CN107965174A - A kind of Animal Lab. process layout design - Google Patents
A kind of Animal Lab. process layout design Download PDFInfo
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- CN107965174A CN107965174A CN201711237328.5A CN201711237328A CN107965174A CN 107965174 A CN107965174 A CN 107965174A CN 201711237328 A CN201711237328 A CN 201711237328A CN 107965174 A CN107965174 A CN 107965174A
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- E—FIXED CONSTRUCTIONS
- E04—BUILDING
- E04H—BUILDINGS OR LIKE STRUCTURES FOR PARTICULAR PURPOSES; SWIMMING OR SPLASH BATHS OR POOLS; MASTS; FENCING; TENTS OR CANOPIES, IN GENERAL
- E04H5/00—Buildings or groups of buildings for industrial or agricultural purposes
- E04H5/08—Buildings or groups of buildings for agricultural purposes
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Abstract
The invention discloses a kind of design of Animal Lab. process layout, isolation barrier is carried out its main feature is that flowing in each function room by the stream of people, logistics and animal using the clean aisle and pollution aisle that are arranged in parallel, contaminated area, clean area and the process layout in back work area are formed, animal feeding room, experimental implementation room, zootomy room are set in the contaminated area；Animal quarantine room is set in the clean area, clean deposits room；Animal receiving chamber, filth disposal room and cleaning/disinfection room are set in the back work area.It is clear and definite that the present invention has each function division compared with prior art, facilitate environment, the stream of people, logistics and dirt stream controlled, floor space is small, logistics is reasonable, more convenient operation, is especially suitable for the experiment of teaching and research, efficiently solves cross contamination, especially to (b2) the animal organism security laboratory engineering constructions of ABSL 2, there is certain directive significance.
Description
Technical field
It is specifically a kind of real applied to the animal of scientific experiment and research the present invention relates to architectural design technical field
Yan Shi process layouts design.
Background technology
ABSL-2 (b2) experimental animal is widely used in modern science experiment and research, is the dissection because Some Animals
The medicine such as, physiology, Medicine and Surgery mechanism and people are identical, safety testing, effectiveness experiment and the standard for also having it to possess
Property three big purposes of experiment, in bioengineering, heredity, immune, tumour health, health care, family planning, environmental protection, agriculture and animal husbandry
Industry, military medicine, space medicine tip subject in be considered as " precision instrument living " and " reagent living ".Animal organism safety
ABSL-2 (b2) laboratory, is made of infection experiment contaminated area, infection experiment clean area, back work area, isolating device, it is led
Laboratory（Also referred to as core space）Environmental requirement：Clean rank, rate of ventilation, the minimum differntial pressure of relative atmospheric and outdoor direction
The upper adjacent minimum differntial pressure for communicating room（Pa）, humiture, noise, average illumination, the tightness of building enclosure, national standard
《Experimental animal environment and facility》(GB14925-2010) there is clear and definite standard requirement.ABSL-2 (b2) animal houses laboratory, it is real
Test and negative pressure state is in the guard plot of room, main laboratory air-flow pressure force value is minimum, keeps the gas of laboratory internal and will not leak
Polluted to outside.But how infection experiment contaminated area, infection experiment clean area, miscellaneous function general area each function room
Between, function aisle, isolating device technology layout, build a scientific and reasonable relative position relation, and then realize and protect
The zoogenetic infection laboratory core space environmental requirement of card standard requirement, while meet workflow and GLP laboratories again
General requirement.
The process layout in animal organism safe ABSL-2 (b2) laboratory of the prior art is multifarious, disorderly and unsystematic, respectively
Relative position between function room and isolating device is arbitrarily laid out, and can not meet that zoogenetic infection laboratory core space environment will
Summation workflow, it is indefinite there is subregion, different degrees of cross contamination is be easy to cause, does not meet GLP (excellent experiments
Room specification）The requirement of laboratory barrier environment, and the gas of laboratory internal can also leak into outside and pollute.
