CN112915153A - Rhinitis drop for relieving nasal obstruction and preparation method thereof - Google Patents
Rhinitis drop for relieving nasal obstruction and preparation method thereof Download PDFInfo
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The rhinitis drop for relieving nasal obstruction is prepared from the following raw materials in parts by weight: 35-40 parts of cocklebur fruit oil, 40-45 parts of magnolia flower volatile oil, 15-20 parts of rhizoma paridis extract, 5-10 parts of rhizoma acori graminei extract, 5-8 parts of radix angelicae extract and 0.5-1 part of dementholized peppermint oil; the rhinitis drop is prepared from all natural medicines, has no toxic or side effect and dependence, and has the effects of broad-spectrum sterilization, inflammation diminishing, virus resistance, nasal mucosa protection, nasal mucosa nutrition, immunity enhancement, microcirculation improvement and damaged tissue repair promotion through clinical verification; and has the advantages of convenient use, high cure rate and difficult recurrence.
Description
[ technical field ] A method for producing a semiconductor device
The invention relates to the field of Chinese patent medicines, in particular to rhinitis drops for relieving nasal obstruction and a preparation method thereof.
[ background of the invention ]
Nasal inflammation refers to inflammation of the nasal mucosa and submucosal tissue. Nasal inflammation is manifested as congestion or edema, and patients often have symptoms of nasal obstruction, clear watery nasal discharge, nasal itching, throat discomfort and cough. The nasal inflammation cannot be treated in time, not only affects the smell of a patient and the physiological function of a nasal cavity, but also spreads to adjacent organs or tissues, so that the patient is more uncomfortable, and the life and the work of the patient are seriously affected.
At present, a lot of medicines for treating acute rhinitis and chronic allergic rhinitis are available, the common medicines mainly comprise oral administration criminals, and the medicines for oral administration can reach the nose due to the fact that the medicines need to be sent to nasal mucosa through systemic circulation and the like, so that the medicine has the defects of slow effect taking and small drug effect. In addition, in modern clinical treatment, allergic rhinitis and chronic rhinitis are mostly applied to oral medicaments such as diji, Biyankang, nasosinusitis oral liquid, Youguan, Raynaudite and the like, and the medicaments have the disadvantages of large side effect, long administration time, high recurrence rate after stopping administration and incapability of radically treating.
Therefore, the problem to be solved in the field is to provide the rhinitis drop for relieving nasal obstruction and the preparation method thereof.
[ summary of the invention ]
Aiming at the problems, the rhinitis drop is prepared from all natural medicines, has no toxic or side effect and dependence, and has the effects of broad-spectrum sterilization, inflammation diminishing, virus resistance, nasal mucosa protection, nasal mucosa nutrition, immunity enhancement, microcirculation improvement and damaged tissue repair promotion through clinical verification; and has the advantages of convenient use, high cure rate and difficult recurrence.
In order to solve the problems, the invention provides a rhinitis drop for relieving nasal obstruction, which is prepared from the following raw materials in parts by weight: 35-40 parts of cocklebur fruit oil, 40-45 parts of magnolia flower volatile oil, 15-20 parts of rhizoma paridis extract, 5-10 parts of rhizoma acori graminei extract, 5-8 parts of radix angelicae extract and 0.5-1 part of dementholized peppermint oil.
Further, the rhinitis drop is prepared from the following raw materials in parts by weight: 38 parts of xanthium sibiricum oil, 42 parts of magnolia flower volatile oil, 18 parts of rhizoma paridis extract, 7 parts of rhizoma acori graminei extract, 6 parts of angelica dahurica extract and 0.8 part of dementholized peppermint oil.
The manufacturing method comprises the following steps:
the method comprises the following steps: cleaning fructus Xanthii, drying, parching, removing thorns, pulverizing, grinding into powder, adding into alcohol solvent, ultrasonic treating, filtering, concentrating the filtrate to obtain oily substance, adding the oily substance into vegetable oil, heating under stirring, sterilizing, cooling, and packaging to obtain fructus Xanthii oil.
