Chinese medicine composition and the preparation method of the pruitus that treatment diabetes cause
Technical field
The invention belongs to technical field of traditional Chinese medicines, be specifically related to a kind of Chinese medicine composition for the treatment of the pruitus that diabetes cause, also relate to the preparation method of this Chinese medicine composition.
Background technology
Diabetes are one group of metabolic diseases taking hyperglycaemia as feature. Hyperglycaemia be due to defect of insulin secretion or its biological agent impaired, or both have concurrently and cause. Long-standing hyperglycaemia when diabetes, causes various tissues, particularly chronic lesion, the dysfunction of eye, kidney, heart, blood vessel, nerve.
1. inherent cause
All there is obvious genetic heterogeneity in 1 type or diabetes B. There is family's morbidity tendency in diabetes, 1/4~1/2 patient has diabetes family history. Genetic syndromes more than having clinically 60 kinds at least can be with diabetes. Type 1 diabetes has multiple DNA site to participate in morbidity, wherein close with DQ loci polymorphism relation in HLA antigen gene. Find multiple clear and definite gene mutation at diabetes B, as insulin gene, insulin receptor gene, glucokinase gene, chondriogen etc.
2. environmental factor
Too much, it is the topmost environmental factor of diabetes B that physical exertion reduces the obesity causing, and the individuality with diabetes B genetic predisposition is easily fallen ill in feed. There is immune system abnormality in type 1 diabetes patient, in some virus, as Coxsackie virus, rubella virus, causes autoimmune response after the infection such as parotid gland virus, destroys insulin β cell.
There is no at present the method for radical cure diabetes, but can control diabetes well by multiple treatment means. Mainly comprise 5 aspects: diabetic's education, self-monitoring of blood glucose, dietary therapy, exercise therapy and medicine treatment.
(1) general treatment
1. education
Educate diabetic and understand the ABC of diabetes, establish the confidence of Fighting Disease, how to control diabetes, control diabetes well to healthy benefit. Formulate appropriate therapeutic scheme according to each diabetic's state of an illness feature.
2. self-monitoring of blood glucose
Along with progressively popularizing of small-size fast Instrument for Measuring Blood Sugar, patient can adjust at any time according to blood sugar level the dosage of hypoglycemic drug. When type 1 diabetes carries out intensive treatment, at least monitor 4 blood sugar (before the meal) every day, will monitor 8 times (before breakfast, lunch and dinner are forward and backward, sleep evening and morning 3:00) when blood sugar is unstable. When intensive treatment, fasting blood-glucose should be controlled at below 7.2 mM/ls, and two hours blood glucoses are less than 10mmol/L after the meal, and HbA1c is less than 7%. The frequency of diabetes B patient self-monitoring of blood glucose can suitably reduce.
(2) medicine treatment
1. oral drug therapy
(1) sulfonylurea drugs 2 type DM patients are through diet control, and motion, reduces after the treatments such as body weight, and curative effect is dissatisfied all available sulfonylurea drugs of person still. Because hypoglycemic mechanism mainly stimulates insulin secretion, so to there being certain islet function person curative effect better. Lighter to some age of onset, the not fat diabetic of the bodily form also has certain curative effect in early days. But when overweight people is used to sulfonylurea drugs, pay special attention to diet control, body weight is declined gradually, better with biguanides or the coupling of alpha-glucosidase restrainer antidiabetic drug. Following situations belongs to contraindication: the one, and serious liver, renal insufficiency; The 2nd, severe infection during wound and major operation, is used insulinize instead temporarily; The 3rd, during Diabetic ketosis, DKA, use insulinize instead temporarily; The 4th, pregnant diabetic women, gestation hyperglycaemia has the effect of teratogenesis shape to fetus, premature labor, stillbirth incidence are high, therefore should strictly control blood sugar, fasting blood-glucose should be controlled at below 105 milligrams/deciliter (5.8 mM/ls), 2 hours blood glucoses are controlled at below 120 milligrams/deciliter (6.7 mM/ls) after the meal, should not use OHA but control blood sugar; The 5th, irritated or occur obvious adverse reaction to sulfonylurea drugs.
