CN108066630A - A kind of Chinese and Western medicine compound preparation for treating functional dyspepsia FD and preparation method - Google Patents

A kind of Chinese and Western medicine compound preparation for treating functional dyspepsia FD and preparation method Download PDF

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CN108066630A
CN108066630A CN201610997387.1A CN201610997387A CN108066630A CN 108066630 A CN108066630 A CN 108066630A CN 201610997387 A CN201610997387 A CN 201610997387A CN 108066630 A CN108066630 A CN 108066630A
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western medicine
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王开欣
王金红
臧运香
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The invention discloses a kind of Chinese and Western medicine compound preparation for treating functional dyspepsia FD and preparation methods, belong to pharmaceutical technology field；The raw material of Chinese and Western medicine compound preparation active ingredient of the present invention forms：Itopride, domperidone, Olsalazine, Semen Herpetospermi, Herba Pogostemonis, sorghum, common anneslea bark or leaf, lobus cardiacus hops, carrot, himalayan prinsepia fruit, mushroom, Huang Miangui, scabrous doellingeria root, papaya, turnip, shiningleaf birch bark and wild rice root；Chinese and Western medicine compound preparation of the present invention has the effect of notable to various symptoms caused by treatment functional dyspepsia FD, it is and convenient to take, the course for the treatment of is shorter, quick result, good absorption effect, securely and reliably, cost are relatively low, difficulty in relapse after healing is controlled, also there is righting qi-restoratives, spleen benefiting and stimulating the appetite, promoting qi circulation and removing obstruction in the collateral.

Description

A kind of Chinese and Western medicine compound preparation for treating functional dyspepsia FD and preparation method
Technical field
The present invention relates to pharmaceutical technology field more particularly to a kind of Chinese and Western medicine compound preparations for treating functional dyspepsia FD And preparation method.
Background technology
Functional dyspepsia FD is also known as indigestion, refer to epigastric pain, big belly, early satiety, belch, loss of appetite, The malaise symptoms such as Nausea and vomiting exclude one group of clinical syndrome for causing the organic disease of above-mentioned symptom on inspection.Symptom can Continue or recurrent exerbation, the course of disease are more than one month or add up in past December more than 12 weeks, functional dyspepsia FD It is clinically the most common type Functional Gastrointestinal Disease.
Obstacle occurs for the diastole of holding of stomach bottom after feed, antro-duodenal motor coordination is disorderly and the high factors such as quick of internal organ with Functional dyspepsia FD morbidity is related；Psychology, environment and social factor can influence, aggravate the clinic of patients with functional dyspepsia Performance.The clinical manifestation of functional dyspepsia FD atypism, mainly have epigastric pain, big belly, early satiety, belch, loss of appetite, Nausea and vomiting etc..Can occur individually or with one group of symptom, early satiety has full sense soon after referring to feed, so that dietary intake is bright Aobvious to reduce, big belly is mostly occurred in after the meal or in continuation dining postemphasis.Early saturation big belly is often accompanied by belch；Nausea is vomitted It spits uncommon, is frequently experienced in the patient of gastric emptying obvious postpone, vomiting is mostly when meal gastric content.Many patients while companion There are the mental symptoms such as insomnia, anxiety, depression, headache, absent minded, these symptoms are psychological with " probably cancer " in some patientss It is related.Symptom can also change in the course of disease, and how slow onset is, for years, and continuation or recurrent exerbation, many patients have The risk factors such as diet, spirit.
It is mostly at present using Chinese medicine and western medicine for the treatment of functional dyspepsia FD, western medicine dependence is strong, It is palliative and expensive, and Chinese medicine is responded well to treatment relatively slowly, the course for the treatment of is longer, and some need is long-term use of, therefore, research The drug that a kind of Chinese and Western medicine is combined becomes important topic to treat functional dyspepsia FD.
