CN201473515U - Platform system for producing cells of human body fluid and tissues - Google Patents
Platform system for producing cells of human body fluid and tissues Download PDFInfo
- Publication number
- CN201473515U CN201473515U CN 200920167201 CN200920167201U CN201473515U CN 201473515 U CN201473515 U CN 201473515U CN 200920167201 CN200920167201 CN 200920167201 CN 200920167201 U CN200920167201 U CN 200920167201U CN 201473515 U CN201473515 U CN 201473515U
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- Prior art keywords
- body fluid
- room
- clean
- platform system
- chamber
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M39/00—Means for cleaning the apparatus or avoiding unwanted deposits of microorganisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
Abstract
The utility model relates to the technical field of clean rooms, in particular to a platform system for producing the cells of human body fluid and tissues. A laundry room, a preparation room and a program-controlled refrigerating instrument room are arranged in the platform system, consequently, clean clothing, laboratory appliance carts and separated cells can be prevented from being contaminated in the process of transportation outside the platform system, and the clean coefficient of the platform system is increased; height-adjustable fan filter units are arranged in separation rooms, so that the platform system is applicable to the separation of cells in body fluid as well as to the separation of cells in tissues; the independent preparation room and the separation rooms independent from one another solve the problem of cross infection in the process of the separation of different types of cells, and furthermore, the independent preparation room ensures the distribution efficiency of the separation rooms; and because a secondary changing room and an air-conditioning air draft system and sterile clean high-efficiency air inlets are arranged in the platform system, the contact between the clean platform and outside pollution can be obstructed.
Description
Technical field
The utility model relates to the clean dust-free room technical field, and the production platform system of cellular segregation in the cellular segregation and body fluid specifically is provided in a kind of can the organizing within it.
Background technology
Sound the perfect of medical and health rules that reach along with state's laws, country will be tending towards strictness and standard to the use of clinical grade cell product, the raising of the level of hospital management simultaneously also impels the service requirements of clinical hospital pair cell goods and stem cell transplantation also more and more higher.At present, in existing document and technical information, do not have as yet to be specifically designed to and be applied to the clinical isolating GMP of extensive stem cell (Good ManufacturingPractice) platform design.Present existing stem cell separates that the GMP platform design is according to pharmacy requirement design, exist spatial design to be not suitable for tissue culture work, only be applicable to separately that histocyte separates or body fluid cell separates, necessary defectives such as cell save set of design, the stem cell GMP platform that not only had been fit to cellular segregation in the body fluid but also had been fit to cellular segregation in the tissue does not appear in the newspapers as yet.
The utility model content
The technical problems to be solved in the utility model is the rational Design on Plane by clean platform internal structure, improve the cleanliness factor of clean platform, people's body fluid, the histocyte production platform system of cellular segregation in the cellular segregation and body fluid are provided in a kind of can the organizing within it.
For reaching above utility model purpose, plateform system of the present utility model comprises secondary dressing cubicle, material transfer chamber, sample transfer chamber, preparation room, laundry room, waste outlet, program control cooling instrument chamber, the separate chamber that at least one is separate, each chamber all is connected with clean passageway, is provided with exhausting air-conditioning system and the efficient air port of aseptic uncontaminated air in the plateform system.
The personnel that described secondary dressing cubicle is used to enter plateform system change one's clothes, sterilize, and comprise Changing Room, first dressing cubicle, first lavatory, second dressing cubicle, second lavatory, disinfection room from outside to inside successively, and disinfection room is connected with described clean passageway.Described first lavatory, second dressing cubicle, second lavatory, disinfection room are equipped with the wind shower device, and interior external door can not be opened simultaneously.Personnel change at Changing Room and wear inner shoes, enter first dressing cubicle and change inner clothes, enter first lavatory and wash one's hands, enter second dressing cubicle and change inner clothes once more, enter second lavatory and wash one's hands once more, enter and to enter described clean passageway after disinfection room is put on clean garment and adversary's sterilization.
Described material transfer chamber is used for outside material and enters plateform system, comprise successively from outside to inside between registration, between buffering, pass-through, described pass-through comprises the interior exterior window that can not open simultaneously, is provided with the wind shower device between described buffering.Material enters sterilization between buffering, dedusting, cleaning after entering and putting on record between registration, is passed to described clean passageway by pass-through.