(2) the hypoglycemic main mechanism of biguanides is to increase the utilization of peripheral tissues to glucose, increases the anerobic glycolysis of glucose, reduces the absorption of intestines and stomach to glucose, reduces body weight. 1. idicatio endomorphy type diabetes B, alone dietary therapy effect is unsatisfied with person; The alone sulfonylurea drugs effect of diabetes B is bad, can add biguanides; Type 1 diabetes insulinize unstable condition, can reduce insulin dose with biguanides; When diabetes B secondary failure is used insulinize instead, can add with biguanides, can reduce insulin dosage. 2. the serious liver of contraindication, kidney, the heart, lung disease, deeline, malnutrition, Hypoxic disease; Diabetic ketosis, DKA; Stress when situation, suspend biguanides with severe infections, operation, wound etc., use insulinize instead; The gestational period. 3. bad reaction one is gastrointestinal reaction. The most common, show as that nauseating, vomiting, appetite decline, stomachache, diarrhoea, incidence can reach 20%. For avoiding these bad reactions, should in meal or after the meal, take medicine. The 2nd, headache, dizzy, metallic taste. The 3rd, lactic acidosis, is more common in long-term, extensive application phenformin, with liver, renal hypofunction, and Hypoxic disease, when acute infection, enterogastric diseases, melbine causes that acidosic chance is less.
(3) α glucosidase inhibitor 1 type and diabetes B all can use, can with sulfonylureas, biguanides or insulin coupling. 1. Voglibose (voglibose) is at once oral before the meal. ②Bai Tang Ping and Acarbose (acarbose) are at once oral before the meal. Main adverse reaction has: stomachache, intestinal tympanites, diarrhoea, passage of gas by anus increase.
(4) insulin sensitizer has enhancing insulin action, improves glycometabolism. Can be alone, also can use sulfonylureas, biguanides or insulin coupling. There are hepatopathy or cardiac insufficiency person person to apply.
(5) meglitinide insulin succagoga 1. Repaglinide (NovoNorm) be quick Drugs Promoting Insulin Secretion, at once oral before the meal, when each dinner, take the disobedience of not having meal. 2. Nateglinide (Tang Li) effect is similar to Repaglinide.
2. insulinize
Insulin preparation has animal insulin, actrapid monotard and insulin analog. Be divided into fugitive, middle effect and protamine zine insulin according to action time, and made mix preparation, as Novolin 30R, excellently secrete woods 70/30.
(1) type 1 diabetes needs insulinize. Nonreinforcement curer injects 2~3 every day, and intensive treatment person injects 3~4 every day, or uses insulin pump in treatment. Need often to adjust dosage.
(2) diabetes B OHA inefficacy person first adopts therapeutic alliance mode, method is former constant by orally-taken blood sugar reducing pharmaceutical quantities, sleep and injected intermediate-acting insulins or Recent Development of Long-acting Insulin Analogs 10: 00 evening before yesterday, generally adjusted 1 time every 3 days, object is that fasting blood-glucose drops to 4.9~8.0 mM/ls, nonresponder's OHA of stopping using, changes into and injects insulin every day 2 times.
The maximum bad reaction of insulinize is hypoglycemia.
(3) exercise therapy
Increase physical exertion and can improve the sensitiveness of body to insulin, reduce body weight, reduce body fat amount, strengthen muscle power, improve ability to work and quality of life. Intensity and the time length of motion should be determined according to patient's general health, find the amount of exercise and the interested project of patient that are applicable to patient. Forms of motion can be various, as taken a walk, skelp, callisthenics, dance, practise taijiquan, run, swimming etc.
(4) dietary therapy
Dietary therapy is the basis of all kinds treating diabetes, and the alone dietary therapy of a part of levis diabetes patient just can be controlled the state of an illness.
1. total amount of heat
The requirement of total amount of heat will be determined according to composite factors such as patient's age, sex, height, body weight, muscular labor momentum, the state of an illness. First to calculate everyone SBW, can be with reference to following formula: SBW (kg)=height (cm)-105 or SBW (kg)=[height (cm)-100] × 0.9; Women's SBW should deduct 2kg again. Also can be according to the acquisition of tabling look-up of age, sex, height. After calculating SBW, estimate every kilogram of SBW caloric requirement according to everyone daily physical exertion situation again.
