CN107875059A - A kind of composition with acne-removing - Google Patents
A kind of composition with acne-removing Download PDFInfo
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- CN107875059A CN107875059A CN201711243357.2A CN201711243357A CN107875059A CN 107875059 A CN107875059 A CN 107875059A CN 201711243357 A CN201711243357 A CN 201711243357A CN 107875059 A CN107875059 A CN 107875059A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
Abstract
The present invention relates to a kind of composition with acne-removing, it is characterised in that being calculated according to weight fraction includes following component：10 15 parts of Chinese medical extract, 35 parts of climbing fig syconium extract, 35 parts of Fructus Monordicae extract, 46 parts of indigo berry extract, 24 parts of Guangxi Folium hydrangeae strigosae berry extract, 68 parts of mango extract, 68 parts of longan extract, 10 12 parts of apple extract, 0.5 part of nano-graphene, 0.01 part of fibroblast growth factor, 2 parts of dextran 1,0.05 0.1 parts of polyglutamic acid, 24 parts of mannitol, 65 85 parts of deionized water.The present invention combines nano-graphene first, the active component in fibroblast growth factor and hjolomorphism natural fruit extract, prepares without preservative, non-stimulated, continues antibacterial efficient anti-inflammatory, anti-acne, prevents pockmark from being formed.Because biological transdermal enhancer derives from full fruit extract, there is good biocompatibility, and skin will not be caused to damage, there is security.
Description
Technical field
The invention belongs to everyday skincare preparing technical field, more particularly to a kind of composition with acne-removing.
Background technology
Whelk also known as acne, the generation of acne mainly blocks with hypersteatosis, pilosebaceous duct, bacterium sense
Dye and the factor such as inflammatory reaction are closely related.Adolesce the rapid rise of level of the particularly emerald green ketone of androgen in descendant's body,
Sebaceous glands is promoted to develop and produce a large amount of sebums.The dyskeratosis of pilosebaceous duct causes catheter blockage, sebum row simultaneously
Go out obstacle, it is micro mist thorn to form horn plug.Multiple-microorganism especially propionibacterium acnes amount reproduction, acne propionic acid in hair follicle
Lipase caused by bacillus decomposes sebum generation free fatty, while chemotactic inflammatory cell and medium, finally induces and aggravates inflammation
Disease is reacted.
With the lifting of people's consumption consciousness, consumer increasingly focuses on product when from cleaning product and skin care item
Security, the security of product is much than therapeutic and esthetics itself is important more.Natural plants and the extraction of animal
Thing sensitization rate itself is very low, and security is very high, using this kind of active component extract prepare the product of production also increasingly by
The attention of consumer and like.
Nano-graphene can kill the various bacteria of Pseudomonas aeruginosa, Escherichia coli etc. 10, because nano-graphene sheet
Body is the carbon atom to string, and just as one layer very thin very closely knit cloth, the mode that they tackle bacterium has three kinds：The first is
Directly cut, because graphene is nano level, and bacterium is micron order, and the former is smaller than the latter 1000 times, and graphene is just as one
Very sharp knife, directly bacterium is cut to death；Second is bacterium hungry to death, and nano level graphene can be as cloth by bacterium
Closely wrap up, bacterium is absorbed less than nutrition, die of starvation；The third is slowly to wither away, because graphene is too small, carefully
Bacterium can gulp down graphene inner enter " tripe ", can suffer from diarrhea uncomfortable just as people has eaten foreign matter, cause bacterium slowly to be withered away, exactly because
This physical sterilization method of graphene, allows bacterium not produce drug resistance, there is good acne-removing inflammation-diminishing effect to skin.
At present, many product for resolving poxes use the compositions such as hormone, antibiotic, vitamin A acid, and excitant is big, easily cause skin pair
The drug resistance of bacterium, security are constantly under suspicion.And such product does not have generally antibacterial and dispel long lasting for property
The ability that the effect of acne, no acne print and color spot are dispelled.
The content of the invention
For overcome the deficiencies in the prior art, it is an object of the present invention to provide a kind of composition and its jelly with acne-removing
The preparation method of dry powder, the product that effectively can solve to produce at present carry for the fruit active material of performance drug effect
Take it is inefficient, containing preservative, hormone injury skin, make skin produce drug resistance, and oxidation resistance is weak can not be effective
Prevent the problem of formation of pockmark and acne scar.
