473834A CN 104473834 A CN104473834 A CN 104473834A CN 201410663622 A CN201410663622 A CN 201410663622A CN 104473834 A CN104473834 A CN 104473834A
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Abstract
The invention discloses an application of an ant extract as an effective component in preparation of cosmetics, belonging to the field of daily-use chemical industry. The ant extract disclosed by the invention can be used for inhibiting the proliferation of melanoma cells, and has certain freckle-removing and whitening effects; the ant extract can also be used for protecting the activity of skin flbroblasts, significantly increasing the secretion of collagen and hydroxyproline in the skins and enhancing the skin elasticity, and has a certain anti-aging effect; and meanwhile, the ant extract can be used for improving the activity of superoxide dismutase (SOD) and reducing the production amount of reactive oxygen species (ROS), and has a certain anti-oxidation effect. The ant extract disclosed by the invention has the characteristics of stable biological activity, good water solubility and the like, and can be taken as the effective component of the cosmetics to be applied to freckle-removing and whitening cosmetics, anti-aging cosmetics, anti-oxidant cosmetics or the combination thereof.
Description
Technical field
The present invention relates to a kind of cosmetic actives, being specifically related to Formica fusca extract as effective ingredient preparing the application in cosmetics, belonging to filed of daily-use chemical industry.
Background technology
At present, cosmetics industry in daily life in occupation of considerable status.The daily use chemicals industry development of China is very fast, and new product makes rapid progress, and market presents unprecedented prosperity scene.Much medicinal plant and animal is applied to functional cosmetics successively and produces, and creates good Social and economic benef@.Therefore, the cosmetics containing sp act composition that prepared by application Chinese medicine theory and modern science and technology are more and more paid much attention in daily chemical industry.
Natural drug is long at the applicating history of beauty and skin care, namely occurs as far back as Qin Han dynasty, very prevailing to the Tang Dynasty.The material such as organic acid, oils and fats, alkaloid, tannin, glycoside, quintessence oil, phlegmatic temperament, protein, aminoacid, vitamins, mineral, trace element, phytohormone contained in natural drug all can produce different effect and impact to human body skin.As tannin have convergence skin effect, saponin has decontamination contaminant releasing effect, acid has anti-inflammation and sterilization effect, mucopolysaccharide has moisture-keeping function, aminoacid energy skin nutrition reduce wrinkle produce, protein to enhancing skin elasticity also benefit.Along with the progress of science and technology, numerous active component contained in natural drug can be extracted to be separated, and this also creates condition for natural drug in the application of household chemicals field.
Insecticide worldwide obtains higher accreditation as a kind of novel health product.The nutritive value of United Nations Food and Agriculture Organization to insecticide also gives higher evaluation, thinks that insect protein is 21 century mankind total nutrient health product.Formica fusca is one of the most familiar and modal insecticide of people, and its population quantity is huge, widely distributed.Formica fusca belongs to Arthropoda Insecta wing order Formicidae, and the Formica fusca with use and medical value mainly contains kind more than 10.Wherein, Polyhachis vicina Roger be state food health, unique Formica fusca that there is medicine, eat dual-purpose value of medical approved by management.Confirm through scientific research, Polyhachis vicina Roger have antiinflammatory, relieving asthma, spasmolytic, analgesia, hepatoprotective, skin care and enhancing immune function of human body effect, can be rated as " microfauna nutrition treasure-house " and " natural drug processing factory ".