The content of the invention
The present invention provides a kind of Chinese and Western medicine compound preparation for treating functional dyspepsia FD and preparation methods；In the present invention Compound Western medicine preparation has the effect of notable to various symptoms caused by treatment functional dyspepsia FD, and takes
With conveniently, the course for the treatment of is shorter, and quick result, good absorption effect, securely and reliably, cost are relatively low, controls difficulty in relapse after healing, also has There is the effect of righting qi-restoratives, spleen benefiting and stimulating the appetite, promoting qi circulation and removing obstruction in the collateral.
To achieve the above object, technical scheme is implemented as follows：
The original of the Chinese and Western medicine compound preparation active ingredient is made in a kind of Chinese and Western medicine compound preparation for treating functional dyspepsia FD Material composition and parts by weight are：
0.02~0.06 part of Itopride, 0.01~0.05 part of domperidone, 0.01~0.05 part of Olsalazine, Semen Herpetospermi 48 ~64 parts, 47~63 parts of Herba Pogostemonis, 47~63 parts of sorghum, 46~62 parts of common anneslea bark or leaf, 45~61 parts of lobus cardiacus hops, carrot 45~ 61 parts, 44~60 parts of himalayan prinsepia fruit, 44~60 parts of mushroom, yellow 44~60 parts of the osmanthus in Burma, 43~59 parts of scabrous doellingeria root, papaya 43~ 59 parts, 42~58 parts of turnip, 40~56 parts of 41~57 parts of shiningleaf birch bark and wild rice root.
Be made the Chinese and Western medicine compound preparation active ingredient raw material composition and parts by weight be：
0.03~0.05 part of Itopride, 0.02~0.04 part of domperidone, 0.02~0.04 part of Olsalazine, Semen Herpetospermi 52 ~60 parts, 51~59 parts of Herba Pogostemonis, 51~59 parts of sorghum, 50~58 parts of common anneslea bark or leaf, 49~57 parts of lobus cardiacus hops, carrot 49~ 57 parts, 48~56 parts of himalayan prinsepia fruit, 48~56 parts of mushroom, yellow 48~56 parts of the osmanthus in Burma, 47~55 parts of scabrous doellingeria root, papaya 47~ 55 parts, 46~54 parts of turnip, 44~52 parts of 45~53 parts of shiningleaf birch bark and wild rice root.
Be made the Chinese and Western medicine compound preparation active ingredient raw material composition and parts by weight be：
0.04 part of Itopride, 0.03 part of domperidone, 0.03 part of Olsalazine, 56 parts of Semen Herpetospermi, 55 parts of Herba Pogostemonis, sorghum 55 parts, 54 parts of common anneslea bark or leaf, 53 parts of lobus cardiacus hops, 53 parts of carrot, 52 parts of himalayan prinsepia fruit, 52 parts of mushroom, yellow 52 parts of the osmanthus in Burma, east wind 48 parts of 51 parts of dish root, 51 parts of papaya, 50 parts of turnip, 49 parts of shiningleaf birch bark and wild rice root.
A kind of preparation method for the Chinese and Western medicine compound preparation for treating functional dyspepsia FD, including carrying for following western medicine composition Taking technique step：
（1）Itopride is put into container, adds in the distilled water of 1~2 times of amount, dilution is placed in microwave dryer with 5~8 DEG C temperature low temperature drying, extraction are ground, and obtain 180 targeted fine powders, spare；
（2）Domperidone and Olsalazine are put into medicinal cupping, stirred evenly with mixer, is put into baking oven
70 DEG C of drying postcoolings, extraction are ground, and obtain 200 targeted fine powders, spare；
（3）By above-mentioned steps（1）~（2）The fine powder of acquisition is put into mixing in container, spare.