Step two: drying and pulverizing flos Magnoliae fruit, adding 60% ethanol solution 5 times of flos Magnoliae fruit, extracting with ultrasonic wave, filtering, and concentrating the filtrate until there is no alcohol smell; eluting the obtained concentrated solution with 60% chloroform, collecting eluate, concentrating, and drying to obtain volatile oil.
Step three: extracting dried rhizoma paridis with 55% ethanol under reflux, and mixing extractive solutions.
Step four: adding 10 times of water into rhizoma Acori Graminei, extracting at 95 deg.C for 4 times, filtering, concentrating under reduced pressure, adding ethanol, settling, collecting supernatant, adsorbing with resin and active carbon, eluting with ionized water and ethanol, collecting eluate, and concentrating under reduced pressure.
Step five: crushing the angelica dahurica into coarse powder, adding 75% ethanol, heating and soaking for 3 hours, heating again, starting reflux extraction to obtain an extracting solution, and conveying the extracting solution to a liquid medicine storage tank; adding 75% ethanol into the extraction tank, soaking at normal temperature, heating, refluxing, extracting to obtain extractive solution, transferring the extractive solution to a medicinal liquid storage tank, and mixing the extractive solutions; pumping the extractive solution in the medicinal liquid storage tank into a reduced pressure concentration tank for concentrating and extracting.
Further, in the first step, the drying temperature is 100 ℃ and the drying time is 5-10min at 110 ℃.
Furthermore, in the fourth step, the dosage of the active carbon is 1mL of active carbon/1 g of rhizoma acori graminei medicinal material.
Further, in the fifth step, the heating temperature is 75-78 ℃, the steam pressure for concentration and extraction is less than or equal to 0.1Mpa, the vacuum degree is 0.06-0.08Mpa, and the concentration temperature is 40-80 ℃.
Furthermore, the rhinitis drop is prepared from all natural medicines, has no toxic or side effect and dependence, and has the effects of broad-spectrum sterilization, inflammation diminishing, virus resisting, nasal mucosa protecting, nasal mucosa nourishing, immunity enhancing, microcirculation improving and damaged tissue repairing through clinical verification.
[ detailed description ] embodiments
The invention discloses a method for preparing rhinitis drops for relieving nasal obstruction, and a person skilled in the art can realize the method by properly improving process parameters by taking the contents of the invention as reference. It is expressly intended that all such similar substitutes and modifications which would be obvious to those skilled in the art are deemed to be included in the invention. While the method and application of the present invention have been described in terms of preferred embodiments, it will be apparent to those of ordinary skill in the art that variations and modifications in the method and application described herein may be made and equivalents employed without departing from the spirit and scope of the invention.
For a further understanding of the present invention, reference will now be made in detail to the following examples.
The rhinitis drop for relieving nasal obstruction is prepared from the following raw materials in parts by weight: 35-40 parts of cocklebur fruit oil, 40-45 parts of magnolia flower volatile oil, 15-20 parts of rhizoma paridis extract, 5-10 parts of rhizoma acori graminei extract, 5-8 parts of radix angelicae extract and 0.5-1 part of dementholized peppermint oil;
preferably, the rhinitis drop is prepared from the following raw materials in parts by weight: 38 parts of xanthium sibiricum oil, 42 parts of magnolia flower volatile oil, 18 parts of rhizoma paridis extract, 7 parts of rhizoma acori graminei extract, 6 parts of angelica dahurica extract and 0.8 part of dementholized peppermint oil;
fructus xanthil: ripe fruit with involucre of Xanthium strumarium of Compositae, pungent, bitter and warm in taste; enters lung meridian, has the effects of dispersing wind cold, dredging nasal orifice, dispelling wind-damp and relieving pain, and is mainly used for treating wind cold exterior syndrome such as acute sinusitis, chronic sinusitis, acute rhinitis, chronic rhinitis, allergic rhinitis and the like.
And (3) magnolia flower: flos Magnoliae of Magnoliaceae and Magnoliaceae, flos Magnoliae or flower bud of Magnolia wushurica contains volatile oil, oil contains flos Magnoliae essence, alpha-spinacene, eucalyptol, alkaloid, and lignan; the bud of the magnolia contains volatile oil, and the oil contains citral, eugenol, eucalyptol, alkaloid and the like. The Wudangyulan flower bud contains volatile oil, Magnolia salicina, Wudangyulan magnolia alkali, etc. Has effects of dispelling pathogenic wind and cold, and relieving stuffy nose. It can be used for treating wind-cold type common cold, nasal obstruction, and nasosinusitis.
