CN108042686A - A kind of compound bruises and sprains plaster and preparation method thereof - Google Patents
A kind of compound bruises and sprains plaster and preparation method thereof Download PDFInfo
- Publication number
- CN108042686A CN108042686A CN201711190059.1A CN201711190059A CN108042686A CN 108042686 A CN108042686 A CN 108042686A CN 201711190059 A CN201711190059 A CN 201711190059A CN 108042686 A CN108042686 A CN 108042686A
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- parts
- cream powder
- powder
- rhizome
- plaster
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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Abstract
The present invention relates to a kind of compound bruises and sprains plaster and preparation method thereof, belong to traditional Chinese medicine plaster technical field, which is made by the component of following mass parts：100~120 parts of 20~30 parts of scythian lamb rhizome cream powder, 20~30 parts of anisetree bark cream powder, 20~30 parts of rhizome of davallia cream powder, 15~20 parts of teasel root cream powder, 15~20 parts of Radix Notoginseng cream powder, 15~20 parts of Paris polyphylla cream powder, 10~15 parts of oldenlandia diffusa cream powder, 10~15 parts of the root bark of white mulberry, 10~15 parts of safflower and vegetable oil；The present invention by by extracts such as scythian lamb rhizome, anisetree bark, the rhizome of davallia, teasel root, Radix Notoginseng, Paris polyphylla, oldenlandia diffusa, the root bark of white mulberry, safflowers according to theory of traditional Chinese medical science, scientific compatibility, function of human body is adjusted on the whole, so as to reach hemostasis callus, promoting blood circulation to remove blood stasis, anti-inflammatory go to swell, strengthening the muscles and bones and other effects, the plaster of the present invention is in affected part, sustainable effect injury enhances drug effect.
Description
Technical field
The present invention relates to a kind of compound bruises and sprains plaster and preparation method thereof, belong to traditional Chinese medicine plaster technical field.
Background technology
Traumatic injury refer mainly to because fall flutter, impact etc. caused by soft tissue injury, wound swelling pain, skin and flesh breakage go out
Blood, also including tumble injury incised wound etc..Main pharmacological stops up stagnant, blood for hemostasis and holds one's breath resistance, therefore using pain, swelling mainly to show.It controls
Treat suitable filling liver kidney, strengthening the bones and muscles, promoting blood circulation and removing obstruction in channels, relaxing muscles and tendons promoting the circulation of qi.There are many medicinal liquor or medicine for the treatment of traumatic injury in the prior art
Water, ZHONGHUA DIEDA WAN, blood-activating and pain-stopping capsules, Typhonium flagelliforme (Lodd.) Blume powder, Yunnan Baiyao bonesetting liquid, BOGU SHUI, SHANGKE DIEDA PIAN, dragon's blood arogel
Capsule, stretch muscle capsule, powdered medicine for coaptation is controlled with pseudo-ginseng blood-circulation-invigovating cream etc., curative effect is slow.
Scythian lamb rhizome is the rhizome of Dicksoniaceae plant Cibotium barometz.Scythian lamb rhizome rhizome starch-containing 30% or so.Chain fern
Rhizome starch-containing up to 48.5%, and class containing tannin.Rhizome is starch-containing and aspidinol；The pubescence of rhizome contains tannin and pigment.Gold
Golden yellow fine hair, is good hemostatic on hair rhizoma cibotii plant.At wounds streamed blood, fine hair is stained with, is bled at once with regard to that can stop.
Root-like stock also has filling liver kidney, diuresis and other effects.Rhizoma cibotii category strong muscles and bones medicine has the disease that muscles and bones is not good for pair for the treatment of and health care
Recast is used.Cure mainly stiff lumbar vertebra pain, it is impossible to pitching, the diseases such as sufficient knee weakness and lumbago due to wind-wetness evil.There is temperature compensation to take the photograph effect admittedly, treatment frequent micturition,
The enuresis makes essence, with inferior.
