CN108096286A - A kind of toadpoison liquid extraction process - Google Patents
A kind of toadpoison liquid extraction process Download PDFInfo
- Publication number
- CN108096286A CN108096286A CN201810160871.8A CN201810160871A CN108096286A CN 108096286 A CN108096286 A CN 108096286A CN 201810160871 A CN201810160871 A CN 201810160871A CN 108096286 A CN108096286 A CN 108096286A
- Authority
- CN
- China
- Prior art keywords
- toadpoison
- liquid
- white
- extraction process
- hot dipping
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 60
- 238000000605 extraction Methods 0.000 title claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 30
- 235000019441 ethanol Nutrition 0.000 claims abstract description 23
- 238000012545 processing Methods 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 238000007598 dipping method Methods 0.000 claims abstract description 15
- 239000000843 powder Substances 0.000 claims abstract description 10
- 239000002435 venom Substances 0.000 claims abstract description 10
- 210000001048 venom Anatomy 0.000 claims abstract description 10
- 231100000611 venom Toxicity 0.000 claims abstract description 10
- 239000008213 purified water Substances 0.000 claims abstract description 9
- 239000008215 water for injection Substances 0.000 claims abstract description 8
- 229920000742 Cotton Polymers 0.000 claims abstract description 5
- 229930006000 Sucrose Natural products 0.000 claims abstract description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 5
- 239000002775 capsule Substances 0.000 claims abstract description 5
- 238000001035 drying Methods 0.000 claims abstract description 5
- 229960004793 sucrose Drugs 0.000 claims abstract description 5
- 239000006228 supernatant Substances 0.000 claims abstract description 5
- 238000001556 precipitation Methods 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 5
- 208000030208 low-grade fever Diseases 0.000 claims description 4
- 238000001704 evaporation Methods 0.000 claims description 3
- 230000008020 evaporation Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 238000002360 preparation method Methods 0.000 abstract description 7
- 239000004480 active ingredient Substances 0.000 abstract description 6
- 239000003814 drug Substances 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 3
- 244000144974 aquaculture Species 0.000 description 2
- 238000009360 aquaculture Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003640 drug residue Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000255789 Bombyx mori Species 0.000 description 1
- 241000269417 Bufo Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000021393 food security Nutrition 0.000 description 1
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention is related to a kind of toadpoison liquid extraction process, it gathers venom including ecology, white toadpoison liquid, toadpoison hot dipping liquid and toadpoison liquid, the ecology is gathered venom squeezes toad malicious capsule in one's ear to stroke formula with hand, it is freeed after being sterilized after taking-up white liquid with cotton swab, obtain white toadpoison liquid, then the water for injection or purified water of 1~8 times of amount are added in white toadpoison liquid, hot dipping 1h~4h is kept the temperature at 60 DEG C~85 DEG C of temperature range, obtain toadpoison hot dipping liquid, then add in ethyl alcohol and carry out alcohol precipitation processing, holding time is 3~15 days, it is filtered after layering, take supernatant, as toadpoison stoste, then toadpoison stoste is carried out without alcohol processing, obtain toadpoison liquid, then toadpoison liquid is added in into cane sugar powder, drying and processing is carried out at 10 DEG C~80 DEG C, obtain toadpoison powder；Therefore, the present invention have the advantages that pure Chinese medicinal preparation, the original bioactivity of reservation and active ingredient and ratio, it is simple to operation, be more suitable for mass production.
Description
Technical field
The invention belongs to the extraction process technology fields of layer toadpoison liquid, and in particular to a kind of toadpoison liquid extraction process.
Background technology
Health, ecology, environmental protection are every profession and trade and social industry development main trend and an important canal for food security guarantee
Road, reduce medication reduce medicine it is residual be it is basic, Chinese medicine Dietotherapy health is gradually recognized, and to play traditional Chinese medicine natural to be more preferable
Component ratio characteristic, does not purify, not deep processing, simple to process liquid processed, Bufo siccus extract as no silkworm raiser's medicine, organic plantation,
The articles for use supplementary materials such as sapling maintenance, the cultivation health care of animal class；Therefore, develop a kind of pure Chinese medicinal preparation, retain original active ingredient
And ratio, toadpoison liquid extraction process simple to operation and mass production have a very important significance.
The content of the invention
The purpose of the invention is to overcome the deficiencies in the prior art, and a kind of pure Chinese medicinal preparation is provided, retains and original has
Imitate ingredient and ratio, toadpoison liquid extraction process simple to operation and mass production.
