CN107982159A - A kind of preparation method of longan extract - Google Patents
A kind of preparation method of longan extract Download PDFInfo
- Publication number
- CN107982159A CN107982159A CN201711459815.6A CN201711459815A CN107982159A CN 107982159 A CN107982159 A CN 107982159A CN 201711459815 A CN201711459815 A CN 201711459815A CN 107982159 A CN107982159 A CN 107982159A
- Authority
- CN
- China
- Prior art keywords
- extract
- longan
- deionized water
- cellulase
- fruit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/84—Products or compounds obtained by lyophilisation, freeze-drying
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of preparation method of longan extract, it uses pectase and the double enzymes of cellulase, and zymohydrolysis extracting method, specific preparation process are as follows at the same time：Fresh longan is after 80 DEG C of heated-air dryings, peeled and cored, obtains longan fruit jerky, and 4 DEG C of low temperature of sealing saves backup；Longan fruit jerky is weighed, adds deionized water immersion 12h, material-water ratio 1:3, smashed to pieces with high-speed tissue mashing machine；Stamping is taken to add deionized water, material-water ratio at this time is 1:12, digested using two kinds of enzymes of pectase and cellulase, calculated according to mass percent at the same time, pectin enzyme dosage 0.6%, cellulase dosage 0.05%, it is 3.1 to adjust pH value, 52 DEG C of hydrolysis temperature, enzymolysis time 160min, after enzymolysis, filtrate is collected by filtration in the enzyme deactivation 30min under the conditions of 90 DEG C, 200 mesh, half flowing slurry is concentrated the filtrate to, then by slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, up to longan extract.
Description
Technical field
The present patent application is November 30 2017 applying date, Application No.：201711240432X, entitled " one kind tool
Have the preparation method of the freeze-dried powder of the composition of acne-removing " application for a patent for invention divisional application.The invention belongs to daily
Skin care item preparing technical field, more particularly to a kind of preparation method of the freeze-dried powder of the composition with acne-removing.
Background technology
Whelk also known as acne, the generation of acne is mainly blocked with hypersteatosis, pilosebaceous duct, bacterium sense
Dye and the factor such as inflammatory reaction are closely related.Adolesce the rapid rise of level of the particularly emerald green ketone of androgen in descendant's body,
Sebaceous glands is promoted to develop and produce a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage, sebum row at the same time
Go out obstacle, form horn plug, that is, micro mist thorn.Multiple-microorganism especially propionibacterium acnes amount reproduction, acne propionic acid in hair follicle
The lipase that bacillus produces decomposes sebum generation free fatty, while chemotactic inflammatory cell and medium, finally induces and aggravates inflammation
Disease is reacted.
With the lifting of people's consumption consciousness, consumer increasingly focuses on product when cleaning product and skin care item are selected
Security, the security of product is much than therapeutic and esthetics itself is important more.Natural plants and the extraction of animal
Thing sensitization rate itself is very low, and security is very high, and the product that production is prepared using this kind of active component extract is also increasingly subject to
The attention of consumer and like.
Nano-graphene can kill 10 various bacteria such as Pseudomonas aeruginosa, Escherichia coli, this is because nano-graphene sheet
Body is the carbon atom to string, and just as one layer very thin very closely knit cloth, the mode that they tackle bacterium has three kinds：The first is
Directly cut, since graphene is nano level, and bacterium is micron order, the former is 1000 times smaller than the latter, and graphene is just as one
Very sharp knife, directly bacterium is cut to death；Second is bacterium hungry to death, and nano level graphene can be as cloth by bacterium
Closely wrap up, bacterium is absorbed less than nutrition, die of starvation；The third is slowly to wither away, since graphene is too small, carefully
Bacterium can gulp down graphene inner into " tripe ", can suffer from diarrhea uncomfortable just as people has eaten foreign matter, cause bacterium slowly to be withered away, exactly because
This physical sterilization method of graphene, allows bacterium not produce drug resistance, there is good acne-removing inflammation-diminishing effect to skin.
At present, many product for resolving poxes use the components such as hormone, antibiotic, vitamin A acid, and irritation is big, easily cause skin pair
The drug resistance of bacterium, security are constantly under suspicion.And such product does not have usually antibacterial and dispel long lasting for property
The ability that the effect of acne, no acne print and color spot are dispelled.
The content of the invention
For overcome the deficiencies in the prior art, it is an object of the present invention to provide a kind of composition and its jelly with acne-removing
The preparation method of dry powder, the product that effectively can solve to produce at present are carried for the fruit active material of performance drug effect
Take it is inefficient, containing preservative, hormone injury skin, make skin produce drug resistance, and oxidation resistance is weak cannot be effective
Prevent the problem of formation of pockmark and acne scar.