The content of the invention
The purpose of the present invention is a kind of Animal Lab. process layout design of offer in view of the deficiencies of the prior art, adopt
Each function room of zoopery is subjected to isolation barrier by the stream of people, logistics and animal stream with clean and pollution aisle, composition has
The laboratory environment barrier technique of scientific and reasonable layout, and the clear and definite technological design of each function division, empirically flow is from thing
The clean area to infection experiment, Polluted area are gradually transitions filth disposal successively in the back work region in stream area and stream of people area,
Facilitate controlled environment, facilitate that the stream of people, logistics and dirt stream are controlled, and securely and reliably, not only floor space is small, and logistics is reasonable, and
More convenient operation, is especially suitable for the experiment of clinical, diagnosis, teaching and research, investment reduction, further improves economic benefit, has
Solve that ABSL-2 (b2) animal organisms security laboratory technology subregion is indefinite, disorderly and unsystematic, stream pressure is terraced to effect
Degree have flaw, there are cross contamination, overall not meet GLP (excellent laboratory practices）Laboratory barrier environment requirement etc. is asked
Topic, to ABSL-2 (b2) animal organism security laboratory engineering constructions, has certain directive significance.
The object of the present invention is achieved like this：A kind of Animal Lab. process layout design, its main feature is that using parallel
Each function room of zoopery is carried out isolation barrier by the clean aisle and pollution aisle of setting by the stream of people, logistics and animal stream,
Infection experiment contaminated area, infection experiment clean area and the clear and definite process layout of function division of three, back work area are formed, it is described
Infected animal receptacle, infection experiment operating room, infected animal dissecting room, buffering are set in infection experiment contaminated area
Between and pollution aisle；Animal quarantine room is set in the infection experiment clean area, clean deposits the more room of room, two and clean aisle；
Animal receiving chamber, filth disposal room, shower room, a more room, cleaning/disinfection room and cleaning is set to walk in the back work area
Road and logistics corridor；The infected animal receptacle and infection experiment operating room are to be disposed in parallel in clean aisle and pollution
The centre in aisle；The animal receiving chamber, animal quarantine room and the clean room of depositing are to be disposed in parallel in clean aisle on one side；The infection
Aisle is polluted on one side in experimental animal dissecting room and filth disposal room to be disposed in parallel in；Cleaning/the disinfection room is horizontally installed on
Animal receiving chamber, animal quarantine room and the clean room of depositing are on one side；Walked by the more room of shower room, one and two more rooms and cleaning in the pollution aisle
Road connects；The filth disposal room is by logistics corridor along infection experiment contaminated area and infection experiment clean area outside with cleaning/disappearing
Malicious room connection；Pollution aisle one end is arranged between the buffering and is connected with shower room；It is high that the cleaning/disinfection room is equipped with double door leafs
Pressure autoclave and pass-through box deposit room alternating transmission with clean；The infected animal dissecting room is equipped with another double door leaf high-pressure sterilizing pots
With pass-through box and filth disposal room alternating transmission；The animal receiving chamber interacts biography equipped with another pass-through box with animal quarantine room
It is defeated.
The infection experiment contaminated area, infection experiment clean area and the stream pressure in back work area are set for gradient, its
Animal quarantine room, the clean room and the stream pressure of two more rooms of depositing are -15Pa；Shower room and the stream pressure in clean aisle are -30Pa；
Stream pressure between infected animal receptacle, infection experiment operating room and buffering is -45Pa；Pollute the stream pressure in aisle
For -60Pa；The stream pressure of infected animal dissecting room is -75Pa.
Cleaning/the disinfection room is equipped with cleaning sink and safety door.
Described one more room is equipped with personnel's entrance in disengaging laboratory.
The animal receiving chamber is equipped with the animal entrance in disengaging laboratory.
The filth disposal room is equipped with the article/animal entrance in disengaging laboratory.
It is clear and definite that the present invention has each function division compared with prior art, facilitates environment, the stream of people, logistics and dirt stream controlled,
Floor space is small, and logistics is reasonable, more convenient operation, is especially suitable for the experiment of clinical, diagnosis, teaching and research, securely and reliably, section
About invest, further improve economic benefit, efficiently solve cross contamination, it is especially real to ABSL-2 (b2) animal organism safety
Room engineering construction is tested, there is certain directive significance.
