CN108137653A - 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 - Google Patents

有抗凝血和抗血小板活性的多靶点化合物及制法和用途 Download PDF

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Publication number
CN108137653A
CN108137653A CN201580082185.8A CN201580082185A CN108137653A CN 108137653 A CN108137653 A CN 108137653A CN 201580082185 A CN201580082185 A CN 201580082185A CN 108137653 A CN108137653 A CN 108137653A
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polypeptide
gly
compound
formula
group
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CN108137653B (zh
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丁伟
范蔷薇
尹博
付国琴
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Shaanxi Micot Technology Ltd
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Shaanxi Micot Technology Ltd
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Priority to CN202110662995.8A priority Critical patent/CN113773369B/zh
Priority to CN202110662996.2A priority patent/CN113201049B/zh
Priority to CN202110661682.0A priority patent/CN113201048B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

提供了一种抗凝血和拮抗血小板GPⅡb/Ⅲa受体多靶点化合物，其通式如下：A‑L‑B‑L’‑C，其中A和B为与凝血酶结合位点，C为与血小板GPⅡb/Ⅲa受体结合位点，L为第一连接基团，L’为第二连接基团。还提供了上述化合物的制备方法及其用途。所述化合物具有体外人凝血酶抑制活性、体外血小板GPⅡb/Ⅲa受体抑制作用以及体外/体内抗血小板聚集、体内抗凝血和抗血栓作用。

Description

PCT国内申请，说明书已公开。

Claims (22)

  1. PCT国内申请，权利要求书已公开。
CN201580082185.8A 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途 Active CN108137653B (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN202110662995.8A CN113773369B (zh) 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途
CN202110662996.2A CN113201049B (zh) 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途
CN202110661682.0A CN113201048B (zh) 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2015/086173 WO2017020282A1 (zh) 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途

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CN202110662995.8A Division CN113773369B (zh) 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途
CN202110661682.0A Division CN113201048B (zh) 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途
CN202110662996.2A Division CN113201049B (zh) 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途

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CN108137653B CN108137653B (zh) 2021-07-13

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CN201580082185.8A Active CN108137653B (zh) 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途
CN202110662996.2A Active CN113201049B (zh) 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途
CN202110662995.8A Active CN113773369B (zh) 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途
CN202110661682.0A Active CN113201048B (zh) 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途

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CN202110662995.8A Active CN113773369B (zh) 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途
CN202110661682.0A Active CN113201048B (zh) 2015-08-05 2015-08-05 有抗凝血和抗血小板活性的多靶点化合物及制法和用途

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US (1) US11643439B2 (zh)
EP (1) EP3333177B1 (zh)
JP (1) JP6530564B2 (zh)
CN (4) CN108137653B (zh)
ES (1) ES2886576T3 (zh)
WO (1) WO2017020282A1 (zh)

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EP3401356A1 (en) * 2017-05-12 2018-11-14 Solvay SA Fluoropolymer hybrid composite

Citations (3)

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WO2003090733A1 (en) * 2002-04-23 2003-11-06 Vddi Pharmaceuticals Inhibition of platelet aggregation
CN1649625A (zh) * 2002-03-01 2005-08-03 图兰恩教育基金管理人 治疗剂或细胞毒性剂与生物活性肽的偶联物
WO2006102069A3 (en) * 2005-03-17 2007-02-01 Microbia Inc Methods and compositions for the treatment of hypertension and gastrointestinal disorders

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US5318899A (en) 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5196404B1 (en) * 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
GB9023149D0 (en) * 1990-10-24 1990-12-05 British Bio Technology Proteins and nucleic acids
CA2526169A1 (en) 2003-06-12 2004-12-23 Eli Lilly And Company Fusion proteins
CN1810836A (zh) * 2006-02-17 2006-08-02 北京师范大学 具有血小板GPⅡb－Ⅲa受体专一性的新型重组抗栓剂人胰岛素原－KGD嵌合肽的研制
CN101284877A (zh) * 2008-05-30 2008-10-15 重庆大学 重组靶向抗凝血酶活性和抗血小板聚集的融合蛋白及制备方法
US7803762B1 (en) 2009-08-20 2010-09-28 The Medicines Company Ready-to-use bivalirudin compositions
ES2873253T3 (es) 2010-09-28 2021-11-03 Amryt Pharmaceuticals Inc Leptinas altamente solubles
CN102241734B (zh) * 2011-04-15 2014-04-02 广东医学院 一类抗凝血多肽及其应用
CN102241735B (zh) * 2011-06-23 2014-01-22 陕西麦科奥特科技有限公司 用于预防及治疗急性冠脉综合症及抗凝抗血栓治疗的多肽及其应用
CN102702325B (zh) * 2012-06-19 2015-09-23 深圳翰宇药业股份有限公司 一种抗凝血多肽的制备方法
CN104418938B (zh) * 2013-08-28 2018-05-18 北京赛而生物药业有限公司 一种抗凝血化合物、其制备方法和用途、及包含其的药物组合物
CN104193807B (zh) * 2014-09-28 2016-06-15 广州贝奥吉因生物科技有限公司 凝血酶抑制多肽及其制备方法、应用
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WO2003090733A1 (en) * 2002-04-23 2003-11-06 Vddi Pharmaceuticals Inhibition of platelet aggregation
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Also Published As

Publication number Publication date
CN113201048B (zh) 2022-10-04
WO2017020282A1 (zh) 2017-02-09
JP2018525442A (ja) 2018-09-06
CN113201049B (zh) 2022-10-04
CN108137653B (zh) 2021-07-13
CN113773369B (zh) 2022-11-08
CN113773369A (zh) 2021-12-10
EP3333177A1 (en) 2018-06-13
EP3333177A4 (en) 2018-12-26
US11643439B2 (en) 2023-05-09
ES2886576T3 (es) 2021-12-20
JP6530564B2 (ja) 2019-06-12
CN113201049A (zh) 2021-08-03
CN113201048A (zh) 2021-08-03
US20180305409A1 (en) 2018-10-25
EP3333177B1 (en) 2021-07-14

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