The present invention is achieved by the following technical solution：
A kind of composition with acne-removing, it is characterised in that being calculated according to weight fraction includes following component：Traditional Chinese medicine extraction
10-15 parts of thing, 3-5 parts of climbing fig syconium extract, 3-5 parts of Fructus Monordicae extract, 4-6 parts of indigo berry extract, Guangxi Folium hydrangeae strigosae
2-4 parts of berry extract, 6-8 parts of mango extract, 6-8 parts of longan extract, 10-12 parts of apple extract, nano-graphene 0.5
Part, 0.01 part of fibroblast growth factor, -2 parts of dextran 1,0.05-0.1 parts of polyglutamic acid, 2-4 parts of mannitol, go from
Sub- water 65-85 parts；The Chinese medical extract is according to weight fraction meter, its component：5 parts of licorice, Radix Salviae Miltiorrhizae extraction
5 parts of thing；
The preparation method of the longan extract is specific to prepare using pectase and the double enzymes of cellulase while zymohydrolysis extracting method
Method is as follows：Fresh longan is after 80 DEG C of heated-air dryings, peeled and cored, obtains longan fruit jerky, and sealing 4 DEG C of preservations of low temperature are standby
With；Longan fruit jerky is weighed, adds deionized water immersion 12h, material-water ratio 1:3, smashed to pieces with high-speed tissue mashing machine；Take and smash to pieces
Thing adds deionized water, and material-water ratio at this time is 1:12, digested at the same time using two kinds of enzymes of pectase and cellulase, according to quality
Percentage calculates, pectin enzyme dosage 0.6%, cellulase dosage 0.05%, and it is 3.1 to adjust pH value, 52 DEG C of hydrolysis temperature, enzymolysis
Time 160min, after enzymolysis, filtrate is collected by filtration in the enzyme deactivation 30min under the conditions of 90 DEG C, 200 mesh, concentrates the filtrate to half
Slurry is flowed, then by slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, up to longan extract.
Further, the preparation method of the Guangxi Folium hydrangeae strigosae berry extract is as follows：Weigh Guangxi Folium hydrangeae strigosae pericarp meat and be placed in and grind
In alms bowl, it is transferred to completely in tool plug container after adding the grinding of 85% methanol solution, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W,
50 min of ultrasonic extraction, room temperature cooling, 10 min are centrifuged by extracting solution under 4500 rpm/min rotating speeds；Will centrifugation gained upper strata
After clear liquid is concentrated into half flowing slurry, by slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and are obtained extensively
Western Sweet tea berry extract.
Further, the preparation method of the climbing fig syconium extract, Fructus Monordicae extract and apple extract is wrapped
Include following steps：The pericarp and pulp of liquid nitrogen grinding into the various raw materials of powder are separately added into 90% ethanol solution, solid-to-liquid ratio 1:
33, under the conditions of 31 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 38min, obtains extracting solution；Extracting solution filtering is concentrated under reduced pressure,
Obtain slurry；By slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and are respectively obtained climbing fig syconium and are carried
Take thing, Fructus Monordicae extract and apple extract.
Further, the preparation method of the indigo berry extract is as follows：Indigo fruit surface silt is washed away with circulating water, will
Ozone generator is passed through in sterile water cleans indigo fruit again, drains stoning afterwards, and pulp is crushed and breaks into pulp, afterwards by fruit
Volume of slurry is 40% addition deionized water, while adds pectase 3.5%, stands 30 min after stirring and evenly mixing under the conditions of 35 DEG C；
Supernatant liquor after standing is added into 95% ethanol solution, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction
15min, 10 min are centrifuged under 4000 rpm/min rotating speeds；After centrifugation gained supernatant liquor is concentrated into half flowing slurry,
By slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and obtain indigo berry extract.
Further, the preparation method of the mango extract is specific as follows：Weigh mango pulp and pericarp freeze dried powder
End, adds 80% acetone, the above two solid-to-liquid ratio is 1:20, ultrasonic extraction 30 min, supersonic frequency 60kHz, power 30W,
10 min are centrifuged under conditions of 7000rpm/min, take supernatant, are repeated twice aforesaid operations, merge supernatant；After merging
Supernatant on Rotary Evaporators in being evaporated, and the product obtained after being evaporated is with 1：10 volume ratios are dissolved in deionized water, agitated,
Shake up, obtain mango extract.
A kind of preparation method of the freeze-dried powder of the composition with acne-removing, it is characterised in that include the following steps：
Step 1：Polyglutamic acid and deionized water are proportionally put into homogenizer, homogeneous 10min, complete under the conditions of 78 DEG C
Fully dissolved obtains A, places A Temperature falls afterwards；
Step 2：Mannitol and dextran are proportionally added when the temperature of A is down to 50 DEG C or so, is uniformly mixed and obtains B；
Step 3：30 DEG C or so, which are down to, when the temperature of B is proportionally added into Chinese medical extract, climbing fig syconium extract, Siraitia grosvenorii
Extract, indigo berry extract, Guangxi Folium hydrangeae strigosae berry extract, mango extract, longan extract, apple extract, nanometer stone
Black alkene, fibroblast growth factor are uniformly mixing to obtain C, C then are freezed 20h at -25 DEG C, to discharging after version qualification；
Step 4：C that freezing processing is crossed is filling to be placed in vacuum freeze, in -50 DEG C, the bar of vacuum 7Pa
Vacuum freeze drying processing 35h is carried out under part and obtains the freeze-dried powder of the composition with acne-removing containing the present invention.
Climbing fig is a kind of to have edible, medicinal and the ecological value evergreen liana concurrently.Climbing fig syconium is full of nutrition, achene and
The positions such as perianth are containing abundant nutritional ingredient.Content of fatty acid is very high in achene, up to 30.13%, predominantly unsaturated fat
Sour such as a- leukotrienes, linoleic acid;In addition, also containing abundant crude fibre (33.4%), protein (15.7%) and pectin
(15.15%) etc.;Amino acid analysis is shown, 17 kinds of amino acid, wherein content of glutamic acid highest, and human body are contained in climbing fig achene
Required 8 kinds of amino acid is various, and various mineral elements and vitamin content are also compared with horn of plenty.Modern research shows that climbing fig syconium
Containing multiple compounds such as flavonoids, triterpenes, cumarin, glycosides, there is fabulous antioxidation activity, antibacterial activity, dispels
The effect of wind dehumidifying, promoting blood circulation and removing obstruction in channels, subdhing swelling and detoxicating, anti-inflammatory, it is often more important that contain former delphinidin, the component in climbing fig syconium
And a kind of natural stabilizer, the stabilizer in material system without additionally addition industrial goods, it is possible to while utilize Pi
The natural anti-inflammatory, antibacterial antioxidant material of litchi syconium utilizes it as the effect of natural stabiliser again.
