CN108143952A - A kind of preparation method of plant hypoglycemic agent - Google Patents
A kind of preparation method of plant hypoglycemic agent Download PDFInfo
- Publication number
- CN108143952A CN108143952A CN201711146932.7A CN201711146932A CN108143952A CN 108143952 A CN108143952 A CN 108143952A CN 201711146932 A CN201711146932 A CN 201711146932A CN 108143952 A CN108143952 A CN 108143952A
- Authority
- CN
- China
- Prior art keywords
- preparation
- hypoglycemic agent
- raw materials
- paste
- plant hypoglycemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003472 antidiabetic agent Substances 0.000 title claims abstract description 16
- 229940126904 hypoglycaemic agent Drugs 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 24
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 18
- 241000196324 Embryophyta Species 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 238000009835 boiling Methods 0.000 claims abstract description 10
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 9
- 235000002732 Allium cepa var. cepa Nutrition 0.000 claims abstract description 8
- 244000075850 Avena orientalis Species 0.000 claims abstract description 8
- 235000007319 Avena orientalis Nutrition 0.000 claims abstract description 8
- 235000007558 Avena sp Nutrition 0.000 claims abstract description 8
- 239000009636 Huang Qi Substances 0.000 claims abstract description 8
- 244000302512 Momordica charantia Species 0.000 claims abstract description 8
- 235000009811 Momordica charantia Nutrition 0.000 claims abstract description 8
- 235000009812 Momordica cochinchinensis Nutrition 0.000 claims abstract description 8
- 235000018365 Momordica dioica Nutrition 0.000 claims abstract description 8
- 240000008042 Zea mays Species 0.000 claims abstract description 8
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims abstract description 8
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims abstract description 8
- 235000005822 corn Nutrition 0.000 claims abstract description 8
- 239000000284 extract Substances 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 8
- 239000007787 solid Substances 0.000 claims abstract description 8
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 7
- 238000000227 grinding Methods 0.000 claims abstract description 5
- 238000004821 distillation Methods 0.000 claims abstract description 3
- 244000291564 Allium cepa Species 0.000 claims abstract 3
- 240000001949 Taraxacum officinale Species 0.000 claims abstract 2
- 239000008367 deionised water Substances 0.000 claims description 5
- 229910021641 deionized water Inorganic materials 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 15
- 239000003814 drug Substances 0.000 abstract description 5
- 238000000605 extraction Methods 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 10
- 206010012601 diabetes mellitus Diseases 0.000 description 9
- 241000234282 Allium Species 0.000 description 5
- 102000004877 Insulin Human genes 0.000 description 5
- 108090001061 Insulin Proteins 0.000 description 5
- 241000245665 Taraxacum Species 0.000 description 5
- 229940125396 insulin Drugs 0.000 description 5
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 229940127003 anti-diabetic drug Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229940123208 Biguanide Drugs 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000002249 Diabetes Complications Diseases 0.000 description 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 description 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
- 206010012655 Diabetic complications Diseases 0.000 description 1
- 206010066786 Diabetic keratopathy Diseases 0.000 description 1
- 206010018473 Glycosuria Diseases 0.000 description 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010033645 Pancreatitis Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 229940100389 Sulfonylurea Drugs 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000002279 cholagogic effect Effects 0.000 description 1
- 201000001352 cholecystitis Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 208000033679 diabetic kidney disease Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 210000002189 macula lutea Anatomy 0.000 description 1
- 239000011812 mixed powder Substances 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to Chinese medicine preparation fields, particularly disclose a kind of preparation method of plant hypoglycemic agent.The preparation method of the plant hypoglycemic agent, it is characterized in that：Using Radix Astragali, dandelion, balsam pear, onion, oat and corn stigma as raw material, above-mentioned raw materials are cleaned, dry rear co-grinding into powdered；The powder of mixing is added into water boiling, finally concentration is sticky paste；Paste raw materials are placed in nitrogen environment and are lyophilized, and solid extract product is obtained through distillation.Step of the present invention is simple, and raw material is common to be easy to get, and extraction conditions are mild, and production cost is low, and product good absorption effect is significant in efficacy, without side-effects, safe, suitable for wide popularization and application.
Description
（One）Technical field
The present invention relates to Chinese medicine preparation field, more particularly to a kind of preparation method of plant hypoglycemic agent.