Rhizoma paridis: dried rhizome of Paris polyphylla or Paris polyphylla of Liliaceae contains pariphyllin, dioscin, tannic acid and 18 kinds of amino acids, creatinine, alkaloid, flavone, sterone, ecdysone, daucosterol, etc., and has effects of clearing away heat and toxic materials, relieving swelling and pain, cooling liver, and arresting convulsion. It can be used for treating carbuncle, furuncle, sore throat, venomous snake bite, convulsion, and traumatic injury.
Grassleaf sweelflag rhizome: dried rhizome of Acorus tatarinowii Schott of Acorus of Araceae contains volatile oil 0.11% -0.42%, wherein the volatile oil mainly comprises beta-asarone, alpha-asarone, caryophyllene, alpha-humulene, acorus gramineus ether, asarone, etc., and also contains amino acid, organic acid and saccharide, and has effects of inducing resuscitation, eliminating dampness, regulating stomach, tranquilizing mind and benefiting mind. It is indicated for phlegm clouding the clear orifices and coma.
Radix angelicae: the root of Angelica dahurica and Angelica dahurica of Angelica of Umbelliferae contains volatile oil, and contains various coumarin compounds such as imperatorin and Angelica dahurica, and contains radix Angelicae Dahuricae toxin, xanthotoxol, sterol, stearic acid, etc., and has effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, stopping leukorrhagia, relieving swelling, promoting pus discharge, dispelling pathogenic wind and relieving itching. It can be used for treating wind-cold type common cold, headache, toothache, arthralgia, nasosinusitis, skin sore, carbuncle, skin pruritus, etc.
Mint: the aerial parts of Mentha haplocalyx of Mentha of Labiatae contains volatile oil, and the main ingredient of the oil is menthol, menthone, isomenthone, menthol, menthyl esters, etc. In addition, it contains isopetallic leaf extract, peppermint glucoside and several free amino acids. Has effects of dispelling pathogenic wind and heat, clearing head and eyes, relieving sore throat, promoting eruption, dispersing stagnated liver qi, and activating qi-flowing. Can be used for treating wind-heat type common cold, early stage epidemic febrile disease, wind-heat type headache, conjunctival congestion, lacrimation, sore throat, measles without adequate eruption, pruritus, stagnation of qi due to depression of liver, chest distress, and hypochondriac pain.
The preparation method of the rhinitis drop comprises the following steps:
the method comprises the following steps: extracting Xanthium sibiricum oil
(1) Cleaning fructus Xanthii, and drying in a drying oven at 100 deg.C and 110 deg.C for 5-10 min;
(2) parching fructus Xanthii in a pan for 10-15min, removing thorns, pulverizing and grinding into powder, and sieving with 30 mesh sieve;
(3) adding fructus Xanthii powder into alcohol solvent, ultrasonic treating for 20-25min, filtering, and concentrating the filtrate to obtain oily substance;
(4) adding the oily substance into vegetable oil such as oleum Rapae and oleum Olivarum, heating and stirring at 50-60 deg.C for 20min, sterilizing, cooling, and packaging to obtain Xanthii oil.
Step two: extracting volatile oil of flos Magnoliae
Drying and crushing magnolia flower fruits, and sieving the crushed magnolia flower fruits by a 40-mesh sieve; adding 60% ethanol solution 5 times the weight of the raw materials, extracting with 60KHz ultrasonic wave, filtering, and concentrating the filtrate until no alcohol smell is present; loading the obtained concentrated solution onto macroporous adsorbent resin XDA-1, eluting with 4 times of column volume of 60% chloroform, collecting eluate, concentrating, and drying to obtain volatile oil with extraction rate of 71.84%.