Siraitia grosvenorii is the fruit of Dicotyledoneae Curcurbitaceae Genus Siraitia Merr, vegetable formal name " Semen Momordicae ".Arhat
Berry extract and isolated component from Siraitia grosvenorii have clearing heat and detoxicating, antibechic clearing lung-heat, antibacterial anti-inflammatory, strengthen immune etc. make
With.Main active ingredient be mogroside its be cucurbitane element triterpene sweet tea glycoside compound.Momordica grosvenori polysaccharide and mogroside
It is antiviral with antibacterial, radiation resistance.Also contain glycosides displayed and protein amino acids in Siraitia grosvenorii, contain 17 kinds of amino
Sour component and 16 kinds of inorganic microelements, and VC contents it is more taller than Kiwi berry go out it is very much, be a kind of crude drug full of nutrition
Fruit.
Indigo fruit category Caprifoliaceae, is a kind of wild acinus class plant, and seed is minimum, and crushing juice rate is high, contains abundant ammonia
Base acid, vitamin and bioactive substance, have superior antioxidation activity, healthy nutritive value is high.Anthocyanin and flavones
Class compound has some beneficial physiological functions and pharmacological action, wherein pattern as the functional component in indigo fruits
Glycosides, which has, eliminates free radical, anti-aging, anti-oxidant, and anti-inflammatory and the function of improving immunity, flavone compound can promote human body
Interior blood circulation, amino acid, vitamin and anthocyanin and Flavonoid substances collective effect can effectively hinder in anti-inflammatory, promotion
Mouth healing, prevent scar from generating.Amino acid, vitamin and anthocyanin in indigo fruit can equally utilize other plant of the present invention
With effective flavones ingredient anti-inflammatory in fruit extract, it is anti-oxidant, promote wound healing, prevent scar generation play collaboration increase
The effect of effect.
Guangxi Folium hydrangeae strigosae is a new varieties for rose family rubus plant, is the distinctive plant in Guangxi.Sweet tea fruit its
Full of nutrition and complete, fruit soft and succulency, color and luster is pleasant, because of sweet tea in fact fragrance it is full of nutrition be processed into jam, fruit juice,
The products such as fruit wine.Fruit is medicinal, energy improving eyesight, kidney tonifying, qi-regulating of calming the nerves.Recent studies indicate that Sweet tea berry extract contain it is abundant
Terpenoid and volatile oil component, wherein main component is Quercetin and kaempferol, both components all have good
Antibacterial, the effect of anti-inflammatory, has good therapeutic effect for acne, small pox skin, while Sweet tea fruit extract is also a kind of
Natural preservative, without especially add preservative in raw material of the invention.
Mango is a kind of aiphyllium of original India, leaf keratin, alternate；It is warm-natured, small, yellow or pale red are spent, into top
Raw panicle.Mango Fruit contains sugar, protein, crude fibre, the precursor carrotene of the vitamin A contained by mango into
Dtex is not high, is rare in all fruit.Secondly Vitamin C content is not also low.Mineral matter, protein, fat, carbohydrate etc.,
And its main nutrient composition.Mango is one of famous tropical fruit (tree), and because its pulp is fine and smooth, unique flavor, is favored by people,
So the reputation for being known as " tropical fruit king " claims.Most unique and most important component in Mango Fruit extract is mangiferin, mango
Glycosides is polyphenol compound important in mango, belong to xanthone compound, mangiferin have efficient anti-inflammatory, immunological regulation with
And oxidation resistant effect, for skin inflammation have it is good and the effect of stablize.
Longan is the famous subtropical fruit in China, and fruit popular name longan, it is " fruit Zisco product " to be praised highly by people.Longan is sought
One of very high and important medicinal material of foster value.There is abundant phospholipid fraction in arillus longan：Total phospholipids (mg/g) 3.95 ±
0.12, lysophosphatide phthalein choline 13.8, phospholipid acid choline 49. 5, phosphatide phthalein inositol 2.4, phosphatide phthalein serine 3.8, phosphatide phthalein
Monoethanolamine 3.8, phosphatidic acid 2.8, phosphatide phthalein glycerine 19.7, mentioned component is to skin anti-aging, increase body's immunity etc.
Aspect has stronger effect.Meanwhile the component in longan pulp also containing abundant polysaccharide, polyphenol alcohols and terpenoid,
Most important one component is panaxoside, which has the function that efficient anti-inflammatory, removing toxic substances and promote cell growth.Can be with
Act synergistically with other antimicrobial components in the present invention so that the antimicrobial antiphlogistic effect of product of the present invention greatly promotes.