Calculate after required calorie amount every day according to SBW, also will be adjusted accordingly according to other situations of patient. Children, puberty, lactation, malnutrition, become thin and have chronic wasting disease should increase as one sees fit total amount of heat. Overweight people will strictly limit total amount of heat and fat content, gives low caloric diet, and every day, total amount of heat was no more than 1500 kilocalories, is generally advisable monthly to reduce by 0.5~1.0kg, in the time approaching SBW, then presses preceding method and calculates total amount of heat every day. In addition, older person needs heat few compared with little person of age, and woman is fewer than man institute calorific requirement.
2. carbohydrate
4 kilocalories of every gram of heat production of carbohydrate, are the main sources of heat, now think that carbohydrate should account for 55%~65% of diet total amount of heat, and available formula below calculates:
According to China's people's lives custom, can enter staple food (rice or face) 250~400g, can do as follows according to a preliminary estimate, rest person's staple food every day 200~250g, slight physical labourer 250~300g, moderate physical labourer 300~400g, more than heavy worker 400g.
3. protein
4 kilocalories of every gram of quantities of heat production of protein. Account for 12%~15% of total amount of heat. The requirement of protein is at the about 1g of the every kg body weight of adult. Children, pregnant woman, women breast-feeding their children, malnutrition, becomes thin, and has deeline person should be increased to every kg body weight 1.5~2.0g. Diabetogenous nephrosis patient should reduce protein intake, every kg body weight 0.8g, if existing renal insufficiency should be taken in high quality protein matter, intake should further reduce to every kg body weight 0.6g.
4. fat
The energy of fat is higher, 9 kilocalories of every gram of quantities of heat production. Account for total amount of heat 25%, be generally no more than 30%, per kg body weight per day 0.8~1g. Animal tallow is mainly containing saturated fatty acid. Many containing unrighted acid in vegetable oil, diabetic easily suffers from atherosclerotic, and it is main should adopting vegetable oil.
The caused pruitus of diabetes has been brought great misery to patient, serious impact patient's rest and normal life.
For the defect of above-mentioned methods for the treatment of, need to find a kind of medicine of Diabetes Mellitus Treated With Traditional Chinese Medicine, alleviate the misery of the caused pruitus of diabetic.
Summary of the invention
In order to solve above-mentioned technical problem, the invention provides the Chinese medicine composition of the pruitus that a kind of instant effect, result for the treatment of is good and cure rate is high treatment diabetes cause;
The present invention also provides the preparation method of above-mentioned Chinese medicine composition.
The Chinese medicine composition of the pruitus that treatment diabetes of the present invention cause comprises the component of following portions by weight:
The Chinese medicine composition of the pruitus that preferably, treatment diabetes of the present invention cause comprises the component of following portions by weight:
Preferred, the Chinese medicine composition of the pruitus that treatment diabetes of the present invention cause comprises the component of following portions by weight:
Preferred, the Chinese medicine composition of the pruitus that treatment diabetes of the present invention cause comprises the component of following portions by weight:
The preparation method of the Chinese medicine composition of the pruitus that treatment diabetes cause, comprises following step:
Get wind-weed 5-15, Radix Angelicae Sinensis 5-15, dried rhizome of rehmannia 5-15, Radix Glycyrrhizae 5-15, motherwort 2-8, sealwort 3-10, fruit of glossy privet 2-10, radix polygonati officinalis 3-10, pseudo-ginseng 1-7, root of herbaceous peony 3-9, root of kudzu vine 1-10, rhizoma atractylodis 2-10, Radix Astragali 1-6, desmodium 2-10, potentilla discolor 5-10, the root of straight ladybell 2-8, coptis 1-6, cassia twig 2-8, semen litchi 3-10, hairyvein agrimony 2-8, Poria cocos 3-10, rhizoma alismatis 2-8 by following parts by weight, add water, decoct, at a simmer, adopt military decocting to boil, after boiling, adopt slow fire boiling 20-40 minute; Filter, retain filtrate, add water in filter residue, intense fire boils, then adds water, and after water boils, decocts 10-30 minute, merges the filtrate of twice.
Twice above-mentioned amount of water is 3-4 times of raw material dose.
