CN108079036A - The preparation method of achene of Siberian cocklebur nasal drops - Google Patents
The preparation method of achene of Siberian cocklebur nasal drops Download PDFInfo
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- CN108079036A CN108079036A CN201711303140.6A CN201711303140A CN108079036A CN 108079036 A CN108079036 A CN 108079036A CN 201711303140 A CN201711303140 A CN 201711303140A CN 108079036 A CN108079036 A CN 108079036A
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- Prior art keywords
- siberian cocklebur
- achene
- nasal drops
- method described
- oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/17—Preparation or pretreatment of starting material involving drying, e.g. sun-drying or wilting
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
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Abstract
The present invention relates to the preparation methods of achene of Siberian cocklebur nasal drops, the described method comprises the following steps：（1）The achene of Siberian cocklebur is cleaned, is dried；（2）The dry achene of Siberian cocklebur is put into frying pan and is stir-fried, crushes simultaneously grind into powder；（3）Siberian Cocklebur Fruit is added in alcoholic solvent, is ultrasonically treated, is filtered and concentrate filtrate；（4）Concentrate is added in vegetable oil, heating stirring, sterilized, cooled down, encapsulation obtains achene of Siberian cocklebur nasal drops.The invention further relates to the achene of Siberian cocklebur nasal drops obtained by above-mentioned preparation method.The present invention improves the preparation process of achene of Siberian cocklebur nasal drops, substitutes manual preparation method, is more suitable for mass producing, and is used as medicine using single medicine, and compatibility is simple, easily controllable, and safety coefficient is high, and production cost is low, easy to use.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to the preparation method of achene of Siberian cocklebur nasal drops.
Background technology
Achene of Siberian cocklebur alias：Lice head of the horse, stout pale, the road number of people, eight naked, grey prodigals of thorn, continuous grey prodigal, the naked son of Qiang's, blue or green spine
Son robs son, silly head mother-in-law, and Hu Cangzi, wild eggplant, pig ear, dish ear belong to composite family, Xanthium, the band of annual herb feverfew Siberian cocklebur
The fruit of involucre, the achene of Siberian cocklebur belong to common Chinese herbal medicine, have that relieve heat dehumidifying is sensible and other effects, often with the dispersing wind and colds such as the flower bud of lily magnolia, the root of Dahurain angelica,
Clearing the nasal passage compatibility of drugs, for the treatment of rhinitis.
During for preventing or treat rhinitis, after often the achene of Siberian cocklebur is smashed to pieces by hand, sesame oil is added in, is simmered in water out, draw medicine
Oil is applied to nasal cavity after being picked with cotton swab, although the medicine oil so prepared by hand is effective, this medicine oil is not easy to store, and easily grows
Endophytic bacteria and go bad, and now-making-now-using, use are more inconvenient.It on the other hand, can not be by Siberian cocklebur only with sesame oil digestion
The active material extraction of son is abundant, influences drug effect.
The content of the invention
In order to solve the above technical problems, inventor to the preparation process of achene of Siberian cocklebur nasal drops investigate and optimize comprehensively,
It proposes that one kind can mass produce, ensures the preparation method of drug effect, thereby completing the present invention.
Therefore, present invention firstly provides the preparation method of achene of Siberian cocklebur nasal drops, the described method comprises the following steps：
（1）After the achene of Siberian cocklebur is cleaned, it is dried in drying box；
（2）The dry achene of Siberian cocklebur is put into frying pan the 10-15min that stir-fries, except deburring, crushes simultaneously grind into powder；
（3）Siberian Cocklebur Fruit is added in alcoholic solvent, is ultrasonically treated more than 20min, filtering concentrates filtrate, obtains grease；
（4）Grease is added in vegetable oil, the heating stirring 20min at 50-60 DEG C, sterilized, cooled down, encapsulation obtains Siberian cocklebur
Sub- nasal drops.
Wherein, step（1）Middle drying box is arranged to 100-105 DEG C, and dry to be no more than 8min, otherwise active material is easy to brokenly
It is bad.
Step（2）In, stir-frying is to take out to surface buff in frying pan, it is impossible to which stir-fry overlong time, i.e., cannot smell
Burning.Powder crosses 30 mesh sieves after grinding.
Step（3）In, the alcoholic solvent includes methanol, ethyl alcohol, isopropanol, propylene glycol, promotes activity using being ultrasonically treated
Substance dissolves, and 20-25min is preferably ultrasonically treated, with energy saving.After filtering, filtrate is condensed into pale yellow oil, until without alcohol
Taste.
Step（4）In, the vegetable oil includes sesame oil, olive oil, tea oil, castor oil, rapeseed oil etc., grease and plant
The weight ratio of oil is 1:0.8~1.5.If necessary, preservative, such as vitamin E etc. can be also added in vegetable oil.
The sterilizing is high-temp steam sterilizing, and sterilize 20min in 110 DEG C of steam streams.
In addition, the present invention also provides the achene of Siberian cocklebur nasal drops obtained by above-mentioned preparation method.The achene of Siberian cocklebur drop of the present invention
Nose liquid is not under the conditions of breaking a seal, and the shelf-life was up to 2 years.It need to be in two months using finishing behind Kaifeng.
When for preventing or treating rhinitis, pick a small amount of achene of Siberian cocklebur nasal drops with swab stick and be applied in nasal cavity, Huo Zhezhi
It connects and instills nasal cavity with dropper, you can alleviate Rhinitis Symptoms, adhere to that use can inhibit clinical episodes.