The object of the present invention is achieved like this：A kind of toadpoison liquid extraction process, it gathers venom including ecology, white toadpoison
Liquid, toadpoison hot dipping liquid and toadpoison liquid, the ecology is gathered venom squeezes toad malicious capsule in one's ear to stroke formula with hand, after taking out white liquid
Freeed after being sterilized with cotton swab, obtain white toadpoison liquid, then in white toadpoison liquid add in 1~8 times amount water for injection or
Purified water keeps the temperature hot dipping 1h~4h at 60 DEG C~85 DEG C of temperature range, obtains toadpoison hot dipping liquid, then adds in ethyl alcohol and carries out alcohol
Heavy processing, alcohol content are 40%~95%, and the holding time is 3~15 days, is filtered after layering, takes supernatant, are toadpoison stoste, so
Afterwards toadpoison stoste without alcohol processing, obtain toadpoison liquid, toadpoison liquid then is added in cane sugar powder, is carried out at 10 DEG C~80 DEG C
Drying and processing obtains toadpoison powder.
The water for injection or purified water are to select one of which.
The toadpoison stoste is faint yellow or rufous.
The method of the no alcohol processing is evaporated to stand volatilization or low-grade fever.
Beneficial effects of the present invention：The present invention carries out fanout free region processing to toad, and sustainability is strong；It is simple to operation, it fits
Mass production is closed, is added without any chemical components, pure Chinese medicinal preparation, the more original active ingredient of reservation and ratio, raw as far as possible
State no drug residue, it is naturally, without side-effects, develop aquaculture, animal husbandry is promoted to develop in a healthy way, bioactivity is high, availability height etc.；Cause
This, the present invention has the advantages that pure Chinese medicinal preparation, retains original active ingredient and ratio, simple to operation and mass production.
Specific embodiment
Embodiment 1
A kind of toadpoison liquid extraction process, it gathers venom including ecology, white toadpoison liquid, toadpoison hot dipping liquid and toadpoison liquid, the ecology
It gathers venom and squeezes toad malicious capsule in one's ear to stroke formula with hand, freeed after being sterilized after taking-up white liquid with cotton swab, obtain white toadpoison
Then liquid adds in the water for injection or purified water of 1~8 times of amount, at 60 DEG C~85 DEG C of temperature range in white toadpoison liquid
Hot dipping 1h~4h is kept the temperature, obtains toadpoison hot dipping liquid, ethyl alcohol is then added in and carries out alcohol precipitation processing, alcohol content is 40%~95%, is preserved
Time is 3~15 days, is filtered after layering, takes supernatant, is toadpoison stoste, then by toadpoison stoste without alcohol processing, obtain
To toadpoison liquid, toadpoison liquid is then added in into cane sugar powder, drying and processing is carried out at 10 DEG C~80 DEG C, obtains toadpoison powder.
The present invention carries out fanout free region processing to toad, and sustainability is strong；It is simple to operation, it is suitble to mass production, is added without
Any chemical components, pure Chinese medicinal preparation, the try one's best more original active ingredient of reservation and ratio, ecological no drug residue, naturally, no pair
Effect develops aquaculture, and animal husbandry is promoted to develop in a healthy way, and bioactivity is high, availability height etc.；Specifically for water for injection or
For purified water to select one of which, toadpoison stoste is rufous, and the method for no alcohol processing is standing volatilization or low-grade fever evaporation；
Therefore, the present invention has the advantages that pure Chinese medicinal preparation, retains original active ingredient and ratio, simple to operation and mass production.
Embodiment 2
A kind of toadpoison liquid extraction process, it gathers venom including ecology, white toadpoison liquid, toadpoison hot dipping liquid and toadpoison liquid, the ecology
It gathers venom and squeezes toad malicious capsule in one's ear to stroke formula with hand, freeed after being sterilized after taking-up white liquid with cotton swab, obtain white toadpoison
Then liquid adds in the water for injection or purified water of 1~8 times of amount, at 60 DEG C~85 DEG C of temperature range in white toadpoison liquid
Hot dipping 1h~4h is kept the temperature, obtains toadpoison hot dipping liquid, ethyl alcohol is then added in and carries out alcohol precipitation processing, alcohol content is 40%~95%, is preserved
Time is 3~15 days, is filtered after layering, takes supernatant, is toadpoison stoste, then by toadpoison stoste without alcohol processing, obtain
To toadpoison liquid, toadpoison liquid is then added in into cane sugar powder, drying and processing is carried out at 10 DEG C~80 DEG C, obtains toadpoison powder, the note
It is to select one of which to penetrate with water or purified water, and the toadpoison stoste is faint yellow or rufous, the method for the no alcohol processing
To stand volatilization or low-grade fever evaporation.
Specific embodiment is unrestricted to further explanation of the invention, is existed for those of ordinary skills
Further conversion is done in the case of not departing from substantive content of the present invention to structure, and all these conversion should all belong to institute of the present invention
Attached scope of the claims.
