CN107965167B - Cell preparation laboratory design scheme - Google Patents
Cell preparation laboratory design scheme Download PDFInfo
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- CN107965167B CN107965167B CN201711387341.9A CN201711387341A CN107965167B CN 107965167 B CN107965167 B CN 107965167B CN 201711387341 A CN201711387341 A CN 201711387341A CN 107965167 B CN107965167 B CN 107965167B
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- E—FIXED CONSTRUCTIONS
- E04—BUILDING
- E04H—BUILDINGS OR LIKE STRUCTURES FOR PARTICULAR PURPOSES; SWIMMING OR SPLASH BATHS OR POOLS; MASTS; FENCING; TENTS OR CANOPIES, IN GENERAL
- E04H1/00—Buildings or groups of buildings for dwelling or office purposes; General layout, e.g. modular co-ordination or staggered storeys
- E04H1/12—Small buildings or other erections for limited occupation, erected in the open air or arranged in buildings, e.g. kiosks, waiting shelters for bus stops or for filling stations, roofs for railway platforms, watchmen's huts or dressing cubicles
Abstract
The invention discloses a design scheme of a cell preparation laboratory, which comprises a preparation chamber, wherein a material flow chamber, a treatment chamber, a human flow chamber and a monitoring chamber are sequentially arranged around the preparation chamber; a first preparation area is arranged between the monitoring chamber and the preparation chamber; a second preparation area is arranged between the human flow chamber and the preparation chamber; one side of the interior of the preparation chamber, which is adjacent to the treatment chamber, is provided with an adjacent culture chamber and a culture medium preparation room, the culture chamber is adjacent to the logistics chamber, and the culture medium preparation room is adjacent to the second preparation area; the preparation room is inside to be equipped with between aseptic manipulation room and fourth buffering with the adjacent one side in first preparation district, and aseptic manipulation room is adjacent with commodity circulation room and cultivation room, and the fourth buffering is adjacent with aseptic manipulation room and second preparation district, is equipped with adjacent washing room and disinfection room between fourth buffering room and cultivation room and the culture medium preparation room, and the washing room is adjacent with aseptic manipulation room, and the disinfection room is adjacent with the second preparation district.
Description
Technical field
The invention belongs to architectural design fields；Lab design scheme is prepared more particularly to a kind of cell.
Background technique
With the raising of China's science and technology, cell preparation techniques are also increased accordingly, and cell preparation is used for extensive field；Such as medicine
Object research and development, such as new medicament screen, vaccine, genetically engineered drug, cell engineering Drug development and research, monoclonal antibody preparation
Deng；Basic research, such as drug mechanism, gene function, disease genesis mechanism research；Bio-pharmaceuticals, such as production of vaccine: such as
Viral vaccine (hepatitis virus vaccine, AIDS vaccine etc.), polypeptide vaccine tumor vaccine) etc.；Genetically engineered drug production: such as
EPO etc.；Antibody drug, gene therapy medicament production；The production of cell engineering drug: some bioactivity in biological cell are more
Peptide, bioactive substance etc.；Utilize the activity of cell method external test bioactive substance；And predict its drug effect in vivo and
Substitution in vivo method detects the bioactivity of its finished product；However cell preparation laboratory needs very high requirement, cell preparation experiment
Room is made of main laboratory, auxiliary room, isolating device, and main laboratory is also referred to as the environmental requirement of core space: clean rank,
Rate of ventilation, the minimum differntial pressure of relative atmospheric, the minimum differntial pressure Pa that communicates room adjacent in outdoor direction, temperature and humidity, noise,
Average illumination, the tightness of building enclosure, national standard (GB50346-2011) have clear standard requirements；These rooms and every
Reasonable layout is needed from device, working efficiency could be improved；The layout of the prior art is disorderly and unsystematic, each function room be isolated
Relative position between device is arbitrarily laid out, and is unable to satisfy the workflow and environmental requirement of microcell experiment.
Summary of the invention
In order to solve the problems in the existing technology, the present invention provides a kind of cell preparation lab design scheme.