Step three: preparation of Paris polyphylla extract
Extracting dried rhizoma paridis with 55% ethanol under reflux, mixing extractive solutions, and concentrating to obtain ethanol extract concentrate; diluting the obtained ethanol extract concentrate with water, sequentially extracting with petroleum ether, ethyl acetate and water saturated n-butanol, and concentrating under reduced pressure to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; dissolving n-butanol extract with water, filtering, enriching active components with macroporous resin, washing with 10% ethanol for 8 column volumes to remove large polar components, eluting with 70% ethanol for 12 column volumes, collecting 70% eluate, and concentrating under reduced pressure.
Step four: preparation of Acorus tatarinowii Schott extract
Adding 10 times of water into a calamus medicinal material, extracting for 0.5 hour at 95 ℃, extracting for 4 times, filtering, concentrating under reduced pressure at 60 ℃ to 2mL/1g of medicinal material, adding 95% ethanol until the ethanol concentration is 65%, settling for 12 hours, centrifuging to obtain a supernatant, concentrating until no alcohol smell exists, centrifuging to obtain a supernatant, concentrating until the supernatant is dry, adding water to dissolve, feeding the solution onto D101 macroporous adsorption resin, wherein the resin is 1mL of resin/1 g of rhizoma acori graminei medicinal material, the column diameter height ratio is 1:4, the sampling flow rate is 2.0BV/h, eluting a resin column with 4BV of deionized water after sampling is finished, collecting water eluent, concentrating under reduced pressure at 60 ℃, cooling, and then feeding active carbon, wherein the active carbon is 1mL of active carbon/1 g of rhizoma acori graminei medicinal material, the column diameter height ratio is 1:4, and the sampling flow rate is 2.0 BV/h. After the sample loading is finished, eluting the activated carbon column by using 3BV of deionized water, discarding the water eluent, eluting the activated carbon column by using 3BV of 30% ethanol, collecting the 30% ethanol eluent, and concentrating under reduced pressure at 60 ℃.
Step five: preparation of Angelica dahurica extract
Sorting out impurities and non-medicinal parts in the angelica dahurica medicinal material and discarding the impurities and the non-medicinal parts; crushing the selected angelica dahurica medicinal material into coarse powder; adding radix Angelicae Dahuricae coarse powder into an extraction tank, adding 75% ethanol into the extraction tank, heating to 60 deg.C, soaking for 1-1.5 hr, stopping heating, soaking for 3 hr, heating again to 75-78 deg.C, timing, reflux extracting for 1 hr to obtain extractive solution, and transferring the extractive solution to a medicinal liquid storage tank; adding 75% ethanol into the extraction tank, soaking at normal temperature for 1 hr, heating again at 75-78 deg.C, timing, reflux extracting for 1 hr to obtain extractive solution, transferring the extractive solution to a medicinal liquid storage tank, and mixing the extractive solutions; pumping the extractive solution in the medicinal liquid storage tank into a reduced pressure concentration tank for concentrating and extracting (heating steam pressure is less than or equal to 0.1Mpa, vacuum degree is 0.06-0.08Mpa, and concentration temperature is 40-80 deg.C); the angelica extract is produced when the relative density reaches 1.10-1.40.
Step six: extracting peppermint oil extract
Liquefying the raw materials in a drying room, and controlling the temperature in the drying room to be 60-70 ℃ to form mint raw oil; the liquefied mint raw oil is put into a dehydration tank, dehydration is carried out until the dehydration is lower than 0.03%, the temperature is controlled to be 80-90 ℃, and the vacuum degree is controlled to be 720-750 mmHg; adjusting the content of the L-camphor to 87.5-88.5% by adding ice oil; entering a filter press to filter impurities, wherein the operating pressure is less than or equal to 3 bar; putting the mixture into a crystallization warehouse, and crystallizing for 12 to 14 days at the temperature of between 2 ℃ below zero and 8 ℃ below zero; filtering and separating the semi-finished product menthol and ice oil by negative pressure suction; freezing out the ice oil at the temperature of between 10 ℃ below zero and 20 ℃ below zero for 16 to 24 hours, and separating out the wool oil; dehydrating the wool oil to be lower than 0.03%, controlling the temperature to be 80-90 ℃, and controlling the vacuum degree to be 720-750 mmHg; and (3) feeding the dehydrated dementholized oil into a distillation kettle, controlling the temperature to be 100-150 ℃ and the vacuum degree to be 720-750 mmHg, separating dementholized peppermint oil and residues, feeding the dementholized peppermint oil into a filter press to filter impurities, and obtaining the dementholized peppermint oil, wherein the operating pressure is less than or equal to 3 bar.