Apple is one of ten big fruit of the world, and apple has very high health value, and apple aldehydes matter is to influence apple
A kind of important substance of health-care effect.Aldehydes matter is one of naturally occurring important secondary metabolites, is important day
Right antioxidant source.Apple is rich in sugar, protein, organic acid, vitamin and a variety of phenols components, wherein anthocyanin,
Phenolic acid and flavonoid substances are phenols components main in apple.Investigated according to nutritionists such as Holland, the U.S., apple is to be located at
The third-largest aldehydes matter dietary source after tea and onion.Many pharmacological researches show that the aldehydes matter in apple, has more
Kind bioactivity, can remove oxygen radical excessive in vivo, there is very strong antioxidant effect.Apple extract can effectively drop
Low capillary vasopermeability, the microcirculation for improving skin surface, wound healing and scar desalination.Apple extract is in itself
A kind of and preservative.
Radix glycyrrhizae is known as the title of whitening queen, suppresses the activity of tyrosinase while its extract uvioresistant, moreover it is possible to change
The problems such as kind pachylosis, water shortage inflammation.Its whitening function active ingredient is flavone compound such as liquiritin, glycyrrhizin,
Enoxolone, glycyrrhizin and some polysaccharose substances.Result of study is found, tyrosinase activity is pressed down when radix glycyrrhizae is used alone
Rate processed is very low, and compound increases 5-6 times to inhibitory activity against tyrosinase.
Radix Salviae Miltiorrhizae chemical composition mainly has the fat-soluble diterpene-kind compound such as tanshinone, water-soluble phenolic acids material for example red
Ginseng element, danshinolic acid and some polysaccharose substances.It removes free radical antioxygen when licorice and Salvia root P.E are used alone
Change ability is weaker, and photostability is very poor, but licorice and Salvia root P.E it is compound have more preferable photostability and
The antioxygenic property more increased into multiple.Composite extract can produce people's dermal fibroblasts and people's epidermal keratinocyte propagation
Raw material impact, the extract of compound use can promote the propagation of people's dermal fibroblasts, boost metabolism, and suppress people
Epidermal keratinocyte is bred, cutin-softening layer, promotes wound healing, will not produce stimulation to skin.Licorice and
The composite extract of Salvia root P.E can be well suppression butyric acid enzymatic activity.That is licorice and Radix Salviae Miltiorrhizae extraction
The compounding use of thing and nano-graphene can be greatly improved suppresses synergistic effect and anti-inflammatory for tyrosinase activity
Activity.
Medicinal substances compatibility, which is used as medicine, in material in the present invention synergy to play antibacterial anti-inflammatory, the effect of anti-acne myogenic mutually
Fruit.Guangxi beet berry extract and apple extract can be cooperateed with to be collectively forming and more improve and effective anti-corrosion body again at the same time
System.
Fibroblast growth factor (Fibroblast growth factors, FGFs) is a kind of multi-functional non-spy
A variety of mesoderms such as specific activities material, Human Umbilical Vein Endothelial Cells, fibroblast and the cell in the outer embryo source of nerve, which have, promotes DNA to close
Into with promote fissional effect.FGFs also plays fibroblastic collage synthesis double regulation control effect:By to collagen
Continuous synthesis, secretion, reconstruction and renewal, and constantly improve and rehabilitate the structure and intensity of tissue, while clostridiopetidase A can be stimulated
Expression, therefore can effectively suppress the pathologic scar produced by a large amount of synthesis of collagen and excessive deposition, so as to improve
The quality of wound healing.
Nano-graphene can kill 10 various bacteria such as Pseudomonas aeruginosa, Escherichia coli, this is because nano-graphene sheet
Body is the carbon atom to string, and just as one layer very thin very closely knit cloth, the mode that they tackle bacterium has three kinds：The first is
Directly cut, since graphene is nano level, and bacterium is micron order, the former is 1000 times smaller than the latter, and graphene is just as one
Very sharp knife, directly bacterium is cut to death；Second is bacterium hungry to death, and nano level graphene can be as cloth by bacterium
Closely wrap up, bacterium is absorbed less than nutrition, die of starvation；The third is slowly to wither away, since graphene is too small, carefully
Bacterium can gulp down graphene inner into " tripe ", can suffer from diarrhea uncomfortable just as people has eaten foreign matter, cause bacterium slowly to be withered away, exactly because
This physical sterilization method of graphene, allows bacterium not produce drug resistance, there is good acne-removing inflammation-diminishing effect to skin.
The fruit component that will targetedly act on, nano-graphene and growth factor are used in combination, solution that can be more efficient
The problem of acne of certainly good skin is brought, while greatly improve antibacterial anti-inflammatory, anti-oxidant, promotion healing and the reparation of product
Performance.
There is the present invention composition of acne-removing and its preparation method of freeze-dried powder to have the advantages that：
1st, there is the present invention composition of acne-removing and its preparation method of freeze-dried powder to combine nano-graphene first, into fibre
The active ingredient in Porcine HGF and hjolomorphism natural fruit extract is tieed up, is prepared without preservative, stabilizer, it is stingless
Swash, continue antibacterial efficient anti-inflammatory, anti-acne, the freeze-dried powder for preventing pockmark and acne scar from being formed.The present invention is without any industrial goods preservative
Add, there is safe and non-toxic natural antiseptic agent, good water solubility, heat endurance is good, sphere of action is wide in component.
2nd, there is the present invention extract most in the composition of acne-removing and its preparation method of freeze-dried powder to use
Ultrasonic extraction carries, and the technique extraction efficiency is high, high for the active ingredient utilization rate in fruit medicine, does not waste money
Source.The present invention using ultrasonic extraction prepares extract, the judder that is produced using ultrasonic wave, higher acceleration, by force
The special effects such as strong cavitation effect, stirring, plant cell can be destroyed, solvent is penetrated into Materials Cell, promotes to wait to carry
Take the chemical composition in raw material to be dissolved in solvent, then required chemical composition is drawn by separating-purifying.Utilize ultrasonic wave extraction
30min will be higher by 9% than the recovery rate of conventional decocting method extraction 3h.