A kind of preparation method for the Chinese and Western medicine compound preparation for treating functional dyspepsia FD, including carrying for following traditional Chinese medicine ingredients Taking technique step：
（1）Semen Herpetospermi, Herba Pogostemonis and lobus cardiacus hops are put into container, add in the distilled water of 5~8 times of amounts, heating boils 2~ 3 it is small when, extract, filtering obtains filtrate, and heating is concentrated into paste, is put into 70 DEG C of drying postcoolings of baking oven, and extraction is ground, obtained 160 targeted fine powders, it is spare；
（2）Chinese medicine sorghum, common anneslea bark or leaf and scabrous doellingeria root are put into container, processing is crushed, grinds, obtained 180 purposes Fine powder, it is spare；
（3）Carrot, turnip and wild rice root are cleaned, shreds, is put into container, twists juice, impurity is filtered, stays juice spare；
（4）Himalayan prinsepia fruit and yellow remote osmanthus are cleaned, when 60% alcohol solution dippings 1~2 of 3 times of amounts of immersion are small, heating extraction 3 Hour, ethyl alcohol is recycled, filtration obtains filtrate, spare；
（5）Mushroom, papaya and shiningleaf birch bark are put into container, add in the distilled water of 3~6 times of amounts, it is small that heating boils 1~2 When, it extracts, filtering obtains filtrate, spare；
（6）By above-mentioned steps（1）~（5）Fine powder, juice and the filtrate of acquisition are mixed, and after stirring and dissolving is uniform, heating is dense Shorten thick paste into, it is spare.
A kind of preparation method for the Chinese and Western medicine compound preparation for treating functional dyspepsia FD, by the Western medicine fine powder and Chinese medicine Thick paste is mixed, and after stirring and dissolving is uniform, Chinese and Western medicine of the capsule to get the treatment functional dyspepsia FD is made in extraction Compound preparation.
The pharmacological property of Chinese and Western medicine used in the present invention is as follows：
Itopride：It is odorless for white powder, bitter.For various symptoms caused by functional dyspepsia FD.
Domperidone：For treating as caused by gastric emptying, reflux gastritis, chronic gastritis, reflux esophagitis Indigestion symptom.
Olsalazine：Its sodium salt is commonly used, for white group white crystalline powder, fusing point>300℃.It is acute and chronic for treating Ulcerative colitis and regional ileitis, and for the long-term treatment maintaining treatment of paracmasis.
Semen Herpetospermi：Bitter, it is cold in nature.Clearing liver cholagogic, invigorating the spleen help fortune.Main icteric catarrhal jaundice, cholecystitis, digestion is not It is good.
Herba Pogostemonis：Acrid flavour, hardship, it is warm-natured.Expelling wind and clearing away cold, middle benefit gas qi-regulating.Main anemofrigid cold, cough and asthma is out of breath, and abdominal distention disappears Change bad, diarrhea dysentery abdominal pain, the whole body is numb, traumatic injury.
Sorghum：It is sweet in flavor, puckery, it is warm-natured；Returns spleen, stomach, lung channel.Invigorating the spleen to arrest diarrhea, resolving sputum are calmed the nerves.Main splenasthenic diarrhea, cholera, digestion It is bad, productive cough due to phlegm-damp, insomnia and dreamful sleep.
Common anneslea bark or leaf：Puckery, slight bitter, it is cool in nature；Return liver, stomach, large intestine channel.Promoting qi circulation and relieving pain, help digestion antidiarrheal.Main heart and stomach pain, disappears Change bad, rush down dysentery, hepatitis.
Lobus cardiacus hops：Bitter, it is mild-natured.Stomach strengthening and digestion promoting, calm diuresis, treating tuberculosis.Cure mainly anorexia, indigestion, hysteria The diseases such as disease, insomnia, chronic tuberculosis, cystitis.
Carrot：It is sweet in flavor, pungent, it is mild-natured；Returns spleen, liver, lung channel.Invigorating spleen, nourishing liver for improving eyesight, preventing phlegm from forming and stopping coughing are clearing heat and detoxicating. Main spleen eating less, physically weak weak, abdominal pain let out dysentery, blurring of vision, night blindness, cough and asthma, pertussis, abscess of throat, measles, varicella, Furuncle, burn, anal fistula.
Himalayan prinsepia fruit：Bitter, acid, it is cool in nature；Return liver warp.Stomach strengthening and digestion promoting, removing nebula, removing toxic substances.Main accumulation of food in the stomach and intes tine due to indigestion, mesh screen are more Tear, sore ulcer.