Anisetree bark is also Cortex Illicii, Cortex schizophragmatis integrifolii radicis, Chinese hydrangeavine root-bark, belongs to Magnoliaceae.Its ingredient 0.30%-0.71% containing volatile oil,
Inside have：α-and nopinene, lauro lene, 1, 8-Cineole, linalool, safrole, camphor, Bronyl acetate, laurene etc. 28 into.
Rheumatic arthritis can be treated；Lumbar muscle strain；Centipde-bite,《Xinhua's book on Chinese herbal medicine outline》, bark：Acrid flavour, it is puckery, warm-natured, it is slightly poisonous.Have
Dispeling wind and dehumidification, the function of promoting qi circulation and relieving pain.
The rhizome of davallia, alias：Precipice ginger, rock connect ginger, delevay drynaria, meat it is broken mend, stone is broken mends, flying apsaras mouse, Niu Feilong, sudden wind, flies
Moth grass.Polypodiales, Davalliaceae pteridophyte.Its medicinal efficacy is：1. The strong bone of kidney tonifying：It can promote absorption of the bone to calcium, improve
Blood calcium and serum phosphorus levels, are conducive to bone calcification and bone salts is formed；2. anti-medicine poison：Originally water decoction is built up one's health by taking tonic to kanamycins and streptomysin
Caused toxicity has apparent detoxicating functions, can mitigate toxic action of the kanamycins to cochlea, to the ototoxicity of drug
There is certain prevention effect, protect kidney, damage of the kanamycins to kidney can be reduced；3. reducing blood lipid, antithrombotic：The rhizome of davallia is more
Sugar lime, steroidal lactone and flavanone glycosides play the role of reducing serum cholesterol.Especially it is more prominent with the effect of polysaccharide hydrochlorate
Go out；4. cardiac effect：Rhizome of davallia flavanone glycosides has cardiac effect, can increase rabbit myocardial contractive power, the rhythm of the heart is regular, is direct
Act on cardiac muscle, and Non nervous system；5. protecting liver and detoxication：The rhizome of davallia can activate liver drug enzyme, mitigate or release drug to liver
Damage, there is protecting liver and detoxication.6. kidney tonifying is invigorated blood circulation, hemostasis：Control kidney deficiency chronic diarrhea and pain in the back, arthralgia pain due to rheumatism, dentalgia, tinnitus falls
Flash frustrate, bone fracture, appendicitis, alopecia areata, corn.
Teasel root, original name " Resurrection pill " also known as shaven head.Its slightly warm in nature, it is bitter, pungent；Return liver and kidney channel.There are filling liver kidney, strengthening tendons
Bone, continuous injured stop the effect of uterine bleeding, available for treatment kidney deficiency and liver, soreness and weakness of waist and knees, arthralgia pain due to rheumatism, injury of tendon and muscle fracture, uterine bleeding, tire
The illnesss such as leakage, injury from falling down.
Radix Notoginseng, alias pseudo-ginseng powder are invaluable.It is warm-natured, sweet and slightly bitter taste.Rich in notoginsenoside, notoginseng polysaccharide, dencichine, Huang
Ketone active ingredient has hemostasis, promoting blood circulation and removing blood stasis, detumescence ding-tong, strengthening by means of tonics, antifatigue, resist oxygen lack, anti-aging, reducing blood lipid, drop
Blood pressure improves the effects that body's immunity.
Paris polyphylla is liliaceous plant Yunnan Rhizoma Paridis or the dry rhizome of paris polyphylla.Its bitter, cold nature；It is slightly poisonous.
There is clearing heat and detoxicating a, swelling and pain relieving, the effect of cool liver is calmed the frightened, be usually used in furunculosis carbuncle swells, abscess of throat, snakebite and bugbite, the pain of injury caused by falling and tumbling,
Convulsion.
Oldenlandia diffusa, alias：HERBA HEDYOTIS DIFFUSAE, tang Huang, snake needle grass, Radix Picriae felterrae, two leaf humulus, white flower cross are careless, sharp knife is careless,
A, waterplantain ottelia herb, snake Lei grass, crane tongue grass, hang down loosely draft to be annual.It is its patent medicine bitter, light, it is cold in nature.Primary efficacy is clear
Thermal detoxification, medicinal powder for relieving pain knot, promoting urination and removing dampness.Outstanding kind treatment various types inflammation.In clinical practice, if finding, oldenlandia diffusa is matched somebody with somebody
5 is proper, can treat a variety of diseases.