Specific technical solution of the present invention is as follows:
A kind of cell prepares lab design scheme, including preparation room, the surrounding of the preparation room be successively arranged logistics room,
Process chamber, stream of people room and monitoring room；The first area in preparation is equipped between the monitoring room and the preparation room；The stream of people room and institute
It states and is equipped with the second area in preparation between preparation room；The side adjacent with the process chamber is equipped with adjacent culture inside the preparation room
Between room and culture medium preparation, the culturing room is adjacent with the logistics room, the culture medium prepare between with second area in preparation
It is adjacent；The side adjacent with first area in preparation is equipped between sterile room and the 4th buffering inside the preparation room, described
Sterile room is adjacent with the logistics room and culturing room, it is described 4th buffering between with the sterile room and the second area in preparation
It is adjacent, it is described 4th buffering between culturing room and culture medium preparation between be equipped with adjacent washroom and disinfection room, it is described to wash
Adjacent with the sterile room between washing, the disinfection room is adjacent with second area in preparation.
Optimization, between the culturing room and culture medium preparation between be equipped with double door leafs pass-through boxes；The sterile room
Double door leafs pass-through box is equipped between the washroom.
Optimization, stream of people's chamber interior be successively arranged towards first area in preparation first buffering between, changing rooms, purple
Between outside line sterilization and the first air lock；Stream of people's chamber interior is also successively arranged the second buffering towards second area in preparation
Between, rinse between and the second air lock；Between second buffering between first buffering, phase between changing rooms and ultraviolet light sterilization
Neighbour, it is described second buffering between the other side be equipped with dry house, between the flushing second buffering between and dry house it is adjacent, described second
Air lock is adjacent with first air lock and the second area in preparation.
Optimization, the logistics chamber interior includes cellular identification adjacent between material conveys and between material conveying
Between；The other side is connected with the cell storeroom adjacent with the preparation room and the first area in preparation between the cellular identification；It is described
Bottom is equipped with double door between material conveying；Between material conveying between the cellular identification between set that there are two double door leafs to pass side by side
Pass window；Side is equipped between third buffering between the cellular identification；It is equipped between the third buffering between entering and leaving the third buffering
Double door；Sliding door is equipped between the cellular identification between the cell storeroom；The cell storeroom and the nothing
Double door leafs pass-through box is equipped between bacterium operating room.
Optimization, the monitoring room side adjacent with first area in preparation uses glass wall construction.
Optimization, the side adjacent with the process chamber is equipped between sterilizing in second area in preparation；The sterilization
It is connected between disinfection room and the process chamber by sliding door；Between culture medium preparation between the sterilizing between be equipped with
Double door leaf pass-through boxes.
Optimization, the super-silent blower that can make indoor generation negative pressure is equipped with inside the preparation room；The super-silent blower
Air outlet is equipped with air processor.
Optimization, between the flushing between the sterilizing between be equipped with double door leafs pass-through boxes.
Optimization, the preparation room and the process chamber junction are equipped with sealed glass door；The sealed glass door is close
Sliding door one end of the process chamber disengaging.
Beneficial effects of the present invention are as follows:
The present invention has the stream of people, logistics, dirt stream clear compared with prior art, has a safety feature, and occupied area is small, object
Rationally, production operation is more convenient for stream, and design is complied with standard, standardized, and can meet the experiment of clinical, diagnosis, teaching and research, safety
Reliably, energy-saving and emission-reduction have certain directive significance to biology laboratory engineering construction.
Detailed description of the invention
Fig. 1 is that a kind of cell provided by the invention prepares lab design solution layout figure；
Fig. 2 is that a kind of cell provided by the invention prepares lab design Solution Embodiments figure；
Fig. 3 is that a kind of cell provided by the invention prepares lab design scheme experiment flow figure.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Embodiment 1
Refering to Figure 1, the present invention provides a kind of cell preparation lab design scheme, including preparation room 1, the system
The surrounding of standby room 1 is successively arranged logistics room 5, process chamber 2, stream of people room 4 and monitoring room 6；The monitoring room 6 and the preparation room 1
Between be equipped with the first area in preparation 7；The second area in preparation 3 is equipped between the stream of people room 4 and the preparation room 1；Please refer to Fig. 2 institute
Showing, 1 inside of the preparation room and the adjacent side of the process chamber 2 are equipped with 14 between adjacent culturing room 12 and culture medium preparation,
The culturing room 12 is adjacent with the logistics room 5, and 14 is adjacent with second area in preparation 3 between the culture medium preparation；The system
It is equipped with 16 between sterile room 15 and the 4th buffering for the adjacent side in 1 inside of room and first area in preparation 7, the sterile behaviour
It is adjacent with the logistics room 5 and culturing room 12 to make room 15,16 is quasi- with the sterile room 15 and second between the 4th buffering
Preparation area 3 is adjacent, be equipped between 14 between 16 and culturing room 12 and culture medium preparation between the 4th buffering adjacent washroom 13 and
Disinfection room 17, the washroom 13 is adjacent with the sterile room 15, the disinfection room 17 and 3 phase of the second area in preparation
It is adjacent；The form design that the air pressure inside in house is incremented by centered on preparation room to two sides.
