CN108026593A - 区分hiv-1与慢病毒载体的方法 - Google Patents

区分hiv-1与慢病毒载体的方法 Download PDF

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Publication number
CN108026593A
CN108026593A CN201680042304.1A CN201680042304A CN108026593A CN 108026593 A CN108026593 A CN 108026593A CN 201680042304 A CN201680042304 A CN 201680042304A CN 108026593 A CN108026593 A CN 108026593A
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CN
China
Prior art keywords
nucleic acid
hiv
probe
seq
slow virus
Prior art date
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Pending
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CN201680042304.1A
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English (en)
Chinese (zh)
Inventor
K·铃木
A·D·凯莱赫
G·P·西蒙兹
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Karin Samuel Australian Private Ltd
NewSouth Innovations Pty Ltd
St Vincents Hospital Sydney Ltd
Karin Muse Ltd By Share Ltd
Original Assignee
Karin Samuel Australian Private Ltd
NewSouth Innovations Pty Ltd
St Vincents Hospital Sydney Ltd
Karin Muse Ltd By Share Ltd
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Filing date
Publication date
Application filed by Karin Samuel Australian Private Ltd, NewSouth Innovations Pty Ltd, St Vincents Hospital Sydney Ltd, Karin Muse Ltd By Share Ltd filed Critical Karin Samuel Australian Private Ltd
Publication of CN108026593A publication Critical patent/CN108026593A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN201680042304.1A 2015-05-18 2016-05-16 区分hiv-1与慢病毒载体的方法 Pending CN108026593A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562163327P 2015-05-18 2015-05-18
US62/163,327 2015-05-18
PCT/US2016/032767 WO2016187151A1 (en) 2015-05-18 2016-05-16 Methods of discriminating between hiv-1 and lentiviral vectors

Publications (1)

Publication Number Publication Date
CN108026593A true CN108026593A (zh) 2018-05-11

Family

ID=56121165

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680042304.1A Pending CN108026593A (zh) 2015-05-18 2016-05-16 区分hiv-1与慢病毒载体的方法

Country Status (10)

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US (2) US10240214B2 (ru)
EP (1) EP3283658B1 (ru)
JP (1) JP2018516594A (ru)
CN (1) CN108026593A (ru)
AU (1) AU2016265839A1 (ru)
CA (1) CA2986133A1 (ru)
DK (1) DK3283658T3 (ru)
ES (1) ES2784351T3 (ru)
HK (1) HK1247965A1 (ru)
WO (1) WO2016187151A1 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210180106A1 (en) * 2016-02-12 2021-06-17 Curevac Ag Method for analyzing rna
US11920174B2 (en) 2016-03-03 2024-03-05 CureVac SE RNA analysis by total hydrolysis and quantification of released nucleosides
CN115768899A (zh) * 2020-03-09 2023-03-07 詹森生物科技公司 用于定量重组载体核酸整合的组合物和方法
CN111961760A (zh) * 2020-09-02 2020-11-20 苏州市第五人民医院 基于ddPCR自动化检测HIV-1的引物组、探针组、试剂盒及用途
CN114134251A (zh) * 2020-09-04 2022-03-04 西比曼生物科技（香港）有限公司 一种快速检测慢病毒载体滴度的方法
CN112210625A (zh) * 2020-11-02 2021-01-12 中山大学达安基因股份有限公司 定量检测人类免疫缺陷病毒1型dna载量的试剂盒及方法
CN113151587A (zh) * 2021-01-28 2021-07-23 云舟生物科技（广州）有限公司 一种慢病毒滴度检测引物、试剂盒及检测方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1169161A (zh) * 1994-10-07 1997-12-31 东卡罗来纳大学 减毒病毒及其制备方法
CN1348496A (zh) * 1999-02-12 2002-05-08 斯特拉思曼股份两合公司 病毒疫苗
WO2011008348A2 (en) * 2009-07-15 2011-01-20 Calimmune Inc. Dual vector for inhibition of human immunodeficiency virus
CN103882062A (zh) * 2014-03-13 2014-06-25 山西大学 慢病毒干扰载体pll3.7-Neo及其构建方法

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US4000159A (en) 1974-06-28 1976-12-28 Phillips Petroleum Company Preparation of n,n-disubstituted thioamides
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US5176995A (en) 1985-03-28 1993-01-05 Hoffmann-La Roche Inc. Detection of viruses by amplification and hybridization
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
ATE141956T1 (de) * 1989-07-11 1996-09-15 Gen Probe Inc Verfahren zur vervielfältigung von nukleinsäuresequenzen
WO1992020813A1 (en) * 1991-05-17 1992-11-26 Dana Farber Cancer Institute Assays for factors affecting circularization of dna, assays for factors affecting dna integration, factors, and uses thereof
US5578444A (en) * 1991-06-27 1996-11-26 Genelabs Technologies, Inc. Sequence-directed DNA-binding molecules compositions and methods
US5576176A (en) * 1994-03-03 1996-11-19 The Regents Of The University Of California Marker and an assay for detection and monitoring of human immunodeficiency virus latency and activation
JP5122957B2 (ja) * 2005-08-16 2013-01-16 タカラバイオ株式会社 免疫不全ウイルス感染症の治療または予防のための核酸
DK2456786T4 (en) 2009-07-24 2017-08-07 Immune Design Corp LENTIVIRUS VECTORS DETERMINED PSEUDOTYPE WITH A COAT PEGYCLOPROTEIN FROM SINDBIS VIRUS
EP3632463A1 (en) * 2011-04-08 2020-04-08 Immune Design Corp. Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
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Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1169161A (zh) * 1994-10-07 1997-12-31 东卡罗来纳大学 减毒病毒及其制备方法
CN1348496A (zh) * 1999-02-12 2002-05-08 斯特拉思曼股份两合公司 病毒疫苗
WO2011008348A2 (en) * 2009-07-15 2011-01-20 Calimmune Inc. Dual vector for inhibition of human immunodeficiency virus
CN103882062A (zh) * 2014-03-13 2014-06-25 山西大学 慢病毒干扰载体pll3.7-Neo及其构建方法

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* Cited by examiner, † Cited by third party
Title
BRYAN BURKE等: "CCR5 as a Natural and Modulated Target for Inhibition of HIV", 《VIRUSES》 *
BRYAN P BURKE等: "Engineering Cellular Resistance to HIV-1 Infection In Vivo Using a Dual Therapeutic Lentiviral Vector", 《MOLECULAR THERAPY-NUCLEIC ACIDS》 *
DATABASE EMBL: "CS108612", 《DATABASE EMBL》 *
MIYOSHI H等: "DEVELOPMENT OF A SELF-INACTIVATING LENTIVIRUS VECTOR", 《JOURNAL OF VI ROLOGY》 *
ORIT WOLSTEIN等: "Preclinical safetyand efficacy of an anti-HIV-1 lentiviralvector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor", 《MOLECULAR THERAPY -METHODS & CLINICAL DEVELOPMENT》 *

Also Published As

Publication number Publication date
US20180066325A1 (en) 2018-03-08
US11008630B2 (en) 2021-05-18
ES2784351T3 (es) 2020-09-24
US20190153551A1 (en) 2019-05-23
AU2016265839A1 (en) 2017-12-07
HK1247965A1 (zh) 2018-10-05
CA2986133A1 (en) 2016-11-24
JP2018516594A (ja) 2018-06-28
US10240214B2 (en) 2019-03-26
EP3283658A1 (en) 2018-02-21
EP3283658B1 (en) 2020-03-11
WO2016187151A1 (en) 2016-11-24
DK3283658T3 (da) 2020-05-18

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Application publication date: 20180511