The root bark of white mulberry, Morus machaka or arbor, high 3--15m.Bark canescence.Pharmacology is made：1. sedation and analgesia acts on,
The extract of the fat-soluble solvent such as petroleum ether, ether, the ethyl acetate of the root bark of white mulberry gives mouse intravenous, can reduce the spontaneous work of mouse
It is dynamic, and have anticonvulsant effect；2. anti-inflammatory effect, root bark of white mulberry water extract gathers to Oral Administration in Rats or injection Carrageenan and Portugal
Swollen feet caused by sugar has inhibitory action；3. antibacterial action, root bark of white mulberry decoction has staphylococcus aureus stronger inhibition
Effect；Also there is slight inhibitory action to typhoid bacillus and shigella flexneri.
Safflower, alias：Red blue flower, thorn safflower, composite family, safflower platymiscium, dry tubular flower is orange red, and floral tube is narrow thin,
Apex 5 is split, and sliver is narrow linear, and flower pesticide yellow is unified into pipe, is higher by outside sliver, and there is column cap exposing in center.Tool is special fragrant
Gas, mildly bitter flavor.With flower piece is long, color is scarlet, the soft person of matter is preferred.With invigorate blood circulation, stasis eliminatings analgesic.Controlling through closing, abdominal mass are difficult
Production, stillborn foetus, disease that postpartum lochia can't go, hemostasis are had a pain, carbuncle swells, injury from falling down.
The content of the invention
Existing drug ingredient is complicated for the above-mentioned prior art, the slow problem of curative effect, and the present invention provides a kind of compound bruise
Sprain plaster and preparation method thereof, the present invention is by by scythian lamb rhizome, anisetree bark, the rhizome of davallia, teasel root, Radix Notoginseng, Paris polyphylla, long-noded pit viper
For the extracts such as tongue grass, the root bark of white mulberry, safflower according to theory of traditional Chinese medical science, scientific compatibility adjusts function of human body on the whole, so as to reach only
Blood callus, promoting blood circulation to remove blood stasis, anti-inflammatory go to swell, strengthening the muscles and bones and other effects, while ultrasonic wave auxiliary reflux of the present invention extracts
I.e. active ingredient in Chinese medicine, micro constitutent and heat-sensitive ingredients will not be destroyed can improve extracting efficiency to technology well again
And this ultrasonic wave auxiliary reflux extraction equipment is at low cost, easy to operate, applied widely.
A kind of compound bruises and sprains plaster, is made by the component of following mass parts：20~30 parts of scythian lamb rhizome cream powder, maple
20~30 parts of skin cream powder, 20~30 parts of rhizome of davallia cream powder, 15~20 parts of teasel root cream powder, 15~20 parts of Radix Notoginseng cream powder, Paris polyphylla cream powder
15~20 parts, 10~15 parts of oldenlandia diffusa cream powder, 10~15 parts of the root bark of white mulberry, 10~15 parts of safflower and vegetable oil 100~120
Part.