The outside sample that described sample transfer chamber is used for relative clean enters plateform system, comprises successively from outside to inside between the transmission of pass-through and sample; Described sample pass-through comprises the interior exterior window that can not open simultaneously; Comprise wind shower device and sterilizing unit between described sample transmission.Outside sample is sent between the sample transmission through pass-through, after registration, sterilization, cleaning, from delivering to described clean passageway between the sample transmission.
Described preparation room is used for cleaning and stores cell separation equipment in experiment apparatus car, tissue cell separation equipment, the body fluid, comprise that cleaning shop and cleaning appliance store between, be equipped with the wind shower device.Cleaning shop is provided with the water source and is used for cleaning apparatus; Between storing, cleaning appliance is used to store clean utensil and preparing experiment.
Described laundry room is used for cleaning, the used inner clothes of sterilization, clean garment, comprises the arrangement disinfection room that the cleaning shop that is connected with described clean passageway is connected with disinfection room with described secondary dressing cubicle.Inner clothes, clean garment by comprising the pass-through of the interior exterior window that can not open simultaneously, are passed to disinfection room for use through after cleaning, sterilizing.
Described waste outlet is connected with described clean passageway with the shared buffer zone in described program control cooling instrument chamber; Indoor liquid nitrogen transfer tank, Ultralow Temperature Freezer and the program control cooling instrument of being provided with of described program control cooling instrument is used for the cell after the frozen separation.
Described separate chamber is used for cellular segregation in body fluid cellular segregation or the tissue, and the place, diagonal angle apart from 2.5 meters at door in the separate chamber is provided with height adjustable hundred grades of laminar flow hood; The experiment apparatus car that cell separation equipment in the body fluid is installed placed under hundred grades of laminar flow hood can carry out the body fluid cellular segregation, the experiment apparatus car that cell separation equipment in the tissue is installed is placed under hundred grades of laminar flow hood can organize cellular segregation.
Preferably, to be provided with a diameter be 0.5 centimetre ventilation hole on every square centimeter of surface of the operator's console of cell separation equipment in the described body fluid.
Preferably, the super clean bench blast inlet of cell separation equipment upwards forms downward laminar flow over against hundred grades of laminar flow hood in the described tissue.
Plateform system of the present utility model inside is provided with laundry room, preparation room and program control cooling instrument chamber, avoided clean garment, experiment apparatus car and separates after cell contaminated in plateform system transportation in addition, improved the cleanliness factor of plateform system; Be provided with height adjustable hundred grades of laminar flow hood in the separate chamber, make plateform system both be fit to cellular segregation in the body fluid, also be fit to cellular segregation in the tissue; Independent preparation room, separate separate chamber have solved the cross-contamination issue in the dissimilar cellular segregation, and independent preparation room has more been guaranteed the dispensing efficient of separate chamber; The use of secondary dressing cubicle separates the stream of people with logistics, fully intercept the external contamination source; Be provided with exhausting air-conditioning system and the efficient air port of aseptic uncontaminated air in the plateform system, guaranteed that the pollutent that grows is discharged beyond the clean platform in time.
Further specify technical solutions of the utility model below in conjunction with the drawings and the specific embodiments.
Description of drawings
Fig. 1 is the two dimensional structure synoptic diagram of plateform system of the present utility model.
Among the figure, the part sign represents that respectively implication is:
M1, expression door 1; M2, expression door 2; M3, expression door 3;
F500 represents efficient air port GKF-5I, nominal air delivery 500m/h;
F700 represents efficient air port GKF-7I, nominal air delivery 700m
3/ h;
F1000 represents efficient air port GKF-10I, nominal air delivery 1000m
3/ h;
F3000 represents efficient air port GKF-30I, nominal air delivery 3000m
3/ h.
Embodiment
As shown in Figure 1, plateform system of the present utility model comprises secondary dressing cubicle, material transfer chamber, sample transfer chamber, preparation room, laundry room, waste outlet, program control cooling instrument chamber, 4 separate separate chambers, each chamber all is connected with clean passageway, is provided with exhausting air-conditioning system and the efficient air port of aseptic uncontaminated air in the plateform system.