Double door leafs pass-through box is equipped between 14 between the culturing room 12 and culture medium preparation；The sterile room 15 with
Double door leafs pass-through box is equipped between the washroom 13.
Experimenter enters the first area in preparation by stream of people room, enters the 4th buffer area from the first area in preparation, slow from the 4th
Sterile room and washroom can be respectively enterd by rushing area；From culturing room can be entered between sterile working；Disinfection can be entered from washroom
Between；Culture medium preparation room can be entered from disinfection room；Utensil in experiment in sterile room can be sent by double door leaf pass-through boxes to be washed
It is washed between washing, disinfection room disinfection is put into after having washed；Laboratory technician can be from double door leaf pass-through boxes by the culture in culture medium preparation room
Base is sent into culturing room.
Embodiment 2
It please refers to shown in Fig. 2 and Fig. 3, as a kind of technical optimization scheme of the invention, is successively set inside the stream of people room 4
Have towards 41, changing rooms 42 between the first buffering of first area in preparation 7,43 and first air lock 44 between ultraviolet light sterilization；Institute
It states and is also successively arranged inside stream of people room 4 towards 45 between the second buffering of second area in preparation 3,47 and second air lock between rinsing
48；43 adjacent between 41, changing rooms 42 and ultraviolet light sterilization between 45 and first buffering between second buffering, described second is slow
Between punching 45 other sides be equipped with dry house 46, between the flushing 47 and second buffering between 45 and dry house 46 it is adjacent, second gas
Lock chamber 48 is adjacent with first air lock 44 and the second area in preparation 3, and sliding door connection is equipped between connected.
Experimenter be successively arranged inside the stream of people room 4 towards first area in preparation 7 first buffering between 41, then
Into changing rooms 42, clothing is replaced inside changing rooms, puts on protective garment etc., is killed carrying out disinfection between ultraviolet light sterilization 43
Bacterium is entering the first area in preparation 7 by the first air lock 44, is finally entering the work of preparation room 1, be equipped with sliding door between connected
Connection；It after having worked, is come out from preparation room 1 and enters the second area in preparation 3, entering back into the second air lock 48, to carry out preliminary dust clear
It removes；47 will be rinsed between entering flushing, and the article rinsed is sent between sterilizing from the double-deck title page pass-through box；Using
Dry house enters between the second buffering, changes clothes from coming out between the second buffering into changing rooms, checks card after between the first buffering
It gos out.
As a kind of technical optimization scheme of the invention, inside the logistics room 5 include material conveying between 51 and with it is described
Between material conveying 52 between 51 adjacent cellular identifications；52 other sides are connected with and the preparation room 1 and between the cellular identification
Surely the adjacent cell storeroom 53 in preparation area 7；51 bottoms are equipped with double door between the material conveying；51 between the material conveying
Double door leafs pass-through box there are two being set side by side between 52 between the cellular identification；52 sides are buffered equipped with third between the cellular identification
Between 521；Between third buffering 521 be equipped with enter and leave the third buffering between 521 double door；Between the cellular identification 52 with
Sliding door is equipped between the cell storeroom 53；Double door leafs are equipped between the cell storeroom 53 and the sterile room 15
Pass-through box.
Logistics personnel from materials handling is reflected to material is sent to cell by double door leaf pass-through boxes in 51 material conveying
Fixed interior carry out cellular identification；It is sent into cell storeroom after cellular identification is complete and carries out classification storage；The material of cell storeroom
The first area in preparation can be passed to by double door leaf pass-through boxes.
As a kind of technical optimization scheme of the invention, the monitoring room 6 side adjacent with first area in preparation 7 is adopted
With glass wall construction.
