CN108024952A - 在治疗发作中用于口颊施用以获得快速起效的咪达唑仑组合物 - Google Patents

在治疗发作中用于口颊施用以获得快速起效的咪达唑仑组合物 Download PDF

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Publication number
CN108024952A
CN108024952A CN201680041767.6A CN201680041767A CN108024952A CN 108024952 A CN108024952 A CN 108024952A CN 201680041767 A CN201680041767 A CN 201680041767A CN 108024952 A CN108024952 A CN 108024952A
Authority
CN
China
Prior art keywords
film forming
forming matter
cellulose
dosage composition
midazolam
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680041767.6A
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English (en)
Chinese (zh)
Inventor
克里斯特·斯约根
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smart Co Ltd
Original Assignee
Smart Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smart Co Ltd filed Critical Smart Co Ltd
Publication of CN108024952A publication Critical patent/CN108024952A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680041767.6A 2015-07-16 2016-07-15 在治疗发作中用于口颊施用以获得快速起效的咪达唑仑组合物 Pending CN108024952A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201570475 2015-07-16
DKPA201570475 2015-07-16
PCT/EP2016/066860 WO2017009446A1 (en) 2015-07-16 2016-07-15 Compositions of midazolam for buccal administration in the treatment of seizures to obtain rapid onset of action

Publications (1)

Publication Number Publication Date
CN108024952A true CN108024952A (zh) 2018-05-11

Family

ID=53785375

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680041767.6A Pending CN108024952A (zh) 2015-07-16 2016-07-15 在治疗发作中用于口颊施用以获得快速起效的咪达唑仑组合物

Country Status (6)

Country Link
US (2) US20180221384A1 (enExample)
EP (1) EP3322402B1 (enExample)
JP (1) JP2018521139A (enExample)
CN (1) CN108024952A (enExample)
ES (1) ES2738652T3 (enExample)
WO (1) WO2017009446A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102021105268A1 (de) * 2021-03-04 2022-09-08 Lts Lohmann Therapie-Systeme Ag. Oraler Dünnfilm
EP4392015A1 (en) 2021-08-25 2024-07-03 Swipp Ab Oral film unit dosage form
WO2024180208A1 (en) 2023-03-01 2024-09-06 Swipp Ab Oral film unit dosage form
WO2024180209A1 (en) 2023-03-01 2024-09-06 Swipp Ab Crystalline form of midazolam hydrochloride

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009989A1 (en) * 1997-08-21 1999-03-04 R. P. Scherer Limited Pharmaceutical composition containing midazolam
CN1764436A (zh) * 2003-03-26 2006-04-26 宝洁公司 薄膜强度和稳定性得到改进的迅速溶解的可食用薄膜组合物
CN1830447A (zh) * 2006-04-02 2006-09-13 岳振江 马来酸咪达唑仑口服膜剂及其制备方法
CN102892815A (zh) * 2010-03-26 2013-01-23 陶氏环球技术有限责任公司 熔体挤出的膜
CN102933207A (zh) * 2009-10-30 2013-02-13 Ix生物医药私人有限公司 快速溶解固体剂型

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264981B1 (en) * 1999-10-27 2001-07-24 Anesta Corporation Oral transmucosal drug dosage using solid solution
CA2535846A1 (en) * 2003-08-15 2005-02-24 Qlt Usa, Inc. Adhesive bioerodible transmucosal drug delivery system

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009989A1 (en) * 1997-08-21 1999-03-04 R. P. Scherer Limited Pharmaceutical composition containing midazolam
CN1764436A (zh) * 2003-03-26 2006-04-26 宝洁公司 薄膜强度和稳定性得到改进的迅速溶解的可食用薄膜组合物
CN1830447A (zh) * 2006-04-02 2006-09-13 岳振江 马来酸咪达唑仑口服膜剂及其制备方法
CN102933207A (zh) * 2009-10-30 2013-02-13 Ix生物医药私人有限公司 快速溶解固体剂型
CN102892815A (zh) * 2010-03-26 2013-01-23 陶氏环球技术有限责任公司 熔体挤出的膜

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
R. SCHWAGMEIER等: "Midazolam pharmacokinetics following intravenous and buccal administration", 《BRITISH JOURNAL OF CLINICAL PHARMACOLOGY》 *
颜耀东: "《缓释控释制剂的设计与开发》", 30 June 2006, 北京：中国医药科技出版社 *

Also Published As

Publication number Publication date
US20200306260A1 (en) 2020-10-01
JP2018521139A (ja) 2018-08-02
EP3322402A1 (en) 2018-05-23
US20180221384A1 (en) 2018-08-09
ES2738652T3 (es) 2020-01-24
EP3322402B1 (en) 2019-05-29
WO2017009446A1 (en) 2017-01-19

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SE01 Entry into force of request for substantive examination
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Application publication date: 20180511