CN104473834B - Application of the extract from ants as active ingredient in cosmetics are prepared - Google Patents
Application of the extract from ants as active ingredient in cosmetics are prepared Download PDFInfo
- Publication number
- CN104473834B CN104473834B CN201410663622.2A CN201410663622A CN104473834B CN 104473834 B CN104473834 B CN 104473834B CN 201410663622 A CN201410663622 A CN 201410663622A CN 104473834 B CN104473834 B CN 104473834B
- Authority
- CN
- China
- Prior art keywords
- extract
- ants
- cosmetics
- ant
- vicina roger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Application the invention discloses extract from ants as active ingredient in cosmetics are prepared, belongs to filed of daily-use chemical industry.Extract from ants of the invention can suppress MC propagation, be acted on certain freckle removing and whitening；Extract from ants can also protect SF vigor, dramatically increase the secretion of collagen and hydroxyproline in skin, strengthen skin elasticity, with certain anti-aging effects；Extract from ants can lift superoxide dismutase (SOD) vigor and reduce the generation of active oxygen (ROS) simultaneously, with certain antioxidation.The features such as extract from ants of the invention has bioactivity stabilization, water solubility is good, can be used in freckle whitening makeup, anti-aging cosmetics, antioxidation cosmetic product or its combination as cosmetic actives.
Description
Technical field
The present invention relates to a kind of cosmetic actives, and in particular to extract from ants is preparing cosmetic as active ingredient
Application in product, belongs to filed of daily-use chemical industry.
Background technology
At present, cosmetics industry in daily life in occupation of considerable status.The daily use chemicals industry of China
Have developed rapidly, new product makes rapid progress, market is presented unprecedented prosperity scene.Many medicinal plant and animals are employed successively
In functional cosmetics production, preferable social and economic benefit is generated.Therefore, using traditional Chinese medicine theory and modern section
Cosmetics containing sp act composition prepared by technology are more and more highly valued in daily chemical industry.
Natural drug is long in the applicating history of beauty and skin care, has occurred early in Qin Han dynasty, is extremely contained to the Tang Dynasty
OK.Contained organic acid, grease, alkaloid, tannin, glycoside, essential oil, mucilaginous substance, protein, amino acid, dimension in natural drug
The materials such as raw element class, mineral matter, trace element, plant hormone can produce different effect and influence to human body skin.Such as tan
There is matter the effect of convergence skin, saponin(e there is decontamination contaminant releasing effect, acid to have, and anti-inflammation and sterilization is acted on, mucopolysaccharide has moisturizing
Effect, amino acid energy skin nutrition reduce wrinkle generation, protein and enhancing skin elasticity are also benefited.With science and technology
Progressive, contained numerous active components can be extracted and separate in natural drug, and this is also natural drug in household chemicals field
Application create condition.
Insect has worldwide obtained accreditation higher as a kind of new health products.The United Nations's grain and agricultural
Organize and evaluation higher is also gived to the nutritive value of insect, it is believed that insect protein is 21 century mankind's total nutrient health product.
Ant is people most familiar with one of with most common insect, and its population quantity is huge, widely distributed.Ant belongs to Arthropoda elder brother
Piroplasmea wing mesh Formicidae, mainly has kind more than 10 with using with the ant of medical value.Wherein, Polyhachis vicina Roger is that state food is defended
Unique ant with pharmaceutical food resource value of raw, medical approved by management.Confirmed by scientific research, Polyhachis vicina Roger
Ant have anti-inflammatory, relieving asthma, spasmolysis, analgesia, protect liver, beauty treatment and enhancing immune function of human body effect, can be rated as " microfauna nutrition
Treasure-house " and " natural drug processing factory ".