The present invention is achieved by the following technical solution：
A kind of composition with acne-removing, it is characterised in that being calculated according to weight fraction includes following component：Traditional Chinese medicine extraction
Thing 10-15 parts, climbing fig syconium extract 3-5 parts, Fructus Monordicae extract 3-5 parts, indigo berry extract 4-6 parts, Guangxi Folium hydrangeae strigosae
Berry extract 2-4 parts, mango extract 6-8 parts, longan extract 6-8 parts, apple extract 10-12 parts, nano-graphene 0.5
Part, 0.01 part of fibroblast growth factor, -2 parts of dextran 1, polyglutamic acid 0.05-0.1 parts, mannitol 2-4 parts, go from
Sub- water 65-85 parts；Described Chinese medical extract is according to weight fraction meter, its composition：5 parts of licorice, red sage root extraction
5 parts of thing；
The preparation method of described longan extract is specific to prepare using pectase and the double enzymes of cellulase while zymohydrolysis extracting method
Method is as follows：Fresh longan is after 80 DEG C of heated-air dryings, and peeling stoning obtains longan fruit jerky, and sealing 4 DEG C of preservations of low temperature are standby
With；Longan fruit jerky is weighed, adds deionized water immersion 12h, material-water ratio 1:3, smashed to pieces with high-speed tissue mashing machine；Take and smash to pieces
Thing adds deionized water, and material-water ratio now is 1:12, digested simultaneously using two kinds of enzymes of pectase and cellulase, according to quality
Percentage calculates, pectin enzyme dosage 0.6%, cellulase dosage 0.05%, and regulation pH value is 3.1,52 DEG C of hydrolysis temperature, enzymolysis
Time 160min, after enzymolysis terminates, filtrate is collected by filtration in the enzyme deactivation 30min under the conditions of 90 DEG C, 200 mesh, concentrates the filtrate to half
Slurry is flowed, then by slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and produce longan extract.
Further, the preparation method of described Guangxi Folium hydrangeae strigosae berry extract is as follows：Weigh Guangxi Folium hydrangeae strigosae pericarp meat and be placed in and grind
In alms bowl, it is transferred to completely in tool plug container after adding the grinding of 85% methanol solution, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W,
The min of ultrasonic extraction 50, room temperature cooling, 10 min are centrifuged by extract solution under 4500 rpm/min rotating speeds；Will centrifugation gained upper strata
After clear liquid is concentrated into half flowing slurry, by slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and are obtained extensively
Western Sweet tea berry extract.
Further, the preparation method of described climbing fig syconium extract, Fructus Monordicae extract and apple extract is wrapped
Include following steps：Liquid nitrogen grinding is separately added into 90% ethanol solution, solid-to-liquid ratio 1 into the pericarp and pulp of the various raw materials of powder:
33, under the conditions of 31 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 38min, obtain extract solution；Extract solution filtering is concentrated under reduced pressure,
Obtain slurry；By slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and are respectively obtained climbing fig syconium and are carried
Take thing, Fructus Monordicae extract and apple extract.
Further, the preparation method of described indigo berry extract is as follows：Indigo fruit surface silt is washed away with circulating water, will
Ozone generator is passed through in sterilized water cleans indigo fruit again, drains stoning afterwards, and pulp is crushed and breaks into pulp, afterwards by fruit
Volume of slurry is 40% addition deionized water, while adds pectase 3.5%, stands 30 min after stirring and evenly mixing under the conditions of 35 DEG C；
Supernatant liquor after standing is added into 95% ethanol solution, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction
15min, 10 min are centrifuged under 4000 rpm/min rotating speeds；After centrifugation gained supernatant liquor is concentrated into half flowing slurry,
By slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and obtain indigo berry extract.
Further, the preparation method of the mango extract is specific as follows：Weigh mango pulp and pericarp freeze dried powder
End, add 80% acetone, the above two solid-to-liquid ratio is 1:20, ultrasonic extraction 30 min, supersonic frequency 60kHz, power 30W,
10 min are centrifuged under conditions of 7000rpm/min, take supernatant, are repeated twice aforesaid operations, merge supernatant；After merging
Supernatant on Rotary Evaporators in being evaporated, and the product obtained after being evaporated is with 1：10 volume ratios are dissolved in deionized water, agitated,
Shake up, obtain mango extract.
A kind of preparation method of the freeze-dried powder of the composition with acne-removing, it is characterised in that comprise the following steps：
Step 1：Polyglutamic acid and deionized water are proportionally put into homogenizer, homogeneous 10min, complete under the conditions of 78 DEG C
Fully dissolved obtains A, places A Temperature falls afterwards；
Step 2：Mannitol and dextran are proportionally added when A temperature is down to 50 DEG C or so, it is well mixed to obtain B；
Step 3：30 DEG C or so, which are down to, when B temperature is proportionally added into Chinese medical extract, climbing fig syconium extract, Momordica grosvenori
Extract, indigo berry extract, Guangxi Folium hydrangeae strigosae berry extract, mango extract, longan extract, apple extract, nanometer stone
Black alkene, fibroblast growth factor are uniformly mixing to obtain C, and C is then freezed into 20h at -25 DEG C, discharged after qualified to version；
Step 4：It is placed in after C that freezing processing is crossed is filling in vacuum freeze, in -50 DEG C, vacuum 7Pa bar
Vacuum freeze drying processing 35h is carried out under part and obtains the freeze-dried powder of the composition with acne-removing containing the present invention.
