CN108025055B - 多价肠道病毒疫苗组合物及其相关用途 - Google Patents

多价肠道病毒疫苗组合物及其相关用途 Download PDF

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Publication number
CN108025055B
CN108025055B CN201680034539.6A CN201680034539A CN108025055B CN 108025055 B CN108025055 B CN 108025055B CN 201680034539 A CN201680034539 A CN 201680034539A CN 108025055 B CN108025055 B CN 108025055B
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hrv
inactivated
dose
virus
serotype
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Chinese (zh)
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CN108025055A (zh
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马丁·L·摩尔
李秀振
阮明壮
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Emory University
Children's Healthcare of Atlanta
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Emory University
Children's Healthcare of Atlanta
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201680034539.6A 2015-06-15 2016-06-15 多价肠道病毒疫苗组合物及其相关用途 Expired - Fee Related CN108025055B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562175832P 2015-06-15 2015-06-15
US62/175,832 2015-06-15
PCT/US2016/037658 WO2016205389A1 (en) 2015-06-15 2016-06-15 Multivalent enterovirus vaccine compositions and uses related thereto

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CN108025055A CN108025055A (zh) 2018-05-11
CN108025055B true CN108025055B (zh) 2022-08-26

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Country Link
US (1) US11160857B2 (cg-RX-API-DMAC7.html)
EP (1) EP3307311A4 (cg-RX-API-DMAC7.html)
JP (2) JP6902195B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180086180A (cg-RX-API-DMAC7.html)
CN (1) CN108025055B (cg-RX-API-DMAC7.html)
CA (1) CA2989332A1 (cg-RX-API-DMAC7.html)
WO (1) WO2016205389A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016205389A1 (en) * 2015-06-15 2016-12-22 Emory University Multivalent enterovirus vaccine compositions and uses related thereto
CN109337876A (zh) * 2018-10-15 2019-02-15 北京世纪元亨动物防疫技术有限公司 一种猪流行性腹泻病毒的纯化方法
JP2022521410A (ja) * 2019-02-21 2022-04-07 センティヴァックス， インコーポレイテッド 最適化されたワクチン組成物およびその製造方法
CN115869324B (zh) * 2022-12-30 2024-02-27 湖北工业大学 Efavirenz在制备抗肠道病毒药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102089003A (zh) * 2008-03-27 2011-06-08 赛诺菲巴斯德生物制剂公司 重组鼻病毒载体
CN102917731A (zh) * 2010-05-26 2013-02-06 西莱克塔生物科技公司 多价的合成纳米载体疫苗
WO2014204303A2 (en) * 2013-06-17 2014-12-24 De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport Methods for the prevention of aggregation of viral components

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4946676A (en) 1986-08-27 1990-08-07 De Staat Der Nederlanden Vaccine comprising an immunogenic protein and, as an adjuvant, a substantially non-immunogenic, sequentially homologous peptide
US5714374A (en) 1990-09-12 1998-02-03 Rutgers University Chimeric rhinoviruses
US20020086386A1 (en) * 1997-03-04 2002-07-04 Kamb Carl Alexander B-catenin assays, and compositions therefrom
US20060088549A1 (en) 2004-07-08 2006-04-27 Arnold Gail F Chimeric virus vaccine
US8153760B2 (en) 2005-01-19 2012-04-10 Donald Danforth Plant Science Center Rhinovirus vaccines
EP2548573A1 (en) * 2006-09-29 2013-01-23 Sanofi Pasteur Biologics, LLC Novel neutralizing immunogen (NIMIV) of Rhinovirus and its use for vaccine applications
EP2414520A2 (en) * 2009-03-31 2012-02-08 Altair Therapeutics, Inc. Methods of modulating an immune response to a viral infection
EP2765137A1 (en) 2013-02-07 2014-08-13 Sanofi Pasteur Induction of cross-reactive cellular response against rhinovirus antigens
JP6774149B2 (ja) * 2014-05-28 2020-10-21 ナショナル ヘルス リサーチ インスティテューツＮａｔｉｏｎａｌ Ｈｅａｌｔｈ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅｓ エンテロウイルス感染に対する免疫原としてのウイルス粒子およびその生産
WO2016205389A1 (en) * 2015-06-15 2016-12-22 Emory University Multivalent enterovirus vaccine compositions and uses related thereto

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102089003A (zh) * 2008-03-27 2011-06-08 赛诺菲巴斯德生物制剂公司 重组鼻病毒载体
CN102917731A (zh) * 2010-05-26 2013-02-06 西莱克塔生物科技公司 多价的合成纳米载体疫苗
WO2014204303A2 (en) * 2013-06-17 2014-12-24 De Staat Der Nederlanden, Vert. Door De Minister Van Vws, Ministerie Van Volksgezondheid, Welzijn En Sport Methods for the prevention of aggregation of viral components

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Developing a vaccine for human rhinoviruses;Gary R McLean;《J Vaccines Immun.》;20150113;第2卷(第3期);第1-10页 *
Human Responses to Two Decavalent Rhinovims Vaccines;Bruce H.Hamory;《THE JOURNAL OF INFECTIOUS DISEASE》;19751231;第132卷(第6期);第623-629页 *

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Publication number Publication date
EP3307311A1 (en) 2018-04-18
CN108025055A (zh) 2018-05-11
JP2021152024A (ja) 2021-09-30
JP6902195B2 (ja) 2021-07-14
US11160857B2 (en) 2021-11-02
EP3307311A4 (en) 2019-02-13
WO2016205389A1 (en) 2016-12-22
US20180169215A1 (en) 2018-06-21
CA2989332A1 (en) 2016-12-22
JP2018517722A (ja) 2018-07-05
KR20180086180A (ko) 2018-07-30

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