A kind of preparation method of compound bruises and sprains plaster, is as follows：
(1) powder processed：Respectively by scythian lamb rhizome, anisetree bark, the rhizome of davallia, teasel root, Radix Notoginseng, Paris polyphylla, oldenlandia diffusa, Sang Bai
Skin, safflower crush and 60 mesh that sieve, and then -60 powder material of each component is carried out respectively for 70~80wt% edible ethanols with concentration
The reflux extraction of ultrasonic wave assisted decompression, the wherein mass volume ratio of each component powder and edible ethanol are 1:10~15g/mL, leaching
The time is carried as 1~2h, 55~60 DEG C of extraction temperature after extraction, with filtered through gauze, takes filtrate, filter residue is extracted again, is filtered,
Merge 2 filtrates and mixing, by mixed liquor again by centrifugal treating, centrifuged supernatant is concentrated, that is, is prepared into the cream of each component
Powder；
(2) batch mixing：20~30 parts of scythian lamb rhizome cream powder, 20~30 parts of anisetree bark cream powder, the bone that step (1) is prepared
It is broken to paste up 20~30 parts of powder, 15~20 parts of teasel root cream powder, 15~20 parts of Radix Notoginseng cream powder, 15~20 parts of Paris polyphylla cream powder, oldenlandia
Careless 10~15 parts of cream powder, 10~15 parts of root bark of white mulberry cream powder, 10~15 parts of safflower cream powder are mixed to obtain mixture；
(3) refine：It is mixture mixing that 100~120 parts of vegetable oil is obtained with step (2) by mass parts and is heated to
It 50~60 DEG C, is stirred continuously in heating process, forms ointment；
(4) plaster is made：The ointment that step (3) obtains is coated in brown paper or medicated plaster cloth, plaster is made.
The compound bruises and sprains plaster, external application use.
The beneficial effects of the invention are as follows：
(1) present invention is by by scythian lamb rhizome, anisetree bark, the rhizome of davallia, teasel root, Radix Notoginseng, Paris polyphylla, oldenlandia diffusa, Sang Bai
The extracts such as skin, safflower adjust function of human body on the whole according to theory of traditional Chinese medical science, scientific compatibility, so as to reach hemostasis callus, work
Blood dissipates the stasis of blood, anti-inflammatory goes to swell, strengthening the muscles and bones and other effects.
(2) ultrasonic wave auxiliary reflux microwave leaching technology of the present invention will not destroy active ingredient in Chinese medicine, micro-
Amount ingredient and heat-sensitive ingredients can improve extracting efficiency well again and this ultrasonic wave auxiliary reflux extraction equipment into
This is low, easy to operate, applied widely.
(3) plaster of the invention enhances drug effect in affected part, sustainable effect injury.
Description of the drawings
Fig. 1 is the process flow chart of the present invention.
Specific embodiment
The present invention is described in further detail below by drawings and examples, but protection scope of the present invention is not limited to
In the content.
Embodiment 1
The compound bruises and sprains specific medicinal liquor formula, is made by following components：Scythian lamb rhizome cream powder 20g, anisetree bark cream powder
20g, rhizome of davallia cream powder 20g, teasel root cream powder 15g, Radix Notoginseng cream powder 15g, Paris polyphylla cream powder 15g, oldenlandia diffusa cream powder 10g, Sang Bai
Skin 10g, safflower 10g and vegetable oil 100g.
As shown in Figure 1, for the preparation method of the compound bruises and sprains plaster, it is as follows：
(1) powder processed：Respectively by scythian lamb rhizome, anisetree bark, the rhizome of davallia, teasel root, Radix Notoginseng, Paris polyphylla, oldenlandia grass meal, Sang Bai
Skin, safflower crush and 60 mesh that sieve, then with concentration is that 70wt% edible ethanols carry out ultrasonic wave assisted decompression to each component powder
Reflux extraction, the wherein mass volume ratio of the powder of each component and edible ethanol are 1:10g/mL, ultrasonic power 2000W,
Extraction time is 1h, and extraction temperature is 55 DEG C, using 6 layers of filtered through gauze after extraction, takes filtrate, filter residue is extracted again, is filtered,
Merge 2 filtrates and mixing, by mixed liquor again by centrifugal treating, centrifuged supernatant vacuum-concentrcted is prepared into each
The cream powder (no alcohol) of component；
(2) batch mixing：Scythian lamb rhizome cream powder 20g, anisetree bark cream powder 20g, the rhizome of davallia cream powder that step (1) is prepared
20g, teasel root cream powder 15g, Radix Notoginseng cream powder 15g, Paris polyphylla cream powder 15g, oldenlandia diffusa cream powder 10g, root bark of white mulberry cream powder 10g, safflower
Cream powder 10g is mixed to obtain mixture；
(3) refine：Mixture mixing that the vegetable oil of 100g and step (2) are obtained simultaneously is heated to 50 DEG C, heating process
In be stirred continuously, formed ointment；
(4) plaster is made：It is taken ointment that step (3) obtains with bamboo clappers and is coated in brown paper or medicated plaster cloth and plaster is made.