Climbing fig is a kind of to have edible, medicinal and the ecological value evergreen liana concurrently.Climbing fig syconium is nutritious, achene and
The positions such as perianth are containing abundant nutritional ingredient.Content of fatty acid is very high in achene, up to 30.13%, predominantly unsaturated fat
Sour such as a- leukotrienes, linoleic acid;In addition, also containing abundant crude fibre (33.4%), protein (15.7%) and pectin
(15.15%) etc.;Amino acid analysis is shown, 17 kinds of amino acid, wherein content of glutamic acid highest, and human body are contained in climbing fig achene
Required 8 kinds of amino acid is various, and various mineral elements and vitamin content are also compared with horn of plenty.Modern study shows climbing fig syconium
Containing multiple compounds such as flavonoids, triterpenes, cumarin, glycosides, there is fabulous antioxidation activity, antibacterial activity, dispel
Wind dehumidifying, promoting blood circulation and removing obstruction in channels, subdhing swelling and detoxicating, the effect of anti-inflammatory, it is often more important that contain former delphinidin, the composition in climbing fig syconium
And a kind of natural stabilizer, the stabilizer in material system without additionally addition industrial goods, it is possible to while utilize Pi
The natural anti-inflammatory, antibacterial antioxidant material of litchi syconium utilizes it as the effect of natural stabiliser again.
Momordica grosvenori is the fruit of Dicotyledoneae Curcurbitaceae Genus Siraitia Merr, vegetable formal name " Semen Momordicae ".Arhat
Berry extract and isolated composition from Momordica grosvenori have clearing heat and detoxicating, antibechic clearing lung-heat, antibacterial anti-inflammatory, strengthen immune etc. make
With.Main active component be mogroside its be cucurbitane element triterpene sweet tea glycoside compound.Momordica grosvenori polysaccharide and mogroside
It is antiviral with antibacterial, radiation resistance.Also contain glycosides displayed and protein amino acids in Momordica grosvenori, contain 17 kinds of amino
Sour composition and 16 kinds of inorganic microelements, and VC contents it is more taller than Kiwi berry go out it is a lot, be a kind of nutritious crude drug
Fruit.
Indigo fruit category Caprifoliaceae, it is a kind of wild acinus class plant, seed is minimum, and crushing juice rate is high, contains abundant ammonia
Base acid, vitamin and bioactive substance, there is a superior antioxidation activity, and healthy nutritive value is high.Anthocyanin and flavones
Class compound has some beneficial physiological functions and pharmacological action, wherein pattern as the functional component in indigo fruits
Glycosides, which has, eliminates free radical, anti-aging, anti-oxidant, and anti-inflammatory and the function of improving immunity, flavone compound can promote human body
Interior blood circulation, amino acid, vitamin and anthocyanin and Flavonoid substances collective effect effectively can hinder in anti-inflammatory, promotion
Mouth healing, prevent scar from generating.Amino acid, vitamin and anthocyanin in indigo fruit can equally utilize other plant of the present invention
With effective flavones ingredient anti-inflammatory in fruit extract, it is anti-oxidant, promote wound healing, prevent scar generation play collaboration increase
The effect of effect.
Guangxi Folium hydrangeae strigosae is a new varieties for rose family rubus plant, is the distinctive plant in Guangxi.Sweet tea fruit its
Nutritious and complete, fruit soft and succulency, color and luster is pleasant, because of sweet tea in fact fragrance it is nutritious be processed into jam, fruit juice,
The products such as fruit wine.Fruit is medicinal, energy improving eyesight, kidney tonifying, qi-regulating of calming the nerves.Recent studies indicate that Sweet tea berry extract contain it is abundant
Terpenoid and volatile oil component, wherein main component is Quercetin and kaempferol, and both compositions all have good
Antibacterial, the effect of anti-inflammatory, there is good therapeutic effect for acne, small pox skin, while Sweet tea fruit extract is also a kind of
Natural preservative, without especially add preservative in raw material of the invention.
Mango is a kind of aiphyllium of original India, leaf keratin, alternate；It is warm-natured, small, yellow or pale red are spent, into top
Raw panicle.Mango Fruit contains sugar, protein, crude fibre, the precursor carrotene of the vitamin A contained by mango into
Dtex is not high, is rare in all fruit.Secondly Vitamin C content is not also low.Mineral matter, protein, fat, carbohydrate etc.,
And its main nutrient composition.Mango is one of famous tropical fruit (tree), because its pulp is fine and smooth, unique flavor, is loved by people,
So the reputation for being known as " tropical fruit king " claims.Most unique and most important composition in Mango Fruit extract is mangiferin, mango
Glycosides is polyphenol compound important in mango, belong to xanthone compound, mangiferin have efficient anti-inflammatory, immunological regulation with
And oxidation resistant effect, for skin inflammation have it is good and it is stable the effect of.