The personnel that described secondary dressing cubicle is used to enter plateform system change one's clothes, sterilize, be divided into two groups of men and women, every group comprises Changing Room, first dressing cubicle, first lavatory, second dressing cubicle, second lavatory, disinfection room from outside to inside successively, and disinfection room is connected with described clean passageway.Described first lavatory, second dressing cubicle, second lavatory, disinfection room are equipped with the wind shower device, and interior external door can not be opened simultaneously, are respectively equipped with efficient air port F500, F700, F700, F1000.Personnel enter from door 1, change at Changing Room and to wear inner shoes, enter first dressing cubicle and change inner clothes, entering first lavatory washes one's hands, enter second dressing cubicle and change inner clothes once more, enter second lavatory and wash one's hands once more, enter and to enter described clean passageway after disinfection room is put on clean garment and adversary's sterilization.
Described material transfer chamber is used for outside material and enters plateform system, comprise successively from outside to inside between registration, between buffering, pass-through, described pass-through comprises the interior exterior window that can not open simultaneously, is provided with the wind shower device between described buffering, is provided with efficient air port F500.Material enters sterilization between buffering, dedusting, cleaning after entering and putting on record between registration, is passed to described clean passageway by pass-through.
The outside sample that described sample transfer chamber is used for relative clean enters plateform system, comprises successively from outside to inside between the transmission of pass-through and sample; Described sample pass-through comprises the interior exterior window that can not open simultaneously; Comprise wind shower device and sterilizing unit between described sample transmission, be provided with efficient air port F500.Outside sample is sent between the sample transmission through pass-through, after registration, sterilization, cleaning, from delivering to described clean passageway between the sample transmission.
Described preparation room is used for cleaning and stores cell separation equipment in experiment apparatus car, tissue cell separation equipment, the body fluid, quantity has 2 preparation rooms, wherein one be provided with the door can be in communication with the outside, between each preparation room comprises that cleaning shop and cleaning appliance store, be equipped with the wind shower device, be respectively equipped with efficient air port F1000.
Described laundry room is used for cleaning, the used inner clothes of sterilization, clean garment, comprises the arrangement disinfection room that the cleaning shop that is connected with described clean passageway is connected with disinfection room with described secondary dressing cubicle, is respectively equipped with efficient air port F1000.Inner clothes, clean garment by comprising the pass-through of the interior exterior window that can not open simultaneously, are passed to disinfection room for use through after cleaning, sterilizing.
Described waste outlet is connected with described clean passageway with the shared buffer zone in described program control cooling instrument chamber, is provided with efficient air port F500 in the buffer zone; Indoor liquid nitrogen transfer tank, Ultralow Temperature Freezer and the program control cooling instrument of being provided with of described program control cooling instrument is used for the cell after the frozen separation.
Described 4 separate chambers are separate, each separate chamber all can be used for cellular segregation in body fluid cellular segregation or the tissue separately, in each separate chamber, be provided with height adjustable hundred grades of laminar flow hood 2.3 meters apart from ground apart from 2.5 meters place, diagonal angle of door, the length and width degree of hundred grades of laminar flow hood is 3000mm * 2400mm, and is provided with efficient air port F3000; The experiment apparatus car that cell separation equipment in the body fluid is installed placed under hundred grades of laminar flow hood can carry out the body fluid cellular segregation, the operator's console length and width of cell separation equipment are 1700mm * 1700mm in the body fluid, apart from 1.5 meters of hundred grades of laminar flow hood, every square centimeter is provided with 1 diameter is 0.5 centimetre ventilation opening; The experiment apparatus car that cell separation equipment in the tissue is installed placed under hundred grades of laminar flow hood can organize cellular segregation, the super clean bench of cell separation equipment is provided with blast inlet upwards over against hundred grades of laminar flow hood in the tissue, formation is satisfied the working conditions of cellular segregation in the tissue to underflow.