Step seven: diluting the above Chinese medicinal extracts with water and ethanol to obtain rhinitis drops with different concentrations, and packaging.
The rhinitis drop is prepared from all natural medicines, has no toxic or side effect and dependence, and has the effects of broad-spectrum sterilization, inflammation diminishing, virus resistance, nasal mucosa protection, nasal mucosa nutrition, immunity enhancement, microcirculation improvement and damaged tissue repair promotion through clinical verification; and has the advantages of convenient use, high cure rate and difficult recurrence.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (6)
1. The rhinitis drop for relieving nasal obstruction is characterized by comprising the following raw materials in parts by weight: 35-40 parts of cocklebur fruit oil, 40-45 parts of magnolia flower volatile oil, 15-20 parts of rhizoma paridis extract, 5-10 parts of rhizoma acori graminei extract, 5-8 parts of radix angelicae extract and 0.5-1 part of dementholized peppermint oil.
2. The rhinitis drop for relieving the nasal obstruction of claim 1, wherein the rhinitis drop is prepared from the following raw materials in parts by weight: 38 parts of xanthium sibiricum oil, 42 parts of magnolia flower volatile oil, 18 parts of rhizoma paridis extract, 7 parts of rhizoma acori graminei extract, 6 parts of angelica dahurica extract and 0.8 part of dementholized peppermint oil.
3. A method for preparing rhinitis drops as claimed in claim 1, wherein the method comprises the following steps:
the method comprises the following steps: cleaning fructus Xanthii, drying, parching, removing thorns, pulverizing, grinding into powder, adding into alcohol solvent, ultrasonic treating, filtering, concentrating the filtrate to obtain oily substance, adding the oily substance into vegetable oil, heating under stirring, sterilizing, cooling, and packaging to obtain fructus Xanthii oil.
Step two: drying and pulverizing flos Magnoliae fruit, adding 60% ethanol solution 5 times of flos Magnoliae fruit, extracting with ultrasonic wave, filtering, and concentrating the filtrate until there is no alcohol smell; eluting the obtained concentrated solution with 60% chloroform, collecting eluate, concentrating, and drying to obtain volatile oil.
Step three: extracting dried rhizoma paridis with 55% ethanol under reflux, and mixing extractive solutions.
Step four: adding 10 times of water into rhizoma Acori Graminei, extracting at 95 deg.C for 4 times, filtering, concentrating under reduced pressure, adding ethanol, settling, collecting supernatant, adsorbing with resin and active carbon, eluting with ionized water and ethanol, collecting eluate, and concentrating under reduced pressure.
Step five: crushing the angelica dahurica into coarse powder, adding 75% ethanol, heating and soaking for 3 hours, heating again, starting reflux extraction to obtain an extracting solution, and conveying the extracting solution to a liquid medicine storage tank; adding 75% ethanol into the extraction tank, soaking at normal temperature, heating, refluxing, extracting to obtain extractive solution, transferring the extractive solution to a medicinal liquid storage tank, and mixing the extractive solutions; pumping the extractive solution in the medicinal liquid storage tank into a reduced pressure concentration tank for concentrating and extracting.
4. The method for preparing rhinitis drop according to claim 3, wherein the drying temperature in the first step is 100 ℃ and the drying time is 5-10 min.
5. The method for preparing rhinitis drop according to claim 3, wherein in the fourth step, the amount of activated carbon is 1mL of activated carbon per 1g of rhizoma Acori Graminei.
6. The method for preparing rhinitis drop according to claim 3, wherein in the fifth step, the heating temperature is 75-78 ℃, the steam pressure for concentration and extraction is less than or equal to 0.1MPa, the vacuum degree is 0.06-0.08MPa, and the concentration temperature is 40-80 ℃.
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