The present invention improves the preparation process of achene of Siberian cocklebur nasal drops, substitutes manual preparation method, is more suitable for extensive life
Production, and be used as medicine using single medicine, compatibility is simple, easily controllable, and safety coefficient is high, and production cost is low, easy to use, is suitable for
Long-time service.
Specific embodiment
The present invention is further described with reference to specific embodiment.
Embodiment 1
Achene of Siberian cocklebur nasal drops is prepared using following methods：
（1）It after about 50 achenes of Siberian cocklebur are cleaned, is placed in drying box, drying box is arranged to 100-105 DEG C, dry about 7min；
（2）The dry achene of Siberian cocklebur is put into frying pan the 10min that stir-fries, until surface buff takes out, except deburring, crushes and grinds
Into powder, 30 mesh sieves are crossed；
（3）20g Siberian Cocklebur Fruits are added in 50mL absolute ethyl alcohols, are ultrasonically treated 20min in ultrasound room, filtering is dense by filtrate
No alcohol taste is reduced to, obtains about 15g grease；
（4）15g grease is added in 15g sesame oil, the heating stirring 20min at 55 DEG C sterilizes in 110 DEG C of steam streams
20min is cooled down, and encapsulation obtains achene of Siberian cocklebur nasal drops.
Embodiment 2
Achene of Siberian cocklebur nasal drops is prepared using following methods：
（1）It after about 50 achenes of Siberian cocklebur are cleaned, is placed in drying box, drying box is arranged to 100-105 DEG C, dry about 5min；
（2）The dry achene of Siberian cocklebur is put into frying pan the 15min that stir-fries, until surface buff takes out, except deburring, crushes and grinds
Into powder, 30 mesh sieves are crossed；
（3）20g Siberian Cocklebur Fruits are added in 50mL isopropanols, are ultrasonically treated 25min in ultrasound room, filtering concentrates filtrate
To no alcohol taste, about 12g grease is obtained；
（4）12g grease is added in 18g olive oil, the heating stirring 20min at 60 DEG C sterilizes in 110 DEG C of steam streams
20min is cooled down, and encapsulation obtains achene of Siberian cocklebur nasal drops.
It is tried out in about 200 patients with rhinitis, it is efficient up to 86%（Rhinitis Symptoms alleviation is considered as effectively）, 13 patient's heavily fortified points
It holds using 1 year or more, Rhinitis Symptoms no longer recur.
Above only describes the better embodiment of the present invention, but the present invention is not limited to above-described embodiments.This field skill
Art personnel should all fall into the present invention it is understood that any same or similar means of the technology of the present invention effect can be realized
Protection domain in.
Claims (9)
1. the preparation method of achene of Siberian cocklebur nasal drops, the described method comprises the following steps：
（1）After the achene of Siberian cocklebur is cleaned, it is dried in drying box；
（2）The dry achene of Siberian cocklebur is put into frying pan the 10-15min that stir-fries, except deburring, crushes simultaneously grind into powder；
（3）Siberian Cocklebur Fruit is added in alcoholic solvent, is ultrasonically treated more than 20min, filtering concentrates filtrate, obtains grease；
（4）Grease is added in vegetable oil, the heating stirring 20min at 50-60 DEG C, sterilized, cooled down, encapsulation obtains Siberian cocklebur
Sub- nasal drops.
2. according to the method described in claim 1, it is characterized in that, step（1）Middle drying box is arranged to 100-105 DEG C, drying
No more than 8min.
3. according to the method described in claim 1, it is characterized in that, step（2）In, stir-frying to surface buff is in frying pan
It takes out, powder crosses 30 mesh sieves after grinding.
4. according to the method described in claim 1, it is characterized in that, step（3）In, the alcoholic solvent includes methanol, ethyl alcohol, different
Propyl alcohol, propylene glycol.
5. according to the method described in claim 1, it is characterized in that, step（3）In, it is ultrasonically treated 20-25min.
6. according to the method described in claim 1, it is characterized in that, step（4）In, the vegetable oil include sesame oil, olive oil,
The weight ratio of tea oil, castor oil, rapeseed oil, the grease and the vegetable oil is 1:0.8~1.5.
7. according to the method described in claim 1, it is characterized in that, step（4）In, also anti-corrosion is added in into the vegetable oil
Agent.
8. according to the method described in claim 1, it is characterized in that, step（4）In, the sterilizing is high-temp steam sterilizing,
Sterilize 20min in 110 DEG C of steam streams.
9. the achene of Siberian cocklebur nasal drops prepared as the method any one of claim 1-8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711303140.6A CN108079036A (en) | 2017-12-11 | 2017-12-11 | The preparation method of achene of Siberian cocklebur nasal drops |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711303140.6A CN108079036A (en) | 2017-12-11 | 2017-12-11 | The preparation method of achene of Siberian cocklebur nasal drops |
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| Publication Number | Publication Date |
|---|---|
| CN108079036A true CN108079036A (en) | 2018-05-29 |
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ID=62174137
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711303140.6A Withdrawn CN108079036A (en) | 2017-12-11 | 2017-12-11 | The preparation method of achene of Siberian cocklebur nasal drops |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112915153A (en) * | 2021-03-12 | 2021-06-08 | 南京康天生物科技有限公司 | Rhinitis drop for relieving nasal obstruction and preparation method thereof |
-
2017
- 2017-12-11 CN CN201711303140.6A patent/CN108079036A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112915153A (en) * | 2021-03-12 | 2021-06-08 | 南京康天生物科技有限公司 | Rhinitis drop for relieving nasal obstruction and preparation method thereof |
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Application publication date: 20180529 |
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| WW01 | Invention patent application withdrawn after publication |