Ant is treated, i.e., with the speciality of the medicine-food two-purpose of ant, fusion ant nourishing, strengthening spleen, tonifying kidney, clearing and activating the channels and collaterals, QI invigorating
The functions such as promoting blood circulation, beauty treatment, immune, antiviral bidirectional modulation, anti-inflammatory, analgesia and calmness, improve body resisting fatigue ability and are immunized
Power, plays balanced health care's effect such as body nutrition and anti-aging.《Compendium of Materia Medica》With《A Supplement to the Compendium of Materia Medica》In also have
Record on ant " QI invigorating power, damp color " effect.At present, ant is often made prescription by Chinese scholar with important compatibility, is used
In scientific research and disease treatment.Ant and its preparation have many pharmacological actions, wherein, the anti-aging effects of ant and U.S.
Appearance effect has obtained relatively broad concern.Hamann proposed that human body will necessarily produce some certainly in vital movement in 1956
By base, can be reacted with internal some compositions, body is caused damage, cause human senility.Lipid peroxide in blood
Also can increase with the increase at age, and this material is the core substance for constituting fat brown fat, fat brown fat is deposited on nerve cell
In can make membrane protein matter and lipid that peroxidization occurs, cause its permeability changes, cell division, function is lost, plus
Fast cell ageing.And superoxide dismutase (SOD) can inactivate excessive superoxide anion, protection body exempts from superoxides certainly
By the infringement of base.The multiple biological activities composition that contains in ant body can antifatigue, enhancing muscle power, significantly remove free radical, prolong
Slow aging, extends the life-span.Multiple studies have shown that, ant Aqueous extracts have significant antifatigue, low temperature resistant, high temperature resistant, resist oxygen lack
Effect, superoxide dismutase (SOD) activity in aged small white mouse blood plasma and brain tissue can be significantly improved, reduce aged small
The effect of lipid peroxide and Free Radical Level in white mouse blood plasma and brain tissue.Additionally, it is also aging that body's immunity declines
Major reason.With the increase at age, body goes down to own cells with the separating capacity of exogenous cells, and exogenous are thin
The immune response of born of the same parents weakens, and immunological effect is substantially damaged.Ant water extraction liquid energy makes the rudimentary thymic hyperplasia of aged small white mouse, chest
Gland cortical thickening, peripheral lymphocyte increases, hence it is evident that promotes aged small white mouse lymphocytic cell division, increases cell DNA nRNA
Content, increases immunocompetent cell number.Therefrom from the point of view of medical angle, aging mainly includes " unbalance " and " deficient " two sides
Face, as yin and yang imbalance, disorder of qi and blood, so that internal organs void declines, vital essence cannot moisten foster, ultimately result in aging.And research shows,
Ant can strengthen the body resistance to consolidate the constitution, nourishing liver and kidney, and tonifying both YIN and YANG is qi-blood tonifying, promoting blood circulation and removing blood stasis, Appetizing spleen-tonifying.Therefore, ant has macrobiosis benefit
Longevity, face-beautifying health-care, effect of anti-aging.At present be clinically mainly used in immune dysfunction, endocrine disturbance and with decline
The experimental therapy of old relevant disease.
Modern science is analyzed, and 70 multiple nutritional components, white million kinds of its active component content are contained in Polyhachis vicina Roger body
Come out at the top in animal and plant.The composition related to the effect of ant face nourishing antidebilitation mainly includes：
1st, protein：Protein content in ant accounts for 42-67%.Containing extraordinary insect active high-quality protein in ant,
Can make face white and ruddy after taking, and brain cell, anti-aging can be activated.
2nd, amino acid：Contain 28 kinds of free amino acids in ant, including 8 kinds of amino acid necessary to human body, help
In maintenance body metabolism and energy supply.
3rd, vitamin and trace element：In ant containing vitamin B1, B2, B12, C, D, E etc. and calcium, iron, phosphorus, manganese, selenium,
The various trace elements of zinc etc. 20.Wherein selenium can be anti-oxidant, removes interior free yl.Zn content in ant particularly makes us looking steadily
Mesh.Zinc participates in brain cell development, improves immunologic function, promotes growth in humans's development, anti-aging, by physician and nutrition
Family is described as " Promethean fire flower ".Research display, zinc can also prevent eye illness, wrinkle resistant, strengthen immunity of organisms, so as to be kidney and spleen invigorating
There is provided reliable material base.
