CN107965167A - Cell preparation laboratory design scheme - Google Patents

Cell preparation laboratory design scheme Download PDF

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Publication number
CN107965167A
CN107965167A CN201711387341.9A CN201711387341A CN107965167A CN 107965167 A CN107965167 A CN 107965167A CN 201711387341 A CN201711387341 A CN 201711387341A CN 107965167 A CN107965167 A CN 107965167A
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CN
China
Prior art keywords
room
preparation
adjacent
buffering
area
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Granted
Application number
CN201711387341.9A
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Chinese (zh)
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CN107965167B (en
Inventor
曹毓琳
刘俊江
时兆田
白志惠
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Distance Education Education Technology Center
Beijing Tangyihuikang Biomedical Technology Co Ltd
Original Assignee
Beijing Zhen Huikang Biological Technology Co ltd
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Priority to CN201711387341.9A priority Critical patent/CN107965167B/en
Publication of CN107965167A publication Critical patent/CN107965167A/en
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Publication of CN107965167B publication Critical patent/CN107965167B/en
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Classifications

    • EFIXED CONSTRUCTIONS
    • E04BUILDING
    • E04HBUILDINGS OR LIKE STRUCTURES FOR PARTICULAR PURPOSES; SWIMMING OR SPLASH BATHS OR POOLS; MASTS; FENCING; TENTS OR CANOPIES, IN GENERAL
    • E04H1/00Buildings or groups of buildings for dwelling or office purposes; General layout, e.g. modular co-ordination or staggered storeys
    • E04H1/12Small buildings or other erections for limited occupation, erected in the open air or arranged in buildings, e.g. kiosks, waiting shelters for bus stops or for filling stations, roofs for railway platforms, watchmen's huts or dressing cubicles

Abstract

The invention discloses a design scheme of a cell preparation laboratory, which comprises a preparation chamber, wherein a material flow chamber, a treatment chamber, a human flow chamber and a monitoring chamber are sequentially arranged around the preparation chamber; a first preparation area is arranged between the monitoring chamber and the preparation chamber; a second preparation area is arranged between the human flow chamber and the preparation chamber; one side of the interior of the preparation chamber, which is adjacent to the treatment chamber, is provided with an adjacent culture chamber and a culture medium preparation room, the culture chamber is adjacent to the logistics chamber, and the culture medium preparation room is adjacent to the second preparation area; the preparation room is inside to be equipped with between aseptic manipulation room and fourth buffering with the adjacent one side in first preparation district, and aseptic manipulation room is adjacent with commodity circulation room and cultivation room, and the fourth buffering is adjacent with aseptic manipulation room and second preparation district, is equipped with adjacent washing room and disinfection room between fourth buffering room and cultivation room and the culture medium preparation room, and the washing room is adjacent with aseptic manipulation room, and the disinfection room is adjacent with the second preparation district.