3rd, the present invention has the extraction of the composition of acne-removing and its a part of fruit in the preparation method of freeze-dried powder
Zymohydrolysis extracting method is used in the preparation method of thing, wherein the zymohydrolysis extracting method for having single kind also has the enzyme that a variety of enzymes are used in mixed way
Solve extraction method.Enzyme engineering technology is a biotechnology for being used for active ingredient of natural plant extraction in recent years.In life
In the extraction process of active substances, extraction conditions can be reduced using enzyme, plant tissue is decomposed in comparatively gentle condition, carries
High extracting efficiency.It has been effectively combined and has formd natural effective preservative system, without especially adding, pro-skin is non-stimulated,
Reduce cost.
4th, the present invention have acne-removing composition and its freeze-dried powder preparation method in and a variety of fruit extracts
For compound action system, its fully utilize longan extract headed by, climbing fig addiction berry extract and mango extract be auxiliary
Collaboration anti-inflammatory component effect, the effect of the anti-bacteria and anti-virus component of Fructus Monordicae extract and Guangxi beet berry extract is blue
The effect of indigo berry extract and the special light scar promoting healing component of apple extract, apple extract and the extraction of Guangxi beet fruit
The effect of the coefficient antiseptic ingredient of both things, and climbing fig addiction berry extract is in itself as a kind of natural stabilizer.
So that whole natural fruit extract component is directed to acne, what action effect the problem of small pox played brings out the best in each other.And then
The tyrosinase activity for tying compound Chinese medicine extract components suppresses synergistic effect, the activity and Desmocyte growth factor of anti-inflammatory
Son and Chinese medicine composite extract mutually cooperate with the effect for promoting cell Proliferation, and the special sustained anti-microbial sterilization of nano-graphene is made
With and do not produce the advantage of drug resistance, the present invention is that the efficiency of the advantage of various raw materials is fully perfectly combined,
More efficiently give play to overall lasting antimicrobial antiphlogistic anti-acne, light scar and promote cell Proliferation to cause the regenerated work(of skin
Effect.
, the present invention there is the composition of acne-removing and its preparation method of freeze-dried powder because biological transdermal enhancer comes
Plant fruit extract is come from, there is good biocompatibility, and skin will not be caused to damage, there is security.
Embodiment
The invention discloses the preparation method of a kind of composition with acne-removing and its freeze-dried powder, with reference to specific
Embodiment, the present invention will be further described：
Embodiment 1：
Composition with acne-removing, being calculated according to weight fraction includes following component：
10 parts of Chinese medical extract, 3 parts of climbing fig syconium extract, 3 parts of Fructus Monordicae extract, 4 parts of indigo berry extract, Guangxi sweet tea
2 parts of tea fruit extract, 6 parts of mango extract, 6 parts of longan extract, 10 parts of apple extract, 0.5 part of nano-graphene, into fibre
Tie up 0.01 part of Porcine HGF, dextran 1 part, 0.05 part of polyglutamic acid, 2 parts of mannitol, 65 parts of deionized water；Chinese medicine carries
Take thing is according to weight fraction meter, its component：5 parts of licorice, 5 parts of Salvia root P.E.
Embodiment 2：
Composition with acne-removing, being calculated according to weight fraction includes following component：
13 parts of Chinese medical extract, 4 parts of climbing fig syconium extract, 4 parts of Fructus Monordicae extract, 5 parts of indigo berry extract, Guangxi sweet tea
3 parts of tea fruit extract, 7 parts of mango extract, 7 parts of longan extract, 11 parts of apple extract, 0.5 part of nano-graphene, into fibre
Tie up 0.01 part of Porcine HGF, 2 parts of dextran, 0.08 part of polyglutamic acid, 3 parts of mannitol, 70 parts of deionized water；Chinese medicine carries
Take thing is according to weight fraction meter, its component：5 parts of licorice, 5 parts of Salvia root P.E.
Embodiment 3：
Composition with acne-removing, being calculated according to weight fraction includes following component：
15 parts of Chinese medical extract, 5 parts of climbing fig syconium extract, 5 parts of Fructus Monordicae extract, 6 parts of indigo berry extract, Guangxi sweet tea
4 parts of tea fruit extract, 8 parts of mango extract, 8 parts of longan extract, 12 parts of apple extract, 0.5 part of nano-graphene, into fibre
Tie up 0.01 part of Porcine HGF, 2 parts of dextran, 0.1 part of polyglutamic acid, 4 parts of mannitol, 85 parts of deionized water；Chinese medicine carries
Take thing is according to weight fraction meter, its component：5 parts of licorice, 5 parts of Salvia root P.E.
Raw material extracting method in each embodiment is as follows：
The preparation method of longan extract is using pectase and the double enzymes of cellulase while zymohydrolysis extracting method, and specific preparation method is such as
Under：Fresh longan is after 80 DEG C of heated-air dryings, peeled and cored, obtains longan fruit jerky, and 4 DEG C of low temperature of sealing saves backup；Weigh
Longan fruit jerky, adds deionized water immersion 12h, material-water ratio 1:3, smashed to pieces with high-speed tissue mashing machine；Stamping is taken to add
Deionized water, material-water ratio at this time is 1:12, digested at the same time using two kinds of enzymes of pectase and cellulase, according to mass percent
Calculate, pectin enzyme dosage 0.6%, cellulase dosage 0.05%, it is 3.1 to adjust pH value, 52 DEG C of hydrolysis temperature, enzymolysis time
160min, after enzymolysis, filtrate is collected by filtration in the enzyme deactivation 30min under the conditions of 90 DEG C, 200 mesh, concentrates the filtrate to half flowing
Slurry, then by slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, up to longan extract.