4th, triterpene compound：Contained triterpene compound has analgesic, calm, suppression histamine release etc. in ant
Effect, with significant lowering blood pressure and blood fat and the effects such as antiallergy, to hypertension, high fat of blood, insomnia and various respiratory system
Disease has therapeutic action.
5th, atriphos：Atriphos is the coenzyme being widely present in vivo, is the main of energy needed for histocyte
Source, participates in body fat, protein, sugar, nucleic acid, the metabolic process such as nucleotides, to absorb, secretion, contraction of muscle and carries out
Biochemical synthetic reaction provides required energy, with cell repair and regeneration is promoted, strengthens effect of cell metabolic activity.
6th, cursive script formaldehyde：Cursive script formaldehyde is the material with multiple biological activities that cannot manually synthesize.Cursive script formaldehyde energy
Regulation body's immunity, adjusts internal system, strengthens immunity of organisms, also has stronger Scavenging activity to virus.
7th, interleukin 2：Interleukins can strengthen body's immunity, activation cytokines, containment malignant change of cell
And it is antiviral.
8th, chitin：The chitin contained in ant shell is unique cation edibility animal origin in the world,
With two-way immunoregulation effect, and interior free yl can be removed, there is preferable health care prevention effect to sub-health state.
9th, formic acid：There is powerful tonifying Qi and blood containing formic acid in ant, all substances for finding so far
Cannot all compare therewith, this is also the source that ant can survive so far for nearly 200,000,000 years from Age of Dinosaur.
Ant, with its abundant nutritional ingredient and definite curative effect, is expected to as nutrition treasure-house and natural drug processing factory
As righting without staying evil, eliminating evil positive with notable freckle removing and whitening, anti-aging and oxidation resistant preferable cosmetics without hindering
Active ingredient.The features such as extract from ants of the invention has bioactivity stabilization, water solubility is good, can be effective as cosmetics
Composition is used in cosmetics.
The content of the invention
It is an object of the invention to provide a kind of new purposes of extract from ants, i.e., extract from ants is used as active ingredient
Application in cosmetics are prepared.
Wherein, the extract from ants can suppress MC propagation, be acted on certain freckle removing and whitening；Institute
Stating extract from ants can protect SF vigor, dramatically increase the secretion of collagen and hydroxyproline in skin,
Enhancing skin elasticity, with certain anti-aging effects；The extract from ants can lift superoxide dismutase (SOD) vigor
And the generation of active oxygen (ROS) is reduced, with certain antioxidation.
In the present invention, it is preferred that the extract from ants is used to suppress MC propagation, plays freckle removing and whitening work
MEC is 10-4g/mL；The extract from ants is used to protect SF vigor, dramatically increases skin
The secretion of collagen and hydroxyproline in skin, strengthens skin elasticity, and the MEC for playing anti-aging effects is 10-4g/mL；
The extract from ants is used to lift superoxide dismutase (SOD) vigor and reduces the generation of active oxygen (ROS), plays antioxygen
The MEC of change effect is 10-4g/mL。
In the present invention, it is preferred that described ant is Polyhachis vicina Roger (Polyrhachis vicina Roger).
In the present invention, it is preferred that the preparation method of described extract from ants is：
(1) Polyhachis vicina Roger queen is dried using vacuum freeze drier to crush Polyhachis vicina Roger；
(2) 15~90min is extracted using 40% EtOH Sonicate；
(3) the extract solution filtering that will be obtained, collects filtrate, and concentrate is concentrated and collected using rotary evaporator；
(4) concentrate is dried using vacuum freeze drier after -80 DEG C of precoolings of concentrate, obtains final product final extraction
Thing, is placed in 4 DEG C and saves backup.