Description

A kind of cell prepares lab design scheme
Technical field
The invention belongs to architectural design field;Lab design scheme is prepared more particularly to a kind of cell.
Background technology
With the raising of China's science and technology, cell preparation techniques also improve therewith, and prepared by cell is used for extensive field;Such as medicine Thing researchs and develops, such as new medicament screen, prepared by vaccine, genetically engineered drug, cell engineering Drug development and research, monoclonal antibody Deng;Basic research, such as drug mechanism, gene function, disease genesis mechanism research;Bio-pharmaceuticals, such as production of vaccine:Such as Viral vaccine (hepatitis virus vaccine, AIDS vaccine etc.), polypeptide vaccine tumor vaccine) etc.;Genetically engineered drug produces:Such as EPO etc.;Antibody drug, gene therapy medicament production;Cell engineering medicine produces:Some bioactivity in biological cell are more Peptide, bioactive substance etc.;Utilize the activity of cell method external test bioactive substance;And predict its drug effect in vivo and Substitute the bioactivity that in vivo method detects its finished product;But cell prepares laboratory and needs very high requirement, cell prepares experiment Room, is made of, its main laboratory is also referred to as the environmental requirement of core space main laboratory, auxiliary room, isolating device:Clean rank, Rate of ventilation, the minimum differntial pressure of relative atmospheric, the minimum differntial pressure Pa that communicates room adjacent with outdoor direction, humiture, noise, Average illumination, the tightness of building enclosure, national standard (GB50346-2011) have clear and definite standard requirement;These rooms and every Rational layout is needed from device, work efficiency could be improved;The layout of the prior art is disorderly and unsystematic, and each function room is with isolating Relative position between device is arbitrarily laid out, and can not meet workflow and the environmental requirement of microcell experiment.
The content of the invention
In order to solve the problems in the existing technology, the present invention provides a kind of cell and prepares lab design scheme.
Concrete technical scheme of the present invention is as follows:
A kind of cell prepares lab design scheme, including preparation room, the surrounding of the preparation room be equipped with successively logistics room, Process chamber, people's flow chamber and monitoring room;The first area in preparation is equipped between the monitoring room and the preparation room;People's flow chamber and institute State and be equipped with the second area in preparation between preparation room;The side adjacent with the process chamber is equipped with adjacent culture inside the preparation room Between prepared by room and culture medium, the culturing room is adjacent with the logistics room, between the culture medium preparation with second area in preparation It is adjacent;The side adjacent with first area in preparation is equipped between sterile room and the 4th buffering inside the preparation room, described Sterile room is adjacent with the logistics room and culturing room, it is described 4th buffering between with the sterile room and the second area in preparation It is adjacent, between being prepared between the 4th buffering culturing room and culture medium between be equipped with adjacent washroom and disinfection room, it is described to wash Adjacent with the sterile room between washing, the disinfection room is adjacent with second area in preparation.
Optimization, the culturing room and the culture medium prepare between be equipped with double door leafs pass-through box;The sterile room Double door leafs pass-through box is equipped between the washroom.
Optimization, stream of people's chamber interior successively be equipped with towards first area in preparation first buffering between, changing rooms, purple Between outside line sterilization and the first air lock;Stream of people's chamber interior is also equipped with the second buffering towards second area in preparation successively Between, rinse between and the second air lock;Between second buffering between the described first buffering, phase between changing rooms and ultraviolet sterilization Neighbour, it is described second buffering between opposite side be equipped with dry house, between the flushing second buffer between and dry house it is adjacent, described second Air lock is adjacent with first air lock and the second area in preparation.
Optimization, the logistics chamber interior includes cellular identification adjacent between material conveying and between material conveying Between;Opposite side is connected with the cell storeroom that between the preparation and the first area in preparation is adjacent between the cellular identification;It is described Bottom is equipped with double door between material conveying;Between material conveying between the cellular identification between be equipped with two double door leafs side by side and pass Pass window;Side is equipped between the 3rd buffering between the cellular identification;It is equipped between 3rd buffering between the 3rd buffering that comes in and goes out Double door;Sliding door is equipped between the cellular identification between the cell storeroom;The cell storeroom and the nothing Double door leafs pass-through box is equipped between bacterium operating room.
Optimization, the monitoring room side adjacent with first area in preparation uses glass wall construction.
Optimization, the side adjacent with the process chamber is equipped between sterilizing in second area in preparation;The sterilization Connected between disinfection room and the process chamber by sliding door;The culture medium prepare between the sterilizing between be equipped with Double door leaf pass-through boxes.
Optimization, the preparation room is internally provided with the super-silent wind turbine that can make indoor generation negative pressure;The super-silent wind turbine Air outlet is equipped with air processor.
Optimization, between the flushing between the sterilizing between be equipped with double door leafs pass-through boxes.
Optimization, the preparation room is equipped with sealed glass door with the process chamber junction;The sealed glass door is close Sliding door one end of the process chamber disengaging.
Beneficial effects of the present invention are as follows:
The present invention has the stream of people, logistics, dirt stream clear compared with prior art, has a safety feature, floor space is small, thing Stream is reasonable, and production operation is more convenient, and design meets standard, specification, can meet the experiment of clinical, diagnosis, teaching and research, safety Reliably, energy-saving and emission-reduction, to biology laboratory engineering construction, have certain directive significance.
Brief description of the drawings
Fig. 1 prepares lab design solution layout figure for a kind of cell provided by the invention;
Fig. 2 prepares lab design Solution Embodiments figure for a kind of cell provided by the invention;
Fig. 3 prepares lab design scheme experiment flow figure for a kind of cell provided by the invention.
Embodiment
Below in conjunction with the attached drawing in the embodiment of the present invention, the technical solution in the embodiment of the present invention is carried out clear, complete Site preparation describes, it is clear that described embodiment is only part of the embodiment of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, those of ordinary skill in the art are obtained every other without making creative work Embodiment, belongs to the scope of protection of the invention.
Embodiment 1