Claims (5)
1. people's body fluid, histocyte production platform system, it is characterized in that: comprise secondary dressing cubicle, material transfer chamber, sample transfer chamber, preparation room, laundry room, waste outlet, program control cooling instrument chamber, the separate chamber that at least one is separate, each chamber all is connected with clean passageway, is provided with exhausting air-conditioning system and the efficient air port of aseptic uncontaminated air in the plateform system;
The personnel that described secondary dressing cubicle is used to enter plateform system change one's clothes, sterilize, and comprise Changing Room, first dressing cubicle, first lavatory, second dressing cubicle, second lavatory, disinfection room from outside to inside successively, and disinfection room is connected with described clean passageway; Described first lavatory, second dressing cubicle, second lavatory, disinfection room are equipped with the wind shower device, and interior external door can not be opened simultaneously;
Described material transfer chamber is used for outside material and enters plateform system, comprise successively from outside to inside between registration, between buffering, pass-through, described pass-through comprises the interior exterior window that can not open simultaneously, is provided with the wind shower device between described buffering;
The outside sample that described sample transfer chamber is used for relative clean enters plateform system, comprises successively from outside to inside between the transmission of pass-through and sample; Described sample pass-through comprises the interior exterior window that can not open simultaneously; Comprise wind shower device and sterilizing unit between described sample transmission;
Described preparation room is used for cleaning and stores cell separation equipment in experiment apparatus car, tissue cell separation equipment, the body fluid, comprise that cleaning shop and cleaning appliance store between, be equipped with the wind shower device;
Described laundry room is used for cleaning, the used inner clothes of sterilization, clean garment, comprises the arrangement disinfection room that the cleaning shop that is connected with described clean passageway is connected with disinfection room with described secondary dressing cubicle;
Described waste outlet is connected with described clean passageway with the shared buffer zone in described program control cooling instrument chamber; Indoor liquid nitrogen transfer tank, Ultralow Temperature Freezer and the program control cooling instrument of being provided with of described program control cooling instrument is used for the cell after the frozen separation;
Described separate chamber is used for cellular segregation in body fluid cellular segregation or the tissue, and the place, diagonal angle apart from 2.5 meters at door in the separate chamber is provided with height adjustable hundred grades of laminar flow hood; The experiment apparatus car that cell separation equipment in the body fluid is installed placed under hundred grades of laminar flow hood can carry out the body fluid cellular segregation, the experiment apparatus car that cell separation equipment in the tissue is installed is placed under hundred grades of laminar flow hood can organize cellular segregation.
2. people's body fluid as claimed in claim 1, histocyte production platform system is characterized in that: to be provided with a diameter be 0.5 centimetre ventilation hole on every square centimeter of surface of the operator's console of cell separation equipment in the described body fluid.
3. people's body fluid as claimed in claim 1, histocyte production platform system is characterized in that: the super clean bench blast inlet of cell separation equipment upwards forms downward laminar flow over against hundred grades of laminar flow hood in the described tissue.
4. people's body fluid as claimed in claim 1, histocyte production platform system is characterized in that: described secondary dressing cubicle is divided into two groups of men and women.
5. people's body fluid as claimed in claim 1, histocyte production platform system is characterized in that: described preparation room quantity has 2 preparation rooms, wherein one be provided with the door can be in communication with the outside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200920167201 CN201473515U (en) | 2009-07-31 | 2009-07-31 | Platform system for producing cells of human body fluid and tissues |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200920167201 CN201473515U (en) | 2009-07-31 | 2009-07-31 | Platform system for producing cells of human body fluid and tissues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201473515U true CN201473515U (en) | 2010-05-19 |
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ID=42409759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200920167201 Expired - Fee Related CN201473515U (en) | 2009-07-31 | 2009-07-31 | Platform system for producing cells of human body fluid and tissues |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201473515U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101619285B (en) * | 2009-07-15 | 2014-08-27 | 闫铭杰 | Production platform system of human body fluid and tissue cells |
| CN106988567A (en) * | 2017-04-24 | 2017-07-28 | 中船第九设计研究院工程有限公司 | A kind of design method of Experiment on Microbiology process layout |
| CN110761594A (en) * | 2019-01-24 | 2020-02-07 | 中船第九设计研究院工程有限公司 | Clinical cell preparation engineering environment barrier system |
-
2009
- 2009-07-31 CN CN 200920167201 patent/CN201473515U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101619285B (en) * | 2009-07-15 | 2014-08-27 | 闫铭杰 | Production platform system of human body fluid and tissue cells |
| CN106988567A (en) * | 2017-04-24 | 2017-07-28 | 中船第九设计研究院工程有限公司 | A kind of design method of Experiment on Microbiology process layout |
| CN106988567B (en) * | 2017-04-24 | 2019-04-02 | 中船第九设计研究院工程有限公司 | A kind of design method of Experiment on Microbiology process layout |
| CN110761594A (en) * | 2019-01-24 | 2020-02-07 | 中船第九设计研究院工程有限公司 | Clinical cell preparation engineering environment barrier system |
| CN110761594B (en) * | 2019-01-24 | 2021-07-09 | 中船第九设计研究院工程有限公司 | Clinical cell preparation engineering environment barrier system |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100519 Termination date: 20120731 |