CN108003112A - 一种杂环脲类吲哚胺-2,3-双加氧酶抑制剂中间体制备方法 - Google Patents
一种杂环脲类吲哚胺-2,3-双加氧酶抑制剂中间体制备方法 Download PDFInfo
- Publication number
- CN108003112A CN108003112A CN201711409931.7A CN201711409931A CN108003112A CN 108003112 A CN108003112 A CN 108003112A CN 201711409931 A CN201711409931 A CN 201711409931A CN 108003112 A CN108003112 A CN 108003112A
- Authority
- CN
- China
- Prior art keywords
- compound
- heterocyclic urea
- preparation
- indoles amine
- dioxygenase inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711409931.7A CN108003112B (zh) | 2017-12-23 | 2017-12-23 | 一种杂环脲类吲哚胺-2,3-双加氧酶抑制剂中间体制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711409931.7A CN108003112B (zh) | 2017-12-23 | 2017-12-23 | 一种杂环脲类吲哚胺-2,3-双加氧酶抑制剂中间体制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108003112A true CN108003112A (zh) | 2018-05-08 |
CN108003112B CN108003112B (zh) | 2021-03-19 |
Family
ID=62060781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711409931.7A Active CN108003112B (zh) | 2017-12-23 | 2017-12-23 | 一种杂环脲类吲哚胺-2,3-双加氧酶抑制剂中间体制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108003112B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113173872A (zh) * | 2021-03-29 | 2021-07-27 | 龙曦宁(上海)医药科技有限公司 | 一种丁醚脲杂质c的合成方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2172198A1 (en) * | 2007-07-20 | 2010-04-07 | Chugai Seiyaku Kabushiki Kaisha | p27 PROTEIN INDUCER |
CN103524542A (zh) * | 2012-09-17 | 2014-01-22 | 天津雅特生物科技有限公司 | 一种氨基苯硼酸频哪醇酯的制备方法 |
WO2014120748A1 (en) * | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
CN106967004A (zh) * | 2017-03-29 | 2017-07-21 | 中国药科大学 | 含脲基的ido1和ido2双重抑制剂、其制法及其医药用途 |
-
2017
- 2017-12-23 CN CN201711409931.7A patent/CN108003112B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2172198A1 (en) * | 2007-07-20 | 2010-04-07 | Chugai Seiyaku Kabushiki Kaisha | p27 PROTEIN INDUCER |
CN103524542A (zh) * | 2012-09-17 | 2014-01-22 | 天津雅特生物科技有限公司 | 一种氨基苯硼酸频哪醇酯的制备方法 |
WO2014120748A1 (en) * | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
CN106967004A (zh) * | 2017-03-29 | 2017-07-21 | 中国药科大学 | 含脲基的ido1和ido2双重抑制剂、其制法及其医药用途 |
Non-Patent Citations (1)
Title |
---|
陈启凡 等: "3-氨基-4-氨基肟基呋咱的绿色合成工艺", 《辽东学院学报(自然科学版)》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113173872A (zh) * | 2021-03-29 | 2021-07-27 | 龙曦宁(上海)医药科技有限公司 | 一种丁醚脲杂质c的合成方法 |
CN113173872B (zh) * | 2021-03-29 | 2023-09-26 | 龙曦宁(上海)医药科技有限公司 | 一种丁醚脲杂质c的合成方法 |
Also Published As
Publication number | Publication date |
---|---|
CN108003112B (zh) | 2021-03-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN111423452B (zh) | 瑞卢戈利的中间体及其制备方法和应用 | |
US8598222B2 (en) | Method for preparing 1,3,4-substituted pyrazol compounds | |
CN108570041B (zh) | 一种含异恶唑啉脲嘧啶类化合物的制备方法 | |
CN106588897A (zh) | 一种普仑司特的新制备方法 | |
WO2014177517A1 (en) | Preparation process of an agonist of the thrombopoietin receptor | |
CN104725303A (zh) | 一种2-氯-n-(4′-氯联苯-2-基)烟酰胺的合成方法 | |
CN109320413A (zh) | 一种苯乙酸类化合物的制备方法 | |
CN105712984A (zh) | 一种阿齐沙坦的制备方法 | |
CN105418483A (zh) | 一种结晶型乙磺酸尼达尼布的制备方法 | |
CN108003112A (zh) | 一种杂环脲类吲哚胺-2,3-双加氧酶抑制剂中间体制备方法 | |
CN105218445B (zh) | 一种酪氨酸激酶抑制剂Foretinib的制备方法 | |
CN103012260B (zh) | 匹伐他汀钙中间体的制备方法 | |
CN104326975A (zh) | 一种高纯度米力农的制备方法 | |
CN115433140B (zh) | 一种阿福拉纳的合成方法 | |
CN104725321B (zh) | 一种嘧菌酯中间体的制备方法 | |
CN108610290B (zh) | 一种氟唑菌酰羟胺的制备方法 | |
CN107903209B (zh) | 一种2-氨基-5-氟吡啶-3-甲酸甲酯的合成方法 | |
CN109810066A (zh) | 一种盐酸氨溴索有关物质的合成方法 | |
CN110143945A (zh) | 一种4-取代基甲基-1-(2h)酞嗪酮的简便制备方法 | |
CN107868054A (zh) | 一种嘧菌酯中间体的制备方法 | |
CN105924400B (zh) | 阿齐沙坦杂质a和b的制备方法 | |
CN110563643A (zh) | 一种(5-溴-3-甲基-吡啶-2-基)-甲胺的合成方法 | |
CN107721941A (zh) | 一种3‑氨基‑5‑甲基异噁唑的制备方法 | |
CN109810052A (zh) | 一种高选择性的阿帕替尼的简便制备方法 | |
CN104529814A (zh) | 一种合成n-苄基羟胺盐酸盐的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information |
Inventor after: Gao Feng Inventor after: Zeng Sailan Inventor after: Pan Ruiliang Inventor after: Zhang Liuliu Inventor after: Jiang Junqiang Inventor after: Zhang Xingxing Inventor before: Gao Feng Inventor before: Zeng Sailan Inventor before: Jiang Junqiang Inventor before: Zhang Xingxing |
|
CB03 | Change of inventor or designer information | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20210225 Address after: 753000 No.8 workshop of Shizuishan science and Technology Industrial Park, Pingluo County, Shizuishan City, Ningxia Hui Autonomous Region Applicant after: NINGXIA LABSCHEM Co.,Ltd. Address before: 201512 room 404, unit 2, building 1, no.688 Qiushi Road, Jinshanwei Town, Jinshan District, Shanghai Applicant before: SHANGHAI TBBMED Co.,Ltd. |
|
TA01 | Transfer of patent application right | ||
GR01 | Patent grant | ||
GR01 | Patent grant |