In the present invention, it is preferred that the cosmetics are selected from freckle whitening makeup, anti-aging cosmetics, antioxidation cosmetic
Product or its combination.
In the present invention, it is preferred that the cosmetic forms are perfumed soap, mildy wash, shower cream, smoothing toner, skin care gel, shield
Skin emulsion, face cream, Essence, eye cream, facial mask, aerosol or spraying.
Brief description of the drawings
Fig. 1 is the inhibitory action figure (* that extract from ants is bred to MC：Compared with blank control group, P<
0.05；**：Compared with blank control group, P<0.01)；
Fig. 2 is protective effect figure (* * of the extract from ants to SF vigor：Compared with blank control group, P
<0.01)；
Fig. 3 is the facilitation figure (* that extract from ants secretes hydroxyproline to SF：With blank
Group is compared, P<0.05)；
Fig. 4 is the facilitation figure (* that extract from ants secretes collagen to SF：With blank control group phase
Than P<0.05)；
Fig. 5 is superoxide dismutase (SOD) vigor action diagram (* in extract from ants enhancing SF：With
Blank control group is compared, P<0.05)；
Fig. 6 is action diagram (the * * of active oxygen (ROS) generation in extract from ants reduction SF：With blank
Control group is compared, P<0.01), wherein, 0g/mL groups be blank control group.
Specific embodiment
Below by experiment and the present invention will be further described in conjunction with the embodiments, it should be understood that these embodiments
The purpose of illustration is only used for, protection scope of the present invention is never limited in.
The preparation of the extract from ants of embodiment 1
Polyhachis vicina Roger, buys from one prepared slices of Chinese crude drugs Co., Ltd of Harbin Pharmaceutical Group's generation.
Polyhachis vicina Roger is first dried with vacuum freeze drier, is crushed immediately after drying, and accurately weighs 60g ant powders, plus
Enter 40% ethanol solution of 2~6 times of ant powder volume, extracted under the ul-trasonic irradiation that frequency is 30~50KHZ, extract
Temperature is 40~90 DEG C, and extraction time is 15~90min, obtains extract solution, and the extract solution that will be obtained is filtered, and collects filter
Liquid, concentrates (50rpm, 40 DEG C) and collects concentrate with rotary evaporator.- 80 DEG C of precoolings of concentrate 2 hours, are put into vacuum refrigeration
Drying machine is dried, weighed, and obtains final product final extract, is placed in 4 DEG C and is saved backup.
The extract from ants of embodiment 2 suppresses the pharmacodynamic study of MC propagation in vitro
1. human melanoma cell (M14) is placed in 96 orifice plates, adjustment cell concentration is every hole 1 × 104, and in every hole
Add 200 μ L nutrient solutions, 37 DEG C of overnight incubations of constant temperature；
2. extract from ants is dissolved to concentration with nutrient solution and is respectively 10-3g/mL、10-4g/mL、10-5g/mL、10-6g/
mL、10-724h is cultivated in g/mL, and addition to above-mentioned Tissue Culture Plate；
3. MTT storing solutions are added into above-mentioned cell culture fluid, 4h is cultivated at dark in 37 DEG C；
4. after removing nutrient solution and adding a certain amount of DMSO, 15min is shaken at room temperature, and various kinds is determined at 490nm
The absorption of product.
Result is shown in Fig. 1, and as shown in Figure 1, extract from ants can suppress the propagation of MC, and this is acted on necessarily
In the range of be in dose dependent, extract from ants suppress M14 propagation valid density be 10-4g/mL(*：With blank control group phase
Than P<0.05；**：Compared with blank control group, P<0.01).