Ant is treated, namely with functions such as the speciality of the medicine-food two-purpose of Formica fusca, fusion Formica fusca nourishing the human Body, strengthening spleen, tonifying kidney, dredge the meridian passage, benefiting QI for activating blood circulation, skin care, two-ways regulation immunity, antiviral, antiinflammatory, analgesia and calmness, improve body resisting fatigue ability and immunity, play health care's effects such as balanced body nutrition and slow down aging.Also the record about Formica fusca " physical strength profiting, damp color " effect is had in Compendium of Material Medica and supplementary Amplifications of the Compendium of Materia Medica.At present, Formica fusca and important compatibility are often made prescription, for scientific research and disease treatment by Chinese scholar.Formica fusca and preparation thereof have many-sided pharmacological action, and wherein, the anti-aging effects of Formica fusca and beautification function obtain to be paid close attention to comparatively widely.Hamann proposed in 1956, and human body will inevitably produce some free radicals in vital movement, can react, cause damage, cause human senility to body with some composition in body.Lipid peroxide in blood also can increase with the increase at age, and this material is the core substance forming fat brown fat, fat brown fat is deposited in neurocyte and can makes membrane protein matter and lipid generation peroxidization, cause its permeability changes, cell division, afunction, accelerates cell ageing.And the superoxide anion that the deactivation of superoxide dismutase (SOD) energy is too much, protection body exempts from the infringement of superoxide radical.The multiple bioactive ingredients energy resisting fatigue contained in Formica fusca body, physical strength reinforcing, significantly scavenging free radicals, slow down aging, life-saving.Multinomial research shows, Formica fusca Aqueous extracts has the effect of significant resisting fatigue, low temperature resistant, high temperature resistant, anoxia enduring, the superoxide dismutase (SOD) that can significantly improve in aged white mice blood plasma and cerebral tissue is active, reduces the effect of lipid peroxide and Free Radical Level in aged white mice blood plasma and cerebral tissue.In addition, body's immunity declines also is old and feeble major reason.Along with the increase at age, the separating capacity of body to own cells and exogenous cells goes down, and the immunoreation of exogenous cell weakens, the large macrolesion of immunological effect.Formica fusca Aqueous extracts can make the rudimentary thymic hyperplasia of aged white mice, and thymic cortex thickens, and peripheral lymphocyte increases, and obviously promotes aged white mice lymphocytic cell division, increases the content of cell DNA nRNA, immunologically competent cell number is increased.Therefrom medical angle, aging mainly comprises " unbalance " and " deficient " two aspects, be yin and yang imbalance, disorder of QI and blood, so that internal organs void declines, and vital essence can not get moistening foster, finally causes aging.And research shows, Formica fusca energy strengthening the body resistance, nourishing the liver and kidney, tonifying both YIN and YANG, qi and blood tonifying, blood circulation promoting and blood stasis dispelling, appetite promoting and the spleen strengthening.Therefore, Formica fusca has life lengthening, face-beautifying health-care, antidotal effect.Be mainly used in the experimental therapy of immune dysfunction, endocrine regulation and the disease relevant with aging at present clinically.
Modern science is analyzed, and containing 70 multiple nutritional components in Polyhachis vicina Roger body, comes out at the top in its active component content Bai Baiwan kind animal and plant.The composition relevant to the effect of Formica fusca face nourishing antidebilitation mainly comprises:
1, protein: the protein content in Formica fusca accounts for 42-67%.Containing extraordinary insect active high-quality protein in Formica fusca, face can be made after taking white and ruddy, and can brain cell be activated, slow down aging.
2, aminoacid: containing 28 kinds of free amino acids in Formica fusca, comprising necessary 8 seed amino acids of human body, contributes to maintaining body metabolism and energy supply.
3, vitamin and trace element: containing 20 various trace elements such as vitamin B1, B2, B12, C, D, E etc. and calcium, ferrum, phosphorus, manganese, selenium, zinc in Formica fusca.Wherein selenium can antioxidation, removes interior free yl.Zn content in Formica fusca particularly attracts people's attention.Zinc participates in brain cell and grows, and improves immunologic function, promotes that growth in humans grows, slow down aging, is described as " Promethean fire flower " by physician and nutritionist.Research display, zinc also can prevent ophthalmic, wrinkle resistant, enhancing human body immunity power, thus provides reliable material base for kidney and spleen invigorating.
