CN108033990A - 地塞米松中间体的制备方法 - Google Patents

地塞米松中间体的制备方法 Download PDF

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Publication number
CN108033990A
CN108033990A CN201711483575.3A CN201711483575A CN108033990A CN 108033990 A CN108033990 A CN 108033990A CN 201711483575 A CN201711483575 A CN 201711483575A CN 108033990 A CN108033990 A CN 108033990A
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CN
China
Prior art keywords
dexamethasone
preparation
compound
reaction
cyanogenation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711483575.3A
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English (en)
Chinese (zh)
Inventor
杨坤
于传云
周健柳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GUANGXI WANDE PHARMACEUTICAL CO Ltd
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GUANGXI WANDE PHARMACEUTICAL CO Ltd
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Application filed by GUANGXI WANDE PHARMACEUTICAL CO Ltd filed Critical GUANGXI WANDE PHARMACEUTICAL CO Ltd
Priority to CN201711483575.3A priority Critical patent/CN108033990A/zh
Publication of CN108033990A publication Critical patent/CN108033990A/zh
Priority to PCT/CN2019/076373 priority patent/WO2019129309A1/fr
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201711483575.3A 2017-12-29 2017-12-29 地塞米松中间体的制备方法 Pending CN108033990A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201711483575.3A CN108033990A (zh) 2017-12-29 2017-12-29 地塞米松中间体的制备方法
PCT/CN2019/076373 WO2019129309A1 (fr) 2017-12-29 2019-02-27 Procédé de préparation d'un intermédiaire de dexaméthasone

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711483575.3A CN108033990A (zh) 2017-12-29 2017-12-29 地塞米松中间体的制备方法

Publications (1)

Publication Number Publication Date
CN108033990A true CN108033990A (zh) 2018-05-15

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ID=62099058

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CN201711483575.3A Pending CN108033990A (zh) 2017-12-29 2017-12-29 地塞米松中间体的制备方法

Country Status (2)

Country Link
CN (1) CN108033990A (fr)
WO (1) WO2019129309A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109734762A (zh) * 2018-12-05 2019-05-10 郑良彬 一锅法合成16-β甲基甾体化合物的方法
WO2019129309A1 (fr) * 2017-12-29 2019-07-04 广西万德药业有限公司 Procédé de préparation d'un intermédiaire de dexaméthasone

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103910775A (zh) * 2014-03-31 2014-07-09 仙居县圃瑞药业有限公司 17α-羟基黄体酮的合成方法
CN105017377A (zh) * 2015-07-06 2015-11-04 湖南新合新生物医药有限公司 肾上腺皮质激素药物中间体的制备方法
CN103641878B (zh) * 2013-11-22 2016-01-06 湖南新合新生物医药有限公司 倍他米松中间体或其类似物的制备方法
CN105399791B (zh) * 2015-10-27 2017-03-29 江苏远大仙乐药业有限公司 一种倍他米松中间体的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY105302A (en) * 1989-11-27 1994-09-30 Schering Corp Process for dehydrating corticosteroid intermediates.
CN108033990A (zh) * 2017-12-29 2018-05-15 广西万德药业有限公司 地塞米松中间体的制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103641878B (zh) * 2013-11-22 2016-01-06 湖南新合新生物医药有限公司 倍他米松中间体或其类似物的制备方法
CN103910775A (zh) * 2014-03-31 2014-07-09 仙居县圃瑞药业有限公司 17α-羟基黄体酮的合成方法
CN105017377A (zh) * 2015-07-06 2015-11-04 湖南新合新生物医药有限公司 肾上腺皮质激素药物中间体的制备方法
CN105399791B (zh) * 2015-10-27 2017-03-29 江苏远大仙乐药业有限公司 一种倍他米松中间体的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NICHOLAS I. CARRUTHERS ET AL.: "Synthesis of Corticoids from 9ot-Hydroxyandrost-4-ene-3,17-dione", 《JOURNAL OF ORGANIC CHEMISTRY》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019129309A1 (fr) * 2017-12-29 2019-07-04 广西万德药业有限公司 Procédé de préparation d'un intermédiaire de dexaméthasone
CN109734762A (zh) * 2018-12-05 2019-05-10 郑良彬 一锅法合成16-β甲基甾体化合物的方法

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WO2019129309A1 (fr) 2019-07-04

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Application publication date: 20180515

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