The extract from ants of embodiment 3 protects the pharmacodynamic study of SF vigor in vitro
1. HSF (HSF) is placed in 96 orifice plates, adjustment cell concentration is every hole 1 × 104, and every
Hole adds 200 μ L nutrient solutions, 37 DEG C of overnight incubations of constant temperature；
2. extract from ants is dissolved to concentration with nutrient solution and is respectively 10-4g/mL、10-5g/mL、10-6G/mL, and add
24h is cultivated into above-mentioned Tissue Culture Plate；
3. with H2O2Treatment cell 1h, cellular oxidative damage；
4. MTT storing solutions are added into above-mentioned cell culture fluid, 4h is cultivated at dark in 37 DEG C；
5. after removing nutrient solution and adding a certain amount of DMSO, 15min is shaken at room temperature, and various kinds is determined at 490nm
The absorption of product.
Result is shown in Fig. 2, and as shown in Figure 2, extract from ants can suppress by H2O2The HSF apoptosis of induction, and the protective effect exists
It is in dose dependent in certain limit, the valid density of extract from ants protection HSF cell viabilities is 10-5g/mL(**：With blank
Control is compared, P<0.01).
The extract from ants of embodiment 4 promotes the pharmacodynamic study of hydroxyproline secretion in SF in vitro
1. HSF (HSF) is placed in 6 orifice plates, adjustment cell concentration is every hole 1 × 105, and every
Hole adds 2mL nutrient solutions, 37 DEG C of overnight incubations of constant temperature；
2. extract from ants is dissolved to concentration with nutrient solution and is respectively 10-4g/mL、10-5G/mL, and add to above-mentioned thin
24h is cultivated in born of the same parents' culture plate；
3. each group cell supernatant is taken to be detected as testing sample；
4. (hydroxyproline is detected to the hydroxyproline content in each testing sample by hydroxyproline kit specification
Kit builds up Bioengineering Research Institute and provides by Nanjing).
Result is shown in Fig. 3, from the figure 3, it may be seen that extract from ants can promote the secretion of hydroxyproline in HSF, extract from ants promotees
The valid density for entering hydroxyproline secretion is 10-4g/mL(*：Compared with model group, P<0.05).
The extract from ants of embodiment 5 increases the pharmacodynamic study of collagen content in SF in vitro
1. HSF (HSF) is placed in 6 orifice plates, adjustment cell concentration is every hole 1 × 105, and every
Hole adds 2mL nutrient solutions, 37 DEG C of overnight incubations of constant temperature；
2. extract from ants is dissolved to concentration with nutrient solution and is respectively 10-4g/mL、10-5G/mL, and add to above-mentioned thin
24h is cultivated in born of the same parents' culture plate；
3. after cell is cracked with RIPA lysates, 13500rpm centrifugation 5min take the μ L of supernatant 100 as treating test sample
Product；
4. (glue is detected to the collagen content in each testing sample by collagen content detection ELISA kit specification
Original detection ELIS kits are provided by Uscn Life Science Inc companies).
Result is shown in Fig. 4, and as shown in Figure 4, extract from ants can increase the content of collagen in HSF, and extract from ants increases glue
The valid density of former content is 10-5g/mL(*：Compared with blank control group, P<0.05；**：Compared with blank, P<
0.01)。
The extract from ants of embodiment 6 increases the medicine of superoxide dismutase (SOD) vigor in SF in vitro
Effect learns research
1. HSF (HSF) is placed in 6 orifice plates, adjustment cell concentration is every hole 1 × 105, and every
Hole adds 2mL nutrient solutions, 37 DEG C of overnight incubations of constant temperature；
2. extract from ants is dissolved to concentration with nutrient solution and is respectively 10-4g/mL、10-5G/mL, and add to above-mentioned thin
24h is cultivated in born of the same parents' culture plate；
3. after cell is cracked with RIPA lysates, 13500rpm centrifugation 5min take the μ L of supernatant 20 as testing sample；
4. the SOD activity in each testing sample is detected by total SOD activity detection kits (WST-8) specification
(total SOD activity detection kits (WST-8 methods) are provided by green skies biotechnology research institute).