4, triterpenoid compound: triterpenoid compound contained in Formica fusca has the effects such as pain relieving, calmness, suppression histamine release, there is the effects such as significant blood pressure lowering, blood fat reducing and antiallergic, to hypertension, hyperlipidemia, insomnia and various respiratory systemic disease, there is therapeutical effect.
5, adenosine triphosphate: adenosine triphosphate is the coenzyme extensively existed in body, it is the main source of histiocyte institute energy requirement, participate in the metabolic processes such as body fat, protein, sugar, nucleic acid, nucleotide, for the energy that absorption, secretion, muscle contraction and biochemical synthetic reaction of carrying out provide required, have and promote cytothesis and regeneration, strengthen effect of cell metabolic activity.
6, cursive script formaldehyde: cursive script formaldehyde be manually cannot synthesize there is multiple bioactive material.Cursive script formaldehyde energy conditioner body immunity function, endocrine regulation system, enhancing human body immunity power, also has stronger Scavenging activity to virus.
7, interleukin II: interleukin energy enhancing human body immunity function, activation cytokines, containment malignant change of cell and antiviral.
8, chitin: the chitin contained in Formica fusca shell is cation edibility animal fiber unique in the world, has two-way immunoregulation effect, and can remove interior free yl, has desirable health care preventive effect to sub-health state.
9, formic acid: the effect containing formic acid in Formica fusca with powerful benefiting vital QI and blood, all substances found up to now all cannot be compared with it, and this is also the source that Formica fusca can survive so far from Age of Dinosaur for nearly 200,000,000 years.
Formica fusca is as nutrition treasure-house and natural drug processing factory, and the nutritional labeling abundant with it and definite curative effect, be expected to become righting and do not stay heresy, eliminating evil and do not hinder and positive have the desirable cosmetic actives of remarkable freckle removing and whitening, defying age and antioxidative.Formica fusca extract of the present invention has the features such as biological activity is stable, water solublity is good, can be used as cosmetic actives in cosmetics.
Summary of the invention
The object of the present invention is to provide a kind of new purposes of Formica fusca extract, namely Formica fusca extract is preparing the application in cosmetics as effective ingredient.
Wherein, described Formica fusca extract can check melanin tumor cell proliferation, has certain freckle removing and whitening effect; Described Formica fusca extract can protect skin flbroblast vigor, significantly increases the secretion of collagen protein and hydroxyproline in skin, strengthens skin elasticity, has certain anti-aging effects; Described Formica fusca extract can promote superoxide dismutase (SOD) vigor and reduce the generation of active oxygen (ROS), has certain antioxidation.
In the present invention, preferably, described Formica fusca extract is used for check melanin tumor cell proliferation, and the minimal effective concentration playing freckle removing and whitening effect is 10
-4g/mL; Described Formica fusca extract, for the protection of skin flbroblast vigor, significantly increases the secretion of collagen and hydroxyproline in skin, and strengthen skin elasticity, the minimal effective concentration playing anti-aging effects is 10
-4g/mL; Described Formica fusca extract is for promoting superoxide dismutase (SOD) vigor and reducing the generation of active oxygen (ROS), and the minimal effective concentration playing antioxidation is 10
-4g/mL.
In the present invention, preferably, described Formica fusca is Polyhachis vicina Roger (Polyrhachis vicina Roger).
In the present invention, preferably, the preparation method of described Formica fusca extract is:
(1) vacuum freeze drier dry Polyhachis vicina Roger queen is adopted to be pulverized by Polyhachis vicina Roger;
(2) 40% ethanol ultrasonic extraction 15 ~ 90min is adopted;
(3) extracting liquid filtering will obtained, collects filtrate, adopts rotary evaporator concentrate and collect concentrated solution;
(4) adopt vacuum freeze drier that concentrated solution is carried out drying after concentrated solution-80 DEG C of pre-coolings, obtain final extract, be placed in 4 DEG C and save backup.