Longan is the famous subtropical fruit in China, and fruit popular name longan, it is " fruit Zisco product " to be praised highly by people.Longan is sought
One of very high and important medicinal material of foster value.There is abundant phospholipid fraction in arillus longan：Total phospholipids (mg/g) 3.95 ±
0.12, lysophosphatide phthalein choline 13.8, phospholipid acid choline 49. 5, phosphatide phthalein inositol 2.4, phosphatide phthalein serine 3.8, phosphatide phthalein
Monoethanolamine 3.8, phosphatidic acid 2.8, phosphatide phthalein glycerine 19.7, mentioned component is to skin anti-aging, increase body's immunity etc.
Aspect plays the role of stronger.Meanwhile the composition in longan pulp also containing abundant polysaccharide, polyphenol alcohols and terpenoid,
Most important of which composition is panaxoside, and the composition has the function that efficient anti-inflammatory, removing toxic substances and promotes cell growth.Can be with
Acted synergistically with other antimicrobial components in the present invention so that the antimicrobial antiphlogistic effect of product of the present invention greatly promotes.
Apple is one of ten big fruit of the world, and apple has very high health value, and apple aldehydes matter is to influence apple
A kind of important substance of health-care effect.Aldehydes matter is one of naturally occurring important secondary metabolites, is important day
Right antioxidant source.Apple is rich in sugar, protein, organic acid, vitamin and a variety of phenols components, wherein anthocyanin,
Phenolic acid and flavonoid substances are phenols components main in apple.Investigated according to nutritionists such as Holland, the U.S., apple is to be located at
The third-largest aldehydes matter dietary source after tea and onion.Many pharmacological researches show the aldehydes matter in apple, have more
Kind bioactivity, can remove oxygen radical excessive in vivo, there is very strong antioxidant effect.Apple extract can effectively drop
Low capillary vasopermeability, the microcirculation for improving skin surface, wound healing and scar desalination.Apple extract is in itself
A kind of and preservative.
Radix glycyrrhizae is known as the title of whitening queen, suppresses the activity of tyrosinase while its extract uvioresistant, moreover it is possible to change
Kind pachylosis, the problems such as water shortage inflammation.Its whitening function active ingredient is flavone compound such as liquiritin, glycyrrhizin,
Enoxolone, glycyrrhizin and some polysaccharose substances.Result of study is found, tyrosinase activity is pressed down when radix glycyrrhizae is used alone
Rate processed is very low, and compound increases 5-6 times to inhibitory activity against tyrosinase.
Red sage root chemical composition mainly has fat-soluble diterpene-kind compound such as tanshinone, water-soluble phenolic acids material for example red
Ginseng element, danshinolic acid and some polysaccharose substances.It removes free radical antioxygen when licorice and Salvia root P.E are used alone
Change ability is weaker, and photostability is very poor, but licorice and Salvia root P.E it is compound have more preferable photostability and
The antioxygenic property more increased into multiple.Composite extract can produce to people's dermal fibroblasts and people's epidermal keratinocyte propagation
Raw material impact, the extract of compound use can promote the propagation of people's dermal fibroblasts, enhance metabolism, and suppress people
Epidermal keratinocyte is bred, cutin-softening layer, promotes wound healing, will not produce stimulation to skin.Licorice and
The composite extract of Salvia root P.E can be well suppression butyric acid enzymatic activity.That is licorice and red sage root extraction
The compounding use of thing and nano-graphene can greatly improve suppresses synergistic effect and anti-inflammatory for tyrosinase activity
Activity.
Medicinal substances compatibility, which is used as medicine, in material in the present invention synergy to play anti-inflammation, the effect of anti-acne myogenic mutually
Fruit.Guangxi beet berry extract and apple extract can be cooperateed with to be collectively forming and more improve and effective anti-corrosion body again simultaneously
System.
Fibroblast growth factor (Fibroblast growth factors, FGFs) is a kind of multi-functional non-spy
A variety of mesoderms such as specific activities material, Human Umbilical Vein Endothelial Cells, fibroblast and the cell in the outer embryo source of nerve, which have, promotes DNA to close
Into with promote fissional effect.FGFs also plays double regulation control effect to fibroblastic collage synthesis:By to collagen
Continuous synthesis, secretion, reconstruction and renewal, and constantly improve the structure and intensity with repair tissue, while clostridiopetidase A can be stimulated
Expression, therefore can effectively suppress a large amount of synthesis because of collagen and excessive deposition and caused by pathologic scar, so as to improve
The quality of wound healing.
Nano-graphene can kill the various bacteria of Pseudomonas aeruginosa, Escherichia coli etc. 10, because nano-graphene sheet
Body is the carbon atom to string, and just as one layer very thin very closely knit cloth, the mode that they tackle bacterium has three kinds：The first is
Directly cut, because graphene is nano level, and bacterium is micron order, and the former is smaller than the latter 1000 times, and graphene is just as one
Very sharp knife, directly bacterium is cut to death；Second is bacterium hungry to death, and nano level graphene can be as cloth by bacterium
Closely wrap up, bacterium is absorbed less than nutrition, die of starvation；The third is slowly to wither away, because graphene is too small, carefully
Bacterium can gulp down graphene inner enter " tripe ", can suffer from diarrhea uncomfortable just as people has eaten foreign matter, cause bacterium slowly to be withered away, exactly because
This physical sterilization method of graphene, allows bacterium not produce drug resistance, there is good acne-removing inflammation-diminishing effect to skin.