Preferably, the preparation method of the Chinese medicine composition of the pruitus that treatment diabetes cause, comprises following step:
Get wind-weed 5-15, Radix Angelicae Sinensis 5-15, dried rhizome of rehmannia 5-15, Radix Glycyrrhizae 5-15, motherwort 2-8, sealwort 3-10, fruit of glossy privet 2-10, radix polygonati officinalis 3-10, pseudo-ginseng 1-7, root of herbaceous peony 3-9, root of kudzu vine 1-10, rhizoma atractylodis 2-10, Radix Astragali 1-6, desmodium 2-10, potentilla discolor 5-10, the root of straight ladybell 2-8, coptis 1-6, cassia twig 2-8, semen litchi 3-10, hairyvein agrimony 2-8, Poria cocos 3-10, rhizoma alismatis 2-8 by following parts by weight, add water, decoct, at a simmer, adopt military decocting to boil, after boiling, adopt slow fire boiling 25-35 minute; Filter, retain filtrate, add water in filter residue, intense fire boils, then adds water, and after water boils, decocts 15-25 minute, merges the filtrate of twice.
Preferably, the preparation method of the Chinese medicine composition of the pruitus that treatment diabetes cause, comprises following step:
Get wind-weed 5-15, Radix Angelicae Sinensis 5-15, dried rhizome of rehmannia 5-15, Radix Glycyrrhizae 5-15, motherwort 2-8, sealwort 3-10 fruit of glossy privet 2-10, radix polygonati officinalis 3-10, pseudo-ginseng 1-7, root of herbaceous peony 3-9, root of kudzu vine 1-10, rhizoma atractylodis 2-10, Radix Astragali 1-6, desmodium 2-10, potentilla discolor 5-10, the root of straight ladybell 2-8, coptis 1-6, cassia twig 2-8, semen litchi 3-10, hairyvein agrimony 2-8, Poria cocos 3-10, rhizoma alismatis 2-8 by following parts by weight, add water, decoct, at a simmer, adopt military decocting to boil, after boiling, adopt slow fire boiling 30 minutes; Filter, retain filtrate, add water in filter residue, intense fire boils, then adds water, and after water boils, decocts 20 minutes, merges the filtrate of twice.
Radix Angelicae Sinensis effect is all cards of the deficiency of blood; Irregular menstruation; Through closing; Dysmenorrhoea; Abdominal mass knot is poly-; Uterine bleeding; Asthenia cold abdominalgia; Impotence numbness; Numbness; Intestines are dry just difficult; Heavy after dysentery characterized by blood in the stool; Ulcer sores; Injury from falling down.
Motherwort is the herb of labiate motherwort. 1 year or biennial herb, summer-flowering. Be born in hill wasteland, ridge, meadow etc. All there is distribution most areas, the whole nation. In the time of the colored not standard-sized sheet of riotous growth in summer, pluck. Edible effect: taste is arduous, cool. Invigorate blood circulation, dispel silt, menstruation regulating, water disappears. Treatment menoxenia, threatened abortion difficult labour, placenta retension, postpartum anemic fainting, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, the carbuncle sore that swells.
The dried rhizome of rehmannia is also radix rehmanniae recen, is the piece root of scrophulariaceae rehmannia glutinosa plant, and the fresh or dry piece root of Scrophulariaceae herbaceos perennial glutinous rehmannia, is used as medicine. Main product is in China Henan, Hebei, the Inner Mongol and northeast. There is cultivation most areas. Excavate autumn, using fresh herb or dry sliced raw using. To be radix rehmanniae recen mix and steam to inside and outside local look black, glossy through adding yellow rice wine prepared rhizome of rehmannia, or directly steams to black profit and form. Cutting sheet uses. Radix rehmanniae recen has effect of clearing heat and cooling blood, beneficial Yin and promoting production of body liquid.
Rhizoma atractylodis are pungent, bitter, temperature. Return spleen, stomach, Liver Channel. Cure mainly the transporting imbalance that the spleen being blocked by dampness causes, poor appetite, vomiting is unhappy, and abdominal distension is had loose bowels, arthralgia.
The root of herbaceous peony is cool in nature, and bitter acid, is slightly cold, and has the soft liver of enriching blood, flat liver pain relieving. Astringe yin is received the effects such as sweat, is applicable to fever due to yin deficiency, irregular menstruation, chest abdomen pain over the hypochondriac region, four limbs contraction suddenly, rushes down dysentery stomachache, spontaneous sweating, uterine bleeding, is with inferior disease. That Paeoniflorin has is antibacterial, antipyretic, anti-inflammatory, increase coronary flow, improve myocardial nutritional flow, hemangiectasis, antagonism acute myocardial ischemia, suppress the effect of platelet aggregation, calmness, analgesia, spasmolysis, antiulcer, adjusting blood sugar. Root of herbaceous peony decoction can suppress shigella dysenteriae, streptococcus pneumonia, Escherichia coli, typhoid bacillus, hemolytic streptococcus, Pseudomonas aeruginosa etc.