As a kind of technical optimization scheme of the invention, in second area in preparation 3 side adjacent with the process chamber 2
Equipped between sterilizing 32；It is connected between 32 and the process chamber 2 by sliding door between the sterilizing；The culture medium system
Between standby 32 between 14 and the sterilizing between be equipped with double door leafs pass-through box；Cleanup crew can be by the article between sterilizing 32
It is handled between feeding processing；Residue in culture medium preparation room is being sent into after being sent by double door leaf pass-through boxes between sterilizing
Process chamber is handled.
The super of indoor generation negative pressure can be made by being equipped with as a kind of technical optimization scheme of the invention, inside the preparation room 1
Mute blower；The super-silent fan outlet is equipped with air processor；Make to generate negative pressure purpose inside preparation room.
As a kind of technical optimization scheme of the invention, between the flushing 32 between 47 and the sterilizing between be equipped with it is double
Door leaf pass-through box.
As a kind of technical optimization scheme of the invention, the preparation room 1 is equipped with sealing glass with 2 junction of process chamber
Glass door 11；There is dangerous leakage in sliding door one end that the process chamber 2 passes in and out, experimentation in the sealed glass door 11
When, break sealed glass door into pieces, and flee to outside laboratory by the double door of process chamber.
It should be noted that other double doors are equipped with entrance guard device in addition to the double door on process chamber is not provided with gate inhibition.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied；All within the spirits and principles of the present invention, made any to repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (9)
1. a kind of cell prepares laboratory, including preparation room (1), it is characterised in that: the surrounding of the preparation room (1) is successively arranged
Logistics room (5), process chamber (2), stream of people room (4) and monitoring room (6)；It is equipped between the monitoring room (6) and the preparation room (1)
First area in preparation (7)；The second area in preparation (3) are equipped between the stream of people room (4) and the preparation room (1)；The preparation room (1)
The adjacent side of the internal and described process chamber (2) is equipped with the culture between adjacent culturing room (12) and culture medium preparation (14)
Room (12) is adjacent with the logistics room (5), and (14) are adjacent with second area in preparation (3) between the culture medium preparation；The system
It is equipped between sterile room (15) and the 4th buffering (16) for the adjacent side in room (1) inside and first area in preparation (7), institute
It is adjacent with the logistics room (5) and culturing room (12) to state sterile room (15), it is described 4th buffering between (16) with it is described sterile
Operating room (15) and the second area in preparation (3) are adjacent, between the 4th buffering between (16) and culturing room (12) and culture medium preparation
(14) adjacent washroom (13) and disinfection room (17), the washroom (13) and the sterile room (15) phase are equipped between
Neighbour, the disinfection room (17) are adjacent with second area in preparation (3).
2. a kind of cell according to claim 1 prepares laboratory, which is characterized in that the culturing room (12) and the training
Double door leafs pass-through box is equipped between (14) between feeding base preparation；It is equipped between the sterile room (15) and the washroom (13) double
Door leaf pass-through box.
3. a kind of cell according to claim 1 prepares laboratory, which is characterized in that the stream of people room (4) is internal successively
Equipped with (43) and the first gas between (41), changing rooms (42), ultraviolet light sterilization between the first buffering for leading to first area in preparation (7)
Lock chamber (44)；It is also successively arranged inside the stream of people room (4) towards (45), punching between the second buffering of second area in preparation (3)
(47) and the second air lock (48) between washing；It is described second buffering between (45) and it is described first buffer between (41), changing rooms (42) and
(43) are adjacent between ultraviolet light sterilization, it is described second buffering between (45) other side be equipped with dry house (46), between the flushing (47) with
(45) and dry house (46) are adjacent between second buffering, and second air lock (48) and first air lock (44) and second are quasi-
Preparation area (3) is adjacent.
4. a kind of cell according to claim 1 prepares laboratory, which is characterized in that include inside the logistics room (5)
Between material conveying (51) and between material conveying (51) between adjacent cellular identification (52)；(52) are another between the cellular identification
Side is connected with the cell storeroom (53) adjacent with the preparation room (1) and the first area in preparation (7)；Between the material conveying
(51) bottom is equipped with double door；Double door leafs there are two being set side by side between (52) between (51) and the cellular identification between the material conveying
Pass-through box；(52) side is equipped between third buffering (521) between the cellular identification；(521) are equipped between the third buffering
Enter the double door of (521) between third buffering；It is equipped between (52) and the cell storeroom (53) between the cellular identification
Sliding door；Double door leafs pass-through box is equipped between the cell storeroom (53) and the sterile room (15).