Mushroom：It is sweet in flavor, it is mild-natured, it is nontoxic；Return liver, stomach.Righting qi-restoratives, spleen benefiting and stimulating the appetite, wind-dispelling promoting eruption, phlegm-eliminiating and qi-regulating, solution Poison, anticancer.Main healthy tendency is weak, refreshing tired weak, indigestion and loss of appetite, indigestion, anaemia, rickets, hypertension, hyperlipidemia, Chronic Liver Inflammation, night sweat, urinary incontinence, oedema, measles without adequate eruption, nettle rash, malicious mushroom poisoning, tumour.
Yellow Burma osmanthus：Bitter, it is cool in nature；Returns spleen, lung channel.Wind-damp dispelling, throat.Main arthralgia pain due to rheumatism, abscess of throat.
Scabrous doellingeria root：Acrid flavour, it is warm-natured, it is nontoxic.Dispelling wind, promoting the circulation of qi are invigorated blood circulation, analgesic.Control enteritis abdominal pain, arthralgia, bruise Damage.Guangzhou army《Common Chinese herbal medicine handbook》It carries：" wind-dispelling heat, treats snakebite.Control venomous snake bite, red eye, swell pain, abscess of throat, Enteritis abdominal pain.”
Papaya：It is sweet in flavor, it is mild-natured.Help digestion lower breast, eliminating dampness and dredging channels, expelling parasite of detoxifying.Main indigestion, stomach, duodenal ulcer pain Bitterly, milk is rare, arthralgia pain due to rheumatism, extremity numbness, eczema, rotten sore, intestinal parasitical diseases.
Turnip：It is bitter, pungent, sweet, it is warm-natured；The thoughts of returning home, lung, spleen, stomach.Help digestion lower gas, removing toxicity for detumescence.Host dyspepsia, the heart Abdomen crymodynia, cough, furunculosis carbuncle swells.
Shiningleaf birch bark：It is sweet in flavor, pungent, slightly warm in nature.Clearing damp cold dispelling disappears stagnant in, removing toxic substances.Main flu, arthralgia pain due to rheumatism, dyspepsia are satisfied It is swollen, scanty drak urine, acute mastitis, sore, rubella.
Wild rice root：It is sweet in flavor, it is cold in nature.Relieving restlessness is quenched the thirst, clearing heat and detoxicating.Master quenches one's thirst, and vexed, difficult urination, children's measles high fever is not It moves back, jaundice, nosebleed epistaxis, burn and scald.
Compared with prior art, the present invention it has the advantages that：
Chinese and Western medicine compound preparation of the present invention has the effect of notable to various symptoms caused by treatment functional dyspepsia FD, and takes With conveniently, the course for the treatment of is shorter, and quick result, good absorption effect, securely and reliably, cost are relatively low, controls difficulty in relapse after healing, also has and helps The effect of positive qi-restoratives, spleen benefiting and stimulating the appetite, promoting qi circulation and removing obstruction in the collateral.
Specific embodiment
The present invention is further elaborated with reference to specific embodiment.
Embodiment 1
The raw material of Chinese and Western medicine compound preparation active ingredient of the present invention forms and weight is：
Itopride 0.05g, domperidone 0.04g, Olsalazine 0.04g, Semen Herpetospermi 60g, Herba Pogostemonis 59g, sorghum 59g, Common anneslea bark or leaf 58g, lobus cardiacus hops 57g, carrot 57g, himalayan prinsepia fruit 56g, mushroom 56g, Huang Burma osmanthus 56g, scabrous doellingeria root 55g, kind wood Melon 55g, turnip 54g, shiningleaf birch bark 53g and wild rice root 52g.