Refering to Figure 1, the present invention, which provides a kind of cell, prepares lab design scheme, including preparation room 1, the system The surrounding of standby room 1 is equipped with logistics room 5, process chamber 2, people's flow chamber 4 and monitoring room 6 successively;The monitoring room 6 and the preparation room 1 Between be equipped with the first area in preparation 7;The second area in preparation 3 is equipped between people's flow chamber 4 and the preparation room 1;Refer to Fig. 2 institutes Show, the inside of the preparation room 1 and the adjacent side of the process chamber 2 are equipped with adjacent culturing room 12 and culture medium prepare between 14, The culturing room 12 is adjacent with the logistics room 5, and 14 is adjacent with second area in preparation 3 between prepared by the culture medium;The system The adjacent side in the standby inside of room 1 and first area in preparation 7 be equipped with sterile room 15 and the 4th buffer between 16, the sterile behaviour It is adjacent with the logistics room 5 and culturing room 12 to make room 15,16 is accurate with the sterile room 15 and second between the 4th buffering Preparation area 3 is adjacent, between the 4th buffering 16 and culturing room 12 and culture medium prepare between be equipped between 14 adjacent washroom 13 and Disinfection room 17, the washroom 13 is adjacent with the sterile room 15, the disinfection room 17 and 3 phase of the second area in preparation It is adjacent;The air pressure inside in house is centered on preparation room to the form design that both sides are incremental.
Double door leafs pass-through box is equipped between 14 between the culturing room 12 and culture medium preparation;The sterile room 15 with Double door leafs pass-through box is equipped between the washroom 13.
Experimenter enters the first area in preparation by people's flow chamber, enters the 4th buffering area from the first area in preparation, slow from the 4th Sterile room and washroom can be respectively enterd by rushing area;From culturing room can be entered between sterile working;It can enter disinfection from washroom Between;It can enter culture medium preparation room from disinfection room;Utensil in experiment in sterile room can be sent into by double door leaf pass-through boxes to be washed Washed between washing, disinfection room disinfection is put into after having washed;Laboratory technician can be from double door leaf pass-through boxes by the culture in culture medium preparation room Base is sent into culturing room.
Embodiment 2
Refer to shown in Fig. 2 and Fig. 3, as a kind of technical optimization scheme of the present invention, set successively inside people's flow chamber 4 Have towards 41, changing rooms 42 between the first buffering of first area in preparation 7,43 and first air lock 44 between ultraviolet sterilization;Institute State inside people's flow chamber 4 be also equipped with successively towards 45 between the second buffering of second area in preparation 3, rinse between 47 and second air lock 48;43 adjacent between 41, changing rooms 42 and ultraviolet sterilization between 45 and first buffering between second buffering, described second is slow 45 opposite sides are equipped with dry house 46 between punching, between the flushing 47 and second buffering between 45 and dry house 46 it is adjacent, second gas Lock chamber 48 is adjacent with 44 and second area in preparation 3 of the first air lock, and sliding door connection is equipped between connected.
Experimenter is equipped with 41 between the first buffering for leading to first area in preparation 7 successively inside people's flow chamber 4, then Into changing rooms 42, clothing is replaced inside changing rooms, puts on protective garment etc., is killed carrying out disinfection between ultraviolet sterilization 43 Bacterium, is entering the first area in preparation 7 by the first air lock 44, is finally entering preparation room 1 and work, sliding door is equipped between connected Connection;After having worked, out enter the second area in preparation 3 from preparation room 1, entering back into the second air lock 48, to carry out preliminary dust clear Remove;47 will be rinsed between flushing is entered, and the article rinsed is sent between sterilizing from double-deck title page pass-through box;Pass through again Dry house enters between the second buffering, out changes clothes into changing rooms between the second buffering, checks card after between the first buffering Go out.
As a kind of technical optimization scheme of the present invention, the inside of the logistics room 5 include between material conveying 51 and with it is described Between material conveying 52 between 51 adjacent cellular identifications;52 opposite sides are connected with 1 and between the preparation between the cellular identification Surely the adjacent cell storeroom 53 in preparation area 7;51 bottoms are equipped with double door between the material conveying;51 between the material conveying Two double door leafs pass-through boxes are equipped between 52 between the cellular identification side by side;52 sides are equipped with the 3rd buffering between the cellular identification Between 521;521 equipped between the 3rd buffering that comes in and goes out 521 double door between 3rd buffering;Between the cellular identification 52 with Sliding door is equipped between the cell storeroom 53;Double door leafs are equipped between the cell storeroom 53 and the sterile room 15 Pass-through box.
Logistics personnel from materials handling to material is conveyed material be sent to cell by double door leaf pass-through boxes in 51 reflect Fixed interior carry out cellular identification;Cell storeroom is sent into after cellular identification is complete and carries out classification storage;The material of cell storeroom The first area in preparation can be passed to by double door leaf pass-through boxes.
As a kind of technical optimization scheme of the present invention, the monitoring room 6 side adjacent with first area in preparation 7 is adopted With glass wall construction.
As a kind of technical optimization scheme of the present invention, in second area in preparation 3 side adjacent with the process chamber 2 Equipped between sterilizing 32;Connected between the sterilizing between 32 and the process chamber 2 by sliding door;The culture medium system Between standby 32 between 14 and the sterilizing between be equipped with double door leafs pass-through box;Cleanup crew can be by the article between sterilizing 32 Handled between feeding processing;Residue in culture medium preparation room is being sent into after being sent into by double door leaf pass-through boxes between sterilizing Process chamber is handled.
As a kind of technical optimization scheme of the present invention, the preparation room 1, which is internally provided with, can make the super of indoor generation negative pressure Mute wind turbine;The super-silent fan outlet is equipped with air processor;Make to produce negative pressure purpose inside preparation room.
As a kind of technical optimization scheme of the present invention, between the flushing 32 between 47 and the sterilizing between be equipped with it is double Door leaf pass-through box.
As a kind of technical optimization scheme of the present invention, the preparation room 1 is equipped with sealing glass with 2 junction of process chamber Glass door 11;There is dangerous leakage in sliding door one end that the process chamber 2 passes in and out, experimentation in the sealed glass door 11 When, break sealed glass door into pieces, and fled to outside laboratory by the double door of process chamber.
It should be noted that other double doors are equipped with entrance guard device in addition to the double door on process chamber is not provided with gate inhibition.
The foregoing is only a preferred embodiment of the present invention, is not intended to limit the invention, for the skill of this area For art personnel, the invention may be variously modified and varied;Within the spirit and principles of the invention, that is made any repaiies Change, equivalent substitution, improvement etc., should all be included in the protection scope of the present invention.