The Radix Astragali has invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, effect of expelling pus and promoting granulation. Weak for the deficiency of vital energy, anorexia and loose stool, the sinking of qi of middle-jiao, rushes down prolapse of the anus for a long time, the uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult bursts, and bursts and does not hold back for a long time, and the deficiency of blood is sallow, and interior heat is quenched one's thirst. " herbal classic " recorded: " main ulcer, loses sore for a long time, apocenosis pain relieving. Qi-restoratives, children's's all kinds of diseases and ailments. " " Japan hanako materia medica " record: " help gas to strengthen the bone, put on flesh and enrich blood. "
Poria cocos is commonly called as Yun Ling, Song Ling, Fu spirit, and for colonizing in the fungi plant on pine roots, shape is as sweet potato, crust pitchy, the inside white or pink. Its protozoa is the dry sclerotia of On Polyporaceae Poria cocos, and multiparasitization is in the root of masson pine or Japanese red pine. Originate in the ground such as Yunnan, Anhui, Hubei, Henan, Sichuan. Ancients claim that Poria cocos is " god medicine " at 4 o'clock, because its effect is very extensive, regardless of the four seasons, by it and various compatibility of drugs, no matter cold, temperature, wind, all diseases that wets can be brought into play its unique effects. Poria cocos taste is sweet, light, property is flat, be used as medicine there is clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative, anticancer function relieves internal heat. The property of medicine is gentle, dampness removing and do not hinder healthy tendency. Take in right amount the good merchantable brand of taking good care of that can be used as spring and summer wet season. Can control that difficult urination, oedema turgor, phlegm and retained fluid are coughed contrary, contrary, the vomiting during early pregnancy of vomitting, had loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, the disease such as forgetful. Contained pachymic acid has and strengthens immunity, antitumor and calm, hypoglycemic etc. effect. The gastrointestinal smooth muscle that can relax, the effect such as gastric acid secretion inhibiting, prevents necrosis of liver cells, antibacterial. Modern medicine study: Poria cocos energy enhanced machine body immunity function, pachymaran has significantly antitumor and protect the liver dirty effect.
Pharmacology analysis: the coptis in side's medicine of the present invention has clearing heat and detoxicating effect, the fruit of Chinese magnoliavine has effect of astringent or styptic treatment for spontaneous sweating, the nourishing generate fluid of convergence, kidney calming, effect that the root of herbaceous peony has clear and coherent blood vessels, nourishing blood and liver, holds back juice in slow; The windproof Eradicates of having wind only induces sweat, removing dampness to relieve pain, effect that only convulsion is jerked surely; Radix bupleuri clearind deficient heat, above all medical instruments have that clearing heat and detoxicating, clear and coherent blood vessels, Eradicates wind are antipruritic, effect of nourishing the liver and kidney.
Beneficial effect of the present invention is, adopts above-mentioned formula and method to prepare the medicine of obtained treatment pruitus, and compound method is easy, the wide material sources of bulk drug, and also cost is lower. Follow the prescriptions principle of the traditional Chinese medical science, adopt the use that is decocted in water for oral dose, through clinical difficulty, it is evident in efficacy, reliable effect, and the property of medicine is gentle, has no side effect, efficient reaching more than 95%, cure rate reaches 75%.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.
Embodiment 1
Get the wind-weed, Radix Angelicae Sinensis, the dried rhizome of rehmannia, Radix Glycyrrhizae, motherwort, sealwort, the fruit of glossy privet, radix polygonati officinalis, pseudo-ginseng, the root of herbaceous peony, the root of kudzu vine, rhizoma atractylodis, the Radix Astragali, desmodium, potentilla discolor, the root of straight ladybell, the coptis, cassia twig, semen litchi, hairyvein agrimony, Poria cocos, rhizoma alismatis by above-mentioned parts by weight, add water, decoct, at a simmer, adopt military decocting to boil, after boiling, adopt slow fire boiling 30 minutes; Filter, retain filtrate, add water in filter residue, intense fire boils, then adds water, and after water boils, decocts 20 minutes, merges the filtrate of twice.
