CN108135737B - 用于治疗翼状胬肉的组合物和方法 - Google Patents

用于治疗翼状胬肉的组合物和方法 Download PDF

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Publication number
CN108135737B
CN108135737B CN201680042858.1A CN201680042858A CN108135737B CN 108135737 B CN108135737 B CN 108135737B CN 201680042858 A CN201680042858 A CN 201680042858A CN 108135737 B CN108135737 B CN 108135737B
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pterygium
formulation
sustained release
nintedanib
multikinase inhibitor
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CN108135737A (zh
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J.倪
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Pokvision Cloud Biomedical Technology Guangzhou Co ltd
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Poyun Biomedical Technology Guangzhou Co ltd
Cloudbreak Therapeutics LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A—HUMAN NECESSITIES
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    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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CN201680042858.1A 2015-06-06 2016-06-03 用于治疗翼状胬肉的组合物和方法 Active CN108135737B (zh)

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US201562172063P 2015-06-06 2015-06-06
US62/172,063 2015-06-06
US201562186660P 2015-06-30 2015-06-30
US62/186,660 2015-06-30
PCT/US2016/035726 WO2016200688A1 (en) 2015-06-06 2016-06-03 Compositions and methods for treating pterygium

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US (7) US9980901B2 (https=)
EP (2) EP3302379B1 (https=)
JP (5) JP6868014B2 (https=)
KR (4) KR102643821B1 (https=)
CN (2) CN108135737B (https=)
AU (3) AU2016276170B2 (https=)
ES (1) ES2971096T3 (https=)
MX (2) MX393691B (https=)
TW (1) TWI714596B (https=)
WO (1) WO2016200688A1 (https=)

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TWI700085B (zh) * 2015-06-22 2020-08-01 新源生物科技股份有限公司 酪胺酸激酶抑制劑之眼用調配物的用途
KR102657707B1 (ko) 2016-06-02 2024-04-15 에이디에스 테라퓨틱스 엘엘씨 녹내장 수술 성공을 개선하기 위해 닌테다닙을 사용하는 조성물 및 방법
US11278546B2 (en) 2016-07-22 2022-03-22 Aiviva Biopharma, Inc. Multikinase inhibitors and uses in ocular fibrosis
JP7018939B2 (ja) * 2016-09-26 2022-02-14 ルヤン （スーチョウ） バイオロジー サイエンス アンド テクノロジー カンパニー，リミテッド 眼疾患の治療のための組成物ならびに使用および調製方法
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US10335313B2 (en) * 2017-08-16 2019-07-02 Brian S. Boxer Wachler Method for removing colored spots to whiten the eye
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US10744153B1 (en) * 2019-07-01 2020-08-18 Cloudbreak Therapeutics Llc Compositions and methods for treating meibomian gland dysfunction
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WO2021165369A1 (en) * 2020-02-19 2021-08-26 Vestlandets Innovasjonsselskap As Treatment of corneal vascularisation
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JP2023527884A (ja) * 2020-06-01 2023-06-30 エーディーエス・セラピューティクス・エルエルシー 異常な血管新生を治療するための局所眼科用組成物および方法
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CN113425728A (zh) * 2021-06-29 2021-09-24 复旦大学附属眼耳鼻喉科医院 一种zd6474在翼状胬肉术后抗复发的治疗药物制备中的应用
JP2025525881A (ja) * 2022-08-16 2025-08-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 眼内使用するためのニンテダニブの医薬製剤
AU2022488910A1 (en) * 2022-12-13 2025-06-19 Suzhou Raymon Pharmaceuticals Company, Ltd. Use of naphthylurea compounds in preparation of drugs for treating pterygium
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