In the present invention, preferably, described cosmetics are selected from freckle whitening makeup, anti-aging cosmetics, antioxidation cosmetic product or its combination.
In the present invention, preferably, described cosmetic forms is fancy soap, cleansing milk, bath gel, toner/smoothing toner, skin protection gel, facial treatment milk, protective skin cream, essence, eye cream, facial film, aerosol or spraying.
Accompanying drawing explanation
Fig. 1 is inhibitory action figure (*: compared with blank group, the P<0.05 that Formica fusca extract is bred melanoma cell; *: compared with blank group, P<0.01);
Fig. 2 is the protective effect figure (* *: with blank group compared with, P<0.01) of Formica fusca extract to skin flbroblast vigor;
Fig. 3 is the facilitation figure (*: with blank group compared with, P<0.05) of Formica fusca extract to skin flbroblast secretion hydroxyproline;
Fig. 4 is the facilitation figure (*: with blank group compared with, P<0.05) of Formica fusca extract to skin flbroblast secretion collagen;
Fig. 5 is that Formica fusca extract strengthens superoxide dismutase (SOD) vigor action diagram (*: compared with blank group, P<0.05) in skin flbroblast;
Fig. 6 is the action diagram (* *: compared with blank group, P<0.01) that Formica fusca extract reduces that in skin flbroblast, active oxygen (ROS) produces, and wherein, 0g/mL group is blank group.
Detailed description of the invention
Below by experiment, also the present invention will be further described in conjunction with the embodiments, it should be understood that these embodiments only for the object of illustration, never limit the scope of the invention.
The preparation of embodiment 1 Formica fusca extract
Polyhachis vicina Roger, buys from Harbin Pharmaceutical Group's generation prepared slices of Chinese crude drugs Co., Ltd.
Polyhachis vicina Roger first uses vacuum freeze drier dry, pulverize immediately after drying, accurately take 60g Formica fusca powder, add 40% alcoholic solution of Formica fusca powder volume 2 ~ 6 times, be extract under the ul-trasonic irradiation of 30 ~ 50KHZ in frequency, Extracting temperature is 40 ~ 90 DEG C, and extraction time is 15 ~ 90min, obtains extracting solution, the extracting solution obtained is filtered, collect filtrate, concentrate (50rpm, 40 DEG C) by rotary evaporator and collect concentrated solution.Concentrated solution-80 DEG C of pre-coolings 2 hours, put into vacuum freeze drier drying, weighing, obtain final extract, are placed in 4 DEG C and save backup.
The pharmacodynamic study of embodiment 2 Formica fusca extract vitro inhibition melanoma cell propagation
1. human melanoma cell (M14) is placed in 96 orifice plates, adjustment cell concentration is every hole 1 × 10
4, and add 200 μ L culture fluid in every hole, constant temperature 37 DEG C of overnight incubation;
2. Formica fusca extract is dissolved to concentration with culture fluid and is respectively 10
-3g/mL, 10
-4g/mL, 10
-5g/mL, 10
-6g/mL, 10
-7g/mL, and be added in above-mentioned Tissue Culture Plate and cultivate 24h;
3. MTT storing solution is added in above-mentioned cell culture fluid, cultivates 4h in 37 DEG C at dark place;
4. remove culture fluid and after adding a certain amount of DMSO, under room temperature, shake 15min, and measuring the absorption of each sample in 490nm place.
The results are shown in Figure 1, as shown in Figure 1, Formica fusca extract can the propagation of check melanin oncocyte, and this effect is within the specific limits in dose dependent, and Formica fusca extract suppresses the valid density of M14 propagation to be 10
-4g/mL (*: compared with blank group, P<0.05; *: compared with blank group, P<0.01).