Brief description of the drawings
Fig. 1 is process layout's schematic diagram of the present invention；
The experiment flow schematic diagram of Fig. 2 present invention.
Embodiment
Refering to attached drawing 1, empirically room technique is divided into infection experiment contaminated area I, infection experiment clean area II and auxiliary to the present invention
Help workspace III, between three functional areas order close to being connected, and equipped with personnel's entrance 21, animal entrance 22, article/
Animal entrance 23 and safety door 24, from the air pressure gradient of contaminated area → clean area → auxiliary region successively from negative pressure -75Pa
To 0Pa, it is stepped up, and is respectively equipped with personnel's entrance 21, animal entrance 22 and article/animal entrance 23 and safety
Door 24.The infection experiment contaminated area I is by infected animal receptacle 4, infection experiment operating room 5, infected animal solution
Cut open 17 compositions between room 6, pollution aisle 12 and buffering；The infection experiment clean area II by animal quarantine room 2, clean deposit room 3, two more
Room 10 and clean aisle 11 form；The back work area III is by animal receiving chamber 1, filth disposal room 7,8, one more room of shower room
9th, cleaning/disinfection room 13 and logistics corridor 18 form；The cleaning aisle 11, to be arranged in parallel, is set among it with pollution aisle 12
There are the infected animal receptacle 4 and infection experiment operating room 5 being set up in parallel；The animal receiving chamber 1, animal quarantine room 2
It is to be disposed in parallel in clean aisle 11 on one side with clean room 3 of depositing；The infected animal dissecting room 6 and filth disposal room 7 is simultaneously
Row are arranged on pollution aisle 12 on one side；Cleaning/the disinfection room 13 is horizontally installed on animal receiving chamber 1, animal quarantine room 2 and clean
Deposit room 3 on one side；The pollution aisle 12 is connected by the more more room 10 of room 9 and two of shower room 8, one with clean aisle 11；The cleaning/
Disinfection room 13 is connected by logistics corridor 18 along infection experiment contaminated area I and the outside of infection experiment clean area II with filth disposal room 7；
The clean room 3 of depositing is equipped with double door leafs high-pressure sterilizing pot 14 and pass-through box 15 and 13 alternating transmission of cleaning/disinfection room；The infection experiment
Zootomy room 6 is equipped with another double door leaf high-pressure sterilizing pots 14 and pass-through box 15 and 7 alternating transmission of filth disposal room；The animal connects
Another pass-through box 15 and 2 alternating transmission of animal quarantine room are equipped with by room 1；The stream pressure of the infection experiment contaminated area I is with reality
Test room barrier environment requirement gradually to set to infection experiment clean area II and back work field gradient, the dissection of its infected animal
The stream pressure of room 6 is -75Pa；The stream pressure for polluting aisle 12 is -60Pa；Infected animal receptacle 4, infection experiment
17 stream pressure is -45Pa between operating room 5 and buffering；Shower room 8 and the stream pressure in clean aisle 11 are -30Pa；Animal
Quarantine room 2, the clean stream pressure for depositing the more room 10 of room 3 and two are -15Pa；Cleaning/the disinfection room 13 is equipped with 16 He of cleaning sink
Safety door 24；The pollution aisle 12 leads to shower room 8 by between buffering 17；Described one more room 9 is equipped with the personnel in disengaging laboratory
Entrance 21；The animal receiving chamber 1 is equipped with the animal entrance 22 in disengaging laboratory；The filth disposal room 7 is equipped with disengaging
The article in laboratory/animal entrance 23.
Refering to attached drawing 2, the present invention carries out scientific and reasonable, safe and reliable layout to three functional areas of experiment, makes
" stream of people ", " logistics " and " dirt stream " each Zou Qi roads are simultaneously clear, realize the animal with simultaneously effective guarantee requirements of the national standard
Biocontainment laboratory core space environmental requirement, while meet detection workflow again, meet that the totality in GLP laboratories will
Ask, experimenter carries out animal detection and experiment by the workflow of following personnel, animal and article stream.