Claims (9)

1. a kind of cell prepares lab design scheme, including preparation room (1), it is characterised in that:The surrounding of the preparation room (1) Logistics room (5), process chamber (2), people's flow chamber (4) and monitoring room (6) are equipped with successively;The monitoring room (6) and the preparation room (1) Between be equipped with the first area in preparation (7);The second area in preparation (3) are equipped between people's flow chamber (4) and the preparation room (1);It is described The internal side adjacent with the process chamber (2) of preparation room (1) is equipped between adjacent culturing room (12) and culture medium preparation (14), The culturing room (12) is adjacent with the logistics room (5), (14) and the second area in preparation (3) phase between prepared by the culture medium It is adjacent;The preparation room (1) is internal to be equipped with sterile room (15) and the 4th buffering with the adjacent side of first area in preparation (7) Between (16), the sterile room (15) is adjacent with the logistics room (5) and culturing room (12), it is described 4th buffering between (16) with The sterile room (15) and the second area in preparation (3) are adjacent, (16) and culturing room (12) and culture medium between the 4th buffering Adjacent washroom (13) and disinfection room (17), the washroom (13) and the sterile room are equipped between preparation between (14) (15) adjacent, the disinfection room (17) is adjacent with second area in preparation (3).
2. a kind of cell according to claim 1 prepares lab design scheme, it is characterised in that the culturing room (12) Double door leafs pass-through box is equipped between being prepared with the culture medium between (14);The sterile room (15) and the washroom (13) it Between be equipped with double door leafs pass-through boxes.
3. a kind of cell according to claim 1 prepares lab design scheme, it is characterised in that people's flow chamber (4) It is internal to be equipped with successively between the first buffering for leading to first area in preparation (7) between (41), changing rooms (42), ultraviolet sterilization (43) With the first air lock (44);People's flow chamber (4) is internal to be also equipped with towards between the second buffering of second area in preparation (3) successively (45), (47) and the second air lock (48) between rinsing;It is described second buffering between (45) with it is described first buffer between (41), changing rooms (42) (43) are adjacent between ultraviolet sterilization, and (45) opposite side is equipped with dry house (46) between second buffering, between the flushing (47) (45) and dry house (46) are adjacent between the second buffering, second air lock (48) and first air lock (44) and Second area in preparation (3) is adjacent.
4. a kind of cell according to claim 1 prepares lab design scheme, it is characterised in that the logistics room (5) Inside is including (51) between material conveying and between material conveying between (51) adjacent cellular identification (52);The cellular identification Between (52) opposite side be connected between the preparation (1) and the first area in preparation (7) adjacent cell storeroom (53);The material (51) bottom is equipped with double door between material conveying;It is equipped with side by side between (52) between (51) and the cellular identification between the material conveying Two double door leafs pass-through boxes;(52) side is equipped between the 3rd buffering (521) between the cellular identification;Between 3rd buffering (521) Double door equipped with (521) between the 3rd buffering that comes in and goes out;(52) and the cell storeroom (53) between the cellular identification Between be equipped with sliding door;Double door leafs pass-through box is equipped between the cell storeroom (53) and the sterile room (15).
5. a kind of cell according to claim 1 prepares lab design scheme, it is characterised in that the monitoring room (6) Adjacent side uses glass wall construction with first area in preparation (7).
6. a kind of cell according to claim 3 prepares lab design scheme, it is characterised in that second area in preparation (3) side adjacent with the process chamber (2) is equipped with (32) between sterilizing in;(32) and the processing between the sterilizing Room is connected between (2) by sliding door;The culture medium is equipped with double door leafs between preparing between (32) between (14) and the sterilizing Pass-through box.
7. a kind of cell according to claim 1 prepares lab design scheme, it is characterised in that the preparation room (1) The super-silent wind turbine of indoor generation negative pressure can be made by being internally provided with;The super-silent fan outlet is equipped with air processor.
8. a kind of cell according to claim 6 prepares lab design scheme, it is characterised in that between the flushing (47) Double door leafs pass-through box is equipped between (32) between the sterilizing.
9. a kind of cell according to claim 1 prepares lab design scheme, it is characterised in that the preparation room (1) Sealed glass door (11) is equipped with the process chamber (2) junction;The sealed glass door (11) close to the process chamber (2) into The sliding door one end gone out.
CN201711387341.9A 2017-12-20 2017-12-20 Cell preparation laboratory design scheme Active CN107965167B (en)