（Two）Background technology
Diabetic has the clinical manifestation of typical three-many-one-little, i.e., more drinks, more food, diuresis, sale, these contents are in
Doctor is just on the books in the middle, i.e. the diabete of the traditional Chinese medical science.Diabetes are a kind of chronic diseases, and above-mentioned uncomfortable diseases are not only brought to patient
Outside shape, it can also cause a variety of chronic complicating diseases, such as a series of illnesss of heart, blood vessel, eyes, kidney and nervous system, seriously
Threaten daily life, the health and lives of diabetic.Common diabetic complication has following a few classes：Diabetic keratopathy eye
Disease, diabetic neuropathy, vasculopathy of lower extremity in diabetes change, diabetic nephropathy, diabetic cardiopathy.Thus patient needs to grow
Phase controls blood glucose.
At present, the drug for treating diabetes is mainly human insulin, sulfonylureas and biguanides.But antidiabetic drug
Object has side effect, takes the injury that can cause Liver and kidney function for a long time, it is therefore desirable to which providing one kind can take for a long time without leading
Cause liver, kidney, neural equivalent damage drug.
（Three）Invention content
In order to compensate for the shortcomings of the prior art, the present invention provides the plant hypoglycemic agent that a kind of step is simple, production cost is low
Preparation method.
The present invention is achieved through the following technical solutions：
A kind of preparation method of plant hypoglycemic agent, includes the following steps：
（1）Using Radix Astragali, dandelion, balsam pear, onion, oat and corn stigma as raw material, above-mentioned raw materials are cleaned, dry rear mixed powder
It is broken into powdered；
（2）The powder of mixing is added into water boiling, finally concentration is sticky paste；
（3）Paste raw materials are placed in nitrogen environment and are lyophilized, solid extract product is obtained through distillation.
The present invention is lyophilized and is distilled by crushing, boiling, concentration, nitrogen carries out mixed processing, maximum journey to Chinese medicine material
Degree extracts the active ingredient in raw material, while boiling concentration and frozen dried condition are relatively simple, will not destroy original
The activity of material makes it have larger function and effect.
The present invention more excellent technical solution be：
Step（1）In, Radix Astragali, dandelion, balsam pear, onion, oat and corn stigma weight proportion be：6-15:6-15:20-40:
20-40:20-40:20-40。
Step（2）In, the deionized water boiling at 120-220 DEG C for accounting for 3-5 times of its volume is added in into the powder of mixing
15-30min, be concentrated under reduced pressure after at 50-72 DEG C.
Step（3）In, paste raw materials are lyophilized in -10 DEG C to -30 DEG C of nitrogen environment, later under 1.5-5Pa environment
Subliming water obtains solid extract product.
The present invention realizes the constituents extraction of natural plant raw material, retains active principle, while do not influence active principle
Activity, so as to get hypoglycemic agent there is clearing heat and detoxicating, blood lipid-reducing blood sugar-decreasing, clearing liver cholagogic, to hypertension, hyperlipidemia, glycosuria
The diseases such as disease have the effect of good.
Step of the present invention is simple, and raw material is common to be easy to get, and extraction conditions are mild, and production cost is low, product good absorption effect, treats
Effect is notable, without side-effects, safe, suitable for wide popularization and application.
（Four）Specific embodiment
Embodiment 1：A kind of preparation method of plant hypoglycemic agent
（1）It, will be above-mentioned using Radix Astragali 60g, dandelion 60g, balsam pear 200g, onion 200g, oat 200g, corn stigma 200g as raw material
Raw material cleaning dries rear co-grinding into powdered；
（2）The deionized water for accounting for 3-5 times of its volume boiling 15-30min at 120-220 DEG C is added in into the powder of mixing, it
It is concentrated under reduced pressure after at 50-72 DEG C, obtains sticky paste；
（3）Paste raw materials are lyophilized in -10 DEG C to -30 DEG C of nitrogen environment, later the subliming water under 1.5-5Pa environment,
Obtain solid extract product.