A kind of preparation method for the Chinese and Western medicine compound preparation for treating functional dyspepsia FD, including carrying for following western medicine composition Taking technique step：
（1）Itopride is put into container, adds in the distilled water of 1~2 times of amount, dilution is placed in microwave dryer with 5~8 DEG C temperature low temperature drying, extraction are ground, and obtain 180 targeted fine powders, spare；
（2）Domperidone and Olsalazine are put into medicinal cupping, stirred evenly with mixer, is put into cold after 70 DEG C of baking oven is dried But, extraction is ground, and obtains 200 targeted fine powders, spare；
（3）By above-mentioned steps（1）~（2）The fine powder of acquisition is put into mixing in container, spare.
A kind of preparation method for the Chinese and Western medicine compound preparation for treating functional dyspepsia FD, including carrying for following traditional Chinese medicine ingredients Taking technique step：
（1）Semen Herpetospermi, Herba Pogostemonis and lobus cardiacus hops are put into container, add in the distilled water of 5~8 times of amounts, heating boils 2~ 3 it is small when, extract, filtering obtains filtrate, and heating is concentrated into paste, is put into 70 DEG C of drying postcoolings of baking oven, and extraction is ground, obtained 160 targeted fine powders, it is spare；
（2）Chinese medicine sorghum, common anneslea bark or leaf and scabrous doellingeria root are put into container, processing is crushed, grinds, obtained 180 purposes Fine powder, it is spare；
（3）Carrot, turnip and wild rice root are cleaned, shreds, is put into container, twists juice, impurity is filtered, stays juice spare；
（4）Himalayan prinsepia fruit and yellow remote osmanthus are cleaned, when 60% alcohol solution dippings 1~2 of 3 times of amounts of immersion are small, heating extraction 3 Hour, ethyl alcohol is recycled, filtration obtains filtrate, spare；
（5）Mushroom, papaya and shiningleaf birch bark are put into container, add in the distilled water of 3~6 times of amounts, it is small that heating boils 1~2 When, it extracts, filtering obtains filtrate, spare；
（6）By above-mentioned steps（1）~（5）Fine powder, juice and the filtrate of acquisition are mixed, and after stirring and dissolving is uniform, heating is dense Shorten thick paste into, it is spare.
A kind of preparation method for the Chinese and Western medicine compound preparation for treating functional dyspepsia FD, by the Western medicine fine powder and Chinese medicine Thick paste is mixed, and after stirring and dissolving is uniform, Chinese and Western medicine of the capsule to get the treatment functional dyspepsia FD is made in extraction Compound preparation.
Usage and dosage：Oral, 2 times a day, each 1 time sooner or later, 1 tablet once（Every 0.5g）, warm water delivery service；6 days are 1 The course for the treatment of, 1~2 course for the treatment of of the lighter, 3~5 courses for the treatment of of severe one can fully recover, and serious patient increases the amount of discretion.
Embodiment 2
The raw material of Chinese and Western medicine compound preparation active ingredient of the present invention forms and weight is：
Itopride 0.04g, domperidone 0.03g, Olsalazine 0.03g, Semen Herpetospermi 56g, Herba Pogostemonis 55g, sorghum 55g, Common anneslea bark or leaf 54g, lobus cardiacus hops 53g, carrot 53g, himalayan prinsepia fruit 52g, mushroom 52g, Huang Burma osmanthus 52g, scabrous doellingeria root 51g, kind wood Melon 51g, turnip 50g, shiningleaf birch bark 49g and wild rice root
48g。
The Chinese and Western medicine compound preparation preparation method processing step and usage and dosage of the present embodiment are same as Example 1.
Embodiment 3
The raw material of Chinese and Western medicine compound preparation active ingredient of the present invention forms and weight is：
Itopride 0.03g, domperidone 0.02g, Olsalazine 0.02g, Semen Herpetospermi 52g, Herba Pogostemonis 51g, sorghum 51g, Common anneslea bark or leaf 50g, lobus cardiacus hops 49g, carrot 49g, himalayan prinsepia fruit 48g, mushroom 48g, Huang Burma osmanthus 48g, scabrous doellingeria root 47g, kind wood Melon 47g, turnip 46g, shiningleaf birch bark 45g and wild rice root 44g.
The Chinese and Western medicine compound preparation preparation method processing step and usage and dosage of the present embodiment are same as Example 1.