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CN107965167B CN107965167B (en) 2019-05-10

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114829719A (en) * 2019-12-16 2022-07-29 科奥利浦思株式会社 Apparatus and method for manufacturing article using the same

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Publication number Priority date Publication date Assignee Title
CN2509287Y (en) * 2001-12-17 2002-09-04 钟毓秀 Assembling standard purifying working room
CN101619285A (en) * 2009-07-15 2010-01-06 闫铭杰 Production platform system of human body fluid and tissue cells
HU230312B1 (en) * 2013-11-27 2015-12-28 Honvédelmi Minisztérium Elektronikai, Logisztikai és Vagyonkezelő Zártkörűen Működő Részvénytársaság Container with a self- supporting, expansionable frame-structure for a lab
CN105909000A (en) * 2016-05-31 2016-08-31 四川川净洁净技术股份有限公司 People stream/material stream sterile airlock chamber
JP2017055728A (en) * 2015-09-18 2017-03-23 憲隆 福永 Cell culture room and culture facility
CN206290019U (en) * 2016-12-26 2017-06-30 中南大学 A kind of new cell culture chamber
AU2017230823A1 (en) * 2016-03-10 2018-09-27 Lonza Ltd Customizable facility

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2509287Y (en) * 2001-12-17 2002-09-04 钟毓秀 Assembling standard purifying working room
CN101619285A (en) * 2009-07-15 2010-01-06 闫铭杰 Production platform system of human body fluid and tissue cells
HU230312B1 (en) * 2013-11-27 2015-12-28 Honvédelmi Minisztérium Elektronikai, Logisztikai és Vagyonkezelő Zártkörűen Működő Részvénytársaság Container with a self- supporting, expansionable frame-structure for a lab
JP2017055728A (en) * 2015-09-18 2017-03-23 憲隆 福永 Cell culture room and culture facility
AU2017230823A1 (en) * 2016-03-10 2018-09-27 Lonza Ltd Customizable facility
CN105909000A (en) * 2016-05-31 2016-08-31 四川川净洁净技术股份有限公司 People stream/material stream sterile airlock chamber
CN105909000B (en) * 2016-05-31 2018-06-05 四川川净洁净技术股份有限公司 Between the sterile gas lock of the stream of people/logistics
CN206290019U (en) * 2016-12-26 2017-06-30 中南大学 A kind of new cell culture chamber

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114829719A (en) * 2019-12-16 2022-07-29 科奥利浦思株式会社 Apparatus and method for manufacturing article using the same

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