Result is shown in Fig. 5, and as shown in Figure 5, extract from ants can strengthen the activity of SOD in HSF, and extract from ants increases SOD
The valid density of activity is 10-4g/mL(*：Compared with blank control group, P<0.05).
The extract from ants of embodiment 7 reduces the pharmacodynamic study of active oxygen (ROS) generation in SF in vitro
1. HSF (HSF) is placed in 25cm2In blake bottle, adjustment cell concentration is every bottle 1 × 106, and
5mL nutrient solutions, 37 DEG C of overnight incubations of constant temperature are added at every bottle；
2. extract from ants is dissolved to concentration with nutrient solution and is respectively 10-4g/mL、10-5G/mL, and add to above-mentioned thin
24h is cultivated in born of the same parents' blake bottle；
3., by cell dissociation into suspended state, 1000rpm centrifugation 5min remove cell culture fluid；
4. according to 1:1000 ratio, DCFH-DA active oxygen detection probes are diluted with serum-free medium, make its concentration be
10μM；
5. the DCFH-DA that the every bottle of addition 5mL of cell after being centrifuged has diluted makes it suspend again, and 20min are cultivated in 37 DEG C,
And washed with serum-free medium 3 times, it is introduced into intracellular DCFH-DA to remove；
6. the cell after centrifugation is suspended with serum-free medium again, adjustment cell concentration makes sample sets with control group phase
Unanimously.Absorption is determined at excitation wavelength 488nm and launch wavelength 525nm using fluorescence microplate reader.
Result is shown in Fig. 6, it will be appreciated from fig. 6 that extract from ants can reduce the generation of ROS in HSF, extract from ants reduces ROS
The valid density of generation is 10-4g/mL(**：Compared with blank control group, P<0.01).
The preferred embodiments of the present invention are the foregoing is only, is merely illustrative for the purpose of the present invention, and it is nonrestrictive；
Those of ordinary skill in the art understand that can carry out many to it in the spirit and scope that the claims in the present invention are limited changes
Become, modification, or even equivalent change, but fall within protection scope of the present invention.
Claims (3)
1. extract from ants is preparing answering in can suppressing the cosmetics that MC is bred as sole active ingredient
With described ant is Polyhachis vicina Roger (Polyrhachis vicina Roger), the preparation method of the extract from ants
For：
(1) Polyhachis vicina Roger queen is dried using vacuum freeze drier to crush Polyhachis vicina Roger；
(2) 15~90min is extracted using 40% EtOH Sonicate；
(3) the extract solution filtering that will be obtained, collects filtrate, and concentrate is concentrated and collected using rotary evaporator；
(4) concentrate is dried using vacuum freeze drier after -80 DEG C of precoolings of concentrate, obtains final product final extract, put
Saved backup in 4 DEG C.
2. application according to claim 1, it is characterised in that the extract from ants is used to suppress MC increasing
Grow, the MEC for playing freckle removing and whitening effect is 10-4g/mL。
3. application according to claim 1, it is characterised in that the cosmetic forms be perfumed soap, mildy wash, shower cream,
Smoothing toner, skin care gel, facial treatment milk, face cream, Essence, eye cream, facial mask, aerosol or spraying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410663622.2A CN104473834B (en) | 2014-11-19 | 2014-11-19 | Application of the extract from ants as active ingredient in cosmetics are prepared |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410663622.2A CN104473834B (en) | 2014-11-19 | 2014-11-19 | Application of the extract from ants as active ingredient in cosmetics are prepared |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104473834A CN104473834A (en) | 2015-04-01 |
| CN104473834B true CN104473834B (en) | 2017-06-23 |
Family
ID=52748540