The pharmacodynamic study of embodiment 3 Formica fusca extract external protection skin flbroblast vigor
1. human skin fibroblast (HSF) is placed in 96 orifice plates, adjustment cell concentration is every hole 1 × 10
4, and add 200 μ L culture fluid in every hole, constant temperature 37 DEG C of overnight incubation;
2. Formica fusca extract is dissolved to concentration with culture fluid and is respectively 10
-4g/mL, 10
-5g/mL, 10
-6g/mL, and be added in above-mentioned Tissue Culture Plate and cultivate 24h;
3. with H
2o
2process cell 1h, cellular oxidative damage;
4. MTT storing solution is added in above-mentioned cell culture fluid, cultivates 4h in 37 DEG C at dark place;
5. remove culture fluid and after adding a certain amount of DMSO, under room temperature, shake 15min, and measuring the absorption of each sample in 490nm place.
The results are shown in Figure 2, as shown in Figure 2, Formica fusca extract can suppress by H
2o
2the HSF apoptosis of induction, and this protective effect is within the specific limits in dose dependent, the valid density of Formica fusca extract protection HSF cell viability is 10
-5g/mL (* *: compared with blank, P<0.01).
The pharmacodynamic study of hydroxyproline secretion in the external promotion skin flbroblast of embodiment 4 Formica fusca extract
1. human skin fibroblast (HSF) is placed in 6 orifice plates, adjustment cell concentration is every hole 1 × 10
5, and add 2mL culture fluid in every hole, constant temperature 37 DEG C of overnight incubation;
2. Formica fusca extract is dissolved to concentration with culture fluid and is respectively 10
-4g/mL, 10
-5g/mL, and be added in above-mentioned Tissue Culture Plate and cultivate 24h;
3. get each group of cell conditioned medium liquid to detect as testing sample;
4. by hydroxyproline test kit description, the hydroxyproline content in each testing sample is detected (hydroxyproline test kit builds up Bioengineering Research Institute by Nanjing and provides).
The results are shown in Figure 3, as shown in Figure 3, Formica fusca extract can promote the secretion of hydroxyproline in HSF, and Formica fusca extract promotes that the valid density of hydroxyproline secretion is 10
-4g/mL (*: compared with model group, P<0.05).
The pharmacodynamic study of collagen content in the external increase skin flbroblast of embodiment 5 Formica fusca extract
1. human skin fibroblast (HSF) is placed in 6 orifice plates, adjustment cell concentration is every hole 1 × 10
5, and add 2mL culture fluid in every hole, constant temperature 37 DEG C of overnight incubation;
2. Formica fusca extract is dissolved to concentration with culture fluid and is respectively 10
-4g/mL, 10
-5g/mL, and be added in above-mentioned Tissue Culture Plate and cultivate 24h;
3. by cell with after the cracking of RIPA lysate, the centrifugal 5min of 13500rpm, gets supernatant 100 μ L as testing sample;
4. detect ELISA kit description by collagen content to detect (collagen detects ELIS test kit and provided by Uscn Life Science Inc company) the collagen content in each testing sample.
The results are shown in Figure 4, as shown in Figure 4, Formica fusca extract can increase the content of collagen in HSF, and the valid density that Formica fusca extract increases collagen content is 10
-5g/mL (*: compared with blank group, P<0.05; *: compared with blank, P<0.01).
The pharmacodynamic study of superoxide dismutase (SOD) vigor in the external increase skin flbroblast of embodiment 6 Formica fusca extract
1. human skin fibroblast (HSF) is placed in 6 orifice plates, adjustment cell concentration is every hole 1 × 10
5, and add 2mL culture fluid in every hole, constant temperature 37 DEG C of overnight incubation;
2. Formica fusca extract is dissolved to concentration with culture fluid and is respectively 10
-4g/mL, 10
-5g/mL, and be added in above-mentioned Tissue Culture Plate and cultivate 24h;
3. by cell with after the cracking of RIPA lysate, the centrifugal 5min of 13500rpm, gets supernatant 20 μ L as testing sample;
4. by total SOD activity detection kit (WST-8) description, the SOD activity in each testing sample is detected (total SOD activity detection kit (WST-8 method) provided by green skies biotechnology research).