Personnel flow：Experimenter enters two more rooms 10 by the personnel's entrance 21 for passing in and out laboratory, after dressing work clothes, cap
Infection experiment operating room 5 is sequentially entered by clean aisle 11, and laboratory animal breeding room is respectively enterd by infection experiment operating room 5
4th, aisle 12 and infected animal dissecting room 6 are polluted, enters shower room for buffered 17 by polluting aisle 12 after experiment
8, laboratory is walked out by personnel's entrance 21 after changing one's clothes after shower into a more room 9.
Animal is flowed：Animal for research then enters animal receiving chamber 1 by animal entrance 22, and enters animal by pass-through box 15
Quarantine room 2, the animal through quarantine sequentially enter infection experiment operating room 5, infected animal receptacle 4 by clean aisle 11
With infected animal dissecting room 6, the animal after experiment enters filth disposal room 7 after double door leafs high-pressure sterilizing pot 14 sterilizes, and
Laboratory is transported by article/animal entrance 23.
Article stream：Experiment article is then entered by article/animal entrance 23, and is gone out by logistics corridor 18 through double door leafs high pressure
Bacterium pot 14 and pass-through box 15 are sent into clean room 3 of depositing and are stored, and sequentially enter infection experiment operating room 5 by clean aisle 11 during use,
And entering infected animal dissecting room 6 by polluting aisle 12, the article after experiment is through double door leafs high-pressure sterilizing pot 14 and transmits
Window 15 enters filth disposal room 7, and transports laboratory by article/animal entrance 23.
Air pressure of the invention from infection experiment contaminated area I → infection experiment, II → back work of clean area area III is successively
The gradient being stepped up from negative pressure -75Pa to 0Pa is set, and facilitates controlled environment, facilitates personnel's stream, article stream, animal stream controlled,
Securely and reliably.Infected animal receptacle 4, infection experiment operating room 5 and infected animal in infection experiment contaminated area I
Dissecting room 6 is also referred to as between core work for main laboratory, is the region of direct operational hazards biotic factor, and infection experiment is operated in life
Carried out in thing safety cabinet, infectious animal feeding is placed in animal xegregating unit, infection experiment dissection is on negative pressure dissecting platform
Carry out, it is indoor not easy to pollute, but have the possibility seriously polluted, clean 7 grades or 8 grades of rank requirement.The dirt that infection experiment produces
Rubbish, spoil etc. clean out infection experiment contaminated area I after double door leafs high-pressure sterilizing pot 14 sterilizes, and zoopery raising is used
Cage tool returns to cleaning/disinfection room 13 after double door leafs high-pressure sterilizing pot 14 sterilizes, through logistics corridor 18, is repeated after cleaned, disinfection
Use.Assistant experiment and the region of decay pollution, its air-flow is in animal quarantine room 2, clean room 3 of depositing in infection experiment clean area II
Pressure is higher than infection experiment contaminated area I, and normal operating is generally not susceptible to the pollution of the experiment factor, but there are potential pollution can
Energy.Animal receiving chamber 1, filth disposal room 7, the more room 9 of shower room 8, one in back work area III, clean aisle 11 and cleaning/
Disinfection room 13 is personnel, article, the region of animal disengaging, and the pollution of any experiment factor, people will not occur in normal operating
Member special need not can protect.The present invention presses the phase of " ABSL-2 (b2) animal organisms security laboratory barrier environment technology "
Three functional areas of experiment are carried out scientific and reasonable, safe and reliable layout by pass standard and code requirement, make " stream of people ",
Each Zou Qi roads of " logistics " and " dirt stream " are simultaneously clear.
More than simply the present invention is further illustrated, to the clean rank inside each function room, wind pressure, warm and humid
Degree, rate of ventilation, water, electricity, room height, illumination, finishing material, equipment the content such as are put and are not reflected, it is intended to solve reader hair
Bright technical solution, and it is not used to limitation this patent, all claims for being equivalence enforcement of the present invention, being intended to be limited solely by this patent
Within the scope of.