The compound bruises and sprains plaster, external application use, and effect is preferable.
Embodiment 2
The compound bruises and sprains specific medicinal liquor formula, is made by following components：Scythian lamb rhizome cream powder 30g, anisetree bark cream powder
30g, rhizome of davallia cream powder 30g, teasel root cream powder 20g, Radix Notoginseng cream powder 20g, Paris polyphylla cream powder 20g, oldenlandia diffusa cream powder 15g, Sang Bai
Skin 15g, safflower 15g and vegetable oil 120g.
As shown in Figure 1, for the preparation method of the compound bruises and sprains plaster, it is as follows：
(1) powder processed：Respectively by scythian lamb rhizome, anisetree bark, the rhizome of davallia, teasel root, Radix Notoginseng, Paris polyphylla, oldenlandia grass meal, Sang Bai
Skin, safflower crush and 60 mesh that sieve, then with concentration is that 80wt% edible ethanols carry out ultrasonic wave assisted decompression to each component powder
Reflux extraction, the wherein mass volume ratio of the powder of each component and edible ethanol are 1:15g/mL, ultrasonic power 2000W,
Extraction time is 2h, and extraction temperature is 60 DEG C, using 6 layers of filtered through gauze after extraction, takes filtrate, filter residue is extracted again, is filtered,
Merge 2 filtrates and mixing, by mixed liquor again by centrifugal treating, centrifuged supernatant vacuum-concentrcted is prepared into each
The cream powder (no alcohol) of component；
(2) batch mixing：Scythian lamb rhizome cream powder 30g, anisetree bark cream powder 30g, the rhizome of davallia cream powder that step (1) is prepared
30g, teasel root cream powder 20g, Radix Notoginseng cream powder 20g, Paris polyphylla cream powder 20g, oldenlandia diffusa cream powder 15g, root bark of white mulberry 15g, safflower 15g are mixed
Obtain mixture；
(3) refine：Mixture mixing that the vegetable oil of 120g and step (2) are obtained simultaneously is heated to 60 DEG C, heating process
In be stirred continuously, formed ointment；
(4) plaster is made：It is taken ointment that step (3) obtains with bamboo clappers and is coated in brown paper or medicated plaster cloth and plaster is made.
Embodiment 3
The compound bruises and sprains specific medicinal liquor formula, is made by following components：Scythian lamb rhizome cream powder 25g, anisetree bark cream powder
25g, rhizome of davallia cream powder 25g, teasel root cream powder 17g, Radix Notoginseng cream powder 17g, Paris polyphylla cream powder 17g, oldenlandia diffusa cream powder 13g, Sang Bai
Skin cream powder 13g, safflower cream powder 13g and vegetable oil 110g.
As shown in Figure 1, for the preparation method of the compound bruises and sprains plaster, it is as follows：
(1) powder processed：Powder processed：Respectively by scythian lamb rhizome, anisetree bark, the rhizome of davallia, teasel root, Radix Notoginseng, Paris polyphylla, oldenlandia diffusa
Powder, the root bark of white mulberry, safflower crush and 60 mesh that sieve, then with concentration to be that 75wt% edible ethanols carry out ultrasonic wave to each component powder auxiliary
Reduced-pressure backflow is helped to extract, the wherein powder of each component and the mass volume ratio of edible ethanol is 1:12g/mL, ultrasonic power
For 2000W, extraction time 1.5h, extraction temperature is 58 DEG C, using 6 layers of filtered through gauze after extraction, takes filtrate, by filter residue again
Extraction, filtering, merge 2 filtrates and mixing, by mixed liquor again by centrifugal treating, by centrifuged supernatant vacuum-concentrcted,
It is prepared into the cream powder (no alcohol) of each component；
(2) batch mixing：Scythian lamb rhizome cream powder 25g, anisetree bark cream powder 25g, the rhizome of davallia cream powder that step (1) is prepared
25g, teasel root cream powder 17g, Radix Notoginseng cream powder 17g, Paris polyphylla cream powder 17g, oldenlandia diffusa cream powder 13g, root bark of white mulberry cream powder 13g, safflower
Cream powder 13g is mixed to obtain mixture；
(3) refine：Mixture mixing that the vegetable oil of 110g and step (2) are obtained simultaneously is heated to 55 DEG C, heating process
In be stirred continuously, formed ointment；
(4) plaster is made：It is taken ointment that step (3) obtains with bamboo clappers and is coated in brown paper or medicated plaster cloth and plaster is made.