The preparation method of Guangxi Folium hydrangeae strigosae berry extract is as follows：Weigh Guangxi Folium hydrangeae strigosae pericarp meat to be placed in mortar, add 85% first
It is transferred to completely after alcoholic solution grinding in tool plug container, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 50
Min, room temperature cooling, 10 min are centrifuged by extracting solution under 4500 rpm/min rotating speeds；Centrifugation gained supernatant liquor is concentrated into
After half flowing slurry, by slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and are obtained Guangxi Folium hydrangeae strigosae fruit and are carried
Take thing.
The preparation method of climbing fig syconium extract, Fructus Monordicae extract and apple extract comprises the following steps：Will
The pericarp and pulp of liquid nitrogen grinding into the various raw materials of powder are separately added into 90% ethanol solution, solid-to-liquid ratio 1:33, in water temperature 31
DEG C, under the conditions of ultrasonic power 200W, ultrasonic extraction 38min, obtains extracting solution；Extracting solution filtering is concentrated under reduced pressure, obtains slurry；Will
Slurry is with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and respectively obtain climbing fig syconium extract, Siraitia grosvenorii
Extract and apple extract.
The preparation method of indigo berry extract is as follows：Indigo fruit surface silt is washed away with circulating water, ozone generator is led to
Enter and clean indigo fruit in sterile water again, drain stoning afterwards, pulp is crushed and breaks into pulp, be afterwards 40% by pulp volume
Deionized water is added, while adds pectase 3.5%, stands 30 min after stirring and evenly mixing under the conditions of 35 DEG C；Will be upper after standing
Layer clear liquid adds 95% ethanol solution, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 15min, in 4000 rpm/
10 min are centrifuged under min rotating speeds；After centrifugation gained supernatant liquor is concentrated into half flowing slurry, by slurry with 1：10 volumes
It is agitated, shake up than being dissolved in deionized water, obtain indigo berry extract.
The preparation method of mango extract is specific as follows：Mango pulp and pericarp freeze-dried powder are weighed, adds 80% the third
Ketone, the above two solid-to-liquid ratio are 1:20, ultrasonic extraction 30 min, supersonic frequency 60kHz, power 30W, 7000rpm/min's
Under the conditions of centrifuge 10 min, take supernatant, be repeated twice aforesaid operations, merge supernatant；By the supernatant after merging in rotation
It is evaporated on evaporimeter, the product obtained after being evaporated is with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and obtain mango
Extract.
The preparation method of the freeze-dried powder of the composition with acne-removing in embodiment, it is characterised in that including following step
Suddenly：
Step 1：Polyglutamic acid and deionized water are proportionally put into homogenizer, homogeneous 10min, complete under the conditions of 78 DEG C
Fully dissolved obtains A, places A Temperature falls afterwards；
Step 2：Mannitol and dextran are proportionally added when the temperature of A is down to 50 DEG C or so, is uniformly mixed and obtains B；
Step 3：30 DEG C or so, which are down to, when the temperature of B is proportionally added into Chinese medical extract, climbing fig syconium extract, Siraitia grosvenorii
Extract, indigo berry extract, Guangxi Folium hydrangeae strigosae berry extract, mango extract, longan extract, apple extract, nanometer stone
Black alkene, fibroblast growth factor are uniformly mixing to obtain C, C then are freezed 20h at -25 DEG C, to discharging after version qualification；
Step 4：C that freezing processing is crossed is filling to be placed in vacuum freeze, in -50 DEG C, the bar of vacuum 7Pa
Vacuum freeze drying processing 35h is carried out under part and obtains the freeze-dried powder of the composition with acne-removing containing the present invention.
On a kind of evaluation of the preparation method with the composition of acne-removing and its freeze-dried powder of the present invention：
The application method of freeze-dried powder of the present invention：First solvent is extracted out, in ampoule bottle of the injection equipped with freeze-dried powder, bottle is shaken, makes
Freeze-dried powder is thoroughly mixed with solvent, is made into freeze-dried powder solution.One bottle of freeze-dried powder solution first use, once a day.
Human skin irritation is tested
Select male, women each 100 of the age at 18-28 Sui, after continuous use 10 days, observation skin whether red and swollen, oedema, 10
The test result fed back after it occurs for 200 study subjects without red and swollen, oedema phenomenon, shows the freeze-dried powder of the present invention to skin
Without any stimulation, the people that may adapt to various skins uses skin.
Go acne effect detection
Selecting the face of 300 18-28 one full year of life has acne patient continuously after 30 days on probation, be divided into three groups of every group of 100 people feedbacks go acne,
Go acne effect.
Wherein, it is effective oneself to think that three groups of the number that acne, small pox substantially mitigate is respectively 75 people, 80 people and 77 people；
It is respectively 25 people, 20 people and 23 people effectively oneself to think that acne, small pox have mitigated three groups of the number to make moderate progress；It is invalid to be
Oneself think that acne, small pox mitigate unobvious or do not see that three groups of clear number is 0 people.From the point of view of testing result, three groups
Significant effect rate, that is, obvious effective rate be respectively 75%, 80% and 77%, three groups of average obvious effective rate is 77.3%.Prove the tool of the present invention
There are the composition of acne-removing and its preparation method of freeze-dried powder that there is very excellent anti-acne effect.If adhere to for a long time at the same time
Using the present invention, can also effectively resist the extraneous and oxidative factors of itself, resist pigment deposition and pockmark and
The formation of acne scar.Test sample in the present invention is the sample prepared in the embodiment of the present invention 3.