Embodiment 4
The raw material of Chinese and Western medicine compound preparation active ingredient of the present invention forms and weight is：
Itopride 0.02g, domperidone 0.01g, Olsalazine 0.01g, Semen Herpetospermi 48g, Herba Pogostemonis 47g, sorghum 47g, Common anneslea bark or leaf 46g, lobus cardiacus hops 45g, carrot 45g, himalayan prinsepia fruit 44g, mushroom 44g, Huang Burma osmanthus 44g, scabrous doellingeria root 43g, kind wood Melon 43g, turnip 42g, shiningleaf birch bark 41g and wild rice root 40g.
The Chinese and Western medicine compound preparation preparation method processing step and usage and dosage of the present embodiment are same as Example 1.
Clinical data：
First, case selection：
As the Chinese and Western medicine compound preparation for the treatment of functional dyspepsia FD, the patients with functional dyspepsia made a definite diagnosis 387 is selected Clinical observation, patient are randomly divided into tri- groups for the treatment of group, control group A and control group B, wherein treatment group 129, male 64, female Property 65,10~73 years old age, average age 41.5 years old, average course of disease 1 year；Control group A 129, wherein male 65, women 64,11~72 years old age, average age 41.5 years old, average course of disease 1 year；Control group B129, wherein male 63, women 66 Example, 10~71 years old age, average age 40.5 years old, average course of disease 1 year.
Treatment group, the course of disease, the degrees of symptoms of tri- groups of cases of control group A and control group B are basically identical, no significance difference It is different, it is comparable.
2nd, medicament selection：
Treatment group uses Chinese and Western medicine compound preparation of the present invention, takes orally, and 2 times a day, each 1 time sooner or later, 1 tablet once（Every 0.5g）, Warm water delivery service；6 days are 1 course for the treatment of, and 1~2 course for the treatment of of the lighter, 3~5 courses for the treatment of of severe one can fully recover, and serious patient abides by doctor It advises and increases the amount.
Control group A takes trimebutine maleate table, and adult is oral, every time 0.1~0.2g (1~2), 3 times a day, root Suitably increase and decrease dosage according to age, symptom or follow the doctor's advice.
Control group B takes Lansoprazole enteric-coated tablet, and daily early morning takes orally 1 time, a 15~30mg or follows the doctor's advice.
3rd, curative effect judges：
It cures：The malaise symptoms such as epigastric pain, big belly, early satiety, belch, loss of appetite, Nausea and vomiting all disappear, and body is extensive Rehabilitation health.It is effective：Above-mentioned symptom is relieved, and body is clearly better.Effectively：Above-mentioned symptom is alleviated, and body is improved. It is invalid：It without alleviation or is aggravated by above-mentioned symptom after treatment.
4th, treatment results：
The above results show that the cure rate and total effective rate for the treatment of group are apparently higher than control group A and control group B.
5th, model case：
1st, Guo, female, 15 years old.Patient abdomen is glutted, and is reluctant to feed, and removes hospital admission, is diagnosed as functional dyspepsia FD, doctor Raw to give Chinese and Western medicine compound preparation treatment of the present invention, after taking 1 course for the treatment of, symptom is clearly better, and continues after taking 2 course for the treatment of, Appetite is recovered, and all symptoms disappear, and recovery from illness, follow-up is without recurrence after 1 year.
2nd, Liang, man, 28 years old.There are the symptoms such as epigastric pain, early satiety, abdominal distension, belch without apparent inducement in patient, and hospital is gone to examine It looks into, is diagnosed as functional dyspepsia FD, used a variety of drug therapies, therapeutic effect is bad, later our hospital's treatment, through taking this Invention Chinese and Western medicine compound preparation is treated, and after taking 1 course for the treatment of, symptom is apparent
Mitigate, continue after taking 2 course for the treatment of, symptom thoroughly disappears, and recovery from illness, follow-up is without recurrence after half a year.