The clinical observation of the cutaneous pruritus that Diabetes Mellitus Treated With Traditional Chinese Medicine of the present invention causes.
Physical data
The clinical observation case pruitus patient that totally 100 routine diabetes cause, wherein male 50 examples, female's 50 examples, 20-40 age, 30 examples year, 40-50 year 30 examples,
50-60 year 30 examples, 60 years old above 10 example.
Diagnostic criteria
The back cutaneous pruritus that diabetes cause: attach most importance to night, can not fall asleep night, dry skin, scratch is obvious. Primary symptom: 1, pruitus, becoming severe at night and/or rise one after another; 2, red tongue body or partially red, tongue does or flower stripping; 3, skin is scorching hot and/or dry. Inferior disease: 1, scratch is innumerable or be lichen sample and become; 2, dysphoria with smothery sensation; 3, dry throat and mouth; 4, difficulty in defecation; 5, small and wiry pulse or string are counted accurately.
Method
1 dose of every day, sooner or later each scouring once cleaned ten minutes at every turn, and direct scouring skin after medicine heating that can be above-mentioned is cleaned skin after also above-mentioned medicine can being converted to hot water, within 15 days, is 1 course for the treatment of, 2-3 the course for the treatment of.
Efficacy assessment standard
Clinical recovery: itch disappears completely, other clinical pathology transference cures.
Effective: itch symptom disappears substantially, secondary skin obviously improves. Effective: itch alleviates, meeting inducement by chance has endurable gargalesthesia, and diseased region dwindles, and it is light red or red that skin is; Secondary skin damages and makes moderate progress. Invalid: it is not obvious that itch and secondary skin damage improvement.
Efficacy result 75 examples of fully recovering account for 75%, and effective 95 examples account for 95%, and total effective rate reaches 95%.
Embodiment 2
Get the wind-weed, Radix Angelicae Sinensis, the dried rhizome of rehmannia, Radix Glycyrrhizae, motherwort, sealwort, the fruit of glossy privet, radix polygonati officinalis, pseudo-ginseng, the root of herbaceous peony, the root of kudzu vine, rhizoma atractylodis, the Radix Astragali, desmodium, potentilla discolor, the root of straight ladybell, the coptis, cassia twig, semen litchi, hairyvein agrimony, Poria cocos, rhizoma alismatis by above-mentioned parts by weight, add water, decoct, at a simmer, adopt military decocting to boil, after boiling, adopt slow fire boiling 30 minutes; Filter, retain filtrate, add water in filter residue, intense fire boils, then adds water, and after water boils, decocts 20 minutes, merges the filtrate of twice.
Embodiment 3
Get the wind-weed, Radix Angelicae Sinensis, the dried rhizome of rehmannia, Radix Glycyrrhizae, motherwort, sealwort, the fruit of glossy privet, radix polygonati officinalis, pseudo-ginseng, the root of herbaceous peony, the root of kudzu vine, rhizoma atractylodis, the Radix Astragali, desmodium, potentilla discolor, the root of straight ladybell, the coptis, cassia twig, semen litchi, hairyvein agrimony, Poria cocos, rhizoma alismatis by above-mentioned parts by weight, add water, decoct, at a simmer, adopt military decocting to boil, after boiling, adopt slow fire boiling 20 minutes; Filter, retain filtrate, add water in filter residue, intense fire boils, then adds water, and after water boils, decocts 10 minutes, merges the filtrate of twice.
Embodiment 4
Get the wind-weed, Radix Angelicae Sinensis, the dried rhizome of rehmannia, Radix Glycyrrhizae, motherwort, sealwort, the fruit of glossy privet, radix polygonati officinalis, pseudo-ginseng, the root of herbaceous peony, the root of kudzu vine, rhizoma atractylodis, the Radix Astragali, desmodium, potentilla discolor, the root of straight ladybell, the coptis, cassia twig, semen litchi, hairyvein agrimony, Poria cocos, rhizoma alismatis by above-mentioned parts by weight, add water, decoct, at a simmer, adopt military decocting to boil, after boiling, adopt slow fire boiling 40 minutes; Filter, retain filtrate, add water in filter residue, intense fire boils, then adds water, and after water boils, decocts 10 minutes, merges the filtrate of twice.