5. a kind of cell according to claim 1 prepares laboratory, which is characterized in that the monitoring room (6) and described the
Surely preparation area (7) adjacent side uses glass wall construction.
6. a kind of cell according to claim 3 prepares laboratory, which is characterized in that in second area in preparation (3) with
The adjacent side of the process chamber (2) is equipped between sterilizing (32)；Between the sterilizing (32) and the process chamber (2) it
Between pass through sliding door be connected to；Double door leafs pass-through box is equipped between (14) and the sterilizing between (32) between the culture medium preparation.
7. a kind of cell according to claim 1 prepares laboratory, which is characterized in that be equipped with inside the preparation room (1)
It can make the super-silent blower of indoor generation negative pressure；The super-silent fan outlet is equipped with air processor.
8. a kind of cell according to claim 6 prepares laboratory, which is characterized in that (47) are killed with described between the flushing
Double door leafs pass-through box is equipped between bacterium disinfection room (32).
9. a kind of cell according to claim 1 prepares laboratory, which is characterized in that the preparation room (1) and the place
It manages room (2) junction and is equipped with sealed glass door (11)；Push-and-pull of the sealed glass door (11) close to the process chamber (2) disengaging
Door one end.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711387341.9A CN107965167B (en) | 2017-12-20 | 2017-12-20 | Cell preparation laboratory design scheme |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711387341.9A CN107965167B (en) | 2017-12-20 | 2017-12-20 | Cell preparation laboratory design scheme |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107965167A CN107965167A (en) | 2018-04-27 |
| CN107965167B true CN107965167B (en) | 2019-05-10 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711387341.9A Active CN107965167B (en) | 2017-12-20 | 2017-12-20 | Cell preparation laboratory design scheme |
Country Status (1)
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| CN (1) | CN107965167B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPWO2021125042A1 (en) * | 2019-12-16 | 2021-06-24 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2509287Y (en) * | 2001-12-17 | 2002-09-04 | 钟毓秀 | Assembling standard purifying working room |
| CN101619285B (en) * | 2009-07-15 | 2014-08-27 | 闫铭杰 | Production platform system of human body fluid and tissue cells |
| HU230312B1 (en) * | 2013-11-27 | 2015-12-28 | Honvédelmi Minisztérium Elektronikai, Logisztikai és Vagyonkezelő Zártkörűen Működő Részvénytársaság | Container with a self- supporting, expansionable frame-structure for a lab |
| JP2017055728A (en) * | 2015-09-18 | 2017-03-23 | 憲隆 福永 | Cell culture room and culture facility |
| WO2017156420A1 (en) * | 2016-03-10 | 2017-09-14 | Lonza Ltd | Customizable facility |
| CN105909000B (en) * | 2016-05-31 | 2018-06-05 | 四川川净洁净技术股份有限公司 | Between the sterile gas lock of the stream of people/logistics |
| CN206290019U (en) * | 2016-12-26 | 2017-06-30 | 中南大学 | A kind of new cell culture chamber |
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| CN107965167A (en) | 2018-04-27 |
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Effective date of registration: 20200201 Address after: 100032 Beijing city Xicheng District Xishiku Street No. 31 Building No. 23 hospital Patentee after: Beijing tangyihuikang Biomedical Technology Co., Ltd Address before: 100032 Beijing city Xicheng District Xishiku Street No. 31 Building No. 23 hospital Patentee before: BEIJING ZHEN HUIKANG BIOLOGICAL TECHNOLOGY Co.,Ltd. |
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Effective date of registration: 20220520 Address after: Room 104, building 27, yard 31, Xishiku street, Xicheng District, Beijing 100032 Patentee after: Beijing distance education Education Technology Center Patentee after: Beijing tangyihuikang Biomedical Technology Co., Ltd Address before: Building 23, yard 31, Xishiku street, Xicheng District, Beijing 100032 Patentee before: Beijing tangyihuikang Biomedical Technology Co.,Ltd. |