The fruit component that will targetedly act on, nano-graphene and growth factor are used in combination, solution that can be more efficient
The problem of acne of certainly good skin is brought, while greatly improve antibacterial anti-inflammatory, anti-oxidant, promotion healing and the reparation of product
Performance.
There is the present invention composition of acne-removing and its preparation method of freeze-dried powder to have the advantages that：
1st, there is the present invention composition of acne-removing and its preparation method of freeze-dried powder to combine nano-graphene first, into fibre
The active component in Porcine HGF and hjolomorphism natural fruit extract is tieed up, is prepared without preservative, stabilizer, it is stingless
Swash, continue antibacterial efficient anti-inflammatory, anti-acne, the freeze-dried powder for preventing pockmark and acne scar from being formed.The present invention is without any industrial goods preservative
Add, there is safe and non-toxic natural antiseptic agent, good water solubility, heat endurance is good, sphere of action is wide in composition.
2nd, there is the present invention extract most in the composition of acne-removing and its preparation method of freeze-dried powder to use
Ultrasonic extraction carries, and the technique extraction efficiency is high, high for the active component utilization rate in fruit medicine, does not waste money
Source.The present invention using ultrasonic extraction prepares extract, utilizes judder caused by ultrasonic wave, higher acceleration, by force
The special effects such as strong cavitation effect, stirring, plant cell can be destroyed, solvent is penetrated into Materials Cell, promotes to wait to carry
Take the chemical composition in raw material to be dissolved in solvent, then required chemical composition is drawn by separating-purifying.Utilize ultrasonic wave extraction
30min will be higher by 9% than conventional decocting method extraction 3h recovery rate.
3rd, the present invention has the extraction of the composition of acne-removing and its a part of fruit in the preparation method of freeze-dried powder
Zymohydrolysis extracting method is used in the preparation method of thing, wherein the zymohydrolysis extracting method for having single kind also has the enzyme that a variety of enzymes are used in mixed way
Solve extraction method.Enzyme engineering technology is a biotechnology for being used for active ingredient of natural plant extraction in recent years.In life
In the extraction process of active substances, extraction conditions can be reduced using enzyme, plant tissue is decomposed in comparatively gentle condition, carries
High extracting efficiency.It has been effectively combined and has formd natural effective preservative system, without especially adding, pro-skin is non-stimulated,
Reduce cost.
4th, the present invention have acne-removing composition and its freeze-dried powder preparation method in and a variety of fruit extracts
For compound action system, its fully utilize longan extract headed by, climbing fig addiction berry extract and mango extract be auxiliary
Collaboration anti-inflammatory component effect, the effect of the anti-bacteria and anti-virus component of Fructus Monordicae extract and Guangxi beet berry extract is blue
The effect of indigo berry extract and the special light scar promoting healing component of apple extract, apple extract and the extraction of Guangxi beet fruit
The effect of the coefficient antiseptic ingredient of both things, and climbing fig addiction berry extract is in itself as a kind of natural stabilizer.
So that whole natural fruit extract component is directed to acne, what action effect the problem of small pox played brings out the best in each other.And then
The tyrosinase activity for tying compound Chinese medicine extract components suppresses synergistic effect, the activity and Desmocyte growth factor of anti-inflammatory
Son and Chinese medicine composite extract mutually cooperate with the effect for promoting cell propagation, and the special sustained anti-microbial sterilization of nano-graphene is made
With and do not produce the advantage of drug resistance, the present invention is that the efficiency of the advantage of various raw materials is fully perfectly combined,
More efficiently give play to overall lasting antimicrobial antiphlogistic anti-acne, light scar and promote cell to breed the work(for causing skin regeneration
Effect.
, the present invention have acne-removing composition and its freeze-dried powder preparation method because biological transdermal enhancer come
Plant fruit extract is come from, there is good biocompatibility, and skin will not be caused to damage, there is security.
Embodiment
The invention discloses the preparation method of a kind of composition with acne-removing and its freeze-dried powder, with reference to specific
Embodiment, the present invention will be further described：
Embodiment 1：
Composition with acne-removing, being calculated according to weight fraction includes following component：
10 parts of Chinese medical extract, 3 parts of climbing fig syconium extract, 3 parts of Fructus Monordicae extract, 4 parts of indigo berry extract, Guangxi sweet tea
2 parts of tea fruit extract, 6 parts of mango extract, 6 parts of longan extract, 10 parts of apple extract, 0.5 part of nano-graphene, into fibre
Tie up 0.01 part of Porcine HGF, dextran 1 part, 0.05 part of polyglutamic acid, 2 parts of mannitol, 65 parts of deionized water；Chinese medicine carries
Take thing is according to weight fraction meter, its composition：5 parts of licorice, 5 parts of Salvia root P.E.