Claims (6)
1. a kind of Animal Lab. process layout design, it is characterised in that will using the clean aisle and pollution aisle that are arranged in parallel
Each function room of zoopery carries out isolation barrier, composition infection experiment contaminated area, infection experiment by the stream of people, logistics and animal stream
Clean area and the clear and definite process layout of function division of three, back work area, infection experiment is set in the infection experiment contaminated area
Between animal feeding room, infection experiment operating room, infected animal dissecting room, buffering and pollution aisle；The infection experiment
Animal quarantine room is set in clean area, clean deposits the more room of room, two and clean aisle；Animal is set to receive in the back work area
Room, filth disposal room, shower room, a more room, cleaning/disinfection room and clean aisle and logistics corridor；The infection experiment moves
Thing receptacle and infection experiment operating room are to be disposed in parallel in clean aisle with polluting the centre in aisle；The animal receiving chamber,
Animal quarantine room and the clean room of depositing are to be disposed in parallel in clean aisle on one side；The infected animal dissecting room and filth disposal room
To be disposed in parallel in pollution aisle on one side；Cleaning/the disinfection room is horizontally installed on animal receiving chamber, animal quarantine room and clean deposits
Room is on one side；The pollution aisle is connected by the more room of shower room, one and two more rooms with clean aisle；The filth disposal room is by logistics
Passage is connected along on the outside of infection experiment contaminated area and infection experiment clean area with cleaning/disinfection room；Dirt is arranged between the buffering
Contaminate aisle one end and connected with shower room；Cleaning/the disinfection room is equipped with double door leaf high-pressure sterilizing pots and pass-through box and is handed over the clean room of depositing
Mutually transmission；The infected animal dissecting room is equipped with another double door leaf high-pressure sterilizing pots and pass-through box interacts biography with filth disposal room
It is defeated；The animal receiving chamber is equipped with another pass-through box and animal quarantine room alternating transmission.
2. Animal Lab. process layout designs according to claim 1, it is characterised in that the infection experiment contaminated area, sense
Dye experiment clean area and the stream pressure in back work area are set for gradient, its animal quarantine room, the clean gas for depositing room and two more rooms
Flowing pressure is -15Pa；Shower room and the stream pressure in clean aisle are -30Pa；Infected animal receptacle, infection experiment behaviour
The stream pressure made between room and buffering is -45Pa；The stream pressure for polluting aisle is -60Pa；Infected animal dissecting room
Stream pressure is -75Pa.
3. Animal Lab. process layout designs according to claim 1, it is characterised in that the cleaning/disinfection room is equipped with clear
Wash water groove and safety door.
4. according to claim 1 Animal Lab. process layout design, it is characterised in that the filth disposal room be equipped with into
Go out the article/animal entrance in laboratory.
5. Animal Lab. process layout designs according to claim 1, it is characterised in that it is real that described one more room is equipped with disengaging
Test personnel's entrance of room.
6. according to claim 1 Animal Lab. process layout design, it is characterised in that the animal receiving chamber be equipped with into
Go out the animal entrance in laboratory.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711237328.5A CN107965174A (en) | 2017-11-30 | 2017-11-30 | A kind of Animal Lab. process layout design |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711237328.5A CN107965174A (en) | 2017-11-30 | 2017-11-30 | A kind of Animal Lab. process layout design |
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| Publication Number | Publication Date |
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| CN107965174A true CN107965174A (en) | 2018-04-27 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201711237328.5A Pending CN107965174A (en) | 2017-11-30 | 2017-11-30 | A kind of Animal Lab. process layout design |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108990812A (en) * | 2018-10-12 | 2018-12-14 | 中国科学院深圳先进技术研究院 | A kind of animal group rearing room |
| CN109184268A (en) * | 2018-09-18 | 2019-01-11 | 中船第九设计研究院工程有限公司 | A kind of PCR Lab with barrier of environment |
| CN111809923A (en) * | 2020-07-03 | 2020-10-23 | 辽宁益康生物股份有限公司 | Biological safety forced shower system |
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2017
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109184268A (en) * | 2018-09-18 | 2019-01-11 | 中船第九设计研究院工程有限公司 | A kind of PCR Lab with barrier of environment |
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| CN111809923A (en) * | 2020-07-03 | 2020-10-23 | 辽宁益康生物股份有限公司 | Biological safety forced shower system |
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Application publication date: 20180427 |