The results are shown in Figure 5, as shown in Figure 5, Formica fusca extract can strengthen the activity of SOD in HSF, and the valid density that Formica fusca extract increases SOD activity is 10
-4g/mL (*: compared with blank group, P<0.05).
The pharmacodynamic study that in the external minimizing skin flbroblast of embodiment 7 Formica fusca extract, active oxygen (ROS) generates
1. human skin fibroblast (HSF) is placed in 25cm
2in culture bottle, adjustment cell concentration is every bottle 1 × 10
6, and add 5mL culture fluid at every bottle, constant temperature 37 DEG C of overnight incubation;
2. Formica fusca extract is dissolved to concentration with culture fluid and is respectively 10
-4g/mL, 10
-5g/mL, and be added in above-mentioned Tissue Culture Flask and cultivate 24h;
3. cell dissociation is become suspended state, the centrifugal 5min of 1000rpm, remove cell culture fluid;
4., according to the ratio of 1:1000, by serum-free medium dilution DCFH-DA active oxygen detector probe, make its concentration be 10 μMs;
5. every bottle, cell after centrifugal adds the DCFH-DA that 5mL diluted makes its Eddy diffusion, cultivates 20min, and washs 3 times with serum-free medium, do not enter intracellular DCFH-DA to remove in 37 DEG C;
6. again suspended with serum-free medium by the cell after centrifugal, adjustment cell concentration makes sample sets consistent with matched group.Use fluorescence microplate reader to measure in excitation wavelength 488nm and emission wavelength 525nm place to absorb.
The results are shown in Figure 6, as shown in Figure 6, Formica fusca extract can reduce the generation of ROS in HSF, and the valid density that Formica fusca extract reduces ROS generation is 10
-4g/mL (* *: compared with blank group, P<0.01).
The foregoing is only the preferred embodiments of the present invention, is only illustrative for the purpose of the present invention, and nonrestrictive; Those of ordinary skill in the art understand, and can carry out many changes in the spirit and scope that the claims in the present invention limit to it, amendment, and even equivalence is changed, but all will fall within the scope of protection of the present invention.
Claims (7)
1. Formica fusca extract is preparing the application in cosmetics as effective ingredient.
2. application according to claim 1, is characterized in that, described Formica fusca extract can check melanin tumor cell proliferation, has certain freckle removing and whitening effect; Described Formica fusca extract can protect skin flbroblast vigor, significantly increases the secretion of collagen protein and hydroxyproline in skin, strengthens skin elasticity, has certain anti-aging effects; Described Formica fusca extract can promote superoxide dismutase (SOD) vigor and reduce the generation of active oxygen (ROS), has certain antioxidation.
3. application according to claim 2, is characterized in that, described Formica fusca extract is used for check melanin tumor cell proliferation, and the minimal effective concentration playing freckle removing and whitening effect is 10
-4g/mL; Described Formica fusca extract, for the protection of skin flbroblast vigor, significantly increases the secretion of collagen protein and hydroxyproline in skin, and strengthen skin elasticity, the minimal effective concentration playing anti-aging effects is 10
-4g/mL; Described Formica fusca extract is for promoting superoxide dismutase (SOD) vigor and reducing the generation of active oxygen (ROS), and the minimal effective concentration playing antioxidation is 10
-4g/mL.
4. application according to claim 1, is characterized in that, described Formica fusca is Polyhachis vicina Roger (Polyrhachis vicina Roger).
5. application according to claim 1, is characterized in that, the preparation method of described Formica fusca extract is:
(1) vacuum freeze drier dry Polyhachis vicina Roger queen is adopted to be pulverized by Polyhachis vicina Roger;
(2) 40% ethanol ultrasonic extraction 15 ~ 90min is adopted;
(3) extracting liquid filtering will obtained, collects filtrate, adopts rotary evaporator concentrate and collect concentrated solution;
(4) adopt vacuum freeze drier that concentrated solution is carried out drying after concentrated solution-80 DEG C of pre-coolings, obtain final extract, be placed in 4 DEG C and save backup.