Embodiment 2：
Composition with acne-removing, being calculated according to weight fraction includes following component：
13 parts of Chinese medical extract, 4 parts of climbing fig syconium extract, 4 parts of Fructus Monordicae extract, 5 parts of indigo berry extract, Guangxi sweet tea
3 parts of tea fruit extract, 7 parts of mango extract, 7 parts of longan extract, 11 parts of apple extract, 0.5 part of nano-graphene, into fibre
Tie up 0.01 part of Porcine HGF, 2 parts of dextran, 0.08 part of polyglutamic acid, 3 parts of mannitol, 70 parts of deionized water；Chinese medicine carries
Take thing is according to weight fraction meter, its composition：5 parts of licorice, 5 parts of Salvia root P.E.
Embodiment 3：
Composition with acne-removing, being calculated according to weight fraction includes following component：
15 parts of Chinese medical extract, 5 parts of climbing fig syconium extract, 5 parts of Fructus Monordicae extract, 6 parts of indigo berry extract, Guangxi sweet tea
4 parts of tea fruit extract, 8 parts of mango extract, 8 parts of longan extract, 12 parts of apple extract, 0.5 part of nano-graphene, into fibre
Tie up 0.01 part of Porcine HGF, 2 parts of dextran, 0.1 part of polyglutamic acid, 4 parts of mannitol, 85 parts of deionized water；Chinese medicine carries
Take thing is according to weight fraction meter, its composition：5 parts of licorice, 5 parts of Salvia root P.E.
Raw material extracting method in each embodiment is as follows：
The preparation method of longan extract is using pectase and the double enzymes of cellulase while zymohydrolysis extracting method, and specific preparation method is such as
Under：Fresh longan is after 80 DEG C of heated-air dryings, peeling stoning, obtains longan fruit jerky, and 4 DEG C of low temperature of sealing saves backup；Weigh
Longan fruit jerky, add deionized water immersion 12h, material-water ratio 1:3, smashed to pieces with high-speed tissue mashing machine；Stamping is taken to add
Deionized water, material-water ratio now is 1:12, digested simultaneously using two kinds of enzymes of pectase and cellulase, according to mass percent
Calculate, pectin enzyme dosage 0.6%, cellulase dosage 0.05%, regulation pH value is 3.1,52 DEG C of hydrolysis temperature, enzymolysis time
160min, after enzymolysis terminates, filtrate is collected by filtration in the enzyme deactivation 30min under the conditions of 90 DEG C, 200 mesh, concentrates the filtrate to half flowing
Slurry, then by slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and produce longan extract.
The preparation method of Guangxi Folium hydrangeae strigosae berry extract is as follows：Weigh Guangxi Folium hydrangeae strigosae pericarp meat to be placed in mortar, add 85% first
It is transferred to completely after alcoholic solution grinding in tool plug container, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 50
Min, room temperature cooling, 10 min are centrifuged by extract solution under 4500 rpm/min rotating speeds；Centrifugation gained supernatant liquor is concentrated into
After half flowing slurry, by slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and are obtained Guangxi Folium hydrangeae strigosae fruit and are carried
Take thing.
The preparation method of climbing fig syconium extract, Fructus Monordicae extract and apple extract comprises the following steps：Will
Liquid nitrogen grinding is separately added into 90% ethanol solution, solid-to-liquid ratio 1 into the pericarp and pulp of the various raw materials of powder:33, in water temperature 31
DEG C, under the conditions of ultrasonic power 200W, ultrasonic extraction 38min, obtain extract solution；Extract solution filtering is concentrated under reduced pressure, obtains slurry；Will
Slurry is with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and respectively obtain climbing fig syconium extract, Momordica grosvenori
Extract and apple extract.
The preparation method of indigo berry extract is as follows：Indigo fruit surface silt is washed away with circulating water, ozone generator is led to
Enter and clean indigo fruit in sterilized water again, drain stoning afterwards, pulp is crushed and breaks into pulp, be afterwards 40% by pulp volume
Deionized water is added, while adds pectase 3.5%, stands 30 min after stirring and evenly mixing under the conditions of 35 DEG C；Will be upper after standing
Layer clear liquid adds 95% ethanol solution, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 15min, in 4000 rpm/
10 min are centrifuged under min rotating speeds；After centrifugation gained supernatant liquor is concentrated into half flowing slurry, by slurry with 1：10 volumes
It is agitated, shake up than being dissolved in deionized water, obtain indigo berry extract.
The preparation method of mango extract is specific as follows：Mango pulp and pericarp freeze-dried powder are weighed, adds 80% the third
Ketone, the above two solid-to-liquid ratio are 1:20, ultrasonic extraction 30 min, supersonic frequency 60kHz, power 30W, 7000rpm/min's
Under the conditions of centrifuge 10 min, take supernatant, be repeated twice aforesaid operations, merge supernatant；By the supernatant after merging in rotation
It is evaporated on evaporimeter, the product obtained after being evaporated is with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and obtain mango
Extract.