Claims (2)
1. a kind of compound bruises and sprains plaster, which is characterized in that be made by the component of following mass parts：Scythian lamb rhizome cream powder 20~
30 parts, 20~30 parts of anisetree bark cream powder, 20~30 parts of rhizome of davallia cream powder, 15~20 parts of teasel root cream powder, 15~20 parts of Radix Notoginseng cream powder,
15~20 parts of Paris polyphylla cream powder, 10~15 parts of oldenlandia diffusa cream powder, 10~15 parts of the root bark of white mulberry, 10~15 parts of safflower and vegetable oil
100~120 parts.
2. the preparation method of compound bruises and sprains plaster described in claim 1, it is characterised in that be as follows：
(1) powder processed：Respectively by scythian lamb rhizome, anisetree bark, the rhizome of davallia, teasel root, Radix Notoginseng, Paris polyphylla, oldenlandia diffusa, the root bark of white mulberry, red
Pollen is broken and 60 mesh that sieve, and then carries out ultrasound to -60 powder material of each component respectively with concentration for 70~80wt% edible ethanols
The reflux extraction of ripple assisted decompression, the wherein mass volume ratio of each component powder and edible ethanol are 1:10~15g/mL, during extraction
Between for 1~2h, 55~60 DEG C of extraction temperature after extraction, with filtered through gauze, takes filtrate, filter residue is extracted again, is filtered, and merges 2
Secondary filtrate and mixing, by mixed liquor again by centrifugal treating, centrifuged supernatant is concentrated, that is, is prepared into the cream powder of each component；
(2) batch mixing：20~30 parts of scythian lamb rhizome cream powder, 20~30 parts of anisetree bark cream powder, the rhizome of davallia that step (1) is prepared
20~30 parts of cream powder, 15~20 parts of teasel root cream powder, 15~20 parts of Radix Notoginseng cream powder, 15~20 parts of Paris polyphylla cream powder, oldenlandia diffusa cream
10~15 parts of powder, 10~15 parts of root bark of white mulberry cream powder, 10~15 parts of safflower cream powder are mixed to obtain mixture；
(3) refine：Mixture mixing that vegetable oil and step (2) that mass parts are 100~120 parts are obtained and it is heated to 50~
It 60 DEG C, is stirred continuously in heating process, forms ointment；
(4) plaster is made：The ointment that step (3) obtains is coated in brown paper or medicated plaster cloth, plaster is made.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101744960A (en) * | 2008-12-08 | 2010-06-23 | 徐泽三 | Sangusis draconis notoginseng bone-setting ointment and preparation method thereof |
| CN102949500A (en) * | 2011-08-22 | 2013-03-06 | 天津尖峰弗兰德医药科技发展有限公司 | Externally-applied traditional Chinese medicinal preparation used for foot sprains, and its preparation method |
-
2017
- 2017-11-24 CN CN201711190059.1A patent/CN108042686A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101744960A (en) * | 2008-12-08 | 2010-06-23 | 徐泽三 | Sangusis draconis notoginseng bone-setting ointment and preparation method thereof |
| CN102949500A (en) * | 2011-08-22 | 2013-03-06 | 天津尖峰弗兰德医药科技发展有限公司 | Externally-applied traditional Chinese medicinal preparation used for foot sprains, and its preparation method |
Non-Patent Citations (1)
| Title |
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| 莫小林等: "药材粉碎度、浸泡时间对十一方药酒人参皂苷Rg_1含量和总固体量的影响", 《中国实验方剂学杂志》 * |
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Application publication date: 20180518 |