3rd, Luo, female, 35 years old.Patient's gastral cavity abdomen is swollen very, and both sides of the chest are had a pain, and are felt bad, and remove hospital admission, are diagnosed as functionality Indigestion used drug therapy, and therapeutic effect is general, later our hospital's treatment, through taking Chinese and Western medicine compound preparation of the present invention Treatment, after taking 1 course for the treatment of, symptom is substantially reduced, and after taking 3 course for the treatment of, symptom all disappears, and recovery from illness, follow-up is without multiple after 1 year Hair.
4th, Ma, man, 40 years old.Patient's stomach is ached, and turgor deficiency of food indigestion symptom often occurs, removes examination in hospital, makes a definite diagnosis For functional dyspepsia FD, used a variety of drug therapies, therapeutic effect is very poor, after take Chinese and Western medicine compound preparation of the present invention and control It treats, after taking 1 course for the treatment of, symptom is improved, and after taking 2 course for the treatment of, symptom is clearly better, and is continued after taking 2 course for the treatment of, disease Shape all disappears, physical recovery health, recovery from illness, and follow-up is not recurred so far.
5th, Tang, female, 54 years old.Patient's upper abdomen pain, gasteremphraxis, loss of appetite remove hospital admission, are diagnosed as functionality and disappear Change bad, doctor gives Chinese and Western medicine compound preparation of the present invention treatment, and after taking 1 course for the treatment of, symptom is alleviated, and takes 2 treatments Cheng Hou, symptom are relieved, and are continued after taking 1 course for the treatment of, and mental status is good, and symptom disappears, and recovery from illness, follow-up is without multiple after 1 year Hair.
6th, Zheng, man, 69 years old.Patient's epigastric pain, nausea are had a sleepless night, and loss of appetite, feed is less, removes examination in hospital, makes a definite diagnosis For functional dyspepsia FD, doctor gives Chinese and Western medicine compound preparation treatment of the present invention, and after taking 1 course for the treatment of, symptom is mitigated, After taking 2 course for the treatment of, symptom is substantially reduced, continues after taking 1 course for the treatment of, and symptom all disappears, recovery from illness, and follow-up is not multiple so far Hair.
Finally it should be noted that：The above described is only a preferred embodiment of the present invention, it is not that it is made to the present invention The limitation of its form, every without departing from technical solution of the present invention content, that is done in application range according to the invention any repaiies Change, equivalent substitution and improvement etc., still fall within the protection domain of technical solution of the present invention.

Claims (6)

1. a kind of Chinese and Western medicine compound preparation for treating functional dyspepsia FD, it is characterised in that：The Chinese and Western medicine compound system is made The raw material of agent active ingredient forms and parts by weight are：
0.02~0.06 part of Itopride, 0.01~0.05 part of domperidone, 0.01~0.05 part of Olsalazine, Semen Herpetospermi 48 ~64 parts, 47~63 parts of Herba Pogostemonis, 47~63 parts of sorghum, 46~62 parts of common anneslea bark or leaf, 45~61 parts of lobus cardiacus hops, carrot 45~ 61 parts, 44~60 parts of himalayan prinsepia fruit, 44~60 parts of mushroom, yellow 44~60 parts of the osmanthus in Burma, 43~59 parts of scabrous doellingeria root, papaya 43~ 59 parts, 42~58 parts of turnip, 40~56 parts of 41~57 parts of shiningleaf birch bark and wild rice root.
2. a kind of Chinese and Western medicine compound preparation for treating functional dyspepsia FD according to claim 1, it is characterised in that：System Raw material composition and parts by weight into the Chinese and Western medicine compound preparation active ingredient are：
0.03~0.05 part of Itopride, 0.02~0.04 part of domperidone, 0.02~0.04 part of Olsalazine, Semen Herpetospermi 52 ~60 parts, 51~59 parts of Herba Pogostemonis, 51~59 parts of sorghum, 50~58 parts of common anneslea bark or leaf, 49~57 parts of lobus cardiacus hops, carrot 49~ 57 parts, 48~56 parts of himalayan prinsepia fruit, 48~56 parts of mushroom, yellow 48~56 parts of the osmanthus in Burma, 47~55 parts of scabrous doellingeria root, papaya 47~ 55 parts, 46~54 parts of turnip, 44~52 parts of 45~53 parts of shiningleaf birch bark and wild rice root.