The preparation method of the freeze-dried powder of the composition with acne-removing in embodiment, it is characterised in that including following step
Suddenly：
Step 1：Polyglutamic acid and deionized water are proportionally put into homogenizer, homogeneous 10min, complete under the conditions of 78 DEG C
Fully dissolved obtains A, places A Temperature falls afterwards；
Step 2：Mannitol and dextran are proportionally added when A temperature is down to 50 DEG C or so, it is well mixed to obtain B；
Step 3：30 DEG C or so, which are down to, when B temperature is proportionally added into Chinese medical extract, climbing fig syconium extract, Momordica grosvenori
Extract, indigo berry extract, Guangxi Folium hydrangeae strigosae berry extract, mango extract, longan extract, apple extract, nanometer stone
Black alkene, fibroblast growth factor are uniformly mixing to obtain C, and C is then freezed into 20h at -25 DEG C, discharged after qualified to version；
Step 4：It is placed in after C that freezing processing is crossed is filling in vacuum freeze, in -50 DEG C, vacuum 7Pa bar
Vacuum freeze drying processing 35h is carried out under part and obtains the freeze-dried powder of the composition with acne-removing containing the present invention.
On a kind of evaluation of preparation method effect of composition and its freeze-dried powder with acne-removing of the present invention：
The application method of freeze-dried powder of the present invention：First solvent is extracted out, in ampoule bottle of the injection equipped with freeze-dried powder, bottle is shaken, makes
Freeze-dried powder is thoroughly mixed with solvent, is made into freeze-dried powder solution.One bottle of freeze-dried powder solution first use, once a day.
Human body skin excitant is tested
Select male, women each 100 of the age 18-28 year, after continuous use 10 days, observation skin whether red and swollen, oedema, 10
The test result fed back after it is that 200 study subjects occur without red and swollen, oedema phenomenon, shows the freeze-dried powder of the present invention to skin
Without any stimulation, the people that may adapt to various skins uses skin.
Go acne effect detection
Selecting the face of 300 18-28 one full year of life has acne patient continuously after 30 days on probation, be divided into three groups of every group of 100 people feedbacks go acne,
Go acne effect.
Wherein, it is effective oneself to think that three groups of the number that acne, small pox substantially mitigate is respectively 75 people, 80 people and 77 people；
It is respectively 25 people, 20 people and 23 people effectively oneself to think that acne, small pox have mitigated three groups of the number to make moderate progress；It is invalid to be
Oneself think that acne, small pox mitigate unobvious or do not see that three groups of clear number is 0 people.From the point of view of testing result, three groups
Significant effect rate be that obvious effective rate is respectively 75%, 80% and 77%, three groups of average obvious effective rate is 77.3%.Prove the tool of the present invention
There are the composition of acne-removing and its preparation method of freeze-dried powder that there is very excellent anti-acne effect.If adhere to for a long time simultaneously
Using the present invention, can also effectively resist the extraneous and oxidative factors of itself, resist pigment deposition and pockmark and
The formation of acne scar.Test sample in the present invention is the sample prepared in the embodiment of the present invention 3.
The present invention has in the composition of acne-removing and its preparation method of freeze-dried powder and a variety of fruit extracts are
Compound action system, its fully utilize longan extract headed by, climbing fig addiction berry extract and mango extract be auxiliary
The effect of the anti-bacteria and anti-virus component of the effect of collaboration anti-inflammatory component, Fructus Monordicae extract and Guangxi beet berry extract, indigo
The effect of berry extract and the special light scar promoting healing component of apple extract, apple extract and Guangxi beet berry extract
The effect of the two coefficient antiseptic ingredient, and climbing fig addiction berry extract is in itself as a kind of natural stabilizer.Make
Whole natural fruit extract component is directed to acne, what action effect the problem of small pox played brings out the best in each other.And then tie
The tyrosinase activity of compound Chinese medicine extract components suppresses synergistic effect, the activity and fibroblast growth factor of anti-inflammatory
The effect for promoting cell propagation, the special sustained anti-microbial bactericidal action of nano-graphene are mutually cooperateed with Chinese medicine composite extract
And the advantage of drug resistance is not produced, the present invention is that the efficiency of the advantage of various raw materials is fully perfectly combined, more
Add and efficiently given play to overall lasting antimicrobial antiphlogistic anti-acne, light scar and promoted cell to breed the effect of causing skin regeneration.
The present invention has the composition of acne-removing and its preparation method of freeze-dried powder, because biological transdermal enhancer derives from plant fruit
Real extract, there is good biocompatibility, and skin will not be caused to damage, there is security.
Exemplary description is carried out to the present invention above in conjunction with specific embodiment, it is clear that realization of the invention is not by upper
The limitation of mode is stated, if the various improvement of inventive concept and technical scheme of the present invention progress are employed, or not improved general
The design and technical scheme of the present invention directly applies to other occasions, within the scope of the present invention.