The present invention has in the composition of acne-removing and its preparation method of freeze-dried powder and a variety of fruit extracts are
Compound action system, its fully utilize longan extract headed by, climbing fig addiction berry extract and mango extract be auxiliary
The effect of the anti-bacteria and anti-virus component of the effect of collaboration anti-inflammatory component, Fructus Monordicae extract and Guangxi beet berry extract, indigo
The effect of berry extract and the special light scar promoting healing component of apple extract, apple extract and Guangxi beet berry extract
The effect of the two coefficient antiseptic ingredient, and climbing fig addiction berry extract is in itself as a kind of natural stabilizer.Make
Whole natural fruit extract component is directed to acne, what action effect the problem of small pox played brings out the best in each other.And then tie
The tyrosinase activity of compound Chinese medicine extract components suppresses synergistic effect, the activity and fibroblast growth factor of anti-inflammatory
The effect for promoting cell Proliferation, the special sustained anti-microbial bactericidal effect of nano-graphene are mutually cooperateed with Chinese medicine composite extract
And the advantage of drug resistance is not produced, the present invention is that the efficiency of the advantage of various raw materials is fully perfectly combined, more
Add and efficiently given play to overall lasting antimicrobial antiphlogistic anti-acne, light scar and promoted cell Proliferation so that the effect of skin regenerates.
The present invention has the composition of acne-removing and its preparation method of freeze-dried powder, because biological transdermal enhancer derives from plant fruit
Real extract, has good biocompatibility, and skin will not be caused to damage, and has security.
Exemplary description is carried out to the present invention above in conjunction with specific embodiment, it is clear that realization of the invention and from upper
The limitation of mode is stated, if the various improvement of inventive concept and technical scheme of the present invention progress are employed, or not improved general
The design and technical solution of the present invention directly applies to other occasions, within the scope of the present invention.
Claims (1)
1. a kind of preparation method of longan extract, it uses pectase and the double enzymes of cellulase zymohydrolysis extracting method at the same time, specifically
Preparation process is as follows：Fresh longan is after 80 DEG C of heated-air dryings, peeled and cored, obtains longan fruit jerky, the 4 DEG C of preservations of sealing low temperature
It is spare；Longan fruit jerky is weighed, adds deionized water immersion 12h, material-water ratio 1:3, smashed to pieces with high-speed tissue mashing machine；Take and smash
Mince and add deionized water, material-water ratio at this time is 1:12, digested at the same time using two kinds of enzymes of pectase and cellulase, according to matter
Measure percentage to calculate, pectin enzyme dosage 0.6%, cellulase dosage 0.05%, it is 3.1 to adjust pH value, 52 DEG C of hydrolysis temperature, enzyme
Time 160min is solved, after enzymolysis, the enzyme deactivation 30min under the conditions of 90 DEG C, 200 mesh are collected by filtration filtrate, concentrate the filtrate to
Half flowing slurry, then by slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and are extracted up to longan
Thing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711459815.6A CN107982159A (en) | 2017-11-30 | 2017-11-30 | A kind of preparation method of longan extract |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711459815.6A CN107982159A (en) | 2017-11-30 | 2017-11-30 | A kind of preparation method of longan extract |
| CN201711240432.XA CN107822979B (en) | 2017-11-30 | 2017-11-30 | Preparation method of freeze-dried powder of composition with acne removing effect |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711240432.XA Division CN107822979B (en) | 2017-11-30 | 2017-11-30 | Preparation method of freeze-dried powder of composition with acne removing effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107982159A true CN107982159A (en) | 2018-05-04 |
Family
ID=61646883
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711459815.6A Pending CN107982159A (en) | 2017-11-30 | 2017-11-30 | A kind of preparation method of longan extract |
| CN201711240432.XA Active CN107822979B (en) | 2017-11-30 | 2017-11-30 | Preparation method of freeze-dried powder of composition with acne removing effect |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711240432.XA Active CN107822979B (en) | 2017-11-30 | 2017-11-30 | Preparation method of freeze-dried powder of composition with acne removing effect |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN107982159A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110916127A (en) * | 2019-12-19 | 2020-03-27 | 广东石油化工学院 | Method for extracting soluble longan solid by enzymolysis |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101433620A (en) * | 2008-12-10 | 2009-05-20 | 广东省农业科学院农业生物技术研究所 | Longan water-soluble active substance as well as extraction method and use thereof |
| CN104431856A (en) * | 2014-12-25 | 2015-03-25 | 广东石油化工学院 | Preparation method of instant longan powder |
| CN105192707A (en) * | 2015-11-13 | 2015-12-30 | 廖广有 | Preparation method of longan fermentation beverage |