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410663622.2A Active CN104473834B (en) | 2014-11-19 | 2014-11-19 | Application of the extract from ants as active ingredient in cosmetics are prepared |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104473834B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105753934A (en) * | 2015-06-16 | 2016-07-13 | 刘公德 | Antifreeze protein fluid extracting method |
| CN106727177A (en) * | 2015-11-20 | 2017-05-31 | 包捷梅 | A kind of selenium-rich bletilla striata silky ant powder cervacoria |
| CN108096283B (en) * | 2017-12-29 | 2020-08-07 | 广西壮族自治区中医药研究院 | Application of polyrhachis vicina Roger extract in preparation of medicine for preventing and treating pruritus |
| CN108938512A (en) * | 2018-10-26 | 2018-12-07 | 含山县贝亲生物科技有限公司 | A kind of skin whitening, moisturizing body lotion of the extract containing acacia |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1163749A (en) * | 1996-04-26 | 1997-11-05 | 宇文军利 | Beautifying skin care cream and producing method thereof |
| CN1689587A (en) * | 2004-04-21 | 2005-11-02 | 四川省金蚂蚁生物技术发展有限公司 | Method for processing nano ant powder |
| CN103948536A (en) * | 2014-04-10 | 2014-07-30 | 哈尔滨医科大学 | Ant essence-placenta low-molecular active polypeptide composite anti-aging skin-care composition |
-
2014
- 2014-11-19 CN CN201410663622.2A patent/CN104473834B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1163749A (en) * | 1996-04-26 | 1997-11-05 | 宇文军利 | Beautifying skin care cream and producing method thereof |
| CN1689587A (en) * | 2004-04-21 | 2005-11-02 | 四川省金蚂蚁生物技术发展有限公司 | Method for processing nano ant powder |
| CN103948536A (en) * | 2014-04-10 | 2014-07-30 | 哈尔滨医科大学 | Ant essence-placenta low-molecular active polypeptide composite anti-aging skin-care composition |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104473834A (en) | 2015-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104473834B (en) | Application of the extract from ants as active ingredient in cosmetics are prepared | |
| KR101294762B1 (en) | Functional soap and manufacturing method of it | |
| CN102048905A (en) | Oral liquid for benefiting qi, nourishing blood and beautifying face and preparation process thereof | |
| CN102550779A (en) | Preserved fruit and production method thereof | |
| KR101280300B1 (en) | Health-aid food used the ginseng seed oil by main raw material | |
| CN104784473A (en) | Earthworm protein health care product | |
| CN108743500A (en) | Not only oral administration but also can external application beautifying face and moistering lotion compound peptide functional food and preparation method thereof | |
| KR102320299B1 (en) | Functional soap composition containing natural ingredients | |
| CN102389009B (en) | Health tea with whitening and beautifying effect | |
| CN105193699B (en) | A kind of compound rhodamine oil facial mask | |
| CN106165739A (en) | The manufacture method of the LIUPUCHA of dental caries can be prevented and treated | |
| CN108771757A (en) | A kind of health-care foot patch composition and health-care foot patch | |
| CN109568163A (en) | A kind of food grade moisturizing liquid and preparation method thereof | |
| CN108815015A (en) | A kind of eye mask and its production technology | |
| CN102002441B (en) | Plant balm for improving physical and mental harmonious degree | |
| CN102308989B (en) | Health care composition of formica rufa, grape and propolis extracts | |
| CN107156332A (en) | A kind of complex health care product of strengthen immunity | |
| CN104413526B (en) | A kind of can the pomegranate nutritious drink and preparation method thereof of skin care | |
| CN107412451A (en) | Ginseng agalloch eaglewood and preparation method thereof | |
| CN103893381B (en) | Composition with lead-expelling function and its preparation method and application | |
| CN105995711A (en) | Fructus phyllanthi compound preparation and preparation method thereof | |
| CN102614368B (en) | Combination for removing beverage and preparing method | |
| CN105456114A (en) | Whitening cosmetic containing Rhodiola rosea extract, polygonum multiflorum extract and ganoderma extract | |
| CN104546642A (en) | Preparation method of whitening facial mask | |
| CN101130028A (en) | Tianzijiang medicament for preventing senescence and treating hyperplasia of prostate gland |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |