CN108129482A - 一种巴瑞替尼的制备方法 - Google Patents

一种巴瑞替尼的制备方法 Download PDF

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Publication number
CN108129482A
CN108129482A CN201711334329.1A CN201711334329A CN108129482A CN 108129482 A CN108129482 A CN 108129482A CN 201711334329 A CN201711334329 A CN 201711334329A CN 108129482 A CN108129482 A CN 108129482A
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CN
China
Prior art keywords
compound
reaction
buddhist nun
preparation
replaces
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201711334329.1A
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English (en)
Chinese (zh)
Inventor
徐强
吴四清
黄双
李维思
唐景玉
杨健
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Zhongbang Pharmaceutical Coltd
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Jiangsu Zhongbang Pharmaceutical Coltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Jiangsu Zhongbang Pharmaceutical Coltd filed Critical Jiangsu Zhongbang Pharmaceutical Coltd
Priority to CN201711334329.1A priority Critical patent/CN108129482A/zh
Publication of CN108129482A publication Critical patent/CN108129482A/zh
Priority to CN201810667443.4A priority patent/CN108586465B/zh
Priority to PCT/CN2018/094160 priority patent/WO2019114258A1/fr
Priority to AU2018366342A priority patent/AU2018366342A1/en
Priority to AU2018102141A priority patent/AU2018102141A4/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201711334329.1A 2017-12-13 2017-12-13 一种巴瑞替尼的制备方法 Withdrawn CN108129482A (zh)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN201711334329.1A CN108129482A (zh) 2017-12-13 2017-12-13 一种巴瑞替尼的制备方法
CN201810667443.4A CN108586465B (zh) 2017-12-13 2018-06-25 一种巴瑞替尼的制备方法
PCT/CN2018/094160 WO2019114258A1 (fr) 2017-12-13 2018-07-03 Procédé de préparation de baricitinib
AU2018366342A AU2018366342A1 (en) 2017-12-13 2018-07-03 Method for preparing Baricitinib
AU2018102141A AU2018102141A4 (en) 2017-12-13 2018-07-03 Method for preparing Baricitinib

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711334329.1A CN108129482A (zh) 2017-12-13 2017-12-13 一种巴瑞替尼的制备方法

Publications (1)

Publication Number Publication Date
CN108129482A true CN108129482A (zh) 2018-06-08

Family

ID=62389618

Family Applications (2)

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CN201711334329.1A Withdrawn CN108129482A (zh) 2017-12-13 2017-12-13 一种巴瑞替尼的制备方法
CN201810667443.4A Active CN108586465B (zh) 2017-12-13 2018-06-25 一种巴瑞替尼的制备方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201810667443.4A Active CN108586465B (zh) 2017-12-13 2018-06-25 一种巴瑞替尼的制备方法

Country Status (3)

Country Link
CN (2) CN108129482A (fr)
AU (2) AU2018102141A4 (fr)
WO (1) WO2019114258A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108586465A (zh) * 2017-12-13 2018-09-28 江苏中邦制药有限公司 一种巴瑞替尼的制备方法
CN111362853A (zh) * 2020-04-27 2020-07-03 安徽大学 一种3-氧杂氮杂环丁烷-1-羧酸叔丁酯的制备方法
CN112898306A (zh) * 2021-02-02 2021-06-04 山东四环药业股份有限公司 一种巴瑞替尼的制备方法
CN115124537A (zh) * 2022-07-13 2022-09-30 山东大学 一种jak抑制剂巴瑞替尼的制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021053690A1 (fr) * 2019-09-17 2021-03-25 Natco Pharma Limited Procédé amélioré pour la préparation de baricitinib

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3035395A1 (de) * 1980-09-19 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von pyrazol
UA98639C2 (en) * 2007-02-28 2012-06-11 Лео Фарма А/С Phosphodiesterase inhibitors
JP5275371B2 (ja) * 2008-03-11 2013-08-28 インサイト・コーポレイション Ｊａｋ阻害剤としてのアゼチジン誘導体およびシクロブタン誘導体
US9873706B2 (en) * 2014-12-05 2018-01-23 Sun Pharmaceutical Industries Limited Process for the preparation of baricitinib and an intermediate thereof
US10526350B2 (en) * 2015-02-02 2020-01-07 Sun Pharmaceutical Industries Limited Process for the preparation of baricitinib and an intermediate thereof
AR104918A1 (es) * 2015-06-19 2017-08-23 Lilly Co Eli Procesos e intermediarios para la preparación de {1-(etilsulfonil)-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]azetidin-3-il}acetonitrilo
CN105294699B (zh) * 2015-12-04 2019-06-11 上海勋和医药科技有限公司 巴瑞替尼的制备方法
CN105541891B (zh) * 2016-02-04 2017-11-28 东南大学 巴瑞替尼的中间体及其制备方法及由该中间体制备巴瑞替尼的方法
CN106496195B (zh) * 2016-10-18 2019-03-08 杭州科巢生物科技有限公司 巴瑞替尼及其中间体的合成方法
CN106946917B (zh) * 2017-03-20 2019-06-11 杭州科巢生物科技有限公司 一种jak抑制剂巴瑞替尼及其中间体的新合成方法
CN107176955B (zh) * 2017-03-24 2019-04-09 南京优科制药有限公司 一种巴瑞替尼的制备方法
CN107739328B (zh) * 2017-11-22 2020-03-20 海化生命(厦门)科技有限公司 用于合成巴瑞替尼的关键中间体1的制备方法
CN108129482A (zh) * 2017-12-13 2018-06-08 江苏中邦制药有限公司 一种巴瑞替尼的制备方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108586465A (zh) * 2017-12-13 2018-09-28 江苏中邦制药有限公司 一种巴瑞替尼的制备方法
WO2019114258A1 (fr) * 2017-12-13 2019-06-20 江苏中邦制药有限公司 Procédé de préparation de baricitinib
CN111362853A (zh) * 2020-04-27 2020-07-03 安徽大学 一种3-氧杂氮杂环丁烷-1-羧酸叔丁酯的制备方法
CN112898306A (zh) * 2021-02-02 2021-06-04 山东四环药业股份有限公司 一种巴瑞替尼的制备方法
CN112898306B (zh) * 2021-02-02 2022-04-08 山东四环药业股份有限公司 一种巴瑞替尼的制备方法
CN115124537A (zh) * 2022-07-13 2022-09-30 山东大学 一种jak抑制剂巴瑞替尼的制备方法

Also Published As

Publication number Publication date
AU2018366342A1 (en) 2019-07-04
CN108586465A (zh) 2018-09-28
AU2018102141A4 (en) 2019-10-03
WO2019114258A1 (fr) 2019-06-20
CN108586465B (zh) 2020-06-02

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Application publication date: 20180608