Embodiment 2：
（1）It, will be upper using Radix Astragali 150g, dandelion 150g, balsam pear 400g, onion 400g, oat 400g, corn stigma 400g as raw material
It states raw material cleaning, dry rear co-grinding into powdered；
（2）The deionized water for accounting for 3-5 times of its volume boiling 15-30min at 120-220 DEG C is added in into the powder of mixing, it
It is concentrated under reduced pressure after at 50-72 DEG C, obtains sticky paste；
（3）Paste raw materials are lyophilized in -10 DEG C to -30 DEG C of nitrogen environment, later the subliming water under 1.5-5Pa environment,
Obtain solid extract product.
Embodiment 3：
（1）It, will be upper using Radix Astragali 100g, dandelion 100g, balsam pear 100g, onion 300g, oat 300g, corn stigma 300g as raw material
It states raw material cleaning, dry rear co-grinding into powdered；
（2）The deionized water for accounting for 3-5 times of its volume boiling 15-30min at 120-220 DEG C is added in into the powder of mixing, it
It is concentrated under reduced pressure after at 50-72 DEG C, obtains sticky paste；
（3）Paste raw materials are lyophilized in -10 DEG C to -30 DEG C of nitrogen environment, later the subliming water under 1.5-5Pa environment,
Obtain solid extract product.
By the plant hypoglycemic agent being prepared be applied to clinical test, using effect is good, it is special go out following typical case
Case illustrates.
（1）Mr. Wang, 54 years old, Hulun Buir Sandy Land Yakeshi City people, illness 9 years made a definite diagnosis, starts to eat antidiabetic drug for 08 year
It does not act on, starts insulin injection afterwards, injection dosage is morning 18U, middle 18U, evening 28U；Last year because pancreatitis is hospitalized one month, after
Cholecystitis calculus is hospitalized one month again, daily to like drinking.
Begin to use the product treatment of the present invention month, the dosage of product of the present invention is measured by g, and track record is as follows.
（2）Mrs Chen, 57 years old, Langfang City people from Anci District, illness 15 years started to use insulin for 06 year, and injection dosage is early
12U, evening 12U, preceding 12U is slept, insulin uses two brands, and dosage rises year by year, and blood glucose is more steady, there is complication sign, hand
Refer to numb, macula lutea is seen on eyeground.
Begin to use the product treatment of the present invention month, the dosage of product of the present invention is measured by g, and track record is as follows.
（3）Mr. Yang, 62 years old, people from Heilungkiang, illness 1 year, daily insulin injection dosage for morning 13U, evening 13U, sleep before
13U；Begin to use the product treatment of the present invention June, the dosage of product of the present invention is measured by g, and track record is as follows.
By the model case of above-mentioned clinical test it is found that product produced by the present invention has preferable use for diabetes
Effect, continuous use can substitute insulin, and using effect is more preferable in one month or so completely, have no toxic side effect and dependence,
Long-term use can then effect a radical cure diabetes, and without recurrence.
Claims (4)
1. a kind of preparation method of plant hypoglycemic agent, it is characterized in that, include the following steps：（1）With Radix Astragali, dandelion, balsam pear, ocean
Green onion, oat and corn stigma are raw material, and above-mentioned raw materials are cleaned, dry rear co-grinding into powdered；（2）The powder of mixing is added
Water boiling, finally concentration are sticky paste；（3）Paste raw materials are placed in nitrogen environment and are lyophilized, obtaining solid through distillation carries
Take produce product.
2. the preparation method of plant hypoglycemic agent according to claim 1, it is characterised in that：Step（1）In, Radix Astragali, Pu Gong
English, balsam pear, onion, oat and corn stigma weight proportion be：6-15:6-15:20-40:20-40:20-40:20-40.
3. the preparation method of plant hypoglycemic agent according to claim 1, it is characterised in that：Step（2）In, toward the powder of mixing
Added in end and account for the deionized water of 3-5 times of its volume boiling 15-30min at 120-220 DEG C, depressurized after at 50-72 DEG C
Concentration.
