CN108025046B - 结合cd3和肿瘤抗原的异二聚体抗体 - Google Patents

结合cd3和肿瘤抗原的异二聚体抗体 Download PDF

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CN108025046B
CN108025046B CN201680040299.0A CN201680040299A CN108025046B CN 108025046 B CN108025046 B CN 108025046B CN 201680040299 A CN201680040299 A CN 201680040299A CN 108025046 B CN108025046 B CN 108025046B
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antibody
scfv
sequence
variants
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CN108025046A (zh
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G·摩尔
J·德拉莱斯
M·贝尔尼特
S·楚
R·拉什德
U·穆赫哈
S-H·李
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Xencor Inc
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    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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CN201680040299.0A 2015-05-08 2016-04-28 结合cd3和肿瘤抗原的异二聚体抗体 Active CN108025046B (zh)

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US201562159111P 2015-05-08 2015-05-08
US62/159,111 2015-05-08
US201562251005P 2015-11-04 2015-11-04
US201562250971P 2015-11-04 2015-11-04
US62/250,971 2015-11-04
US62/251,005 2015-11-04
US14/952,714 US10889653B2 (en) 2014-11-26 2015-11-25 Heterodimeric antibodies that bind CD3 and tumor antigens
USPCT/US2015/062772 2015-11-25
PCT/US2015/062772 WO2016086189A2 (en) 2014-11-26 2015-11-25 Heterodimeric antibodies that bind cd3 and tumor antigens
US14/952,714 2015-11-25
PCT/US2016/029797 WO2016182751A1 (en) 2015-05-08 2016-04-28 Heterodimeric antibodies that bind cd3 and tumor antigens

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