| CN106616179A (en) * | 2016-12-14 | 2017-05-10 | 广西壮族自治区农业科学院农产品加工研究所 | Preparation method of natural longan instant powder |
| CN107080778A (en) * | 2017-04-02 | 2017-08-22 | 方家铺子（福建）现代农业发展有限公司 | A kind of multiplex-enzyme extraction technique of longan pulp solid carbon dioxide insoluble active thing and application |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4199743B2 (en) * | 2005-03-03 | 2008-12-17 | 株式会社ディーエイチシー | Acne skin cosmetics |
| JP6253220B2 (en) * | 2012-03-30 | 2017-12-27 | 株式会社 資生堂 | APJ activator |
| KR20130134580A (en) * | 2012-05-31 | 2013-12-10 | 정은아 | Cosmetic compositions and layer comprising ultra-thin carbon |
| CN103961283B (en) * | 2014-04-04 | 2016-09-07 | 广州舒泰生物技术有限公司 | A kind of anti-acne repairs lyophilized formulations and preparation and application thereof |
| CN105380848A (en) * | 2015-11-25 | 2016-03-09 | 陕西艾美雅生物科技有限公司 | Composition, preparation method thereof, cosmetic containing composition and use method thereof |
| CN105748343B (en) * | 2016-02-25 | 2018-06-15 | 广州市科玮生物技术有限公司 | A kind of natural plant extracts composition and its application in cosmetics |
| KR101764533B1 (en) * | 2016-03-21 | 2017-08-14 | 약초생활건강 영농조합법인 | Composition of toothpaste containing extract of euphorbia supina |
| CN105997572B (en) * | 2016-05-19 | 2021-02-02 | 广州靓美莲美容科技有限公司 | Facial cleanser containing nano graphene and preparation method thereof |
| CN106619150B (en) * | 2017-02-20 | 2019-05-31 | 西安艾尔菲生物科技有限公司 | The natural sun-prevention moisturizing lipidosome freeze-dried powder of γ-PGA modification and its preparation and application |
-
2017
- 2017-11-30 CN CN201711459815.6A patent/CN107982159A/en active Pending
- 2017-11-30 CN CN201711240432.XA patent/CN107822979B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101433620A (en) * | 2008-12-10 | 2009-05-20 | 广东省农业科学院农业生物技术研究所 | Longan water-soluble active substance as well as extraction method and use thereof |
| CN104431856A (en) * | 2014-12-25 | 2015-03-25 | 广东石油化工学院 | Preparation method of instant longan powder |
| CN105192707A (en) * | 2015-11-13 | 2015-12-30 | 廖广有 | Preparation method of longan fermentation beverage |
| CN106616179A (en) * | 2016-12-14 | 2017-05-10 | 广西壮族自治区农业科学院农产品加工研究所 | Preparation method of natural longan instant powder |
| CN107080778A (en) * | 2017-04-02 | 2017-08-22 | 方家铺子（福建）现代农业发展有限公司 | A kind of multiplex-enzyme extraction technique of longan pulp solid carbon dioxide insoluble active thing and application |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110916127A (en) * | 2019-12-19 | 2020-03-27 | 广东石油化工学院 | Method for extracting soluble longan solid by enzymolysis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107822979B (en) | 2020-11-10 |
| CN107822979A (en) | 2018-03-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105769652B (en) | A kind of apple facial mask based on Chinese medicine preparation | |
| KR101805004B1 (en) | Fermentation method using medicinal leaf and skin external composition containing fermented extract by the method | |
| CN107937176A (en) | A kind of high-efficiency antioxidant anti-acne handmade soap | |
| KR102038650B1 (en) | Composite of Natural soap for skin cure and Method of manufacturing thereof | |
| CN102293733A (en) | Overall whitening and speckle removal skin care product | |
| CN104434618B (en) | Have whitening, nti-freckle concurrently and print nine grass green frosts of effect and preparation method thereof | |
| KR101952695B1 (en) | Composition having anti-wrinkle effects using the natural plant extract and cosmetic composition comprising the same | |
| CN101278994A (en) | Prinsepia utilis Royle oral nursing soft capsules | |
| KR102288724B1 (en) | Multi functional shampoo for pet comprising functional complex composition for improving function of anti-bacterial, sterilization, anti-inflammation and skin soothing, and enhancing skin immune and manufacturing method thereof | |
| CN105055250A (en) | Cosmetic containing phycocyanin and preparation method | |
| KR20160087113A (en) | Cosmetics containing flowers | |
| KR101903987B1 (en) | Functional cosmetic compositions for preventing skin aging using the natural fermented extracts and the cosmetics using the same | |
| CN104644528B (en) | A kind of preparation method and application of edible moisture-keeping nutrient ointment | |
| KR100873033B1 (en) | Cosmetic composition for massage pack | |
| KR102136090B1 (en) | The skin cosmetic composition for anti-oxidation and anti-inflammation of skin comprising natural complex extracts | |
| Singh et al. | The portent plant with a purpose: Aloe vera | |
| JP2011246417A (en) | Skin beautifying soap | |
| CN107805559A (en) | A kind of preparation method of high-efficiency antioxidant anti-acne handmade soap | |
| KR102051417B1 (en) | The cosmetic composition for the prevention and improvement of striae distensae | |
| CN107982159A (en) | A kind of preparation method of longan extract | |
| CN107875059A (en) | A kind of composition with acne-removing | |
| KR20130075207A (en) | Natural composition for preventing loss of hair and recovering of silverhair, and its manufacturing method | |
| CN107823114A (en) | A kind of anti-acne skin care item containing sealwort stem cell extract | |
| KR20070038487A (en) | Extracted admixtures for cerebral thrombosis and coronary thrombosis and for prophylax of glycosuria | |
| KR20120025197A (en) | Food composition for improving circulation of blood and manufacturing method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180504 |
|
| WD01 | Invention patent application deemed withdrawn after publication |