3. a kind of Chinese and Western medicine compound preparation for treating functional dyspepsia FD according to claim 1, it is characterised in that：System Raw material composition and parts by weight into the Chinese and Western medicine compound preparation active ingredient are：
0.04 part of Itopride, 0.03 part of domperidone, 0.03 part of Olsalazine, 56 parts of Semen Herpetospermi, 55 parts of Herba Pogostemonis, sorghum 55 parts, 54 parts of common anneslea bark or leaf, 53 parts of lobus cardiacus hops, 53 parts of carrot, 52 parts of himalayan prinsepia fruit, 52 parts of mushroom, yellow 52 parts of the osmanthus in Burma, east wind 48 parts of 51 parts of dish root, 51 parts of papaya, 50 parts of turnip, 49 parts of shiningleaf birch bark and wild rice root.
4. a kind of preparation side for the Chinese and Western medicine compound preparation that functional dyspepsia FD is treated as described in any one of claims 1 to 3 Method, it is characterised in that：Extraction process step including following western medicine composition：
（1）Itopride is put into container, adds in the distilled water of 1~2 times of amount, dilution is placed in microwave dryer with 5~8 DEG C temperature low temperature drying, extraction are ground, and obtain 180 targeted fine powders, spare；
（2）Domperidone and Olsalazine are put into medicinal cupping, stirred evenly with mixer, is put into cold after 70 DEG C of baking oven is dried But, extraction is ground, and obtains 200 targeted fine powders, spare；
（3）By above-mentioned steps（1）~（2）The fine powder of acquisition is put into mixing in container, spare.
5. a kind of preparation side for the Chinese and Western medicine compound preparation that functional dyspepsia FD is treated as described in any one of Claims 1 to 4 Method, it is characterised in that：Extraction process step including following traditional Chinese medicine ingredients：
（1）Semen Herpetospermi, Herba Pogostemonis and lobus cardiacus hops are put into container, add in the distilled water of 5~8 times of amounts, heating boils 2~ 3 it is small when, extract, filtering obtains filtrate, and heating is concentrated into paste, is put into 70 DEG C of drying postcoolings of baking oven, and extraction is ground, obtained 160 targeted fine powders, it is spare；
（2）Chinese medicine sorghum, common anneslea bark or leaf and scabrous doellingeria root are put into container, processing is crushed, grinds, obtained 180 purposes Fine powder, it is spare；
（3）Carrot, turnip and wild rice root are cleaned, shreds, is put into container, twists juice, impurity is filtered, stays juice spare；
（4）Himalayan prinsepia fruit and yellow remote osmanthus are cleaned, when 60% alcohol solution dippings 1~2 of 3 times of amounts of immersion are small, heating extraction 3 Hour, ethyl alcohol is recycled, filtration obtains filtrate, spare；
（5）Mushroom, papaya and shiningleaf birch bark are put into container, add in the distilled water of 3~6 times of amounts, it is small that heating boils 1~2 When, it extracts, filtering obtains filtrate, spare；
（6）By above-mentioned steps（1）~（5）Fine powder, juice and the filtrate of acquisition are mixed, and after stirring and dissolving is uniform, heating is dense Shorten thick paste into, it is spare.
6. the preparation side of the Chinese and Western medicine compound preparation of functional dyspepsia FD is treated according to claim 4 or claim 5 Method, it is characterised in that：The Western medicine fine powder and traditional Chinese medicine thick paste are mixed, after stirring and dissolving is uniform, capsule is made in extraction, i.e., Obtain the Chinese and Western medicine compound preparation of the treatment functional dyspepsia FD.
CN201610997387.1A 2016-11-14 2016-11-14 A kind of Chinese and Western medicine compound preparation for treating functional dyspepsia FD and preparation method Withdrawn CN108066630A (en)

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