6. application according to claim 1, is characterized in that, described cosmetics are selected from freckle whitening makeup, anti-aging cosmetics, antioxidation cosmetic product or its combination.
7. application according to claim 1, is characterized in that, described cosmetic forms is fancy soap, cleansing milk, bath gel, toner/smoothing toner, skin protection gel, facial treatment milk, protective skin cream, essence, eye cream, facial film, aerosol or spraying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410663622.2A CN104473834B (en) | 2014-11-19 | 2014-11-19 | Application of the extract from ants as active ingredient in cosmetics are prepared |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410663622.2A CN104473834B (en) | 2014-11-19 | 2014-11-19 | Application of the extract from ants as active ingredient in cosmetics are prepared |
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| Publication Number | Publication Date |
|---|---|
| CN104473834A true CN104473834A (en) | 2015-04-01 |
| CN104473834B CN104473834B (en) | 2017-06-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105753934A (en) * | 2015-06-16 | 2016-07-13 | 刘公德 | Antifreeze protein fluid extracting method |
| CN106727177A (en) * | 2015-11-20 | 2017-05-31 | 包捷梅 | A kind of selenium-rich bletilla striata silky ant powder cervacoria |
| CN108096283A (en) * | 2017-12-29 | 2018-06-01 | 广西壮族自治区中医药研究院 | Polyhachis vicina Roger extract is as the purposes for preparing prevention itch drug |
| CN108938512A (en) * | 2018-10-26 | 2018-12-07 | 含山县贝亲生物科技有限公司 | A kind of skin whitening, moisturizing body lotion of the extract containing acacia |
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|---|---|---|---|---|
| CN1163749A (en) * | 1996-04-26 | 1997-11-05 | 宇文军利 | Beautifying skin care cream and producing method thereof |
| CN1689587A (en) * | 2004-04-21 | 2005-11-02 | 四川省金蚂蚁生物技术发展有限公司 | Method for processing nano ant powder |
| CN103948536A (en) * | 2014-04-10 | 2014-07-30 | 哈尔滨医科大学 | Ant essence-placenta low-molecular active polypeptide composite anti-aging skin-care composition |
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2014
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1163749A (en) * | 1996-04-26 | 1997-11-05 | 宇文军利 | Beautifying skin care cream and producing method thereof |
| CN1689587A (en) * | 2004-04-21 | 2005-11-02 | 四川省金蚂蚁生物技术发展有限公司 | Method for processing nano ant powder |
| CN103948536A (en) * | 2014-04-10 | 2014-07-30 | 哈尔滨医科大学 | Ant essence-placenta low-molecular active polypeptide composite anti-aging skin-care composition |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105753934A (en) * | 2015-06-16 | 2016-07-13 | 刘公德 | Antifreeze protein fluid extracting method |
| CN106727177A (en) * | 2015-11-20 | 2017-05-31 | 包捷梅 | A kind of selenium-rich bletilla striata silky ant powder cervacoria |
| CN108096283A (en) * | 2017-12-29 | 2018-06-01 | 广西壮族自治区中医药研究院 | Polyhachis vicina Roger extract is as the purposes for preparing prevention itch drug |
| CN108096283B (en) * | 2017-12-29 | 2020-08-07 | 广西壮族自治区中医药研究院 | Application of polyrhachis vicina Roger extract in preparation of medicine for preventing and treating pruritus |
| CN108938512A (en) * | 2018-10-26 | 2018-12-07 | 含山县贝亲生物科技有限公司 | A kind of skin whitening, moisturizing body lotion of the extract containing acacia |
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| Publication number | Publication date |
|---|---|
| CN104473834B (en) | 2017-06-23 |
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