Claims (4)
1. a kind of toadpoison liquid extraction process, it gathers venom including ecology, white toadpoison liquid, toadpoison hot dipping liquid and toadpoison liquid, feature
It is：The ecology is gathered venom squeezes toad malicious capsule in one's ear to stroke formula with hand, is freeed after being sterilized after taking-up white liquid with cotton swab,
White toadpoison liquid is obtained, the water for injection or purified water of 1~8 times of amount are then added in white toadpoison liquid, in temperature range
Hot dipping 1h~4h is kept the temperature at 60 DEG C~85 DEG C, obtains toadpoison hot dipping liquid, ethyl alcohol is then added in and carries out alcohol precipitation processing, alcohol content is
40%~95%, the holding time be 3~15 days, filtered after layering, take supernatant, be toadpoison stoste, then by toadpoison stoste into
Row obtains toadpoison liquid, toadpoison liquid then is added in cane sugar powder, in 10 DEG C~80 DEG C downlink drying and processings, obtains toad without alcohol processing
Malicious powder.
2. a kind of toadpoison liquid extraction process according to claim 1, it is characterised in that：The water for injection or purified water
To select one of which.
3. a kind of toadpoison liquid extraction process according to claim 1, it is characterised in that：The toadpoison stoste is faint yellow
Or rufous.
4. a kind of toadpoison liquid extraction process according to claim 1, it is characterised in that：The method of the Ethanol Treatment is quiet
Put, volatilize or low-grade fever evaporation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810160871.8A CN108096286A (en) | 2018-02-27 | 2018-02-27 | A kind of toadpoison liquid extraction process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810160871.8A CN108096286A (en) | 2018-02-27 | 2018-02-27 | A kind of toadpoison liquid extraction process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108096286A true CN108096286A (en) | 2018-06-01 |
Family
ID=62205578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810160871.8A Pending CN108096286A (en) | 2018-02-27 | 2018-02-27 | A kind of toadpoison liquid extraction process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108096286A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101176739A (en) * | 2006-11-08 | 2008-05-14 | 山东绿叶制药有限公司 | Toadpoison ligand extract as well as preparation method and application thereof |
| US20100158900A1 (en) * | 2005-06-27 | 2010-06-24 | Alexei Bagrov | Anti-marinobufagenin antibodies and methods for their use |
| CN104997759A (en) * | 2015-07-14 | 2015-10-28 | 合肥华方医药科技有限公司 | Total bufadienolides solid lipid nanoparticle drug delivery system for injection and preparation method thereof |
| US20150328234A1 (en) * | 2012-12-26 | 2015-11-19 | The Fourth Military Medical University | Bufalin liposome, preparation method therefor and application thereof |
| CN107233348A (en) * | 2017-05-31 | 2017-10-10 | 宁夏医科大学 | A kind of bufotalin nanocrystal and preparation method thereof |
| CN107320501A (en) * | 2017-08-04 | 2017-11-07 | 黄娇英 | A kind of toad cake extract with antitumaous effect and preparation method thereof |
| CN107397748A (en) * | 2017-08-09 | 2017-11-28 | 黄娇英 | A kind of toad cake extract with anti-infectious function and preparation method thereof |
-
2018
- 2018-02-27 CN CN201810160871.8A patent/CN108096286A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100158900A1 (en) * | 2005-06-27 | 2010-06-24 | Alexei Bagrov | Anti-marinobufagenin antibodies and methods for their use |
| CN101176739A (en) * | 2006-11-08 | 2008-05-14 | 山东绿叶制药有限公司 | Toadpoison ligand extract as well as preparation method and application thereof |
| US20150328234A1 (en) * | 2012-12-26 | 2015-11-19 | The Fourth Military Medical University | Bufalin liposome, preparation method therefor and application thereof |
| CN104997759A (en) * | 2015-07-14 | 2015-10-28 | 合肥华方医药科技有限公司 | Total bufadienolides solid lipid nanoparticle drug delivery system for injection and preparation method thereof |
| CN107233348A (en) * | 2017-05-31 | 2017-10-10 | 宁夏医科大学 | A kind of bufotalin nanocrystal and preparation method thereof |
| CN107320501A (en) * | 2017-08-04 | 2017-11-07 | 黄娇英 | A kind of toad cake extract with antitumaous effect and preparation method thereof |
| CN107397748A (en) * | 2017-08-09 | 2017-11-28 | 黄娇英 | A kind of toad cake extract with anti-infectious function and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 张素娟等: "蟾酥提取工艺优化与提取物外抗肿瘤活性研究", 《上海中医药杂志》 * |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180601 |