Claims (5)
1. a kind of composition with acne-removing, it is characterised in that being calculated according to weight fraction includes following component：Chinese medicine carries
Take thing 10-15 parts, climbing fig syconium extract 3-5 parts, Fructus Monordicae extract 3-5 parts, indigo berry extract 4-6 parts, Guangxi sweet tea
Tea fruit extract 2-4 parts, mango extract 6-8 parts, longan extract 6-8 parts, apple extract 10-12 parts, nano-graphene
0.5 part, 0.01 part of fibroblast growth factor, -2 parts of dextran 1, polyglutamic acid 0.05-0.1 parts, mannitol 2-4 parts,
Deionized water 65-85 parts；Described Chinese medical extract is according to weight fraction meter, its composition：5 parts of licorice, the red sage root
5 parts of extract；
The preparation method of described longan extract is specific to prepare using pectase and the double enzymes of cellulase while zymohydrolysis extracting method
Method is as follows：Fresh longan is after 80 DEG C of heated-air dryings, and peeling stoning obtains longan fruit jerky, and sealing 4 DEG C of preservations of low temperature are standby
With；Longan fruit jerky is weighed, adds deionized water immersion 12h, material-water ratio 1:3, smashed to pieces with high-speed tissue mashing machine；Take and smash to pieces
Thing adds deionized water, and material-water ratio now is 1:12, digested simultaneously using two kinds of enzymes of pectase and cellulase, according to quality
Percentage calculates, pectin enzyme dosage 0.6%, cellulase dosage 0.05%, and regulation pH value is 3.1,52 DEG C of hydrolysis temperature, enzymolysis
Time 160min, after enzymolysis terminates, filtrate is collected by filtration in the enzyme deactivation 30min under the conditions of 90 DEG C, 200 mesh, concentrates the filtrate to half
Slurry is flowed, then by slurry with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and produce longan extract.
2. the composition according to claim 1 with acne-removing, it is characterised in that：Described Guangxi Folium hydrangeae strigosae fruit extraction
The preparation method of thing is as follows：Weigh Guangxi Folium hydrangeae strigosae pericarp meat to be placed in mortar, be transferred to completely after adding the grinding of 85% methanol solution
In tool plug container, under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, the min of ultrasonic extraction 50, room temperature cooling, extract solution is existed
10 min are centrifuged under 4500 rpm/min rotating speeds；After centrifugation gained supernatant liquor is concentrated into half flowing slurry, by slurry
With 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and obtain Guangxi Folium hydrangeae strigosae berry extract.
3. the composition according to claim 1 or 2 with acne-removing, it is characterised in that：Described climbing fig syconium
The preparation method of extract, Fructus Monordicae extract and apple extract comprises the following steps：By liquid nitrogen grinding into the various of powder
The pericarp and pulp of raw material are separately added into 90% ethanol solution, solid-to-liquid ratio 1:33, in 31 DEG C of water temperature, ultrasonic power 200W conditions
Under, ultrasonic extraction 38min, obtain extract solution；Extract solution filtering is concentrated under reduced pressure, obtains slurry；By slurry with 1：10 volume ratios
It is dissolved in deionized water, it is agitated, shake up, respectively obtain climbing fig syconium extract, Fructus Monordicae extract and apple extract.
4. the composition according to claim 3 with acne-removing, it is characterised in that：Described indigo berry extract
Preparation method is as follows：Indigo fruit surface silt is washed away with circulating water, ozone generator is passed through in sterilized water and cleans indigo again
Fruit, stoning is drained afterwards, pulp is crushed and breaks into pulp, be afterwards 40% addition deionized water by pulp volume, while add fruit
Glue enzyme 3.5%, 30 min are stood after stirring and evenly mixing under the conditions of 35 DEG C；Supernatant liquor after standing is added into 95% ethanol solution,
Under the conditions of 40 DEG C of water temperature, ultrasonic power 200W, ultrasonic extraction 15min, 10 min are centrifuged under 4000 rpm/min rotating speeds；Will
After centrifugation gained supernatant liquor is concentrated into half flowing slurry, by slurry with 1：10 volume ratios are dissolved in deionized water, through stirring
Mix, shake up, obtain indigo berry extract.
5. the composition with acne-removing according to claim 1 or 4, it is characterised in that：The mango extract
Preparation method is specific as follows：Mango pulp and pericarp freeze-dried powder are weighed, adds 80% acetone, the above two solid-to-liquid ratio is 1:
20, the min of ultrasonic extraction 30, supersonic frequency 60kHz, power 30W, 10 min are centrifuged under conditions of 7000rpm/min, are taken
Clear liquid, aforesaid operations are repeated twice, merge supernatant；By the supernatant after merging in being evaporated on Rotary Evaporators, after being evaporated
Obtained product is with 1：10 volume ratios are dissolved in deionized water, agitated, shake up, and obtain mango extract.
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|---|---|---|---|---|
| CN110101650A (en) * | 2019-06-20 | 2019-08-09 | 李祥 | A kind of anti-inflammatory acne-eliminating cosmetic composition |
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