4. the preparation method of plant hypoglycemic agent according to claim 1, it is characterised in that：Step（3）In, paste raw materials
It is lyophilized in -10 DEG C to -30 DEG C of nitrogen environment, the subliming water under 1.5-5Pa environment, obtains solids extract produce later
Product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711146932.7A CN108143952A (en) | 2017-11-17 | 2017-11-17 | A kind of preparation method of plant hypoglycemic agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711146932.7A CN108143952A (en) | 2017-11-17 | 2017-11-17 | A kind of preparation method of plant hypoglycemic agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108143952A true CN108143952A (en) | 2018-06-12 |
Family
ID=62468773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711146932.7A Pending CN108143952A (en) | 2017-11-17 | 2017-11-17 | A kind of preparation method of plant hypoglycemic agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108143952A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111802587A (en) * | 2019-04-10 | 2020-10-23 | 黑龙江省中医药科学院 | Composition with effects of reducing blood sugar and blood fat and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401881A (en) * | 2008-11-18 | 2009-04-08 | 向昌荣 | Chinese medicinal composition for treating poison produced by venomous insects |
| CN104069384A (en) * | 2014-07-22 | 2014-10-01 | 河南中医学院 | Traditional Chinese medicine powder for treating type II diabetes mellitus qi deficiency and blood stasis |
-
2017
- 2017-11-17 CN CN201711146932.7A patent/CN108143952A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101401881A (en) * | 2008-11-18 | 2009-04-08 | 向昌荣 | Chinese medicinal composition for treating poison produced by venomous insects |
| CN104069384A (en) * | 2014-07-22 | 2014-10-01 | 河南中医学院 | Traditional Chinese medicine powder for treating type II diabetes mellitus qi deficiency and blood stasis |
Non-Patent Citations (3)
| Title |
|---|
| 崔泽等: "苦芪降糖胶囊对实验性糖尿病的影响", 《中国医院药学杂志》 * |
| 胡维勤: "《"三高"吃对才有效"》", 31 May 2017, 黑龙江科学技术出版社 * |
| 臧俊歧等: "《膳食内调 穴位外治痛风》", 31 March 2016, 哈尔滨：黑龙江科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111802587A (en) * | 2019-04-10 | 2020-10-23 | 黑龙江省中医药科学院 | Composition with effects of reducing blood sugar and blood fat and application thereof |
| CN111802587B (en) * | 2019-04-10 | 2023-07-11 | 黑龙江省中医药科学院 | Composition with blood glucose and blood lipid reducing effects and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103750107B (en) | Health-care product with blood glucose reducing function | |
| CN102526479B (en) | Health-care medicine formula with functions of enhancing immunity and lowering blood sugar | |
| CN102526478B (en) | Formula of health-care medicine with functions of strengthening immunity and reducing blood sugar | |
| CN102793741A (en) | Beautiful millettia root extract and application thereof | |
| CN105341893A (en) | Composition for assisting in reducing blood glucose and application | |
| CN104905237A (en) | Inonotus obliquus composite electuary and production method thereof | |
| CN108743669A (en) | Chinese medicine composition and its preparation method and application for treating goat | |
| CN108143952A (en) | A kind of preparation method of plant hypoglycemic agent | |
| CN109771578A (en) | The composition for preventing and treating diabetes and complication | |
| CN104474103B (en) | A kind of natural plant hypoglycemic agent and preparation method thereof | |
| CN101732386B (en) | Medicinal composition for treating gout, preparation method thereof and purposes thereof | |
| CN103719997A (en) | Guava leaf solid beverage | |
| CN103656196B (en) | Chinese medicine composition and the preparation method of the pruitus that treatment diabetes cause | |
| CN104288527B (en) | It is a kind of to be used to treat Chinese medicine composition of diabetes and preparation method and application | |
| CN102225082B (en) | Medicament for preventing and treating diabetes and complications thereof and preparation method thereof | |
| CN110314219A (en) | A kind of spray for diabetic complication | |
| CN103751255A (en) | Pachymaran composition for decreasing blood sugar and preparation method thereof | |
| CN104256618A (en) | Food, health care product or medicine composition with blood sugar reduction function | |
| CN104277958A (en) | Health wine for reducing blood sugar level | |
| CN103961551A (en) | Traditional Tibetan medicine for treating diabetes | |
| CN103372055B (en) | Extraction process, the total polyphenols composition and use thereof of hypoglycemic activity composition total polyphenols in Cortex Cinnamomi | |
| CN104524359B (en) | A kind of Chinese medicine composition, its preparation method and application | |
| CN111803559B (en) | Eggplant peel composition with blood sugar reducing effect and preparation method and application thereof | |
| CN102113529B (en) | Flour with function of treating diabetes and preparation method thereof | |
| CN101822698A (en) | Method for preparing black fungus and pantotrichum hypoglycemic composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180612 |