CN108129482A - 一种巴瑞替尼的制备方法 - Google Patents

一种巴瑞替尼的制备方法 Download PDF

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Publication number
CN108129482A
CN108129482A CN201711334329.1A CN201711334329A CN108129482A CN 108129482 A CN108129482 A CN 108129482A CN 201711334329 A CN201711334329 A CN 201711334329A CN 108129482 A CN108129482 A CN 108129482A
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CN
China
Prior art keywords
compound
reaction
buddhist nun
preparation
replaces
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201711334329.1A
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English (en)
Chinese (zh)
Inventor
徐强
吴四清
黄双
李维思
唐景玉
杨健
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Zhongbang Pharmaceutical Coltd
Original Assignee
Jiangsu Zhongbang Pharmaceutical Coltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Jiangsu Zhongbang Pharmaceutical Coltd filed Critical Jiangsu Zhongbang Pharmaceutical Coltd
Priority to CN201711334329.1A priority Critical patent/CN108129482A/zh
Publication of CN108129482A publication Critical patent/CN108129482A/zh
Priority to CN201810667443.4A priority patent/CN108586465B/zh
Priority to AU2018366342A priority patent/AU2018366342A1/en
Priority to PCT/CN2018/094160 priority patent/WO2019114258A1/fr
Priority to AU2018102141A priority patent/AU2018102141A4/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201711334329.1A 2017-12-13 2017-12-13 一种巴瑞替尼的制备方法 Withdrawn CN108129482A (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN201711334329.1A CN108129482A (zh) 2017-12-13 2017-12-13 一种巴瑞替尼的制备方法
CN201810667443.4A CN108586465B (zh) 2017-12-13 2018-06-25 一种巴瑞替尼的制备方法
AU2018366342A AU2018366342A1 (en) 2017-12-13 2018-07-03 Method for preparing Baricitinib
PCT/CN2018/094160 WO2019114258A1 (fr) 2017-12-13 2018-07-03 Procédé de préparation de baricitinib
AU2018102141A AU2018102141A4 (en) 2017-12-13 2018-07-03 Method for preparing Baricitinib

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711334329.1A CN108129482A (zh) 2017-12-13 2017-12-13 一种巴瑞替尼的制备方法

Publications (1)

Publication Number Publication Date
CN108129482A true CN108129482A (zh) 2018-06-08

Family

ID=62389618

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201711334329.1A Withdrawn CN108129482A (zh) 2017-12-13 2017-12-13 一种巴瑞替尼的制备方法
CN201810667443.4A Active CN108586465B (zh) 2017-12-13 2018-06-25 一种巴瑞替尼的制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201810667443.4A Active CN108586465B (zh) 2017-12-13 2018-06-25 一种巴瑞替尼的制备方法

Country Status (3)

Country Link
CN (2) CN108129482A (fr)
AU (2) AU2018102141A4 (fr)
WO (1) WO2019114258A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108586465A (zh) * 2017-12-13 2018-09-28 江苏中邦制药有限公司 一种巴瑞替尼的制备方法
CN111362853A (zh) * 2020-04-27 2020-07-03 安徽大学 一种3-氧杂氮杂环丁烷-1-羧酸叔丁酯的制备方法
CN112898306A (zh) * 2021-02-02 2021-06-04 山东四环药业股份有限公司 一种巴瑞替尼的制备方法
CN115124537A (zh) * 2022-07-13 2022-09-30 山东大学 一种jak抑制剂巴瑞替尼的制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021053690A1 (fr) * 2019-09-17 2021-03-25 Natco Pharma Limited Procédé amélioré pour la préparation de baricitinib

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3035395A1 (de) * 1980-09-19 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von pyrazol
ZA200905371B (en) * 2007-02-28 2010-10-27 Leo Pharma As Novel phosphodiesterase Inhibitors
DK2288610T3 (en) * 2008-03-11 2016-11-28 Incyte Holdings Corp Azetidinesulfonic AND CYCLOBUTANDERIVATER AS JAK INHIBITORS
WO2016088094A1 (fr) * 2014-12-05 2016-06-09 Sun Pharmaceutical Industries Limited Procédé de synthèse de baricitinib et d'un intermédiaire de celui-ci
US10526350B2 (en) * 2015-02-02 2020-01-07 Sun Pharmaceutical Industries Limited Process for the preparation of baricitinib and an intermediate thereof
AR104918A1 (es) * 2015-06-19 2017-08-23 Lilly Co Eli Procesos e intermediarios para la preparación de {1-(etilsulfonil)-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]azetidin-3-il}acetonitrilo
CN105294699B (zh) * 2015-12-04 2019-06-11 上海勋和医药科技有限公司 巴瑞替尼的制备方法
CN105541891B (zh) * 2016-02-04 2017-11-28 东南大学 巴瑞替尼的中间体及其制备方法及由该中间体制备巴瑞替尼的方法
CN106496195B (zh) * 2016-10-18 2019-03-08 杭州科巢生物科技有限公司 巴瑞替尼及其中间体的合成方法
CN106946917B (zh) * 2017-03-20 2019-06-11 杭州科巢生物科技有限公司 一种jak抑制剂巴瑞替尼及其中间体的新合成方法
CN107176955B (zh) * 2017-03-24 2019-04-09 南京优科制药有限公司 一种巴瑞替尼的制备方法
CN107739328B (zh) * 2017-11-22 2020-03-20 海化生命(厦门)科技有限公司 用于合成巴瑞替尼的关键中间体1的制备方法
CN108129482A (zh) * 2017-12-13 2018-06-08 江苏中邦制药有限公司 一种巴瑞替尼的制备方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108586465A (zh) * 2017-12-13 2018-09-28 江苏中邦制药有限公司 一种巴瑞替尼的制备方法
WO2019114258A1 (fr) * 2017-12-13 2019-06-20 江苏中邦制药有限公司 Procédé de préparation de baricitinib
CN111362853A (zh) * 2020-04-27 2020-07-03 安徽大学 一种3-氧杂氮杂环丁烷-1-羧酸叔丁酯的制备方法
CN112898306A (zh) * 2021-02-02 2021-06-04 山东四环药业股份有限公司 一种巴瑞替尼的制备方法
CN112898306B (zh) * 2021-02-02 2022-04-08 山东四环药业股份有限公司 一种巴瑞替尼的制备方法
CN115124537A (zh) * 2022-07-13 2022-09-30 山东大学 一种jak抑制剂巴瑞替尼的制备方法

Also Published As

Publication number Publication date
CN108586465A (zh) 2018-09-28
AU2018102141A4 (en) 2019-10-03
WO2019114258A1 (fr) 2019-06-20
CN108586465B (zh) 2020-06-02
AU2018366342A1 (en) 2019-07-04

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Application publication date: 20180608